http://identifiers.org/biomodels.db/MODEL1310110010#_2d3db6f2_4181_4801_b548_c96910c2c4fc
is: SBO:0000252
initial concentration: NaN
name: SC5DL
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: Q6GTM5
constant: false
is encoded by: hsa:6309

metaR r0139
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
is described by: ECO:0000000
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
is: SBO:0000176
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaM idp c
is: SBO:0000247
boundary condition: false
is: CHEBI:58280
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
initial concentration: 1.0
has only substance units: false
name: IDP(3-)
initial amount: NaN
is: HMDB03335

http://identifiers.org/biomodels.db/MODEL1310110010#_906dcb01_5f39_4a6a_9230_6234e1fc2346
has only substance units: false
initial concentration: NaN
is: Q8IUC8
name: GALNT13
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:114805
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_002a1e5e_d225_4a1f_9f15_3f8518ddf50d
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: _100128062_1_m
initial concentration: NaN
is encoded by: hsa:100128062
is: SBO:0000252
has only substance units: false

metaM fuc L c
has only substance units: false
name: L-fucose
type: Species
is: CHEBI:18287
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626

metaM dcmp n
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:57566
name: dCMP(2-)
is: HMDB01202
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

metaR r0960
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true

metaM galside hs g
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247
is: CHEBI:12947
type: Species
initial concentration: 1.0
boundary condition: false

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM chsterol e
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
boundary condition: false
is: CHEBI:16113
initial amount: NaN
name: cholesterol
type: Species
is: SBO:0000247
constant: false
is: HMDB00067
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_1fe71202_481b_4d79_aeb6_2163efdc30be
has only substance units: false
is encoded by: hsa:10195
initial concentration: NaN
boundary condition: true
type: Species
name: ALG3
initial amount: NaN
is: SBO:0000252
constant: false

metaR r0557
reactant: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
reversible: false
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61

metaM lnlccrn m
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
is: HMDB06469
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM bilglcur c
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: SBO:0000247
initial concentration: 1.0
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57767

metaM 3aib D c
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
is: C03265
name: D-3-Amino-isobutanoate
initial concentration: 1.0
boundary condition: false
is: HMDB02299
is: SBO:0000247

metaR r1380
is: SBO:0000176
fast: false
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#

metaM ksi deg14 l
constant: false
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
has only substance units: false
name: keratan sulfate I, degradation product 14
type: Species
is: HMDB00143
boundary condition: false

metaM fadh2 m
is: CHEBI:58307
is: C01352
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: HMDB01197
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: Flavin adenine dinucleotide reduced

http://identifiers.org/biomodels.db/MODEL1310110010#_af70d33e_6206_46d8_b53d_4b4509aed1f6
is: SBO:0000252
initial concentration: NaN
is: O00400
boundary condition: true
name: SLC33A1
constant: false
type: Species
is encoded by: hsa:9197
initial amount: NaN
has only substance units: false

metaR DINt
name: deoxyinosine transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
reactant: MODEL1310110010#
reversible: true
product: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_b3c069ad_1087_42af_a664_9dd09f0b4b3e
is encoded by: hsa:285973
is: SBO:0000252
is: Q674R7
initial amount: NaN
name: ATG9B
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaM Asn X Ser Thr r
boundary condition: false
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
is: HMDB00051
is: C01342
is: CHEBI:28938
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: protein-linked asparagine residue (N-glycosylation site)

metaR P5CR
is: SBO:0000176
name: pyrroline-5-carboxylate reductase
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
reversible: false
product: MODEL1310110010#

metaM ksii core4 pre5 g
is: HMDB00175
has only substance units: false
notes: FORMULA: C69H112N6O48X CHARGE: -1
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
initial concentration: 1.0
constant: false
type: Species
name: keratan sulfate II biosynthesis, precursor 5
initial amount: NaN
is: C00130

metaR BHBtm
type: Reaction
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
product: MODEL1310110010#

metaR r0558
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
modifier: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

metaR UDPACGALtl
is: SBO:0000185
name: udpacgal intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
fast: false
reactant: MODEL1310110010#
product: MODEL1310110010#

metaM HC01407 m
type: Species
is: CHEBI:28276
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: (S)-Hydroxyhexanoyl-CoA
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
initial concentration: 1.0

metaM 5dpmev x
name: (R)-5-Diphosphomevalonate
has only substance units: false
constant: false
boundary condition: false
is: HMDB01090
is: CHEBI:15899
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_5c2f6dff_b356_4c97_8abd_400825fc9ebd
constant: false
has only substance units: false
is encoded by: hsa:AI191472
boundary condition: true
name: _AI191472_1_c
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_4a637c36_0ffa_46e5_bef9_fe28e6b15821
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:728226
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: _728226_1_m

metaM o2s c
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
is: HMDB02168
boundary condition: false
name: superoxide
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:18421
type: Species

metaR r2379
fast: false
is: SBO:0000185
product: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
reactant: MODEL1310110010#
reversible: true

metaM ksi g
has only substance units: false
initial amount: NaN
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB01014
is: SBO:0000247
name: keratan sulfate I
type: Species
constant: false
is: CHEBI:57255
boundary condition: false
initial concentration: 1.0

metaR GASNASEly
modifier: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.26
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110010#
name: glycosylasparaginase, lysosomal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_86289c0c_9a80_4022_b26c_6153b5802cd2
is encoded by: hsa:50808
has only substance units: false
initial amount: NaN
is: E7ET30
type: Species
initial concentration: NaN
is: SBO:0000252
name: AK3
boundary condition: true
constant: false

metaM na1 c
initial concentration: 1.0
is: CHEBI:4541
constant: false
is: HMDB00588
type: Species
is: C01330
has only substance units: false
boundary condition: false
name: Sodium
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_083121e0_8c9d_431c_8f8c_531ec7e8cf17
constant: false
is: O43674
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: NDUFB5
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4711

metaR SR5ARr
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
is described by: ECO:0000134
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
reactant: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.5
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_35bd66d0_1211_416f_9bbc_0375310c1bc1
is encoded by: hsa:5831
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is: A6NFM2
name: PYCR1
has only substance units: false
initial amount: NaN
type: Species

metaM sgalside hs c
is: SBO:0000247
name: sulfatide galactocerebroside
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:16523
initial amount: NaN
is: HMDB03406

metaR CYTDt
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110010#
name: cytidine facilated transport in cytosol
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reversible: true
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR ATP1ter
product: MODEL1310110010#
type: Reaction
reversible: true
reactant: MODEL1310110010#
name: ADP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_4ae5948d_a65e_41b1_ae18_fc8605625f2a
constant: false
is: P22680
initial concentration: NaN
boundary condition: true
has only substance units: false
name: CYP7A1
is encoded by: hsa:1581
type: Species
is: SBO:0000252
initial amount: NaN

metaM idp e
constant: false
type: Species
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
name: IDP(3-)
has only substance units: false
initial amount: NaN
is: HMDB03335
is: SBO:0000247
is: CHEBI:58280

metaR r0559
type: Reaction
modifier: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
reactant: MODEL1310110010#
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1

metaM pmtcrn r
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
boundary condition: false
constant: false
type: Species
is: CHEBI:17490
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_59f37527_3919_4fea_8c7d_204d3b5e02dd
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
name: GLO1
is: Q04760
is encoded by: hsa:2739

metaM ksi e
has only substance units: false
name: keratan sulfate I
is: HMDB00211
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17268
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
constant: false

metaR DNDPt20m
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: dTDP transport via ATP antiport
is: SBO:0000185
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
kinetic law: MODEL1310110010#
is described by: ECO:0000269
fast: false
type: Reaction

metaM 3aib D e
initial amount: NaN
is: SBO:0000247
name: D-3-Amino-isobutanoate
is: C03265
boundary condition: false
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: HMDB02299
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_2f9462c5_c0c1_4e57_972a_3f48ec635745
is: B1AM93
initial amount: NaN
name: NDUFA8
is encoded by: hsa:4702
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaM xol7ah c
boundary condition: false
has only substance units: false
is: HMDB06892
type: Species
constant: false
initial concentration: 1.0
name: 7alpha-hydroxy-5beta-cholestan-3-one
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: CHEBI:2290
initial amount: NaN

metaM bilglcur e
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
initial concentration: 1.0
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
has only substance units: false
is: CHEBI:57767
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_a814436b_712e_41c4_9e0e_3efa1ee65eea
constant: false
initial amount: NaN
name: SPR
is encoded by: hsa:6697
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P35270

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR MTHFDm
reactant: MODEL1310110010#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/6.3.4.3
type: Reaction
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
reversible: true
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176

metaM ksii core4 deg3 l
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
name: keratan sulfate II (core 4-linked), degradation product 3

http://identifiers.org/biomodels.db/MODEL1310110010#_f98f139f_e52e_4f5c_8a79_2e6d412b6f2b
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:3636
is: SBO:0000252
name: INPPL1
boundary condition: true
type: Species
is: O15357
initial concentration: NaN

metaM mev R x
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: CHEBI:36464
has only substance units: false
initial amount: NaN
name: (R)-mevalonate
initial concentration: 1.0
is: HMDB00227

metaR BHBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: (R)-3-Hydroxybutanoate transport via H+ symport
reversible: true

metaM rib D c
is: HMDB00283
name: D-ribose
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:16988
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119

metaR PSERT
name: phosphoserine transaminase
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.6.1.52
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR SAMHISTA
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.1.8
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
fast: false
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_3bf8e9aa_e88f_4fc1_aa5d_24a92e3635d3
is encoded by: hsa:8876
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8875
is encoded by: hsa:55350
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000297
has part: O95497
name: VNN3:VNN2:VNN1
has part: A8K7W0
constant: false

metaR APOC LYS BTNPm
product: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: false
reactant: MODEL1310110010#
name: proteolysis of apoC-Lys-btn, mitochondrial

metaR FOLt2le
name: folate transport via anion exchange
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110010#
is described by: ECO:0000134
reversible: true
type: Reaction
fast: false
is: SBO:0000185

metaR LALDO
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
type: Reaction
is: SBO:0000176
modifier: MODEL1310110010#
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
is described by: ECO:0000000
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
fast: false

metaR S23T4g
type: Reaction
kinetic law: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
reactant: MODEL1310110010#
name: beta-galactoside alpha-2,3-sialyltransferase
is version of: http://identifiers.org/ec-code/2.4.99.4
is: SBO:0000176
modifier: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_da454230_0d2d_434c_b311_d4defa04c761
is: E9KL44
type: Species
initial concentration: NaN
constant: false
name: HADHA
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3030
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_4957b3f2_d0f2_4122_a351_024af0bae00a
initial concentration: NaN
is: Q9BZX2
is encoded by: hsa:7371
initial amount: NaN
is: SBO:0000252
name: UCK2
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR BAMPPALDOX
is: SBO:0000176
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
reactant: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110010#
reversible: false
fast: false
is described by: ECO:0000212
modifier: MODEL1310110010#

metaR r1381
product: MODEL1310110010#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reversible: true
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000

metaR LDH D
is described by: ECO:0000304
modifier: MODEL1310110010#
name: D-lactate dehydrogenase
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.2.4
reversible: true

metaR PMEVKx
is described by: ECO:0000134
modifier: MODEL1310110010#
name: phosphomevalonate kinase
type: Reaction
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.2

metaR ACGAMK
name: N-acetylglucosamine kinase
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
product: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.1.59
reversible: false

metaM 2hb c
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: CHEBI:1148
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00008
initial concentration: 1.0
name: 2-Hydroxybutyrate

metaM so4 m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:16189
name: sulfate
has only substance units: false
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448

metaR FAOXC246226x
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:6 -> c22:6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6

http://identifiers.org/biomodels.db/MODEL1310110010#_8f4e4900_1e91_49be_b45c_280679149368
has part: P00325
is encoded by: hsa:125
type: Species
name: ADH1A:ADH1B
has only substance units: false
initial concentration: NaN
boundary condition: true
has part: P07327
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:124
constant: false

metaR VLCSp
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110010#
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_646e1421_e7e5_4cdd_b199_2135983d7845
has only substance units: false
is: Q9BRC7
initial amount: NaN
name: PLCD4
is: SBO:0000252
constant: false
is encoded by: hsa:84812
boundary condition: true
type: Species
initial concentration: NaN

metaM pacald c
is: SBO:0000247
type: Species
name: phenylacetaldehyde
has only substance units: false
boundary condition: false
is: HMDB06236
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
initial amount: NaN
constant: false
is: CHEBI:16424
initial concentration: 1.0

metaR SADT
fast: false
reactant: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
name: sulfate adenylyltransferase
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.1.25

metaR r1384
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110010#
name: Guanosine aminohydrolase EC:3.5.4.15
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#

metaM accoa n
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: acetyl-CoA(4-)
constant: false
is: HMDB01206
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:57288

metaM HC02179 e
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:34306
constant: false
type: Species
boundary condition: false
has only substance units: false
name: 20-hydroxy-arachidonate

http://identifiers.org/biomodels.db/MODEL1310110010#_d716d008_2c49_48ca_9c8b_52ceb939fff9
is encoded by: hsa:60490
is: Q96CD2
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: PPCDC
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_706d0e64_b180_4634_9b1c_a293ec7d1f09
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:55568
constant: false
boundary condition: true
name: GALNT10
initial concentration: NaN
is: SBO:0000252

metaM HC01376 m
type: Species
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
name: S-(2-Methylbutanoyl)-dihydrolipoamide
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:28692

metaM CE4794 m
has only substance units: false
initial concentration: 1.0
is: CHEBI:12947
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
boundary condition: false
name: cis-6-dodecenoyl-CoA
initial amount: NaN
constant: false
type: Species

metaR AG13T7g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_7863b475_c322_424f_9652_5f35673c5684
name: NDUFS6
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:4726
initial concentration: NaN
is: Q6IBC4
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_4d5e465c_881f_4e31_805c_b0fbac5d6212
is: SBO:0000252
initial concentration: NaN
is: A8MU28
type: Species
has only substance units: false
is encoded by: hsa:8883
constant: false
name: NAE1
initial amount: NaN
boundary condition: true

metaM urate c
type: Species
initial concentration: 1.0
initial amount: NaN
name: Urate
is: HMDB00289
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
has only substance units: false
is: CHEBI:17775
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_dc82d25d_aaa4_4e00_9b6f_dcb2ee4d3ae8
is: SBO:0000252
constant: false
initial amount: NaN
name: SLC6A10P
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:386757
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_58ebf65a_a441_45e6_8b77_83f5c320a7da
constant: false
is encoded by: hsa:AI934540
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _AI934540_1_c

metaM CE5119 m
is: CHEBI:12947
name: trans-3-cis-8-tetradecadienoyl-CoA
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
has only substance units: false
is: SBO:0000247

metaM so4 l
name: sulfate
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB01448
is: SBO:0000247
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
initial amount: NaN

metaM 34hpp c
is: CHEBI:36242
is: HMDB00707
boundary condition: false
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
constant: false
has only substance units: false
initial amount: NaN

metaM dgchol e
is: HMDB00637
is: CHEBI:36252
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
name: glycochenodeoxycholate
constant: false
has only substance units: false
is: SBO:0000247

metaM accoa m
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
type: Species
is: CHEBI:57288
constant: false
is: HMDB01206
is: SBO:0000247
is: C00024
name: Acetyl-CoA
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_89dea9a0_cc8b_483e_86ae_eb3bba5f0b8c
is: E9KL48
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:2746
name: GLUD1

metaR PItn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
reversible: true
type: Reaction
name: phosphate transport, nuclear
fast: false
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_f4cdfe8e_c084_490f_b9cf_fdd0667f0c00
is encoded by: hsa:2184
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: P16930
type: Species
name: FAH

http://identifiers.org/biomodels.db/MODEL1310110010#_30f50f97_d884_4413_bade_e7f3513f3d0a
initial concentration: NaN
is: SBO:0000252
is: G3V0F6
name: DGKZ
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:8525

http://identifiers.org/biomodels.db/MODEL1310110010#_ebb222eb_3d11_4b3c_8912_6ad5e516025b
initial amount: NaN
is: E7EUT4
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:2597
type: Species
boundary condition: true
initial concentration: NaN
name: GAPDH

http://identifiers.org/biomodels.db/MODEL1310110010#_794fa806_f33c_4b25_a57a_a6b0a3c606fc
is encoded by: hsa:79646
initial concentration: NaN
boundary condition: true
is: Q9H999
is: SBO:0000252
name: PANK3
type: Species
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_517cd0a6_3638_47dd_8e28_b71dd3680a12
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: HAO2
has only substance units: false
is encoded by: hsa:51179
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_8bc9e184_80d4_48db_89db_2a9a45feab5c
name: _206_1_c
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:206
initial amount: NaN

metaM HC01162 c
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:58376
initial amount: NaN
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
type: Species
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: SBO:0000247
has only substance units: false

metaR r0962
product: MODEL1310110010#
kinetic law: MODEL1310110010#
name: Facilitated diffusion
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#

metaM CE2839 e
has only substance units: false
boundary condition: false
name: maltodecaose
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
is: C01936
type: Species
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839

http://identifiers.org/biomodels.db/MODEL1310110010#_62635f83_a79b_4c47_919e_c18d5254f85d
name: ABCB4
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5244

metaM chsterol c
has only substance units: false
type: Species
constant: false
is: CHEBI:16113
is: HMDB00067
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
name: cholesterol
initial concentration: 1.0
is: SBO:0000247

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_10674572_2177_4f3a_b015_597f7f537254
boundary condition: true
constant: false
initial amount: NaN
is: P15104
name: GLUL
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:2752
initial concentration: NaN

metaR RE1573M
is: SBO:0000176
name: RE1573
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_b856559d_c943_43bc_b6cf_5fc72e44ec85
boundary condition: true
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: Q8IXK2
is: SBO:0000252
is encoded by: hsa:79695
name: GALNT12
initial amount: NaN

metaM hcys L c
type: Species
is: HMDB00742
initial concentration: 1.0
initial amount: NaN
name: L-homocysteine
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
is: CHEBI:17588
has only substance units: false

metaM 5HPET c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB01193
is: CHEBI:57450
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
name: 5(S)-HPETE(1-)

metaR LEUt5m
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: leucine mitochondrial transport
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
fast: false
is: SBO:0000185

metaM urate e
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00289
is: SBO:0000247
name: Urate
boundary condition: false
is: C00366
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
constant: false
is: CHEBI:17775

http://identifiers.org/biomodels.db/MODEL1310110010#_1f98c13c_29f7_4f57_b5e3_1a354470be01
initial amount: NaN
is encoded by: hsa:4722
initial concentration: NaN
constant: false
is: SBO:0000252
is: O75489
name: NDUFS3
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_c874a64b_a3ba_4e54_996c_a88631612209
is encoded by: hsa:8876
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: VNN1
is: O95497
is: SBO:0000252
initial concentration: NaN

metaM Asn X Ser Thr l
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00051
is: C01342
is: CHEBI:28938
constant: false
name: protein-linked asparagine residue (N-glycosylation site)
type: Species
has only substance units: false
notes: FORMULA: XH CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110010#_4fc35ce3_5128_48eb_b910_9eef96a9db22
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:D29675
type: Species
name: _D29675_1_e
initial amount: NaN
constant: false

metaR TMNDNCCOAtx
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
product: MODEL1310110010#
is: SBO:0000185
fast: false
reversible: true
type: Reaction

metaM galside hs l
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:12947

metaR 3MOPt2im
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM

metaM strdnccoa x
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial amount: NaN
is: HMDB06519
is: http://identifiers.org/pubchem.compound/47205473
type: Species
name: stearidonyl coenzyme A
is: C16163
is: SBO:0000247
constant: false
boundary condition: false

metaM 34hpp e
name: 3-(4-hydroxyphenyl)pyruvate
initial concentration: 1.0
is: CHEBI:36242
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
boundary condition: false
is: HMDB00707

metaM dgchol c
is: SBO:0000247
is: HMDB00637
initial concentration: 1.0
is: CHEBI:36252
boundary condition: false
initial amount: NaN
name: glycochenodeoxycholate
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
has only substance units: false
type: Species
constant: false

metaM na1 e
type: Species
constant: false
is: HMDB00588
is: C01330
initial concentration: 1.0
has only substance units: false
name: Sodium
is: SBO:0000247
initial amount: NaN
is: CHEBI:4541
boundary condition: false
notes: FORMULA: Na CHARGE: 1

http://identifiers.org/biomodels.db/MODEL1310110010#_0869506e_45bb_4907_a63e_5e7d714a8d57
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: CHAT
is: P28329
is: SBO:0000252
is encoded by: hsa:1103
initial amount: NaN

metaR MCLOR
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
modifier: MODEL1310110010#
reversible: true
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
reactant: MODEL1310110010#
name: 3-Mercaptolactate:NAD+ oxidoreductase

metaR r0494
reversible: true
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110010#

metaR N4Tg
is described by: ECO:0000000
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000176

metaR PPNCL3
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: phosphopantothenate-cysteine ligase
product: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.5
is described by: ECO:0000269
reversible: false
is: SBO:0000176

metaR MEVK1x
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
type: Reaction
modifier: MODEL1310110010#
name: mevalonate kinase (atp)
is: SBO:0000176
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
is version of: http://identifiers.org/ec-code/2.7.1.36
is described by: ECO:0000134
reversible: false

metaM CE2434 m
boundary condition: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
is: C01936
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
initial concentration: 1.0
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial amount: NaN
constant: false

metaM fuc L l
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:18287
initial concentration: 1.0
type: Species
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
name: L-fucose
initial amount: NaN
constant: false
is: HMDB00174

metaM ksi deg8 l
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
boundary condition: false
is: SBO:0000247
is: HMDB00143
initial amount: NaN
constant: false
has only substance units: false
name: keratan sulfate I, degradation product 8
initial concentration: 1.0
type: Species
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110010#_1a853d1b_dc9a_45c6_a692_220a5a54aa89
type: Species
is encoded by: hsa:4728
boundary condition: true
is: O00217
initial concentration: NaN
is: SBO:0000252
name: NDUFS8
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_2363a7b1_86dc_4fda_98a5_8f4227ce907f
name: PKLR
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:5313
initial amount: NaN
initial concentration: NaN
is: P30613

metaR DM fol
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_be0ccc2b_8df6_4ef3_9436_d86698227538
is encoded by: hsa:57282
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: B7Z1R0
boundary condition: true
constant: false
has only substance units: false
name: SLC4A10

metaM Rtotal3 c
is: SBO:0000247
notes: FORMULA: CO2FULLR3 CHARGE: -1
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:16189
is: HMDB01448
has only substance units: false
type: Species
constant: false
name: R total 3 position

metaM methf c
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: C00445
is: HMDB01354
type: Species
is: SBO:0000247
is: CHEBI:57455
name: 5,10-Methenyltetrahydrofolate
initial amount: NaN
initial concentration: 1.0

metaR OCTAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#
type: Reaction
name: Octanoate transport via diffusion

metaR PPAt
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
product: MODEL1310110010#
name: Propionate transport, diffusion
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_a80876c5_8b27_4e18_a340_d5b1ac068cb5
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:377841
is: SBO:0000252
name: ENTPD8
is: Q5MY95
initial concentration: NaN
has only substance units: false
type: Species

metaR r1633
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#

metaR r1655
kinetic law: MODEL1310110010#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false

metaR SUCCtp
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
name: succinate transporter, peroxisome
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_44464308_966f_454e_b06b_65e4d86d3daa
is encoded by: hsa:122481
is: Q96M32
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: AK7
initial amount: NaN
initial concentration: NaN

metaR PA HSter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: phosphatidate scramblase
reversible: true
type: Reaction
reactant: MODEL1310110010#

metaR SIAT9g
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.9
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
modifier: MODEL1310110010#
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110010#

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_63ddd946_1a5c_4dc8_8925_cc490db48a68
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:4704
is: Q16795
constant: false
name: NDUFA9
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM chsterol m
is: HMDB00067
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:16113
type: Species
constant: false

metaR DCYTDn
product: MODEL1310110010#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.5
fast: false
modifier: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
type: Reaction
kinetic law: MODEL1310110010#
name: deoxycytidine deaminase, nuclear
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_cf2cb796_f63c_4c63_9943_276a640cbda7
is encoded by: hsa:AI926493
initial amount: NaN
initial concentration: NaN
type: Species
name: _AI926493_1_c
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaM o2 x
initial amount: NaN
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
name: O2
constant: false
is: HMDB01377
initial concentration: 1.0
is: C00007
is: SBO:0000247
type: Species
has only substance units: false

metaR RE0383C
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
name: RE0383
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is: SBO:0000176
reactant: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000

metaM CE0785 m
boundary condition: false
name: cis,cis-myristo-5,8-dienoyl-CoA
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C01936
is: http://identifiers.org/pubchem.compound/5041
type: Species
constant: false

metaR r1632
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#

metaR RE2675C
notes: GENE_ASSOCIATION: (8560.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10722759,PMID:10880336,PMID:11937514,PMID:8449895 NOTES:
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
is: SBO:0000176
name: RE2675
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_a7f298cb_827f_4abe_98ed_de951e5f5d75
is encoded by: hsa:441024
name: MTHFD2L
constant: false
initial amount: NaN
is: Q9H903
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR LTD4DP
product: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reversible: true
fast: false
name: Leukotriene D4 dipeptidase
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#

metaM g1m8mpdol U r
constant: false
type: Species
boundary condition: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
initial concentration: 1.0
is: CHEBI:59093
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110010#_a5fefb53_697e_47be_afc5_46d7d8f5cca9
name: PRDX1
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5052
type: Species
is: SBO:0000252
constant: false

metaM prostgf2 c
is: SBO:0000247
name: prostaglandin F2alpha(1-)
is: CHEBI:57404
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01139
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639

metaR r1654
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110010#_353d09b4_1715_4ef5_a7bd_c8b79dd58a0e
name: FASN
initial concentration: NaN
is: P49327
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:2194
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_56accefa_1c7d_4678_8936_1b39a5fe231c
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: _AA419122_1_c
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA419122

metaM dcacoa c
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
constant: false
has only substance units: false
is: C05274
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB06404
is: SBO:0000247
is: CHEBI:61430

metaM 3aib D m
has only substance units: false
initial amount: NaN
is: C03265
initial concentration: 1.0
boundary condition: false
type: Species
name: D-3-Amino-isobutanoate
is: HMDB02299
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_0cc24b22_72fb_4141_8c7d_ca95680e5538
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:30
name: ACAA1
is: Q96CA6
has only substance units: false
constant: false

metaR ILETAm
is: SBO:0000176
name: isoleucine transaminase, mitochondrial
is described by: ECO:0000269
product: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110010#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42

http://identifiers.org/biomodels.db/MODEL1310110010#_38d87caa_3a41_40d5_bb10_40e0580ffdc2
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P31350
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6241
name: RRM2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_37cb1318_2f47_4dc1_83ad_88ea8841a7ff
is: O76062
name: TM7SF2
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:7108
constant: false
is: SBO:0000252
initial concentration: NaN

metaM HC02179 c
is: CHEBI:34306
constant: false
type: Species
has only substance units: false
name: 20-hydroxy-arachidonate
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

http://identifiers.org/biomodels.db/MODEL1310110010#_c3b370b9_af1b_490f_8616_96e04ccc54e4
is encoded by: hsa:NM 013421
constant: false
has only substance units: false
name: _NM_013421_1_e
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM mi1345p c
is: CHEBI:57895
initial amount: NaN
type: Species
constant: false
is: HMDB01059
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
has only substance units: false
is: SBO:0000247

metaM Rtotal3 e
is: HMDB00244
name: R total 3 position
notes: FORMULA: CO2FULLR3 CHARGE: -1
boundary condition: false
initial concentration: 1.0
is: C00255
constant: false
type: Species
has only substance units: false
is: CHEBI:3554
is: SBO:0000247
initial amount: NaN

metaM 10fthf5glu e
type: Species
is: CHEBI:57454
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00972
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](5)
constant: false
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial concentration: 1.0

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR r1631
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#

metaR ABTti
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
product: MODEL1310110010#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110010#
name: L-arabinitol transport via passive diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110010#

metaR DM 13 cis retn n
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 13-cis-retinoate demand
type: Reaction

metaM xu5p D c
is: CHEBI:57737
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: HMDB00868
initial amount: NaN
has only substance units: false
boundary condition: false
name: D-xylulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209

metaR GULN3D
name: L-gulonate 3-dehydrogenase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
type: Reaction
product: MODEL1310110010#
fast: false
reversible: true

metaR GGH 6THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
is described by: ECO:0000000
reversible: false
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
name: Gamma-glutamyl hydrolase (6THF), extracellular
type: Reaction
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_bdbe2bae_01dc_4284_843a_506a0fcdde5e
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:U37519
is: SBO:0000252
initial concentration: NaN
name: _U37519_1_m
boundary condition: true

metaR r1657
modifier: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_fc82e968_9109_4eeb_9180_e3180395a88d
name: PMM2
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:5373
is: O15305
constant: false
is: SBO:0000252
initial concentration: NaN

metaR RE1532M
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
product: MODEL1310110010#
name: RE1532
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110010#
reversible: true

metaR ADEt
modifier: MODEL1310110010#
product: MODEL1310110010#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000185
reversible: true
name: adenine reversible transport, cytosol

http://identifiers.org/biomodels.db/MODEL1310110010#_d8de10d9_baed_4218_b2d1_4c83eba1fdf5
is encoded by: hsa:6567
is: SBO:0000252
name: SLC16A2
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: P36021

metaM dcmp c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: dCMP
is: CHEBI:57566
has only substance units: false
is: HMDB01202
constant: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: C00239
type: Species
initial amount: NaN

metaR r2509
reversible: true
kinetic law: MODEL1310110010#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110010#
name: Utilized transport
product: MODEL1310110010#

metaR r0130
modifier: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
product: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4

http://identifiers.org/biomodels.db/MODEL1310110010#_f801b3d6_da42_4c67_b752_1c074f6a55db
name: FUT8
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:2530
initial concentration: NaN
is: Q546E0

metaM arachdcoa m
initial concentration: 1.0
boundary condition: false
is: CHEBI:57368
initial amount: NaN
name: arachidonoyl-CoA(4-)
is: HMDB06523
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species
constant: false
is: SBO:0000247

metaM accoa x
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: C00024
is: CHEBI:57288
name: Acetyl-CoA
boundary condition: false
is: HMDB01206
initial concentration: 1.0

metaR CLHCO3tex2
name: chloride transport via bicarbonate countertransport (2:1)
kinetic law: MODEL1310110010#
reversible: false
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
type: Reaction

metaR r1630
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
reversible: true

metaR NACHEXA19ly
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaR MALSO4tm
name: Malate:sulfate antiport, mitochondrial
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
modifier: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaM gullac c
has only substance units: false
boundary condition: false
is: CHEBI:17587
name: L-gulono-1,4-lactone
is: HMDB03466
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_3b715291_a720_4493_b00e_3ac797d1a941
is encoded by: hsa:58510
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PRODH2
is: Q9UF12
is: SBO:0000252

metaM udpacgal g
is: HMDB00304
is: CHEBI:57847
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
is: SBO:0000247

metaR r1656
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#

metaR r2508
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
name: Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_68bc46c1_3636_46a4_8a5a_9ea56a6df810
type: Species
has only substance units: false
is: Q8TB61
constant: false
boundary condition: true
name: SLC35B2
initial amount: NaN
is encoded by: hsa:347734
initial concentration: NaN
is: SBO:0000252

metaR GULNter
reactant: MODEL1310110010#
fast: false
name: L-gulonate endoplasmic reticular export
reversible: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110010#_63d11d14_8238_475e_a292_068c9279f9bc
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: NOS3
constant: false
is encoded by: hsa:4846
is: SBO:0000252
is: A0S0A7
type: Species
has only substance units: false

metaR r1651
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
type: Reaction
reversible: true

metaM ksi l
is: SBO:0000247
name: keratan sulfate I
initial amount: NaN
is: C00445
is: HMDB01354
is: CHEBI:57455
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM galside hs c
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
name: D-galactosyl-N-acylsphingosine
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:12947
constant: false

metaR AG13T12g
product: MODEL1310110010#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110010#
is: SBO:0000176
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM 6dhf e
type: Species
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
constant: false
is: HMDB06563
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: hexaglutamyl folate (DHF)
has only substance units: false

metaR RE1527M
reactant: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
modifier: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: RE1527

metaM HC01223 m
initial amount: NaN
type: Species
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:57340
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047

metaM 4fumacac c
type: Species
name: 4-fumarylacetoacetate(2-)
boundary condition: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01268
has only substance units: false
is: CHEBI:18034
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_26916bd3_e7c4_495b_8ab6_858c23c793d6
is: SBO:0000252
is: P11086
constant: false
initial amount: NaN
type: Species
name: PNMT
boundary condition: true
has only substance units: false
is encoded by: hsa:5409
initial concentration: NaN

metaM met L c
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00696
is: CHEBI:16643
name: L-methionine
has only substance units: false
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_9d3e64fa_082f_433f_aba5_924ae86d9774
is: P06132
type: Species
has only substance units: false
name: UROD
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:7389

metaR LDH L
type: Reaction
name: L-lactate dehydrogenase
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
product: MODEL1310110010#
is: SBO:0000176

metaR RE2660C
kinetic law: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is: SBO:0000176
reactant: MODEL1310110010#
fast: false
name: RE2660
reversible: true
product: MODEL1310110010#

metaM CE2424 m
type: Species
boundary condition: false
constant: false
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: HMDB11123
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28387
has only substance units: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA

metaR TDCHOLAtx
is: SBO:0000185
product: MODEL1310110010#
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport

metaR RE1691M
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
reactant: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.1.1
fast: false
product: MODEL1310110010#
name: RE1691

metaM pmtcrn x
is: SBO:0000247
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
type: Species
name: L-palmitoylcarnitine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_72be672f_9632_421d_8a37_e4b834801947
is: A6H8L5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:3990
name: LIPC
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_cfa5aa48_3ad5_4ad3_b9d7_cd4a122f444f
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1738
is: SBO:0000252
name: DLD
is: P09622
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_13d60675_3c66_4bb8_8d8e_2360df66399e
is: P12074
constant: false
initial concentration: NaN
initial amount: NaN
name: COX6A1
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:1337
is: SBO:0000252

metaR DESAT22 2p
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110010#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR r2507
kinetic law: MODEL1310110010#
reversible: true
fast: false
is: SBO:0000185
name: Utilized transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110010#
reactant: MODEL1310110010#

metaR THRGLYexR
is described by: ECO:0000304
type: Reaction
reversible: true
name: L-threonine/glycine reversible exchange
modifier: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#

metaM bhb e
initial concentration: 1.0
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false
name: (R)-3-hydroxybutyrate

metaR S6T3g
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.8.2.17
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.21
kinetic law: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is: SBO:0000176
fast: false

metaM apoC Lys btn c
is: HMDB00182
is: SBO:0000247
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial concentration: 1.0
is: CHEBI:32551
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110010#_fcab2597_8f74_4103_be7e_ffa8775a32e8
is encoded by: hsa:4708
initial concentration: NaN
boundary condition: true
type: Species
name: NDUFB2
constant: false
is: H7C5B8
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR GLACter
reversible: true
kinetic law: MODEL1310110010#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum

metaR r1650
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
is described by: ECO:0000000
modifier: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#

metaM HC02208 e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:27696
constant: false
has only substance units: false
name: prostaglandin-d1
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
type: Species

metaM guln c
type: Species
is: SBO:0000247
is: HMDB03290
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: CHEBI:13115
constant: false
name: L-gulonate
boundary condition: false
initial concentration: 1.0

metaR RE3566C
is: SBO:0000176
type: Reaction
reactant: MODEL1310110010#
name: RE3566
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_381179b4_c832_47bf_a367_310dec4aad32
is encoded by: hsa:251
is: SBO:0000252
initial amount: NaN
name: ALPPL2
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: P10696

http://identifiers.org/biomodels.db/MODEL1310110010#_9acc1983_e7a8_4a10_ac4f_50e5ff295919
initial concentration: NaN
is: SBO:0000252
is: P49914
name: MTHFS
has only substance units: false
type: Species
is encoded by: hsa:10588
boundary condition: true
constant: false
initial amount: NaN

metaR BDMT U
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.142
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110010#
type: Reaction

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM sgalside hs g
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB00061
constant: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
name: sulfatide galactocerebroside
is: SBO:0000247
is: CHEBI:58343

metaM HC01412 m
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247
name: trans-tetradec-2-enoyl-CoA(4-)
is: CHEBI:61405
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_b72cb982_7649_4311_8245_c0fca37dcb1c
is: Q96BD0
type: Species
is: SBO:0000252
constant: false
name: SLCO4A1
is encoded by: hsa:28231
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR PPAn
name: inorganic diphosphatase, nuclear
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110010#
reversible: false

metaM chsterol l
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
is: HMDB00067
name: cholesterol
constant: false
boundary condition: false

metaR r1018
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Transport reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: true
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#

metaR r2506
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110010#

metaM mi1p D c
initial concentration: 1.0
boundary condition: false
is: CHEBI:58433
name: 1D-myo-inositol 1-phosphate(2-)
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: HMDB02985
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM galside hs e
type: Species
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR r1653
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110010#
reversible: true
is: SBO:0000185
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM met L e
initial amount: NaN
is: HMDB00696
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: SBO:0000247
is: CHEBI:16643
constant: false
name: L-methionine
has only substance units: false
type: Species

metaR FAOXC183806x
product: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110010#_a3274868_1e74_4250_959e_31c8da2b9650
has only substance units: false
is encoded by: hsa:65263
initial amount: NaN
initial concentration: NaN
is: Q53H96
constant: false
is: SBO:0000252
name: PYCRL
boundary condition: true
type: Species

metaR NCKt
reversible: true
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
name: Na+/Ca2+-K+ exchange
is described by: ECO:0000269
fast: false
is: SBO:0000185

metaM sphings c
is: HMDB00252
has only substance units: false
is: CHEBI:57756
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial concentration: 1.0
name: sphingosine(1+)
type: Species
is: SBO:0000247
constant: false

metaR NACHEX21ly
is: SBO:0000176
fast: false
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR r0074
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
product: MODEL1310110010#
is described by: ECO:0000000
fast: false

metaR AACTtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110010#
name: Aminoacetone transport (mitochondrial)
is: SBO:0000185
reactant: MODEL1310110010#
reversible: false
product: MODEL1310110010#

metaM 10fthf7glu e
constant: false
is: CHEBI:57454
has only substance units: false
is: HMDB00972
is: SBO:0000247
notes: FORMULA: C50H57N13O25 CHARGE: -8
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](7)

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR ACOAO7p
is: SBO:0000176
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110010#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000269
kinetic law: MODEL1310110010#

metaR PPAm
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000269
type: Reaction
reversible: false
reactant: MODEL1310110010#
name: inorganic diphosphatase
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176

metaM bhb c
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: HMDB00011
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
is: CHEBI:10983
initial amount: NaN

metaR r1019
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110010#

metaR PItx
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
fast: false
name: Phosphate transporter, peroxisome
product: MODEL1310110010#

metaM arachd r
name: arachidonate
is: HMDB01043
is: CHEBI:32395
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species

metaM udpacgal l
is: HMDB00304
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: UDP-N-acetyl-D-galactosamine(2-)
is: CHEBI:57847
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203

metaM HC02208 c
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:27696
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
constant: false

metaM o2s e
is: HMDB02168
is: CHEBI:18421
constant: false
type: Species
name: superoxide
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

metaR FAOXC226205x
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110010#
name: Beta oxidation of long chain fatty acid
reversible: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false

metaR r1652
is: SBO:0000185
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110010#
reversible: true
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM prostgf2 e
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57404
initial amount: NaN
name: prostaglandin F2alpha(1-)
constant: false
boundary condition: false
is: HMDB01139
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639

metaR GLYtp
name: glycine passive transport to peroxisome
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_462b3160_943a_4a74_8d0f_dbef6866bb0c
is encoded by: hsa:222
initial amount: NaN
is: P48448
constant: false
name: ALDH3B2
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_b74ff97a_9c70_4d49_a7d3_4c44e04fe41b
initial amount: NaN
is encoded by: hsa:1962
has part: Q9NY65
initial concentration: NaN
is: SBO:0000297
boundary condition: true
name: EHHADH:ACAA1:ACOX1
has only substance units: false
type: Species
constant: false

metaR HSD3A1r
type: Reaction
is: SBO:0000176
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
modifier: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_bc5a5509_8183_4a14_b6b3_2d44d4125f96
name: GPX4
type: Species
boundary condition: true
is: P36969
is encoded by: hsa:2879
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR SCP21x
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110010#
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.176
name: Sterol carrier protein 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ

http://identifiers.org/biomodels.db/MODEL1310110010#_460c1f41_8436_42c0_b6e9_63b8c742b555
boundary condition: true
name: PPT1
initial amount: NaN
is encoded by: hsa:5538
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is: Q6FGQ4

metaR OBDHc
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
is described by: ECO:0000000
fast: false
reactant: MODEL1310110010#
reversible: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
is: SBO:0000176
name: 2-Oxobutanoate dehydrogenase, cytosolic

metaM cit e
name: citrate(3-)
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947
has only substance units: false
initial amount: NaN
is: HMDB00094
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_bcc18ea3_e89f_449e_a9a1_ac9cd5238bf5
is: O60760
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: HPGDS
is encoded by: hsa:27306
has only substance units: false
initial amount: NaN
type: Species

metaM acngalgbside hs g
is: CHEBI:16523
boundary condition: false
is: HMDB03406
constant: false
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
has only substance units: false
name: sialyl galactosylgloboside
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

metaM arachcoa x
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
boundary condition: false
is: CHEBI:15527
name: arachidyl coenzyme A
is: SBO:0000247
constant: false
type: Species
is: HMDB04258
has only substance units: false

metaM h n
is: CHEBI:24636
has only substance units: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
constant: false
type: Species
name: proton
initial concentration: 1.0
initial amount: NaN

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR 3HBCOAHLm
reactant: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
type: Reaction
kinetic law: MODEL1310110010#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_c057bf96_2446_47f6_a41e_593698466396
initial concentration: NaN
is encoded by: hsa:29968
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: PSAT1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_66ec46fd_d6b6_4ee6_84ea_1cf12724303f
initial concentration: NaN
is encoded by: hsa:51166
boundary condition: true
constant: false
name: AADAT
is: SBO:0000252
is: Q8N5Z0
initial amount: NaN
type: Species
has only substance units: false

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_366111b5_8159_4535_9048_00f7f69680f7
type: Species
name: MYO5B
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4645
boundary condition: true
has only substance units: false
is: Q9H6Y6
constant: false
initial amount: NaN

metaM ksi deg38 l
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: HMDB00143
is: CHEBI:12936
type: Species
boundary condition: false
name: keratan sulfate I, degradation product 38

http://identifiers.org/biomodels.db/MODEL1310110010#_8a0dcf46_2b29_4cbe_bb4c_7be301c46437
has only substance units: false
boundary condition: true
is encoded by: hsa:3417
is: O75874
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: IDH1

metaR r1596
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_7472bb02_323a_4c18_ba08_6c2fec0584b8
is: Q14642
has only substance units: false
name: INPP5A
initial concentration: NaN
type: Species
is encoded by: hsa:3632
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_3a61b907_b447_4094_a3e7_549880bae098
is encoded by: hsa:4718
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: NDUFC2
is: SBO:0000252
initial amount: NaN
is: Q549M5
has only substance units: false

metaR LNSTLSr
name: lanosterol synthase
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000134
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/5.4.99.7
type: Reaction
is: SBO:0000176
product: MODEL1310110010#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_999857d0_766c_45bd_a6c9_6a093e119dfb
is: SBO:0000252
initial amount: NaN
name: LDHAL6B
constant: false
has only substance units: false
initial concentration: NaN
is: Q9BYZ2
type: Species
is encoded by: hsa:92483
boundary condition: true

metaR GLYtm
reactant: MODEL1310110010#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
type: Reaction
name: glycine passive transport to mitochondria
reversible: true

metaR CYSTA
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000304
type: Reaction
name: cysteine transaminase
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
is: SBO:0000176

metaM h m
is: SBO:0000247
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3380
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110010#_9d638fa3_607e_4b9e_bdb9_b2bb65a43eff
constant: false
is encoded by: hsa:124
type: Species
is: P07327
name: ADH1A
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR FAOXC2251836x
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110010#
name: Beta oxidation of long chain fatty acid

metaR CHSTEROLt1
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
reversible: true
kinetic law: MODEL1310110010#
fast: false
name: cholesterol intracellular transport
product: MODEL1310110010#
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_5fcaacc7_0dc3_49c3_b576_00c37f36cd70
name: _U37519_1_e
initial amount: NaN
is encoded by: hsa:U37519
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM pmtcrn c
initial concentration: 1.0
is: HMDB00222
boundary condition: false
constant: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:17490
initial amount: NaN

metaM pchol hs c
name: Phosphatidylcholine
initial amount: NaN
is: CHEBI:16110
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false

metaR r1595
is: SBO:0000185
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000000
fast: false

metaR MAGt
is described by: ECO:0000269
type: Reaction
reversible: true
kinetic law: MODEL1310110010#
name: monoacylglycerol 2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
fast: false
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_13ae52fb_f0da_447d_85c3_01c07dcef1d9
is encoded by: hsa:2181
constant: false
name: ACSL3
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: B3KMA6
has only substance units: false

metaR DNDPt10m
reversible: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
name: dADP transport via dCDP antiport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110010#
fast: false
type: Reaction

metaR PUNP6
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110010#
name: purine-nucleoside phosphorylase (Deoxyinosine)
fast: false
product: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110010#

metaR CHSTEROLt2
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110010#
is: SBO:0000185
name: cholesterol intracellular transport
fast: false
reversible: true
type: Reaction

metaR r0747
modifier: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110010#
is described by: ECO:0000000
reversible: true
fast: false

metaR r0407
kinetic law: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
reversible: true
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110010#
reactant: MODEL1310110010#

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR GRTTx
is: SBO:0000176
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reactant: MODEL1310110010#
name: geranyltranstransferase
reversible: false
kinetic law: MODEL1310110010#
is described by: ECO:0000134
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.1
product: MODEL1310110010#

metaR S6TASE10ly
fast: false
reversible: true
name: galactose-6-sulfate sulfatase, lysosomal
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR RE2625C
is: SBO:0000176
type: Reaction
name: RE2625
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaM h l
has only substance units: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
is: SBO:0000247
name: proton
initial concentration: 1.0
type: Species
constant: false
is: C00080
initial amount: NaN

metaM na1 r
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
name: sodium(1+)
type: Species
constant: false
is: HMDB00588
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:29101

metaM dgchol x
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00637
has only substance units: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
initial amount: NaN
constant: false
name: glycochenodeoxycholate
is: CHEBI:36252

metaR r1638
kinetic law: MODEL1310110010#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM mlthf c
is: CHEBI:15636
is: C00143
name: 5,10-Methylenetetrahydrofolate
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB01533
is: SBO:0000247

metaR UMPK5n
modifier: MODEL1310110010#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
name: UMP kinase (dATP),nuclear
reactant: MODEL1310110010#
is: SBO:0000176

metaR CREATt4 2 r
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: Creatine transport (sodium symport) (2:1)
reversible: true
is: SBO:0000185

metaR MERCPLACCYSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_5fd5ac5a_b0f8_4679_95bc_986e66f6d0c8
initial amount: NaN
is: Q86VV3
is encoded by: hsa:953
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: ENTPD1

metaR r0283
modifier: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.157
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.1.6
kinetic law: MODEL1310110010#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (AA676725.1) or (196951.1) or (2584.1) or (2585.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 6.3.2.11 Confidence Level: 0 AUTHORS: PMID:448355,PMID:487087 NOTES:
name: L-Histidine:beta-alanine ligase (AMP-forming) Alanine and aspartate metabolism / Histidine metabolism / beta-Alanine metabolism EC:6.3.2.11

http://identifiers.org/biomodels.db/MODEL1310110010#_bebe0769_3c11_4e5b_ada9_d17319418358
has only substance units: false
initial amount: NaN
is encoded by: hsa:5244
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P21439
name: ABCB4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_bc2619df_93bc_47c5_97ea_67436390c0ab
initial concentration: NaN
is encoded by: hsa:5335
is: P19174
name: PLCG1
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaR r1594
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM acgalfucgalacglcgalgluside hs g
is: SBO:0000247
is: CHEBI:57847
boundary condition: false
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species
name: Type IA glycolipid
constant: false
is: HMDB00304
has only substance units: false

metaR BTNPLm
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
type: Reaction
fast: false
reversible: false
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110010#
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_3025a5c1_b8cc_4da5_b682_9401b83973b3
is: Q5JPH6
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
name: EARS2
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:124454

metaR O2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110010#
fast: false
name: o2 transport (diffusion)

metaR CHSTEROLt3
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110010#
is: SBO:0000185
name: cholesterol intracellular transport
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_9e2e2a83_9320_4a79_a1c9_b21a35e3f8d3
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
name: GCDH
is: SBO:0000252
is encoded by: hsa:2639
initial amount: NaN
is: Q92947
constant: false

metaR PUNP7
reversible: true
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Xanthosine)
reactant: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
type: Reaction
is: SBO:0000176

metaR O2ter
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
name: O2 transport, endoplasmic reticulum
fast: false
reactant: MODEL1310110010#

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaR RE2988X
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
name: RE2988
product: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reversible: true

metaR ACONTm
reactant: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
name: Aconitate hydratase
fast: false
type: Reaction
is described by: ECO:0000134
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_92cc7168_c22b_4cd6_b755_57905463051a
initial concentration: NaN
name: GCDH
has only substance units: false
boundary condition: true
is encoded by: hsa:2639
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

metaM ksii core2 pre9 g
constant: false
has only substance units: false
is: CHEBI:28067
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
type: Species
name: keratan sulfate II biosynthesis, precursor 9
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_4975e1fa_0ee2_4176_bf34_4f62c71ebb47
type: Species
name: HSD17B4
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3295
is: E9PB82
constant: false

metaR r0853
reactant: MODEL1310110010#
type: Reaction
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
reversible: false
product: MODEL1310110010#
is: SBO:0000185

metaR r1639
type: Reaction
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000

metaR 4HGLSDm
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reversible: true
fast: false
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
modifier: MODEL1310110010#
is described by: ECO:0000212
is: SBO:0000176
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.12

metaM Sfglutth c
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
constant: false
is: CHEBI:57688
initial amount: NaN
boundary condition: false
type: Species
name: S-formylglutathionate(1-)
initial concentration: 1.0
is: HMDB01550
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_5a30d0db_cb39_4d1e_8be8_ed11cb8a36f9
is: E9PCI1
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: ACP2
constant: false
is encoded by: hsa:53
has only substance units: false

metaR FAOXC140
is described by: ECO:0000269
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110010#
modifier: MODEL1310110010#
name: Beta oxidation of long chain fatty acid
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM pchol hs e
boundary condition: false
initial amount: NaN
type: Species
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: CHEBI:16110
has only substance units: false
constant: false
is: SBO:0000247

metaM HC01118 r
boundary condition: false
is: CHEBI:57310
constant: false
initial amount: NaN
name: presqualene diphosphate(3-)
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
initial concentration: 1.0

metaR r1593
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110010#_0ba26797_6f7f_4679_8803_93b02c8011e6
name: TST
is: SBO:0000252
constant: false
is encoded by: hsa:7263
type: Species
initial concentration: NaN
boundary condition: true
is: Q16762
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_f37251b8_a669_498d_b5a2_a3250d6eb5aa
initial amount: NaN
boundary condition: true
is: E9PEN2
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: MGAT4A
type: Species
is encoded by: hsa:11320

http://identifiers.org/biomodels.db/MODEL1310110010#_ba70b564_304b_4eed_b9c5_a0c811d13a41
is encoded by: hsa:23428
constant: false
initial concentration: NaN
is: Q9UHI5
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC7A8
type: Species

metaR r1658
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_f51aec99_faef_4e79_9d5a_178100c646a2
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:1103
type: Species
is: Q6LEN5
boundary condition: true
initial concentration: NaN
name: CHAT
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_abfb4093_96a7_42b3_a315_7992ea331c32
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: CHAT
is encoded by: hsa:1103
is: P28329
has only substance units: false

metaR FAS120COA
is: SBO:0000176
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
name: fatty-acyl-CoA synthase (n-C12:0CoA)
product: MODEL1310110010#

metaR RE3556C
is: SBO:0000176
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#
reversible: true
name: RE3556
fast: false
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_618d957e_88da_41c6_a13a_6cd63cef9619
name: ALDH3B2
has only substance units: false
type: Species
boundary condition: true
is: P48448
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:222
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_4fa080a3_b677_4252_8a33_d76374e3923f
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7371
name: UCK2
initial amount: NaN
is: Q9BZX2
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_b4e9c7a3_dfcb_4578_8299_7446272a7b25
type: Species
is encoded by: hsa:131669
initial amount: NaN
boundary condition: true
is: Q68CJ7
has only substance units: false
is: SBO:0000252
constant: false
name: UROC1
initial concentration: NaN

metaR r1636
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false

metaM 13dpg c
name: 3-Phospho-D-glyceroyl phosphate
type: Species
is: http://identifiers.org/pubchem.compound/3535
has only substance units: false
is: C00236
is: CHEBI:57604
initial amount: NaN
is: HMDB01270
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: SBO:0000247
constant: false

metaR SIAASE4ly
reversible: false
reactant: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
name: sialidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110010#_0e961dc3_34fe_4587_95dd_4269b5ad4735
initial concentration: NaN
constant: false
is encoded by: hsa:AI091231
is: SBO:0000252
name: _AI091231_1_c
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_c80ed7fa_6380_46e1_9aca_1ab2078e9fbb
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6307
name: MSMO1
type: Species
is: A8MYF6

metaM arachd x
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01043
has only substance units: false
is: CHEBI:32395
initial amount: NaN

metaM succ m
initial concentration: 1.0
has only substance units: false
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031
is: SBO:0000247
name: Succinate
initial amount: NaN
is: C00042
constant: false
boundary condition: false
type: Species

metaR r0281
reversible: true
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
product: MODEL1310110010#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/5.3.1.6
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000

metaR ENGASEly
is: SBO:0000176
type: Reaction
reactant: MODEL1310110010#
name: endo-beta-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
reversible: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110010#
fast: false

metaM mal L m
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: HMDB00156
has only substance units: false
type: Species
name: (S)-malate(2-)
initial amount: NaN

metaR r0400
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
reversible: true
reactant: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4

metaR S6T15g
reactant: MODEL1310110010#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.21
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.17
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD

metaM xol7aone c
constant: false
is: CHEBI:17899
type: Species
is: SBO:0000247
boundary condition: false
name: 7alpha-hydroxycholest-4-en-3-one
initial amount: NaN
has only substance units: false
is: HMDB01993
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455

metaR r1659
reversible: true
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#

metaM ksii core2 pre2 g
constant: false
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 2
is: CHEBI:58053
has only substance units: false
is: C00130
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_748fad78_4017_47f2_8b20_269527e8988c
has only substance units: false
initial amount: NaN
is encoded by: hsa:8527
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: Q16760
name: DGKD

metaM orn e
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:0
is: HMDB00214
initial concentration: 1.0
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
initial amount: NaN
is: C01602
has only substance units: false
constant: false

metaR r1020
is: SBO:0000185
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110010#
name: Postulated transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_3cda2ab9_0019_471b_86ac_c1a9df98fdd8
initial amount: NaN
is encoded by: hsa:2222
boundary condition: true
is: P37268
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: FDFT1
constant: false

metaM hexccoa x
name: Hexacosanoyl-CoA (n-C26:0CoA)
is: HMDB06459
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR r1599
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
type: Reaction
reversible: true
product: MODEL1310110010#

metaM ksi pre30 g
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00175
constant: false
initial amount: NaN
is: C00130
type: Species
name: keratan sulfate I biosynthesis, precursor 30
is: CHEBI:58053
notes: FORMULA: C219H350N15O184S9X CHARGE: -10

metaR r1637
kinetic law: MODEL1310110010#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_f6555a78_7c2d_4797_b011_44b376392989
type: Species
initial amount: NaN
has part: P00338
is encoded by: hsa:3945
boundary condition: true
name: LDHA:LDHB
is encoded by: hsa:3939
initial concentration: NaN
has part: P07195
has only substance units: false
is: SBO:0000297
constant: false

metaR r0629
is version of: http://identifiers.org/ec-code/3.6.1.22
reversible: true
modifier: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_1eb4949d_1ebf_4f91_9f9c_825d2d50754a
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
name: FOLR1
is encoded by: hsa:2348
initial concentration: NaN
initial amount: NaN

metaR r2380
is: SBO:0000185
product: MODEL1310110010#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_1ce6ab2b_9e33_4b58_91fb_39f5c1457dff
name: BAAT
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:570
constant: false
boundary condition: true
initial amount: NaN
is: Q14032

metaM chsterol r
is: SBO:0000247
is: CHEBI:16113
has only substance units: false
is: HMDB00067
type: Species
name: cholesterol
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false
initial concentration: 1.0
boundary condition: false

metaR TTDCAtr
reversible: true
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110010#
product: MODEL1310110010#
name: tetradecanoate (transport)
kinetic law: MODEL1310110010#

metaR H2Otly
fast: false
is: SBO:0000185
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
kinetic law: MODEL1310110010#
name: H2O transport, lysosomal
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000000

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_3ed73c2d_033e_4d30_948a_aaa6495ecdb3
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: SGPP1
is encoded by: hsa:81537
constant: false
is: SBO:0000252
is: Q9BX95
has only substance units: false

metaR GLYCTDle
kinetic law: MODEL1310110010#
type: Reaction
name: difussion of glycerol accross the brush border membrane
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#

metaR PE HSter
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: phosphatidylethanolamine scramblase
product: MODEL1310110010#

metaR r0340
fast: false
kinetic law: MODEL1310110010#
type: Reaction
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.38
modifier: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:

metaM o2s m
constant: false
is: HMDB02168
type: Species
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
has only substance units: false
is: CHEBI:18421
boundary condition: false
name: Superoxide anion
is: C00704
is: SBO:0000247
initial amount: NaN

metaM udpacgal c
is: CHEBI:57847
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species
constant: false
is: SBO:0000247
is: HMDB00304

http://identifiers.org/biomodels.db/MODEL1310110010#_e890dd43_56e4_4b14_9e30_141aadbed192
is encoded by: hsa:AA526438
name: _AA526438_1_c
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_83aa5129_d053_43bb_99ba_0d554dc125a7
name: AK2
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:204
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

metaR RE0512M
product: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: RE0512
fast: false
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110010#

metaR RE3005M
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
name: RE3005
is: SBO:0000176
product: MODEL1310110010#

metaR r2381
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
product: MODEL1310110010#
type: Reaction
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_7e799a04_8516_404b_aab9_7641b529f7ed
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:55343
name: SLC35C1
has only substance units: false
type: Species
is: B3KQH0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_837183cd_678d_4861_bc19_582bdc121345
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ALDH7A1
is: E7EPT3
is encoded by: hsa:501
type: Species
constant: false
initial concentration: NaN

metaR r1634
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
reversible: true
kinetic law: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_e215703d_e8a0_4b2b_bdd7_c83c7465f52b
initial concentration: NaN
name: ELOVL2
type: Species
is encoded by: hsa:54898
is: Q9NXB9
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

metaM cit c
has only substance units: false
is: CHEBI:16947
boundary condition: false
name: Citrate
initial amount: NaN
initial concentration: 1.0
is: C00158
is: HMDB00094
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158

metaM naglc2p U c
initial amount: NaN
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
has only substance units: false
is: CHEBI:18278
constant: false

metaR r1598
is: SBO:0000185
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1445
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
reactant: MODEL1310110010#
name: EC:1.3.3.6

http://identifiers.org/biomodels.db/MODEL1310110010#_5f500e98_ed4f_4765_84ec_d7f37ba7258b
is encoded by: hsa:6005
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: RHAG
is: Q96E98
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_c972f8f2_6235_48c5_84db_648afaa41811
name: PANK2
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:80025
initial amount: NaN
is: Q6P1K9

metaM hLkynr c
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB11631
name: 3-hydroxy-L-kynurenine
is: CHEBI:17380
constant: false
initial amount: NaN
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
type: Species

metaR TSTSTERONEt
reversible: true
name: Testosterone transport
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185

metaR GALASE3ly
product: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
kinetic law: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR RE2660N
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
name: RE2660
reversible: true
modifier: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:

metaM HC01412 x
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:61405
name: trans-tetradec-2-enoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273

http://identifiers.org/biomodels.db/MODEL1310110010#_d7761025_ceaa_4d48_8b83_e834a9c6d1cb
has only substance units: false
is encoded by: hsa:AI971023
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: _AI971023_1_c

metaR r2382
type: Reaction
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110010#
reversible: false
product: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM h g
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:24636
is: SBO:0000247
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
constant: false

metaR r0627
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
fast: false

metaR r1635
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR r1444
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110010#
fast: false
name: EC:1.3.3.6
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#

metaR r1597
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#

metaM orn c
name: Ornithine
initial amount: NaN
is: SBO:0000247
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C01602
is: CHEBI:0
constant: false
type: Species

metaR OCDCEAtr
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reactant: MODEL1310110010#

metaR CYTK13n
type: Reaction
is: SBO:0000176
modifier: MODEL1310110010#
product: MODEL1310110010#
name: cytidylate kinase (dCMP,dATP),nuclear
fast: false
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_93acb203_ccdf_48f6_b4b4_5644336fecb8
boundary condition: true
is encoded by: hsa:23563
type: Species
initial concentration: NaN
has only substance units: false
name: CHST5
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9GZS9

metaM ksi pre17 g
type: Species
is: CHEBI:28067
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 17
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
is: SBO:0000247

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_462b4955_2d5d_4f31_ac13_c6cb2904145a
type: Species
initial amount: NaN
is encoded by: hsa:5476
has part: P34059
has only substance units: false
is: SBO:0000297
has part: P10619
boundary condition: true
is encoded by: hsa:2720
is encoded by: hsa:2588
name: GALNS:GLB1:NEU1:CTSA
is encoded by: hsa:4758
has part: P16278
constant: false
has part: Q99519
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_44a76aa2_8306_47b4_ba67_a1cfe81b2702
boundary condition: true
type: Species
is encoded by: hsa:38
is: P24752
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ACAT1
constant: false
initial amount: NaN

metaR PGCD
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: phosphoglycerate dehydrogenase
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.95
is described by: ECO:0000269

metaM mev R c
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
initial amount: NaN
is: HMDB00227
constant: false
is: CHEBI:36464
name: (R)-mevalonate
boundary condition: false
initial concentration: 1.0

metaM hco3 e
type: Species
constant: false
is: C00288
is: SBO:0000247
is: CHEBI:17544
has only substance units: false
initial amount: NaN
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
name: Bicarbonate
boundary condition: false
initial concentration: 1.0
is: HMDB00595

metaM xoltriol c
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: CHEBI:16496
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
initial amount: NaN
has only substance units: false
is: HMDB01457
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_47b4a9a5_4541_44e0_a241_6d02f32b4320
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:AV727634
type: Species
name: _AV727634_1_c

metaR TETPENT6t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
kinetic law: MODEL1310110010#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#

metaM cit m
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: C00158
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:16947
initial concentration: 1.0
name: Citrate
is: HMDB00094
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_0ce0f57a_d56d_45b6_928e_7b403afc661c
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9NVE7
initial concentration: NaN
is encoded by: hsa:55229
boundary condition: true
name: PANK4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_5830d4ff_4e34_43be_8f00_71b9676987ee
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: P14618
is: SBO:0000252
name: PKM2
initial concentration: NaN
is encoded by: hsa:5315
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_40f3b0f2_5e93_48a1_9f47_de6c883fbe5b
is encoded by: hsa:1347
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: H0UI06
constant: false
name: COX7A2
is: SBO:0000252

metaM mlthf m
is: C00143
initial amount: NaN
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
boundary condition: false
is: SBO:0000247
constant: false
name: 5,10-Methylenetetrahydrofolate
initial concentration: 1.0
type: Species
is: HMDB01533
is: CHEBI:15636
has only substance units: false

metaM uri c
is: CHEBI:16704
is: C00299
boundary condition: false
is: HMDB00296
constant: false
name: Uridine
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN

metaR r1443
is: SBO:0000176
is described by: ECO:0000000
name: EC:1.3.3.6
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:

metaR PRO Dtde
name: D-proline transport, extracellular
is described by: ECO:0000134
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110010#
fast: false
reversible: true

metaR FAOXC80
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is described by: ECO:0000269
product: MODEL1310110010#
fast: false
name: Beta oxidation of med/long chain fatty acid
modifier: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

metaR 4NPHSFte
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
is described by: ECO:0000000
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
reversible: true
name: xenobiotic transport
is: SBO:0000185
type: Reaction

metaM ksii core4 pre3 g
constant: false
notes: FORMULA: C55H89N5O38X CHARGE: -1
type: Species
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false
initial amount: NaN
is: HMDB00175
boundary condition: false
is: SBO:0000247
is: C00130
name: keratan sulfate II biosynthesis, precursor 3

http://identifiers.org/biomodels.db/MODEL1310110010#_d7264093_e98c_4d2a_815e_3b64d365fe10
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1103
type: Species
name: CHAT
is: Q6LEN6
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

metaR r0741
fast: false
reactant: MODEL1310110010#
type: Reaction
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
product: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
modifier: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m

metaR NDPK6m
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
type: Reaction
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000254
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_740cfbeb_d33b_4e97_b889_1d936f37f0a9
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: TXNRD1
is encoded by: hsa:7296
constant: false
initial concentration: NaN
is: Q16881

metaR G14T15g
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110010#

metaM lpam m
is: SBO:0000247
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00962
is: CHEBI:17460
constant: false
has only substance units: false
name: lipoamide
initial concentration: 1.0

metaR SPHK21c
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
name: sphingosine kinase 2
product: MODEL1310110010#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.91
fast: false

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaM h e
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
is: C00080
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: CHEBI:24636
type: Species
is: SBO:0000247
name: proton

metaR r2384
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
reversible: false

metaR PUNP1
is: SBO:0000176
name: purine-nucleoside phosphorylase (Adenosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
product: MODEL1310110010#

metaR OCCOAtm
kinetic law: MODEL1310110010#
fast: false
type: Reaction
product: MODEL1310110010#
name: Octanoyl-CoA transport, diffusion
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: false
is: SBO:0000185
is described by: ECO:0000000

metaM apoC Lys btn m
notes: FORMULA: C16H27N4O3SX CHARGE: 0
has only substance units: false
type: Species
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C05552
is: HMDB03134
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886

metaR GLUDxm
modifier: MODEL1310110010#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110010#
name: glutamate dehydrogenase (NAD) (mitochondrial)
kinetic law: MODEL1310110010#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.4.1.3
reversible: true

metaR P5CDm
type: Reaction
modifier: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
is described by: ECO:0000269

metaM mi134p c
is: HMDB01143
is: CHEBI:58414
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
has only substance units: false
is: SBO:0000247
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
type: Species
constant: false

metaM accoa g
initial amount: NaN
boundary condition: false
is: CHEBI:57288
type: Species
is: HMDB01206
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: SBO:0000247
has only substance units: false
name: acetyl-CoA(4-)

metaM uri e
is: SBO:0000247
type: Species
is: HMDB00296
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C00299
name: Uridine
is: CHEBI:16704

metaM fadh2 c
type: Species
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
is: CHEBI:58307
name: FADH2(2-)
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01197
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_8810e6bc_64ca_4d54_aa52_1e50a0525898
name: _T83654_1_m
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:T83654
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_0670fc86_980d_4e80_9344_0471a023faf3
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55902
is: Q5QPH3
boundary condition: true
name: ACSS2
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_d2d6b442_3033_4f9a_8687_1bce6114df0c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AV717590
initial concentration: NaN
constant: false
boundary condition: true
name: _AV717590_1_c
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_cc29e9fd_22c4_4b92_a714_a865a83d6135
initial concentration: NaN
is: O43820
is encoded by: hsa:8372
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: HYAL3

http://identifiers.org/biomodels.db/MODEL1310110010#_8cdf8c49_0622_41b7_8ce7_cd7c41a86b7f
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI824319
type: Species
constant: false
name: _AI824319_1_r
initial amount: NaN
initial concentration: NaN

metaR r1377
type: Reaction
reversible: true
fast: false
product: MODEL1310110010#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is: SBO:0000176
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_72308de5_3aee_4d54_a97b_5d02320916f2
initial concentration: NaN
type: Species
is: O95169
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4714
name: NDUFB8

http://identifiers.org/biomodels.db/MODEL1310110010#_67f9cd38_f917_4df2_88af_1f2daca6bf15
name: PANK4
boundary condition: true
is: Q9NVE7
is encoded by: hsa:55229
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM rbt c
is: HMDB00508
is: CHEBI:15963
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
constant: false
name: D-ribitol
is: SBO:0000247
type: Species

metaR r2385
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
modifier: MODEL1310110010#
is described by: ECO:0000000
fast: false

metaR r0552
reversible: true
modifier: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110010#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8

metaR r0345
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
reversible: true
modifier: MODEL1310110010#

metaR RE1901R
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110010#
name: RE1901
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
reactant: MODEL1310110010#
product: MODEL1310110010#

metaR AG13T6g
kinetic law: MODEL1310110010#
reversible: false
fast: false
is described by: ECO:0000000
modifier: MODEL1310110010#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_fb247139_8cf5_473b_a92d_d5d11b4b7866
is encoded by: hsa:8869
name: ST3GAL5
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: Q9UNP4
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_d5417e40_379f_484d_83b8_a64f0b2f20b9
initial concentration: NaN
is: SBO:0000252
is: P26439
name: HSD3B2
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:3284

metaR BALAPAT1tc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine by PAT1 in renal and intestinal cells
type: Reaction

metaR DOLPMT2 Uer
reversible: false
product: MODEL1310110010#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110010#

metaM rbt e
name: D-ribitol
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:15963
is: HMDB00508

metaR r1378
reactant: MODEL1310110010#
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_51a60a93_375f_4437_8c08_4ba54325238a
is encoded by: hsa:8803
has only substance units: false
name: SUCLA2
type: Species
initial amount: NaN
is: E5KS60
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_b96fc6e6_8156_40dd_bb7e_8b075bc7ace3
is: SBO:0000252
is: P16278
type: Species
has only substance units: false
boundary condition: true
name: GLB1
constant: false
is encoded by: hsa:2720
initial amount: NaN
initial concentration: NaN

metaR PROD2m
is described by: ECO:0000254
is: SBO:0000176
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
fast: false
type: Reaction
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.5.99.8
name: Proline dehydrogenase (m)
reactant: MODEL1310110010#
reversible: false
product: MODEL1310110010#

metaM h c
initial concentration: 1.0
initial amount: NaN
name: proton
constant: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380

metaR MG3er
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reactant: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#

metaR PROt4 2 r
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110010#
is described by: ECO:0000006
reversible: true
name: Proline transport (sodium symport) (2:1)
is: SBO:0000185
modifier: MODEL1310110010#
fast: false

metaM ksi pre20 g
initial concentration: 1.0
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:28067
type: Species
name: keratan sulfate I biosynthesis, precursor 20
has only substance units: false

metaR r2386
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reversible: false
is: SBO:0000185

metaM 2hb e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
constant: false
is: HMDB00008
name: 2-Hydroxybutyrate
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:1148

metaR KSII CORE2t
reactant: MODEL1310110010#
type: Reaction
fast: false
is: SBO:0000185
reversible: false
name: keratan sulfate II (core2) transport, golgi to extracellular
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110010#
is described by: ECO:0000000

metaM gullac r
constant: false
is: HMDB03466
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:17587
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
name: L-gulono-1,4-lactone
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM mal L e
has only substance units: false
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial amount: NaN
constant: false
name: (S)-malate(2-)
is: CHEBI:15589
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00156

metaM tchola x
is: HMDB00036
is: SBO:0000247
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial amount: NaN
boundary condition: false
name: taurocholate
initial concentration: 1.0
is: CHEBI:36257
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_93c3cb5d_6d11_47dc_af56_64850adb475b
is encoded by: hsa:1737
name: DLAT
constant: false
is: Q86YI5
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23

http://identifiers.org/biomodels.db/MODEL1310110010#_53e52bb6_7842_4d8a_b0b3_16b5337800ca
name: PNPO
is: SBO:0000252
is encoded by: hsa:55163
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9NVS9
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_d486fd68_c9a2_4166_8cc5_6392fbafd92f
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:8034
name: SLC25A16
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P16260
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_c761d84c_21d5_478f_8060_18c0a1d22abd
name: PRDX3
constant: false
is encoded by: hsa:10935
initial amount: NaN
is: P30048
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaM ksi pre26 g
is: CHEBI:28067
is: SBO:0000247
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 26
initial amount: NaN
type: Species
boundary condition: false
constant: false

metaR NADPHtru
reversible: false
reactant: MODEL1310110010#
name: NADPH transporter, endoplasmic reticulum
kinetic law: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ

metaR r2387
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110010#
is described by: ECO:0000000
fast: false

metaM pail45p hs n
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:28910
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_42725c99_4d5b_4422_9fac_3427e6dd7384
boundary condition: true
type: Species
is encoded by: hsa:65263
has only substance units: false
initial concentration: NaN
name: PYCRL
is: SBO:0000252
constant: false
is: Q53H96
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_989f92eb_6f1e_4193_bf7e_cc921d22194f
boundary condition: true
type: Species
is encoded by: hsa:171425
name: CLYBL
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR PUNP4
kinetic law: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Deoxyguanosine)
product: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR ATPtm
name: ADP/ATP transporter, mitochondrial
is: SBO:0000185
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD

metaR MI13PP
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: inositol-1,3-bisphosphate 3-phosphatase
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_30c822af_ccaf_4819_a06e_2bf5453f1960
is encoded by: hsa:AW299740
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AW299740_1_m
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_c4c53a04_43ae_4fd8_9880_874307b1ce4b
boundary condition: true
type: Species
initial concentration: NaN
has part: Q86U05
constant: false
is: SBO:0000297
name: SLC7A8:SLC3A2
is encoded by: hsa:23428
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_59b228c6_1b5a_4346_8cdf_711a267ae766
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:158
has only substance units: false
is: SBO:0000252
name: ADSL
is: P30566
type: Species
boundary condition: true

metaM ppa c
boundary condition: false
is: CHEBI:17272
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: propionate
is: HMDB00237
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163

metaM ocdca c
name: stearate
type: Species
is: SBO:0000247
is: CHEBI:25629
is: HMDB00827
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial amount: NaN
constant: false

metaR G14T7g
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR ACHEe
name: Acetylcholinesterase
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.7
is: SBO:0000176
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000269
modifier: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ

metaM cysam c
has only substance units: false
initial concentration: 1.0
is: HMDB02991
initial amount: NaN
type: Species
constant: false
is: CHEBI:58029
is: SBO:0000247
name: cysteaminium
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
boundary condition: false

metaR SUCOAS1m
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
product: MODEL1310110010#
name: Succinate--CoA ligase (GDP-forming)
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
type: Reaction
reversible: true
is: SBO:0000176

metaR SPMTDe
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110010#
is: SBO:0000185
reversible: true
is described by: ECO:0000134
name: SPMTDe
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_72975b89_f237_496e_8c28_987b44a0237c
is: Q96KN2
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:84735
initial amount: NaN
boundary condition: true
name: CNDP1
has only substance units: false

metaR GTHRDt
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
type: Reaction
kinetic law: MODEL1310110010#
name: Glutathione transport into mitochondria
reactant: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaM so4 e
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: sulfate
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
initial concentration: 1.0
is: CHEBI:16189
initial amount: NaN

metaR r0553
type: Reaction
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
fast: false

metaR r2388
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_1fadaaad_3fc3_4b22_a04a_81e91456c29b
name: FDFT1
constant: false
is: P37268
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2222
has only substance units: false
initial amount: NaN

metaM xol25oh r
is: CHEBI:42977
is: SBO:0000247
has only substance units: false
is: HMDB06247
type: Species
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
constant: false
initial concentration: 1.0
initial amount: NaN
name: 25-hydroxycholesterol

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaR PItg
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110010#
fast: false
reversible: false
reactant: MODEL1310110010#
name: phosphate transport, Golgi apparatus
product: MODEL1310110010#
is described by: ECO:0000000

metaR r0408
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reversible: true
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.5
type: Reaction
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_ad564271_e6f1_441f_b681_50adbc869612
has only substance units: false
constant: false
is: Q308M7
initial amount: NaN
name: ENPP3
boundary condition: true
is encoded by: hsa:5169
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_014e0aa1_24cd_4f63_8d5b_594e900d2d36
type: Species
name: FOLR1
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:2348
has only substance units: false
constant: false
is: SBO:0000252

metaR GLYATm
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000254
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.29
notes: GENE_ASSOCIATION: (23464.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.29 Confidence Level: 2 AUTHORS: PMID:10712613 NOTES:
is: SBO:0000176
product: MODEL1310110010#
fast: false
type: Reaction
name: glycine C-acetyltransferase

metaM CE5162 r
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
boundary condition: false
is: CHEBI:12947
is: SBO:0000247
name: trans,cis-2,9-octadecadienoyl-CoA

metaM mal L c
is: SBO:0000247
is: HMDB00156
type: Species
initial amount: NaN
name: (S)-malate(2-)
constant: false
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: CHEBI:15589
boundary condition: false
has only substance units: false

metaR TMDS
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
product: MODEL1310110010#
type: Reaction
name: thymidylate synthase
is version of: http://identifiers.org/ec-code/2.1.1.45
modifier: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
fast: false

metaR KSII CORE4tly
is: SBO:0000185
kinetic law: MODEL1310110010#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
reversible: false
name: keratan sulfate II (core 4) transport, extracellular to lysosome

metaM CE5586 c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
constant: false
boundary condition: false
type: Species
is: CHEBI:58732
is: SBO:0000247
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586

metaM HC01444 e
boundary condition: false
constant: false
is: CHEBI:15754
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: Galactosylglycerol
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401

metaR r2389
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
modifier: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110010#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_11a228a7_252d_44ab_b801_8733bb0d21bf
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is: Q9BY49
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55825
name: PECR
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_06c23ea6_c1d5_4946_8bf7_44dd7dc66d64
is: SBO:0000252
is encoded by: hsa:LOC727762
constant: false
type: Species
has only substance units: false
name: _LOC727762_1_m
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM accoa c
is: HMDB01206
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
is: C00024
is: SBO:0000247
is: CHEBI:57288
boundary condition: false
name: Acetyl-CoA
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_b1e54fe3_f55a_44ed_b273_a5f14718c5eb
initial amount: NaN
is encoded by: hsa:2643
boundary condition: true
type: Species
is: Q8IZH9
initial concentration: NaN
has only substance units: false
name: GCH1
constant: false
is: SBO:0000252

metaM succ c
initial concentration: 1.0
is: C00042
name: Succinate
constant: false
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:30031
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaR r0743
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
type: Reaction
is: SBO:0000176
fast: false
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:

metaR r0556
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
modifier: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.19.1
reversible: true
kinetic law: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_9c460e85_a992_4ece_9779_04e5e27d9036
type: Species
has only substance units: false
is: Q9NP59
is encoded by: hsa:30061
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC40A1

metaR PROSTGD2t
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
modifier: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
reversible: true

metaR M8MASNterg
type: Reaction
name: m8masn transport from ER to Golgi apparatus
fast: false
reactant: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD
product: MODEL1310110010#

metaM ksi deg2 l
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: keratan sulfate I, degradation product 2
constant: false
boundary condition: false
is: HMDB01356
is: CHEBI:57312

metaR BAAT4x
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110010#
is described by: ECO:0000304
type: Reaction
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
reactant: MODEL1310110010#
name: bile acid Coenzyme A: amino acid N-acyltransferase

http://identifiers.org/biomodels.db/MODEL1310110010#_c19fe296_40dd_4144_9d2b_7b0aa81bc10e
constant: false
type: Species
name: _AGPAT7_1_c
has only substance units: false
is encoded by: hsa:AGPAT7
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM ppa e
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: HMDB00237
type: Species
is: SBO:0000247
name: propionate
initial concentration: 1.0

metaM CE5786 e
is: HMDB02710
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
type: Species
name: kinetensin
is: SBO:0000247
is: CHEBI:27485
has only substance units: false

metaR TYRTA
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
fast: false
is described by: ECO:0000269
product: MODEL1310110010#
name: tyrosine transaminase
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_afcdc0d3_ee9a_4f22_835c_bda012b215c6
name: PPCS
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:79717
initial concentration: NaN
is: Q9HAB8

metaM cysam e
is: HMDB02991
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
type: Species
is: CHEBI:58029
name: cysteaminium
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1
boundary condition: false

metaM pail hs c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial amount: NaN
is: CHEBI:57880
type: Species
constant: false

metaM methf m
is: HMDB01354
constant: false
boundary condition: false
name: (6R)-5,10-methenyltetrahydrofolate
is: SBO:0000247
type: Species
is: CHEBI:57455
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM so4 c
initial amount: NaN
has only substance units: false
is: HMDB01448
constant: false
boundary condition: false
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
type: Species
is: SBO:0000247
name: sulfate

metaR r0744
type: Reaction
is: SBO:0000176
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
is described by: ECO:0000000
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
fast: false
kinetic law: MODEL1310110010#

metaR PUNP3
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
name: purine-nucleoside phosphorylase (Guanosine)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_9423a0b3_00d7_41c3_b8de_6d6e0abec1bb
initial amount: NaN
type: Species
is: P00915
is encoded by: hsa:759
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: CA1

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110010#
reversible: true
fast: false
modifier: MODEL1310110010#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito

metaM dhcholestancoa x
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
boundary condition: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:15494
is: HMDB02159

metaM arachdcoa x
initial concentration: 1.0
is: HMDB06523
is: SBO:0000247
is: CHEBI:57368
constant: false
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species
initial amount: NaN
has only substance units: false
name: arachidonoyl-CoA(4-)

metaM man6p c
type: Species
is: HMDB01078
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: D-Mannose 6-phosphate
is: CHEBI:17369
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275

metaR SERDGLYexR
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
name: D-Serine/Glycine reversible exchange
reactant: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
reversible: true
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaM prostge1 c
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57397
is: SBO:0000247
constant: false
has only substance units: false
type: Species
name: prostaglandin E1(1-)
is: HMDB01442

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR r0970
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110010#
reactant: MODEL1310110010#
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110010#_106fd9a2_4432_423e_b8d0_2d096546fc4e
is encoded by: hsa:4830
name: NME1
has only substance units: false
type: Species
constant: false
is: P15531
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM HC01231 m
is: SBO:0000247
is: CHEBI:58480
name: N-[(R)-pantothenoyl]-L-cysteinate
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079

metaR LYStn
reversible: true
product: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
name: L-lysine transport, nuclear
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_16ff2139_761d_429d_84da_3a65d41dc1f4
is: Q9NR34
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:57134
boundary condition: true
name: MAN1C1
type: Species
initial amount: NaN

metaM xol7aone m
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: HMDB01993
initial concentration: 1.0
initial amount: NaN
name: 7alpha-hydroxycholest-4-en-3-one

metaM 1p3h5c m
is: SBO:0000247
boundary condition: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
has only substance units: false
is: HMDB01369
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: CHEBI:6151

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR UMPKn
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000176
type: Reaction
name: UMP kinase, nuclear
reactant: MODEL1310110010#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_92d08432_d31d_4acf_8f8d_1e64e47435c3
initial amount: NaN
name: ALDH1B1
is: P30837
has only substance units: false
boundary condition: true
is encoded by: hsa:219
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaM m8masn g
constant: false
is: SBO:0000247
notes: FORMULA: C70H117N2O55X CHARGE: 0
initial concentration: 1.0
boundary condition: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
type: Species
has only substance units: false
is: C05876

http://identifiers.org/biomodels.db/MODEL1310110010#_0e148908_8730_405d_a055_a7a6a97b91de
boundary condition: true
initial amount: NaN
name: HAS2
constant: false
type: Species
initial concentration: NaN
is: Q92819
is encoded by: hsa:3037
has only substance units: false
is: SBO:0000252

metaM ocdca e
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: octadecanoate (n-C18:0)
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: C01530
type: Species
boundary condition: false
is: CHEBI:25629
is: HMDB00827
initial concentration: 1.0

metaR r1661
type: Reaction
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110010#

metaM pectintchol e
has only substance units: false
type: Species
boundary condition: false
name: pectin-taurocholic acid complex
is: HMDB03402
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C2561H3555NO2542S CHARGE: 0
is: SBO:0000247

metaM ile L e
is: HMDB00172
name: L-isoleucine
constant: false
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:17191

metaR RE3567C
is: SBO:0000176
name: RE3567
reactant: MODEL1310110010#
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_4da12523_87d6_4b4e_8053_621ad5a29719
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4729
initial amount: NaN
boundary condition: true
is: P19404
name: NDUFV2
type: Species
initial concentration: NaN
constant: false

metaM succ x
is: SBO:0000247
name: Succinate
is: CHEBI:30031
has only substance units: false
initial concentration: 1.0
is: C00042
is: HMDB00254
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
initial amount: NaN
boundary condition: false

metaR LYStm
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: Lysine mitochondrial transport via ornithine carrier
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
fast: false
is: SBO:0000185
is described by: ECO:0000269

metaM mag hs c
constant: false
name: monoacylglycerol 2
boundary condition: false
is: CHEBI:16521
is: HMDB01251
initial amount: NaN
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_a753b0df_6240_442a_b5ee_f6217d64b4e8
type: Species
is: P33121
has only substance units: false
is encoded by: hsa:2180
constant: false
is: SBO:0000252
name: ACSL1
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR RTOTAL3t
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110010#
reversible: true
name: RTOTAL3 transport

metaR PCHOLP hs
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: choline phosphatase
kinetic law: MODEL1310110010#
reversible: false
is: SBO:0000176
is described by: ECO:0000269

metaR r2408
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: false

metaM HC00591 c
constant: false
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16769

metaR r2369
is: SBO:0000185
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: Organic anion transporter 5 Utilized transport
reversible: true

metaM xolest2 hs e
initial concentration: 1.0
is: CHEBI:17002
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
name: cholesterol ester

metaM HC01409 m
name: Hexanoyl-CoA
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
boundary condition: false
has only substance units: false
is: CHEBI:27540
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM glx x
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:36655
is: SBO:0000247
has only substance units: false
name: glyoxylate
boundary condition: false

metaR r1660
fast: false
reversible: true
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM inost e
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: myo-inositol
initial concentration: 1.0
is: CHEBI:17268
constant: false
is: HMDB00211

metaM pheacgln c
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:58310
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: HMDB06344
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR URATEt
type: Reaction
reversible: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
product: MODEL1310110010#
name: urate export from cytosol

metaM prostge1 e
initial amount: NaN
name: prostaglandin E1(1-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57397
initial concentration: 1.0
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
has only substance units: false
type: Species
is: HMDB01442

metaR r0545
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
reversible: true
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
reactant: MODEL1310110010#
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_d9b0181f_32bb_4c39_aea6_b52b51b06449
name: SLC25A5
type: Species
is: Q6NVC0
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:292
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r0127
type: Reaction
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110010#
fast: false
is: SBO:0000176
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_98a18d63_db41_46f7_bcfd_c74a81918ba5
has only substance units: false
name: FTCD
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:10841
is: SBO:0000252
constant: false
is: O95954
initial concentration: NaN

metaM xylt c
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial concentration: 1.0
is: CHEBI:17151
is: SBO:0000247
constant: false
type: Species
name: xylitol
initial amount: NaN
has only substance units: false
is: HMDB02917

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM tymsf c
is: SBO:0000247
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
boundary condition: false
is: HMDB06409
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: Tyramine O-sulfate
constant: false

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaR r2054
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110010#

metaM phe L c
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00159
boundary condition: false
type: Species
name: L-phenylalanine
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_3b0d5b54_d61d_4762_aa3c_496be07c9a1e
constant: false
is: SBO:0000252
is: Q9NRA2
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:26503
boundary condition: true
name: SLC17A5
initial amount: NaN

metaM dtdp m
is: HMDB01274
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: dTDP
is: C00363
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
is: CHEBI:58369
is: SBO:0000247

metaM octa e
initial amount: NaN
is: HMDB00482
has only substance units: false
boundary condition: false
constant: false
name: octanoate (n-C8:0)
initial concentration: 1.0
notes: FORMULA: C8H15O2 CHARGE: -1
is: SBO:0000247
is: C06423
type: Species
is: CHEBI:25646

http://identifiers.org/biomodels.db/MODEL1310110010#_96e8697d_b7c4_478e_a7e4_fbafe163cea3
name: _PRO1933_1_m
is: SBO:0000252
is encoded by: hsa:PRO1933
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_4fadbe0b_f83a_4565_a1c7_a77e2a7f84c0
is encoded by: hsa:5959
has only substance units: false
is: SBO:0000252
type: Species
name: RDH5
initial amount: NaN
constant: false
initial concentration: NaN
is: Q92781
boundary condition: true

metaR r2368
name: Organic anion transporter 5 Utilized transport
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110010#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#

metaM gthrd e
type: Species
is: CHEBI:57925
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: glutathionate(1-)
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: HMDB00125
constant: false
has only substance units: false

metaM dhf m
has only substance units: false
type: Species
name: dihydrofolate(2-)
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
initial concentration: 1.0
is: CHEBI:57451
is: HMDB01056
boundary condition: false
initial amount: NaN

metaM hxan e
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial amount: NaN
boundary condition: false
is: CHEBI:17368
has only substance units: false
name: hypoxanthine
is: SBO:0000247
is: HMDB00157
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_10f87de4_2788_4bea_9f5d_c00d3d48324b
initial amount: NaN
type: Species
is: SBO:0000252
name: ABCD1
constant: false
is: P33897
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:215

metaM ile L c
name: L-isoleucine
has only substance units: false
is: HMDB00172
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
is: CHEBI:17191
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaR UDPG4E
reversible: true
name: UDPglucose 4-epimerase
fast: false
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000134
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
is version of: http://identifiers.org/ec-code/5.1.3.2
is: SBO:0000176
product: MODEL1310110010#

metaR r2055
fast: false
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110010#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR HGNTOR
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.5
modifier: MODEL1310110010#
reversible: false
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110010#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_7375c7b7_5bf6_4971_9e60_3aba6f98d11f
type: Species
is: O75912
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: DGKI
boundary condition: true
is encoded by: hsa:9162

metaR GLYCt
name: glycerol transport via channel
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM dtdp n
boundary condition: false
is: HMDB01274
type: Species
initial concentration: 1.0
is: CHEBI:58369
initial amount: NaN
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
is: SBO:0000247

metaR CYTDK1
modifier: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000254
name: ATPcytidine 5-phosphotransferase
kinetic law: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110010#
type: Reaction
fast: false

metaR r2367
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110010#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
name: Organic anion transporter 5 Utilized transport
reversible: true

metaM inost c
is: HMDB00211
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: SBO:0000247
name: myo-inositol
has only substance units: false
type: Species
is: CHEBI:17268

metaM bilirub r
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)
constant: false
initial concentration: 1.0
is: CHEBI:57977
boundary condition: false
type: Species
is: HMDB00054
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR PSSA2 hs
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110010#
name: Phosphatidylserine synthase homo sapiens
is version of: http://identifiers.org/ec-code/2.7.8.29
fast: false
reversible: true
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110010#_8e33dbab_ff77_4d64_8879_a7f1b4d530de
is encoded by: hsa:11181
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is: O43280
initial amount: NaN
name: TREH

http://identifiers.org/biomodels.db/MODEL1310110010#_0b36aa85_c7e1_4de3_b4c1_fda0704fd80f
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: Q86YU0
initial amount: NaN
name: CA7
has only substance units: false
is encoded by: hsa:766

metaM xylt e
is: HMDB02917
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17151
initial amount: NaN
name: xylitol

metaR r1926
fast: false
reactant: MODEL1310110010#
product: MODEL1310110010#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110010#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_726f039f_b80b_46a6_bd94_309883ba855f
is: Q9BY49
boundary condition: true
is encoded by: hsa:55825
has only substance units: false
name: PECR
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaM icit x
name: isocitrate(3-)
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00193
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
constant: false
initial amount: NaN
is: CHEBI:16087
is: SBO:0000247

metaR r0129
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110010#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is described by: ECO:0000000
reactant: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_f6bdefaa_9528_46f5_9c14_0cb302531c0d
initial concentration: NaN
is: Q8NCL4
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:11226
boundary condition: true
name: GALNT6

metaM pheacgln e
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:58310
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB06344
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
type: Species

metaR r0974
reversible: true
is described by: ECO:0000000
name: Active transport
product: MODEL1310110010#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM tymsf e
type: Species
name: Tyramine O-sulfate
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: SBO:0000247
is: HMDB06409
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_db11b97d_639e_4326_a227_f89baa051da1
is: SBO:0000252
is encoded by: hsa:3176
type: Species
initial amount: NaN
is: P50135
has only substance units: false
initial concentration: NaN
name: HNMT
constant: false
boundary condition: true

metaM ksi pre15 g
initial amount: NaN
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: CHEBI:58053
type: Species
name: keratan sulfate I biosynthesis, precursor 15
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: C00130
is: HMDB00175
initial concentration: 1.0

metaR GLCAASE8ly
fast: false
reactant: MODEL1310110010#
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
reversible: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

metaM gthrd c
boundary condition: false
is: CHEBI:57925
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00125
is: C00051
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
initial concentration: 1.0
name: Reduced glutathione

metaR C3STDH1Pr
reversible: false
modifier: MODEL1310110010#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
reactant: MODEL1310110010#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.170
is described by: ECO:0000134

metaM octa c
has only substance units: false
type: Species
is: CHEBI:25646
initial amount: NaN
initial concentration: 1.0
constant: false
name: octanoate (n-C8:0)
notes: FORMULA: C8H15O2 CHARGE: -1
is: HMDB00482
is: SBO:0000247
is: C06423
boundary condition: false

metaR 7DHCHSTEROLtr
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
name: cholesterol precursor intracellular transport
type: Reaction
fast: false
is described by: ECO:0000000

metaM xol7aone r
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01993
constant: false
is: CHEBI:17899
type: Species

metaR RE3421R
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
kinetic law: MODEL1310110010#
name: RE3421
fast: false
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_6bd3ebb9_966b_4af4_a862_64fafe94a1e3
name: SGPP2
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:130367
type: Species
constant: false
is: Q8IWX5
has only substance units: false

metaM tettet6 c
type: Species
name: tetracosatetraenoic acid n-6
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB06246
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_d22ab03a_1861_4ec4_b0fa_5a9fc362acc7
is encoded by: hsa:125965
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: COX6B2
is: Q6YFQ2

metaR M4MPDOL Uter
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110010#
reversible: false
name: m4mpdol flippase

metaR r0973
is described by: ECO:0000000
name: Facilitated diffusion
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_e67ca233_be5c_4d01_a706_58ba88094ee8
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: Q02318
initial amount: NaN
name: CYP27A1
is encoded by: hsa:1593

http://identifiers.org/biomodels.db/MODEL1310110010#_da90ddb0_b273_41f5_8539_557c112e3f1b
is: P15291
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:2683
boundary condition: true
name: B4GALT1
initial amount: NaN
type: Species
is: SBO:0000252

metaM ksii core2 deg1 l
is: SBO:0000247
type: Species
is: CHEBI:57737
initial amount: NaN
is: HMDB00868
name: keratan sulfate II (core 2-linked), degradation product 1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C70H113N5O59S3X CHARGE: -3

metaM hco3 c
initial amount: NaN
is: CHEBI:17544
boundary condition: false
is: HMDB00595
constant: false
is: SBO:0000247
name: Bicarbonate
is: C00288
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaR RE1807C
reversible: true
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1807
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_e3c996e5_f5b0_4023_9504_58519d10d2aa
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ACP6
is: Q9NPH0
is encoded by: hsa:51205
has only substance units: false
initial amount: NaN

metaM h x
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: http://identifiers.org/pubchem.compound/3380
name: proton
is: SBO:0000247
has only substance units: false
is: C00080
boundary condition: false
type: Species
is: CHEBI:24636
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_e8856c4a_579d_4bcf_a3cc_347da73e1a1d
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ALDH3A2
is encoded by: hsa:224
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: P51648

http://identifiers.org/biomodels.db/MODEL1310110010#_6b76cdb3_4356_43ee_a09a_edd60cd7a0ba
is: P09417
constant: false
is encoded by: hsa:5860
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: QDPR
type: Species
initial amount: NaN

metaR 25HVITD3tm
name: 25-hydroxyvitamin D3 transport from mitochondria
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
kinetic law: MODEL1310110010#

metaM ksi pre16 g
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:58053
is: C00130
constant: false
is: HMDB00175
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
name: keratan sulfate I biosynthesis, precursor 16

metaM ksi pre3 g
is: SBO:0000247
notes: FORMULA: C93H152N6O67X CHARGE: -1
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: CHEBI:58053
has only substance units: false
initial amount: NaN
is: C00130
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 3

metaR CO2t
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110010#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
name: CO2 transporter via diffusion
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#

metaR MALSO3tm
is described by: ECO:0000269
type: Reaction
product: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
is: SBO:0000185
name: Malate:sulfite antiport, mitochondrial
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_6ead37a4_9145_4519_b0bd_b876803b93eb
is encoded by: hsa:622
constant: false
name: BDH1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaR r0549
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.6.99.3
is version of: http://identifiers.org/ec-code/1.6.5.3
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/6.1.1.17

metaR GALNTg
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
name: GalNAc transferase, Golgi apparatus
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.41
kinetic law: MODEL1310110010#

metaM dhcholestanate m
is: HMDB00359
is: CHEBI:16577
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

http://identifiers.org/biomodels.db/MODEL1310110010#_bade468a_bd65_47e4_a146_f00426f9082a
constant: false
is: B2RBR4
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6575
is: SBO:0000252
initial amount: NaN
name: SLC20A2
type: Species

metaR ADSL1
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.3.2.2
type: Reaction
is: SBO:0000176
product: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
is described by: ECO:0000269
name: adenylosuccinate lyase

metaR EX c4crn
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaR r0750
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
product: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_e8d8d9ab_7652_48fb_9b8b_be0d6a5a3ee5
initial amount: NaN
is: Q8WUX1
is encoded by: hsa:92745
name: SLC38A5
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_0d82de9f_c663_4e63_ab06_05ce0098ca33
constant: false
initial amount: NaN
name: GALT
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: E7ET32
is encoded by: hsa:2592

http://identifiers.org/biomodels.db/MODEL1310110010#_743540a8_ab78_4000_a431_79bb821b4d41
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: _728637_1_c
boundary condition: true
is encoded by: hsa:728637

metaM 3ohdcoa x
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: CHEBI:57349
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: 3-oxopalmitoyl-CoA(4-)
is: HMDB06402

metaR RE0344C
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
name: RE0344
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
fast: false
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reactant: MODEL1310110010#

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_3af13440_e132_42cc_8fa5_2501fb315e88
boundary condition: true
is encoded by: hsa:51292
name: GMPR2
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q86T14
is: SBO:0000252

metaR 34DHPHEt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
is described by: ECO:0000269
product: MODEL1310110010#
name: 3,4-Dihydroxy-L-phenylalanine transport
fast: false

metaR CERT1gt
modifier: MODEL1310110010#
product: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
name: ceramide transport protein
is: SBO:0000185
type: Reaction
is described by: ECO:0000304

metaM tettet6 e
name: tetracosatetraenoic acid n-6
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB06246
has only substance units: false
constant: false
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
type: Species

metaM mag hs e
is: SBO:0000247
initial amount: NaN
name: monoacylglycerol 2
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
constant: false
is: HMDB03073
type: Species
is: CHEBI:32391
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM 5pmev x
has only substance units: false
is: CHEBI:58146
type: Species
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
initial amount: NaN
boundary condition: false
is: HMDB01343
initial concentration: 1.0
constant: false
name: (R)-5-phosphonatomevalonate(3-)
is: SBO:0000247

metaR ACACT1x
name: acetyl-CoA C-acetyltransferase, mitochondrial
modifier: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110010#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110010#_88528daa_2c7f_4ea2_b564_b1c14d2d9c64
constant: false
initial concentration: NaN
is: Q8WWX8
initial amount: NaN
name: SLC5A11
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:115584
has only substance units: false

metaR RE0830N
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
reactant: MODEL1310110010#
name: RE0830
fast: false
is: SBO:0000176
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_ec4fe5b7_01d2_4cb9_896b_2bb6ea5b61a9
is encoded by: hsa:10246
initial concentration: NaN
is: O00624
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: SLC17A2
type: Species

metaR GLUTCOADHm
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.99.7
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
is described by: ECO:0000304
name: glutaryl-CoA dehydrogenase (mitochondria)
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
reversible: false
fast: false

metaM tyr L e
has only substance units: false
boundary condition: false
constant: false
is: HMDB00158
is: CHEBI:17895
initial concentration: 1.0
name: L-tyrosine
is: SBO:0000247
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_8c2998bf_e7a2_459a_b3ae_5a2350a300a5
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:218
type: Species
is: P30838
constant: false
boundary condition: true
name: ALDH3A1

metaM duri e
constant: false
name: Deoxyuridine
initial concentration: 1.0
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false
initial amount: NaN
is: C00526
is: SBO:0000247
type: Species
is: CHEBI:16450
is: HMDB00012
boundary condition: false

metaM dhcholestanate x
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00359
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577

http://identifiers.org/biomodels.db/MODEL1310110010#_7b73253e_5644_4aa3_89b7_2856bc2ab19e
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: Q8N1Q1
initial concentration: NaN
name: CA13
is encoded by: hsa:377677
is: SBO:0000252

metaM crm hs c
name: N-acylsphingosine
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:52639
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species

metaM bilirub e
is: HMDB00054
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57977
type: Species

metaR SERtN1
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
product: MODEL1310110010#
name: Serine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
reversible: true
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110010#_4c5da61e_c00a_442d_b7f6_e9f314178d50
is encoded by: hsa:10195
is: SBO:0000252
constant: false
name: ALG3
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaM ptth c
name: pantetheine
is: SBO:0000247
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial amount: NaN
type: Species
boundary condition: false
is: HMDB03426
is: CHEBI:16753
initial concentration: 1.0
has only substance units: false
constant: false

metaM Ser Thr g
has only substance units: false
boundary condition: false
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
is: CHEBI:58336
is: SBO:0000247
is: HMDB00645
type: Species
constant: false
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0

metaM 4mlacac c
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB02052
is: CHEBI:17105
is: SBO:0000247
name: 4-maleylacetoacetate
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036

metaR THRGLNexR
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
name: L-threonine/glycine reversible exchange
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
fast: false

metaR GALASE17ly
is: SBO:0000176
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR RIBt
is: SBO:0000185
name: ribose transport via diffusion
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reversible: true
product: MODEL1310110010#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

metaR r1669
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_7cc2a942_3057_4252_8c1f_bfdfa4c0ff44
is: SBO:0000252
name: ALG8
initial concentration: NaN
is encoded by: hsa:79053
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

metaR r1643
reversible: true
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_8b94a46c_3211_41ce_8b76_e7cc86ec5ce1
is encoded by: hsa:1103
name: CHAT
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: Q6LEN5
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_1c296150_1d94_429b_84eb_7e08b951e424
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: MVD
has only substance units: false
is encoded by: hsa:4597
is: P53602
initial concentration: NaN
boundary condition: true

metaM dcamp c
is: SBO:0000247
name: N6-(1,2-Dicarboxyethyl)-AMP
boundary condition: false
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00536
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: CHEBI:57567
is: C03794

metaM ksii core4 deg2 l
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
name: keratan sulfate II (core 4-linked), degradation product 2
is: CHEBI:12936
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00143
type: Species

metaR AMETr
fast: false
reversible: true
name: S-Adenosyl-L-methionine intracellular diffusion
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction

metaM m2mpdol U c
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
is: CHEBI:28049
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species

metaM ksi deg9 l
is: HMDB00143
is: SBO:0000247
constant: false
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
type: Species
name: keratan sulfate I, degradation product 9
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:12936

metaR DOLPMT4 Uer
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000185
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
fast: false

metaM ctp e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
constant: false
name: CTP(4-)
is: CHEBI:37563
boundary condition: false
is: HMDB00082
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_09b06c93_c760_4c2c_b7f2_8023b4285fa3
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: SLC22A2
is: SBO:0000252
is encoded by: hsa:6582
initial concentration: NaN

metaM ile L m
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: CHEBI:17191
is: HMDB00172
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: L-isoleucine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_6d5b5efa_6dc4_4197_9883_642e3b4e45f1
constant: false
type: Species
is encoded by: hsa:9060
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: O95340
name: PAPSS2
has only substance units: false
initial amount: NaN

metaR CYTD
is: SBO:0000176
is described by: ECO:0000254
reactant: MODEL1310110010#
type: Reaction
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
name: cytidine deaminase
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.5.4.5

metaR ARACHt
reactant: MODEL1310110010#
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110010#
fast: false
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_f88dc208_d3d8_4b34_a81b_a61751db92c8
is encoded by: hsa:29929
has only substance units: false
boundary condition: true
is: SBO:0000252
name: ALG6
type: Species
is: Q9Y672
constant: false
initial amount: NaN
initial concentration: NaN

metaM CE2421 m
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
type: Species
boundary condition: false
is: CHEBI:30623
constant: false
is: SBO:0000247
name: (3S)-3-hydroxylinoleoyl-CoA
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02329

MODEL1310110010#
species: metaM hdcea c
species: metaM C05957 r
species: metaM urcan c
species: metaM ksi deg29 l
species: metaM retfa c
species: metaM gly e
species: metaM retinol cis 11 e
species: metaM odecoa m
species: metaM dhcrm hs c
species: metaM chol r
species: metaM HC02175 c
species: metaM C05965 e
species: metaM h2o m
type: KineticLaw
species: metaM gbside hs g
species: metaM ksi pre16 g
species: metaM HC01104 e
species: metaM ksi pre9 g
species: metaM core3 g
species: metaM apoC Lys m
species: metaM CE1926 e
species: metaM gdpfuc c
species: metaM tdcoa c
species: metaM gmp g
species: metaM HC01118 r
species: metaM met L e
species: metaM guln c
species: metaM core2 g
species: metaM HC01401 x
species: metaM h2o2 e
species: metaM dolmanp U r
species: metaM ade c
species: metaM duri n
species: metaM ppi c
species: metaM malthp e
species: metaM CE4795 x
species: metaM HC02187 c
species: metaM glc D c
species: metaM cl c
stoichiometry: 0.005829
species: metaM 3mob c
species: metaM HC02202 e
species: metaM HC01415 m
species: metaM btcoa c
species: metaM pi x
species: metaM mmcoa R m
species: metaM fe3 e
stoichiometry: 0.02
species: metaM octa c
species: metaM for c
type: ModifierSpeciesReference
species: metaM nrpphrsf e
species: metaM 5adtststerones c
species: metaM ksii core4 pre8 g
stoichiometry: 0.126406
species: metaM ksi pre7 g
stoichiometry: 0.259466
species: metaM amp e
species: metaM ksi pre15 g
species: metaM dadp n
species: metaM pnto R c
species: metaM 3hpp m
species: metaM HC01223 m
species: metaM gmp c
species: metaM pnto R e
species: metaM 4hoxpacd c
species: metaM ksi pre20 g
species: metaM adrncoa c
stoichiometry: 0.009442
species: metaM ha l
species: metaM gdp g
species: metaM ppi x
species: metaM fmn e
species: metaM ksii core2 pre4 g
species: metaM ksii core4 pre3 g
species: metaM dgchol e
species: metaM etha c
species: metaM dpcoa e
species: metaM n5m2masn g
species: metaM dc2coa m

metaM gdpmann c
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: GDP-alpha-D-mannose(2-)
is: HMDB01163
is: CHEBI:57527
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR ALAtN1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
is described by: ECO:0000269
reactant: MODEL1310110010#
name: Alanine transport (Na, H coupled)
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#

metaR L LACt4r
reactant: MODEL1310110010#
name: L-lactate reversible transport via sodium symport
reversible: true
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
kinetic law: MODEL1310110010#

metaR r1668
reversible: true
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#

metaM udpgal g
is: CHEBI:58439
initial concentration: 1.0
constant: false
is: HMDB00302
type: Species
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
name: UDP-D-galactose(2-)
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_a41be88e_7176_4035_8c24_1813772466e9
has only substance units: false
type: Species
name: ACO1
initial concentration: NaN
is encoded by: hsa:48
is: SBO:0000252
boundary condition: true
constant: false
is: P21399
initial amount: NaN

metaR r1642
is: SBO:0000185
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
product: MODEL1310110010#
modifier: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_8aa3bd4f_48f7_4abe_bd23_949697d07acf
constant: false
is: Q9BY07
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: SLC4A5
is encoded by: hsa:57835

metaM duri c
name: Deoxyuridine
initial concentration: 1.0
boundary condition: false
type: Species
is: C00526
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
is: CHEBI:16450

metaM acgam c
is: CHEBI:17411
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
is: HMDB00215
type: Species
constant: false
name: N-acetyl-D-glucosamine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM pac c
constant: false
is: SBO:0000247
name: phenylacetate
boundary condition: false
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial amount: NaN
is: HMDB00209
initial concentration: 1.0
has only substance units: false
is: CHEBI:18401
type: Species

metaM tyr L c
initial amount: NaN
boundary condition: false
name: L-tyrosine
initial concentration: 1.0
constant: false
is: CHEBI:17895
is: HMDB00158
is: SBO:0000247
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
has only substance units: false

metaM lthstrl r
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: 5alpha-cholest-7-en-3beta-ol
is: HMDB01170
type: Species
is: CHEBI:17168
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
has only substance units: false

metaM dhf e
initial amount: NaN
name: dihydrofolate(2-)
constant: false
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: CHEBI:57451
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB01056

metaM bilirub c
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00054
name: bilirubin(2-)
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM crm hs e
initial amount: NaN
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:52639
has only substance units: false
boundary condition: false
constant: false

metaR r1667
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
is: SBO:0000185
reversible: true
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_2bb3a1fb_9c84_41b8_a59c_75cc2861694e
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:8704
is: SBO:0000252
initial amount: NaN
name: B4GALT2
initial concentration: NaN

metaM pser L c
is: SBO:0000247
is: CHEBI:15811
type: Species
is: HMDB01721
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
name: O-Phospho-L-serine
initial concentration: 1.0
boundary condition: false

metaR RE1531M
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
kinetic law: MODEL1310110010#
name: RE1531
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction

metaM gthrd m
name: glutathionate(1-)
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57925
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: HMDB00125
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_409327de_b85a_4ade_afff_993dbbc9e01f
initial concentration: NaN
has only substance units: false
name: VNN2
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:8875
is: O95498

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR r1645
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
reactant: MODEL1310110010#
modifier: MODEL1310110010#

metaM n2m2nm l
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: n2m2nmasn (w/o peptide linkage)
is: CHEBI:57312
has only substance units: false
notes: FORMULA: C58H97N5O41 CHARGE: 0
is: HMDB01356
is: SBO:0000247

metaM HC01712 m
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
is: CHEBI:28391
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
name: S-Glutaryldihydrolipoamide
has only substance units: false

metaM m1mpdol U c
type: Species
is: CHEBI:28067
constant: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_41ecfa5b_0b30_4b75_b896_a37c08a7ef4b
constant: false
is encoded by: hsa:4833
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: O00746
name: NME4

metaR RE0830C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#
name: RE0830
product: MODEL1310110010#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_379d7fc6_47c1_4082_a3b1_ba36cc20b56d
name: _AF080579_1_c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:AF080579
constant: false

metaM 3php c
is: HMDB01024
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 3-phosphonatooxypyruvate(3-)
type: Species
initial amount: NaN
is: CHEBI:18110
has only substance units: false
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232

metaR ADKd
is: SBO:0000176
name: adenylate kinase (d form)
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
type: Reaction
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
fast: false
reversible: true
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110010#

metaR H2Otp
reactant: MODEL1310110010#
name: H2O transport, peroxisomal
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_c33f9f28_1a0b_4366_b291_456f0f3f6276
initial concentration: NaN
is: Q0VAA5
name: PLCXD2
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:257068
constant: false
type: Species

metaM ctp c
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: C00063
initial amount: NaN
is: SBO:0000247
name: CTP
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082

http://identifiers.org/biomodels.db/MODEL1310110010#_238fbfcb_8365_4331_a11f_12decacc723a
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: GSTZ1
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2954

metaR DCMPDA
is version of: http://identifiers.org/ec-code/3.5.4.12
is: SBO:0000176
type: Reaction
fast: false
reversible: true
product: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
reactant: MODEL1310110010#
name: dCMP deaminase

metaR r1666
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110010#
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM 3ohdcoa m
type: Species
is: CHEBI:57349
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: 3-oxopalmitoyl-CoA(4-)
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: HMDB06402
boundary condition: false

metaM dhcrm hs c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: dihydroceramide
initial amount: NaN
is: CHEBI:31488
type: Species
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126

metaR r1644
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110010#
fast: false
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110010#
is: SBO:0000185
modifier: MODEL1310110010#

metaR GALASE19ly
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110010#_2da9b65d_86e1_423f_a596_bbadae88adea
initial concentration: NaN
is: Q9BWD1
type: Species
constant: false
name: ACAT2
is encoded by: hsa:39
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaR RDH4
fast: false
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:9115228 NOTES:IT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.315
type: Reaction
modifier: MODEL1310110010#
name: retinol dehydrogenase (13-cis,NADH)
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR AG13T13g
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM dhf c
is: CHEBI:57451
type: Species
initial amount: NaN
is: SBO:0000247
is: C00415
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
name: 7,8-Dihydrofolate
has only substance units: false
initial concentration: 1.0
is: HMDB01056

metaM thym c
name: Thymine
is: SBO:0000247
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: C00178
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:17821
is: HMDB00262
boundary condition: false

metaR HSD17B4x
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
name: hydroxysteroid (17-beta) dehydrogenase 4
fast: false
is described by: ECO:0000269
modifier: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR r2518
is: SBO:0000185
reversible: true
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
type: Reaction
fast: false

metaM l2n2m2mn l
initial concentration: 1.0
is: CHEBI:12936
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
boundary condition: false
is: HMDB00143
has only substance units: false
is: SBO:0000247
notes: FORMULA: C54H91N3O41 CHARGE: 0
initial amount: NaN
type: Species
constant: false

metaM udpgal c
type: Species
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00302
has only substance units: false
is: CHEBI:58439
name: UDP-D-galactose(2-)

metaR RE1807M
is: SBO:0000176
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
modifier: MODEL1310110010#
name: RE1807
product: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15

http://identifiers.org/biomodels.db/MODEL1310110010#_83df6de9_65c0_4b38_bc21_22d3fb9882e3
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:65010
is: Q9NQU1
initial amount: NaN
name: SLC26A6
has only substance units: false
is: SBO:0000252
constant: false

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR r1665
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
name: Y+LAT2 Utilized transport
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_c5c5da16_89b1_4c8f_b642_0d782fd21a60
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4694
name: NDUFA1
is: Q6IBB5

metaM ksi pre23 g
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:28067
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 23

metaM ala B c
boundary condition: false
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
is: CHEBI:16958
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

metaM Ser Thr l
has only substance units: false
is: SBO:0000247
name: protein-linked serine or threonine residue (O-glycosylation site)
is: CHEBI:58190
initial concentration: 1.0
is: HMDB00224
initial amount: NaN
constant: false
notes: FORMULA: XH CHARGE: 0
type: Species
boundary condition: false

metaR KCC2t
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110010#
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
type: Reaction
name: K+-Cl- cotransporter (NH4+)
reversible: true

metaR GALU
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
reactant: MODEL1310110010#
name: UTP-glucose-1-phosphate uridylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.9
type: Reaction
product: MODEL1310110010#
is described by: ECO:0000134
reversible: true

metaR r2517
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
reactant: MODEL1310110010#
reversible: true
product: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110010#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:

metaR r0287
modifier: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR S6T2g
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_033a62dd_f5df_4a78_9aff_1bb18e538c5e
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ATP10A
is encoded by: hsa:57194
has only substance units: false
is: O60312

metaR r1590
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110010#
reversible: true
is described by: ECO:0000000

metaM m3mpdol U c
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
is: SBO:0000247
has only substance units: false
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:37632
initial concentration: 1.0
type: Species

metaR INSt
reactant: MODEL1310110010#
name: Inosine transport (diffusion)
modifier: MODEL1310110010#
reversible: true
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_20b6869e_bb8d_401f_a8b3_53a52c73619e
has only substance units: false
constant: false
is: P32322
initial amount: NaN
is encoded by: hsa:5831
is: SBO:0000252
initial concentration: NaN
type: Species
name: PYCR1
boundary condition: true

metaR GALASE10ly
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_6bf07714_1b86_497e_bc5e_b915bc790920
name: CA8
has only substance units: false
is: P35219
constant: false
is encoded by: hsa:767
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaR GLNtN1
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
modifier: MODEL1310110010#
type: Reaction
name: Glutamine transport (Na, H coupled)
reactant: MODEL1310110010#
fast: false
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110010#

metaR r0208
type: Reaction
is version of: http://identifiers.org/ec-code/4.4.1.1
is described by: ECO:0000000
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
is: SBO:0000176
modifier: MODEL1310110010#
fast: false
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:

metaR RE1342C
is: SBO:0000176
fast: false
name: RE1342
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
reversible: true
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_edd11d2e_08c1_4d27_8db1_0d66c24c247f
type: Species
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is: P22413
is encoded by: hsa:5167
initial amount: NaN
name: ENPP1
initial concentration: NaN

metaR URAt
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: true
product: MODEL1310110010#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
modifier: MODEL1310110010#
name: uracil transport via facilated diffusion
reactant: MODEL1310110010#

metaR DOLASNT Uer
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
reactant: MODEL1310110010#
type: Reaction
reversible: false
modifier: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.119

http://identifiers.org/biomodels.db/MODEL1310110010#_be90dd40_385b_45e2_8b18_2c3cd4349b3c
type: Species
is: Q6P9G0
boundary condition: true
constant: false
has only substance units: false
name: CYB5D1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:124637

metaR RDH2
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.315
modifier: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
is: SBO:0000176
is described by: ECO:0000269
reversible: true
name: retinol dehydrogenase (9-cis,NADH)

metaM cholcoads x
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
boundary condition: false
is: CHEBI:27505
is: SBO:0000247
is: HMDB06889
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
constant: false

metaM ksii core4 pre8 g
initial amount: NaN
notes: FORMULA: C83H134N7O61SX CHARGE: -2
has only substance units: false
is: CHEBI:58053
is: C00130
type: Species
name: keratan sulfate II biosynthesis, precursor 8
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00175
boundary condition: false

metaM 3hbcoa m
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
boundary condition: false
constant: false
is: CHEBI:57316
initial amount: NaN
is: HMDB01166
name: (S)-3-hydroxybutanoyl-CoA(4-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_0ff73f80_a3d4_420c_954f_263d1225d25b
name: ST3GAL3
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:6487

http://identifiers.org/biomodels.db/MODEL1310110010#_ea8acd33_038f_444d_85ed_b15c0af55d38
name: NDUFA12
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:55967
is: F8VQS7

metaM udpgal e
name: UDP-D-galactose(2-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
is: CHEBI:58439
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species

metaM ficytC m
is: SBO:0000247
constant: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15991
boundary condition: false
has only substance units: false
type: Species
name: Ferricytochrome c

metaR SPHS1Ptr
product: MODEL1310110010#
fast: false
name: sphingosine-1-phosphate transport
type: Reaction
reversible: true
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_6a1bdd6d_ebca_403c_b40d_81645b68717d
is encoded by: hsa:56301
type: Species
name: SLC7A10
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: Q9NS82
boundary condition: true

metaM 13dampp c
initial amount: NaN
is: SBO:0000247
is: CHEBI:57484
boundary condition: false
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
type: Species
initial concentration: 1.0
name: trimethylenediaminium
is: HMDB00002
constant: false
has only substance units: false

metaR r1591
type: Reaction
kinetic law: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
reversible: true

metaM CE2417 m
is: CHEBI:28387
constant: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: HMDB11123
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_08542ecc_f0da_4606_9192_d0321be95891
is encoded by: hsa:6817
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: SULT1A1
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_e125267b_7bb1_449f_b40e_232816ea8793
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110010#_7f76f9c3_9319_4876_bb04_e6d01e9213ff
boundary condition: true
name: _642502_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:642502
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaR 10FTHFtm
kinetic law: MODEL1310110010#
is described by: ECO:0000000
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_4a5d129a_3e4c_4204_9ce8_f2fdd6a6d161
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: Q13825
is encoded by: hsa:549
is: SBO:0000252
boundary condition: true
name: AUH

metaR r1641
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
reversible: true

metaM CE5118 m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
is: CHEBI:12947
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_a91b4174_afe5_4891_9ca8_39751b995fd0
boundary condition: true
is encoded by: hsa:9963
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: SLC23A1
initial concentration: NaN

metaR RDH1
is version of: http://identifiers.org/ec-code/1.1.1.315
modifier: MODEL1310110010#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
kinetic law: MODEL1310110010#
type: Reaction
fast: false
reactant: MODEL1310110010#
is: SBO:0000176
reversible: true
product: MODEL1310110010#
name: retinol dehydrogenase (all-trans)

metaM ala B e
boundary condition: false
is: HMDB00056
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
is: CHEBI:16958
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR G3PD2m
fast: false
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
modifier: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.5.3
kinetic law: MODEL1310110010#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2820.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.99.5 Confidence Level: 2 AUTHORS: PMID:11385633,PMID:8549872 NOTES:replaces old version which contains redundant metabolite (gly3p) NCD split compartmentation NJ
reversible: false

metaR STCOAtx
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
name: fatty acid intracellular transport
reactant: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR r1662
reactant: MODEL1310110010#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
modifier: MODEL1310110010#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_8f8338fe_7662_4d27_81e5_b9fe33fe5bee
name: PRDX2
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:7001
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM h r
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:24636
is: C00080
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_9b5ca4c0_5557_4204_bef3_5c633145846b
type: Species
is encoded by: hsa:8854
initial concentration: NaN
constant: false
initial amount: NaN
is: F5H2Y9
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ALDH1A2

metaR r1640
modifier: MODEL1310110010#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR PCt
name: phosphatidylcholine transporter
is: SBO:0000185
fast: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
is described by: ECO:0000269
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.6.3.44

http://identifiers.org/biomodels.db/MODEL1310110010#_8792d1fc_9b2c_4a78_a13c_0f16b860de8f
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: SULT1A1
is encoded by: hsa:6817
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_8342a693_d7d4_477e_af5c_9e18efb0e58b
is encoded by: hsa:8534
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: CHST1
is: O43916

metaR r2519
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_c38c97f9_c1c7_40d3_8bf8_f13fc264fcf8
initial amount: NaN
is encoded by: hsa:5162
initial concentration: NaN
name: PDHB
has only substance units: false
type: Species
constant: false
is: P11177
is: SBO:0000252
boundary condition: true

metaR r1592
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110010#
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_a09c1665_239c_4788_84ff_18ec4f7f6685
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O14772
constant: false
is encoded by: hsa:8790
name: FPGT
initial amount: NaN
is: SBO:0000252

metaM oaa c
is: SBO:0000247
constant: false
is: C00036
type: Species
is: HMDB00223
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:3338
notes: FORMULA: C4H2O5 CHARGE: -2
name: Oxaloacetate

metaR CMPACNAtg
reversible: true
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
name: CMP-Sia Golgi transport via CMP antiport
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110010#_f57732a7_9bf9_46db_8f79_48ed813896e7
constant: false
type: Species
is encoded by: hsa:160287
name: LDHAL6A
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q6ZMR3
is: SBO:0000252
has only substance units: false

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaM ksi deg17 l
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:12936
name: keratan sulfate I, degradation product 17
has only substance units: false
is: HMDB00143
initial concentration: 1.0
constant: false
type: Species

metaR NAIt
name: Na+ / iodide cotransport
modifier: MODEL1310110010#
is described by: ECO:0000269
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false

metaR FUCtly
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000185
reversible: false
product: MODEL1310110010#
fast: false
name: L-fucose efflux from lysosome

http://identifiers.org/biomodels.db/MODEL1310110010#_644a251a_778a_48e2_8202_7d7feb31de29
name: GLUD2
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:2747
is: P49448

metaM hom L c
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: CHEBI:15699
initial concentration: 1.0
is: HMDB00719
is: SBO:0000247
name: L-homoserine
type: Species

metaR r0618
fast: false
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_49a75394_0d78_4207_863e_975e4bc2ce50
constant: false
is encoded by: hsa:6576
has only substance units: false
initial concentration: NaN
name: SLC25A1
is: SBO:0000252
is: D9HTE9
initial amount: NaN
boundary condition: true
type: Species

metaM leu L m
boundary condition: false
name: L-leucine
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
has only substance units: false
type: Species
is: CHEBI:15603
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM h2o r
type: Species
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:15377
is: HMDB02111
name: H2O
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00001

http://identifiers.org/biomodels.db/MODEL1310110010#_e9561884_50c8_4da0_ae0d_7647bff97397
type: Species
is: SBO:0000252
constant: false
is: P47895
name: ALDH1A3
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:220
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_10e1a967_21aa_4bfd_b554_d500df02419e
initial concentration: NaN
has only substance units: false
is: Q9BXS1
constant: false
type: Species
is: SBO:0000252
name: IDI2
initial amount: NaN
boundary condition: true
is encoded by: hsa:91734

metaM lnlncg r
boundary condition: false
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial concentration: 1.0
type: Species
name: gamma-linolenate
is: CHEBI:32391
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_a19d34ca_209c_40f5_ac6f_34786920e927
is encoded by: hsa:1120
constant: false
is: SBO:0000252
is: A0PJM6
initial concentration: NaN
initial amount: NaN
type: Species
name: CHKB
boundary condition: true
has only substance units: false

metaM CE5121 m
boundary condition: false
initial concentration: 1.0
is: CHEBI:57449
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: trans-3-decenoyl-CoA

metaR r0295
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000176
name: glycine synthase Nitrogen metabolism EC:2.1.2.10

metaR ACOX22x
fast: false
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.99.3
name: acyl-Coenzyme A oxidase 2, branched chain
is: SBO:0000176
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ

http://identifiers.org/biomodels.db/MODEL1310110010#_dec7abde_4152_44c1_ae54_fee6aef4d660
boundary condition: true
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: Q14542
initial concentration: NaN
is encoded by: hsa:3177
name: SLC29A2

metaR TETTET6t
is described by: ECO:0000000
fast: false
name: fatty acid transport via diffusion
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
kinetic law: MODEL1310110010#
is: SBO:0000185
type: Reaction

metaM HC01397 m
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: SBO:0000247
name: (S)-3-Hydroxyhexadecanoyl-CoA
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27402
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_81df92e0_1c41_4282_9dae_5ed63cd7d0bc
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:137872
initial concentration: NaN
is: Q8IWW8
has only substance units: false
name: ADHFE1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_432de859_f43d_4877_82f1_f2abe41c3136
initial amount: NaN
name: GGT7
is encoded by: hsa:2686
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is: A0PJJ9

metaM 3hibutcoa m
is: CHEBI:28259
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: (S)-3-Hydroxyisobutyryl-CoA
is: HMDB01052
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_fb28762b_87b1_408c_b62f_55f5a59739e1
is: P00414
is encoded by: hsa:4514
initial concentration: NaN
name: COX3
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false

metaM strdnccoa m
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
boundary condition: false
name: stearidonyl coenzyme A
is: C16163
is: HMDB06519
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/47205473
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_4e4699b5_9b8e_45ab_99f8_8272ec458083
type: Species
boundary condition: true
has only substance units: false
name: RRM2B
initial amount: NaN
initial concentration: NaN
constant: false
is: Q7LG56
is encoded by: hsa:50484
is: SBO:0000252

metaR RTOTALt
reversible: true
kinetic law: MODEL1310110010#
name: RTOTAL transport
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_d9933f44_5672_4e53_80ac_2b3964846666
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:4513
name: COX2
is: Q7GXZ8
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_bef5504f_cde1_4942_9e38_94fea221db0e
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:6487
boundary condition: true
type: Species
name: ST3GAL3
is: SBO:0000252

metaM no e
name: Nitric oxide
is: SBO:0000247
is: C00533
boundary condition: false
is: CHEBI:16480
has only substance units: false
is: HMDB03378
initial amount: NaN
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_35884a17_0ce1_48f3_8653_22e29f49edb6
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: B4DUG1
has only substance units: false
constant: false
name: SLC24A1
is encoded by: hsa:9187
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_62ae5851_fbc6_439e_87ab_85cfb94ed790
boundary condition: true
name: PANK2
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:80025
initial amount: NaN
has only substance units: false

metaR RE0453C
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110010#
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110010#
name: RE0453
type: Reaction
is described by: ECO:0000000

metaR r1581
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#

metaM 4hphac c
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: CHEBI:48999
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00020
name: 4-hydroxyphenylacetate
boundary condition: false
type: Species

metaR GLNLASEer
fast: false
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
name: gluconolactonase, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110010#

metaR r2514
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
reversible: true
name: Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110010#
type: Reaction

metaR IZPN
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is: SBO:0000176
name: Imidazolonepropionase
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM fol c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00121
type: Species
is: SBO:0000247
notes: FORMULA: C19H18N7O6 CHARGE: -1
constant: false
name: Folate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_991cba10_c773_4ac4_a3aa_ca83a5c220f0
boundary condition: true
initial concentration: NaN
is: Q9NY65
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:1962
name: EHHADH
is: SBO:0000252
constant: false

metaR r0202
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reversible: true
type: Reaction
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR ASCBOX
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
name: ascorbic acid oxidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110010#
is: SBO:0000176
reversible: false
fast: false

metaR CERT2gt
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein
is: SBO:0000185
modifier: MODEL1310110010#
fast: false
product: MODEL1310110010#

metaM ibcoa m
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
has only substance units: false
name: isobutyryl-CoA(4-)
initial concentration: 1.0
is: CHEBI:57338
is: HMDB01243
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_b9a60d0b_9548_474c_8189_4bc45165ab65
is: P04066
is encoded by: hsa:2517
name: FUCA1
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_a91cf99c_47be_462c_beae_badf197ddd7a
initial concentration: NaN
is: O43252
constant: false
type: Species
name: PAPSS1
has only substance units: false
is encoded by: hsa:9061
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR RE2626C
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110010#
name: RE2626
fast: false
is: SBO:0000176
type: Reaction

metaR 3AIB Dtm
name: transport of 3aib_D into mitochondria
is described by: ECO:0000134
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
type: Reaction

metaR MHISOR
reactant: MODEL1310110010#
is described by: ECO:0000269
fast: false
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)
reversible: false
kinetic law: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.21
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.4.3.22
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:

metaM hom L e
initial concentration: 1.0
initial amount: NaN
is: HMDB00719
type: Species
name: L-homoserine
is: CHEBI:15699
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247

metaR r1584
product: MODEL1310110010#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110010#

metaM CE1617 r
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
boundary condition: false
is: CHEBI:17898
type: Species
is: HMDB01358
name: 9-cis-retinoate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_e98bc249_d2d3_4b99_9af0_7dc3d6df24ef
is: SBO:0000252
initial concentration: NaN
is: P22352
boundary condition: true
type: Species
is encoded by: hsa:2878
has only substance units: false
name: GPX3
constant: false
initial amount: NaN

metaM carn c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00033
boundary condition: false
notes: FORMULA: C9H14N4O3 CHARGE: 0 INCHI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
is: CHEBI:15727
name: carnosine
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_99361cd5_8e8e_4949_babb_4533b8854ba9
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:3034
boundary condition: true
name: HAL
initial concentration: NaN
is: B4E0V8
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_dbaceed0_c2dc_4894_b0d6_51d6fa4bb47e
boundary condition: true
name: _AA854479_1_m
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA854479
has only substance units: false
constant: false
initial concentration: NaN

metaR AHC
is version of: http://identifiers.org/ec-code/3.3.1.1
reactant: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
type: Reaction
name: adenosylhomocysteinase
is: SBO:0000176
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
kinetic law: MODEL1310110010#
fast: false
reversible: true

metaR r0698
product: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
is: SBO:0000176
fast: false
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
kinetic law: MODEL1310110010#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.27
type: Reaction

metaR FACOAL260
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
name: fatty-acid--CoA ligase (n-C26:0)
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ
type: Reaction

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_cc4db80c_abb7_45e8_b6de_45e73c29f1b8
is encoded by: hsa:83884
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: Q9BXI2
name: SLC25A2
initial amount: NaN
constant: false

metaR SPHS1Pte
is: SBO:0000185
product: MODEL1310110010#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: sphingosine-1-phosphate transport

metaM 34dhmald c
is: C05577
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7903
is: HMDB06242
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
boundary condition: false
name: 3,4-Dihydroxymandelaldehyde

http://identifiers.org/biomodels.db/MODEL1310110010#_b16d7514_07cd_4cab_9907_144b98516f8f
type: Species
constant: false
is encoded by: hsa:122622
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ADSSL1
is: Q8N142

http://identifiers.org/biomodels.db/MODEL1310110010#_67647c2e_d45f_4d25_91d7_85f97fb93041
initial concentration: NaN
name: ETNK2
is encoded by: hsa:55224
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: Q9NVF9
is: SBO:0000252
boundary condition: true

metaM ptth m
initial amount: NaN
constant: false
name: pantetheine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB03426
boundary condition: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
type: Species
is: CHEBI:16753

metaR r1583
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_5800ca74_3a1a_4e74_98e3_9e6211bce87b
has part: P23921
boundary condition: true
has part: P31350
name: RRM1:RRM2
is: SBO:0000297
type: Species
has only substance units: false
is encoded by: hsa:6241
initial concentration: NaN
constant: false
is encoded by: hsa:6240
initial amount: NaN

metaR AG13T14g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110010#_d9d1289a_8183_4869_a9c4_2326ea158a5b
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: FTCD
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:10841

metaM 4hphac e
initial amount: NaN
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: CHEBI:48999
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00020
name: 4-hydroxyphenylacetate
type: Species
boundary condition: false

metaR r1646
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM h2o n
is: SBO:0000247
is: CHEBI:15377
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
name: water
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species

metaM asn L c
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: SBO:0000247
is: CHEBI:17196
constant: false
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: HMDB00168
name: L-asparagine
initial concentration: 1.0

metaR r1586
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110010#_6d38668f_aaef_4d62_84e2_61f5e0f3b45c
is: P31040
name: SDHA
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:6389

http://identifiers.org/biomodels.db/MODEL1310110010#_ac166c1d_3945_4e4b_9d9e_6d893b001faf
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O95258
is encoded by: hsa:9016
boundary condition: true
initial concentration: NaN
name: SLC25A14
type: Species

metaM dhcholoylcoa x
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
initial concentration: 1.0
is: HMDB06895
boundary condition: false
is: CHEBI:27393
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
initial amount: NaN
type: Species

metaM g1p e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: alpha-D-glucose 1-phosphate(2-)
type: Species
constant: false
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: CHEBI:58601
boundary condition: false
is: HMDB01586

metaR r0860
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.1.2.27
name: Utilized transport
modifier: MODEL1310110010#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185

metaR r0614
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
fast: false
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176

metaR DRPA
is: SBO:0000176
name: deoxyribose-phosphate aldolase
reactant: MODEL1310110010#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110010#
reversible: false
product: MODEL1310110010#
is described by: ECO:0000000

metaM dcholcoa x
type: Species
is: CHEBI:28701
has only substance units: false
is: HMDB06292
boundary condition: false
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a

metaM fadh2 x
is: HMDB01197
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
name: FADH2(2-)
boundary condition: false
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
constant: false
has only substance units: false

metaR BTND1n
product: MODEL1310110010#
name: biotinidase (biotin), nuclear
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
type: Reaction
fast: false
modifier: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.5.1.12

metaR BILIRUBt2
is: SBO:0000185
kinetic law: MODEL1310110010#
is described by: ECO:0000269
product: MODEL1310110010#
type: Reaction
name: bilirubin transport via bicarbonate countertransport
modifier: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
fast: false

metaR r1647
reactant: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
fast: false
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR PTCRTD
name: diffusion of putriscine into the endothelial cells
fast: false
kinetic law: MODEL1310110010#
reversible: true
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
is: SBO:0000185

metaR PRPNCOAHYDm
modifier: MODEL1310110010#
reversible: false
kinetic law: MODEL1310110010#
name: Propenoyl-CoA hydrolase (m)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110010#
fast: false
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110010#

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM sgalside hs l
type: Species
has only substance units: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: sulfatide galactocerebroside
is: CHEBI:16349
is: HMDB00904
constant: false

metaR S6T14g
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110010#
reversible: false
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR r0354
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110010#
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110010#

metaR r2510
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
reactant: MODEL1310110010#
name: Utilized transport
is: SBO:0000185
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_a84a9172_5f8b_47dc_8aa4_ac5fab26fdcd
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ADH4
initial amount: NaN
is encoded by: hsa:127
is: P08319
initial concentration: NaN
constant: false

metaR r1585
reversible: true
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_673ca634_6ce7_4194_894d_7a6f4526b51f
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: NDUFA3
is: SBO:0000252
is encoded by: hsa:4696
is: O95167
constant: false

metaR URCN
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.49
fast: false
name: URCN
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_feb39c1b_a050_4af4_b3d2_ae7d90c344bd
is: P15328
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
name: FOLR1
is: SBO:0000252
is encoded by: hsa:2348

metaR NAGLCAly
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110010#
name: N-acetylglucosaminidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_b17daef6_71f2_46a4_9f0d_457dcd9d9a27
is: SBO:0000252
is encoded by: hsa:AA203143
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: _AA203143_1_c
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_749ae997_d87c_46d7_8947_768553251ba8
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:205
name: AK4
is: SBO:0000252

metaM g1p c
initial concentration: 1.0
is: HMDB01586
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
constant: false
is: C00103
is: CHEBI:58601
boundary condition: false
name: D-Glucose 1-phosphate

metaR r1588
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110010#

metaM HC00591 m
boundary condition: false
name: 2-oxoglutaramate
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:16769
initial amount: NaN
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
constant: false
initial concentration: 1.0

metaM h2o l
initial amount: NaN
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
is: HMDB02111
name: water
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
type: Species

metaR r1648
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
type: Reaction
reversible: true
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
fast: false
modifier: MODEL1310110010#

metaR r0616
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
type: Reaction
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is described by: ECO:0000000
reversible: true

metaR LNLCCRNt
modifier: MODEL1310110010#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110010#
reversible: false
product: MODEL1310110010#
fast: false
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000185
name: transport into the mitochondria (carnitine)

metaM asn L e
name: L-asparagine
is: CHEBI:17196
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
type: Species
boundary condition: false
is: HMDB00168
has only substance units: false
initial concentration: 1.0

metaR UMPK4n
fast: false
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110010#
name: UMP kinase (GTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110010#

metaM fol e
type: Species
initial concentration: 1.0
has only substance units: false
name: Folate
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN

metaM 2obut m
is: CHEBI:16763
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00005
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
initial concentration: 1.0
name: 2-oxobutanoate
initial amount: NaN
has only substance units: false

metaR INSTt4 2
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000006
name: inositol transport via sodium symport
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000185
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD

metaR GLCNACPT U
is version of: http://identifiers.org/ec-code/2.7.8.15
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
modifier: MODEL1310110010#
fast: false
is: SBO:0000176
type: Reaction

metaR r2511
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
name: Utilized transport
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110010#

metaR D3AIBTm
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
is: SBO:0000176
product: MODEL1310110010#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_c82968a8_fb8d_416d_be67_b04ba35d57bb
is: P54819
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:204
boundary condition: true
name: AK2
constant: false

metaM ksi deg1 l
is: HMDB00174
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 1
is: CHEBI:18287
constant: false
type: Species
boundary condition: false

metaR r1434
reactant: MODEL1310110010#
name: Transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: false
type: Reaction
fast: false
product: MODEL1310110010#

metaR r1587
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110010#

metaM ala B m
is: CHEBI:16958
name: beta-alanine
is: HMDB00056
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN

metaM CE5117 m
constant: false
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
type: Species
initial concentration: 1.0
is: CHEBI:12947
initial amount: NaN
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
is: SBO:0000247
boundary condition: false

metaR PPCDC
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: phosphopantothenoylcysteine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.36
reversible: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
type: Reaction
fast: false
product: MODEL1310110010#

metaM h2o m
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: H2O
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
has only substance units: false
is: C00001
is: CHEBI:15377
is: HMDB02111

metaR r1649
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#

metaR GALK
reactant: MODEL1310110010#
name: galactokinase
product: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.1.6
is version of: http://identifiers.org/ec-code/2.7.1.157
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_03014d78_faad_4c79_a401_6f38ffd0d61a
initial concentration: NaN
name: SLC6A14
boundary condition: true
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: Q9UN76
is encoded by: hsa:11254
initial amount: NaN

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM HC10852 r
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: palmitoleyl-CoA(4-)
initial amount: NaN
is: CHEBI:61540
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_29d48736_84ad_49fd_800f_6a072e9e84fb
boundary condition: true
has only substance units: false
name: ACSL3
type: Species
is encoded by: hsa:2181
is: O95573
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_87809003_a427_47b4_ac22_621a1a44e1a2
constant: false
boundary condition: true
has only substance units: false
is: P00352
initial amount: NaN
name: ALDH1A1
type: Species
is encoded by: hsa:216
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_4f017206_5fb2_46b9_bcf8_a937593eacfc
name: ST3GAL3
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:6487
boundary condition: true

metaM zymstnl r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB06841
name: 5alpha-cholest-8-en-3beta-ol
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16608

metaR ECOAH9m
reversible: true
reactant: MODEL1310110010#
fast: false
is: SBO:0000176
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
modifier: MODEL1310110010#
is described by: ECO:0000304
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
type: Reaction

metaR GLCter
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
name: glucose transport, endoplasmic reticulum
kinetic law: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD

metaR BTNDm
fast: false
is described by: ECO:0000269
name: biotinidase (biotin), mitochondrial
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is: SBO:0000176
reversible: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.12

MODEL1310110010
species: metaM ksi l
species: metaM ksi deg11 l
reaction: metaR r0545
reaction: metaR 2HCO3 NAt
species: metaM atp r
species: metaM 10fthf6glu e
species: metaM Rtotal2 e
species: metaM cit m
species: metaM dgmp c
species: metaM dopa c
species: metaM xoltriol c
species: metaM udpacgal c
reaction: metaR r0504
reaction: metaR SACCD3m
species: metaM lpam m
species: metaM mi145p c
species: metaM mev R x
reaction: metaR r2507
species: metaM HC01406 m
reaction: metaR PSt3
species: metaM h2o x
reaction: metaR r0679
reaction: metaR PSFLIPm
reaction: metaR MECOALm
reaction: metaR r0809
species: metaM gchola x
reaction: metaR r2385
reaction: metaR r0954
species: metaM tyr L e
species: metaM idp e
species: metaM etoh c
reaction: metaR r1302
species: metaM cl e
species: metaM g3m8masn r
reaction: metaR EX co2 LPAREN e RPAREN
reaction: metaR DOPASFt
species: metaM ump r
reaction: metaR EX cmp LPAREN e RPAREN
reaction: metaR ENGASE2ly
species: metaM mthgxl c
reaction: metaR FAOXC226205x
reaction: metaR CYTK13
species: metaM ksii core2 deg9 l
reaction: metaR PECTCHLe
species: metaM coa x
species: metaM thcrm hs g
species: metaM nadph r
reaction: metaR EX for LPAREN e RPAREN
species: metaM pi g
reaction: metaR CYANt
species: metaM ksii core4 pre7 g
reaction: metaR RETH1e
species: metaM fucacgalfucgalacglcgalgluside hs e
reaction: metaR r1377
reaction: metaR r0360
species: metaM glyc e
reaction: metaR r2111
reaction: metaR r1291
reaction: metaR PRPNCOAHYDm
reaction: metaR PRO1xm
reaction: metaR NDPK9n
species: metaM pyr c
species: metaM 3mob c
species: metaM k e
species: metaM thr L e
reaction: metaR NRPPHRt4 2 r
species: metaM dcyt c
reaction: metaR MG3er
species: metaM tdcoa m
reaction: metaR NACHEXA20ly
reaction: metaR RNDR2
species: metaM Rtotal3coa c
reaction: metaR r0885
reaction: metaR UDPtl
reaction: metaR BTNDm
reaction: metaR r2525
species: metaM nadh r
species: metaM na1 c
reaction: metaR PI45PLC
reaction: metaR CYTK8n

metaM retinol e
initial amount: NaN
is: CHEBI:50211
name: retinol
initial concentration: 1.0
has only substance units: false
is: HMDB00305
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
type: Species
constant: false
boundary condition: false

metaR G6PDH1rer
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.47
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110010#

metaM 44mctr r
type: Species
is: SBO:0000247
is: CHEBI:17813
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: HMDB01023
has only substance units: false
initial amount: NaN
constant: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol

metaR r1365
product: MODEL1310110010#
kinetic law: MODEL1310110010#
name: Vesicular transport
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_b3e47888_6e6d_46af_955c_d5a1512ceccd
is encoded by: hsa:4598
boundary condition: true
constant: false
has only substance units: false
name: MVK
type: Species
initial amount: NaN
initial concentration: NaN
is: B2RDU6
is: SBO:0000252

metaR GLNS
kinetic law: MODEL1310110010#
name: glutamine synthetase
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110010#
is described by: ECO:0000254
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.15

metaM CE4876 r
name: delta12-Prostaglandin J2
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:12947
has only substance units: false
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876

http://identifiers.org/biomodels.db/MODEL1310110010#_33981448_c16c_443f_94df_571f957db1d5
is: SBO:0000252
initial concentration: NaN
name: DPYSL3
is: Q8IXW6
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:1809
type: Species

metaM leu L e
type: Species
constant: false
is: HMDB00687
initial concentration: 1.0
name: L-leucine
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:15603

http://identifiers.org/biomodels.db/MODEL1310110010#_9406a6c3_d226_4587_bde3_a51112814d88
is: SBO:0000252
is encoded by: hsa:8781
initial concentration: NaN
initial amount: NaN
name: _8781_1_c
has only substance units: false
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_dee25052_f15f_4535_abae_17d273a466be
constant: false
is encoded by: hsa:U52111
boundary condition: true
has only substance units: false
name: _U52111_1_c
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

metaR r2373
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
reversible: true

metaR RE2626M
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reactant: MODEL1310110010#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110010#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
name: RE2626
is described by: ECO:0000000

metaR ADK3m
reversible: true
name: adentylate kinase (GTP)
type: Reaction
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
kinetic law: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.4.10
reactant: MODEL1310110010#
fast: false

metaR MMMm
is version of: http://identifiers.org/ec-code/5.4.99.2
reversible: true
type: Reaction
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
name: methylmalonyl-CoA mutase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is: SBO:0000176
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#

metaM arachd e
boundary condition: false
initial amount: NaN
is: CHEBI:32395
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
is: HMDB01043
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

metaR r1917
reversible: false
product: MODEL1310110010#
is: SBO:0000185
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR CYSAMOe
fast: false
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
name: CYSAMOe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: false

metaM ddcacoa c
name: Dodecanoyl-CoA (n-C12:0CoA)
is: C01832
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57375
has only substance units: false
initial amount: NaN
is: HMDB03571
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_b3171842_6814_45b2_8127_4fbad0468daa
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:4952
initial concentration: NaN
name: OCRL

metaM abt e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:18403
type: Species
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
boundary condition: false
name: L-arabinitol
is: HMDB01851

metaR MI145PK
is version of: http://identifiers.org/ec-code/2.7.1.127
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
name: inositol-1,4,5-trisphosphate 3-kinase
kinetic law: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reversible: false
type: Reaction

metaR M13N4Tg
reversible: false
fast: false
product: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11320.1) or (11282.2) or (11282.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.145 Confidence Level: 0 AUTHORS: PMID:10024668,PMID:10372966 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.145
modifier: MODEL1310110010#
type: Reaction

metaR G14T14g
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR 3DSPHR
fast: false
reactant: MODEL1310110010#
name: 3-Dehydrosphinganine reductase
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.102
modifier: MODEL1310110010#
is described by: ECO:0000269
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_439e6eec_c593_49d0_9aaa_19547daf6b96
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:1375
name: CPT1B
initial concentration: NaN
is: E9PCP2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_c1ceeed4_3cca_4064_bc36_8ad2f2a56bf5
constant: false
initial amount: NaN
is: P06744
type: Species
boundary condition: true
name: GPI
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2821
has only substance units: false

metaR G14T6g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is: SBO:0000176

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

metaM dtdp c
is: C00363
is: HMDB01274
is: CHEBI:58369
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
initial amount: NaN
constant: false
name: dTDP
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ad5d041c_016f_432c_8c91_8fc4da855b04
initial amount: NaN
name: LDHC
is encoded by: hsa:3948
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_87f910ab_0729_4a21_9855_0c435d1bf3a7
is: P48735
boundary condition: true
initial amount: NaN
is encoded by: hsa:3418
constant: false
name: IDH2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR r2374
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185

metaR r0752
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
type: Reaction
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_9a3f0062_5406_455d_b950_84e71765b549
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: Q8TE04
has only substance units: false
constant: false
is: SBO:0000252
name: PANK1
is encoded by: hsa:53354

metaM ksi deg39 l
is: HMDB00143
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: keratan sulfate I, degradation product 39
is: CHEBI:12936
is: SBO:0000247
notes: FORMULA: C48H81N3O36 CHARGE: 0
boundary condition: false
type: Species
constant: false

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR r1589
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR r1918
modifier: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM retinol c
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: HMDB00305
name: retinol
is: SBO:0000247
is: CHEBI:50211
type: Species

metaM h2o x
has only substance units: false
constant: false
name: H2O
is: C00001
boundary condition: false
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:15377

http://identifiers.org/biomodels.db/MODEL1310110010#_a5be5f23_72a6_44d9_83bd_b6bee4b0152d
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: _AA021081_1_r
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AA021081

http://identifiers.org/biomodels.db/MODEL1310110010#_1e20a0de_84d8_4091_896a_09ac8afcb824
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: _AI291895_1_c
is encoded by: hsa:AI291895
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_34cd21c0_ffc9_4755_b923_05de8edfc96c
type: Species
is: P55084
boundary condition: true
is encoded by: hsa:3032
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: HADHB
constant: false

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_ac7d3f40_74d9_4788_84c3_3d198172c214
initial amount: NaN
constant: false
is encoded by: hsa:1666
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: DECR1
initial concentration: NaN
is: Q16698

metaM m5mpdol U r
initial concentration: 1.0
type: Species
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:37634
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_6bf7f36f_44c3_4f4e_84a3_c7e5cc6e900d
type: Species
constant: false
name: DUOX1
has only substance units: false
is encoded by: hsa:53905
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR RE3004M
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is described by: ECO:0000000
name: RE3004
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#

metaR ACGAMPM
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.4.2.3
modifier: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
kinetic law: MODEL1310110010#
reversible: true
type: Reaction
is: SBO:0000176
name: phosphoacetylglucosamine mutase
fast: false
product: MODEL1310110010#

metaR r2371
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is: SBO:0000185
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
product: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_94d4f61d_c29d_4143_87f9_fb426dc82f8d
is: SBO:0000252
constant: false
initial amount: NaN
is: O75438
is encoded by: hsa:4707
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: NDUFB1

metaR r0355
fast: false
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.3
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
modifier: MODEL1310110010#
product: MODEL1310110010#

metaR r0753
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
product: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:

metaM g3p c
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3930
is: HMDB01112
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: C00661
name: Glyceraldehyde 3-phosphate
is: CHEBI:58027
boundary condition: false

metaR ACACt2
is: SBO:0000185
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
name: acetoacetate transport via proton symport
fast: false
modifier: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000269

metaR BAAT3x
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
reactant: MODEL1310110010#
name: bile acid Coenzyme A: amino acid N-acyltransferase
fast: false
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110010#
is described by: ECO:0000304
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_32a25835_d7da_4bfe_9ac0_0f6a77d26f90
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: _AI620219_1_e
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI620219

http://identifiers.org/biomodels.db/MODEL1310110010#_1df141a8_1f91_49b1_94de_b8b989d46728
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:NM 001929
has only substance units: false
type: Species
name: _NM_001929_1_c
initial amount: NaN

metaM m8masn r
type: Species
constant: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
boundary condition: false
initial concentration: 1.0
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05876
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_10295fc6_83d0_4f50_a09b_e6e3d9bb7abc
type: Species
is: SBO:0000252
is: P05091
initial concentration: NaN
initial amount: NaN
name: ALDH2
boundary condition: true
is encoded by: hsa:217
has only substance units: false
constant: false

metaR ARGt4
type: Reaction
product: MODEL1310110010#
name: L-arginine transport in via sodium symport
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reactant: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000304
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_b3c9777a_f725_44c9_ac3c_eb31a93714db
is encoded by: hsa:D87002
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: _D87002_1_m
initial concentration: NaN
is: SBO:0000252

metaM arachd c
has only substance units: false
is: CHEBI:32395
type: Species
initial amount: NaN
is: SBO:0000247
name: arachidonate
boundary condition: false
initial concentration: 1.0
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
constant: false

metaM 4aphdob c
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: CHEBI:58147
type: Species
is: HMDB00978
has only substance units: false
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252

metaR r1364
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
name: Vesicular transport
reversible: false

metaR CYTK12n
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dCTP),nuclear
is described by: ECO:0000269
modifier: MODEL1310110010#
product: MODEL1310110010#
fast: false

metaR TCYNTt
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is: SBO:0000185
fast: false
product: MODEL1310110010#
name: Thiocyanate transport via diffusion (cytosol to extracellular)
type: Reaction
reactant: MODEL1310110010#
reversible: false
is described by: ECO:0000000

metaM mmcoa S m
name: (S)-methylmalonyl-CoA(5-)
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57327
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
is: HMDB02310
type: Species
is: SBO:0000247

metaR AG13T5g
is described by: ECO:0000000
fast: false
reactant: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM HC01231 c
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
is: CHEBI:58480
type: Species
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false

metaR RE1898C
reactant: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reversible: true
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#
name: RE1898

metaR r0754
fast: false
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
type: Reaction
modifier: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is described by: ECO:0000000
product: MODEL1310110010#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110010#

metaR r2372
type: Reaction
is: SBO:0000185
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
fast: false

metaR EX carn LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for carnosine
type: Reaction

metaM hpyr c
name: 3-hydroxypyruvate
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01352
type: Species
initial concentration: 1.0
is: CHEBI:17180
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168

metaM 2mpdhl m
boundary condition: false
constant: false
initial concentration: 1.0
name: S-(2-Methylpropanoyl)-dihydrolipoamide
has only substance units: false
is: SBO:0000247
is: CHEBI:17577
initial amount: NaN
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
type: Species

metaM dtdp e
constant: false
boundary condition: false
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:58369
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: SBO:0000247
is: HMDB01274

metaM abt c
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: SBO:0000247
name: L-arabinitol
is: CHEBI:18403
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: HMDB01851
initial concentration: 1.0

metaR RE0453M
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
modifier: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453
fast: false
kinetic law: MODEL1310110010#

metaM lnlncg l
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: SBO:0000247
type: Species
has only substance units: false
name: gamma-linolenate
is: HMDB03073
boundary condition: false
initial amount: NaN
is: CHEBI:32391
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_bbd077cb_498e_4894_84fe_22e8d0b8ad99
is: SBO:0000252
is: P00390
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:2936
constant: false
name: GSR
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_1854c268_6478_4921_af5c_7b485d6aa5e8
initial concentration: NaN
is encoded by: hsa:5332
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: PLCB4
has only substance units: false
boundary condition: true
is: E2QRH8

metaM carn e
type: Species
constant: false
is: HMDB00033
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15727
name: carnosine
notes: FORMULA: C9H14N4O3 CHARGE: 0 INCHI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
is: SBO:0000247

metaR SPODMm
fast: false
is version of: http://identifiers.org/ec-code/1.15.1.1
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
reversible: false
modifier: MODEL1310110010#
type: Reaction
name: superoxide dismutase
reactant: MODEL1310110010#
is described by: ECO:0000304
kinetic law: MODEL1310110010#

metaR r2404
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
reversible: false

metaR APOCFm
reversible: false
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
is described by: ECO:0000000
name: Apocarboxylase formation, mitochondrial
reactant: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_5e31361c_a371_4400_b77f_9e8601366d68
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:8613
initial amount: NaN
name: PPAP2B
type: Species
is: O14495
has only substance units: false

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR RBTt
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110010#
is: SBO:0000185
reversible: false
fast: false
name: ribitol transport via passive diffusion
is described by: ECO:0000000
type: Reaction

metaR DURIt
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: deoxyuridine transport via diffusion
reactant: MODEL1310110010#

metaM ksi deg20 l
type: Species
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
has only substance units: false
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate I, degradation product 20
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_16a3f962_fd8b_4633_95bb_ba33874089f4
constant: false
boundary condition: true
initial amount: NaN
is: Q9NRR6
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: INPP5E
is encoded by: hsa:56623

metaR CITRtm
reactant: MODEL1310110010#
name: citrulline mitochondrial transport via proton antiport
modifier: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110010#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110010#_97531b67_e570_4716_8159_1781709836aa
is: Q92911
constant: false
has only substance units: false
is: SBO:0000252
name: SLC5A5
is encoded by: hsa:6528
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

metaM bilglcur r
has only substance units: false
initial amount: NaN
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
initial concentration: 1.0
constant: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
is: SBO:0000247
boundary condition: false

metaM 34dhmald m
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
boundary condition: false
is: http://identifiers.org/pubchem.compound/7903
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB06242
type: Species
is: C05577
initial concentration: 1.0
has only substance units: false
name: 3,4-Dihydroxymandelaldehyde

metaR RE0453N
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
kinetic law: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: RE0453
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
fast: false

metaR MI145PP
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
name: inositol-1,4,5-trisphosphate 5-phosphatase
type: Reaction
modifier: MODEL1310110010#
is described by: ECO:0000269
kinetic law: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_6b892350_0609_4725_ba1f_d92aa9102066
initial amount: NaN
has only substance units: false
name: SUCLG1
initial concentration: NaN
is: P53597
is encoded by: hsa:8802
is: SBO:0000252
boundary condition: true
constant: false
type: Species

metaR ALDD2y
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
reactant: MODEL1310110010#
reversible: false
is described by: ECO:0000000
product: MODEL1310110010#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
fast: false
type: Reaction
modifier: MODEL1310110010#

metaM hxan c
is: HMDB00157
has only substance units: false
is: CHEBI:17368
constant: false
is: C00262
type: Species
boundary condition: false
initial concentration: 1.0
name: Hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_8dfc93fe_428b_42e2_8f84_481c5aada49f
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6240
boundary condition: true
initial concentration: NaN
is: P23921
type: Species
initial amount: NaN
name: RRM1
constant: false

metaR r2377
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
fast: false
reversible: true
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaR r0755
reversible: true
product: MODEL1310110010#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_afb0dcbf_1ee6_4cbf_a963_ab8f9ce5057c
is encoded by: hsa:37
is: SBO:0000252
has only substance units: false
name: ACADVL
is: P49748
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

metaR TDCHOLAte
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110010#
reversible: true
type: Reaction

metaR ABTD
reactant: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: L-arabinitol 4-dehydrogenase
product: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD

metaM apoC Lys m
notes: FORMULA: C6H13N2OX CHARGE: 0
constant: false
has only substance units: false
is: CHEBI:32551
initial amount: NaN
is: SBO:0000247
is: HMDB00182
type: Species
initial concentration: 1.0
boundary condition: false
name: Apocarboxylase (Lys residue)

metaR r2378
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110010#
reversible: true
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110010#

metaM 2obut c
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
initial concentration: 1.0
is: C00109
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16763
type: Species
boundary condition: false
name: 2-Oxobutanoate
is: HMDB00005
constant: false

metaM nicrnt c
has only substance units: false
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
type: Species
is: C01185
is: HMDB01132
is: CHEBI:57502
is: SBO:0000247
name: Nicotinate D-ribonucleotide
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaM CE2418 m
is: SBO:0000247
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
initial concentration: 1.0
is: CHEBI:28387
boundary condition: false
initial amount: NaN
constant: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
has only substance units: false
type: Species
is: HMDB11123

metaM CE5788 e
initial amount: NaN
initial concentration: 1.0
is: HMDB02710
name: kinetensin 1-7
boundary condition: false
is: CHEBI:27485
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788

metaM core2 g
initial amount: NaN
type: Species
name: Core 2
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C22H37N2O15X CHARGE: 0
has only substance units: false
constant: false
is: CHEBI:15876
boundary condition: false

metaR ALDD2x
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000176
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
fast: false
type: Reaction
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_ca929cd2_11f6_47ca_b264_c6f202da7320
is encoded by: hsa:3033
constant: false
is: Q16836
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: HADH
initial amount: NaN
has only substance units: false

metaR FAEL183
type: Reaction
kinetic law: MODEL1310110010#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
reversible: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is: SBO:0000176
fast: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_da1d369d_b60c_418f_aa5d_9733327aa61d
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1956
is: P00533
name: EGFR
constant: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_fe05a930_7598_48fb_873a_0b07d93f486d
initial amount: NaN
is: SBO:0000252
name: _X63359_1_c
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:X63359
boundary condition: true
type: Species

metaM pnto R c
is: SBO:0000247
type: Species
is: CHEBI:7916
is: HMDB00210
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: (R)-Pantothenate
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false

metaR TRDR
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.9
name: thioredoxin reductase (NADPH)
kinetic law: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is described by: ECO:0000269
reversible: false

metaR MMEm
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
is version of: http://identifiers.org/ec-code/5.1.99.1
reversible: true
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000269
name: methylmalonyl-CoA epimerase/racemase
modifier: MODEL1310110010#

metaM dhcholestanate c
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00359

metaM ksi pre10 g
boundary condition: false
is: C00130
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 10
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
constant: false
is: SBO:0000247
is: HMDB00175
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_f2308a25_5588_4eda_9512_edde968870cf
constant: false
is: SBO:0000252
name: MAOA
boundary condition: true
is: Q53YE7
is encoded by: hsa:4128
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM duri n
is: CHEBI:16450
name: 2'-deoxyuridine
is: HMDB00012
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaR NH4t3r
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: ammonia transport via proton antiport
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
fast: false
reactant: MODEL1310110010#
is: SBO:0000185
modifier: MODEL1310110010#
reversible: true
is described by: ECO:0000269

metaR GLUDym
reactant: MODEL1310110010#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reversible: true
product: MODEL1310110010#
name: glutamate dehydrogenase (NADP), mitochondrial
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.1.3
modifier: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_ade8de17_c835_4ce6_ad42_0f4d9abd96cb
name: ALG3
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: Q92685
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:10195

http://identifiers.org/biomodels.db/MODEL1310110010#_e487ab76_d917_4b3f_a0ad_96ab904b5306
has only substance units: false
initial concentration: NaN
name: SULT1A3
is encoded by: hsa:6818
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM fol m
is: HMDB00121
name: Folate
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:27470
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_cdc38b50_2b60_4a5b_b575_5d4198dd4379
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51703
initial amount: NaN
is: Q9ULC5
name: ACSL5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_38357b64_6fbe_4bd5_84c7_6422b4a06512
constant: false
boundary condition: true
name: PRDX1
has only substance units: false
is: SBO:0000252
type: Species
is: Q06830
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5052

metaR r2497
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
reversible: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_b77d9613_d0bf_4a55_bfa7_5b8a387be88c
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q9P2T1
name: GMPR2
is encoded by: hsa:51292

metaM leu L c
initial concentration: 1.0
is: CHEBI:15603
constant: false
type: Species
is: HMDB00687
name: L-leucine
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM idp n
is: HMDB03335
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
name: IDP(3-)
boundary condition: false
is: CHEBI:58280
is: SBO:0000247
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

metaR r2375
is: SBO:0000185
product: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
kinetic law: MODEL1310110010#

metaM HC01397 x
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
constant: false
boundary condition: false
type: Species
initial amount: NaN
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: CHEBI:27402

metaR GLYt7 211 r
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#
is: SBO:0000185
name: glycine reversible transport via sodium and chloride symport (2:1:1)
type: Reaction
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000269

metaR CYTK6n
type: Reaction
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: cytidylate kinase (CMP,CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_7837a34e_0bbb_4ebf_bd2b_770725212c13
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: ACOX3
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:8310
is: O15254

http://identifiers.org/biomodels.db/MODEL1310110010#_8eadfe4f_1fb9_48c0_94b2_033852bfd671
is encoded by: hsa:W74642
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: _W74642_1_c
has only substance units: false
initial concentration: NaN

metaR SO4tl
reversible: true
fast: false
name: Sulfate transport (lysosome)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000269

metaM pnto R e
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:7916
type: Species
is: HMDB00210
name: (R)-Pantothenate

metaR APOC LYS BTNP
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110010#
reversible: false
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000176
name: proteolysis of apoC-Lys-btn
reactant: MODEL1310110010#
is described by: ECO:0000000

metaM no c
is: C00533
is: HMDB03378
initial amount: NaN
has only substance units: false
is: CHEBI:16480
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: Nitric oxide
is: SBO:0000247
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533

http://identifiers.org/biomodels.db/MODEL1310110010#_7e85575b_5908_4051_8357_9943387b5ece
name: PLCH1
has only substance units: false
constant: false
initial amount: NaN
is: Q4KWH8
is encoded by: hsa:23007
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_d09cc56d_e9ec_433b_89dd_08bccb077150
is: E9PHN8
name: HEPH
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:9843
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_3457f0d4_cb12_4611_9b90_993852853a7f
has only substance units: false
is encoded by: hsa:8801
has part: P53597
name: SUCLG2:SUCLG1
is encoded by: hsa:8802
has part: Q96I99
is: SBO:0000297
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR r2376
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: true
type: Reaction

metaR r0541
fast: false
type: Reaction
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is: SBO:0000176
product: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_4f7eb9a0_67c4_4880_aa32_7036ce1bf2bf
boundary condition: true
name: CCBL1
constant: false
is encoded by: hsa:883
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q16773
type: Species
is: SBO:0000252

metaM nrpphr e
boundary condition: false
name: Norepinephrine
has only substance units: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: SBO:0000247
type: Species
is: HMDB00216
initial concentration: 1.0
is: CHEBI:33569
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_fa330472_f06a_4ad1_ad81_c0c0c56e0cc5
initial concentration: NaN
has only substance units: false
name: PCBD1
is: P61457
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5092
type: Species
boundary condition: true
constant: false

metaM ksi pre5 g
notes: FORMULA: C101H164N7O75SX CHARGE: -2
initial amount: NaN
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 5
is: CHEBI:28067
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM apoC Lys c
is: HMDB00182
is: SBO:0000247
name: Apocarboxylase (Lys residue)
has only substance units: false
is: CHEBI:32551
notes: FORMULA: C6H13N2OX CHARGE: 0
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_24a53fb3_d081_432e_80f3_f35c3df04d4b
boundary condition: true
is: P13196
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:211
name: ALAS1
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_504f78c0_1d47_4e89_9761_3ccc04922221
is: SBO:0000297
constant: false
has part: P23434
has part: P48728
initial amount: NaN
is encoded by: hsa:2653
has part: P09622
is encoded by: hsa:1738
has part: P23378
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:275
is encoded by: hsa:2731

metaM aps c
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
type: Species
constant: false
is: HMDB01003
initial amount: NaN
initial concentration: 1.0
name: 5'-adenylyl sulfate(2-)
is: SBO:0000247
is: CHEBI:58243
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_4410d609_3d9d_4e57_847d_ab0d3006561a
constant: false
type: Species
initial amount: NaN
name: PMM1
is: SBO:0000252
is: A8K003
initial concentration: NaN
is encoded by: hsa:5372
has only substance units: false
boundary condition: true

metaM gln L c
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
type: Species
boundary condition: false
initial concentration: 1.0
name: L-glutamine
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:18050

metaR r1735
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110010#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_97e33a07_6319_456d_b9f6_fa694f64710d
is encoded by: hsa:4830
name: NME1:NME2
initial concentration: NaN
has part: P22392
is: SBO:0000297
constant: false
has part: P15531
is encoded by: hsa:4831
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_a18efc0f_9f48_4992_9b7d_b4d1981e5928
is: SBO:0000252
is encoded by: hsa:80308
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: FLAD1

http://identifiers.org/biomodels.db/MODEL1310110010#_0ce906cb_5d89_4e82_ae26_af66ab3ca2df
boundary condition: true
constant: false
type: Species
is encoded by: hsa:376497
has only substance units: false
name: SLC27A1
is: Q6PCB7
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR r0940
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110010#
name: Free diffusion
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110010#

metaR CAATPS
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000269
name: Ca ATPase
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.6.3.8
reversible: false
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
product: MODEL1310110010#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_9383e34d_9425_447f_b09f_5f3664e26bb9
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ACSS1
is encoded by: hsa:84532
constant: false
type: Species
is: Q9NUB1
boundary condition: true
is: SBO:0000252

metaM mn l
is: HMDB06535
initial amount: NaN
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
name: beta-1,4-mannose-N-acetylglucosamine

http://identifiers.org/biomodels.db/MODEL1310110010#_dad9c613_6c7d_4e1d_8c5a_6f4a33064906
constant: false
initial concentration: NaN
is: Q96C36
is encoded by: hsa:29920
name: PYCR2
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_c2a7dc32_1d6c_4279_82f6_6ce6dae25043
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: SCP2
is: C9JC79
constant: false
initial concentration: NaN
is encoded by: hsa:6342
is: SBO:0000252

metaM 7dhf e
constant: false
initial concentration: 1.0
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
boundary condition: false
is: HMDB06559
initial amount: NaN
has only substance units: false
name: heptaglutamyl folate (DHF)
type: Species
is: SBO:0000247

metaR ECOAH12m
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
modifier: MODEL1310110010#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)

metaR DHORD9
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.5.2
reactant: MODEL1310110010#
type: Reaction
reversible: false
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
is described by: ECO:0000269
product: MODEL1310110010#
name: dihydoorotic acid dehydrogenase (quinone10)
is: SBO:0000185

metaM CE2432 m
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
is: C01936
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
type: Species

metaR MTHFD2
product: MODEL1310110010#
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD)
is: SBO:0000176
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
reversible: true
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.5.4.9

metaM tag hs c
constant: false
boundary condition: false
name: triglyceride
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: CHEBI:17855
initial amount: NaN
type: Species

metaM man1p c
constant: false
type: Species
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
name: D-Mannose 1-phosphate
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:35374
is: HMDB06330
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_3a6705cf_648d_4787_9c75_7c97cc96f020
name: NMNAT3
is: Q96T66
initial concentration: NaN
is encoded by: hsa:349565
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_fa659e07_5e0d_4d26_8704_beddac6fd04b
is: O95168
boundary condition: true
has only substance units: false
constant: false
name: NDUFB4
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4710
initial amount: NaN

metaM ser L c
constant: false
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
is: HMDB00187

metaR r1787
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
product: MODEL1310110010#

metaM ser D e
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: SBO:0000247
is: HMDB03406
initial concentration: 1.0
constant: false
name: D-serine
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:16523

http://identifiers.org/biomodels.db/MODEL1310110010#_5fe278d7_a238_4d29_b533_0ddc6adabb01
name: PEMT
is: SBO:0000252
is encoded by: hsa:10400
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: NaN

metaM Rtotal2coa c
name: R total 2 coenzyme A
is: HMDB00095
initial concentration: 1.0
is: CHEBI:60377
has only substance units: false
boundary condition: false
is: C00055
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110010#_0ac92311_a29c_484e_9809_5f036ff6e0b1
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: P00374
initial concentration: NaN
is encoded by: hsa:1719
name: DHFR
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_1034ff98_388a_4043_aff1_1714f9a68949
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23600
name: AMACR
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: Q9UHK6

metaM 10fthf6glu e
is: CHEBI:57454
is: SBO:0000247
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](6)
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00972
type: Species
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
boundary condition: false

metaM adp m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: ADP
type: Species
is: SBO:0000247
is: CHEBI:456216
is: HMDB01341
has only substance units: false
is: C00008
is: http://identifiers.org/pubchem.compound/3310
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_aa58859b_be81_4f1b_95be_75dd510a437d
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _LOC728997_1_c
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:LOC728997
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_2b2729b9_8eed_4990_930b_4d591966d3fc
has only substance units: false
name: SLC7A5
constant: false
initial amount: NaN
is: SBO:0000252
is: Q8IV97
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8140

metaR DOLPH Uer
product: MODEL1310110010#
reversible: false
name: Dolichol-phosphate phosphohydrolase, human (uterus)
is described by: ECO:0000000
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_530cfeee_cf2c_468e_ae16_1c11167420e6
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:203
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P00568
name: AK1
constant: false

metaM udpglcur r
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
has only substance units: false
boundary condition: false
is: HMDB00935
type: Species
is: SBO:0000247
constant: false
name: UDP-D-glucuronate
initial concentration: 1.0
is: CHEBI:58052
is: C00167

metaM nrpphr c
initial amount: NaN
name: Norepinephrine
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00216
is: CHEBI:33569

metaM pyr e
is: CHEBI:15361
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
type: Species
is: HMDB00243
initial amount: NaN
name: pyruvate
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false

metaM gln L e
type: Species
boundary condition: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial concentration: 1.0
constant: false
name: L-glutamine
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:18050
is: HMDB00641

metaR ACt2m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
type: Reaction
is described by: ECO:0000000
name: acetate mitochondrial transport via proton symport
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_81477f5c_09b6_4e9a_92ce_67a32df7a420
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: FOLR3
boundary condition: true
is encoded by: hsa:2352
is: Q05C14

metaM tetpent3coa x
initial amount: NaN
type: Species
is: C16167
name: tetracosapentaenoyl coenzyme A, n-3
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM dpcoa c
name: Dephospho-CoA
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57328
is: HMDB01373
is: C00882
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882

metaR r1147
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110010#

metaR CYANtm
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
reversible: true
name: Cyanide transport via diffusion (mitochondrial)

metaR RE3346C
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
name: RE3346
reactant: MODEL1310110010#
reversible: true
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM ddcacoa x
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB03571
initial amount: NaN
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)
is: C01832
is: CHEBI:57375
constant: false
boundary condition: false

metaR PROSTGE2t2
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000269
reversible: true
name: prostaglandin uniport
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction

metaR PHACCOAGLNAC
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
product: MODEL1310110010#
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110010#

metaR 5OXPROt
type: Reaction
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
reversible: true
name: Transport of 5-oxoprolinate
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_9a8b2d0b_57da_4b64_b946_dc1cf5266e85
is encoded by: hsa:9245
is: O95395
type: Species
initial amount: NaN
has only substance units: false
name: GCNT3
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaM s2l2n2m2mn l
boundary condition: false
initial concentration: 1.0
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
has only substance units: false
is: CHEBI:57312
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C76H123N5O57 CHARGE: -2
is: HMDB01356
initial amount: NaN

metaR GTHPe
name: glutathione peroxidase (e)
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.11.1.9
is: SBO:0000176
modifier: MODEL1310110010#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2878.1) or (257202.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:3619451 NOTES:SAB
type: Reaction

metaR r1737
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#

metaM malthp e
has only substance units: false
name: maltoheptaose
constant: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: C01936
is: SBO:0000247

metaM acgam1p c
has only substance units: false
is: HMDB01367
is: CHEBI:7125
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species
name: N-Acetyl-D-glucosamine 1-phosphate
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256

metaR S23T2g
product: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)

metaR FAS80COA L
product: MODEL1310110010#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110010#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
modifier: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

metaM 34dhphe e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
is: CHEBI:15765
is: HMDB00181
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: L-dopa
type: Species

metaM m2mn l
has only substance units: false
is: HMDB06537
constant: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
is: SBO:0000247
type: Species
initial amount: NaN

metaM creat c
initial amount: NaN
is: HMDB00064
constant: false
is: CHEBI:16919
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
type: Species
initial concentration: 1.0
name: creatine
boundary condition: false
has only substance units: false

metaM 1pyr5c c
is: C03912
name: 1-Pyrroline-5-carboxylate
boundary condition: false
is: CHEBI:15893
is: SBO:0000247
constant: false
type: Species
is: HMDB01301
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR r1148
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Active transport
reactant: MODEL1310110010#
product: MODEL1310110010#

metaM gdpfuc c
constant: false
has only substance units: false
is: HMDB01095
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57984
type: Species
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
name: GDP-L-fucose(2-)

metaM xol7ah3 m
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
name: 5beta-cholestane-3alpha,7alpha,26-triol
type: Species
has only substance units: false
is: CHEBI:28540
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB12455

metaM ser D c
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
type: Species
name: D-serine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB03406
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16523

http://identifiers.org/biomodels.db/MODEL1310110010#_94813026_b272_4d86_8fca_5a2260fc0e4b
initial amount: NaN
is encoded by: hsa:55350
initial concentration: NaN
boundary condition: true
type: Species
name: VNN3
constant: false
has only substance units: false
is: SBO:0000252

metaR NADHtru
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
name: NADH transporter, endoplasmic reticulum
reversible: false
type: Reaction
fast: false
product: MODEL1310110010#
is: SBO:0000185

metaM ser L e
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00187
initial concentration: 1.0
is: CHEBI:17115
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068

metaM gd3 hs g
has only substance units: false
type: Species
is: CHEBI:28424
is: SBO:0000247
constant: false
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
name: GD3
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR VD3
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
kinetic law: MODEL1310110010#
type: Reaction
name: Vitamin D3 formation
is: SBO:0000176
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000134
product: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_86e8a6cd_4eb5_4589_9ab9_619904474bf0
name: _AL525798_1_c
is encoded by: hsa:AL525798
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaM pmtcoa c
is: SBO:0000247
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
boundary condition: false
constant: false
is: C00154
initial amount: NaN
is: HMDB01338
is: CHEBI:3454
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
type: Species

metaR DM btn
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for biotin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_b3a05bff_5d03_4145_9b8a_b38af4f6e286
name: MGAT4B
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:11282
initial amount: NaN

metaM 2mbcoa m
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:57336
is: SBO:0000247
name: 2-methylbutanoyl-CoA(4-)
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: HMDB01041
initial amount: NaN
boundary condition: false

metaR GAPD
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is version of: http://identifiers.org/ec-code/1.2.1.12
type: Reaction
fast: false
kinetic law: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#
is: SBO:0000176
name: glyceraldehyde-3-phosphate dehydrogenase
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110010#_36a92cd0_758d_4760_9f4c_33e08c760c8f
initial amount: NaN
is encoded by: hsa:1632
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P42126
type: Species
constant: false
name: ECI1

metaR RE1530C
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
name: RE1530
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is: SBO:0000176
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#

metaR r1671
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
name: Y+LAT2 Utilized transport
product: MODEL1310110010#
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#

metaM CE4872 c
has only substance units: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15748
boundary condition: false
type: Species
constant: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: HMDB00127

metaM HC02206 e
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
name: prostaglandin C1(1-)
constant: false
initial concentration: 1.0
is: CHEBI:57399

metaM dgdp c
is: CHEBI:58595
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C00361
is: HMDB00960
name: dGDP
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN
type: Species

metaR DSAT
reactant: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
fast: false
type: Reaction
kinetic law: MODEL1310110010#
reversible: false
is described by: ECO:0000000
name: dihydrosphingosine N-acyltransferase

metaR CLFORtex
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
is: SBO:0000185
name: chloride transport via formate countertransport
is described by: ECO:0000304
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ad960943_f30e_4988_b389_b267b82b58e1
type: Species
is: SBO:0000252
is: Q9UGB7
has only substance units: false
name: MIOX
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:55586

metaR r0093
product: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
fast: false
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.5.1.3
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
is: SBO:0000176

metaM ksii core2 pre7 g
has only substance units: false
constant: false
is: C00130
initial concentration: 1.0
notes: FORMULA: C67H108N5O51SX CHARGE: -2
name: keratan sulfate II biosynthesis, precursor 7
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:58053
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110010#_84a3416c_b1c0_4525_96b8_9872142ee71b
is: SBO:0000252
type: Species
name: AKR1A1
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:10327
boundary condition: true

metaR r0002
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
is described by: ECO:0000000
name: Active transport
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true

metaR ADNt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
fast: false
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: true
name: adenosine facilated transport in cytosol
is described by: ECO:0000269
reactant: MODEL1310110010#
is: SBO:0000185
modifier: MODEL1310110010#

metaM digalsgalside hs g
is: C06127
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
name: Digalactosylceramidesulfate
type: Species
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/8384
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_d9d4098a_fa56_4a62_b2cb_1cd2235af8eb
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2585
name: GALK2
type: Species
is: SBO:0000252
constant: false

metaR C40CPT1
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaR GGLUCT
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
is described by: ECO:0000269
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.2.4
name: gamma-glutamylcyclotransferase
type: Reaction
modifier: MODEL1310110010#
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#

metaR r1784
reversible: false
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110010#
name: Y+LAT2 Utilized transport
type: Reaction

metaM dopasf c
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:37946
constant: false
is: HMDB06275
type: Species
name: dopamine 3-O-sulfate
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
boundary condition: false

metaM ksi pre35 g
is: CHEBI:28067
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 35
has only substance units: false
is: SBO:0000247

metaM CE4790 m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial concentration: 1.0
is: CHEBI:12947
type: Species

metaR r1670
is: SBO:0000185
reactant: MODEL1310110010#
name: Y+LAT2 Utilized transport
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
is described by: ECO:0000000
modifier: MODEL1310110010#
product: MODEL1310110010#

metaM gly x
constant: false
initial amount: NaN
is: HMDB00123
is: CHEBI:15428
boundary condition: false
name: glycine
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false

metaM udpg c
name: UDPglucose
is: HMDB00286
boundary condition: false
is: CHEBI:58367
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: C00029
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial amount: NaN
initial concentration: 1.0

metaM hyptaur e
initial concentration: 1.0
is: CHEBI:16668
boundary condition: false
is: SBO:0000247
name: Hypotaurine
has only substance units: false
is: HMDB00965
type: Species
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
constant: false
initial amount: NaN

metaM val L m
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
name: L-valine
type: Species
is: HMDB00883
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16414

metaM 34dhphe c
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15765
is: SBO:0000247
type: Species
name: L-dopa
boundary condition: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
has only substance units: false
is: HMDB00181

http://identifiers.org/biomodels.db/MODEL1310110010#_73626b15_7a8d_4e09_968a_94b014df0d9f
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: UAP1L1
is: Q3KQV9
is encoded by: hsa:91373
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ed684c4b_b68c_44d0_b8e8_33b8bb378a26
has only substance units: false
is: Q9NRZ7
initial concentration: NaN
name: AGPAT3
is encoded by: hsa:56894
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaM taur x
initial concentration: 1.0
is: HMDB00251
boundary condition: false
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
has only substance units: false
type: Species
is: CHEBI:15891
is: SBO:0000247
constant: false
name: taurine

metaR IDPtn
name: IDP nuclear transport
is: SBO:0000185
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
reversible: true

metaR FERO
is described by: ECO:0000134
fast: false
is: SBO:0000176
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
name: ferroxidase
modifier: MODEL1310110010#
reversible: false
type: Reaction

metaR SUCOASm
reactant: MODEL1310110010#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
name: Succinate--CoA ligase (ADP-forming)
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
product: MODEL1310110010#

metaR ASNATB0tc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the intestinal cells by ATB0 transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_823afd8c_295d_4a6e_a438_80fdffc77b77
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6482
boundary condition: true
type: Species
name: ST3GAL1
is: Q11201
constant: false
is: SBO:0000252

metaR CGLYt3 2
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
name: Cys-Gly transport in via proton symport
modifier: MODEL1310110010#
type: Reaction
is described by: ECO:0000304
reversible: false

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_39a85902_c369_4c06_bfa4_9c141af93822
name: CYP27A1
is encoded by: hsa:1593
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q02318
constant: false
boundary condition: true

metaR DM ethamp r
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_99d1e992_693c_44b7_98a9_ec6aac497470
initial concentration: NaN
is: SBO:0000252
name: _BE042354_1_m
has only substance units: false
is encoded by: hsa:BE042354
boundary condition: true
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_46921dcd_a1d8_465f_a16b_ee54bb508bd6
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: ALDH7A1
boundary condition: true
is encoded by: hsa:501
has only substance units: false
is: E7EPT3

http://identifiers.org/biomodels.db/MODEL1310110010#_ab4837ff_378d_4bc3_ad23_da4ae61610fb
has only substance units: false
is encoded by: hsa:3283
constant: false
is: SBO:0000252
name: HSD3B1
initial concentration: NaN
boundary condition: true
type: Species
is: P14060
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_ffabbd36_0220_435a_aaf2_64832aab35a8
is encoded by: hsa:34
is: SBO:0000252
is: P11310
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: ACADM

http://identifiers.org/biomodels.db/MODEL1310110010#_a5a4a823_0a5c_4f27_b2ab_b62bdd2d3954
type: Species
is encoded by: hsa:65985
name: AACS
is: Q86V21
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR ASPPROASCT1
kinetic law: MODEL1310110010#
name: aspartate intake by system ASCT-1 transporter
modifier: MODEL1310110010#
reversible: false
is described by: ECO:0000134
fast: false
product: MODEL1310110010#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
reactant: MODEL1310110010#

metaR SUCD1m
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000134
product: MODEL1310110010#
type: Reaction
name: succinate dehydrogenase
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.5.1
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
modifier: MODEL1310110010#

metaM adp n
is: CHEBI:456216
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
name: ADP(3-)
constant: false
is: HMDB01341
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_751a43d5_eb78_4231_83e3_4535c68cc269
is encoded by: hsa:57835
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: SLC4A5
has only substance units: false
constant: false

metaR Coqe
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of q10
is described by: ECO:0000134
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_ecf746d0_e67b_4d2f_970e_c2099c6ff5e0
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: VNN2
is encoded by: hsa:8875
is: A8K7W0

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR RE1836X
is: SBO:0000176
kinetic law: MODEL1310110010#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
is described by: ECO:0000000
name: RE1836
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.176
fast: false
reactant: MODEL1310110010#
product: MODEL1310110010#

metaM grdp x
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: CHEBI:58057
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: geranyl diphosphate(3-)
is: HMDB01285
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_a2cbdc06_2cc3_46b8_a6a2_f0dfe328cf84
is: Q9UEF7
type: Species
is encoded by: hsa:9365
initial concentration: NaN
initial amount: NaN
name: KL
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaM g3m8masn r
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
initial amount: NaN
is: C05873
notes: FORMULA: C88H147N2O70X CHARGE: 0

metaM 5adtststerone r
is: HMDB02961
has only substance units: false
is: CHEBI:16330
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
initial concentration: 1.0

metaM gbside hs g
initial amount: NaN
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:18259
initial concentration: 1.0
type: Species
constant: false
name: globoside

http://identifiers.org/biomodels.db/MODEL1310110010#_0b000c39_895f_4a17_84e0_77f6ac922021
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: D3DX95
is encoded by: hsa:1103
constant: false
is: SBO:0000252
name: CHAT

metaR MM5ag
fast: false
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.113
modifier: MODEL1310110010#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110010#
type: Reaction
is: SBO:0000176

metaM hyptaur c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16668
boundary condition: false
name: Hypotaurine
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00965
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
constant: false

metaM udpg e
is: SBO:0000247
is: CHEBI:58367
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial concentration: 1.0
is: HMDB00286
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate

metaM gdpfuc g
boundary condition: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: HMDB01095
initial amount: NaN
is: CHEBI:57984
name: GDP-L-fucose(2-)
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_affe9597_776d_4c32_bb19_5abee0094f21
is encoded by: hsa:204
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: AK2

metaM tag hs e
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
name: triglyceride
constant: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: CHEBI:17855
initial amount: NaN
initial concentration: 1.0

metaR ANTHte
name: Transport of anthranilate
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000134
reversible: true
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM arachdcrn c
has only substance units: false
constant: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01322
is: CHEBI:57387
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_4d6c02ce_da78_4b48_95bd_79abd0dd13e4
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:79369
boundary condition: true
initial amount: NaN
name: B3GNT4
type: Species
constant: false
is: Q9C0J1
has only substance units: false

metaR ABO1g
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000176
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
fast: false
modifier: MODEL1310110010#
is described by: ECO:0000269
product: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.37
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_307a7bde_26c5_4508_b868_cabb8e1772bf
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10449
has only substance units: false
name: ACAA2
constant: false
is: SBO:0000252
is: P42765
initial amount: NaN
type: Species

metaM ppi x
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Diphosphate
boundary condition: false
initial amount: NaN
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
type: Species
has only substance units: false
is: C00013

metaR 3MOBte
is described by: ECO:0000134
product: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-methyl-2-oxobutanoate

http://identifiers.org/biomodels.db/MODEL1310110010#_a9823ae7_a07b_4f6e_a8fa_435246b317da
boundary condition: true
name: SLC25A19
initial concentration: NaN
is: Q9HC21
type: Species
is encoded by: hsa:60386
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

metaR VALTA
is: SBO:0000176
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000269
product: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
name: valine transaminase
kinetic law: MODEL1310110010#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR r1734
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110010#

metaM maltpt e
is: HMDB01296
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
boundary condition: false
is: SBO:0000247
constant: false
name: maltopentaose
is: C02052
type: Species
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5141
initial concentration: 1.0

metaR AHEXASE2ly
product: MODEL1310110010#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR KCCt
type: Reaction
product: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
name: K+-Cl- cotransport
reactant: MODEL1310110010#
is described by: ECO:0000269
modifier: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
fast: false

metaM leuktrD4 e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
initial amount: NaN
is: HMDB03080
type: Species
is: SBO:0000247
name: Leukotriene D4
has only substance units: false
is: CHEBI:28666

metaM digalsgalside hs c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/8384
initial amount: NaN
is: C06127
name: Digalactosylceramidesulfate
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127

metaR FORtr
reactant: MODEL1310110010#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: FOR transporter, endoplasmic reticulum
is: SBO:0000185

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaR G13MT U
is described by: ECO:0000000
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
is: SBO:0000176
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
modifier: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.132
reactant: MODEL1310110010#
fast: false

metaR NACHEXA21ly
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110010#
type: Reaction
fast: false
product: MODEL1310110010#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110010#
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110010#_d5afb596_6b1f_47b8_b312_d43ea2eddb65
constant: false
initial amount: NaN
is encoded by: hsa:53354
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PANK1
boundary condition: true
is: Q8TE04
type: Species

metaR PAIL45P HStn
is: SBO:0000185
product: MODEL1310110010#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110010#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_a64d8a9b_89b1_4a3e_a53f_85b1a787d389
initial amount: NaN
boundary condition: true
is: Q92835
name: INPP5D
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3635
constant: false
has only substance units: false
type: Species

metaM ksii core2 pre10 g
name: keratan sulfate II biosynthesis, precursor 10
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:28067
boundary condition: false
type: Species
notes: FORMULA: C81H130N6O64S2X CHARGE: -3

metaR PNTK
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
modifier: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
fast: false
name: pantothenate kinase
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000269

metaR MM6bg
reactant: MODEL1310110010#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110010#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.113
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false

metaM ddcacoa m
is: C01832
constant: false
is: CHEBI:57375
has only substance units: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
type: Species
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0
boundary condition: false
is: HMDB03571
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_52b898e7_d0e9_4da1_89d7_160f8cbbb3ba
name: GGT3P
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:2679
type: Species

metaM pa hs r
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: phosphatidate(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_e9a21c1d_c837_4dd0_8fa6_a8b0a93d4528
is: SBO:0000252
has only substance units: false
is: O60427
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3992
name: FADS1
constant: false
type: Species

metaR THRATB0tc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Threonine into the intestinal cells by ATB0 transporter
type: Reaction

metaR AHEXASEly
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_1d741937_8900_45e5_bdcc_f03cf7279e91
is encoded by: hsa:H17063
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: _H17063_1_m
initial amount: NaN
constant: false
has only substance units: false

metaM xol7ah3 c
initial concentration: 1.0
is: CHEBI:28540
constant: false
initial amount: NaN
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: HMDB12455
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,26-triol
boundary condition: false
has only substance units: false
type: Species

metaR RE0935E
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: RE0935
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110010#
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110010#

metaM occoa c
is: HMDB01070
is: CHEBI:57386
type: Species
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
constant: false
initial concentration: 1.0
is: C01944

http://identifiers.org/biomodels.db/MODEL1310110010#_fd6bb671_e145_4523_bab7_c92ae5d83b9b
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: _AA629629_1_m
is: SBO:0000252
is encoded by: hsa:AA629629
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_27b07b2b_99aa_46d3_a8f8_645a4a28407e
is encoded by: hsa:30
name: ACAA1
initial concentration: NaN
is: Q96CA6
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaM glyclt x
type: Species
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
constant: false
has only substance units: false
is: HMDB00115
initial amount: NaN
is: SBO:0000247
name: glycolate
is: CHEBI:29805
boundary condition: false
initial concentration: 1.0

metaR r1580
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction

metaM ppi n
is: HMDB00250
name: diphosphate(3-)
constant: false
is: CHEBI:33019
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species

metaR LEUKTRE4t
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110010#
fast: false
reversible: true
kinetic law: MODEL1310110010#
is: SBO:0000185
name: leukotriene E4 transport
is described by: ECO:0000000

metaM ksi pre31 g
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
initial amount: NaN
is: C00130
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 31
boundary condition: false
is: CHEBI:58053
is: HMDB00175

metaM dopasf e
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: HMDB06275
type: Species
initial concentration: 1.0
is: CHEBI:37946
has only substance units: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
name: dopamine 3-O-sulfate

metaM digalsgalside hs e
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/8384
name: Digalactosylceramidesulfate
has only substance units: false
is: C06127
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
type: Species

metaR SPC HSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
fast: false
type: Reaction
name: sphingosylphosphorylcholine transport (diffusion)
reactant: MODEL1310110010#
reversible: true
is: SBO:0000185

metaM cys L c
is: SBO:0000247
initial amount: NaN
name: L-cysteine
initial concentration: 1.0
constant: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
type: Species
is: CHEBI:17561
has only substance units: false
boundary condition: false
is: HMDB00574

http://identifiers.org/biomodels.db/MODEL1310110010#_3b59672e_3685_448f_939d_da769f656703
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2880
name: GPX5
is: O75715
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR FAS160COA
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
name: fatty-acyl-CoA synthase (n-C16:0CoA)
is described by: ECO:0000269
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_55542907_da45_4777_aa64_f63016df808f
has only substance units: false
is encoded by: hsa:29926
boundary condition: true
is: Q96IJ6
type: Species
constant: false
name: GMPPA
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_3d2f88d2_362c_415f_8b96_76f2aa1d770f
boundary condition: true
is: SBO:0000252
name: _M68895_1_c
constant: false
initial concentration: NaN
is encoded by: hsa:M68895
initial amount: NaN
type: Species
has only substance units: false

metaR r0946
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
product: MODEL1310110010#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NOt
fast: false
is described by: ECO:0000000
reversible: true
name: NO transport (diffusion)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
type: Reaction
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaM so3 c
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
initial concentration: 1.0
is: C00094
has only substance units: false
is: CHEBI:17137
constant: false
is: HMDB00240
name: Sulfite
boundary condition: false

metaM mpdol U c
type: Species
has only substance units: false
initial amount: NaN
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
constant: false
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
is: SBO:0000247
boundary condition: false
is: CHEBI:18396

metaR DGK1
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
type: Reaction
product: MODEL1310110010#
is: SBO:0000176
reversible: true
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110010#
name: deoxyguanylate kinase (dGMP:ATP)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_589c7595_4d0e_4cc9_b1d4_e5bbe0b82a6c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
name: _AA081045_1_c
is encoded by: hsa:AA081045

http://identifiers.org/biomodels.db/MODEL1310110010#_f1ad5391_f1ef_4e32_9524_0f7cd00744d7
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:6799
constant: false
name: SULT1A2
is: SBO:0000252
has only substance units: false
type: Species

metaM gln L m
initial concentration: 1.0
is: CHEBI:18050
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
type: Species
name: L-glutamine
is: SBO:0000247

metaM pyr m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: http://identifiers.org/pubchem.compound/3324
constant: false
is: CHEBI:15361
boundary condition: false
is: HMDB00243
name: pyruvate
is: SBO:0000247
type: Species
is: C00022
initial amount: NaN

metaM galgbside hs g
name: galactosylgloboside
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
initial amount: NaN
has only substance units: false
is: CHEBI:18259
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_49b90f37_c34c_4ab7_a5bb_a0329761b11d
boundary condition: true
is: B3KXN9
is encoded by: hsa:84890
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: ADO
constant: false
has only substance units: false

metaR AHCYSte
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110010#
is described by: ECO:0000134
type: Reaction
name: Transport of S-adenosyl-L-homocysteine
product: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM ppi m
name: Diphosphate
is: C00013
type: Species
is: HMDB00250
boundary condition: false
is: CHEBI:33019
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_06c70c49_3664_4625_85c8_ee46a3e26cd8
is: P50747
boundary condition: true
is encoded by: hsa:3141
has only substance units: false
initial concentration: NaN
constant: false
name: HLCS
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_d1aa2821_bc9c_4346_ba6f_ae6763d02b07
is: SBO:0000252
name: LDHAL6B
constant: false
type: Species
is: Q9BYZ2
boundary condition: true
initial amount: NaN
is encoded by: hsa:92483
has only substance units: false
initial concentration: NaN

metaM Rtotal3coa c
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: HMDB01448
is: CHEBI:16189
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
name: R total 3 Coenzyme A
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ac3799af_5eb8_484a_b166_dd55faabbe3c
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9HBU6
name: ETNK1
initial amount: NaN
constant: false
is encoded by: hsa:55500
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_2f6952c4_d97c_49f8_b638_382f2aefe924
initial concentration: NaN
constant: false
has part: E9PB82
type: Species
boundary condition: true
is: SBO:0000297
name: ACAA1:HSD17B4:ACOX1
initial amount: NaN
is encoded by: hsa:3295
has only substance units: false

metaM n2m2nmasn l
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false
initial concentration: 1.0
is: C04946
type: Species
constant: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR r0801
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
reversible: true
is: SBO:0000185
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
product: MODEL1310110010#

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR GGH 10FTHF6GLUe
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110010#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
is: SBO:0000176
reversible: false
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_05948048_8983_4472_af1f_be814d4767e9
name: MAOB
initial concentration: NaN
is: P27338
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4129
type: Species

metaM dtmp m
name: dTMP
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
type: Species
is: HMDB01227
is: SBO:0000247
is: C00364
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:26999
initial concentration: 1.0

metaR DOLP Uter
reversible: false
product: MODEL1310110010#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: dolichol phosphate flippase (uterus)

metaM adp c
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:16761
boundary condition: false
is: C00008
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: ADP
is: HMDB01341

http://identifiers.org/biomodels.db/MODEL1310110010#_11775f7c_2ec9_4a27_88d0_0c0eae9bcc8c
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2530
boundary condition: true
is: G3V5N0
name: FUT8

metaR MANtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: mannose efflux from Golgi apparatus
fast: false
reversible: false
reactant: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR DNDPt27m
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
product: MODEL1310110010#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110010#
name: dCDP transport via dTDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reactant: MODEL1310110010#

metaM dc2coa m
is: CHEBI:61406
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
initial amount: NaN
name: trans-Dec-2-enoyl-CoA

metaM vitd3 m
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1 EHMN_ABBREVIATION: C05443
initial concentration: 1.0
is: HMDB00876
is: SBO:0000247
is: CHEBI:28940
name: calciol
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR FAOXC1811603m
reversible: false
is: SBO:0000176
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000269
name: Beta oxidation fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_93cf1411_506d_40e9_a42b_2684d182dc91
is encoded by: hsa:5476
is: SBO:0000252
is: P10619
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: CTSA
boundary condition: true

metaM CE5854 e
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
boundary condition: false
has only substance units: false
is: HMDB02710
initial amount: NaN
initial concentration: 1.0
name: gama-CEHC-glucuronide
is: CHEBI:27485
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_ec25b739_cae0_4be1_8fb1_e237415b44a7
is encoded by: hsa:3032
constant: false
is: P55084
type: Species
has only substance units: false
name: HADHB
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r0944
kinetic law: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
name: Active transport

metaR ALAt2r
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
product: MODEL1310110010#
name: L-alanine reversible transport via proton symport

metaM cys L e
has only substance units: false
is: SBO:0000247
name: L-cysteine
boundary condition: false
constant: false
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial concentration: 1.0
is: CHEBI:17561
is: HMDB00574
initial amount: NaN

metaR NACHEXA13ly
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
type: Reaction
product: MODEL1310110010#

metaR ACHtn
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
fast: false
product: MODEL1310110010#
name: Acetylcholin transport, nuclear trhough pores

http://identifiers.org/biomodels.db/MODEL1310110010#_d7ddb827_435b_4cf9_a365_6bcf6b4df39b
is encoded by: hsa:AI915649
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _AI915649_1_c
constant: false
is: SBO:0000252
initial amount: NaN

metaR AG13T10g
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_21e4aaf0_5c46_42f6_bdaf_457d3c8ce89a
initial concentration: NaN
constant: false
name: MAN2A1
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4124
type: Species
initial amount: NaN
is: Q16706

metaR RE1525M
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110010#
is: SBO:0000176
name: RE1525
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_7355a6e7_aceb_49b4_a1e7_016e64b5ab1b
has only substance units: false
name: IK
is: Q13123
initial concentration: NaN
is encoded by: hsa:3550
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_29818fe0_9c1e_4437_898f_69dbba747a87
is: SBO:0000252
is encoded by: hsa:4668
initial amount: NaN
has only substance units: false
name: NAGA
is: P17050
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaM HC01406 m
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
is: CHEBI:28264
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: 3-Oxooctanoyl-CoA
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_abf41b12_ee59_407f_a942_dcbb0eaf4e02
initial amount: NaN
boundary condition: true
is: Q6IBE6
is encoded by: hsa:6484
constant: false
name: ST3GAL4
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_51c3d28b_8a44_436e_ba13_6e29e8c1865b
has only substance units: false
is encoded by: hsa:7054
is: P78428
constant: false
initial amount: NaN
name: TH
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM dolmanp U c
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:15809
boundary condition: false
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110010#_0413be5c_0848_432b_a05c_14c44d5b2a0e
type: Species
is encoded by: hsa:125061
initial amount: NaN
name: AFMID
is: Q63HM1
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM val L e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: L-valine
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
is: CHEBI:16414
is: HMDB00883

metaR ASCBt4
reversible: true
modifier: MODEL1310110010#
type: Reaction
name: L-ascorbate transport via proton symport
is described by: ECO:0000269
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
product: MODEL1310110010#

metaR APAT2rm
is described by: ECO:0000212
reactant: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.6.1.19
type: Reaction
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reversible: true

metaM ppi r
type: Species
constant: false
is: HMDB00250
name: Diphosphate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
is: C00013
is: CHEBI:33019
boundary condition: false

metaR UMPK2n
modifier: MODEL1310110010#
name: UMP kinase (CTP),nuclear
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110010#
fast: false
reversible: true
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM creat e
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
name: creatine
boundary condition: false
is: CHEBI:16919
type: Species
is: HMDB00064
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_3bf51e67_2cfc_4c7d_a7a5_f86b3037eb00
name: GGT1
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P19440
type: Species
is encoded by: hsa:2678

http://identifiers.org/biomodels.db/MODEL1310110010#_b8e89183_2215_4e7f_bb9f_0062c0a49358
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:5723
has only substance units: false
is: P78330
name: PSPH

metaR CHSTEROLtrc
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000185
fast: false
reversible: true
name: transport of cholesterol into the cytosol
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
is described by: ECO:0000134

metaR URIK1
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110010#
product: MODEL1310110010#
name: uridine kinase (ATP:Uridine)
is version of: http://identifiers.org/ec-code/2.7.1.48
type: Reaction
kinetic law: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#

metaR r0870
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.3.4
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.72
product: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/3.6.4.13
name: Facilitated diffusion
modifier: MODEL1310110010#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.6.1.1

http://identifiers.org/biomodels.db/MODEL1310110010#_f2ed7d73_2678_4f87_9c68_4f0661d81cf9
name: ACHE
is encoded by: hsa:43
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR DOLPMT1 Uer
modifier: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.258
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is: SBO:0000176
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false

metaR CYSTLEUrBATtc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_e5f93886_408b_4719_ae0a_53f022ee5828
constant: false
is encoded by: hsa:93034
has only substance units: false
boundary condition: true
name: NT5C1B
is: Q96P26
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

metaR NAHCO3 HCLt
name: bicarbonate transport (HCl/NaHCO3 exchange)
type: Reaction
fast: false
product: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110010#

metaR RE3218C
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.2
product: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
name: RE3218
kinetic law: MODEL1310110010#
is described by: ECO:0000000

metaM biocyt c
boundary condition: false
constant: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: HMDB03134
name: Biocytin
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7886
is: C05552
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR DASCBR
modifier: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
name: dehydroascorbate reductase
is version of: http://identifiers.org/ec-code/1.8.4.1
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110010#

metaR GDPtg
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
fast: false
is: SBO:0000185
name: GDP intracellular transport
type: Reaction
product: MODEL1310110010#

metaM HC00460 c
is: SBO:0000247
constant: false
name: 2,5-dihydroxybenzoate
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:58044
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_0c9afed5_5046_413f_919c_c84a2af771fe
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: DEGS1
has only substance units: false
is: O15121
initial amount: NaN
boundary condition: true
is encoded by: hsa:8560

http://identifiers.org/biomodels.db/MODEL1310110010#_ca7fb1c4_7f03_4571_b214_42dd60926f15
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:R06874
name: _R06874_1_r
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN

metaM 3dhguln c
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57655
initial concentration: 1.0
is: HMDB06334
has only substance units: false
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
name: 3-dehydro-L-gulonate

http://identifiers.org/biomodels.db/MODEL1310110010#_ad0f2d1a_42b5_48ac_8df8_a3be423dcd19
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: Q5JAM2
name: ALAS1
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:211

metaM leuktrD4 c
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666
name: Leukotriene D4
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB03080
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR r0942
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
reversible: true
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_ceaed959_17c9_43a1_a9f5_724e59158647
is: P00918
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:760
initial concentration: NaN
has only substance units: false
boundary condition: true
name: CA2
constant: false

metaR HIBDm
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.31
type: Reaction
is described by: ECO:0000269
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM HC01610 e
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: CoproporphyrinogenI
is: CHEBI:28607
boundary condition: false
has only substance units: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768

http://identifiers.org/biomodels.db/MODEL1310110010#_513096a8_5ad9_4643_8356_821a24897d21
constant: false
name: OCRL
type: Species
initial concentration: NaN
has only substance units: false
is: Q01968
is: SBO:0000252
is encoded by: hsa:4952
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_4ebffaf5_9e9b_44a1_b90c_d245cfd70653
has only substance units: false
type: Species
is encoded by: hsa:64077
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: LHPP
is: Q9H008
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_1a62b9ce_586c_4614_a886_322f56fa8125
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:80270
is: Q9H2F3
initial amount: NaN
type: Species
name: HSD3B7
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_db1a36ed_01da_42ac_a389_d0ac79a619b6
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8776
is: Q13613
name: MTMR1
has only substance units: false
type: Species

metaR ORNt4m
is: SBO:0000185
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
name: ornithine mitochondrial transport exchange with citruline
reactant: MODEL1310110010#
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
product: MODEL1310110010#

metaR DCTPtn
reactant: MODEL1310110010#
fast: false
is: SBO:0000185
reversible: true
name: dCTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
type: Reaction

metaR r1847
is described by: ECO:0000000
reversible: false
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_6fc59c51_f892_445b_915c_85aae6e42fd7
type: Species
initial concentration: NaN
boundary condition: true
name: ACADM
is: SBO:0000252
constant: false
is: P11310
is encoded by: hsa:34
has only substance units: false
initial amount: NaN

metaM val L c
has only substance units: false
is: HMDB00883
initial concentration: 1.0
name: L-valine
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
is: CHEBI:16414

metaR r0719
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6697.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110010#
fast: false
reversible: false
kinetic law: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.153
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
product: MODEL1310110010#
reactant: MODEL1310110010#

metaR r0009
reactant: MODEL1310110010#
is described by: ECO:0000000
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reversible: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.6.1.1
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_289b05a3_17f8_45bf_9450_2f1127774dfa
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:284111
is: Q86YT5
type: Species
is: SBO:0000252
name: SLC13A5

metaR HISD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.3.1.3
reactant: MODEL1310110010#
type: Reaction
name: histidase
reversible: false
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is: SBO:0000176
modifier: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaM gly m
is: C00037
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00123
is: CHEBI:15428
constant: false
is: SBO:0000247
name: Glycine
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037

metaR FUCACGALFUCGALACGLCGALGLUSIDEte
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
name: blood group intracellular transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
product: MODEL1310110010#

metaM tcynt m
has only substance units: false
name: thiocyanate
type: Species
boundary condition: false
is: CHEBI:18022
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

metaR ACt2r
name: acetate reversible transport via proton symport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD

metaR CH25H
name: cholesterol 25-hydroxylase
reversible: false
fast: false
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.14.99.38
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_309432e0_5a08_42e0_a7ec_54d6e5aea6d5
is encoded by: hsa:3939
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P00338
type: Species
has only substance units: false
is: SBO:0000252
name: LDHA

metaM s7p c
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: HMDB01068
is: C05382
is: CHEBI:57483
name: Sedoheptulose 7-phosphate
is: SBO:0000247
initial concentration: 1.0

metaR FK
modifier: MODEL1310110010#
name: Fucokinase
is version of: http://identifiers.org/ec-code/2.7.1.52
kinetic law: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_df496a83_e936_4c12_b6f6_52700e4a6854
boundary condition: true
is encoded by: hsa:27124
initial concentration: NaN
initial amount: NaN
type: Species
name: INPP5J
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_94d63b98_eceb_4557_b9b5_1469c071294e
initial concentration: NaN
is encoded by: hsa:219
type: Species
boundary condition: true
has only substance units: false
is: P30837
constant: false
initial amount: NaN
is: SBO:0000252
name: ALDH1B1

metaM gly c
is: SBO:0000247
boundary condition: false
is: CHEBI:3339
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0
type: Species
is: C00037
has only substance units: false
constant: false
is: HMDB00123
initial amount: NaN
name: Glycine

metaR ACACT5p
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
modifier: MODEL1310110010#
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
fast: false
is: SBO:0000176
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000269

metaR r0570
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/6.3.3.2
product: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is: SBO:0000176

metaR r0683
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110010#
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_91231982_26a7_4472_a08e_8c3c5f2c8724
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4716
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: A8K761
name: NDUFB10
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_c43428d4_eb65_4432_8790_b1a3f7841ed2
boundary condition: true
initial amount: NaN
has only substance units: false
is: P41247
type: Species
constant: false
name: PNPLA4
is encoded by: hsa:8228
initial concentration: NaN
is: SBO:0000252

metaM udpglcur c
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58052
boundary condition: false
name: UDP-D-glucuronate
is: C00167
initial concentration: 1.0
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
has only substance units: false
is: HMDB00935
type: Species

metaR FUCACGALFUCGALACGLCGALGLUSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
name: blood group intracellular transport
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
type: Reaction
reversible: true
product: MODEL1310110010#

metaR r0729
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_9718938b_8717_443b_8179_8d02c80ab904
name: SULT1A3
type: Species
is: SBO:0000252
boundary condition: true
is: Q1ET61
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6818

metaR r1576
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_f5c16978_912a_45ff_a40c_083b41ac19fb
is encoded by: hsa:51251
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9H0P0
name: NT5C3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_c8a0f2db_0dea_49b0_a523_8795d4e93aa1
name: CMA1
is: Q4FEB3
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:1215

metaR r1612
kinetic law: MODEL1310110010#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR r0604
modifier: MODEL1310110010#
is: SBO:0000176
fast: false
type: Reaction
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
product: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_7152e762_5123_4fec_be1b_109866b4476d
type: Species
is: SBO:0000252
is: Q9Y666
is encoded by: hsa:10723
has only substance units: false
name: SLC12A7
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaM dtmp c
initial amount: NaN
is: CHEBI:26999
boundary condition: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
constant: false
initial concentration: 1.0
has only substance units: false
is: C00364
is: HMDB01227
is: SBO:0000247
type: Species
name: dTMP

metaM g2m8mpdol U r
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:59093
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
has only substance units: false

metaR ITCOALm
is: SBO:0000176
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.5
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212
fast: false
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true

metaM 4nphsf e
initial amount: NaN
boundary condition: false
is: CHEBI:35422
is: HMDB06492
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
type: Species
constant: false
name: 4-Nitrophenyl sulfate

metaR HMGCOASim
fast: false
kinetic law: MODEL1310110010#
name: Hydroxymethylglutaryl CoA synthase (ir)
product: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.3.10
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110010#
is: SBO:0000176

metaM 3hpp m
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: HMDB00700
name: 3-hydroxypropionate
is: CHEBI:16510
boundary condition: false
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_c1e6d95f_5719_4587_86b1_62d9287cf600
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:2523
name: FUT1
type: Species
constant: false
has only substance units: false
is: Q6IZA2

metaR r1575
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM lnlc e
is: HMDB00673
initial amount: NaN
is: SBO:0000247
name: linoleate
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial concentration: 1.0
constant: false
is: CHEBI:30245

metaM cmp c
name: CMP
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: C00055
boundary condition: false
constant: false
is: HMDB00095
initial concentration: 1.0
has only substance units: false
is: CHEBI:60377
initial amount: NaN

metaM co2 c
type: Species
is: SBO:0000247
name: CO2
is: C00011
boundary condition: false
constant: false
notes: FORMULA: CO2 CHARGE: 0
is: CHEBI:3313
is: HMDB01967
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM occoa m
initial amount: NaN
is: SBO:0000247
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
constant: false
is: CHEBI:57386
boundary condition: false
is: C01944

metaR r1613
modifier: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
type: Reaction
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1574
kinetic law: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185

metaR ACNAMlt
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110010#
name: N-acetylneuraminate transport into lysososme
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_bca61439_1d2b_42bf_b7ad_a568027e9b4b
constant: false
has only substance units: false
boundary condition: true
type: Species
name: GALNT2
initial amount: NaN
is encoded by: hsa:2590
is: Q10471
is: SBO:0000252
initial concentration: NaN

metaM his L m
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00177
initial concentration: 1.0
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
boundary condition: false
constant: false

metaR r2521
is described by: ECO:0000000
name: Utilized transport
fast: false
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reactant: MODEL1310110010#

metaR DGAT
name: diacylglycerol acyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.20
reactant: MODEL1310110010#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_6d63f0c8_a505_4530_a587_c5098b782eda
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:314
boundary condition: true
type: Species
name: AOC2
initial concentration: NaN
is: SBO:0000252

metaR UMPK3n
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (UTP),nuclear
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110010#
modifier: MODEL1310110010#
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110010#

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR RE3244R
name: RE3244
product: MODEL1310110010#
is: SBO:0000176
reversible: true
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_4bd62103_72fe_45fd_a907_3a0433bfe296
initial concentration: NaN
boundary condition: true
is encoded by: hsa:27034
type: Species
name: ACAD8
constant: false
is: Q6ZWP6
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR TYR3MO2
product: MODEL1310110010#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.14.16.2
name: tyrosine 3-monooxygenase
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7054.1) or (7054.3) or (7054.2) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.16.2 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9920892 NOTES:SAB unlumped form based on PMID 10727395
fast: false
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_63f99e89_a168_4ea0_a74c_32d4545e3aa2
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:1119
name: CHKA
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: P35790

http://identifiers.org/biomodels.db/MODEL1310110010#_b493bd43_beb9_47a6_a748_09b245b0318b
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: VNN3
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:55350

http://identifiers.org/biomodels.db/MODEL1310110010#_594ad838_15b5_4489_a3fe_a9f7b53db1e3
boundary condition: true
is encoded by: hsa:65010
type: Species
name: SLC26A6
is: Q9Y3Y1
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR ARACHCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
name: carnitine transferase
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110010#
reversible: false

metaM btamp c
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: HMDB04220
is: CHEBI:3110
name: Biotinyl-5'-AMP
is: SBO:0000247
boundary condition: false

metaR CITtbm
fast: false
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
name: citrate transport, mitochondrial
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110010#
is described by: ECO:0000269

metaM dtmp e
initial amount: NaN
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0
is: HMDB01227
boundary condition: false
is: SBO:0000247
is: CHEBI:26999
has only substance units: false
name: dTMP(2-)
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ca2a278e_41fe_4596_a96f_93f0e74ee0a2
boundary condition: true
name: PLCB1
is encoded by: hsa:23236
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaR r0727
is: SBO:0000176
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
is described by: ECO:0000000
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction
kinetic law: MODEL1310110010#
reversible: false
product: MODEL1310110010#

metaM pristcoa c
boundary condition: false
is: CHEBI:51341
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
name: pristanoyl coa
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_fb8132d5_3455_4740_b47a_29a21e7f0949
name: GMPPB
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:29925
type: Species

metaM udpg r
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
boundary condition: false
is: SBO:0000247
is: CHEBI:58367
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
constant: false
type: Species
is: HMDB00286

metaR TAURCHAe
is described by: ECO:0000134
reactant: MODEL1310110010#
type: Reaction
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: exit of taurine from the enterocytes
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES:taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.

metaR PAPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110010#
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
name: adenosine 3',5'-bisphosphate Golgi transport
reversible: false
type: Reaction
kinetic law: MODEL1310110010#

metaR r1610
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
fast: false
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_80408524_263e_4096_806e_a5347e01d744
initial concentration: NaN
is encoded by: hsa:29926
boundary condition: true
initial amount: NaN
name: GMPPA
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaR r1573
reversible: true
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_2cb28d19_b081_4668_8f04_9e1c0ff54a0f
is: C9JC79
is encoded by: hsa:6342
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: SCP2
has only substance units: false
constant: false
initial amount: NaN

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_d91785b4_255c_4a09_a3d4_816efd93b9e3
has only substance units: false
name: SLC25A15
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q9Y619
boundary condition: true
is encoded by: hsa:10166
constant: false

metaM HC01414 x
name: trans-dec-2-enoyl-CoA(4-)
is: CHEBI:61406
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h10-11,18-20,24-26,30,41-42H,4-9,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b11-10+/t20-,24-,25-,26+,30-/m1/s1 EHMN_ABBREVIATION: C05275
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_5f09ba3a_3374_489a_8d5f_594b2d62e959
constant: false
is: SBO:0000297
has only substance units: false
type: Species
name: VNN3:VNN2:VNN1
initial amount: NaN
is encoded by: hsa:55350
boundary condition: true
initial concentration: NaN

metaM 4nphsf c
boundary condition: false
is: CHEBI:35422
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06492
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: SBO:0000247
type: Species
name: 4-Nitrophenyl sulfate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_b625b2be_a648_41f2_8e33_9e8f12bb7bf3
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:80339
is: SBO:0000252
is: Q9NST1
initial concentration: NaN
type: Species
name: PNPLA3

metaM pmtcoa r
constant: false
is: C00154
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01338
is: CHEBI:3454
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_8ebb1bcc_fa38_407e_8c2b_2371671d50e7
is: Q13907
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: IDI1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3422
constant: false

metaM s2l2fn2m2masn e
initial amount: NaN
is: CHEBI:3554
is: C00255
boundary condition: false
constant: false
has only substance units: false
name: PA6
initial concentration: 1.0
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: SBO:0000247
type: Species
is: HMDB00244

metaR r0571
fast: false
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
type: Reaction
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
is version of: http://identifiers.org/ec-code/1.5.1.8
modifier: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110010#

metaR FAOXC160
is: SBO:0000176
reactant: MODEL1310110010#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110010#
name: Beta oxidation of long chain fatty acid
type: Reaction
kinetic law: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110010#_6f4c8220_9dfc_4ac5_b010_ee849e9ea40c
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:W87865
type: Species
has only substance units: false
initial concentration: NaN
name: _W87865_1_c

http://identifiers.org/biomodels.db/MODEL1310110010#_6c926576_a5f8_4807_a843_a8cd7840c8ef
is: P13686
is encoded by: hsa:54
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ACP5
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaR ARACHCPT1
type: Reaction
name: carnitine transferase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110010#
reactant: MODEL1310110010#

metaR r0603
reactant: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.12
reversible: true
product: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaR RE2799C
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
reactant: MODEL1310110010#
name: RE2799
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
fast: false
reversible: true

metaR FATP2t
is described by: ECO:0000269
modifier: MODEL1310110010#
fast: false
name: fatty acid electroneutral transport
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000185

metaR r0728
is described by: ECO:0000000
product: MODEL1310110010#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110010#
fast: false
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_9666cfef_af49_47f3_8aff_190a94fd7fdf
is: SBO:0000252
type: Species
is encoded by: hsa:4645
initial concentration: NaN
is: Q9H6Y6
initial amount: NaN
name: MYO5B
constant: false
has only substance units: false
boundary condition: true

metaM din c
has only substance units: false
is: SBO:0000247
name: Deoxyinosine
boundary condition: false
initial concentration: 1.0
is: CHEBI:28997
initial amount: NaN
is: C05512
constant: false
type: Species
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: HMDB00071

metaR r1611
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
fast: false
product: MODEL1310110010#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM lnlc c
is: CHEBI:30245
constant: false
is: HMDB00673
initial amount: NaN
name: linoleate
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_5ca002e9_d26a_4239_829f_156e2108424e
constant: false
name: GALNTL2
is encoded by: hsa:117248
type: Species
boundary condition: true
initial concentration: NaN
is: Q8N3T1
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_8d8e7715_af13_4d5a_9c61_b5cf70f7af54
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is: F8W1L5
name: GPD1
is encoded by: hsa:2819
boundary condition: true

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR ILEt5m
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
name: Isoleucine mitochondrial transport
fast: false
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#

metaM dlnlcgcoa c
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:27979
initial amount: NaN
type: Species

metaM kynate c
name: kynurenate
type: Species
is: SBO:0000247
is: HMDB00715
initial amount: NaN
is: CHEBI:58454
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0

metaR S6T1g
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction

metaM 1pyr5c m
name: 1-Pyrroline-5-carboxylate
is: C03912
is: SBO:0000247
boundary condition: false
is: CHEBI:15893
type: Species
is: HMDB01301
has only substance units: false
constant: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial concentration: 1.0
initial amount: NaN

metaR UGALNACtg
fast: false
name: UDP-GalNAc Golgi transport via CMP antiport
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
type: Reaction
modifier: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD

metaR EX hyptaur LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hypotaurine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_567610a3_b0cc_457c_b29e_0cae86afe3d7
is: Q9UMR5
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: PPT2
is encoded by: hsa:9374

metaM apoC c
notes: FORMULA: XH CHARGE: 0
is: CHEBI:33190
has only substance units: false
type: Species
initial amount: NaN
name: Apocarboxlase (no lys residue)
is: HMDB11111
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM pect e
notes: FORMULA: C2535H3509O2535 CHARGE: -1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
name: pectins
boundary condition: false
is: HMDB03402
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_d017bb77_362d_4bfc_a706_0fb2fd7180d9
is: O95992
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9023
has only substance units: false
name: CH25H
constant: false

metaR r1616
product: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_513eb872_258b_4772_a1a6_ba28f0eeaedc
is: SBO:0000252
name: ADSL
has only substance units: false
initial concentration: NaN
is encoded by: hsa:158
type: Species
boundary condition: true
initial amount: NaN
constant: false

metaR RETI2
name: retinol isomerase (9-cis)
kinetic law: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110010#

metaR NBAHH ir
reversible: false
is version of: http://identifiers.org/ec-code/3.4.13.20
notes: GENE_ASSOCIATION: (84735.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 3.4.13.3 Confidence Level: 1 AUTHORS: PMID:4026801 NOTES:NAME Nalpha-(beta-alanyl)-L-histidine hydrolase DEFINITION Carnosine + H2O <=> beta-Alanine + L-Histidine SAB made irreversible for human
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000134
fast: false
type: Reaction
is: SBO:0000176

metaM CE0849 m
boundary condition: false
name: cis,cis-palmito-7,10-dienoyl-CoA
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: C01936
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849

http://identifiers.org/biomodels.db/MODEL1310110010#_4ed7e880_d096_410e_9792_8d4fa457e421
constant: false
is encoded by: hsa:AA278423
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _AA278423_1_c

metaM dcdp m
is: SBO:0000247
initial concentration: 1.0
is: HMDB01245
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:58593
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP(3-)

metaR SGPL12r
type: Reaction
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
is version of: http://identifiers.org/ec-code/4.1.2.27
is: SBO:0000176
name: Sphingosine-1-phosphate lyase
reversible: false

metaM ump n
constant: false
has only substance units: false
boundary condition: false
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57865
is: SBO:0000247
is: HMDB00288
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_43749222_8947_413b_b1ba_067d66afa3ee
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _BG035985_1_c
is encoded by: hsa:BG035985
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_5c093ec5_293b_4cff_817a_a5cb2171b6d8
initial concentration: NaN
is: Q06136
name: KDSR
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:2531
boundary condition: true

metaM dpcoa m
name: 3'-dephospho-CoA(2-)
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
constant: false
is: HMDB01373
is: CHEBI:57328
has only substance units: false

metaR r1571
reversible: true
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
is: SBO:0000185

metaM 4abut m
boundary condition: false
has only substance units: false
is: HMDB00112
constant: false
name: 4-Aminobutanoate
is: SBO:0000247
is: C00334
is: CHEBI:16865
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
type: Species

metaM his L e
constant: false
is: HMDB00177
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
boundary condition: false
initial concentration: 1.0
is: CHEBI:15971
type: Species
name: L-histidine
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_2412e39f_4794_4bd5_8623_d0303fa8363d
has only substance units: false
is: Q14032
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: BAAT
is encoded by: hsa:570

metaR r0726
is described by: ECO:0000000
product: MODEL1310110010#
reversible: true
type: Reaction
modifier: MODEL1310110010#
reactant: MODEL1310110010#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR r2100
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
kinetic law: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000000

metaM so3 m
boundary condition: false
name: hydrogensulfite
type: Species
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: HMDB00240
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17137
constant: false
is: SBO:0000247
has only substance units: false

metaM biocyt m
is: http://identifiers.org/pubchem.compound/7886
type: Species
name: Biocytin
is: HMDB03134
boundary condition: false
is: SBO:0000247
is: C05552
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_651d2e6a_d9f3_4bea_8aa2_f24566d55bc8
has only substance units: false
is encoded by: hsa:2348
constant: false
name: FOLR1
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM man l
is: HMDB00169
initial amount: NaN
is: CHEBI:16024
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: D-mannose
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

metaR r1617
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_b1675031_756c_4e61_8d5e_d64e6a38179f
type: Species
initial concentration: NaN
is: Q9UIG8
boundary condition: true
is: SBO:0000252
name: SLCO3A1
is encoded by: hsa:28232
constant: false
has only substance units: false
initial amount: NaN

metaR S6T13g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110010#
reversible: false
kinetic law: MODEL1310110010#
is: SBO:0000176

metaR r0686
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reversible: true
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is version of: http://identifiers.org/ec-code/2.3.2.2

metaR PTRCOX1
modifier: MODEL1310110010#
reversible: false
name: Putrescine:oxygen oxidoreductase (deaminating)
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.21
is: SBO:0000176
is described by: ECO:0000304

metaM dcdp n
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58593
initial concentration: 1.0
is: HMDB01245
type: Species
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP(3-)
boundary condition: false
is: SBO:0000247

metaM core6 g
constant: false
boundary condition: false
type: Species
name: Core 6
has only substance units: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16478

metaM m4mpdol U c
initial concentration: 1.0
has only substance units: false
is: CHEBI:37633
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247

metaR r2525
product: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110010#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000

metaR C3STKR2r
modifier: MODEL1310110010#
fast: false
is: SBO:0000176
product: MODEL1310110010#
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110010#
name: C-3 sterol keto reductase (zymosterol)
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_533eb987_417b_4c8f_88c2_d1ee7f8ae523
boundary condition: true
initial concentration: NaN
name: SCD
is: O00767
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6319
constant: false
type: Species
initial amount: NaN

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_0f5af93b_a0ea_4612_a04e_5082561029a5
is encoded by: hsa:6716
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: P31213
is: SBO:0000252
has only substance units: false
name: SRD5A2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_b4b1111f_bc26_445d_ae4e_b9db2694bda8
type: Species
name: ACOT1
is: SBO:0000252
is encoded by: hsa:641371
has only substance units: false
boundary condition: true
is: E9KL42
initial amount: NaN
initial concentration: NaN
constant: false

metaR r1614
reversible: true
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaM ksi deg3 l
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 3
has only substance units: false
is: HMDB01356
type: Species
is: CHEBI:57312
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR r0937
name: Transport reaction
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_6d970442_abc1_4a82_af25_86d66890d0ea
is encoded by: hsa:4715
constant: false
has only substance units: false
is: Q9Y6M9
name: NDUFB9
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaM oxa m
type: Species
is: HMDB02329
constant: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
name: oxalate(2-)
has only substance units: false
initial amount: NaN
is: CHEBI:30623
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM gly e
is: C00037
is: CHEBI:3339
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0
is: HMDB00123
name: Glycine
has only substance units: false

metaR S6T9g
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#

metaM glac c
is: SBO:0000247
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
initial amount: NaN
type: Species
constant: false
name: D-glucurono-6,3-lactone
boundary condition: false
is: CHEBI:18268
is: HMDB06355
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_d3c0e4fb_2f64_4236_a6eb_574a8f197aef
boundary condition: true
name: LPL
initial amount: NaN
is encoded by: hsa:4023
constant: false
is: SBO:0000252
has only substance units: false
is: P06858
type: Species
initial concentration: NaN

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_9b5d0896_9946_4f3d_9278_df36685aff08
initial amount: NaN
has part: Q9NS82
boundary condition: true
is encoded by: hsa:56301
is encoded by: hsa:6520
constant: false
initial concentration: NaN
type: Species
is: SBO:0000297
has only substance units: false
has part: P08195
name: SLC7A10:SLC3A2

metaM ump r
is: CHEBI:57865
name: UMP
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

metaR r0723
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
reversible: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110010#
type: Reaction
fast: false

metaM ctp n
constant: false
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
is: HMDB00082
is: SBO:0000247
type: Species
boundary condition: false
name: CTP(4-)
has only substance units: false
is: CHEBI:37563

metaM C04849 e
initial amount: NaN
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:57449
initial concentration: 1.0
constant: false
type: Species

metaR NADPHtxu
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
fast: false
name: NADPH transporter, peroxisome
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR r2526
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_4c5eb922_40fe_4839_b5fe_59e5e8db3b3f
initial amount: NaN
type: Species
has only substance units: false
name: LYZL1
is: Q6UWQ5
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:84569
constant: false

metaM mi14p c
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
boundary condition: false
is: HMDB00968
type: Species
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
initial concentration: 1.0
is: CHEBI:58282
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_11c6785c_2a6b_4b80_b566_58a61bff1607
name: HAS1
initial concentration: NaN
initial amount: NaN
is: Q8IYH3
is encoded by: hsa:3036
is: SBO:0000252
constant: false
boundary condition: true
type: Species
has only substance units: false

metaR NACHEXA18ly
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110010#
is described by: ECO:0000000
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_e05b2e65_ec6a_42b6_92f9_6237b67e0069
is: P30838
is encoded by: hsa:218
type: Species
boundary condition: true
name: ALDH3A1
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_b0b6df74_d2ef_4b9a_bb7a_c6307a532d06
is: SBO:0000252
is encoded by: hsa:AV713053
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AV713053_1_m
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_b3e9aefe_a326_40fb_8b20_0be45a1b7a83
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC5A9
is: E9PAK4
is encoded by: hsa:200010

metaR r1615
is: SBO:0000185
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_f314eed4_bd9f_402e_8c8a_d3ae9cc3b412
is: B4DG68
name: NOS1
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4842
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_94044c55_9255_4db5_88c3_007b0aafe3e6
name: FOLR1
initial concentration: NaN
is encoded by: hsa:2348
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM ksi deg24 l
boundary condition: false
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 24
has only substance units: false
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
constant: false
is: SBO:0000247
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0

metaM tcynt e
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
name: thiocyanate
type: Species
constant: false
is: SBO:0000247
is: CHEBI:18022
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR RETI3
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 4 AUTHORS: PMID:11606944 NOTES:IT
name: retinol isomerase (13-cis)
fast: false
product: MODEL1310110010#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_378b9aa3_eccd_43e0_b552_d596dad5146e
boundary condition: true
initial amount: NaN
is: Q96CA6
name: ACAA1
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:30
constant: false
initial concentration: NaN

metaR r0724
is version of: http://identifiers.org/ec-code/2.7.1.33
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110010#
reversible: true
product: MODEL1310110010#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
reactant: MODEL1310110010#
modifier: MODEL1310110010#

metaR r0688
modifier: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110010#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110010#_1bb1210b_3961_49e2_8e2f_fcfc4c0dc16a
is encoded by: hsa:9963
is: SBO:0000252
type: Species
is: Q9UHI7
initial concentration: NaN
name: SLC23A1
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

metaR PI345P5P
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.3.56
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_77b30005_d709_4990_b35b_41c46d5a9a0a
initial amount: NaN
is encoded by: hsa:6509
has only substance units: false
initial concentration: NaN
name: SLC1A4
type: Species
boundary condition: true
constant: false
is: P43007
is: SBO:0000252

metaM asp L c
boundary condition: false
name: L-aspartate(1-)
initial amount: NaN
is: CHEBI:29991
constant: false
is: HMDB00191
has only substance units: false
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: SBO:0000247
initial concentration: 1.0

metaR r0721
is: SBO:0000176
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110010#

metaR r0578
reactant: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/4.1.2.27
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_d06daab8_674b_465a_9c0d_a3efddd7d3ae
type: Species
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:771
is: SBO:0000252
name: CA12
initial concentration: NaN
is: O43570

metaM galgluside hs g
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: C00015
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
has only substance units: false
is: CHEBI:58223
is: HMDB00295
initial amount: NaN
initial concentration: 1.0

metaM ksi pre24 g
has only substance units: false
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: C00130
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 24
is: HMDB00175
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C191H306N13O158S7X CHARGE: -8

metaM m7mpdol U r
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:37636
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20

metaR ATP2ter
name: AMP/ATP transporter, endoplasmic reticulum
reversible: true
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
type: Reaction

metaM cgly c
constant: false
is: HMDB00078
is: CHEBI:4047
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial concentration: 1.0
name: L-cysteinylglycine
is: SBO:0000247
type: Species

metaM ump c
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
has only substance units: false
is: CHEBI:57865
is: HMDB00288
name: UMP
initial amount: NaN
is: C00105
initial concentration: 1.0
type: Species
constant: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_593c35fc_c85f_4dc5_be72_d96fabf21aad
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7296
constant: false
name: TXNRD1

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM tethex3coa x
is: C16168
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205478
name: tetracosahexaenoyl coenzyme A
is: HMDB06243
type: Species
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
initial amount: NaN

metaM ahcys r
boundary condition: false
constant: false
is: HMDB00939
initial concentration: 1.0
name: S-adenosyl-L-homocysteine
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:16680
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021

http://identifiers.org/biomodels.db/MODEL1310110010#_d1dc2baa_ace2_4275_b845_a5e4f7a9752b
is encoded by: hsa:55350
constant: false
is: SBO:0000297
initial amount: NaN
name: VNN3:VNN2:VNN1
type: Species
initial concentration: NaN
has part: O95498
is encoded by: hsa:8875
has only substance units: false
boundary condition: true

metaM btamp m
is: HMDB04220
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Biotinyl-5'-AMP
is: CHEBI:3110
type: Species
constant: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: SBO:0000247

metaM tcynt c
name: thiocyanate
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18022
type: Species
constant: false
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

metaR r0722
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110010#
type: Reaction
reversible: true
product: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.3.12
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110010#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_1e6b48c1_c03e_4973_8c4e_f59af8ca5ebe
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110010#_ed4140fe_0bb4_4b57_9880_2ee85d608c04
initial amount: NaN
type: Species
is: SBO:0000252
name: _AI222095_1_e
initial concentration: NaN
is encoded by: hsa:AI222095
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_2e8c9f3a_1aab_44b3_b20c_12f93bc7c1ff
boundary condition: true
is encoded by: hsa:4713
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: NDUFB7
initial amount: NaN
type: Species
is: P17568

metaR MANtly
name: mannose efflux from lysosome
reactant: MODEL1310110010#
reversible: false
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction

metaR ALADGLNexR
name: L-alanine/glutamine reversible exchange
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185

metaM glyc m
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17754
is: HMDB00131
is: C00116
boundary condition: false
name: Glycerol
has only substance units: false
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

http://identifiers.org/biomodels.db/MODEL1310110010#_83869cdd_ecb6_492a_86e3_2d6c1c25f61b
is encoded by: hsa:2525
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is: P21217
name: FUT3
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_37565326_59e5_4c48_8b42_86be1f633a3c
is: SBO:0000252
is: Q5JT09
name: UCK1
constant: false
type: Species
is encoded by: hsa:83549
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaR CYSGLUexR
is: SBO:0000185
modifier: MODEL1310110010#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-cysteine/L-glutamine reversible exchanger
type: Reaction
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false

metaM core6 l
name: Core 6
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
has only substance units: false
is: HMDB00143

metaR G14T17g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_73e09833_0da1_42db_849e_cb8c9368949b
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AV717590
is: SBO:0000252
type: Species
name: _AV717590_1_m
constant: false
initial concentration: NaN

metaR HISt4
fast: false
reversible: false
product: MODEL1310110010#
type: Reaction
name: L-histidine transport in via sodium symport
is described by: ECO:0000269
reactant: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (11254.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10930503 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110010#_14251f6b_8b57_4e0c_8569_2e4ac0a60a46
name: _AI697028_1_e
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:AI697028
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_552abe69_4b72_4d30_9c04_5b48c32646d8
is: SBO:0000252
boundary condition: true
is: B3KQ63
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: HPD
is encoded by: hsa:3242
initial amount: NaN

metaR PPItm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
type: Reaction
name: diphopshate transporter, mitochondrial
kinetic law: MODEL1310110010#
reversible: true
is: SBO:0000185
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000134

metaM biocyt n
is: http://identifiers.org/pubchem.compound/7886
type: Species
initial amount: NaN
is: C05552
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: HMDB03134
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

metaM hmgcoa c
initial concentration: 1.0
boundary condition: false
is: HMDB01375
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR r1618
product: MODEL1310110010#
modifier: MODEL1310110010#
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM cgly e
is: CHEBI:4047
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: SBO:0000247
initial concentration: 1.0
name: L-cysteinylglycine
constant: false
is: HMDB00078
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_5bb5dc97_e34c_404c_a941_98b4d8876002
has only substance units: false
initial concentration: NaN
constant: false
is: P48067
name: SLC6A9
initial amount: NaN
is encoded by: hsa:6536
type: Species
boundary condition: true
is: SBO:0000252

metaM man c
type: Species
has only substance units: false
is: C00159
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
is: SBO:0000247
boundary condition: false
is: HMDB00169

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM ump e
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: UMP(2-)
is: HMDB00288
initial amount: NaN
boundary condition: false
is: CHEBI:57865
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR 4NPHte
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
reversible: true
name: xenobiotic transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
reactant: MODEL1310110010#
is: SBO:0000185

metaM s2l2fn2m2masn l
type: Species
initial concentration: 1.0
name: PA6
is: CHEBI:18287
initial amount: NaN
notes: FORMULA: C90H145N6O65X CHARGE: -2
has only substance units: false
boundary condition: false
is: HMDB00174
is: SBO:0000247
constant: false

metaM CE2431 m
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: cis-deca-4-enoyl-CoA
is: C01936
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_2ffe1150_a602_4d2c_9460_626efe893ffd
initial amount: NaN
is encoded by: hsa:6483
is: Q16842
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: ST3GAL2
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_138062ce_9ad6_454a_bfd7_1fab61c4fa45
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: P42765
name: ACAA2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10449

metaR HISSNAT5tc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM cdp c
is: C00112
constant: false
is: HMDB01546
is: SBO:0000247
initial amount: NaN
name: CDP
is: CHEBI:58069
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_6cdd4300_6089_4e1a_a2e0_b56bb8fe3dc7
is: D9HTE9
is: SBO:0000252
initial concentration: NaN
name: SLC25A1
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:6576

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR LGTHL
is version of: http://identifiers.org/ec-code/4.4.1.5
name: lactoylglutathione lyase
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000269
fast: false
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF

http://identifiers.org/biomodels.db/MODEL1310110010#_7f137fbb_45f0_48a6_a01c_b1d0dfc27905
name: NDUFB11
is encoded by: hsa:54539
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: Q9NX14
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM dnad c
is: HMDB01179
constant: false
boundary condition: false
is: C00857
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18304
is: SBO:0000247
type: Species
name: Deamino-NAD+
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
has only substance units: false

metaR r0720
kinetic law: MODEL1310110010#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
is: SBO:0000176

metaR r0579
product: MODEL1310110010#
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
type: Reaction
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.13.11.19
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
reversible: true

metaR RE2996X
reversible: true
name: RE2996
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (26063.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.34
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
fast: false
is: SBO:0000176

metaR r1619
is: SBO:0000185
modifier: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM dlnlcgcoa r
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial concentration: 1.0
constant: false
boundary condition: false
name: dihomo-gamma-linolenyl coenzyme A
has only substance units: false
is: CHEBI:27979
is: SBO:0000247
type: Species
initial amount: NaN
is: C03595

metaM his L c
type: Species
name: L-histidine
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00177
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_b8c41435_3c51_453c_8921_05cc179b3850
initial concentration: NaN
type: Species
is: F5GY65
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8402
name: SLC25A11

metaR RE0452M
kinetic law: MODEL1310110010#
name: RE0452
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
reversible: true
product: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
fast: false

metaM phe L e
is: HMDB00159
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:17295
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
name: L-phenylalanine

http://identifiers.org/biomodels.db/MODEL1310110010#_ab5e1a0e_bf55_42d2_b8bc_bc92aac6521e
is encoded by: hsa:1962
is: Q9NY65
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: EHHADH
boundary condition: true
type: Species

metaR AG13T4g
is: SBO:0000176
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
product: MODEL1310110010#

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_6c7300e1_9052_4431_8cc9_0145283ca6ca
has only substance units: false
name: CA3
type: Species
is: SBO:0000252
boundary condition: true
is: P07451
initial concentration: NaN
is encoded by: hsa:761
initial amount: NaN
constant: false

metaR RE1447N
type: Reaction
is: SBO:0000176
reactant: MODEL1310110010#
name: RE1447
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110010#
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_9dbd5a7b_8ef8_4b26_bc83_32ad4fccae34
type: Species
is: SBO:0000252
is encoded by: hsa:160728
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q8N695
name: SLC5A8
initial concentration: NaN

metaM HC02214 e
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial amount: NaN
is: CHEBI:28852
type: Species
boundary condition: false
name: prostaglandin-f1alpha
is: SBO:0000247

metaR r1467
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
name: Postulated transport reaction

metaM Rtotalcoa c
constant: false
boundary condition: false
is: CHEBI:16189
initial concentration: 1.0
is: HMDB01448
has only substance units: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
type: Species
is: SBO:0000247
name: R total Coenzyme A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_39d2a5a4_0345_4684_aa86_46f013d08b8a
initial amount: NaN
name: SLC6A5
has only substance units: false
constant: false
is encoded by: hsa:9152
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9Y345

metaM dag hs c
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: diglyceride
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:18035

metaM vitd3 c
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: HMDB00876
is: SBO:0000247
is: CHEBI:28940
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: calciol
boundary condition: false

metaR r1154
product: MODEL1310110010#
reversible: true
fast: false
name: EC:1.2.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110010#

metaM dgdp m
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false
name: dGDP(2-)
is: HMDB00960
type: Species
constant: false
boundary condition: false
is: CHEBI:58595
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_677fe888_a13d_417f_9bba_789ae98abec7
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: ACAA2
initial concentration: NaN
is encoded by: hsa:10449
is: P42765
is: SBO:0000252

metaM cdp e
initial amount: NaN
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
name: CDP(3-)
is: HMDB01546

http://identifiers.org/biomodels.db/MODEL1310110010#_acab0569_8722_4e0d_b2c0_6381ec85308f
initial concentration: NaN
constant: false
is encoded by: hsa:221
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P43353
boundary condition: true
name: ALDH3B1
type: Species

metaM occoa x
name: Octanoyl-CoA (n-C8:0CoA)
is: HMDB01070
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:57386
initial concentration: 1.0
type: Species
boundary condition: false
is: C01944

http://identifiers.org/biomodels.db/MODEL1310110010#_a6ab8286_2302_4fe7_975b_603697987874
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is: Q8WUM9
is encoded by: hsa:6574
initial concentration: NaN
initial amount: NaN
constant: false
name: SLC20A1

metaM nm2masn g
notes: FORMULA: C42H70N3O30X CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
constant: false
is: C05884
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR r2308
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110010#

metaM oxa x
name: oxalate(2-)
is: CHEBI:30623
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: HMDB02329

http://identifiers.org/biomodels.db/MODEL1310110010#_2a228d7a_bbea_44f8_b69f_e80844997649
has only substance units: false
type: Species
is: SBO:0000252
name: HLCS
initial amount: NaN
boundary condition: true
is encoded by: hsa:3141
initial concentration: NaN
constant: false
is: P50747

metaM pmtcoa m
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: SBO:0000247
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
initial concentration: 1.0
initial amount: NaN
is: C00154
boundary condition: false
constant: false
is: CHEBI:57379

http://identifiers.org/biomodels.db/MODEL1310110010#_fcef77e7_6cb1_4287_9cec_f6673969cb36
name: STARD3
is: SBO:0000252
is: B4DUY1
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:10948
initial concentration: NaN
constant: false

metaR KSII CORE4t
kinetic law: MODEL1310110010#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core4) transport, golgi to extracellular
is: SBO:0000185
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#

metaM ump g
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
initial amount: NaN
is: HMDB00288
is: CHEBI:57865
name: UMP(2-)

metaM ksi pre9 g
initial concentration: 1.0
type: Species
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 9
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:58053
is: C00130
initial amount: NaN
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
has only substance units: false

metaM din e
has only substance units: false
is: HMDB00071
is: C05512
initial concentration: 1.0
is: CHEBI:28997
name: Deoxyinosine
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
boundary condition: false

metaM cmp g
is: HMDB00095
is: SBO:0000247
is: CHEBI:60377
constant: false
initial amount: NaN
initial concentration: 1.0
name: CMP(2-)
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaR r1466
reversible: true
fast: false
is: SBO:0000176
name: EC:2.3.1.86
type: Reaction
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:

metaR r1579
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR GLYt2r
is described by: ECO:0000304
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
name: glycine reversible transport via proton symport
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: true
fast: false
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD

metaR DRIBt
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
product: MODEL1310110010#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: deoxyribose transport via diffusion
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_442a907d_ae19_4115_b73b_1505a033b13e
boundary condition: true
initial amount: NaN
is: Q53HE2
type: Species
has only substance units: false
is: SBO:0000252
name: TPI1
initial concentration: NaN
is encoded by: hsa:7167
constant: false

metaM forglu c
is: SBO:0000247
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: CHEBI:18327
has only substance units: false
is: HMDB00854
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: C00439
name: N-Formimidoyl-L-glutamate

metaM pyr c
constant: false
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: pyruvate
is: CHEBI:15361
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1
is: SBO:0000247
is: C00022
initial amount: NaN
type: Species

metaR r0573
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:438652 NOTES:
type: Reaction
name: Cholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110010#

metaR G14T5g
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110010#

metaR RE3346M
is: SBO:0000176
modifier: MODEL1310110010#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
name: RE3346
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000000

metaM glutcoa m
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
name: glutaryl-CoA(5-)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01339
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57378

metaM 3otdcoa x
is: CHEBI:28726
constant: false
is: HMDB03935
has only substance units: false
name: 3-Oxotetradecanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
boundary condition: false
initial amount: NaN

metaM dpcoa e
is: HMDB01373
is: CHEBI:57328
is: SBO:0000247
boundary condition: false
name: Dephospho-CoA
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
has only substance units: false
type: Species
is: C00882
initial amount: NaN
initial concentration: 1.0
constant: false

metaR PI45PLC
type: Reaction
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
modifier: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_8abc2a9e_cfa9_4311_8ac3_6d3a83aadbf6
boundary condition: true
name: GLRX
is encoded by: hsa:2745
is: P35754
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR AOBUTDsm
name: L-2-amino-3-oxobutanoate decarboxylation, mitochondrial (spontaneous)
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12097150 NOTES:Spontaneous reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_baf60049_9445_4ff8_b655_0d6b22b908b0
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AD000092_1_c
is encoded by: hsa:AD000092
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaR PRODt2r
modifier: MODEL1310110010#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
reactant: MODEL1310110010#
reversible: true
product: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
name: D-proline reversible transport via proton symport
fast: false

metaM asp L e
has only substance units: false
initial concentration: 1.0
is: CHEBI:29991
is: SBO:0000247
name: L-aspartate(1-)
is: HMDB00191
type: Species
boundary condition: false
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN

metaM HC02214 c
is: CHEBI:28852
name: prostaglandin-f1alpha
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
type: Species
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_d5b539b6_0d44_40f3_9dab_efde948353ae
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84649
is: Q96PD7
name: DGAT2
initial amount: NaN

metaR CITL
is described by: ECO:0000000
product: MODEL1310110010#
is: SBO:0000176
reversible: false
name: Citrate lyase
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR

metaR r1578
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185

metaM 3mob m
type: Species
name: 3-methyl-2-oxobutanoate
is: CHEBI:11851
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00019
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141

metaM man g
is: CHEBI:16024
is: SBO:0000247
type: Species
name: D-mannose
constant: false
boundary condition: false
is: HMDB00169
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

metaR OROTGLUt
fast: false
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: OROTGLUt
reactant: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#

metaR r1156
product: MODEL1310110010#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110010#
type: Reaction
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:

metaR MI134P4P
name: inositol-1,3,4-trisphosphate 4-phosphatase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reactant: MODEL1310110010#
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#

metaR r0321
product: MODEL1310110010#
reversible: false
type: Reaction
is: SBO:0000176
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.5.2
modifier: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:

metaM ru5p D c
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
boundary condition: false
is: HMDB00618
has only substance units: false
name: D-ribulose 5-phosphate(2-)
is: CHEBI:58121
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR PPCOAOm
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is: SBO:0000176
reactant: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110010#

metaR DOPASULT
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
modifier: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
reversible: false
name: Dopamine Sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.1
is described by: ECO:0000269
fast: false

metaR C226COAtx
type: Reaction
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110010#_3c6edb4e_6376_4301_a18d_4f2baf82f92b
name: ITPKA
is encoded by: hsa:3706
has only substance units: false
is: P23677
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_4ba6e382_37cc_4d3f_b3b7_9161973bfee8
has only substance units: false
initial amount: NaN
name: SLC2A13
constant: false
is: SBO:0000252
is encoded by: hsa:114134
initial concentration: NaN
boundary condition: true
is: Q96QE2
type: Species

metaM cmp e
is: HMDB00095
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
constant: false
name: CMP(2-)

metaM co2 e
has only substance units: false
initial concentration: 1.0
is: CHEBI:16526
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
name: CO2
is: SBO:0000247
constant: false
is: HMDB01967

metaM 20ahchsterol m
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06283
type: Species
name: 20-hydroxycholesterol
is: CHEBI:1296
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_87f5c709_e24b_45e9_b346_7ca9b441b5d2
is encoded by: hsa:2678
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: P19440
initial amount: NaN
name: GGT1
type: Species
boundary condition: true

metaR r0575
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
modifier: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:

metaM dgdp n
initial concentration: 1.0
has only substance units: false
name: dGDP(2-)
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
initial amount: NaN
is: HMDB00960
boundary condition: false
is: SBO:0000247
is: CHEBI:58595

metaR BILDGLCURtr
product: MODEL1310110010#
reversible: true
is: SBO:0000185
fast: false
name: glucuronidated compound transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR r0680
type: Reaction
reversible: true
product: MODEL1310110010#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
kinetic law: MODEL1310110010#
is: SBO:0000176
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.137

http://identifiers.org/biomodels.db/MODEL1310110010#_e72ca931_ec5d_4446_92fe_581be2d7424d
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is: P00491
is encoded by: hsa:4860
type: Species
has only substance units: false
name: PNP
boundary condition: true

metaR r1464
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110010#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110010#
type: Reaction
reversible: true
reactant: MODEL1310110010#
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110010#_857a778e_b328_4288_a2cd_3b2231a46e04
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: MYO5B
is encoded by: hsa:4645
constant: false
initial amount: NaN
boundary condition: true
is: Q9H6Y6

metaM lac D c
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
name: (R)-lactate
is: HMDB01311
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16004
initial amount: NaN
constant: false

metaR PMTCOAtx
fast: false
is described by: ECO:0000000
type: Reaction
name: fatty acid intracellular transport
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR CYTK11n
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
name: cytidylate kinase (dCMP,dGTP),nuclear
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reversible: true

metaR CYTK3n
type: Reaction
is: SBO:0000176
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110010#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR VALt4
reversible: false
fast: false
name: L-valine transport in via sodium symport
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reactant: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR r2309
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110010#
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_7691cb5d_84ec_4b99_9200_a7346475af88
initial amount: NaN
boundary condition: true
is encoded by: hsa:2687
has only substance units: false
name: GGT5
is: P36269
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaM spmd e
initial amount: NaN
boundary condition: false
is: CHEBI:57834
name: Spermidine
type: Species
is: C00315
constant: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01257

metaM ppcoa x
is: SBO:0000247
constant: false
name: Propanoyl-CoA
has only substance units: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species
initial amount: NaN
is: C00100
is: CHEBI:57392
boundary condition: false
initial concentration: 1.0
is: HMDB01275

http://identifiers.org/biomodels.db/MODEL1310110010#_e52d945d_4716_4656_9e82_5ff517c6fe1b
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: ADH1B
is encoded by: hsa:125
type: Species
is: P00325
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_73f03173_7054_43ac_a30f_11b8b1fdc904
constant: false
initial amount: NaN
name: GMPR2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51292
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_792b991a_fa23_4f00_b544_8d14c9ff0a57
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6817
initial amount: NaN
is: P50225
constant: false
type: Species
name: SULT1A1
has only substance units: false
initial concentration: NaN

metaR 34HPPOR
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.27
type: Reaction
product: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
reversible: false
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
reactant: MODEL1310110010#

metaR GLCt4
is: SBO:0000185
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
name: glucose transport via sodium symport
product: MODEL1310110010#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_546db330_c2cb_4de8_9220_0125348dace0
is: O15382
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: BCAT2
has only substance units: false
is encoded by: hsa:587

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaM dttp n
type: Species
is: CHEBI:37568
constant: false
has only substance units: false
initial amount: NaN
is: C00459
boundary condition: false
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
name: dTTP
initial concentration: 1.0

metaR GK1
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.8
is: SBO:0000176
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: guanylate kinase (GMP:ATP)
modifier: MODEL1310110010#
fast: false

metaM glyc c
is: SBO:0000247
initial amount: NaN
constant: false
name: Glycerol
is: CHEBI:17754
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00116
is: HMDB00131

http://identifiers.org/biomodels.db/MODEL1310110010#_73627192_ec48_4ff1_8cdb_8a84c75cca9b
is: P23434
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:2653
is: SBO:0000252
name: GCSH
type: Species

metaR DURIPP
reversible: true
type: Reaction
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.2.3
name: deoxyuridine phosphorylase
is: SBO:0000176
product: MODEL1310110010#
is described by: ECO:0000269
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110010#_87d7fbd9_04e9_4409_a267_a9aca647af90
name: _22305_1_c
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:22305
has only substance units: false
type: Species

metaR URIDK2m
reactant: MODEL1310110010#
reversible: true
name: uridylate kinase (dUMP), mitochondrial
fast: false
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT

metaM sph1p c
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
constant: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial amount: NaN
is: CHEBI:57939
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01383
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_64abe5ef_7a9d_4e6e_8f91_010d91e0ce3b
is encoded by: hsa:5337
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: PLD1
initial amount: NaN
has only substance units: false
constant: false
is: Q59EA4

metaR DNDPt9m
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110010#
is described by: ECO:0000269
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
name: dADP transport via dTDP antiport
product: MODEL1310110010#
reversible: false

metaM arachcoa m
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527
initial concentration: 1.0
boundary condition: false
name: arachidyl coenzyme A
is: SBO:0000247
type: Species
is: HMDB04258
has only substance units: false
constant: false
initial amount: NaN

metaM HC01405 m
has only substance units: false
is: CHEBI:28632
constant: false
initial concentration: 1.0
name: (S)-Hydroxyoctanoyl-CoA
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266

metaR TETPENT6COAtx
kinetic law: MODEL1310110010#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
is: SBO:0000185
product: MODEL1310110010#
reactant: MODEL1310110010#

metaM pe hs r
initial amount: NaN
has only substance units: false
constant: false
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:16038
initial concentration: 1.0
type: Species
boundary condition: false

metaR CARPEPT1tc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Carnosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_68144f26_3a33_4c0c_92c8_4d1cd2dfd4bd
is encoded by: hsa:AA177072
name: _AA177072_1_c
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR BTNPL
is: SBO:0000176
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
type: Reaction
name: holocarboxylase synthestase (biotin protein ligase)
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false

metaM dttp m
constant: false
is: HMDB01342
initial amount: NaN
is: CHEBI:37568
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: dTTP
initial concentration: 1.0
is: C00459

metaM spmd c
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
initial amount: NaN
is: C00315
name: Spermidine
is: HMDB01257
type: Species
has only substance units: false
is: CHEBI:57834
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR MM8Cg
reversible: false
modifier: MODEL1310110010#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
type: Reaction
is: SBO:0000176
reactant: MODEL1310110010#

metaM malttr e
is: C01835
boundary condition: false
is: SBO:0000247
is: HMDB01262
is: CHEBI:27931
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
constant: false
name: maltotriose

http://identifiers.org/biomodels.db/MODEL1310110010#_324481ea_9910_4e89_bb86_7c05ac1b108e
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:4720
initial concentration: NaN
is: B7Z792
name: NDUFS2
has only substance units: false
type: Species

metaR G14Tg
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
type: Reaction
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM prostgh2 c
is: CHEBI:57405
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01381
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
name: prostaglandin H2(1-)
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_3ff6cf31_3e8c_40b6_ae95_4f0d77428921
has only substance units: false
name: DGKB
is encoded by: hsa:1607
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM 44mzym r
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:18364
type: Species
initial concentration: 1.0
is: HMDB01286
boundary condition: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
name: 14-demethyllanosterol

metaR ACACT1rm
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110010#

metaR EX fucacgalfucgalacglcgalgluside hs LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1 exchange
type: Reaction

metaR UGLT
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.12
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
product: MODEL1310110010#
type: Reaction
reversible: true

metaR DHPM1
modifier: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.2.2
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
name: dihydropyrimidinase (5,6-dihydrouracil)

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaR r1512
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Utilized transport
product: MODEL1310110010#
is: SBO:0000185
reversible: false
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
type: Reaction

metaM 7dhchsterol r
boundary condition: false
name: cholesta-5,7-dien-3beta-ol
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:17759
has only substance units: false
is: HMDB00032
is: SBO:0000247
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164

http://identifiers.org/biomodels.db/MODEL1310110010#_dbe29434_896b_473b_b31b_d90f69142871
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:286297
name: _286297_1_c

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_e05fe3cd_056e_422e_98f5_ce1bdd236060
is: SBO:0000252
boundary condition: true
constant: false
is: P54687
name: BCAT1
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:586
initial concentration: NaN

metaR RE3347C
fast: false
name: RE3347
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
product: MODEL1310110010#

metaM glyc e
initial amount: NaN
is: HMDB00131
is: CHEBI:17754
boundary condition: false
name: Glycerol
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
initial concentration: 1.0
type: Species

metaM co2 r
is: C00011
constant: false
name: CO2
initial concentration: 1.0
is: CHEBI:16526
has only substance units: false
boundary condition: false
type: Species
is: HMDB01967
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_45cb911b_36cd_4d4e_bf9a_feb30b39af8f
name: UPP1
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:7378
has only substance units: false
boundary condition: true
is: Q16831

http://identifiers.org/biomodels.db/MODEL1310110010#_5b634f7b_196b_4c3d_91b9_20e233231062
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:374907
name: B3GNT8
boundary condition: true
initial amount: NaN
is: Q7Z7M8

http://identifiers.org/biomodels.db/MODEL1310110010#_240dc373_5f46_4e5e_b19a_a0204e9485cb
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: _AI935189_1_m
has only substance units: false
is encoded by: hsa:AI935189

http://identifiers.org/biomodels.db/MODEL1310110010#_a3b93334_246f_49bf_8598_bd55cc835b60
is: SBO:0000252
is encoded by: hsa:AA614647
name: _AA614647_1_c
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR GGH 7DHFe
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110010#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (7DHF), extracellular
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110010#
modifier: MODEL1310110010#

metaM sphmyln hs c
is: SBO:0000247
is: HMDB00156
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: sphmyln_hs[c]
notes: FORMULA: CHARGE: 0
constant: false
type: Species
is: CHEBI:15589

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM ksi pre18 g
is: SBO:0000247
is: CHEBI:58053
is: C00130
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 18
constant: false
boundary condition: false
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
is: HMDB00175

metaR S23T3g
modifier: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.99.6
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
reversible: false
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
fast: false
product: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
type: Reaction

metaR PPItx
type: Reaction
is: SBO:0000185
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
reactant: MODEL1310110010#
name: Diphosphate transporter, peroxisome

metaM nadp r
is: C00006
has only substance units: false
constant: false
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:58349

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaM prostge2 c
is: HMDB01220
constant: false
initial concentration: 1.0
is: CHEBI:606564
boundary condition: false
name: prostaglandin E2(1-)
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584

metaR r1799
fast: false
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_43424598_b35e_4a53_9f9a_a78464dccf66
is encoded by: hsa:54511
name: HMGCLL1
is: SBO:0000252
boundary condition: true
type: Species
constant: false
has only substance units: false
is: Q9NT06
initial concentration: NaN
initial amount: NaN

metaM ksi deg15 l
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 15
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
has only substance units: false
is: HMDB00143

metaM ksi deg33 l
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
has only substance units: false
is: CHEBI:12936
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 33
type: Species
boundary condition: false

metaR r1088
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Active transport
is described by: ECO:0000000
fast: false

metaM 3mob e
constant: false
is: CHEBI:11851
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00019
name: 3-methyl-2-oxobutanoate
type: Species

metaR r0083
fast: false
is: SBO:0000176
product: MODEL1310110010#
type: Reaction
reversible: true
reactant: MODEL1310110010#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110010#
is described by: ECO:0000000

metaR OCCOAtx
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
is: SBO:0000185
name: fatty acid intracellular transport
fast: false

metaR SGALSIDEtg
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
name: sgalside hs intracellular transport
type: Reaction
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#

metaM tststerone r
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: testosterone
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: CHEBI:17347
is: HMDB00234
boundary condition: false

metaR r0196
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
type: Reaction
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
product: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_5d939b82_36e9_45f6_85ca_3e9e95718c3f
constant: false
is encoded by: hsa:3030
is: E9KL44
type: Species
name: HADHA
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_861d3ff4_1b61_480a_9a23_a9a1c234d962
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:5161
is: P29803
boundary condition: true
name: PDHA2
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_1a3050f2_6f2d_409b_88d1_f9cd7e772829
is encoded by: hsa:1349
has part: Q7Z4L0
is encoded by: hsa:1329
has part: P20674
has part: Q7GXY8
has part: P00414
is encoded by: hsa:1351
type: Species
has part: Q96KJ9
is encoded by: hsa:1337
is encoded by: hsa:9377
is encoded by: hsa:1345
constant: false
is encoded by: hsa:9167
is encoded by: hsa:4512
initial amount: NaN
is encoded by: hsa:4513
is encoded by: hsa:1347
has part: Q6YFQ2
is encoded by: hsa:84701
has part: Q6FGA0
is encoded by: hsa:1350
is encoded by: hsa:1340
has part: Q02221
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:170712
is: SBO:0000297
is encoded by: hsa:341947
is encoded by: hsa:1327
is encoded by: hsa:125965
has part: P24310
has part: P24311
has part: Q8TF08
has part: P15954
has part: Q53YB7
boundary condition: true
has part: P12074
initial concentration: NaN
is encoded by: hsa:1339
is encoded by: hsa:1346
has part: P13073
has only substance units: false
has part: P14854
has part: Q53XN1
has part: Q7GXZ8
is encoded by: hsa:4514
has part: P09669
has part: H0UI06

metaM gtp m
name: GTP
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: C00044
boundary condition: false
has only substance units: false
is: HMDB01273
is: CHEBI:37565

metaR r1685
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#

metaR PROSTGF2t
kinetic law: MODEL1310110010#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
type: Reaction
name: prostaglandin uniport

metaM co2 m
initial amount: NaN
is: CHEBI:16526
is: C00011
name: CO2
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_8b17f409_2bcc_40de_a75a_56768bb41d14
initial amount: NaN
is: Q9H3H5
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1798
is: SBO:0000252
constant: false
type: Species
name: DPAGT1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_5a879766_9b7a_457a_b9aa_4bcaedecb8c8
type: Species
is encoded by: hsa:83549
initial concentration: NaN
initial amount: NaN
is: Q5JT09
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: UCK1

metaM q10h2 m
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: HMDB13111
is: SBO:0000247
name: Ubiquinol-10
boundary condition: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/6504740

metaR ACOAD1fm
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is described by: ECO:0000269
reactant: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is: SBO:0000176
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)

http://identifiers.org/biomodels.db/MODEL1310110010#_5b4d210a_d5fc_4d29_a766_2f7cb7127c64
is encoded by: hsa:7357
is: SBO:0000252
name: UGCG
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q16739
type: Species
initial amount: NaN

metaR RE2541E
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
name: RE2541
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
type: Reaction
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_db1a8567_a9fb_4e33_b882_5cfdce10fbf4
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: SLC16A7
is: Q8NEM3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9194
constant: false

metaM prostgh2 e
type: Species
is: HMDB01381
has only substance units: false
boundary condition: false
is: CHEBI:57405
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
name: prostaglandin H2(1-)

http://identifiers.org/biomodels.db/MODEL1310110010#_ff8ff044_98a0_40d8_8716_09144d016177
initial concentration: NaN
is: Q96KH8
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6530
name: SLC6A2
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_7aa3f464_f0e1_4b70_b993_ee520e673cd1
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI640625
initial amount: NaN
name: _AI640625_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_595461dd_ab4b_4909_b4cc_3d094136893b
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: HMGCR
type: Species
is: P04035
is encoded by: hsa:3156

metaR DESAT22 1p
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_1474d713_14a7_4cdf_b661_7414fd1c41a4
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:8703
boundary condition: true
name: B4GALT3
has only substance units: false
initial concentration: NaN
constant: false
is: A8K5Z0

metaR PPItr
product: MODEL1310110010#
reactant: MODEL1310110010#
name: Diphosphate transporter, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR CLPNDCOAtx
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: fatty acid intracellular transport
reactant: MODEL1310110010#
product: MODEL1310110010#
reversible: true

metaR 2MCITt
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
kinetic law: MODEL1310110010#
is: SBO:0000185
name: 2-methylcitrate transport via diffusion
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_c60357ef_c11c_458c_874e_7b1b21514d65
constant: false
name: BTD
initial concentration: NaN
initial amount: NaN
is: P43251
is encoded by: hsa:686
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_df91921d_b495_49ba_8d53_ff8d0666a5ad
initial concentration: NaN
is encoded by: hsa:4830
name: NME1:NME2
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000297
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ae8b9584_ef1b_4b45_9386_8a807ebb83cb
type: Species
is: Q9BV10
name: ALG12
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:79087
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r1797
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#

metaM nadp x
is: CHEBI:58349
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
is: HMDB00217
boundary condition: false
is: C00006
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

metaM HC01401 m
boundary condition: false
is: CHEBI:27668
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial amount: NaN
type: Species

metaM HC01459 x
is: CHEBI:27458
initial amount: NaN
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110010#_f10bb121_5225_4dd0_9489_aaf827a27109
is: SBO:0000252
type: Species
is: P21953
name: BCKDHB
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:594
initial concentration: NaN
has only substance units: false

metaM ahcys c
is: C00021
initial amount: NaN
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
constant: false
is: CHEBI:16680
has only substance units: false
boundary condition: false
is: HMDB00939
initial concentration: 1.0
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021

metaM ksii core2 pre8 g
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C00130
type: Species
is: SBO:0000247
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial amount: NaN
is: HMDB00175
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 8

http://identifiers.org/biomodels.db/MODEL1310110010#_ab5f25be_0b2f_45c6_bf5a_91b87549c0c6
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:126
has only substance units: false
initial concentration: NaN
name: ADH1A:ADH1C
has part: P00326
boundary condition: true
type: Species
constant: false

metaR GLNtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
name: L-glutamine transport via electroneutral transporter
kinetic law: MODEL1310110010#
is: SBO:0000185
reversible: false
product: MODEL1310110010#

metaM 3mob c
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
initial concentration: 1.0
is: CHEBI:11851
constant: false
boundary condition: false
initial amount: NaN
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
type: Species

metaM fad x
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_07dd014d_0b5e_4f09_a63f_8369994bdfe9
initial amount: NaN
is encoded by: hsa:AI222095
boundary condition: true
constant: false
has only substance units: false
name: _AI222095_1_m
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r0081
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: true
reactant: MODEL1310110010#
is described by: ECO:0000000
modifier: MODEL1310110010#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
product: MODEL1310110010#

metaR MTHFCm
reversible: true
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.3.4.3
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
reactant: MODEL1310110010#
is described by: ECO:0000269
kinetic law: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is: SBO:0000176
modifier: MODEL1310110010#

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR r1008
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction
name: Facilitated diffusion
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_6229b805_4c2e_4262_98fa_3e6b7c423fc0
name: BPNT1
boundary condition: true
is: O95861
initial concentration: NaN
type: Species
is encoded by: hsa:10380
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM uacgam c
type: Species
is: HMDB00290
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false
has only substance units: false
initial amount: NaN

metaR r1796
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_0fc0df87_2843_436d_ae6d_78acf95b6252
is: SBO:0000252
is: Q9Y217
type: Species
name: MTMR6
is encoded by: hsa:9107
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_1569bf9b_4bbf_4698_888b_f622c0b438f0
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:6561
name: SLC13A1
constant: false
boundary condition: true
is: Q9BZW2

http://identifiers.org/biomodels.db/MODEL1310110010#_eb39507c_2aca_4ff9_ad88_6dc873be2305
initial concentration: NaN
initial amount: NaN
name: FUT8
is: Q9BYC5
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2530
constant: false

metaR r2030
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110010#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_0ed72a31_7a13_4310_b49b_40e54beb842b
has only substance units: false
name: SLC35A2
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:7355
is: P78381
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR GALASE8ly
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110010#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
fast: false

metaR DOLGLCP Uter
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110010#
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
product: MODEL1310110010#

metaM gua e
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:16235
is: SBO:0000247
initial amount: NaN
name: guanine
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_8eaa572e_83f6_4a67_bbfa_92022dce1e24
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:6901
type: Species
constant: false
initial concentration: NaN
name: TAZ
is: Q16635

http://identifiers.org/biomodels.db/MODEL1310110010#_0a3cd15b_2bb4_4b86_bb03_412c4e0ab5bc
type: Species
name: AOC3
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q16853
is encoded by: hsa:8639
has only substance units: false
is: SBO:0000252
constant: false

metaR r0193
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
reversible: true
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
kinetic law: MODEL1310110010#
is described by: ECO:0000000
fast: false

metaR r1682
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
reversible: false
reactant: MODEL1310110010#
name: Y+LAT2 Utilized transport
fast: false
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM sph1p e
initial amount: NaN
has only substance units: false
is: CHEBI:57939
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: HMDB01383
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM hgentis c
name: homogentisate
boundary condition: false
has only substance units: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
is: CHEBI:16169
initial amount: NaN
type: Species
constant: false
is: HMDB00130
is: SBO:0000247
initial concentration: 1.0

metaR r0339
reversible: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
modifier: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.22
product: MODEL1310110010#

metaM pchol hs r
is: CHEBI:16110
boundary condition: false
initial concentration: 1.0
name: Phosphatidylcholine
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
has only substance units: false
is: SBO:0000247
type: Species
constant: false

metaM gtp n
is: CHEBI:37565
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
has only substance units: false
is: HMDB01273
boundary condition: false
name: GTP(4-)
initial amount: NaN
constant: false

metaM cmp n
initial amount: NaN
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
is: SBO:0000247
is: CHEBI:60377
type: Species
initial concentration: 1.0
is: HMDB00095
has only substance units: false
boundary condition: false

metaR TRPt
modifier: MODEL1310110010#
is described by: ECO:0000269
name: L-tryptophan transport
kinetic law: MODEL1310110010#
reversible: true
fast: false
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:

metaM ahcys e
is: SBO:0000247
constant: false
is: CHEBI:16680
name: S-Adenosyl-L-homocysteine
is: HMDB00939
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0
initial amount: NaN
is: C00021

metaR DOLDPP Uer
is described by: ECO:0000000
reactant: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.6.1.43
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_975ab858_1bed_4533_b286_3f2ea7ba31b8
type: Species
name: GMPPB
is: Q9Y5P6
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:29925

metaR HIStN1
reversible: true
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
modifier: MODEL1310110010#
name: Histidine transport (Na, H coupled)
product: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR S6TASE22ly
product: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
kinetic law: MODEL1310110010#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
name: galactose-6-sulfate sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110010#_390f3580_2dbd_4cd4_824d_122d040fba07
name: IDH1
constant: false
is encoded by: hsa:3417
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: O75874
is: SBO:0000252
has only substance units: false
type: Species

metaR DTMPKm
type: Reaction
reversible: true
is: SBO:0000176
name: dTMP kinase in mitochondria
kinetic law: MODEL1310110010#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: Confidence Level: 4 AUTHORS: PMID: 17403938 NOTES:
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#

metaR NACHEXA22ly
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110010#

metaM nm4masn g
initial amount: NaN
type: Species
is: C05882
notes: FORMULA: C54H90N3O40X CHARGE: 0
is: SBO:0000247
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false

metaR FAOXC16080m
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_2d108a0b_c6c8_4003_ab62_869d415cf877
name: QPRT
boundary condition: true
constant: false
type: Species
is: Q15274
is encoded by: hsa:23475
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_b536cf7b_184a_4287_a314_275cadb32965
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: P49327
type: Species
name: FASN
is encoded by: hsa:2194
constant: false
initial concentration: NaN

metaR DM core7 g
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM core7(g)
type: Reaction

metaM HC02216 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: prostaglandin-f2beta
is: CHEBI:28922
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR FTHFL
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110010#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.5.1.5
name: Formate-tetrahydrofolate ligase
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR EX pectintchol LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-taurocholic acid complex
type: Reaction

metaM doldp U r
constant: false
boundary condition: false
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
is: SBO:0000247
has only substance units: false
name: Dolichol diphosphate, human uterine homolog
is: CHEBI:15750
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_b6403314_ed30_4ac7_aa46_c9cea92f6eca
has part: Q86TM7
has part: O60762
is: SBO:0000297
initial amount: NaN
type: Species
is encoded by: hsa:8813
has only substance units: false
boundary condition: true
has part: O94777
is encoded by: hsa:8818
initial concentration: NaN
name: DPM3:DPM1:DPM2
constant: false
is encoded by: hsa:54344

metaR L LACDcm
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
is: SBO:0000185
modifier: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
reversible: false
type: Reaction

metaR FUMtm
kinetic law: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
reactant: MODEL1310110010#
is described by: ECO:0000269
name: fumarate transport, mitochondrial
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110010#
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_a36d0e35_d0d4_4ad2_9450_73b45da6f8bc
is: Q16720
initial concentration: NaN
is encoded by: hsa:492
has only substance units: false
constant: false
boundary condition: true
name: ATP2B3
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_006696ae_cffa_4815_93e3_9745580ef432
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:3295
is: E9PB82
type: Species
name: HSD17B4

metaM retinal cis 13 c
has only substance units: false
name: 13-cis-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB06220
initial amount: NaN
is: CHEBI:45487

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaM tethex3 e
is: HMDB02007
type: Species
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
name: tetracosahexaenoic acid, n-3
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaM andrstrn r
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:16032
initial amount: NaN
initial concentration: 1.0
name: androsterone
is: HMDB00031
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523

metaR NMNATr
reversible: true
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.7.1
is: SBO:0000176
name: nicotinamide-nucleotide adenylyltransferase

http://identifiers.org/biomodels.db/MODEL1310110010#_5cfeaf32_0930_4859_bab4_0fd894114682
is encoded by: hsa:6576
type: Species
name: SLC25A1
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: D9HTE9
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_24cab8fc_168b_4320_8019_dea92703514e
name: TMEM91
is: C9JZ62
type: Species
is: SBO:0000252
is encoded by: hsa:641649
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaR RE3565C
product: MODEL1310110010#
is described by: ECO:0000000
name: RE3565
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
reversible: true
fast: false

metaM 2oxoadp m
name: 2-oxoadipate(2-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:57499
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00225
has only substance units: false
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322

metaM co2 x
is: HMDB01967
is: CHEBI:16526
boundary condition: false
constant: false
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: carbon dioxide
type: Species
initial amount: NaN

metaM HC02207 e
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: prostaglandin-c2
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: CHEBI:27555

http://identifiers.org/biomodels.db/MODEL1310110010#_8b64db24_d01d_4055_a891_c2e71bf6c229
has only substance units: false
is: Q10469
name: MGAT2
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4247
constant: false
is: SBO:0000252

metaR LEUKTRF4t
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110010#
name: leukotriene F4 transport
is described by: ECO:0000000
reactant: MODEL1310110010#
reversible: true
type: Reaction
is: SBO:0000185

metaR TYRCBOX
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000134
name: L-Tyrosine carboxy-lyase
product: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.28

metaR UDPGLCter
product: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
kinetic law: MODEL1310110010#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_9a3815ff_01d2_40bc_89bd_9a38f6191528
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: B3GNT2
is: SBO:0000252
is encoded by: hsa:10678
constant: false
initial amount: NaN

metaM hista e
constant: false
initial amount: NaN
type: Species
name: histamium
is: HMDB00870
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432

http://identifiers.org/biomodels.db/MODEL1310110010#_4e7c619e_8f81_452f_911f_95929107e2f2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI620219
has only substance units: false
boundary condition: true
constant: false
type: Species
name: _AI620219_1_m

metaR FE2t
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
reactant: MODEL1310110010#
name: iron (II) transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: false
is described by: ECO:0000000

metaR CHOLK
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
type: Reaction
name: Choline kinase
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000269
modifier: MODEL1310110010#
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_bfa817ca_5b9d_4a86_87a9_4836f81f8fc5
is encoded by: hsa:AI373818
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: _AI373818_1_m
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r0086
reversible: false
modifier: MODEL1310110010#
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.5.1.3
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
kinetic law: MODEL1310110010#

metaR UROLACer
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
is: SBO:0000176
name: uronolactonase, endoplasmic reticulum
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_a20b215b_e7b7_4321_9e1f_1f62d48bb371
is encoded by: hsa:79053
boundary condition: true
constant: false
name: ALG8
is: SBO:0000252
has only substance units: false
type: Species
is: Q9BVK2
initial concentration: NaN
initial amount: NaN

metaR UGCG
modifier: MODEL1310110010#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
kinetic law: MODEL1310110010#
name: Ceramide glucosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.80

http://identifiers.org/biomodels.db/MODEL1310110010#_15e1ee7f_4388_4d39_83e0_0b3f36d9cec3
name: LHPP
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:64077
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9H008

http://identifiers.org/biomodels.db/MODEL1310110010#_5a39164c_71a1_42ee_a249_410438d2a8aa
is: Q6IA69
constant: false
is: SBO:0000252
is encoded by: hsa:55191
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: NADSYN1
type: Species

metaM uacgam g
is: HMDB00290
is: CHEBI:57705
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0

metaM fuc1p L c
is: CHEBI:28319
initial concentration: 1.0
constant: false
is: SBO:0000247
name: L-Fucose 1-phosphate
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: HMDB01265
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_39790fc4_1d10_4319_b7dc_97098f3a300f
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:8898
type: Species
is: SBO:0000252
name: MTMR2
is: A6NN98
boundary condition: true
initial concentration: NaN

metaM pmtcoa x
is: HMDB01338
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial amount: NaN
is: CHEBI:57379
is: C00154
constant: false
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ab17c6c5_009d_4b29_a8ff_bf7d2da533d6
has only substance units: false
initial amount: NaN
is encoded by: hsa:23057
boundary condition: true
is: Q9BZQ4
initial concentration: NaN
name: NMNAT2
is: SBO:0000252
type: Species
constant: false

metaM orn m
is: CHEBI:46912
type: Species
constant: false
is: C01602
boundary condition: false
has only substance units: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: HMDB00214
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Ornithine

metaM HC02205 c
constant: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
boundary condition: false
is: CHEBI:28099
name: prostaglandin-b2
has only substance units: false
type: Species
initial amount: NaN

metaR DIGALSGALSIDEtg
name: digalsgalside hs intracellular transport
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
type: Reaction
reactant: MODEL1310110010#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110010#

metaM mescon m
is: HMDB00749
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:36986
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
name: Mesaconate
has only substance units: false

metaR ORNt3m
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
reversible: true
kinetic law: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
name: ornithine mitochondrial transport via proton antiport
is described by: ECO:0000269

metaR r0085
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is: SBO:0000176
product: MODEL1310110010#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110010#

metaM 3otdcoa m
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 3-Oxotetradecanoyl-CoA
is: SBO:0000247
type: Species
is: HMDB03935
initial amount: NaN
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
is: CHEBI:28726

http://identifiers.org/biomodels.db/MODEL1310110010#_a33fe9bf_e286_4fc1_be18_38b1a0448e95
is encoded by: hsa:276
has only substance units: false
constant: false
name: AMY1A
boundary condition: true
is: Q6NSB3
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaM oxa c
constant: false
is: HMDB02329
type: Species
boundary condition: false
is: CHEBI:30623
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_10c0de6f_6ed0_4e46_9c65_b5ce2b718ea7
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O95045
initial amount: NaN
type: Species
name: UPP2
is encoded by: hsa:151531
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_19f994ac_6119_403f_91c4_d941efd1e239
name: MTHFD1
boundary condition: true
type: Species
is encoded by: hsa:4522
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P11586

metaM tethex3 c
boundary condition: false
initial amount: NaN
has only substance units: false
name: tetracosahexaenoic acid, n-3
is: SBO:0000247
constant: false
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
initial concentration: 1.0
is: HMDB02007
type: Species

metaR r1943
kinetic law: MODEL1310110010#
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
is described by: ECO:0000000

metaR r0679
modifier: MODEL1310110010#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR r1791
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110010#
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110010#
reversible: false
is described by: ECO:0000000

metaM tym c
name: tyraminium
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
is: CHEBI:327995
initial concentration: 1.0
is: HMDB00306
is: SBO:0000247
has only substance units: false

metaR DNDPt26m
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110010#
name: dCDP transport via dUDP antiport
product: MODEL1310110010#
is described by: ECO:0000269
kinetic law: MODEL1310110010#
is: SBO:0000185
modifier: MODEL1310110010#

metaM tststerone e
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: testosterone
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: CHEBI:17347
is: HMDB00234
type: Species
is: SBO:0000247
has only substance units: false

metaR DOLMANP Uter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol-phosphate mannose flippase (uterus)
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: false
type: Reaction
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_1eb300e7_0162_4f0d_8752_2c8271feb232
is: SBO:0000252
has only substance units: false
constant: false
name: ABCB4
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:5244
is: A4D1D5
boundary condition: true

metaM HC02207 c
is: CHEBI:27555
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: false
name: prostaglandin-c2

metaM cala c
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: HMDB00026
initial amount: NaN
constant: false
is: CHEBI:11892
name: N-carbamoyl-beta-alaninate
is: SBO:0000247
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642

metaR VITD3Hm
fast: false
product: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110010#
name: Vitamin D-25-hydroxylase (D3)
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:7690968 NOTES:based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.196 IT; RE1303M
type: Reaction
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110010#

metaR r0084
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
reversible: true

metaM hista c
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: HMDB00870
initial amount: NaN
is: SBO:0000247
name: histamium
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58432
type: Species

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM q10h2 e
constant: false
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247
name: Ubiquinol-10
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB13111
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

metaR ATPtx
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110010#
fast: false
name: ATP transporter, peroxisomal
reactant: MODEL1310110010#

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR r0954
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
kinetic law: MODEL1310110010#
name: MCT 1 Transport reaction
product: MODEL1310110010#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR RE2649C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
modifier: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110010#
name: RE2649
kinetic law: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_ef9b4784_f018_4e55_bed8_d98d9a8e96c3
initial concentration: NaN
is: SBO:0000252
is: G3XAJ0
name: ACAD10
initial amount: NaN
constant: false
is encoded by: hsa:80724
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_95e30de4_8afb_4b57_beac_bee82d742168
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:9377
constant: false
name: COX5A
initial amount: NaN
is: P20674

http://identifiers.org/biomodels.db/MODEL1310110010#_ad4de6c1_e4f0_4af6_b7e0_400e68db332b
name: NDUFV1
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4723
is: E5KNH5

metaR HAS2
is described by: ECO:0000269
kinetic law: MODEL1310110010#
name: hyaluronan synthase
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.212
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
type: Reaction
reversible: false
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_31e0261a_c1d1_4668_b6da_5533c8830c4e
constant: false
is encoded by: hsa:18
name: ABAT
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_36091ea8_1598_445a_975c_e035bf7dc10b
initial amount: NaN
is: Q9NY65
name: EHHADH
constant: false
is encoded by: hsa:1962
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_df6537d1_7ebd_4bfb_a91e_6152bdd6f652
type: Species
is encoded by: hsa:2650
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: GCNT1
constant: false
has only substance units: false
is: Q02742
initial concentration: NaN

metaM phaccoa c
is: HMDB06503
initial concentration: 1.0
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: phenylacetyl-CoA(4-)
is: CHEBI:57390

metaR LPS3e
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.3
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reversible: false
name: lipase, extracellular
fast: false
reactant: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#

metaR FADtx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
fast: false
name: FAD transporter, peroxisomal
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_da674069_1b61_47ce_a384_2a533bc511d9
constant: false
type: Species
is: Q9BZ23
initial amount: NaN
boundary condition: true
is encoded by: hsa:80025
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PANK2

metaM cholate c
is: HMDB00619
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: Cholate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
is: CHEBI:29747

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_e93d0f4c_71eb_4048_a7a9_00776a12ccb4
name: ALDH2
is encoded by: hsa:217
is: P05091
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaM crn x
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
has only substance units: false
is: CHEBI:16347
name: L-Carnitine
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_95233d62_66e7_44c4_8b66_d7bbe79d7e80
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2348
type: Species
is: SBO:0000252
initial amount: NaN
name: FOLR1

metaR r0881
reactant: MODEL1310110010#
fast: false
type: Reaction
product: MODEL1310110010#
reversible: false
kinetic law: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
name: Active transport
is described by: ECO:0000000

metaR DIGALSGALSIDEte
product: MODEL1310110010#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
name: digalsgalside hs transport

metaM ksii core2 deg3 l
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
is: SBO:0000247
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 3
is: CHEBI:12936
constant: false
type: Species

metaR TCYNTtm
fast: false
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
name: Thiocyanate transport via diffusion (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
kinetic law: MODEL1310110010#
reversible: false

metaR RE1526M
name: RE1526
modifier: MODEL1310110010#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#
product: MODEL1310110010#

metaM HC02205 e
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
type: Species
is: CHEBI:28099
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: prostaglandin-b2
constant: false
has only substance units: false

metaR AG13T11g
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
reversible: false
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR G6PDH2rer
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
fast: false
modifier: MODEL1310110010#
is described by: ECO:0000269
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM oxa e
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
is: HMDB02329
name: oxalate(2-)
is: CHEBI:30623
constant: false
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN

metaM ksii core4 e
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00211
is: CHEBI:17268
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_260cd12a_93e3_4487_b55f_61590990dd1a
is encoded by: hsa:AI348006
boundary condition: true
name: _AI348006_1_c
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaR RE3624M
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE3624
is: SBO:0000176
reversible: false
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#

metaR O2tm
type: Reaction
name: O2 transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
reversible: true
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
is described by: ECO:0000000

metaR 5MTHFt2le
reversible: true
is described by: ECO:0000134
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
name: 5-methyltetrahydrofolate transport via anion exchange
type: Reaction

metaM btcoa m
is: C00136
initial concentration: 1.0
has only substance units: false
name: Butanoyl-CoA
type: Species
is: CHEBI:57371
boundary condition: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01088

http://identifiers.org/biomodels.db/MODEL1310110010#_2843df4d_10ac_46c4_a68f_99872a2cd5fb
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P56181
has only substance units: false
initial amount: NaN
is encoded by: hsa:4731
constant: false
name: NDUFV3

metaM pail hs n
constant: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:57880
type: Species
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false
initial amount: NaN

metaM gtp c
is: CHEBI:37565
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00044
boundary condition: false
name: GTP
constant: false
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_df0a5163_ab31_46cf_b866_a88a71f6c27d
name: PKM2
has only substance units: false
initial amount: NaN
is: P14618
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:5315

http://identifiers.org/biomodels.db/MODEL1310110010#_abeaa17f_00e0_4c78_8d87_090decf5ef54
type: Species
is encoded by: hsa:6526
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
name: SLC5A3
initial amount: NaN
initial concentration: NaN
is: P53794

metaM gal c
is: HMDB00143
is: SBO:0000247
constant: false
is: C00124
is: CHEBI:0
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0
type: Species
has only substance units: false
name: D-Galactose

http://identifiers.org/biomodels.db/MODEL1310110010#_5eed4216_071a_4cc6_b4bf_f8970b8be48e
initial amount: NaN
is encoded by: hsa:54344
constant: false
type: Species
is: Q86TM7
name: DPM3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR CHOLt4
reactant: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
type: Reaction
fast: false
name: choline, sodium cotransport
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110010#
reversible: true

metaM apoC m
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
type: Species
is: CHEBI:32551
boundary condition: false
name: Apocarboxlase (no lys residue)
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00182
is: SBO:0000247

metaR B3GNT51g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
fast: false
is described by: ECO:0000304
reactant: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_bcd8228d_5750_48d4_ba63_078b13f5cb22
is: Q15125
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: EBP
is encoded by: hsa:10682
is: SBO:0000252

metaR FACOAL80i
type: Reaction
name: fatty-acid--CoA ligase (octanoate)
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000269
modifier: MODEL1310110010#
reversible: false
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_0bff6f7d_15b5_4dee_861c_ee3eafd2b05d
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AL048840
initial concentration: NaN
name: _AL048840_1_c
initial amount: NaN

metaM q10h2 c
name: Ubiquinol-10
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB13111

http://identifiers.org/biomodels.db/MODEL1310110010#_e4a9cd4f_c191_4403_a74a_a2ad190a293f
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:55293
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q8IX04
name: UEVLD
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_fb48d90c_c1ab_4e10_b86b_19c5fa43977f
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: COL4A3BP
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10087
has only substance units: false
is: Q9Y5P4

metaM thbpt4acam c
initial concentration: 1.0
is: CHEBI:15374
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
is: HMDB02281
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_6d2564dc_af1b_4d13_a58d_1b0aceb73f16
name: _AI694761_1_c
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI694761
initial concentration: NaN

metaR BDHm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
modifier: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.30
fast: false
type: Reaction
reversible: true
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
reactant: MODEL1310110010#
product: MODEL1310110010#

metaR r1621
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_808aa02a_1378_4941_b09c_c064c68ae1ff
is encoded by: hsa:AA526438
name: _AA526438_1_m
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_d9c04c53_badc_464c_9a09_b5a5467d5c5a
initial amount: NaN
name: MPST
is: P25325
type: Species
is encoded by: hsa:4357
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true

metaM cholate e
has only substance units: false
type: Species
is: CHEBI:29747
name: Cholate
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
boundary condition: false
is: HMDB00619

metaM HC02216 c
has only substance units: false
name: prostaglandin-f2beta
constant: false
is: CHEBI:28922
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110010#_02f5fdfe_1550_406b_8a91_f40d2bcb0558
is: SBO:0000252
is encoded by: hsa:23305
name: ACSL6
boundary condition: true
is: B2RB13
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaM ksii core4 g
is: SBO:0000247
is: HMDB01014
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: CHEBI:57255
initial concentration: 1.0
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_7e60979e_847c_4369_90e2_0a1ff50cb4fe
is: B4DK61
constant: false
name: ACOX1
is encoded by: hsa:51
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR FACOAL180i
modifier: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110010#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
name: C180 fatty acid activation

http://identifiers.org/biomodels.db/MODEL1310110010#_dae52dbf_41bf_4052_ab0b_890d18c086e6
initial concentration: NaN
type: Species
constant: false
is: Q96CD2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:60490
has only substance units: false
name: PPCDC
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_3c76ec53_7ba8_4dca_9746_553c8b492fd4
boundary condition: true
is encoded by: hsa:6487
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: ST3GAL3
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_dd227bc3_615a_4be4_9520_7991c3d80dda
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:763
is: P35218
type: Species
name: CA5A
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

metaR GALASE14ly
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000176
name: beta-galactosidase, lysosomal
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
modifier: MODEL1310110010#
is described by: ECO:0000000

metaR SGALSIDEtl
kinetic law: MODEL1310110010#
name: sgalside hs intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
fast: false
is described by: ECO:0000000

metaR EBP1r
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/5.3.3.5
type: Reaction
fast: false
product: MODEL1310110010#
is: SBO:0000176
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase

metaR r1728
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110010#
product: MODEL1310110010#

metaR r1620
product: MODEL1310110010#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000

metaM arachcrn m
initial amount: NaN
name: arachidyl carnitine
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: HMDB06460
has only substance units: false

metaM amet c
name: S-Adenosyl-L-methionine
boundary condition: false
is: CHEBI:15414
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: C00019
initial concentration: 1.0
is: SBO:0000247
is: HMDB01185
constant: false
has only substance units: false
initial amount: NaN

metaR DOPAtu
is described by: ECO:0000269
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
name: Dopamine uniport
type: Reaction

metaM msa m
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB11111
name: 3-oxopropanoate
constant: false
is: CHEBI:33190
is: SBO:0000247

metaM lnlc r
is: CHEBI:30245
type: Species
name: linoleate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00673

metaM ksii core2 deg5 l
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C50H82N4O38SX CHARGE: -1
has only substance units: false
is: HMDB00143
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 5
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_26bd8fa1_581e_4b64_9897_9eb468dd147f
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6582
boundary condition: true
name: SLC22A2
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: O15244

metaR RE2651R
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
name: RE2651
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true

metaM tetpent6 c
initial amount: NaN
name: tetracosapentaenoic acid, n-6
is: HMDB06322
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_fab57db4_b8c3_4700_a24a_cbc6e3438616
name: ECH1
is: SBO:0000252
type: Species
is encoded by: hsa:1891
is: Q13011
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaM cholp c
is: CHEBI:295975
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: choline phosphate(1-)
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
has only substance units: false
is: SBO:0000247

metaM thr L c
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species
is: SBO:0000247
is: HMDB00167
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:16857
has only substance units: false
name: L-threonine
constant: false

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR r0560
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
reactant: MODEL1310110010#

metaR MACOXO
kinetic law: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#
reversible: false
is described by: ECO:0000269
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110010#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain

metaM 7dhchsterol c
constant: false
is: CHEBI:17759
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
boundary condition: false
initial concentration: 1.0
is: HMDB00032
is: SBO:0000247
has only substance units: false
type: Species
name: cholesta-5,7-dien-3beta-ol
initial amount: NaN

metaR BUTt2r
reversible: true
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
reactant: MODEL1310110010#
name: Butyrate transport via proton symport, reversible
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000185
fast: false

metaR r1562
is: SBO:0000185
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_b01e5330_f9e8_49f3_bbda_7492b75f3f12
has only substance units: false
is encoded by: hsa:N63787
boundary condition: true
name: _N63787_1_c
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM taur e
initial concentration: 1.0
boundary condition: false
is: CHEBI:3544
is: SBO:0000247
constant: false
name: Taurine
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
type: Species
has only substance units: false
is: C00245
initial amount: NaN

metaR r0739
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_29c5b571_e4b3_40ee_a6a3_868ac329b735
is: Q99714
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:3028
type: Species
initial amount: NaN
initial concentration: NaN
name: HSD17B10
has only substance units: false

metaR r1622
is: SBO:0000185
product: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000000

metaR NACHEXA9ly
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_5e6e192f_0943_4f1e_8cd8_83341ac879e4
has only substance units: false
name: GALNT10
type: Species
is encoded by: hsa:55568
constant: false
boundary condition: true
is: SBO:0000252
is: Q86SR1
initial concentration: NaN
initial amount: NaN

metaM 4ppcys m
type: Species
constant: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
boundary condition: false
has only substance units: false
is: CHEBI:59458

metaR r2310
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110010#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110010#

metaR ITCOAL1m
kinetic law: MODEL1310110010#
is described by: ECO:0000304
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
fast: false
product: MODEL1310110010#
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.4

metaR r0224
product: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
reversible: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_c17bac53_ef36_4aab_af7c_b55bab7358fe
name: ALDOC
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:230
initial concentration: NaN
is: P09972

metaR r0330
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
is: SBO:0000176
fast: false
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
type: Reaction
reversible: false

metaR r2534
is described by: ECO:0000000
product: MODEL1310110010#
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR NACHEXA11ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110010#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110010#
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110010#

metaR G14T4g
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110010#_e7afa029_b811_482c_b79d_cc7077e53151
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ATP2B4
constant: false
has only substance units: false
is encoded by: hsa:493
initial amount: NaN
is: P23634

metaR r0672
is: SBO:0000176
modifier: MODEL1310110010#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
reversible: true
reactant: MODEL1310110010#

metaM 5adtststerone e
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: SBO:0000247
is: CHEBI:16330
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR C226CRNt
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110010#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110010#
name: C226 transport into the mitochondria

metaR r1561
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: true
product: MODEL1310110010#

metaM ppi e
initial concentration: 1.0
has only substance units: false
is: HMDB00250
name: Diphosphate
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
constant: false
is: CHEBI:33019
type: Species
is: C00013
boundary condition: false

metaR SIAASE2ly
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110010#
type: Reaction

metaR r2028
product: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

metaR FAOXC204
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
reversible: false
type: Reaction
kinetic law: MODEL1310110010#
fast: false
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM nrpphrsf e
initial amount: NaN
constant: false
is: SBO:0000247
name: Sulfate derivative of norepinephrine
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/123747
initial concentration: 1.0
is: HMDB02062
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
has only substance units: false

metaR r1623
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_f392326d_dd0d_48ca_879e_3333400c02f6
type: Species
initial amount: NaN
name: NDUFA10
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4705
is: O95299
constant: false
initial concentration: NaN
has only substance units: false

metaM n2m2nmasn e
initial concentration: 1.0
boundary condition: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial amount: NaN
has only substance units: false
is: C04946

http://identifiers.org/biomodels.db/MODEL1310110010#_4f38b2c4_903f_47bb_969f_0c0030d62865
is: Q86VV3
initial concentration: NaN
constant: false
name: ENTPD1
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:953
has only substance units: false

metaR r0885
product: MODEL1310110010#
is: SBO:0000185
fast: false
modifier: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#

metaR r1010
type: Reaction
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reversible: true
name: Postulated transport reaction
is: SBO:0000185

metaR CYOOm3
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
fast: false
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
name: cytochrome c oxidase, mitochondrial Complex IV
is version of: http://identifiers.org/ec-code/1.9.3.1
type: Reaction
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_f15a6dda_df7d_4c9e_a613_79062676d456
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: DDC
is encoded by: hsa:1644
constant: false
initial concentration: NaN
is: Q53Y41
initial amount: NaN

metaR r2394
is: SBO:0000185
kinetic law: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110010#
is described by: ECO:0000000

metaM gal e
boundary condition: false
name: D-Galactose
is: HMDB00143
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:0
is: C00124

metaR FAOXC16080x
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110010#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000269
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110010#
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110010#

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR r2535
reversible: true
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_402f1923_9f3c_4c19_b2d1_b3208dc6b685
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:3033
name: HADH
initial concentration: NaN
constant: false
is: Q16836
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_c6ca3c53_cafe_48e5_adff_f74c2095f6fa
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: ACAD9
is: SBO:0000252
is: Q9H845
type: Species
is encoded by: hsa:28976
initial amount: NaN

metaR O2tp
fast: false
reversible: true
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000185
name: O2 transport, peroxisomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaR r1564
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1624
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110010#

metaM taur c
initial concentration: 1.0
is: C00245
initial amount: NaN
boundary condition: false
notes: FORMULA: C2H7NO3S CHARGE: 0
is: CHEBI:3544
name: Taurine
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00251
type: Species

metaR r1459
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Transport reaction
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
fast: false

metaR RE3006M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: RE3006
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM i e
initial concentration: 1.0
type: Species
constant: false
is: HMDB12238
is: SBO:0000247
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
name: iodide
has only substance units: false
is: CHEBI:16382
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_41e0abbe_f089_496e_8e77_647d3ca451f3
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:6532
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P31645
name: SLC6A4

metaR r0670
reversible: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110010#
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction

metaM HC00342 m
name: cis-aconitate(3-)
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:16383
initial concentration: 1.0
initial amount: NaN

metaM pe hs c
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16038
is: SBO:0000247
name: phosphatidylethanolamine

metaR FACOAL204
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
type: Reaction
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
product: MODEL1310110010#
is described by: ECO:0000269
fast: false

metaM crn r
is: HMDB00062
is: CHEBI:16347
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
name: (R)-carnitine
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_9cdb5162_b76f_45f0_8929_0609a5e8f5b7
is: SBO:0000252
constant: false
name: _H45672_1_m
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:H45672
type: Species

metaR r1563
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: true
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_69625210_cc3a_4873_8683_948a5b624296
type: Species
name: SLC25A20
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:788
is: O43772

metaM 5adtststerone c
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:16330
has only substance units: false
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
name: 17beta-hydroxy-5alpha-androstan-3-one
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_a0d2df18_da9e_42e0_8e93_03b7404497a2
type: Species
initial amount: NaN
is: P30084
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ECHS1
is encoded by: hsa:1892
is: SBO:0000252

metaR RE2659R
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110010#
name: RE2659

metaR GLCNACT U
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110010#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
is: SBO:0000176

metaR r1625
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
type: Reaction
is described by: ECO:0000000

metaM Lkynr c
is: HMDB00684
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
constant: false
name: L-kynurenine
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:16946

metaM bhb m
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
boundary condition: false
is: CHEBI:10983
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00011
initial concentration: 1.0
has only substance units: false

metaR r2392
reactant: MODEL1310110010#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110010#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_6fcf33b4_1675_4969_ab5b_646594a70b1f
initial amount: NaN
type: Species
name: CMPK1
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51727
initial concentration: NaN
is: B2R6S5

metaR GLRASE
reversible: true
reactant: MODEL1310110010#
name: glucuronolactone reductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110010#

metaR PROt2r
product: MODEL1310110010#
name: L-proline reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110010#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
fast: false

metaR NDP7g
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110010#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
modifier: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaM HC02187 c
type: Species
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: SBO:0000247
is: CHEBI:28774
name: reverse-triiodthyronine
initial concentration: 1.0
has only substance units: false

metaR TALA
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
fast: false
name: transaldolase
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.2
reactant: MODEL1310110010#
is described by: ECO:0000000
modifier: MODEL1310110010#

metaR r2537
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
type: Reaction
name: Utilized transport
reversible: true
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR RE2269E
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.21.39
reversible: true
product: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: RE2269
type: Reaction
kinetic law: MODEL1310110010#

metaR ACACT4p
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
product: MODEL1310110010#
fast: false
name: acetyl-CoA C-acetyltransferase (octanoyl-CoA), peroxisomal
reversible: false
type: Reaction
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#

metaR r2314
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110010#

metaR RNDR2
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: ribonucleoside-diphosphate reductase (GDP)
fast: false
reversible: false
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
modifier: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110010#_2bd7737d_3cc1_4da2_b7d2_5d3c1e1e437f
is: SBO:0000252
is encoded by: hsa:10568
constant: false
boundary condition: true
type: Species
is: O95436
has only substance units: false
initial concentration: NaN
name: SLC34A2
initial amount: NaN

metaM tststerone c
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:17347
initial concentration: 1.0
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
is: HMDB00234
name: testosterone
is: SBO:0000247

metaR CRNt
fast: false
modifier: MODEL1310110010#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
product: MODEL1310110010#
reactant: MODEL1310110010#
name: L-carnitine reversible transport
type: Reaction
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_88c30713_62f9_4f19_b48e_8319a35e94db
is: P19440
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: GGT1
is encoded by: hsa:2678
type: Species
is: SBO:0000252
has only substance units: false

metaR UMPK
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase
modifier: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_9d36f06f_0c65_4ec7_9775_dbe6a8d6078d
is encoded by: hsa:6391
is encoded by: hsa:6389
initial concentration: NaN
has part: P31040
is encoded by: hsa:6392
has part: O14521
is: SBO:0000297
name: SDHA:SDHB:SDHC:SDHD
constant: false
is encoded by: hsa:6390
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
has part: P21912
has part: Q99643

metaR r0735
kinetic law: MODEL1310110010#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
modifier: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
reactant: MODEL1310110010#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaR SCPx
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.176
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
name: peroxisomal thiolase 2
type: Reaction

metaR r1626
reversible: true
kinetic law: MODEL1310110010#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000000

metaR FAOXC200180x
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
reactant: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_fc54e321_c29c_424a_9409_e5255e9c159d
is: Q9Y673
initial amount: NaN
has only substance units: false
type: Species
name: ALG5
initial concentration: NaN
is encoded by: hsa:29880
boundary condition: true
constant: false
is: SBO:0000252

metaM 3hpcoa m
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: HMDB06807
boundary condition: false
is: CHEBI:58528
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 3-hydroxypropanoyl-CoA(4-)

metaR PE HStm
kinetic law: MODEL1310110010#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110010#
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110010#
is: SBO:0000185

metaR TYMSULT
name: Tyramine Sulfotransferase
modifier: MODEL1310110010#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.1
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_bf61b378_324d_4957_b379_38d1a3ba96cd
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ACSS2
type: Species
is encoded by: hsa:55902
is: Q5QPH3
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_1671fc00_c0da_4ea2_b46a_c5e006e532b7
is: Q9NPC4
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:53947
initial concentration: NaN
name: A4GALT

http://identifiers.org/biomodels.db/MODEL1310110010#_d3c9e99f_14fa_491f_a332_2fb9de34ec5f
initial concentration: NaN
boundary condition: true
has only substance units: false
is: D3DX95
initial amount: NaN
constant: false
name: CHAT
is: SBO:0000252
type: Species
is encoded by: hsa:1103

metaM pe hs e
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16038
has only substance units: false
is: SBO:0000247
name: phosphatidylethanolamine
boundary condition: false
type: Species

metaR r2313
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110010#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false

metaM cmpacna c
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
initial amount: NaN

metaR r2538
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Utilized transport
reactant: MODEL1310110010#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: true

metaM btcoa c
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: CHEBI:57371
initial amount: NaN
constant: false
is: C00136
has only substance units: false
initial concentration: 1.0
is: HMDB01088
is: SBO:0000247
type: Species
boundary condition: false
name: Butanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110010#_e5a61b89_a072_41b5_a759_cd96106a7cee
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:R14373
name: _R14373_1_x

metaR UDPDOLPT U
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
is: SBO:0000176
product: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.117
fast: false

metaM ppcoa c
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB01275
is: CHEBI:57392
initial amount: NaN
name: Propanoyl-CoA
type: Species
is: C00100
has only substance units: false

metaR r1627
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is described by: ECO:0000000

metaR S6T12g
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
type: Reaction

metaM pro L e
boundary condition: false
is: CHEBI:17203
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
type: Species

metaR ACACt2m
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
reversible: true
fast: false
is described by: ECO:0000269
name: Acetoacetate mitochondrial transport via H+ symport
modifier: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185

metaR OXAtp
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
is: SBO:0000185
name: oxalate transport out of peroxisome
reactant: MODEL1310110010#

metaM thr L e
initial amount: NaN
type: Species
constant: false
is: HMDB00167
has only substance units: false
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: SBO:0000247
initial concentration: 1.0
name: L-threonine
is: CHEBI:16857

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR r1560
kinetic law: MODEL1310110010#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
reactant: MODEL1310110010#

metaM HC00361 c
name: sedoheptulose 1,7-bisphosphate(4-)
initial amount: NaN
type: Species
is: CHEBI:58335
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447

http://identifiers.org/biomodels.db/MODEL1310110010#_3bbfa62f_a002_483d_9c59_7f824d0f968b
boundary condition: true
is: Q8NFL0
has only substance units: false
initial concentration: NaN
name: B3GNT7
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:93010
initial amount: NaN

metaR RNDR4
reactant: MODEL1310110010#
name: ribonucleoside-diphosphate reductase (UDP)
type: Reaction
fast: false
kinetic law: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is: SBO:0000176
is described by: ECO:0000254
modifier: MODEL1310110010#

metaM tetpent6 e
initial concentration: 1.0
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: HMDB06322
name: tetracosapentaenoic acid, n-6
constant: false

metaR RE3243R
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
type: Reaction
product: MODEL1310110010#
is described by: ECO:0000000
name: RE3243
is: SBO:0000176
reversible: true
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_7cc858f0_d34b_4e3f_85e7_0a87a6198fc6
initial amount: NaN
is: SBO:0000252
is: Q6NVY1
is encoded by: hsa:26275
boundary condition: true
type: Species
constant: false
name: HIBCH
initial concentration: NaN
has only substance units: false

metaR ABUTt2r
is: SBO:0000185
kinetic law: MODEL1310110010#
name: 4-aminobutyrate reversible transport in via proton symport
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r

metaR r2539
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
fast: false
name: Postulated transport reaction
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR r2312
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
product: MODEL1310110010#

metaR DGULND
fast: false
reactant: MODEL1310110010#
name: dehydro-L-gulonate decarboxylase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR r1628
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000

metaR ARACHDtr
fast: false
is: SBO:0000185
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction
name: intracellular transport

metaM HC02187 e
initial concentration: 1.0
name: reverse-triiodthyronine
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:28774
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

metaM ksi pre33 g
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 33
constant: false
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
type: Species
is: C00130
is: HMDB00175
initial concentration: 1.0
is: CHEBI:58053
initial amount: NaN
has only substance units: false

metaR CITtam
kinetic law: MODEL1310110010#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110010#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
fast: false
product: MODEL1310110010#
name: citrate transport, mitochondrial
reactant: MODEL1310110010#

metaM ha deg1 l
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C22H33N2O16 CHARGE: -1
initial amount: NaN
has only substance units: false
is: CHEBI:16336
type: Species
constant: false
is: SBO:0000247
name: hyaluronan degradation product 1

http://identifiers.org/biomodels.db/MODEL1310110010#_e4072fc9_226e_41ff_86a5_e301f95c2ed7
type: Species
name: NDUFA7
constant: false
boundary condition: true
is: Q6FG42
initial amount: NaN
is encoded by: hsa:4701
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM dd2coa x
has only substance units: false
type: Species
name: trans-Dodec-2-enoyl-CoA
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:57330
is: SBO:0000247
is: HMDB03712

metaR S6T8g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
modifier: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is: SBO:0000176

metaR KHte
kinetic law: MODEL1310110010#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: KHte
is: SBO:0000185
reversible: true
product: MODEL1310110010#
is described by: ECO:0000134
reactant: MODEL1310110010#

metaM mma c
is: SBO:0000247
name: methylammonium
notes: FORMULA: C1H6N CHARGE: 1 INCHI: InChI=1S/CH5N/c1-2/h2H2,1H3/p+1 EHMN_ABBREVIATION: C00218
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00164
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:59338

metaR HPACtr
kinetic law: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
name: hydroxyphenylacetate transport via diffusion
fast: false
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
reversible: true
is described by: ECO:0000000

metaM m7masnC g
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C64H107N2O50X CHARGE: 0
is: CHEBI:58282
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00968
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
type: Species

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM pro L c
is: HMDB00162
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:17203
has only substance units: false
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial amount: NaN
name: L-proline
is: SBO:0000247

metaR r1629
reversible: true
is: SBO:0000185
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110010#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR DPCOAPPe
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#
fast: false
name: Pyrophasphatase (dephospho-CoA, extracellular)
reversible: false
reactant: MODEL1310110010#

metaR r2311
is described by: ECO:0000000
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
reversible: true

metaM saccrp L m
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
constant: false
initial amount: NaN
is: CHEBI:57951
name: L-saccharopinate(1-)
initial concentration: 1.0
type: Species
is: HMDB00279

metaR FATP3t
reactant: MODEL1310110010#
name: fatty acid electroneutral transport
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000185
modifier: MODEL1310110010#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_b28ab033_46c5_4eca_8a36_0ce47e526228
type: Species
constant: false
boundary condition: true
name: PLD2
is: SBO:0000252
is encoded by: hsa:5338
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: O14939

metaR RE3520E
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.9
fast: false
name: RE3520
is described by: ECO:0000000
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_7a6e89ce_b794_410a_a3d6_ced6fd1bcb18
has only substance units: false
is encoded by: hsa:6524
initial amount: NaN
constant: false
name: SLC5A2
is: P31639
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_03bf9866_70ec_4599_8370_3d0a5cb1db0b
is: SBO:0000252
name: GPX1
initial concentration: NaN
constant: false
is encoded by: hsa:2876
is: P07203
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_0b03856e_6136_4c47_ae2a_332059ae2445
is: SBO:0000252
constant: false
is encoded by: hsa:53354
type: Species
initial amount: NaN
has only substance units: false
name: PANK1
initial concentration: NaN
boundary condition: true

metaR r0731
reversible: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_2257d5fc_ebc4_48fa_b114_2638c9f09c47
is encoded by: hsa:3939
boundary condition: true
initial concentration: NaN
name: LDHA
is: SBO:0000252
type: Species
has only substance units: false
is: P00338
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_e5c338f1_5f6b_44d2_a54a_5f2faad5b2f2
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:2766
initial amount: NaN
has only substance units: false
name: GMPR
is: P36959

http://identifiers.org/biomodels.db/MODEL1310110010#_c4281071_b96f_4403_a0c6_6ece2447e174
type: Species
name: DGKD
initial concentration: NaN
is encoded by: hsa:8527
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR NORANMT
type: Reaction
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (5409.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
is: SBO:0000176
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.28
name: noradrenaline N-methyltransferase
modifier: MODEL1310110010#
is described by: ECO:0000269

metaR r2318
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#

metaM arachcrn c
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: arachidyl carnitine
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: HMDB06460
boundary condition: false
initial amount: NaN

metaR TETPENT3COAtx
fast: false
name: fatty acid intracellular transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110010#_a0a213be_cdd7_47df_bcf9_3f756486f4a4
initial concentration: NaN
name: _AI469183_1_x
is: SBO:0000252
type: Species
is encoded by: hsa:AI469183
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_3f261e52_e4a8_41f1_9a3a_02973a4e9775
initial concentration: NaN
initial amount: NaN
type: Species
name: SLC25A14
is encoded by: hsa:9016
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

metaM crn m
type: Species
initial amount: NaN
name: L-Carnitine
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
boundary condition: false
is: HMDB00062
has only substance units: false
constant: false
initial concentration: 1.0
is: C00318

metaM pa hs c
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: phosphatidate(2-)
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739

metaM r1p c
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: alpha-D-Ribose 1-phosphate
has only substance units: false
type: Species
is: HMDB01489
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: C00442
is: CHEBI:57720
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_cd486ac0_a688_4bfc_a1c3_eb6f1f2f0b25
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA532636
name: _AA532636_1_m
type: Species
initial amount: NaN

metaR r1569
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110010#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_78bd0b33_e37c_4a2e_a8ee_bbcdb2533f04
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:23236
is: Q9NQ66
is: SBO:0000252
type: Species
name: PLCB1
initial concentration: NaN

metaM pail5p hs n
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaR r0732
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction

metaR PECTCHLe
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of pectins with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR KSII CORE2tly
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
name: keratan sulfate II (core 2) transport, extracellular to lysosome
product: MODEL1310110010#
fast: false
is: SBO:0000185
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_b331fb47_1551_4d1d_b922_cf43b5eaa07f
initial concentration: NaN
is: P09848
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:3938
is: SBO:0000252
name: LCT
constant: false

metaM thbpt4acam n
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false
is: HMDB02281
type: Species
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:15374
initial amount: NaN
constant: false

metaR r2317
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_dc77e53d_2bab_4a3a_8fe0_0842228a47c2
name: CTPS2
is: Q9NRF8
is encoded by: hsa:56474
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

metaM HC02206 c
name: prostaglandin C1(1-)
type: Species
is: CHEBI:57399
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_438f31ff_c0a9_4ce0_86c9_730f8a0c62d6
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:LOC374569
name: _LOC374569_1_e

metaM cmpacna g
is: HMDB01176
constant: false
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57812

metaR G14T16g
product: MODEL1310110010#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_a92be771_9adc_4ce6_afe6_75d2eba6a38b
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA576959
name: _AA576959_1_c
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaM 4ppcys c
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01117
constant: false
is: CHEBI:59458
is: C04352
initial concentration: 1.0
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine

metaM arachcoa c
constant: false
name: arachidyl coenzyme A
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: HMDB04258
is: CHEBI:15527

http://identifiers.org/biomodels.db/MODEL1310110010#_ddddaa43_29b5_462e_9160_1de61a29ec03
name: PEMT
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:10400
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9UBM1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_6fc17d6f_c2f9_4cdb_9b8d_913a876a2741
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1491
has only substance units: false
is: SBO:0000252
is: P32929
name: CTH

metaM dhlam m
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: dihydrolipoamide
is: HMDB00985
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17694

metaR ACALDt
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
reversible: true
name: acetaldehyde reversible transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR r0733
modifier: MODEL1310110010#
is: SBO:0000176
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_37009b39_75bf_48aa_838f_8d0c0698a77b
is: SBO:0000252
type: Species
is: Q92604
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:9926
initial amount: NaN
name: LPGAT1
has only substance units: false

metaM retinal cis 13 r
initial concentration: 1.0
is: SBO:0000247
name: 13-cis-retinal
constant: false
is: HMDB06220
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: CHEBI:45487

metaR AKR1D2
reversible: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
product: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.1.3
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110010#
is described by: ECO:0000269

metaR r2399
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
reversible: false
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
kinetic law: MODEL1310110010#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_41100845_c5f1_41db_add5_90c83ab3d873
boundary condition: true
name: SLC5A12
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: Q1EHB4
is: SBO:0000252
is encoded by: hsa:159963
has only substance units: false

metaM xoldioloneh c
initial amount: NaN
is: SBO:0000247
is: CHEBI:2288
has only substance units: false
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
is: HMDB06887
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_3bb2d93f_ee48_4d4c_9420_cbf420fc315b
type: Species
boundary condition: true
is: B1AK53
is encoded by: hsa:83715
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: ESPN
initial amount: NaN

metaR r2316
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR PAIL4P HStn
is described by: ECO:0000000
reversible: true
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110010#
is: SBO:0000185

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR DCK1n
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
fast: false
is: SBO:0000176
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
reversible: true
modifier: MODEL1310110010#
name: Deoxycytidine kinase, nuclear (ATP)
is described by: ECO:0000269

metaR B MANNASEly
is: SBO:0000176
modifier: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
name: beta-mannosidase, lysosomal
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.25
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_c7e57bdb_e0db_4dc9_b362_9f6bdc8ae093
constant: false
boundary condition: true
initial concentration: NaN
name: SLC35D2
initial amount: NaN
is encoded by: hsa:11046
is: Q76EJ3
type: Species
is: SBO:0000252
has only substance units: false

metaM ppcoa m
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57392
name: Propanoyl-CoA
type: Species
is: SBO:0000247
is: C00100
is: HMDB01275
has only substance units: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_9dce24ed_4969_4490_a388_d8aeb37fe436
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: H6PD
is encoded by: hsa:9563
boundary condition: true
is: O95479

metaM gal l
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
type: Species
is: HMDB00143
has only substance units: false
name: D-galactose
initial amount: NaN
boundary condition: false

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM 4mzym int1 r
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06927
name: 4-Methylzymosterol intermediate 1
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
constant: false

metaR r0734
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110010#
type: Reaction
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_449c0d09_8de7_4341_8623_a97d3a8e2669
type: Species
is encoded by: hsa:5334
name: PLCL1
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q15111

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaM ksi pre25 g
boundary condition: false
constant: false
type: Species
has only substance units: false
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: HMDB00175
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 25
is: CHEBI:58053
is: C00130
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_934e7a8c_c5f1_474f_82fe_97643d3e170a
is: SBO:0000252
name: NOS3
is: A0S0A7
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:4846
initial amount: NaN
type: Species
boundary condition: true

metaR r2315
product: MODEL1310110010#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaR AG13T3g
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110010#
reversible: false
product: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is: SBO:0000176

metaR RNDR1
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (ADP)
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000254
reversible: false
modifier: MODEL1310110010#

metaR TETHEX3t
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is: SBO:0000185
name: fatty acid transport via diffusion
reactant: MODEL1310110010#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_84ba3106_970b_4252_8b31_863ffc656ab6
is: P09669
is encoded by: hsa:1345
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: COX6C
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_2304293c_b060_483a_bc93_44df7329d41c
has only substance units: false
type: Species
is: SBO:0000252
name: ST3GAL3
is: B4DX62
is encoded by: hsa:6487
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_b8ddbf7e_a819_4e51_9386_3146ee827f59
boundary condition: true
name: SPHK2
is encoded by: hsa:56848
constant: false
initial amount: NaN
is: Q9NRA0
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_1b29d816_d971_4423_b48e_2f3ba761b6ec
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:6817
has only substance units: false
name: SULT1A1
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM dttp c
boundary condition: false
name: dTTP
is: C00459
type: Species
is: CHEBI:37568
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
is: HMDB01342
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_2d034024_91e0_403f_b779_7570020a3b69
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: PGK2
initial concentration: NaN
is encoded by: hsa:5232
is: P07205
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_89638683_f403_476b_87f2_ec94cebdfe8d
is: B2RAT6
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: GALT
is encoded by: hsa:2592
initial amount: NaN
type: Species
is: SBO:0000252

metaM cholate r
notes: FORMULA: C24H39O5 CHARGE: -1 INCHI: InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
boundary condition: false
initial amount: NaN
name: cholate
is: HMDB00619
initial concentration: 1.0
is: CHEBI:29747
is: SBO:0000247
constant: false
has only substance units: false

metaR r2471
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.18.8.1
is: SBO:0000185
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#

metaM i c
type: Species
is: CHEBI:16382
boundary condition: false
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: HMDB12238
has only substance units: false
name: iodide
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR GALASE15ly
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
type: Reaction
product: MODEL1310110010#
reversible: false
fast: false
reactant: MODEL1310110010#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM ksi deg23 l
is: CHEBI:12936
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 23
type: Species
is: SBO:0000247
is: HMDB00143
constant: false
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
initial amount: NaN

metaR AHCYStr
kinetic law: MODEL1310110010#
name: S-Adenosyl-L-homocysteine intracellular diffusion
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000000

metaR r1566
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_bccfd533_3ae8_4baf_8341_c96fe99f7a7c
boundary condition: true
initial amount: NaN
constant: false
is: Q16348
has only substance units: false
type: Species
initial concentration: NaN
name: SLC15A2
is: SBO:0000252
is encoded by: hsa:6565

http://identifiers.org/biomodels.db/MODEL1310110010#_089f2b53_936a_43b6_9653_7decca91e23d
is encoded by: hsa:3073
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: HEXA
is: P06865
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r1453
is: SBO:0000176
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
reversible: true
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR NRPPHRtu
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110010#
reversible: true
name: Norepinephrine uniport
reactant: MODEL1310110010#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM CE4791 x
notes: FORMULA: C41H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-30,34-36,40,49,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t29-,30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4791
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12947
name: 3(S)-hydroxy-dihomo-gama-linolenoyl-CoA
has only substance units: false
constant: false
type: Species
is: SBO:0000247

metaM dd2coa m
name: trans-dodec-2-enoyl-CoA(4-)
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB03712
is: CHEBI:57330
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221

metaM pristcoa x
initial concentration: 1.0
name: pristanoyl coa
constant: false
boundary condition: false
is: CHEBI:51341
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2

http://identifiers.org/biomodels.db/MODEL1310110010#_57c628ce_105b_4da1_9946_ed9349ac10b9
is: SBO:0000252
initial amount: NaN
is: P49189
boundary condition: true
constant: false
is encoded by: hsa:223
type: Species
name: ALDH9A1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_9e327b61_68fe_4e58_9ce6_d5b647d8df34
constant: false
is: B2RD24
initial amount: NaN
type: Species
name: MTHFD1L
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:25902

metaR DHORTS
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.3.2
name: dihydroorotase
modifier: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_4203161d_b0ad_455b_9cce_d8f5d41a1c35
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is: P08842
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:412
name: STS

metaM ksii core2 deg8 l
is: HMDB00143
type: Species
name: keratan sulfate II (core 2-linked), degradation product 8
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0
has only substance units: false

metaR r1167
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176
type: Reaction
name: EC:2.3.1.26
product: MODEL1310110010#

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_6e7dbbcd_77b6_43bd_9f83_3ab2e83559b0
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:79966
name: SCD5
has only substance units: false
is: Q86SK9
initial concentration: NaN
type: Species
boundary condition: true

metaM ksi pre7 g
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
type: Species
is: C00130
notes: FORMULA: C115H187N8O85SX CHARGE: -2
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 7

metaR BTNtn
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
fast: false
name: Biotin transport, nuclear
reactant: MODEL1310110010#
reversible: true

metaM 25hvitd3 e
initial amount: NaN
constant: false
is: SBO:0000247
name: calcidiol
has only substance units: false
initial concentration: 1.0
is: HMDB03550
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
is: CHEBI:17933
type: Species
boundary condition: false

metaM fucgalacglcgalgluside hs g
boundary condition: false
constant: false
is: HMDB01263
type: Species
is: CHEBI:17917
name: Type IH glycolipid
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_8647da46_3a13_49de_a2f6_396cfc6996ca
is: P21912
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: SDHB
constant: false
is encoded by: hsa:6390
is: SBO:0000252
initial concentration: NaN

metaM pro L m
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
is: HMDB00162
type: Species
is: SBO:0000247
is: CHEBI:17203

metaR r1565
reactant: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110010#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110010#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_2c2d1a5b_779c_4cfb_a932_cf29ec2b4a0e
boundary condition: true
is: P14060
name: HSD3B1
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3283
constant: false
type: Species

metaR PTPAT
product: MODEL1310110010#
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.7.3
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110010#
reversible: true
is: SBO:0000176
fast: false

metaM HC00342 c
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
name: cis-aconitate(3-)
is: CHEBI:16383
is: SBO:0000247
initial concentration: 1.0

metaM pe hs m
initial amount: NaN
name: phosphatidylethanolamine
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
has only substance units: false
type: Species
is: CHEBI:16038
is: SBO:0000247
constant: false

metaR DOLPGT2 Uer
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110010#
fast: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.265
type: Reaction
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_033a1a6b_0c2e_4f65_96d5_025a16401d66
initial concentration: NaN
has only substance units: false
is: E2QC23
is encoded by: hsa:23464
boundary condition: true
type: Species
name: GCAT
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_4b6e68c4_5d93_46c3_89c4_beb1ff27cf15
has only substance units: false
is: Q5T4W8
initial concentration: NaN
is encoded by: hsa:6487
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ST3GAL3
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_07ff5dc3_4f1f_4f9e_b658_7438e465322d
name: ESCO1
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:114799
is: Q5FWF5
is: SBO:0000252

metaM HC01115 c
is: CHEBI:29025
type: Species
is: SBO:0000247
initial concentration: 1.0
name: NeuNGc
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410

metaR GLYCLTtp
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
product: MODEL1310110010#
fast: false
name: glycolate transport into peroxisome
kinetic law: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_e51cb83b_5b41_410b_aa4b_8a2d71294c23
boundary condition: true
type: Species
is: P22413
initial amount: NaN
is encoded by: hsa:5167
name: ENPP1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

metaM dolmanp U r
is: CHEBI:15809
initial concentration: 1.0
name: Dolichyl phosphate D-mannose, human uterine homolog
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1

metaR r1568
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR GALASE5ly
fast: false
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110010#
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110010#_82f523cf_e7c0_48e8_8c66_b59611d0db15
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:NOS2A
initial amount: NaN
name: _NOS2A_1_e
boundary condition: true
initial concentration: NaN

metaR FAOXC200180m
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176

metaR UGLCNACtg
reversible: true
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
fast: false
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110010#
name: UDP-GlcNAc Golgi transport via CMP antiport
type: Reaction
modifier: MODEL1310110010#
product: MODEL1310110010#

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR F1PGT
fast: false
reversible: true
reactant: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
name: fucose-1-phosphate guanylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.30

metaM HC01401 x
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: SBO:0000247
is: CHEBI:27668

http://identifiers.org/biomodels.db/MODEL1310110010#_3200964f_8a20_4079_b7f7_c90aa919dd71
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: RRM2
is: P31350
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:6241

metaM 5dhf e
initial concentration: 1.0
initial amount: NaN
name: pentaglutamyl folate (DHF)
is: SBO:0000247
is: HMDB06487
type: Species
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
constant: false
has only substance units: false
boundary condition: false

metaM 25hvitd3 c
is: SBO:0000247
is: HMDB03550
boundary condition: false
is: CHEBI:17933
initial amount: NaN
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
initial concentration: 1.0
type: Species
constant: false
name: calcidiol
has only substance units: false

metaM glyclt c
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: glycolate
has only substance units: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: HMDB00115
is: CHEBI:29805
initial amount: NaN
initial concentration: 1.0

metaR r0730
fast: false
is: SBO:0000176
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false

metaM galacglcgalgluside hs g
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: Lc4Cer
initial amount: NaN
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: CHEBI:17103

metaM crn e
constant: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
initial amount: NaN
is: C00318
is: HMDB00062
name: L-Carnitine
is: CHEBI:16347
boundary condition: false

metaR r1567
reversible: true
kinetic law: MODEL1310110010#
is: SBO:0000185
fast: false
product: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
is described by: ECO:0000000

metaR r1454
type: Reaction
fast: false
reversible: false
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:

metaM amet r
name: S-adenosyl-L-methionine
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
has only substance units: false
is: CHEBI:15414
is: SBO:0000247
is: HMDB01185
constant: false

metaR ACCOAtn
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: acetyl-CoA transport, nuclear
reversible: true
type: Reaction
fast: false

metaM nrpphrsf c
initial amount: NaN
name: Sulfate derivative of norepinephrine
constant: false
type: Species
initial concentration: 1.0
is: HMDB02062
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: http://identifiers.org/pubchem.compound/123747

http://identifiers.org/biomodels.db/MODEL1310110010#_d400b597_f6fa_45dc_84af_901e528220c6
constant: false
is: P11310
is: SBO:0000252
boundary condition: true
name: ACADM
is encoded by: hsa:34
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_f83995fb_3b3f_4a74_ab87_ec8c08a29946
is: SBO:0000252
name: SLC16A1
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6566
is: B4DKS0
initial amount: NaN
type: Species

metaR INSTt4
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
name: inositol transport via sodium symport
is: SBO:0000185
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
modifier: MODEL1310110010#
is described by: ECO:0000269
reversible: true

metaR THBPT4ACAMDASE
kinetic law: MODEL1310110010#
fast: false
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
modifier: MODEL1310110010#
product: MODEL1310110010#
reversible: false
is: SBO:0000176
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction

metaR CYTK4n
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
modifier: MODEL1310110010#
reversible: true
name: cytidylate kinase (dCMP,GTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269

metaM ppi c
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3
constant: false
is: C00013
is: CHEBI:0
type: Species
is: HMDB00250
initial concentration: 1.0
is: SBO:0000247
name: Diphosphate
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_cd068dee_86ff_4d19_ad3f_7ad04e20d43c
boundary condition: true
has only substance units: false
constant: false
name: _AI631997_1_m
is encoded by: hsa:AI631997
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_12b4bbb4_eed8_478c_bf0f_2b8d016c7220
name: SLC6A7
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6534
is: Q99884
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

metaR r2319
fast: false
kinetic law: MODEL1310110010#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110010#
product: MODEL1310110010#
reversible: true
is described by: ECO:0000000

metaR r2532
is described by: ECO:0000000
product: MODEL1310110010#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM h2o2 e
type: Species
constant: false
is: CHEBI:16240
has only substance units: false
is: HMDB03125
boundary condition: false
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
initial amount: NaN
name: hydrogen peroxide

metaM fmn c
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: SBO:0000247
name: FMN
is: C00061
has only substance units: false
is: CHEBI:58210
is: HMDB01520
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaR DNDPt35m
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110010#
name: dGDP transport via dADP antiport
is described by: ECO:0000269
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
reversible: false
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_22352847_7503_46c8_8db5_fcfb4a05868e
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1349
boundary condition: true
name: COX7B
type: Species
initial amount: NaN
constant: false
is: P24311

http://identifiers.org/biomodels.db/MODEL1310110010#_7ca75875_ef6b_41c0_ab4b_548c2c15f1b5
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23600
name: AMACR
type: Species
has only substance units: false
is: Q3KT79
constant: false
initial amount: NaN

metaR RE2658R
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000
reversible: true
name: RE2658
product: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM gdp c
has only substance units: false
type: Species
constant: false
boundary condition: false
is: HMDB01201
name: GDP
is: CHEBI:58189
initial amount: NaN
is: C00035
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_20e64143_8cb2_4c31_a858_11138a290f9e
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is: P49902
is encoded by: hsa:22978
constant: false
name: NT5C2

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM itacon m
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
type: Species
is: CHEBI:17240
is: HMDB02092
initial amount: NaN
boundary condition: false
has only substance units: false
name: itaconate(2-)
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR ST8SIA11
is: SBO:0000176
name: Beta-galactoside alpha-2,3-sialyltransferase
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.8
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR HDCEAtr
name: fatty acid transport via diffusion
is: SBO:0000185
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true

metaR FAOXC161802m
modifier: MODEL1310110010#
fast: false
product: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
type: Reaction
name: Beta oxidation fatty acid
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false

metaM ksi deg18 l
is: CHEBI:12936
is: SBO:0000247
boundary condition: false
name: keratan sulfate I, degradation product 18
initial amount: NaN
constant: false
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
is: HMDB00143
has only substance units: false
initial concentration: 1.0
type: Species

metaR r2080
reactant: MODEL1310110010#
fast: false
reversible: true
product: MODEL1310110010#
modifier: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM f6p c
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3385
constant: false
is: CHEBI:57579
name: D-Fructose 6-phosphate
is: HMDB00124
is: C00085
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r0456
is described by: ECO:0000000
fast: false
modifier: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.1.32
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
product: MODEL1310110010#
kinetic law: MODEL1310110010#
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
type: Reaction

metaR RE1521M
name: RE1521
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110010#_6158c8a4_939e_48e3_aed5_f750fea334e0
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: Q15738
name: NSDHL
is encoded by: hsa:50814
is: SBO:0000252
initial amount: NaN
type: Species

metaM hdca e
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Hexadecanoate (n-C16:0)
boundary condition: false
type: Species
is: CHEBI:0
is: HMDB00220
initial concentration: 1.0
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1
is: C00249

metaM oh1 c
initial concentration: 1.0
notes: FORMULA: HO CHARGE: -1
type: Species
name: hydroxide ion
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01039
is: C01328
boundary condition: false
has only substance units: false

metaR SCP2x
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110010#
name: peroxisomal thiolase 2
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000176
product: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ
kinetic law: MODEL1310110010#
fast: false

metaR r0788
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR NACHEX27ly
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110010#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_3f21aaca_f8a1_4833_a741_3f82af6dfb81
is encoded by: hsa:84129
constant: false
is: SBO:0000252
initial concentration: NaN
name: ACAD11
boundary condition: true
type: Species
is: Q709F0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_e305ee61_19b9_4f8c_998b_6f5fa57149a0
type: Species
is: Q9BV79
name: MECR
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:51102

http://identifiers.org/biomodels.db/MODEL1310110010#_fe8279a8_d66b_4d1d_b492_d3fbfefb227e
has only substance units: false
constant: false
boundary condition: true
is: Q9NS00
name: C1GALT1
initial amount: NaN
type: Species
is encoded by: hsa:56913
initial concentration: NaN
is: SBO:0000252

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_69dfd48f_4b03_4dcf_9b1e_25362b4f2489
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: _AI378339_1_m
boundary condition: true
has only substance units: false
is encoded by: hsa:AI378339

metaM 10fthf e
boundary condition: false
is: SBO:0000247
constant: false
name: 10-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00972
is: CHEBI:57454
initial amount: NaN

metaM aacoa m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: acetoacetyl-CoA(4-)
is: HMDB01484
is: CHEBI:57286
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

metaR AACTOOR
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
type: Reaction
name: Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
product: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (8639.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:10328770,PMID:12878330 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.21

metaR XOL7AH2tm
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
is described by: ECO:0000000
product: MODEL1310110010#

metaR GALASE6ly
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110010#

metaR r0517
kinetic law: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
product: MODEL1310110010#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:

metaM prostge2 e
has only substance units: false
type: Species
name: prostaglandin E2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
is: SBO:0000247
is: CHEBI:606564
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01220

http://identifiers.org/biomodels.db/MODEL1310110010#_c60c85ef_250c_4e32_8def_411bf4028072
name: CMPK1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: B2R6S5
is encoded by: hsa:51727
constant: false
type: Species
has only substance units: false

metaR MCITS
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
reversible: false
product: MODEL1310110010#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: 2-methylcitrate synthase
type: Reaction
kinetic law: MODEL1310110010#

metaR r2081
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_b25ecdb3_fc70_4a8e_878b_bc5c46736ec7
is encoded by: hsa:AW277253
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: _AW277253_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r0787
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
type: Reaction
is: SBO:0000176
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is described by: ECO:0000000
modifier: MODEL1310110010#

metaR UAGDP
kinetic law: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.23
is described by: ECO:0000269
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
type: Reaction
product: MODEL1310110010#
name: UDP-N-acetylglucosamine diphosphorylase
fast: false
is: SBO:0000176
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_beb5e542_a0d5_46a0_a2c6_978693f75baf
has only substance units: false
name: LGSN
boundary condition: true
initial amount: NaN
type: Species
is: Q5TDP6
is encoded by: hsa:51557
initial concentration: NaN
constant: false
is: SBO:0000252

metaM ala L m
is: HMDB00161
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: L-alanine
boundary condition: false
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
constant: false
is: SBO:0000247

metaM ttdca e
initial concentration: 1.0
constant: false
is: HMDB00806
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
name: tetradecanoate (n-C14:0)
is: SBO:0000247
is: C06424
has only substance units: false
type: Species
is: CHEBI:30807
boundary condition: false
initial amount: NaN

metaM fmn e
constant: false
is: HMDB01520
boundary condition: false
is: CHEBI:58210
name: FMN
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C00061
type: Species
notes: FORMULA: C17H19N4O9P CHARGE: -2
has only substance units: false

metaR FUT12g
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.69
type: Reaction
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
modifier: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
is: SBO:0000176
name: Galactoside 2-alpha-L-fucosyltransferase 1
fast: false
is described by: ECO:0000269

metaM h2o2 c
type: Species
boundary condition: false
constant: false
is: CHEBI:16240
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
is: SBO:0000247
name: Hydrogen peroxide
is: C00027
initial amount: NaN
has only substance units: false

metaM thcholstoic c
type: Species
is: CHEBI:18402
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
initial amount: NaN
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

http://identifiers.org/biomodels.db/MODEL1310110010#_ca6ec0e6_4712_44b6_b370_09c90ffcc11e
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6568
constant: false
name: SLC17A1
has only substance units: false
is: Q14916
initial amount: NaN

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM nadph c
type: Species
is: C00005
initial concentration: 1.0
is: HMDB00221
is: SBO:0000247
has only substance units: false
is: CHEBI:57783
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
name: Nicotinamide adenine dinucleotide phosphate - reduced

http://identifiers.org/biomodels.db/MODEL1310110010#_4880593a_2d07_49cd_b48d_04c0ce5eae96
is encoded by: hsa:4831
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: NME2
is: P22392
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_73a522f4_71b6_4099_b202_23aabf00f6fc
name: SLC23A2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:9962
is: Q9UGH3
has only substance units: false

metaM acac e
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:13705
name: acetoacetate
is: HMDB00060

metaM ksii core4 pre4 g
is: HMDB00175
boundary condition: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 4
initial concentration: 1.0
is: CHEBI:58053
type: Species
is: C00130
constant: false
initial amount: NaN
notes: FORMULA: C61H99N5O43X CHARGE: -1

metaM adrncoa c
initial amount: NaN
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
constant: false

metaM ksii core2 deg9 l
notes: FORMULA: C30H50N3O20X CHARGE: 0
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00143
constant: false
has only substance units: false
type: Species
name: keratan sulfate II (core 2-linked), degradation product 9
is: CHEBI:12936

metaM lgt S c
constant: false
is: HMDB01066
name: (R)-S-lactoylglutathionate(1-)
is: CHEBI:57474
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
type: Species
has only substance units: false
is: SBO:0000247

metaM oh1 e
name: hydroxide ion
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: C01328
has only substance units: false
constant: false
notes: FORMULA: HO CHARGE: -1
is: HMDB01039

metaM g6p c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: HMDB01401
boundary condition: false
has only substance units: false
name: D-Glucose 6-phosphate
is: CHEBI:61548
constant: false
initial concentration: 1.0
type: Species
is: C00092

metaM hdca c
initial amount: NaN
is: CHEBI:7896
name: palmitate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
type: Species
initial concentration: 1.0
is: HMDB00220
constant: false
has only substance units: false

metaR r2330
reactant: MODEL1310110010#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_52a1b6a6_e5de_4bf5_8598_2fe6a97a7926
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8854
type: Species
name: ALDH1A2
boundary condition: true
initial concentration: NaN
is: B4DZR2
constant: false
initial amount: NaN

metaM itp n
initial amount: NaN
is: HMDB00189
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
name: ITP(3-)
constant: false
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0

metaR r2082
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110010#
modifier: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_dac06168_c08b_4b2c_a283_cc4ee2d469be
is: SBO:0000252
is: Q38G75
is encoded by: hsa:2582
boundary condition: true
constant: false
name: GALE
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR r0390
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
is: SBO:0000176
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
type: Reaction
reactant: MODEL1310110010#

metaM glyc3p c
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:57597
initial concentration: 1.0
name: Glycerol 3-phosphate
is: HMDB00126
is: C00093
type: Species

metaM alpam m
initial amount: NaN
type: Species
name: S-aminomethyldihydrolipoamide
is: HMDB06239
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
is: SBO:0000247
constant: false
boundary condition: false

metaM arachdcrn x
type: Species
is: SBO:0000247
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01064
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
name: C20:4 carnitine

metaM sql r
boundary condition: false
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: squalene
is: HMDB00256
is: SBO:0000247
is: CHEBI:15440

metaR SUCCTD
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_500e3fcc_07c0_4373_9499_02f29ef51e25
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10965
constant: false
is: P49753
initial amount: NaN
initial concentration: NaN
name: ACOT2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_e33d9e27_14bb_45c0_8f36_f32aa610c6eb
name: ALDH3B1
is: SBO:0000252
is: P43353
constant: false
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:221
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_4d85bf82_f64e_42e6_b822_9efab3c46bb9
initial amount: NaN
is encoded by: hsa:80347
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: COASY
has only substance units: false
is: Q13057

metaR SO4OXAtex2
modifier: MODEL1310110010#
fast: false
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
name: sulfate transport via oxalate countertransport (2:1)
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110010#

metaM sucsal m
boundary condition: false
is: HMDB01259
is: SBO:0000247
is: CHEBI:57706
name: Succinic semialdehyde
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false

metaM dudp c
boundary condition: false
name: dUDP
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: C01346
is: SBO:0000247
is: HMDB01000
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: CHEBI:60471

metaM ttdca c
initial amount: NaN
constant: false
is: HMDB00806
has only substance units: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
name: myristate
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:30807

metaM ins e
is: CHEBI:17596
is: HMDB00195
boundary condition: false
has only substance units: false
name: Inosine
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
type: Species
is: C00294
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r0789
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
product: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_91982768_93be_41ce_bcaa_6f0f5a380d77
name: ACO2
type: Species
is encoded by: hsa:50
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: Q99798
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_34b6ac10_769a_4fa0_966d_988593bedb25
is: Q53HM1
name: UCKL1
constant: false
initial concentration: NaN
is encoded by: hsa:54963
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaR r2083
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110010#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110010#
reversible: true

metaM ksi deg32 l
constant: false
name: keratan sulfate I, degradation product 32
is: CHEBI:12936
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_7f63c6c2_706a_4f6b_9321_74160aa2092b
type: Species
name: DCK
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1633
initial concentration: NaN
is: P27707
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_cb5bd614_02c8_4921_a538_35b15a7e1ee2
name: LDHC
initial concentration: NaN
is encoded by: hsa:3948
constant: false
type: Species
boundary condition: true
has only substance units: false
is: P07864
initial amount: NaN
is: SBO:0000252

metaR AG13T18g
product: MODEL1310110010#
fast: false
is: SBO:0000176
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110010#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110010#
type: Reaction

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM betald c
type: Species
name: betaine aldehyde
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01252
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
constant: false
is: CHEBI:15710
initial amount: NaN
has only substance units: false

metaR RE3627M
name: RE3627
modifier: MODEL1310110010#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
reactant: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
type: Reaction
kinetic law: MODEL1310110010#

metaR RPEc
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
product: MODEL1310110010#
reactant: MODEL1310110010#
name: ribulose 5-phosphate 3-epimerase
is described by: ECO:0000134

metaM dhbpt c
is: CHEBI:20680
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 6,7-dihydrobiopterin
is: SBO:0000247
has only substance units: false
is: HMDB00038
constant: false

metaR RE2987X
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110010#
name: RE2987
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR PI34P5K
reactant: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
modifier: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
is: SBO:0000176
reversible: false
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.68

metaR SERPT
is version of: http://identifiers.org/ec-code/2.3.1.50
is: SBO:0000176
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110010#
name: serine C-palmitoyltransferase

http://identifiers.org/biomodels.db/MODEL1310110010#_f77ae21a_985f_41c7_a505_06e8a707c3c4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1375
boundary condition: true
is: Q92523
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: CPT1B

metaR DOPASFt
name: Dopamine 3-0-sulfate transport (diffusion)
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
is described by: ECO:0000000
product: MODEL1310110010#

metaR LCADi D
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.36
name: lactaldehyde dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110010#_d011c546_532d_4f71_a0b5_e7619f907eaa
is encoded by: hsa:3074
has only substance units: false
initial concentration: NaN
name: HEXB
is: P07686
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_8c33b833_ebd8_48a4_b95d_c4ffd04aeeb7
is: SBO:0000252
is encoded by: hsa:6392
boundary condition: true
constant: false
initial amount: NaN
name: SDHD
is: O14521
has only substance units: false
initial concentration: NaN
type: Species

metaM retinol 9 cis c
constant: false
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: HMDB06217
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17336
is: SBO:0000247
name: 9-cis-retinol

metaR P450SCC1m
fast: false
name: cholesterol monooxygenase
reversible: true
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

http://identifiers.org/biomodels.db/MODEL1310110010#_8cf6daae_57cb_4d97_b730_f65765c4bcee
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:3081
initial amount: NaN
initial concentration: NaN
name: HGD
has only substance units: false
is: Q93099

http://identifiers.org/biomodels.db/MODEL1310110010#_9f407cae_6f27_4fbe_a3e6_129beb0bc776
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:1103
is: Q6LEN6
constant: false
has only substance units: false
initial amount: NaN
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110010#_6dbffb09_03bb_4a86_b01f_2bd4f4321722
name: PYCR1
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5831
type: Species
initial concentration: NaN
is: A6NFM2

metaR r0392
is: SBO:0000176
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction

metaR ALASm
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
kinetic law: MODEL1310110010#
name: 5-aminolevulinate synthase
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.37
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.29
type: Reaction
reversible: false
fast: false

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_4f595820_96a2_4e12_873b_f72f7c9d4f60
name: ENTPD3
boundary condition: true
initial amount: NaN
is encoded by: hsa:956
constant: false
is: O75355
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaM dgmp c
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
initial concentration: 1.0
is: CHEBI:57673
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: dGMP
is: HMDB01044
is: C00362
has only substance units: false
constant: false
type: Species

metaM ins c
type: Species
has only substance units: false
is: C00294
constant: false
is: CHEBI:17596
name: Inosine
is: HMDB00195
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_91adb708_8c1b_46d5_8437_0d3349654ce4
name: PANK2
type: Species
has only substance units: false
is encoded by: hsa:80025
is: SBO:0000252
constant: false
is: Q6P1K9
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_73836574_e1d4_4fec_9011_561791e848db
type: Species
constant: false
is: P08559
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PDHA1
is encoded by: hsa:5160
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_f5aa68c3_752d_4f81_bd91_07a990d7fb98
name: _R51273_1_c
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:R51273
is: SBO:0000252
has only substance units: false

metaM dcacoa x
boundary condition: false
type: Species
has only substance units: false
is: HMDB06404
initial amount: NaN
name: Decanoyl-CoA (n-C10:0CoA)
is: C05274
is: SBO:0000247
is: CHEBI:61430
initial concentration: 1.0
constant: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274

metaR CYSGLYexR
is described by: ECO:0000000
name: L-cysteine/glycine reversible exchanger
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_bc417551_702a_43a5_84e1_78713ee3afda
has only substance units: false
is encoded by: hsa:1503
type: Species
is: P17812
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: CTPS1

http://identifiers.org/biomodels.db/MODEL1310110010#_b3457422_52fd_4a3a_a6da_f3e85f648e1b
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110010#_d5a85282_380a_4f56_a27a_261460cf9640
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: RDH14
is: Q9HBH5
is encoded by: hsa:57665
has only substance units: false

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR r0393
product: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
reversible: false
modifier: MODEL1310110010#
reactant: MODEL1310110010#
fast: false

metaR ARACHCRNt
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#

metaM 5adtststerones c
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
constant: false
is: HMDB06278
initial amount: NaN
type: Species

metaM n2m2masn g
notes: FORMULA: C50H83N4O35X CHARGE: 0
initial amount: NaN
type: Species
boundary condition: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247
has only substance units: false
is: C11530
constant: false
initial concentration: 1.0

metaR r0669
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
is: SBO:0000176
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#

metaM CE4795 x
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,18-21,28-30,34-36,40,51-52H,4-7,10,13,16-17,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,19-18-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4795
type: Species
name: 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:12947
boundary condition: false

metaR r0443
reactant: MODEL1310110010#
product: MODEL1310110010#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction

metaR ACITL
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: ATP-Citrate lyase
modifier: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
fast: false
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.3.8
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_b1d8c26e_6416_45ff_b611_6615a4ebacd3
is: SBO:0000252
name: TH
is encoded by: hsa:7054
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaM ksi pre14 g
initial amount: NaN
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 14
is: CHEBI:28067
is: SBO:0000247
type: Species
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
initial concentration: 1.0
has only substance units: false

metaM btn m
is: HMDB00030
boundary condition: false
is: CHEBI:57586
name: biotinate
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
has only substance units: false
constant: false

metaR RE2998M
reversible: false
name: RE2998
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
product: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#

metaR PCHOLPr hs
type: Reaction
fast: false
modifier: MODEL1310110010#
name: choline phosphatase
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
product: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110010#
reversible: false

metaM retinol 9 cis e
is: SBO:0000247
name: 9-cis-retinol
is: HMDB06217
initial amount: NaN
is: CHEBI:17336
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR RE0944E
name: RE0944
product: MODEL1310110010#
modifier: MODEL1310110010#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
type: Reaction

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR B3GALTg
product: MODEL1310110010#
name: Beta galactosyltransferase
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.86 Confidence Level: 2 AUTHORS: NOTES:general reaction - no gene association get NJ

metaR Ser Thrtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
name: Ser/Thr transport (from golgi to lysosome)

http://identifiers.org/biomodels.db/MODEL1310110010#_7ea7e805_8b63_4898_8279_93d254f1310f
initial amount: NaN
has only substance units: false
is: Q67FW5
is encoded by: hsa:146712
type: Species
constant: false
name: B3GNTL1
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR GALASE7ly
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
is: SBO:0000176
reversible: false
type: Reaction
name: beta-galactosidase, lysosomal

metaM xol7ah2al c
is: CHEBI:27428
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB06894
is: SBO:0000247
boundary condition: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al

metaM 10fthf c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00972

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

metaR r0394
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
kinetic law: MODEL1310110010#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is: SBO:0000176
reversible: true
product: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
type: Reaction

metaM 13 cis retn c
is: http://identifiers.org/pubchem.compound/7847414
name: 13-cis-retinoate
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
initial concentration: 1.0
initial amount: NaN
type: Species
is: D00348
constant: false
is: SBO:0000247
is: HMDB06219
boundary condition: false

metaM xylu L c
has only substance units: false
is: CHEBI:17399
type: Species
name: L-xylulose
is: HMDB00751
constant: false
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR FE3MTP1
modifier: MODEL1310110010#
is described by: ECO:0000134
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
name: transport of ferrous iron into blood
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reversible: false

metaM dolp U c
boundary condition: false
type: Species
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57683
name: dolichyl phosphate(2-)
constant: false
is: SBO:0000247

metaR r0668
product: MODEL1310110010#
type: Reaction
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
modifier: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.2.19

metaM dgmp e
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57673
initial concentration: 1.0
is: HMDB01044
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
type: Species
name: dGMP(2-)

metaM HC01434 x
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
name: oxalatosuccinate(3-)
is: SBO:0000247
has only substance units: false
is: CHEBI:58931

metaR SERGLNexR
product: MODEL1310110010#
name: L-Serine/Glutamine reversible exchange
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
is: SBO:0000185
type: Reaction
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_7a4c9a91_1ed7_47b8_a406_76143c535027
initial concentration: NaN
initial amount: NaN
constant: false
name: NDUFA5
is: Q16718
has only substance units: false
boundary condition: true
is encoded by: hsa:4698
type: Species
is: SBO:0000252

metaR ADRNCOAtx
name: fatty acid intracellular transport
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_b7375bd0_b6a2_44c2_a39d_af879caaddab
constant: false
initial amount: NaN
is encoded by: hsa:4512
has only substance units: false
name: COX1
is: Q7GXY8
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaR r1487
product: MODEL1310110010#
type: Reaction
name: EC:6.2.1.3
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM cholcoa x
is: HMDB01374
is: SBO:0000247
boundary condition: false
is: CHEBI:57373
constant: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: choloyl-CoA(4-)
type: Species

metaR RAI2
reactant: MODEL1310110010#
name: retinal isomerase (9-cis)
reversible: true
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaM btn n
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: HMDB00030
has only substance units: false
initial concentration: 1.0
name: biotinate
is: CHEBI:57586
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false

metaR ST8SIA12
is: SBO:0000176
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
name: Beta-galactoside alpha-2,3-sialyltransferase
fast: false
modifier: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.8
reversible: false
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_1c530f8b_8c1f_4770_a031_ffd343d06e07
is: O00400
type: Species
is encoded by: hsa:9197
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: SLC33A1
constant: false
has only substance units: false

metaR DHFtm
reversible: true
name: dihydrofolate reversible mitochondrial transport
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR RE3000M
is: SBO:0000176
product: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3000
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_34b71f0f_80e9_48b1_a6cf_55af616ce832
constant: false
name: MGAT1
boundary condition: true
initial amount: NaN
is encoded by: hsa:4245
initial concentration: NaN
type: Species
is: P26572
is: SBO:0000252
has only substance units: false

metaM thcholstoic m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
boundary condition: false
is: CHEBI:18402
is: HMDB03873
is: SBO:0000247
type: Species
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

metaM n2m2nmn l
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
is: SBO:0000247
is: HMDB00939
is: CHEBI:16680
has only substance units: false
type: Species
constant: false
notes: FORMULA: C50H84N4O36 CHARGE: 0

metaM nadph m
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
initial amount: NaN
is: CHEBI:57783
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
constant: false
type: Species
is: HMDB00221
initial concentration: 1.0

metaR ASPTA
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
name: aspartate transaminase
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
kinetic law: MODEL1310110010#

metaR SQLEr
is version of: http://identifiers.org/ec-code/1.14.13.132
fast: false
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
name: Squalene epoxidase, endoplasmic reticular (NADP)
modifier: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#
is described by: ECO:0000134
reactant: MODEL1310110010#
reversible: false
type: Reaction
kinetic law: MODEL1310110010#

metaR KSItly
reversible: false
reactant: MODEL1310110010#
name: keratan sulfate I transport, extracellular to lysosome
type: Reaction
is: SBO:0000185
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR RE1516M
is: SBO:0000176
name: RE1516
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
modifier: MODEL1310110010#
fast: false
type: Reaction
product: MODEL1310110010#

metaR PNTOte
type: Reaction
name: Transport of (R)-Pantothenate
is: SBO:0000185
reactant: MODEL1310110010#
reversible: true
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110010#_78cd03ec_5e2b_4f5d_a643_c9fe40bdb6bb
boundary condition: true
initial concentration: NaN
name: ALDH3A2
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:224
is: P51648
type: Species

metaM 25hvitd3 m
initial amount: NaN
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 EHMN_ABBREVIATION: C01561
initial concentration: 1.0
is: HMDB03550
name: calcidiol
type: Species
is: SBO:0000247
constant: false
is: CHEBI:17933
boundary condition: false
has only substance units: false

metaM core4 g
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:16478
notes: FORMULA: C24H40N3O15X CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false
name: Core 4
type: Species

metaM fucacgalfucgalacglcgalgluside hs c
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
constant: false
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
is: C00445
has only substance units: false
is: CHEBI:57455
is: HMDB01354
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r0181
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
reactant: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#

metaM arachdcrn m
name: C20:4 carnitine
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:57387
is: HMDB01322
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
constant: false
boundary condition: false
is: SBO:0000247

metaR RE1845X
is: SBO:0000176
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE1845
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
product: MODEL1310110010#
fast: false
reversible: true
reactant: MODEL1310110010#

metaM C05280 m
is: HMDB03952
type: Species
name: cis,cis-3,6-Dodecadienoyl-CoA
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:28002
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280

metaR DPMVDx
reversible: false
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is described by: ECO:0000134
name: diphosphomevalonate decarboxylase
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.33
modifier: MODEL1310110010#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_0621c543_2428_4a1d_8d6e_5babbeaceebc
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:5336
initial amount: NaN
name: PLCG2
is: SBO:0000252
type: Species
boundary condition: true
is: P16885

metaR NRPPHRSULT
type: Reaction
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.8.2.1
is described by: ECO:0000269
reversible: false
is: SBO:0000176
modifier: MODEL1310110010#
product: MODEL1310110010#
name: Norepinephrine Sulfotransferase
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)

metaM xol7ah2al m
type: Species
is: CHEBI:27428
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB06894
initial concentration: 1.0
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445

metaR THYOXt2
is described by: ECO:0000269
name: T4 transport via facilitated diffusion
modifier: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
fast: false
type: Reaction
product: MODEL1310110010#

metaR CHOLESTle
is version of: http://identifiers.org/ec-code/3.1.1.13
reactant: MODEL1310110010#
name: hydrolysis of cholesterol ester by cholesterol esterase
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaM sphgn c
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: HMDB00269
initial concentration: 1.0
is: CHEBI:57817
name: sphinganine(1+)
boundary condition: false

metaM n4m2masn g
name: ((N-acetyl-D-glucosaminyl)4-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: C05881
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C66H109N6O45X CHARGE: 0
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_855fc9b2_de1d_400f_901c_b1e7a620a2bb
constant: false
has only substance units: false
is encoded by: hsa:2224
initial concentration: NaN
type: Species
initial amount: NaN
name: FDPS
is: P14324
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_6f77e568_1e37_4ff0_8508_1d2a27787229
is: P04746
has only substance units: false
is encoded by: hsa:279
name: AMY2A
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_8d400b11_763c_4123_a2a5_778a2b23eff6
name: _AI440329_1_r
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:AI440329
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM dudp m
is: HMDB01000
initial amount: NaN
name: dUDP(3-)
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false
is: CHEBI:60471
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR G14T19g
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
reversible: false

metaM tetpent3 e
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB06323
constant: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
name: tetracosapentaenoic acid, n-3
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_7a9680ff_d316_469c_812f_09dd1dc5aa7c
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: A8K3J4
initial amount: NaN
name: CA14
is encoded by: hsa:23632
boundary condition: true

metaR INSTt2r
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
is: SBO:0000185
name: inositol transport in via proton symport
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
product: MODEL1310110010#
type: Reaction

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_84bf2e3e_590d_4795_8b9e_09eab4808365
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: GGT1
is encoded by: hsa:2678
is: SBO:0000252
type: Species

metaM C05279 m
is: HMDB11123
is: CHEBI:28387
type: Species
has only substance units: false
boundary condition: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279

metaM mercplaccys e
is: HMDB06512
type: Species
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
name: 3-mercaptolactate-cysteine disulfide
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_89571179_7086_4174_873b_546d3d115901
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1807
constant: false
boundary condition: true
type: Species
name: DPYS
initial concentration: NaN
initial amount: NaN
is: Q14117

metaR r0512
type: Reaction
reactant: MODEL1310110010#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is: SBO:0000176
kinetic law: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
fast: false
modifier: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000

metaR FUMSO4tm
reactant: MODEL1310110010#
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110010#
is described by: ECO:0000269
reversible: true
product: MODEL1310110010#
name: Fumarate:sulfate antiport, mitochondrial
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaM acac m
type: Species
is: CHEBI:13705
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
name: acetoacetate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_d4687b29_ecff_46c2_bf11_18bf9bc7157d
name: CPT2
has only substance units: false
is encoded by: hsa:1376
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: P23786
is: SBO:0000252
initial concentration: NaN

metaR r0450
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
reversible: true
fast: false
product: MODEL1310110010#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:

metaR G14T11g
reversible: false
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR LEUPHELAT2tc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_a991364e_2f15_46db_b9dc_e159e3ce69ea
initial concentration: NaN
is: Q9H999
is: SBO:0000252
name: PANK3
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:79646
has only substance units: false

metaM 56dura c
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
has only substance units: false
name: 5,6-dihydrouracil
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00076
boundary condition: false
is: CHEBI:15901

http://identifiers.org/biomodels.db/MODEL1310110010#_ee43e6a8_c392_475c_a390_2b33e0c44cb7
is: P20020
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: ATP2B1
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:490

metaR PYNP2r
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.3
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
modifier: MODEL1310110010#
name: pyrimidine-nucleoside phosphorylase (uracil)
reactant: MODEL1310110010#
product: MODEL1310110010#

metaR FAOXC226205m
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110010#
product: MODEL1310110010#
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110010#

metaM m6mpdol U r
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20
initial amount: NaN
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
is: CHEBI:37635
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_0e1469af_d797_4a83_8c32_d02fda74e61e
constant: false
type: Species
is: O00476
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SLC17A3
is encoded by: hsa:10786
has only substance units: false

metaR r0809
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
name: Facilitated diffusion
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
modifier: MODEL1310110010#

metaM fucacgalfucgalacglcgalgluside hs e
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00121
initial amount: NaN
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
type: Species
constant: false
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0

metaR 4HOXPACDOX NADP
reactant: MODEL1310110010#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reversible: true
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110010#

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR INOSTO
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (55586.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 1.13.99.1 Confidence Level: 4 AUTHORS: PMID:15504367 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.13.99.1
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
name: inositol oxygenase
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_5698c02c_6564_4a65_a10f_f1c4b4c500ae
boundary condition: true
is encoded by: hsa:53905
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q9NRD9
constant: false
name: DUOX1

http://identifiers.org/biomodels.db/MODEL1310110010#_fa93c61f_c8b6_4a3e_9f20_882c429c1987
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q99714
type: Species
is: SBO:0000252
name: HSD17B10
initial amount: NaN
is encoded by: hsa:3028
constant: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_d312f8a5_2cbf_4219_ae69_0ced25495ccb
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:6785
type: Species
name: ELOVL4
constant: false
initial concentration: NaN
is: Q9GZR5
has only substance units: false

metaR r0451
kinetic law: MODEL1310110010#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2
is described by: ECO:0000000
reactant: MODEL1310110010#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
is: SBO:0000176
reversible: false
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_a2c1b5e8_ea78_40fe_b717_ebb15111b8bd
initial concentration: NaN
is: SBO:0000252
is: P38571
type: Species
initial amount: NaN
is encoded by: hsa:3988
has only substance units: false
name: LIPA
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_106f983b_8dc0_4d6d_b2c4_f8d1fa24d6f1
constant: false
has only substance units: false
initial concentration: NaN
is: P31040
boundary condition: true
is: SBO:0000252
type: Species
name: SDHA
is encoded by: hsa:6389
initial amount: NaN

metaM cbasp e
has only substance units: false
initial amount: NaN
name: N-Carbamoyl-L-aspartate
is: CHEBI:32814
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00438
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: HMDB00828

metaM aacoa c
has only substance units: false
is: C00332
initial concentration: 1.0
is: HMDB01484
initial amount: NaN
constant: false
name: Acetoacetyl-CoA
is: SBO:0000247
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
type: Species
is: CHEBI:57286

http://identifiers.org/biomodels.db/MODEL1310110010#_1d121d70_dfa5_40d0_acd9_279b76e9be5c
has only substance units: false
initial amount: NaN
is: Q969I6
is: SBO:0000252
constant: false
is encoded by: hsa:55089
initial concentration: NaN
boundary condition: true
type: Species
name: SLC38A4

metaR ALCD2yf
reversible: false
type: Reaction
is described by: ECO:0000134
fast: false
modifier: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD

metaR UGT1A10r
reactant: MODEL1310110010#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
kinetic law: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.4.1.17
modifier: MODEL1310110010#
product: MODEL1310110010#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal

metaM tetpent3 c
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB06323
name: tetracosapentaenoic acid, n-3
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
constant: false
initial concentration: 1.0

metaM hexc c
is: HMDB02356
is: SBO:0000247
name: cerotate
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
is: CHEBI:31013
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_401c8dce_fe66_466e_a902_b1d0e3a2ee2b
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is: F5GWR4
is encoded by: hsa:9481
name: SLC25A27

metaM retn r
initial amount: NaN
boundary condition: false
is: CHEBI:35291
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: all-trans-retinoate
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777

http://identifiers.org/biomodels.db/MODEL1310110010#_b47fb00f_c519_49e2_a675_58d932ca4945
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:7001
is: SBO:0000252
type: Species
name: PRDX2
is: P32119
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_286fac00_3b15_4301_a698_5520b6b8511b
initial amount: NaN
boundary condition: true
name: GALNT14
is: Q96FL9
is encoded by: hsa:79623
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r0514
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
product: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
is described by: ECO:0000000

metaR R group phosphotase 3
reactant: MODEL1310110010#
name: R group phosphotase 3
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110010#

metaM mercplaccys c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
is: HMDB06512
boundary condition: false
has only substance units: false
name: 3-mercaptolactate-cysteine disulfide
type: Species
is: SBO:0000247
constant: false

metaR r2112
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110010#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
is described by: ECO:0000000
fast: false

metaM glu L m
is: HMDB00148
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29985
boundary condition: false
has only substance units: false
name: L-glutamate(1-)
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false

metaR NACHEXA16ly
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
type: Reaction
modifier: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
kinetic law: MODEL1310110010#
fast: false

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR FALDH
name: formaldehyde dehydrogenase
product: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110010#
fast: false
reversible: true
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110010#_19bbeca5_20bf_4449_a079_1dbb06a485d9
is: Q9Y2C3
name: B3GALT5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10317
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_19cb74e8_6d23_4efc_bafe_dadf7554a309
name: B3GALNT1
is encoded by: hsa:8706
type: Species
boundary condition: true
is: O75752
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR 25HVITD3t
kinetic law: MODEL1310110010#
type: Reaction
fast: false
reversible: false
is: SBO:0000185
name: 25-hydroxyvitamin D3 transport from cytoplasm
is described by: ECO:0000000
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12045394 NOTES:is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT. Biochemical

metaR AG13T1g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110010#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110010#
type: Reaction
reversible: false

metaM m8mpdol U r
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:59093
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR SERDGLNexR
name: D-Serine/Glutamine reversible exchange
modifier: MODEL1310110010#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_0a5227f7_4ed2_4570_8db8_5b726357c1f3
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:57468
boundary condition: true
is: SBO:0000252
name: SLC12A5
is: Q9H2X9
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_376ea0ae_f616_492f_b20c_3552599a4bca
constant: false
name: SUOX
boundary condition: true
has only substance units: false
is encoded by: hsa:6821
is: P51687
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_3ee71405_cd1a_49c3_813e_e96f086c8ab1
is encoded by: hsa:7378
has only substance units: false
name: UPP1
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

metaM g1m8masn r
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
is: C05875
type: Species
has only substance units: false
constant: false
notes: FORMULA: C76H127N2O60X CHARGE: 0
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR ACNACNGALGBSIDEte
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
reactant: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
name: acnacngalgbside hs transport
product: MODEL1310110010#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_aea79b6a_904b_4243_ba79_c4ff4141ab92
initial amount: NaN
is encoded by: hsa:2954
name: GSTZ1
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: A6NED0
type: Species

metaR r2111
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is: SBO:0000185

metaR r0186
fast: false
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
reversible: false
is: SBO:0000176
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM cl e
name: Chloride
initial concentration: 1.0
is: CHEBI:3966
is: SBO:0000247
has only substance units: false
type: Species
is: C00115
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00492
notes: FORMULA: Cl CHARGE: -1

metaR EX cholate LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholate
type: Reaction

metaM T antigen g
notes: FORMULA: C14H24NO10X CHARGE: 0
name: T antigen (core 1)
initial concentration: 1.0
type: Species
is: CHEBI:22783
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_4c762009_deb4_4249_aa64_daa856f48f66
is encoded by: hsa:2584
has only substance units: false
initial amount: NaN
name: GALK1
constant: false
initial concentration: NaN
is: SBO:0000252
is: P51570
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_9f1def20_e761_4127_a034_fe257a137bd3
constant: false
type: Species
name: SLC4A5
is: SBO:0000252
is encoded by: hsa:57835
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM m6masnC g
is: SBO:0000247
notes: FORMULA: C58H97N2O45X CHARGE: 0
initial amount: NaN
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01356
has only substance units: false
is: CHEBI:57312

metaM btn c
is: CHEBI:3420
has only substance units: false
initial amount: NaN
type: Species
is: C00120
boundary condition: false
constant: false
is: HMDB00030
name: Biotin
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial concentration: 1.0

metaR r0899
reactant: MODEL1310110010#
type: Reaction
name: Amino acid transporter ATB0+ Facilitated diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_aedf5afc_d0cc_4cf8_bbe2_a1506c40e337
is encoded by: hsa:10400
initial concentration: NaN
boundary condition: true
name: PEMT
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_f34c17db_a430_43a6_8447_8ba0162ee0ee
is: Q15392
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:1718
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: DHCR24
boundary condition: true

metaM hexc e
name: cerotate
boundary condition: false
is: SBO:0000247
is: CHEBI:31013
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB02356
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
type: Species

metaR PVD3
kinetic law: MODEL1310110010#
name: Previtamin D3 formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
is: SBO:0000176
reactant: MODEL1310110010#
reversible: true
type: Reaction
is described by: ECO:0000134
fast: false
product: MODEL1310110010#

metaR DM n5m2masn g
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM n5m2masn(g)
type: Reaction

metaR R group phosphotase 1
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
type: Reaction
name: R group phosphotase 1
is: SBO:0000176
kinetic law: MODEL1310110010#
reversible: false

metaR r0926
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
name: Postulated transport reaction
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
product: MODEL1310110010#

metaR r2110
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reversible: true
is: SBO:0000185
fast: false
type: Reaction

metaR UDPGLCAter
is described by: ECO:0000269
fast: false
modifier: MODEL1310110010#
reactant: MODEL1310110010#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
product: MODEL1310110010#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110010#_f6f65fbb_39e1_4e55_b13b_1ef24e6af436
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI435857
type: Species
name: _AI435857_1_x
initial concentration: NaN
boundary condition: true

metaR EX 34hpp
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_33792ff3_78a8_4818_a888_97d0986ccee3
name: GOT1
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:2805
type: Species
initial concentration: NaN
is: SBO:0000252
is: P17174

metaM dcacoa m
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
name: Decanoyl-CoA (n-C10:0CoA)
is: C05274
is: HMDB06404
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:61430
constant: false
is: SBO:0000247

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_6321a083_e491_4d89_a38c_815a39c5d253
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:1346
is: P24310
name: COX7A1
boundary condition: true

metaR GALtly
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
type: Reaction
reversible: false
name: galactose efflux from lysosome
reactant: MODEL1310110010#
is: SBO:0000185

metaR CYSGLTH
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
type: Reaction
name: Glutathione:cystine oxidoreductase
is: SBO:0000176
product: MODEL1310110010#
reversible: true

metaM dmpp x
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
has only substance units: false
type: Species
is: CHEBI:57623
is: HMDB01120
name: prenyl diphosphate(3-)
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_5a8f6d0b_4d9e_4185_95ec_76ed64aa7cf5
has only substance units: false
constant: false
is: P49748
type: Species
is: SBO:0000252
is encoded by: hsa:37
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ACADVL

metaR R group phosphotase 2
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
name: R group phosphotase 2
reversible: false
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#

metaR ACNACNGALGBSIDEtg
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reactant: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
reversible: true
name: acnacngalgbside hs intracellular transport
product: MODEL1310110010#

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
modifier: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
name: beta-galactosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110010#_65f5f78a_bec3_4a83_82d3_21591fc42304
name: B3GNT3
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10331
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: Q9Y2A9

http://identifiers.org/biomodels.db/MODEL1310110010#_319de2e2_af3f_457c_95ab_b5bb1810476c
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM ksii core2 pre1 g
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:28067
notes: FORMULA: C33H53N3O23X CHARGE: -1
constant: false
initial concentration: 1.0
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_d1b29308_64c1_49a9_aee7_5e78543c1d18
name: GGCT
constant: false
is encoded by: hsa:79017
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: B8ZZR8
boundary condition: true

metaM ksi pre6 g
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 6
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C107H174N7O80SX CHARGE: -2
is: CHEBI:58053
initial concentration: 1.0
is: C00130
is: HMDB00175

metaM phytcoa x
has only substance units: false
name: phytanoyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57391
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: HMDB01359

metaR TYRt
is: SBO:0000185
fast: false
type: Reaction
name: L-tyrosine transport
product: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110010#

metaR 34DHPHELAT1tc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3,4-Dihydroxy-L-phenylalanine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaM CE0713 m
initial concentration: 1.0
is: SBO:0000247
is: HMDB02329
type: Species
name: 3-oxolinoleoyl-CoA
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
constant: false
has only substance units: false
is: CHEBI:30623

metaM tettet6coa x
initial amount: NaN
initial concentration: 1.0
is: C16171
constant: false
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
has only substance units: false
boundary condition: false
name: tetracosatetraenoyl coenzyme A
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205481
type: Species
is: HMDB06516

metaM cl c
initial concentration: 1.0
has only substance units: false
is: CHEBI:3966
type: Species
is: SBO:0000247
boundary condition: false
is: C00115
initial amount: NaN
constant: false
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
name: Chloride

metaM itaccoa m
type: Species
initial amount: NaN
name: itaconyl-CoA(5-)
is: SBO:0000247
boundary condition: false
is: HMDB03377
has only substance units: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
initial concentration: 1.0
constant: false
is: CHEBI:57381

metaM btn e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:3420
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false
is: C00120
constant: false
initial amount: NaN
is: HMDB00030
name: Biotin
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_7547a469_4a45_4882_9c9e_b9f3c9b244bf
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:AI990637
type: Species
boundary condition: true
name: _AI990637_1_x
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_604ddb60_bc94_482d_a4ce_b64aff3f76ab
constant: false
name: NMNAT2
is: SBO:0000252
is encoded by: hsa:23057
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaR IPDDIx
name: isopentenyl-diphosphate D-isomerase
fast: false
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000134
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/5.3.3.2

http://identifiers.org/biomodels.db/MODEL1310110010#_7e8f5941_b71d_48f3_957d_a36f4d1a5c1c
type: Species
boundary condition: true
is encoded by: hsa:212
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ALAS2
is: Q5JZF5
initial concentration: NaN

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR CERT2rt
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: ceramide transport protein
type: Reaction
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110010#

metaR XOLDIOLONEt
kinetic law: MODEL1310110010#
type: Reaction
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
is: SBO:0000185
reactant: MODEL1310110010#
reversible: true
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_74d0c422_c59a_4a78_b545_123978849028
is: SBO:0000252
is: Q9H5J4
is encoded by: hsa:79071
type: Species
initial concentration: NaN
initial amount: NaN
name: ELOVL6
has only substance units: false
boundary condition: true
constant: false

metaM 3hmp m
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:11805
name: 3-hydroxy-2-methylpropanoate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
initial amount: NaN
type: Species
is: HMDB00023
is: SBO:0000247
initial concentration: 1.0

metaM frdp x
is: CHEBI:175763
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00961
name: farnesyl pyrophosphate(3-)

metaM cyan m
is: SBO:0000247
name: hydrogen cyanide
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
boundary condition: false
is: CHEBI:18407
initial amount: NaN
is: HMDB02084
initial concentration: 1.0
type: Species
has only substance units: false

metaM CE2705 n
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
name: quinonoid dihydrobiopterin
constant: false
is: HMDB02281
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15374
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

metaR r2103
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaM 3mox4hpac m
constant: false
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: CHEBI:28111
is: HMDB05175

metaM HC01434 m
is: CHEBI:58931
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
boundary condition: false
name: oxalatosuccinate(3-)

metaR FAOXC180x
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: NOTES:- in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
name: Beta oxidation of long chain fatty acid
reversible: false
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000269
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r2194
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_3505da26_4311_43d9_a805_abad755f6f60
is: SBO:0000252
type: Species
initial concentration: NaN
is: P55851
boundary condition: true
name: UCP2
has only substance units: false
initial amount: NaN
is encoded by: hsa:7351
constant: false

metaR r0178
is version of: http://identifiers.org/ec-code/2.5.1.21
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
type: Reaction
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
reversible: true
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_d9871edb_7d36_4f7a_ac50_6e9659f51a03
constant: false
is: Q9NRD8
is: SBO:0000252
boundary condition: true
name: DUOX2
is encoded by: hsa:50506
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM nad m
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57540
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
is: HMDB00902
is: C00003
has only substance units: false
name: Nicotinamide adenine dinucleotide

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_67db9f7e_e24d_4771_94b5_6d36f2831607
initial concentration: NaN
boundary condition: true
is: Q9NY65
name: EHHADH
is encoded by: hsa:1962
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM ksi pre32 g
type: Species
name: keratan sulfate I biosynthesis, precursor 32
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:28067
has only substance units: false
initial amount: NaN

metaM nadp m
constant: false
name: Nicotinamide adenine dinucleotide phosphate
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial amount: NaN
initial concentration: 1.0
is: HMDB00217
type: Species
is: C00006

metaM retn e
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
name: all-trans-retinoate
is: CHEBI:35291
has only substance units: false
constant: false
is: HMDB01852
initial amount: NaN

metaM lys L e
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
is: CHEBI:32551
has only substance units: false
name: L-lysinium(1+)
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00182
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_76927bfe_c9f4_4d0f_ba65_fc5f2f2c074a
has only substance units: false
type: Species
name: TPI1P2
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:286016

metaR r2104
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110010#
fast: false
type: Reaction

metaM g6p r
constant: false
initial concentration: 1.0
is: CHEBI:61548
is: HMDB01401
type: Species
is: C00092
is: SBO:0000247
has only substance units: false
name: D-Glucose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
boundary condition: false
initial amount: NaN

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_b38b51b0_9cf4_4aa9_b715_4d8a42a37bfc
type: Species
is encoded by: hsa:4830
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: NME1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_6011cea9_f19d_40be_b6b6_bb9c3ee1d000
constant: false
is encoded by: hsa:51
name: ACOX1
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q15067
initial concentration: NaN

metaR r1556
reversible: true
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_698c6b74_d8d6_40e9_8a0d_fdcd32262c79
initial amount: NaN
name: DGKH
boundary condition: true
initial concentration: NaN
constant: false
is: A8K0I1
is: SBO:0000252
is encoded by: hsa:160851
type: Species
has only substance units: false

metaR r0936
reactant: MODEL1310110010#
reversible: false
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM c226crn m
constant: false
initial amount: NaN
initial concentration: 1.0
name: cervonyl carnitine
is: SBO:0000247
type: Species
is: HMDB06510
is: http://identifiers.org/pubchem.compound/127055
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false
has only substance units: false

metaM fum c
type: Species
name: Fumarate
is: CHEBI:29806
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false
initial concentration: 1.0
is: C00122
initial amount: NaN
is: HMDB00134

http://identifiers.org/biomodels.db/MODEL1310110010#_97bde7fb_6971_43cf_831b_c9a2675fe1a8
type: Species
name: CYP8B1
is encoded by: hsa:1582
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9UNU6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ac1eda0c_4ab9_418b_9e4e_cebf6f9271bd
boundary condition: true
is: O60762
is encoded by: hsa:8813
is: SBO:0000252
name: DPM1
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaM nadh m
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01487
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
constant: false
is: CHEBI:57945
boundary condition: false

metaR r2193
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110010#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true

metaM fn2m2masn g
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
initial amount: NaN
is: CHEBI:32984
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_18a1ec9e_c525_4467_aac1_40959925dcc0
name: NDUFB3
initial concentration: NaN
constant: false
is encoded by: hsa:4709
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q6IB80
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_67887954_ba65_4059_8e57_85bb97e52735
is encoded by: hsa:9990
type: Species
name: SLC12A6
initial concentration: NaN
initial amount: NaN
is: Q9UHW9
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaM 5oxpro c
type: Species
constant: false
name: 5-oxoprolinate
is: CHEBI:57606
initial amount: NaN
is: SBO:0000247
is: HMDB00267
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
initial concentration: 1.0
has only substance units: false

metaR RE0691C
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reversible: true
name: RE0691
is: SBO:0000176
fast: false
reactant: MODEL1310110010#

metaM n3m2masn g
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: ((N-acetyl-D-glucosaminyl)3-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0
is: C05881
boundary condition: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
is: SBO:0000247

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR ACACT7p
reactant: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
kinetic law: MODEL1310110010#
is described by: ECO:0000269

metaM 3hmbcoa m
is: HMDB01356
is: CHEBI:57312
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaR ILETA
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
name: isoleucine transaminase

http://identifiers.org/biomodels.db/MODEL1310110010#_d5b56e71_f37b_412e_b64c_0d8e351a7501
initial amount: NaN
is: SBO:0000252
is: O14975
initial concentration: NaN
is encoded by: hsa:11001
constant: false
name: SLC27A2
has only substance units: false
boundary condition: true
type: Species

metaR r2101
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110010#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110010#_77394f99_1fe4_4bee_9c86_8cb5f7778bc3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4907
type: Species
is: P21589
is: SBO:0000252
name: NT5E
initial amount: NaN
constant: false
has only substance units: false

metaR r0813
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
reactant: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
fast: false
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
is described by: ECO:0000000

metaR r1553
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2196
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110010#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_1d00621a_33b5_4957_a7eb_02a27a4dd0cd
is: P39656
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:1650
name: DDOST
initial concentration: NaN

metaR FAOXC180
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
fast: false
name: Beta oxidation of long chain fatty acid
product: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110010#

metaM citr L e
is: HMDB00904
name: citr_L[e]
has only substance units: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16349
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_f42a3992_b147_4553_8249_f3ce52d07844
type: Species
name: _AU149534_1_m
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AU149534

metaM srtn c
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: HMDB00259
initial concentration: 1.0
constant: false
name: serotonin(1+)
type: Species
boundary condition: false
is: CHEBI:350546
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM retn c
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: all-trans-retinoate
has only substance units: false
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
is: HMDB01852
initial amount: NaN

metaM ac m
is: HMDB00042
is: CHEBI:30089
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: acetate
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_e5f55656_1e66_410e_ba77_8ce1634a9ccb
is: E7EPT3
initial concentration: NaN
is encoded by: hsa:501
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
name: ALDH7A1
initial amount: NaN

metaR r2102
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110010#

metaR MG1er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.106
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110010#
type: Reaction
reversible: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_9dc141c9_093f_4dcf_b19c_88dbb0902a24
is: SBO:0000252
constant: false
initial amount: NaN
is: P30838
has only substance units: false
boundary condition: true
name: ALDH3A1
is encoded by: hsa:218
type: Species
initial concentration: NaN

metaR r0179
product: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
reactant: MODEL1310110010#

metaR RE1804M
reactant: MODEL1310110010#
is described by: ECO:0000000
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
name: RE1804
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaR PSP L
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
reversible: false
is described by: ECO:0000269
name: phosphoserine phosphatase (L-serine)
type: Reaction
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.3
product: MODEL1310110010#

metaR r1554
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000000

metaR r2195
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110010#
reversible: true
is: SBO:0000185
product: MODEL1310110010#
fast: false

metaR S6T18g
modifier: MODEL1310110010#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.21
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.8.2.17
fast: false
is: SBO:0000176
type: Reaction

metaM fad m
is: C00016
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
is: HMDB01248
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_51f4cdfc_550e_4631_a488_8b5fbc87bce8
initial amount: NaN
is encoded by: hsa:1798
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: DPAGT1

metaR GALASE16ly
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
type: Reaction

metaR r0812
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41

http://identifiers.org/biomodels.db/MODEL1310110010#_9065a253_47e6_4dce_9dfe_91c6245afe20
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:2530
initial concentration: NaN
name: FUT8
constant: false
is: SBO:0000252
is: A8K8P8

metaR r2107
modifier: MODEL1310110010#
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false

metaR SBT Dtde
reactant: MODEL1310110010#
fast: false
type: Reaction
product: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110010#
name: D-sorbitol transport, extracellular

metaM cbasp c
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
name: N-Carbamoyl-L-aspartate
initial concentration: 1.0
is: CHEBI:32814
boundary condition: false
is: HMDB00828
has only substance units: false
is: C00438
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

metaR r2327
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

metaM nadph r
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
boundary condition: false
is: CHEBI:57783
is: C00005
initial concentration: 1.0
is: SBO:0000247
is: HMDB00221
constant: false
has only substance units: false
type: Species

metaM HC00900 c
constant: false
name: Methylmalonate
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:30860
initial concentration: 1.0
is: SBO:0000247

metaR AACOAT
kinetic law: MODEL1310110010#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
type: Reaction
modifier: MODEL1310110010#
reversible: true
product: MODEL1310110010#
is: SBO:0000176
name: Acetoacetyl-CoA:acetate CoA-transferase
reactant: MODEL1310110010#

metaR r1751
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110010#

metaR SACCD3m
is described by: ECO:0000269
is: SBO:0000176
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
kinetic law: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.8
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM

metaR FAOXC18480x
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110010#_cdec729e_813e_417b_86a9_9a3c7eb4adaf
boundary condition: true
name: DPM2
has only substance units: false
is: O94777
constant: false
initial concentration: NaN
is encoded by: hsa:8818
is: SBO:0000252
type: Species
initial amount: NaN

metaM citr L c
has only substance units: false
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN
is: HMDB00904
type: Species
name: L-citrulline
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:16349

metaM gdp n
boundary condition: false
name: GDP(3-)
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:58189
constant: false
is: HMDB01201
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaR ITPtn
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#
reversible: true
name: ITP nuclear transport
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110010#
is: SBO:0000185

metaR r2198
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_4850cc2b_8ea3_49a3_a03f_3afdc33223aa
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: ALPP
is encoded by: hsa:250
is: P05187
has only substance units: false

metaR S6T11g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR r1559
reversible: true
product: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaM Lcystin c
name: L-cystine
is: HMDB00192
is: CHEBI:16283
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_d5c03cff_a952_430b_b337_8d8bd05cbcc0
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9P109
has only substance units: false
constant: false
is encoded by: hsa:51301
name: GCNT4
initial concentration: NaN
type: Species

metaM HC00250 e
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
boundary condition: false
initial amount: NaN
type: Species
name: hydrosulfide
initial concentration: 1.0
is: CHEBI:29919

metaR r2108
kinetic law: MODEL1310110010#
reversible: true
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110010#
type: Reaction
is: SBO:0000185

metaM srtn e
constant: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
name: serotonin(1+)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:350546
boundary condition: false
is: SBO:0000247
is: HMDB00259
has only substance units: false

metaR r2328
is described by: ECO:0000000
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
product: MODEL1310110010#
type: Reaction
reversible: true
reactant: MODEL1310110010#

metaR NACHEXA10ly
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110010#
name: beta-N-acetylhexosaminidase A, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110010#_b6062275_77e5_48cb_aee4_94f98775bdb2
initial concentration: NaN
is: O43175
constant: false
name: PHGDH
is encoded by: hsa:26227
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_f05cf795_c52c_4df0_9ea5_b6a9cee7b814
boundary condition: true
name: HSD17B4
has only substance units: false
initial amount: NaN
is encoded by: hsa:3295
type: Species
is: SBO:0000252
is: E9PB82
initial concentration: NaN
constant: false

metaR r1752
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport

metaR VALt5m
name: Valine reversible mitochondrial transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
product: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_196c58ad_f9fb_4a45_87c7_73b002b02f83
name: _AA664770_1_m
boundary condition: true
has only substance units: false
is encoded by: hsa:AA664770
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

metaR r2197
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
is: SBO:0000185
reversible: true
modifier: MODEL1310110010#
product: MODEL1310110010#
fast: false

metaR DNDPt15m
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
reversible: false
name: dUDP transport via dGDP antiport
is: SBO:0000185
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110010#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110010#_2e3df28e_a2f5_47bf_b954_d5f3305ffcd7
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: PANK1
is encoded by: hsa:53354
initial amount: NaN
initial concentration: NaN
type: Species

metaR A MANASEly
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.24
reversible: false
reactant: MODEL1310110010#
fast: false
name: alpha-mannosidase, lysosomal
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR r2105
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110010#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR NDP7er
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
is: SBO:0000176
product: MODEL1310110010#
reactant: MODEL1310110010#

metaR NADPtxu
name: NADP transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
is described by: ECO:0000000
reversible: false
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
fast: false
type: Reaction

metaR RETFA
name: retinol acyltransferase
fast: false
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110010#

metaR r2329
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000185

metaR C4STMO1r
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
product: MODEL1310110010#
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
reactant: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.72
is: SBO:0000176
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_5118078e_bde8_492f_9484_f9bfde669f3f
constant: false
is: O60331
type: Species
is encoded by: hsa:23396
initial concentration: NaN
name: PIP5K1C
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_9e551187_247e_409a_b0af_0c997dfcf640
initial amount: NaN
is: O95470
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:8879
initial concentration: NaN
name: SGPL1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_14112ed3_38e1_4ed6_9a22_108a781b0385
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: _AI539321_1_c
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI539321

metaM glyc3p x
initial concentration: 1.0
name: Glycerol 3-phosphate
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00126
type: Species
is: C00093
is: CHEBI:57597
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093

metaM arg L c
initial concentration: 1.0
is: HMDB00517
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
boundary condition: false
constant: false
type: Species
is: CHEBI:32682
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR r1557
reversible: true
product: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR HEXCCOAtx
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_26ab7e17_3c17_491d_8b8f_01a65e7c732c
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:84002
is: Q9BYG0
initial concentration: NaN
type: Species
name: B3GNT5
has only substance units: false
initial amount: NaN

metaR GCC2cm
product: MODEL1310110010#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110010#
name: glycine-cleavage complex (lipoamide), mitochondrial
is described by: ECO:0000269
fast: false
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110010#
type: Reaction

metaM CE5161 r
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:12947
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
initial concentration: 1.0

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM HC00250 c
has only substance units: false
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
boundary condition: false
constant: false
type: Species
initial amount: NaN
name: hydrosulfide
initial concentration: 1.0
is: CHEBI:29919

http://identifiers.org/biomodels.db/MODEL1310110010#_4e344b14_d4e8_4672_be9b_f9a1035273e6
constant: false
type: Species
is: SBO:0000252
name: GALK2
initial concentration: NaN
is: Q01415
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:2585

metaR r2106
type: Reaction
is: SBO:0000185
modifier: MODEL1310110010#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110010#
product: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110010#
fast: false

metaR HMGLm
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.3.4
type: Reaction
product: MODEL1310110010#
modifier: MODEL1310110010#
name: hydroxymethylglutaryl-CoA lyase
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_9ad7e91d_0818_4dec_b565_bc4d69c2aa8f
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is: Q96I99
is encoded by: hsa:8801
name: SUCLG2
initial concentration: NaN

metaM arg L e
constant: false
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00517
is: CHEBI:32682
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_b6466b76_3a91_4e43_8569_4233c4591d59
is: Q9BWD1
is encoded by: hsa:39
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: ACAT2
type: Species
has only substance units: false
initial amount: NaN

metaR RADH4
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11606944 NOTES:IT
reversible: true
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000000
type: Reaction
name: retinal dehydrogenase (NADPH)
product: MODEL1310110010#

metaM lys L c
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00182
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
is: SBO:0000247
has only substance units: false
name: L-lysinium(1+)
initial amount: NaN

metaM gdp m
is: SBO:0000247
is: CHEBI:58189
initial concentration: 1.0
has only substance units: false
is: C00035
is: HMDB01201
type: Species
constant: false
boundary condition: false
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_398ff600_bc15_4bd6_a983_30ee7ad6b670
name: HSD17B4
initial amount: NaN
constant: false
is: E9PB82
initial concentration: NaN
is encoded by: hsa:3295
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_afa7a0b8_e44d_4e40_b695_ef3817c2e9c7
is encoded by: hsa:9651
initial amount: NaN
name: PLCH2
is: O75038
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_894547d0_b8f0_4e4e_916d_fa79938b8abf
initial amount: NaN
name: ADH1C
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:126
initial concentration: NaN
is: P00326
boundary condition: true

metaR RE3001M
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.34
kinetic law: MODEL1310110010#
name: RE3001
is: SBO:0000176
reversible: true
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000

metaM dolp U r
has only substance units: false
type: Species
name: dolichyl phosphate(2-)
boundary condition: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57683

metaR r2199
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
reversible: true
kinetic law: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
modifier: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM g3m8mpdol U r
boundary condition: false
constant: false
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: C05873
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247

metaM h2o2 x
name: Hydrogen peroxide
initial concentration: 1.0
is: CHEBI:16240
is: C00027
is: SBO:0000247
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
type: Species
is: HMDB03125
initial amount: NaN
constant: false

metaR XOL27OHtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
name: 27 hydroxy cholesterol transport
is: SBO:0000185
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
reversible: true
fast: false
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_a8e41dd0_8869_4f79_b626_a596c5e55322
name: NT5M
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:56953
is: Q9NPB1
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaM ala L e
constant: false
is: HMDB00161
type: Species
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
name: L-alanine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16977

metaR r2089
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110010#
modifier: MODEL1310110010#

metaM tre e
is: HMDB00975
name: Trehalose
type: Species
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
is: SBO:0000247
boundary condition: false
is: CHEBI:16551
is: C01083
has only substance units: false
constant: false
initial amount: NaN

metaR NADHtpu
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110010#
fast: false
name: NADH transporter, peroxisome
is: SBO:0000185
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM h2o2 m
constant: false
boundary condition: false
type: Species
is: C00027
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
is: CHEBI:16240
initial amount: NaN
initial concentration: 1.0
is: HMDB03125
is: SBO:0000247

metaR r2323
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
is: SBO:0000185

metaM glu5sa m
type: Species
is: C01165
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
constant: false
has only substance units: false
name: L-Glutamate 5-semialdehyde
is: HMDB02104
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:17232

http://identifiers.org/biomodels.db/MODEL1310110010#_a48c023e_e034_43a9_8e9f_4e5c7e7c08a1
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:229
has only substance units: false
name: ALDOB
is: P05062
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_ea6a81c5_e44b_4c00_934c_14792558dcfa
is encoded by: hsa:BE966236
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: _BE966236_1_m
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_59002d85_7c7f_46eb_96c6_dc31ffddfd9b
is: Q9Y6T7
has only substance units: false
is encoded by: hsa:1607
is: SBO:0000252
name: DGKB
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_9453778d_8754_437c_a2c9_1cd614df2b73
is: SBO:0000252
name: _NOS2A_1_c
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:NOS2A

metaM zym int2 r
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:52386
has only substance units: false
name: zymosterol intermediate 2
constant: false
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_e13d32a3_45a8_4bee_b88d_83ad905a8dfc
initial concentration: NaN
boundary condition: true
has only substance units: false
name: MTHFD2
is: P13995
type: Species
initial amount: NaN
is encoded by: hsa:10797
is: SBO:0000252
constant: false

metaR r0384
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176

metaM drib c
is: CHEBI:28816
constant: false
initial concentration: 1.0
name: 2-deoxy-D-ribose
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB03224
initial amount: NaN
has only substance units: false

metaR PSt3
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
name: phosphatidylserine transport
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

metaR RETH
fast: false
reversible: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
is version of: http://identifiers.org/ec-code/3.1.1.3
product: MODEL1310110010#
is described by: ECO:0000000
name: retinyl ester hydrolase
reactant: MODEL1310110010#

metaM ksi pre4 g
is: HMDB00175
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 4
is: CHEBI:58053
is: C00130
boundary condition: false
notes: FORMULA: C101H165N7O72X CHARGE: -1

metaM lys L n
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00182
is: CHEBI:32551
initial concentration: 1.0
has only substance units: false

metaR GLYCTO1p
is version of: http://identifiers.org/ec-code/1.1.3.15
reversible: false
type: Reaction
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
product: MODEL1310110010#
name: Glycolate oxidase, peroxisome
fast: false
is described by: ECO:0000269

metaM cyan e
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:18407
name: hydrogen cyanide
constant: false
is: HMDB02084
is: SBO:0000247

metaR CSNt
modifier: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
name: cytosine transport via facilated diffusion

metaR PSSA1 hs
is described by: ECO:0000269
name: Phosphatidylserine synthase homo sapiens
fast: false
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.8.29
product: MODEL1310110010#
reversible: true
is: SBO:0000176
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
type: Reaction

metaR RETH2e
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
name: retinyl ester hydrolase (11-cis), extracellular
is described by: ECO:0000000
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_2b7ad3de_c1e1_42d0_a9ce_ed2c4152b529
is: Q53YB7
name: COX5B
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:1329
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaM 10fthf m
type: Species
boundary condition: false
constant: false
is: HMDB00972
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
name: 10-formyltetrahydrofolate(2-)
is: CHEBI:57454
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR r2088
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: true
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110010#

metaM digalside hs g
is: http://identifiers.org/pubchem.compound/8383
initial amount: NaN
boundary condition: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
is: C06126
constant: false
is: SBO:0000247
has only substance units: false
name: Digalactosylceramide
initial concentration: 1.0
type: Species

metaR 34DHOXPEGt
is described by: ECO:0000000
fast: false
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
is: SBO:0000185
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_12e13b40_107b_4fec_adf6_bd85a3d62645
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is: A5PKZ1
boundary condition: true
name: GALNT5
is encoded by: hsa:11227

metaM 6pgl r
boundary condition: false
type: Species
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
is: HMDB01127
is: CHEBI:57955
initial amount: NaN

metaR r0780
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110010#
reactant: MODEL1310110010#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70

metaM 5adtststerones e
has only substance units: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
initial concentration: 1.0
is: HMDB06278

metaM ade c
type: Species
is: CHEBI:16708
is: C00147
has only substance units: false
is: HMDB00034
is: SBO:0000247
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: Adenine

http://identifiers.org/biomodels.db/MODEL1310110010#_8c15f793_71f0_4878_8e4f_e1e06313bc31
is encoded by: hsa:6579
has only substance units: false
initial concentration: NaN
type: Species
is: P46721
boundary condition: true
initial amount: NaN
constant: false
name: SLCO1A2
is: SBO:0000252

metaR r2324
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaR r1492
reversible: false
name: Utilized transport
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction

metaM lys L m
has only substance units: false
boundary condition: false
is: CHEBI:32551
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)

metaR H2O2t
is described by: ECO:0000000
name: hydrogen peroxide transport via diffusion
kinetic law: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
product: MODEL1310110010#
fast: false
is: SBO:0000185

metaM ala L c
is: HMDB00161
is: CHEBI:16977
name: L-alanine
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR 41R1H2MAE12BOOX
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
kinetic law: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#

metaM 5fthf m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01562
name: 5-formyltetrahydrofolate(2-)
is: CHEBI:57457
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_9c3d8831_5c92_49c6_879c_8d5cea003226
is: P00374
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: DHFR
initial concentration: NaN
is encoded by: hsa:1719
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_fb552636_d998_46af_8720_c05e5a540810
initial concentration: NaN
is: Q96AT9
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: RPE
is encoded by: hsa:6120

metaR r1400
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: false
name: Active transport

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR ICDHyrm
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reversible: true
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: Isocitrate dehydrogenase (NADP+)
product: MODEL1310110010#
fast: false

metaR r0027
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
type: Reaction
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.14.13.39
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000176
reversible: true
product: MODEL1310110010#
is described by: ECO:0000000
modifier: MODEL1310110010#

metaM cyan c
initial amount: NaN
name: hydrogen cyanide
constant: false
is: CHEBI:18407
is: HMDB02084
is: SBO:0000247
has only substance units: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
boundary condition: false
type: Species
initial concentration: 1.0

metaM 42A3HP24DB c
has only substance units: false
constant: false
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
boundary condition: false
is: HMDB04083
is: SBO:0000247
initial amount: NaN
type: Species
is: C05645
initial concentration: 1.0
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: http://identifiers.org/pubchem.compound/7956

metaR BPNT
is described by: ECO:0000269
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110010#
name: 3',5'-bisphosphate nucleotidase
is version of: http://identifiers.org/ec-code/3.1.3.7

metaM phytcoa c
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
initial concentration: 1.0
is: HMDB01359
is: SBO:0000247
has only substance units: false
is: CHEBI:57391
name: phytanoyl-CoA(4-)
type: Species
constant: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_49c33d66_2c4d_4f76_be81_3b138b18e4fd
name: _J03866_1_m
boundary condition: true
is encoded by: hsa:J03866
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaM malcoa r
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01175
name: malonyl-CoA(4-)
initial amount: NaN
is: CHEBI:57384
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
type: Species
constant: false
has only substance units: false

metaM nad x
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Nicotinamide adenine dinucleotide
is: C00003
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305
is: HMDB00902
type: Species
initial amount: NaN
is: CHEBI:57540

metaM thcholoylcoa x
is: CHEBI:27403
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
is: HMDB12456
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: SBO:0000247
type: Species
boundary condition: false

metaM drib e
is: HMDB03224
boundary condition: false
initial concentration: 1.0
is: CHEBI:28816
constant: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
name: 2-deoxy-D-ribose

metaM nadh x
boundary condition: false
is: HMDB01487
is: C00004
is: CHEBI:57945
type: Species
is: http://identifiers.org/pubchem.compound/3306
name: Nicotinamide adenine dinucleotide - reduced
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR r0781
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
product: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110010#_c37780fd_f084_4b5b_8e47_08a34f5a8cad
constant: false
initial amount: NaN
name: HMGCL
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:3155
is: Q6IBC0
has only substance units: false
boundary condition: true

metaM ksii core4 l
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
boundary condition: false
is: HMDB01014
name: keratan sulfate II (core 4-linked)
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57255

metaR r2325
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
type: Reaction

metaR r2109
type: Reaction
modifier: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#

metaR r1495
kinetic law: MODEL1310110010#
reversible: false
is described by: ECO:0000000
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
product: MODEL1310110010#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
reactant: MODEL1310110010#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_e1559b42_095f_430b_8251_7dc945fef601
name: IDH2
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3418
initial concentration: NaN
boundary condition: true
constant: false
is: P48735
initial amount: NaN

metaR FACOAL245 1
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110010#
reversible: true
name: fatty-acid--CoA ligase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction

metaR FACOAL245 2
reversible: true
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
is: SBO:0000176
type: Reaction

metaR FAOXC18480m
modifier: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
is described by: ECO:0000000
kinetic law: MODEL1310110010#

metaM fad e
is: HMDB01248
initial concentration: 1.0
type: Species
constant: false
is: C00016
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized

metaR r1401
modifier: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.10.1
kinetic law: MODEL1310110010#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.2.1.35
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
reversible: false
type: Reaction
fast: false
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.51

metaM 4mzym int2 r
name: 4-Methylzymosterol intermediate 2
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
is: HMDB06838

metaM clpndcoa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
initial concentration: 1.0
boundary condition: false
is: HMDB06267
has only substance units: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/47205476
is: C16166
constant: false
initial amount: NaN
name: clupanodonyl CoA

metaR r0385
reversible: false
reactant: MODEL1310110010#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is: SBO:0000176

metaM citr L m
is: CHEBI:16349
type: Species
is: HMDB00904
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
name: L-citrulline
initial amount: NaN

metaR CORE2GTg
reactant: MODEL1310110010#
reversible: false
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110010#

metaM c226crn c
name: cervonyl carnitine
is: HMDB06510
boundary condition: false
constant: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/127055
is: SBO:0000247

metaR ACCOAC
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR RE3628M
is: SBO:0000176
reversible: true
name: RE3628
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110010#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000

metaR r2326
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110010#

metaM ade e
is: HMDB00034
is: CHEBI:16708
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: adenine
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
type: Species

metaR RE3242R
is: SBO:0000176
type: Reaction
reversible: true
name: RE3242
modifier: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

metaR q10h2tc
reversible: true
type: Reaction
name: transport of ubiquinol into cytosol
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaM cholcoa r
is: CHEBI:57373
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
type: Species
name: choloyl-CoA(4-)
is: HMDB01374
boundary condition: false
is: SBO:0000247

metaM Lcystin e
name: L-cystine
type: Species
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
is: CHEBI:16283
is: SBO:0000247
is: HMDB00192
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_3266ef3d_073e_4e8a_81fa_bf9439954dc2
name: ACSL4
initial amount: NaN
is: SBO:0000252
is: O60488
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:2182
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_8d861f41_11e5_4f60_8bb4_fbd8e2cd37b3
initial concentration: NaN
type: Species
name: _U37519_1_c
has only substance units: false
is encoded by: hsa:U37519
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_dc5a2ab0_252e_42d9_a690_0d30fde6d5d0
initial concentration: NaN
is encoded by: hsa:5230
is: P00558
constant: false
initial amount: NaN
name: PGK1
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaR FUCASE2ly
type: Reaction
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.51
fast: false
kinetic law: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
name: alpha-fucosidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#

metaR r0783
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_4e836967_4101_439c_b923_36c1e0178e13
name: SDHC
has only substance units: false
is encoded by: hsa:6391
boundary condition: true
type: Species
is: Q99643
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR r2085
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110010#
product: MODEL1310110010#
fast: false

metaR r1827
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_c3dcfb09_3f27_4280_bb30_dbf8fa209fc6
name: RPN1
initial concentration: NaN
is: P04843
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:6184
boundary condition: true

metaR r0706
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.10
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_0f732b90_6537_4c40_8df2_b73c27674611
constant: false
is encoded by: hsa:221
name: ALDH3B1
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P43353
has only substance units: false
initial concentration: NaN

metaR HMGCOARc
is: SBO:0000176
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
type: Reaction
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.34
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).

metaR LNLCt
type: Reaction
fast: false
reversible: true
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110010#
name: Linoleic acid (n-C18:2) transport in via diffusion

metaR r1551
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110010#
type: Reaction

metaR r0021
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
modifier: MODEL1310110010#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
type: Reaction
product: MODEL1310110010#
is: SBO:0000176

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_ff902f1f_4745_4bfb_a346_d4cf6044d9bf
constant: false
is: P07195
name: LDHB
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3945
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM dhap e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57642
is: HMDB01473
name: glycerone phosphate(2-)
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111

metaM nadh r
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: NADH(2-)
has only substance units: false
is: CHEBI:57945
is: SBO:0000247
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: HMDB01487

metaM 5oxpro e
initial concentration: 1.0
boundary condition: false
is: CHEBI:57606
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00267
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
constant: false
name: 5-oxoprolinate

metaM nad r
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
name: NAD(1-)
type: Species
constant: false
is: CHEBI:57540
is: HMDB00902
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_b85c08b5_c3c0_4633_a80b_286534c6b18e
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: TXNRD1
is encoded by: hsa:7296
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_845e7dd0_bc93_4402_946d_d20f082a0d9a
initial amount: NaN
initial concentration: NaN
is: Q9HAS3
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:64078
boundary condition: true
name: SLC28A3

metaR r0784
product: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
fast: false

metaR G14T3g
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110010#
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110010#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176

metaR r2320
product: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
is: SBO:0000185

metaM digalside hs c
is: C06126
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
name: Digalactosylceramide
type: Species
is: http://identifiers.org/pubchem.compound/8383

metaR r2084
modifier: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110010#
fast: false
type: Reaction
kinetic law: MODEL1310110010#
reversible: true
is described by: ECO:0000000

metaM fad c
has only substance units: false
is: C00016
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
is: CHEBI:16238
is: HMDB01248

metaM gdp g
initial amount: NaN
name: GDP(3-)
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
initial concentration: 1.0
is: HMDB01201
is: SBO:0000247
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_d7c3af33_c4c7_429e_820b_e97580ee36b9
is encoded by: hsa:1633
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: DCK
is: P27707

metaM acac c
name: acetoacetate
initial concentration: 1.0
is: HMDB00060
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
has only substance units: false
is: CHEBI:13705
type: Species
boundary condition: false

metaR THFtm
reactant: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110010#_4aea220b_fd70_4e48_a3a9_cb840f8fec27
has only substance units: false
constant: false
initial amount: NaN
name: GLRX2
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:51022

http://identifiers.org/biomodels.db/MODEL1310110010#_3610dcfd_28a4_4985_b92b_d384b334c3a5
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AI971036
name: _AI971036_1_c
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaR r1552
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110010#
is described by: ECO:0000000

metaM HC01496 m
has only substance units: false
name: 2-Amino-3-oxoadipate
is: CHEBI:28095
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

metaR MDHm
is described by: ECO:0000134
kinetic law: MODEL1310110010#
reversible: true
product: MODEL1310110010#
is: SBO:0000176
name: malate dehydrogenase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.37
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
reactant: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#

metaR SIAT4Bg
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
is described by: ECO:0000269
reversible: false
type: Reaction
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.4
product: MODEL1310110010#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_8601a262_78b1_4d35_9cfb_a6266940f1e7
has only substance units: false
is encoded by: hsa:MBOAT5
is: SBO:0000252
boundary condition: true
name: _MBOAT5_1_c
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaR r2321
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110010#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110010#
product: MODEL1310110010#

metaM CE2705 c
boundary condition: false
initial concentration: 1.0
name: quinonoid dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: CHEBI:36781
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_d5081d62_05a5_4df1_89d9_16862970a000
is: Q9NYQ3
has only substance units: false
is encoded by: hsa:51179
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: HAO2
initial concentration: NaN
constant: false

metaR PHCDm
is described by: ECO:0000304
is: SBO:0000176
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
type: Reaction
reversible: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_bb2cf2d9_9a52_4aa3_8e8c_74fd2b7b8a39
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: ACO2
is: SBO:0000252
is: Q99798
has only substance units: false
is encoded by: hsa:50

metaR r1825
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_1c84a5e0_aef3_4fd9_9994_8e2232ad1657
has only substance units: false
boundary condition: true
is encoded by: hsa:8395
initial concentration: NaN
is: O14986
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: PIP5K1B

metaM lgnccoa x
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: lignocericyl coenzyme A
is: HMDB06526
initial amount: NaN
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1

metaR r2087
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_d115935d_f2e2_4f77_bb74_afe902138d96
is encoded by: hsa:314
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: O75106
name: AOC2

metaR CYTK1n
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
product: MODEL1310110010#
is: SBO:0000176
reversible: true
type: Reaction
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

metaM nadph x
is: SBO:0000247
initial amount: NaN
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
has only substance units: false
is: C00005
is: HMDB00221
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
constant: false
boundary condition: false

metaR 41R2A1H12BOOX
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
modifier: MODEL1310110010#
type: Reaction
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000269
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#

metaM frdp r
name: Farnesyl diphosphate
initial amount: NaN
boundary condition: false
is: C00448
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
constant: false
is: SBO:0000247
is: CHEBI:175763
is: HMDB00961
has only substance units: false
type: Species
initial concentration: 1.0

metaR P4508B13r
name: sterol 12-alpha-hydroxylase (nadh)
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.95
type: Reaction
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
product: MODEL1310110010#
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_ede5076c_10ca_4d62_9406_2bb60ec291ec
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:29968
type: Species
boundary condition: true
is: SBO:0000252
is: Q9Y617
name: PSAT1
initial amount: NaN

metaR H2O2syn
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES:SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.6.3.1
is: SBO:0000176
is described by: ECO:0000304
reversible: false
name: Hydrogen peroxide synthesis (NADPH dependent)
type: Reaction
reactant: MODEL1310110010#
modifier: MODEL1310110010#

metaM nadp c
is: HMDB00217
type: Species
constant: false
is: C00006
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
initial amount: NaN
is: CHEBI:58349
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate

metaR PNTEH
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
is version of: http://identifiers.org/ec-code/3.5.1.92
product: MODEL1310110010#
is: SBO:0000176
fast: false
reversible: false
name: Hydrolase Class ( RXN R02973)
type: Reaction
is described by: ECO:0000269

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
type: Species
is: C06028
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27969
name: Mesaconyl-CoA

metaR r0660
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
modifier: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110010#

metaR r2322
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_d2086b7c_bbc9_47bd_83c1_066ad90354ad
has only substance units: false
is encoded by: hsa:56954
is: Q9NQR4
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: NIT2
is: SBO:0000252
boundary condition: true

metaM ksi deg40 l
is: HMDB00143
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C40H68N2O31 CHARGE: 0
boundary condition: false
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: keratan sulfate I, degradation product 40

metaR r0236
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
type: Reaction
reactant: MODEL1310110010#
modifier: MODEL1310110010#

metaM dhap c
constant: false
initial amount: NaN
is: C00111
type: Species
initial concentration: 1.0
is: HMDB01473
name: Dihydroxyacetone phosphate
is: CHEBI:57642
is: http://identifiers.org/pubchem.compound/3411
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_27deb54f_68a4_4317_966e_caf0ae82d352
name: SULT1A3
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6818
has only substance units: false
constant: false
initial amount: NaN
is: P50224
is: SBO:0000252

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR S6T7g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#

metaR r2086
is: SBO:0000185
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR PRO1x
modifier: MODEL1310110010#
is described by: ECO:0000134
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.5.99.8
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110010#
name: L-ProlineNAD+ 5-oxidoreductase
reversible: false

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaM arg L m
boundary condition: false
is: HMDB00517
is: CHEBI:32682
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
is: SBO:0000247
constant: false
name: L-argininium(1+)
type: Species

metaR r0022
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
kinetic law: MODEL1310110010#
type: Reaction

metaR FAS140COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110010#
reversible: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000269
reactant: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C14:0CoA)
type: Reaction
is: SBO:0000176

metaM maltttr e
type: Species
is: SBO:0000247
constant: false
is: C02052
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5141
is: HMDB01296
name: Maltotetraose
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
initial concentration: 1.0
initial amount: NaN

metaR FUMSO3tm
type: Reaction
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:sulfite antiport, mitochondrial
reversible: true
modifier: MODEL1310110010#

metaM thcholstoic x
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
is: HMDB03873
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false

metaR APOCF
product: MODEL1310110010#
name: Apocarboxylase formation
type: Reaction
reactant: MODEL1310110010#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
reversible: false
kinetic law: MODEL1310110010#

metaR r0661
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110010#
reactant: MODEL1310110010#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false

metaR 5ADTSTSTERONESte
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
kinetic law: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
name: sulfonated testosterone transport
reversible: true
is: SBO:0000185
fast: false

metaR DNDPt36m
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
is described by: ECO:0000269
product: MODEL1310110010#
is: SBO:0000185
name: dGDP transport via dCDP antiport
type: Reaction
kinetic law: MODEL1310110010#

metaR RE1845C
modifier: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110010#
name: RE1845
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
kinetic law: MODEL1310110010#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110010#

metaM gua c
constant: false
initial concentration: 1.0
is: C00242
name: Guanine
is: CHEBI:16235
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: HMDB00132
is: SBO:0000247

metaM q10 c
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: SBO:0000247
is: HMDB01072
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: ubiquinone-10
initial amount: NaN
type: Species
is: CHEBI:46245

metaR FACOAL160i
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is: SBO:0000176
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
name: C160 fatty acid activation
reversible: false

metaM 6thf e
type: Species
is: SBO:0000247
initial amount: NaN
name: hexaglutamyl folate (THF)
initial concentration: 1.0
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: http://identifiers.org/pubchem.compound/169691
boundary condition: false
has only substance units: false
constant: false

metaR TSULt4 3
type: Reaction
modifier: MODEL1310110010#
product: MODEL1310110010#
name: thiosulfate transport via sodium symport
kinetic law: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
fast: false
reversible: true
reactant: MODEL1310110010#

metaR CHAT
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is version of: http://identifiers.org/ec-code/2.3.1.6
name: Choline O-acetyltransferase
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#

metaM triodthy c
name: 3,3',5-triiodo-L-thyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:18258
initial concentration: 1.0
is: HMDB00265

metaM spc hs e
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445
type: Species
initial amount: NaN
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
name: sphingosylphosphorylcholine
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_46bb0980_2549_4a8b_aa72_a6c29b0998bf
constant: false
name: _AI656480_1_m
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI656480
has only substance units: false

metaM n2m2mn l
is: SBO:0000247
is: CHEBI:16680
type: Species
initial concentration: 1.0
is: HMDB00939
notes: FORMULA: C42H71N3O31 CHARGE: 0
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_2148a0b4_c075_4d58_820d_452052f6718c
is: SBO:0000252
name: ATP2B2
is encoded by: hsa:491
type: Species
initial amount: NaN
boundary condition: true
is: Q4J699
constant: false
initial concentration: NaN
has only substance units: false

metaR CYTK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: true
type: Reaction
name: cytidylate kinase (CMP,UTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110010#

metaR r2094
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#

metaR GALt4
name: galactose transport via sodium symport
is described by: ECO:0000269
reactant: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110010#

metaR FUMTSULtm
is described by: ECO:0000269
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
name: Fumarate:thiosulfate antiport, mitochondrial
modifier: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_d9345c81_2981_4ff3_8fd9_524fe2dc11b1
name: ADH7
is: P40394
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:131
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_1fd369b2_b1a9_46e0_865d_7944c344dfb9
has only substance units: false
type: Species
name: CHST4
boundary condition: true
is: SBO:0000252
is: Q8NCG5
initial amount: NaN
is encoded by: hsa:10164
initial concentration: NaN
constant: false

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR DCK2n
fast: false
name: Deoxycytidine kinase, nuclear (UTP)
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is version of: http://identifiers.org/ec-code/2.7.1.74

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM tetpent3coa c
is: C16167
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: tetracosapentaenoyl coenzyme A, n-3
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
type: Species
has only substance units: false

metaR LNLCCPT1
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_38c8b425_64d9_4271_b91e_4da53bd985ba
boundary condition: true
name: MBOAT2
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q6ZWT7
is encoded by: hsa:129642
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_dd9f352e_4113_435d_8e88_32e4262d855e
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:8309
name: ACOX2
is: Q99424

metaM HC01408 m
boundary condition: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:27648
name: 3-Oxohexanoyl-CoA
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_4f384dcf_2da8_45b1_942e_5faffb30ef17
is: SBO:0000252
type: Species
is encoded by: hsa:10195
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: ALG3

metaR r0434
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is: SBO:0000176
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#

metaM ksii core2 e
initial concentration: 1.0
boundary condition: false
is: HMDB00211
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: CHEBI:17268
initial amount: NaN

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_44bb41ac_529a_435f_b256_7075276fa0e3
constant: false
initial amount: NaN
name: GLDC
is: P23378
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2731
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_c576adea_ec20_4f38_9d94_4518280324f6
initial concentration: NaN
is encoded by: hsa:1376
is: P23786
name: CPT2
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r2341
reactant: MODEL1310110010#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: true
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR CYTK8
is: SBO:0000176
name: cytidylate kinase (CMP,dATP)
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaM prpp e
is: CHEBI:58017
boundary condition: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
is: SBO:0000247
has only substance units: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00280

http://identifiers.org/biomodels.db/MODEL1310110010#_a2de5bf9_25ce_4f14_b676_91647cb7b351
is encoded by: hsa:33
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: ACADL
is: P28330
boundary condition: true

metaR Q10H2e
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
reversible: true
product: MODEL1310110010#
name: transport of ubiquinol into lymph
is described by: ECO:0000134
kinetic law: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
fast: false

metaR r2095
reversible: true
modifier: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_e363cc2f_2248_4231_8868_b67b1c4b5367
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:AI480132
boundary condition: true
is: SBO:0000252
name: _AI480132_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_de4c0204_96c8_438d_ba3b_7350ebe5257d
name: FUT8
is: SBO:0000252
is: B4DFS7
is encoded by: hsa:2530
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaR r2012
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
fast: false
modifier: MODEL1310110010#

metaR NACHEXA15ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110010#
reversible: false
is: SBO:0000176
reactant: MODEL1310110010#
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaR FAS100COA
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
name: fatty acyl-CoA synthase (n-C10:0CoA)
modifier: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_a272acbe_c059_404e_a64f_12189a3bab9b
constant: false
is: SBO:0000252
is: P27144
boundary condition: true
name: AK4
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:205

metaM acnacngalgbside hs c
is: C00036
type: Species
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: HMDB00223
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:3338
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: disialyl galactosylgloboside

metaM q10 e
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:46245
is: HMDB01072
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
name: ubiquinone-10

metaR M16N6Tg
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.155
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4249.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.155 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110010#
name: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
type: Reaction
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
fast: false

metaR LNLCCPT2
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_971caa06_6519_4e6c_9e3b_080f9ed33151
is: SBO:0000252
is: O95477
is encoded by: hsa:19
name: ABCA1
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaR SPH1Pte
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
reversible: true
name: sph1p transport
product: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ

metaR CYSSNAT5tc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r2092
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR RE2814R
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is described by: ECO:0000000
name: RE2814
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000176
reactant: MODEL1310110010#
product: MODEL1310110010#

metaR PAPStg
reactant: MODEL1310110010#
type: Reaction
name: 3'-Phosphoadenylyl sufate Golgi transport
is: SBO:0000185
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
fast: false
modifier: MODEL1310110010#

metaM coa c
type: Species
is: CHEBI:3312
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: HMDB01423
boundary condition: false
is: C00010
name: Coenzyme A
initial amount: NaN
constant: false
is: SBO:0000247

metaM lnlccoa c
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
name: linoleic coenzyme A
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
is: HMDB01064
type: Species
is: SBO:0000247

metaR ASCBt
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
name: L-ascorbate transport via facilitated diffusion
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
reversible: true
fast: false
type: Reaction

metaM etoh e
name: ethanol
is: HMDB00108
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:16236

metaM thf c
initial amount: NaN
constant: false
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
name: 5,6,7,8-Tetrahydrofolate
is: HMDB01846
is: CHEBI:57453
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_7ee6faf6_d11e_41ef_a901_55770722fd68
name: DAD1
is encoded by: hsa:1603
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: Q53G02

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

metaR CYTK9
name: cytidylate kinase (CMP,dCTP)
modifier: MODEL1310110010#
fast: false
is: SBO:0000176
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_d09c64bf_dd18_4a7c_8a4d_cbc5b64d31c1
is: SBO:0000252
is encoded by: hsa:160851
name: DGKH
constant: false
initial amount: NaN
is: Q86XP1
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

metaM tmndnccoa c
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
name: timnodonyl coenzyme A
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: HMDB06514
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_c73c3e4f_7f80_49eb_ad1c_dee86461bc9b
has only substance units: false
type: Species
name: _AI285872_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:AI285872
is: SBO:0000252

metaM dcdp c
boundary condition: false
is: CHEBI:58593
is: C00705
name: dCDP
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB01245
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_99947384_7a3f_47c4_b12f_1ec0833e6cdb
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: ALPI
is: P09923
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:248

metaM atp c
is: HMDB00538
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
name: ATP(4-)
is: C00002
is: CHEBI:30616
type: Species
initial amount: NaN

metaR ALOX52
is version of: http://identifiers.org/ec-code/1.13.11.34
name: Arachidonate 5-lipoxygenase
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
modifier: MODEL1310110010#
reversible: false

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM HC02202 c
type: Species
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial amount: NaN
constant: false
is: CHEBI:57398
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_aa8fa6f0_dc45_4643_8d33_c838a7fe3914
initial concentration: NaN
is encoded by: hsa:25769
has only substance units: false
is: SBO:0000252
constant: false
is: Q9UI40
initial amount: NaN
name: SLC24A2
type: Species
boundary condition: true

metaR r2093
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaM lald D c
type: Species
is: CHEBI:17167
initial concentration: 1.0
name: (R)-lactaldehyde
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: SBO:0000247
is: HMDB06458
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaR r2014
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110010#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_a02a82e7_4e7c_4118_b64c_be3d82b48b5d
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:84105
is: Q9H0N5
constant: false
boundary condition: true
initial amount: NaN
name: PCBD2

http://identifiers.org/biomodels.db/MODEL1310110010#_4888127e_f71c_4e58_b417_7ace3a7459c3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ST3GAL1
is encoded by: hsa:6482
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR RE1448N
kinetic law: MODEL1310110010#
is: SBO:0000176
name: RE1448
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reactant: MODEL1310110010#
type: Reaction
reversible: true

metaM ksi deg6 l
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 6
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C210H336N15O184S11 CHARGE: -11

metaR RE3626M
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
reversible: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110010#
product: MODEL1310110010#
name: RE3626

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

metaR TCHOLAtx
name: bile acid intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000185
product: MODEL1310110010#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110010#

metaR 34HPPte
reversible: true
fast: false
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000134
reactant: MODEL1310110010#
is: SBO:0000185
name: Transport of 3-(4-hydroxyphenyl)pyruvate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_396e3221_f6f4_4a17_af85_9701e14015c6
has only substance units: false
is encoded by: hsa:123041
type: Species
initial concentration: NaN
name: SLC24A4
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_00e9603f_b428_49ec_bc4a_b4c228a5dfbe
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: _NM_013421_1_m
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:NM 013421
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_851f1f53_2fa5_4ee5_8dfb_d21807f62d14
constant: false
is: Q11203
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ST3GAL3
is encoded by: hsa:6487
boundary condition: true

metaR r1260
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110010#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110010#
name: EC:6.2.1.3
reactant: MODEL1310110010#
reversible: false

metaM but c
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: butyrate
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
initial amount: NaN
initial concentration: 1.0

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM etoh c
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
type: Species
initial amount: NaN
is: HMDB00108
is: CHEBI:16236
name: ethanol

metaR NACHEXA20ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
reversible: false

metaM thf e
is: CHEBI:57453
boundary condition: false
type: Species
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
is: HMDB01846
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_af544682_33c6_474b_b9f6_d77b27d115ba
name: LEFTY1
boundary condition: true
constant: false
is: SBO:0000252
is: O75610
initial amount: NaN
type: Species
is encoded by: hsa:10637
has only substance units: false
initial concentration: NaN

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaR RE2986X
modifier: MODEL1310110010#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110010#
name: RE2986
reactant: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is: SBO:0000176

metaR CYTK3
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110010#
name: cytidylate kinase (CMP)(GTP)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_d7657530_4c56_4fba_b7f5_4bf462009445
is: SBO:0000252
is encoded by: hsa:54677
name: CROT
constant: false
is: E7EQF2
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaR r2090
kinetic law: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
type: Reaction

metaM thyox L c
is: SBO:0000247
has only substance units: false
name: L-thyroxine
is: HMDB00248
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:18332
type: Species
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849

metaM HC02202 e
is: SBO:0000247
type: Species
is: CHEBI:57398
name: prostaglandin A1(1-)
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_66cbd4cf_40d8_416e_8f7a_0503eec14e5d
is: SBO:0000252
type: Species
is encoded by: hsa:4047
boundary condition: true
is: E9PEI9
constant: false
name: LSS
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR LEUKTRD4t
is: SBO:0000185
name: leukotriene D4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM leuktrA4 c
boundary condition: false
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN
is: CHEBI:57463
is: HMDB01337
is: SBO:0000247
constant: false
name: leukotriene A4(1-)
initial concentration: 1.0
type: Species

metaM atp e
constant: false
is: SBO:0000247
is: C00002
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
name: ATP(4-)
initial amount: NaN
is: CHEBI:57299
is: HMDB00538

metaM core3 g
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16250
initial concentration: 1.0
name: Core 3
type: Species
notes: FORMULA: C16H27N2O10X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110010#_36639b9b_f589_4688_907c_e393cb8a0677
is: SBO:0000252
name: MGAT5
constant: false
boundary condition: true
is: Q09328
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4249
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_a724f0a0_b031_468a_8326_4df42a93a912
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: P49247
initial concentration: NaN
is encoded by: hsa:22934
type: Species
name: RPIA
is: SBO:0000252

metaR SRTNtu
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: Serotonin uniport
is: SBO:0000185
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
modifier: MODEL1310110010#
fast: false
product: MODEL1310110010#
is described by: ECO:0000269
type: Reaction

metaR r1809
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM stcoa c
boundary condition: false
type: Species
initial amount: NaN
name: Stearoyl-CoA (n-C18:0CoA)
is: C00412
is: SBO:0000247
is: CHEBI:57394
constant: false
has only substance units: false
is: HMDB01114
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial concentration: 1.0

metaM xol7ah2 m
initial concentration: 1.0
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha-diol
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:28047
is: HMDB06893
type: Species
is: SBO:0000247

metaR CYTK4
is: SBO:0000176
product: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
name: cytidylate kinase (dCMP)(GTP)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_85409b7b_c456_475c_a9b1_a3258f86699a
name: UCP1
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7350
initial concentration: NaN
type: Species
has only substance units: false
is: P25874
boundary condition: true

metaR r2091
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_a579cc4b_6151_4779_9ada_6fd3858b0ba5
initial amount: NaN
is: SBO:0000252
name: _F23536_1_m
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:F23536
constant: false
type: Species

metaR ENGASE3ly
reactant: MODEL1310110010#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
name: endo-beta-N-acetylglucosaminidase, lysosomal

metaM triodthy e
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
name: 3,3',5-triiodo-L-thyronine
is: SBO:0000247
is: CHEBI:18258
has only substance units: false
boundary condition: false
is: HMDB00265
constant: false

metaR CERT1rt
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
name: ceramide transport protein
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
reactant: MODEL1310110010#
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_4d851785_714f_41a9_811b_cd155ed219e6
is: Q7Z4L0
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:341947
is: SBO:0000252
initial amount: NaN
constant: false
name: COX8C

metaM glac r
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB06355
initial amount: NaN
name: D-glucurono-6,3-lactone
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
has only substance units: false
is: SBO:0000247
is: CHEBI:18268

http://identifiers.org/biomodels.db/MODEL1310110010#_b7c6d50a_bfc9_4c5d_9dd3_d4835fd53f86
type: Species
name: COX4I2
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: Q96KJ9
is encoded by: hsa:84701
initial concentration: NaN
boundary condition: true

metaR DHCHOLESTANATEtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
reactant: MODEL1310110010#
is: SBO:0000185
type: Reaction
product: MODEL1310110010#
fast: false
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110010#
reversible: true

metaM dutp c
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
initial concentration: 1.0
is: HMDB01191
name: dUTP
is: C00460
is: CHEBI:17625
is: SBO:0000247
type: Species

metaR FAOXC2452253x
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:- in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) confusing name, sorry - accounting for omega3 vs omega6 FA peroxisomal (very long chain FA) c24:5,n-3 -> c22:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#

metaM bamppald c
is: C05665
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01106
type: Species
initial concentration: 1.0
name: beta-Aminopropion aldehyde
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
is: http://identifiers.org/pubchem.compound/7975
initial amount: NaN

metaR GALASE11ly
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
is described by: ECO:0000000
is: SBO:0000176

metaR BILGLCURtr
reversible: true
name: glucuronidated compound transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_713dad1b_aabd_4289_890f_92732e27db6f
name: NDUFA6
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:4700
is: SBO:0000252
initial amount: NaN
is: P56556
constant: false

metaR G12MT1 U
reactant: MODEL1310110010#
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#

metaM thyox L e
is: HMDB00248
is: CHEBI:18332
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
has only substance units: false

metaM etha c
has only substance units: false
initial amount: NaN
boundary condition: false
name: etha[c]
constant: false
is: CHEBI:57603
type: Species
initial concentration: 1.0
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
is: SBO:0000247
is: HMDB00149

http://identifiers.org/biomodels.db/MODEL1310110010#_f4349aef_2653_4293_9fa4_b5640af4f539
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q59F77
boundary condition: true
initial amount: NaN
type: Species
name: PLCB2
constant: false
is encoded by: hsa:5330

metaM coa g
is: CHEBI:57287
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
initial amount: NaN
name: coenzyme A(4-)
is: HMDB01423
constant: false
has only substance units: false

metaM spc hs c
name: sphingosylphosphorylcholine
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/5311445

metaM HC01104 e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
type: Species
is: CHEBI:61146
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 4-nitrophenyl phosphate(2-)

metaR CYTK5
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000269
fast: false
product: MODEL1310110010#
type: Reaction
reversible: true
name: cytidylate kinase (dCMP)

metaR r0464
reactant: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
reversible: true
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110010#

metaR r1177
name: EC:3.1.1.13
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_d4fe2146_900d_4692_b01d_b3167ec774ec
is encoded by: hsa:3038
initial amount: NaN
name: HAS3
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q96RV2
has only substance units: false
boundary condition: true
type: Species

metaM ac c
is: HMDB00042
initial amount: NaN
is: CHEBI:30089
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
name: acetate
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

http://identifiers.org/biomodels.db/MODEL1310110010#_fa648cec_8269_467d_97b3_60ada1bb4b62
has only substance units: false
type: Species
initial concentration: NaN
name: SULT1A1
is encoded by: hsa:6817
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR FADH2tx
is described by: ECO:0000000
name: FADH2 transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
reactant: MODEL1310110010#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_37e07701_1a58_4efa_8061_30b6c2ec8378
initial concentration: NaN
is: Q9BWD1
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:39
initial amount: NaN
constant: false
name: ACAT2

metaR LNLNCAt
is: SBO:0000185
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_e452a6ba_017a_4e1d_8c2f_032e4e4c3705
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA177072
initial concentration: NaN
has only substance units: false
name: _AA177072_1_x
constant: false
type: Species
boundary condition: true

metaR 13DAMPPOX
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
kinetic law: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
type: Reaction
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
fast: false
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.4.3.21
product: MODEL1310110010#

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM gcald c
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: CHEBI:17071
has only substance units: false
name: glycolaldehyde
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: HMDB03344
initial amount: NaN
initial concentration: 1.0

metaR TETTET6COAtx
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
name: fatty acid intracellular transport
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110010#

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR CYTK6
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110010#
type: Reaction
name: cytidylate kinase (CMP,CTP)
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000269
fast: false
product: MODEL1310110010#
is: SBO:0000176

metaR FAOXC2252053x
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110010#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false
fast: false
modifier: MODEL1310110010#
product: MODEL1310110010#

metaM ksi pre22 g
initial amount: NaN
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 22
type: Species
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false
constant: false
is: C00130
boundary condition: false
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: SBO:0000247

metaM 4abutn m
name: 4-ammoniobutanal
constant: false
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
type: Species
is: CHEBI:58264
is: HMDB01080
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaM ac e
is: SBO:0000247
constant: false
is: HMDB00042
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
name: acetate

metaR r2443
reversible: false
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
kinetic law: MODEL1310110010#

metaM gluside hs r
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
constant: false
is: CHEBI:18368
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false

metaR TETHEX3COAtx
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true

metaM sphs1p r
is: HMDB00277
initial amount: NaN
name: sphingosine 1-phosphate(1-)
constant: false
is: CHEBI:60119
type: Species
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR GGH 10FTHF7GLUe
is: SBO:0000176
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
is described by: ECO:0000000
reactant: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9

http://identifiers.org/biomodels.db/MODEL1310110010#_015cf8a7_7634_4fc1_bee3_be26cafa691f
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: AADAT
initial amount: NaN
is encoded by: hsa:51166
is: Q4W5N8

metaR P5CRm
modifier: MODEL1310110010#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110010#
name: pyrroline-5-carboxylate reductase (m)
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000176
reversible: false
product: MODEL1310110010#

metaM s2l2n2m2m l
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57312
name: de-Fuc form of PA6 (w/o peptide linkage)
notes: FORMULA: C84H136N6O62 CHARGE: -2
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01356
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_20e60dd7_9a44_4dbd_a599_09981a21d74f
is encoded by: hsa:38
type: Species
is: P24752
constant: false
is: SBO:0000252
name: ACAT1
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaR AG13T17g
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110010#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
modifier: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is: SBO:0000176
fast: false

metaM Rtotal2 c
is: CHEBI:60377
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial concentration: 1.0
name: R total 2 position
is: HMDB00095
initial amount: NaN
is: C00055
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_a99e875f_83be_452c_9ff5_99039cc382ed
is: SBO:0000252
is: Q9Y227
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: ENTPD4
is encoded by: hsa:9583
initial amount: NaN
has only substance units: false

metaR RE1517M
name: RE1517
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
type: Reaction
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaM ksii core2 l
initial amount: NaN
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:57255
constant: false
is: HMDB01014
has only substance units: false
type: Species
initial concentration: 1.0
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_369758cb_439a_48a2_843f_45b448bd19fd
boundary condition: true
is encoded by: hsa:3295
initial amount: NaN
is: E9PB82
name: HSD17B4
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_86b198db_6092_4b67_a72a_11e66129ffa8
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is: G5E960
name: PLCB3
has only substance units: false
is encoded by: hsa:5331

metaR VALPHELAT2tc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM urcan c
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: C00785
is: SBO:0000247
is: HMDB00301
initial amount: NaN
has only substance units: false
boundary condition: false
name: Urocanate
type: Species
initial concentration: 1.0
is: CHEBI:17771
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_44bcfa6d_39aa_46b8_bd10_5d5c5723d746
name: _AI653169_1_c
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI653169
is: SBO:0000252
constant: false
has only substance units: false

metaR r0917
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_f4b5ed03_f8bd_46ce_8dce_b8d397ea3081
is: SBO:0000252
constant: false
has only substance units: false
name: _AA502753_1_m
type: Species
is encoded by: hsa:AA502753
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r1549
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#

metaR RE3272N
name: RE3272
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_0ebdd737_1029_4dc3_850b_5ab87dffb73d
initial amount: NaN
has only substance units: false
is encoded by: hsa:11136
boundary condition: true
is: P82251
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: SLC7A9

metaM trp L e
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
name: L-tryptophan
is: HMDB00929

http://identifiers.org/biomodels.db/MODEL1310110010#_7f97d0a0_292a_448a_8935_d29d24ba695f
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
boundary condition: true
initial amount: NaN
type: Species
name: _HG2846_HT2983_1_c
has only substance units: false

metaR G14T18g
product: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is: SBO:0000176

metaM lnlccoa m
initial amount: NaN
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
constant: false
name: linoleic coenzyme A
initial concentration: 1.0
is: HMDB01064
has only substance units: false
is: SBO:0000247

metaR r0463
is described by: ECO:0000000
fast: false
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000176
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
reversible: true
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
kinetic law: MODEL1310110010#

metaR 5ADTSTSTERONEtr
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000000
product: MODEL1310110010#
name: 5 alpha dihydrotesterone intracellular transport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
kinetic law: MODEL1310110010#

metaR RE2814M
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reactant: MODEL1310110010#
reversible: true
is: SBO:0000176
product: MODEL1310110010#
name: RE2814
kinetic law: MODEL1310110010#
is described by: ECO:0000000

metaM CE5120 m
is: SBO:0000247
name: trans-2-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial amount: NaN
is: CHEBI:12947
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_1e7cb1ec_1337_4477_9716_6fe07ca7373c
is: O14556
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:26330
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: GAPDHS
type: Species

metaR Htg
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
name: proton diffusion (Golgi)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110010#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_cc36bfaa_3dd6_423c_b237_fc07093b4ae0
name: COASY
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:80347
constant: false
type: Species
is: Q13057
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_3f34395e_7d20_49d4_b723_8780a790a788
is encoded by: hsa:125206
boundary condition: true
is: A0PJK1
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: SLC5A10
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_65291589_b52f_465c_bf6c_70f85cc20c8b
initial concentration: NaN
name: _R33828_1_c
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:R33828
constant: false
initial amount: NaN

metaM atp m
is: C00002
constant: false
name: ATP(4-)
is: CHEBI:57299
boundary condition: false
is: HMDB00538
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r2120
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110010#
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110010#

metaM pi x
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:43474
constant: false
is: HMDB00973
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_cd0c72b9_9120_4a43_8d0f_fd470700418c
initial concentration: NaN
name: MBOAT7
boundary condition: true
is: Q96N66
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:79143
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_b0af1698_645b_4b61_bb24_f4ae021ed18c
is: Q6I9V5
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:293
name: SLC25A6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_79ce6e38_924b_4bb2_8d4a_f1f2fe49e60f
has only substance units: false
name: GALNT11
is: B3KWF4
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:63917
boundary condition: true

metaR GCC2bim
product: MODEL1310110010#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
modifier: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is: SBO:0000176
reversible: false

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
product: MODEL1310110010#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction

metaR MAN1PT2
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
type: Reaction
reversible: false
modifier: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
name: mannose-1-phosphate guanylyltransferase (GDP)
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.7.13
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ebc1f1df_e689_47a5_a014_ffe2cf998174
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: O43677
is encoded by: hsa:4717
initial amount: NaN
initial concentration: NaN
name: NDUFC1

metaR NDPK1m
kinetic law: MODEL1310110010#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
is: SBO:0000176
reactant: MODEL1310110010#
type: Reaction
fast: false
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000254
product: MODEL1310110010#

metaR LEUTAm
name: leucine transaminase, mitochondrial
type: Reaction
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
product: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_a218e848_ae1c_44d9_ad8f_1e1691297454
is: SBO:0000252
constant: false
initial concentration: NaN
name: ELOVL1
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:64834
initial amount: NaN
is: Q9BW60

metaR PAIL HStn
reversible: true
name: phosphatidylinositol nuclear transport (diffusion)
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_03fc3390_aaa6_4805_91a4_d1867eb5d470
is: P55084
initial amount: NaN
is encoded by: hsa:3032
constant: false
type: Species
boundary condition: true
name: HADHB
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_69b7227a_0ca6_4e99_b98d_62b42b218a63
initial concentration: NaN
has only substance units: false
name: TYMS
is encoded by: hsa:7298
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: P04818

metaM fum m
name: Fumarate
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:29806
is: C00122
boundary condition: false
initial amount: NaN
is: HMDB00134
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false

metaM trp L c
is: HMDB00929
name: L-tryptophan
initial concentration: 1.0
constant: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:16828
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_661e44ff_218a_4286_aa2f_2f90bee84f5e
is encoded by: hsa:956
initial amount: NaN
boundary condition: true
constant: false
name: ENTPD3
initial concentration: NaN
is: O75355
is: SBO:0000252
has only substance units: false
type: Species

metaR r0170
type: Reaction
product: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110010#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: true

metaR EX 25hvitd3 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 25-Hydroxyvitamin D3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_09fcb517_012a_45e8_a99d_8d1a70184f83
initial amount: NaN
is encoded by: hsa:257202
name: GPX6
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P59796
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_5b25bd45_6979_4603_a981_a63b721b0b77
name: ACP1
is encoded by: hsa:52
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q59EH3
type: Species
boundary condition: true

metaR DM dttp m
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_0f356852_c9a5_444a_8747_730f56dcbaf1
is: B4DK61
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ACOX1
boundary condition: true
is encoded by: hsa:51
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_0a93c467_3f2c_4a4d_82fb_81add83d29d9
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:205
boundary condition: true
initial concentration: NaN
has only substance units: false
name: AK4

metaM leuktrA4 e
initial concentration: 1.0
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
constant: false
name: leukotriene A4(1-)
type: Species
boundary condition: false
is: CHEBI:57463
is: HMDB01337
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR CSND
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000176
name: Cytosine deaminase
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
reversible: false
reactant: MODEL1310110010#
fast: false
type: Reaction

metaM coa m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: Coenzyme A
initial amount: NaN
is: CHEBI:57287
type: Species
constant: false
is: C00010
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false

metaR GLCURtly
reactant: MODEL1310110010#
name: glucuronate transport into lysososme
reversible: true
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
is: SBO:0000185

metaR Htm
name: Uncoupling protein
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (9016.1) or (7352.2) or (7352.1) or (7351.1) or (9016.2) or (7350.1) or (9481.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
type: Reaction
product: MODEL1310110010#
is described by: ECO:0000269
reactant: MODEL1310110010#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110010#

metaR r2122
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
is: SBO:0000185
modifier: MODEL1310110010#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM adrnl c
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788
is: HMDB00068
type: Species
initial concentration: 1.0
is: CHEBI:33568
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: Adrenaline
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_3e2d6d39_3d0d_4de1_a29c_302cca2a2991
name: DCTD
is: P32321
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1635
is: SBO:0000252
type: Species
has only substance units: false

metaM nadh c
is: CHEBI:57945
initial concentration: 1.0
is: SBO:0000247
is: C00004
type: Species
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306

http://identifiers.org/biomodels.db/MODEL1310110010#_a21eefbb_c779_4117_aa1e_99969b6cf859
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: VNN3
is: SBO:0000252
constant: false
is encoded by: hsa:55350
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_e4e97f3b_f577_492b_9ca2_50ed93b4b422
is: P47895
type: Species
name: ALDH1A3
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:220
boundary condition: true

metaR RE1520M
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110010#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1520
kinetic law: MODEL1310110010#

metaR r0504
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.3.10
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
reversible: true
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2

http://identifiers.org/biomodels.db/MODEL1310110010#_84b0884e_dff8_4aa7_bf2f_014a090a8b1e
is: SBO:0000252
name: B3GNT6
type: Species
constant: false
boundary condition: true
is: A8K9Q8
is encoded by: hsa:192134
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_b10425ad_9fd2_4ba4_8864_25dd54b92f71
initial amount: NaN
is encoded by: hsa:5332
type: Species
name: PLCB4
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q15147

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR AG13T2g
fast: false
is: SBO:0000176
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
product: MODEL1310110010#

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_f85f2e93_adbc_4ea0_8fa1_b625a7684ede
is encoded by: hsa:51102
constant: false
has only substance units: false
boundary condition: true
type: Species
is: Q9BV79
name: MECR
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM odecoa c
name: Octadecenoyl-CoA (n-C18:1CoA)
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
is: HMDB01322
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:3793
boundary condition: false
has only substance units: false

metaM acnacngalgbside hs e
initial amount: NaN
is: C00036
type: Species
name: disialyl galactosylgloboside
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
constant: false
is: CHEBI:3338
is: HMDB00223

metaM lnlccoa r
boundary condition: false
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
has only substance units: false
name: linoleic coenzyme A
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_d78f8818_4608_450f_ad7c_58d080b78e58
boundary condition: true
type: Species
is: P48448
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:222
name: ALDH3B2

http://identifiers.org/biomodels.db/MODEL1310110010#_d27ebb85_780b_437c_be6f_1edae9e0a93a
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: CA6
type: Species
is encoded by: hsa:765
is: Q5FC00
initial amount: NaN
boundary condition: true

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM thf m
is: CHEBI:57453
boundary condition: false
is: HMDB01846
constant: false
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
has only substance units: false
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_63febab9_edb1_49a4_ad09_1b307a23211b
constant: false
has only substance units: false
is encoded by: hsa:48
boundary condition: true
type: Species
is: SBO:0000252
is: P21399
initial amount: NaN
name: ACO1
initial concentration: NaN

metaM atp n
is: HMDB00538
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57299
name: ATP(3-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
constant: false

metaR r0817
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110010#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
reactant: MODEL1310110010#
fast: false
type: Reaction
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:

metaR r0913
type: Reaction
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185

metaM retinal cis 9 r
is: CHEBI:17898
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: SBO:0000247
initial amount: NaN
name: all-trans-retinal
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01358
boundary condition: false

metaM prostgd2 r
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01403
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
type: Species
name: prostaglandin D2(1-)
constant: false
initial amount: NaN
initial concentration: 1.0

metaR r2121
reactant: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_dfd894a2_b567_49ea_ac81_1e99aa470239
is encoded by: hsa:47
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P53396
initial amount: NaN
name: ACLY
is: SBO:0000252

metaR GCALDD
name: Glycolaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_238bb6e8_521d_4560_9749_31c0dbd15472
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:10599
is: Q9Y6L6
name: SLCO1B1
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_f0faa8bb_799b_493c_b4c4_95e410b8d572
initial amount: NaN
boundary condition: true
name: _C7orf24_1_m
type: Species
is encoded by: hsa:C7orf24
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaM 4izp c
is: HMDB01014
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
constant: false
initial amount: NaN
type: Species
is: CHEBI:57255
name: 4-Imidazolone-5-propanoate

http://identifiers.org/biomodels.db/MODEL1310110010#_09aaf4a8_0921_4662_a8cf_be99fb4a8e17
initial concentration: NaN
name: _AI971036_1_m
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:AI971036
initial amount: NaN

metaM nad c
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57540
name: Nicotinamide adenine dinucleotide
initial amount: NaN
is: C00003
constant: false
boundary condition: false
has only substance units: false
type: Species

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR r2124
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_3da7dfd3_202d_4f40_be2b_8dbab5114b70
is: SBO:0000252
is encoded by: hsa:85365
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: ALG2

metaR r0818
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
name: Transport reaction

metaM CE4872 m
is: HMDB00127
initial amount: NaN
type: Species
constant: false
is: CHEBI:15748
has only substance units: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: SBO:0000247
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial concentration: 1.0
boundary condition: false

metaR r0502
product: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reactant: MODEL1310110010#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is version of: http://identifiers.org/ec-code/2.7.1.113
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110010#

metaR RE3301C
modifier: MODEL1310110010#
is: SBO:0000176
fast: false
name: RE3301
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM 3oddcoa m
is: SBO:0000247
initial amount: NaN
is: CHEBI:27868
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB03937
name: 3-Oxododecanoyl-CoA
boundary condition: false
type: Species
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263

metaM lcts e
name: Lactose
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
has only substance units: false
constant: false
is: C00243
is: HMDB00186
is: CHEBI:17716

http://identifiers.org/biomodels.db/MODEL1310110010#_fa51d2fc_e765_486b_ae3a_93f10409acf0
constant: false
initial amount: NaN
is: Q02338
has only substance units: false
boundary condition: true
name: BDH1
is encoded by: hsa:622
is: SBO:0000252
initial concentration: NaN
type: Species

metaM dump m
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:246422
type: Species
is: HMDB01409
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP(2-)
is: SBO:0000247

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_de6a995c_1ac1_4167_b95c_1ce2a76ccb6c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1718
boundary condition: true
is: Q15392
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: DHCR24

http://identifiers.org/biomodels.db/MODEL1310110010#_161c78b6_181a_49e5_a485_3b14c98bec2f
name: ELOVL5
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:60481
is: F6SH78
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM acnacngalgbside hs g
name: disialyl galactosylgloboside
constant: false
is: CHEBI:3338
boundary condition: false
is: HMDB00223
has only substance units: false
is: C00036
initial concentration: 1.0
type: Species
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: SBO:0000247
initial amount: NaN

metaR NCNt
modifier: MODEL1310110010#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110010#
name: Na+/Ca2+-NH4+ exchange
kinetic law: MODEL1310110010#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110010#_de4c5cbb_ac96_4306_b17a_dbbeb5441fee
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AU149534
type: Species
initial amount: NaN
boundary condition: true
name: _AU149534_1_e
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_23cdf482_dc0a_4a7a_92c9_d933684c7071
name: ST3GAL3
type: Species
is encoded by: hsa:6487
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR 5MTHFt
product: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
is: SBO:0000185
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_f5d120b1_2a1a_498a_9733_5e7c362d81f8
is encoded by: hsa:54344
is encoded by: hsa:8818
name: DPM3:DPM1:DPM2
type: Species
constant: false
has only substance units: false
has part: Q9P2X0
is: SBO:0000297
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR r2123
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM coa n
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
name: coenzyme A(4-)
has only substance units: false
is: SBO:0000247
is: HMDB01423

metaM xol7ah2 c
is: CHEBI:28047
constant: false
is: HMDB06893
type: Species
boundary condition: false
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha-diol
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: SBO:0000247

metaR r0819
is: SBO:0000185
reactant: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is described by: ECO:0000000
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#

metaR GUAt
product: MODEL1310110010#
modifier: MODEL1310110010#
name: Guanine transport
type: Reaction
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
kinetic law: MODEL1310110010#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000269

metaR r0915
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110010#_f179b721_ca5f_4625_9e6a_752445c7903d
constant: false
name: GALT
is: B4E097
is encoded by: hsa:2592
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaR FUCASEly
reversible: false
name: alpha-fucosidase, lysosomal
reactant: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
modifier: MODEL1310110010#
product: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.51
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_88115427_0117_4161_a03e_3f34f28c4c52
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI601100
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: _AI601100_1_m

metaR DNDPt23m
kinetic law: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110010#
fast: false
product: MODEL1310110010#
name: dTDP transport via dGTP antiport
reactant: MODEL1310110010#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_938e3a54_f1fc_4bcd_8f14_e6edde8c7649
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1375
is: Q53FV7
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: CPT1B
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_4ee86eae_a392_4fc3_bf99_7d93b6f57507
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AL038231
name: _AL038231_1_c
constant: false

metaM ksii core2 g
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)
is: HMDB01014
type: Species
has only substance units: false
is: CHEBI:57255
constant: false

metaM ksi deg27 l
name: keratan sulfate I, degradation product 27
initial amount: NaN
is: HMDB00143
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
has only substance units: false
type: Species
is: CHEBI:12936
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_3547bb95_0f13_4ed5_8b42_68e952ee2846
has only substance units: false
constant: false
is encoded by: hsa:89869
name: PLCZ1
is: SBO:0000252
boundary condition: true
type: Species
is: Q86YW0
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_e033a4b6_2053_424f_9c64_c8679db75554
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:22305
constant: false
has only substance units: false
initial concentration: NaN
name: _22305_2_c

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaM fe2 c
is: HMDB00692
name: Fe2+
has only substance units: false
constant: false
is: C00023
type: Species
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:29033

metaM stcoa m
has only substance units: false
type: Species
is: HMDB01114
is: C00412
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
name: Stearoyl-CoA (n-C18:0CoA)
is: CHEBI:57394
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR DURAD2
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.1.2
name: dihydrothymin dehydrogenase (NADP)
product: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109

http://identifiers.org/biomodels.db/MODEL1310110010#_ebd05ab2_97e0_4038_808c_373cf565a882
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:7352
is: P55916
boundary condition: true
initial concentration: NaN
type: Species
name: UCP3

metaR ACACT6p
reversible: false
type: Reaction
reactant: MODEL1310110010#
name: acetyl-CoA C-acetyltransferase (dodecanoyl), peroxisomal
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM dutp m
type: Species
is: CHEBI:17625
initial amount: NaN
initial concentration: 1.0
name: dUTP
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_f8260c13_3a95_4b9b_8a2e_b88e74fe143b
is encoded by: hsa:8706
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: B3GALNT1
constant: false
initial concentration: NaN
is: Q8TDY1

http://identifiers.org/biomodels.db/MODEL1310110010#_18193c38_f4d6_4bd6_8fb3_c79b447543b6
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: GGT7
boundary condition: true
is encoded by: hsa:2686
is: A0PJJ9
initial concentration: NaN
constant: false
type: Species

metaM fe2 e
type: Species
initial amount: NaN
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29033
boundary condition: false
name: Fe2+
is: HMDB00692
is: C00023
constant: false
has only substance units: false

metaR GLNyLATthc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM pep m
is: C00074
boundary condition: false
is: CHEBI:18021
constant: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00263
initial amount: NaN
initial concentration: 1.0
name: Phosphoenolpyruvate

metaM e4hglu m
constant: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
has only substance units: false
is: CHEBI:6331
boundary condition: false
type: Species
is: HMDB02273
initial concentration: 1.0
name: erythro-4-hydroxy-L-glutamate(1-)
initial amount: NaN
is: SBO:0000247

metaR DOPABMO
fast: false
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.14.17.1
is described by: ECO:0000269
modifier: MODEL1310110010#
reversible: false
type: Reaction
kinetic law: MODEL1310110010#
name: dopamine beta-monooxygenase
is: SBO:0000176
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB

metaM stcoa x
is: C00412
is: HMDB01114
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
constant: false
is: SBO:0000247
is: CHEBI:57394
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: Stearoyl-CoA (n-C18:0CoA)
initial amount: NaN

metaM k c
is: HMDB00586
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
name: potassium
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
constant: false
initial amount: NaN
is: CHEBI:29103
is: C00238
boundary condition: false

metaR PYRt2m
name: pyruvate mitochondrial transport via proton symport
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
reversible: true
fast: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
type: Reaction
product: MODEL1310110010#
is described by: ECO:0000000

metaR r0245
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is: SBO:0000176
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR r2113
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR HACD9m
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
modifier: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110010#_fc5c5fd5_73ad_4ec4_b83d_9e3a3b7f17e4
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6584
initial amount: NaN
name: SLC22A5
is: O76082
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_38b00013_929b_4038_9000_6f2df0a8ef97
is: B4DIA3
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC6A8
is encoded by: hsa:6535
constant: false
type: Species
is: SBO:0000252

metaR Htr
reactant: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
name: H transporter, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_33ec275b_1004_424f_9ecf_e4a7e84cc9e2
has only substance units: false
initial concentration: NaN
name: _AI090874_1_c
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:AI090874

metaM ribflv e
is: C00255
has only substance units: false
constant: false
is: HMDB00244
name: Riboflavin
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false
initial amount: NaN
is: CHEBI:3554
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR 3MLDAt
reversible: true
kinetic law: MODEL1310110010#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
product: MODEL1310110010#
name: 3MLDA extracellular transport via diffusion
reactant: MODEL1310110010#
is described by: ECO:0000000

metaR r2114
kinetic law: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR PSFLIPm
name: phosphatidylserine flippase
product: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.6.3.1
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ

http://identifiers.org/biomodels.db/MODEL1310110010#_39fc7ef3_47a1_4021_96cc_b7c0caa9ce11
is: SBO:0000252
boundary condition: true
name: _AI697028_1_m
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI697028

metaM C05965 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
name: 12(S)-HPETE(1-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:57444
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB04243
has only substance units: false
constant: false

metaM HC00319 c
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
type: Species
name: Malonate
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR GASNASE2ly
is: SBO:0000176
name: glycosylasparaginase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.26
product: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_3553736d_1f9a_476a_bade_bdf9f942f57b
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:BF195998
is: SBO:0000252
initial amount: NaN
name: _BF195998_1_x

metaM ksi deg30 l
boundary condition: false
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
initial concentration: 1.0
is: HMDB00143
name: keratan sulfate I, degradation product 30
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:12936

metaM mhista c
is: SBO:0000247
is: CHEBI:58600
constant: false
has only substance units: false
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
type: Species
boundary condition: false
name: N(tele)-methylhistaminium
initial concentration: 1.0
initial amount: NaN
is: HMDB00898

metaM acald c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00990
name: acetaldehyde
is: CHEBI:15343
type: Species
has only substance units: false
constant: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaM dhap x
is: HMDB01473
is: http://identifiers.org/pubchem.compound/3411
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: Dihydroxyacetone phosphate
is: C00111
is: CHEBI:57642

metaM ksii core2 deg6 l
has only substance units: false
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 6
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C44H72N4O33SX CHARGE: -1

metaR XYLTt
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
name: Xylitol transport via passive diffusion

metaR r2115
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110010#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaM ksii core4 pre2 g
name: keratan sulfate II boisynthesis, precursor 2
notes: FORMULA: C47H76N4O33X CHARGE: -1
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00130
is: HMDB00175
type: Species

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR CITt4 4
kinetic law: MODEL1310110010#
name: citrate transport via sodium symport
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
reversible: true
product: MODEL1310110010#
modifier: MODEL1310110010#
type: Reaction
is: SBO:0000185
is described by: ECO:0000006

metaR r0166
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110010#
is: SBO:0000176

metaR RE0577C
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
fast: false
reversible: true
modifier: MODEL1310110010#
is described by: ECO:0000000
name: RE0577
product: MODEL1310110010#

metaR GAL3ST12
is version of: http://identifiers.org/ec-code/2.8.2.11
name: Galactosylceramide sulfotransferase
reversible: false
modifier: MODEL1310110010#
fast: false
is described by: ECO:0000269
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
kinetic law: MODEL1310110010#

metaR S2L2FN2M2MASNtly
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is: SBO:0000185
reversible: false
fast: false
name: s2l2fn2m2masn transport, extracellular to lysosome

metaM adp x
has only substance units: false
name: ADP(3-)
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01341
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216

metaR SO4t4 2
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
product: MODEL1310110010#
name: sulfate transport via sodium symport
is described by: ECO:0000269

metaM gluside hs g
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: CHEBI:18368
constant: false
boundary condition: false
name: D-glucosyl-N-acylsphingosine
type: Species

metaM coa r
is: HMDB01423
is: CHEBI:57287
initial amount: NaN
name: Coenzyme A
initial concentration: 1.0
boundary condition: false
is: C00010
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
type: Species

metaM k e
is: C00238
is: CHEBI:29103
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00586
boundary condition: false
name: potassium
type: Species
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
has only substance units: false
constant: false

metaM hmgcoa x
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
is: HMDB01375
constant: false
is: SBO:0000247
type: Species
is: CHEBI:15467

http://identifiers.org/biomodels.db/MODEL1310110010#_1eb11306_4a87_48d3_b9b2_188b0edca4af
is: Q86YN1
name: DOLPP1
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:57171
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ec73f38c_1f59_4130_a0dc_e18cf1556df3
initial concentration: NaN
type: Species
is: P61457
is encoded by: hsa:5092
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: PCBD1

metaR r2116
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110010#
is described by: ECO:0000000
reversible: true

metaM ribflv c
type: Species
is: SBO:0000247
name: Riboflavin
is: C00255
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false
constant: false
is: HMDB00244
initial amount: NaN
is: CHEBI:3554
initial concentration: 1.0
has only substance units: false

metaR PHEACGLNt
reactant: MODEL1310110010#
name: PHEACGLN extracellular transport via diffusion
fast: false
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM HC01602 c
constant: false
is: SBO:0000247
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
type: Species
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR GAL3ST11
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
fast: false
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.8.2.11
is described by: ECO:0000000
name: Galactosylceramide sulfotransferase
reversible: false

metaM CE2433 m
is: http://identifiers.org/pubchem.compound/5041
constant: false
initial amount: NaN
is: C01936
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433

metaM csn e
type: Species
boundary condition: false
initial concentration: 1.0
name: cytosine
is: HMDB00630
is: CHEBI:16040
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
constant: false
is: SBO:0000247

metaM dopa e
is: CHEBI:59905
boundary condition: false
type: Species
initial concentration: 1.0
name: dopaminium(1+)
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_b578b0b2_180f_4b40_886c_3dd39f83a42d
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC3A2
is encoded by: hsa:6520
is: P08195
constant: false
is: SBO:0000252

metaR r0242
is: SBO:0000176
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is described by: ECO:0000000
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
reversible: true
reactant: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction

metaR HACD1m
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
kinetic law: MODEL1310110010#
is described by: ECO:0000134
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110010#
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_494faeb9_a263_485f_b992_6e96ea1de157
name: SLC26A6
type: Species
is: Q548A7
constant: false
is encoded by: hsa:65010
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR r1544
reversible: true
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000

metaR FACOAL246 1
modifier: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
is: SBO:0000176
product: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110010#
fast: false
reversible: true

metaR RE2349C
is: SBO:0000176
name: RE2349
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110010#
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C

metaM ksi deg5 l
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: HMDB00143
boundary condition: false
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 5
is: CHEBI:12936
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247

metaM pro D e
boundary condition: false
name: D-proline
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: CHEBI:16313
constant: false
initial concentration: 1.0
is: HMDB03411
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_aa32b848_577c_4c29_9185_741ee7951734
name: INPP5J
has only substance units: false
is encoded by: hsa:27124
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: Q15735
boundary condition: true
initial concentration: NaN

metaR GTHPm
is version of: http://identifiers.org/ec-code/1.11.1.12
reversible: true
is described by: ECO:0000269
type: Reaction
name: glutathione peroxidase, mitochondria
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is: SBO:0000176
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.11.1.15
modifier: MODEL1310110010#

metaR r2117
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR S2L2N2M2MASNtly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110010#
type: Reaction
name: s2l2n2m2masn transport, extracellular to lysosome
kinetic law: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: false

metaM adp r
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
has only substance units: false
is: HMDB01341
boundary condition: false
is: SBO:0000247
constant: false
name: ADP(3-)
type: Species
is: CHEBI:456216

metaR S6T10g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reversible: false
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM aacoa x
initial amount: NaN
is: SBO:0000247
name: acetoacetyl-CoA(4-)
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_6bc0710a_8c96_45de_8feb_0b15a34d125e
constant: false
is: SBO:0000252
is encoded by: hsa:5625
name: PRODH
is: O43272
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_1fbfea98_6d00_4e5d_b316_2e32c8bb4710
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR r1607
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true

metaR r0821
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
reactant: MODEL1310110010#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000

metaM HC01842 c
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
name: Phosphodimethylethanolamine
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:31997
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR FAEL204
modifier: MODEL1310110010#
is: SBO:0000176
name: fatty-acyl-CoA elongation (n-C20:4CoA)
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_f4ad8aad_b573_4102_a1cc_6e4d53b35e53
is: B4DK61
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: ACOX1
is encoded by: hsa:51
boundary condition: true
initial concentration: NaN

metaM ura e
is: HMDB00300
constant: false
name: uracil
initial amount: NaN
is: CHEBI:17568
has only substance units: false
type: Species
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM csn c
constant: false
name: cytosine
is: HMDB00630
is: CHEBI:16040
type: Species
has only substance units: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR ENGASE2ly
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
kinetic law: MODEL1310110010#
name: endo-beta-N-acetylglucosaminidase, lysosomal
product: MODEL1310110010#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_55e620e7_7aa8_44b7_97a2_0b36e983f48a
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM lanost r
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01251
constant: false
initial concentration: 1.0
name: lanosterol
is: CHEBI:16521
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
boundary condition: false
is: SBO:0000247

metaR r2118
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: true
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110010#

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR 3HKYNAKGAT
kinetic law: MODEL1310110010#
reversible: false
product: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
is version of: http://identifiers.org/ec-code/2.6.1.7
fast: false
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110010#

metaR GluForTx
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
product: MODEL1310110010#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.5
modifier: MODEL1310110010#
is: SBO:0000176
name: Glutamate formimidoyltransferase
type: Reaction

metaR HDCAtr
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110010#
name: fatty acid transport via diffusion

metaR EX retinol 9 cis LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-cis-retinol exchange
type: Reaction

metaM acglcgalgluside hs g
is: CHEBI:17103
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
has only substance units: false
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
initial concentration: 1.0
constant: false

metaR r1546
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110010#
fast: false
reversible: true
is described by: ECO:0000000

metaR DNDPt16m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110010#
name: dUDP transport via dADP antiport
product: MODEL1310110010#
is described by: ECO:0000269
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_45793a8d_c3c8_49bf_bbb8_5b43c450d380
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: ENPP3
type: Species
is: Q308M7
is encoded by: hsa:5169
has only substance units: false
is: SBO:0000252

metaM 4nph c
constant: false
initial amount: NaN
name: 4-nitrophenolate
is: CHEBI:57917
type: Species
initial concentration: 1.0
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR HEXCt
name: fatty acid transport via diffusion
is: SBO:0000185
product: MODEL1310110010#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110010#

metaM ha l
name: hyaluronan
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:16336

metaR NACHEX22ly
reactant: MODEL1310110010#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaR 5ADTSTSTERONEte
is: SBO:0000185
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
name: 5 alpha dihydrotesterone transport
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_5969b77a_b8f8_4e8f_b5c1_ab5d4616e17e
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: CHKB
is: Q9Y259
is encoded by: hsa:1120
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM paps c
has only substance units: false
initial concentration: 1.0
constant: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:58339
is: SBO:0000247
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: HMDB01134

metaR r1606
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110010#
fast: false

metaM paps g
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial amount: NaN
is: CHEBI:58339
is: SBO:0000247
is: HMDB01134
constant: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate

metaR GALASE1ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
type: Reaction
product: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
fast: false
reactant: MODEL1310110010#

metaR GALASE9ly
kinetic law: MODEL1310110010#
is: SBO:0000176
name: beta-galactosidase, lysosomal
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
reversible: false
type: Reaction

metaM 56dthm c
is: HMDB00079
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
name: 5,6-dihydrothymine
type: Species
is: CHEBI:27468
has only substance units: false

metaR FAEL205
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110010#
name: fatty-acyl-CoA elongation (n-C20:5CoA)
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ

metaR DCYTt
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
reversible: true
type: Reaction
name: deoxycytidine transport via diffusion
product: MODEL1310110010#

metaM glu L e
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00148
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247
constant: false
initial concentration: 1.0
name: L-glutamate(1-)
is: CHEBI:29985

http://identifiers.org/biomodels.db/MODEL1310110010#_e03517d4_4bf2_40e4_824a_a40c055bc8e3
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PLCE1
is encoded by: hsa:51196
initial amount: NaN
is: Q9P212
is: SBO:0000252
constant: false
type: Species

metaM chito2pdol U c
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:12427
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM pro D c
is: HMDB03411
boundary condition: false
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:16313
initial concentration: 1.0
has only substance units: false
constant: false

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_6ad54e1f_f64f_4500_acc2_bbd1b7928b41
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:7352
has only substance units: false
name: UCP3
constant: false
initial amount: NaN
initial concentration: NaN

metaR r2119
product: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110010#
fast: false

metaM hdca r
is: HMDB00220
is: CHEBI:7896
type: Species
initial amount: NaN
is: C00249
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
name: Hexadecanoate (n-C16:0)
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR VALTAm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.6.1.42
name: valine transaminase, mitochondiral
reversible: true
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_4d89f718_10d2_472b_805e_17deae06bdee
is: SBO:0000252
name: SLC26A4
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5172
constant: false
initial amount: NaN
type: Species
is: O43511

http://identifiers.org/biomodels.db/MODEL1310110010#_9010f7ac_d6dd_4fd9_afff_3a0c2ebd39fa
is: SBO:0000252
type: Species
is encoded by: hsa:T83654
has only substance units: false
boundary condition: true
initial amount: NaN
name: _T83654_1_e
initial concentration: NaN
constant: false

metaR r1547
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
fast: false

metaM fucacgalfucgalacglcgalgluside hs g
initial amount: NaN
constant: false
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
is: C00445
is: HMDB01354
is: CHEBI:57455
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM dump c
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
initial concentration: 1.0
is: C00365
is: HMDB01409
name: dUMP
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:246422
type: Species
is: SBO:0000247

metaR ARACHDt2
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110010#
name: fatty acid transport via diffusion
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110010#

metaR r1609
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110010#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110010#

metaM ksi pre11 g
type: Species
name: keratan sulfate I biosynthesis, precursor 11
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:28067
initial concentration: 1.0
boundary condition: false
constant: false

metaM zymst r
name: zymosterol
is: CHEBI:18252
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB06271
constant: false

metaR F6Tg
modifier: MODEL1310110010#
reversible: false
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.68
name: glycoprotein 6-alpha-L-fucosyltransferase
type: Reaction

metaM ura c
initial concentration: 1.0
is: C00106
is: CHEBI:17568
name: Uracil
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
is: SBO:0000247

metaM ksi deg41 l
type: Species
notes: FORMULA: C34H58N2O26 CHARGE: 0
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:12936
boundary condition: false
name: keratan sulfate I, degradation product 41
is: HMDB00143

metaR NDPK9n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is: SBO:0000176
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
type: Reaction
modifier: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false

metaM HC02180 c
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:28728

metaR RE3241R
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: RE3241
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110010#
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_d0f2b946_0db8_4df2_8ff3_9ff564a21809
name: AMT
initial amount: NaN
is: P48728
is: SBO:0000252
type: Species
is encoded by: hsa:275
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_563c56c8_65d8_469c_ac82_4ee6e86ff23e
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6531
initial amount: NaN
is: Q01959
name: SLC6A3
initial concentration: NaN

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR MECOALm
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110010#
reversible: true
fast: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000212
is: SBO:0000176

metaM Rtotal2 e
type: Species
is: HMDB00244
initial amount: NaN
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: C00255
initial concentration: 1.0
boundary condition: false
is: CHEBI:3554
is: SBO:0000247
constant: false
has only substance units: false
name: R total 2 position

metaM ksi pre19 g
name: keratan sulfate I biosynthesis, precursor 19
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: C00130
is: HMDB00175
type: Species
is: CHEBI:58053
initial concentration: 1.0

metaR ACACT10m
reactant: MODEL1310110010#
reversible: true
product: MODEL1310110010#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
type: Reaction
modifier: MODEL1310110010#
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9

metaR ADPtx
reversible: true
kinetic law: MODEL1310110010#
is: SBO:0000185
name: ADP transporter, peroxisomal
product: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

metaM ksii core4 deg1 l
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57737
is: SBO:0000247
initial amount: NaN
is: HMDB00868
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 1
notes: FORMULA: C78H126N6O64S3X CHARGE: -3

metaM coa x
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
is: CHEBI:57287
name: Coenzyme A
is: HMDB01423
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_88736b25_42b0_4d1c_ad0b_f9fd31e6fcb3
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: GMPS
initial amount: NaN
is encoded by: hsa:8833
initial concentration: NaN
constant: false
is: P49915

metaR GLCMter
product: MODEL1310110010#
name: glucose transport via membrane vesicle
is: SBO:0000185
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD

metaR r1548
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
reversible: true

metaR CORE7GTg
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction
name: Core 7 alpha-GalNAc-transferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false

metaM m4mpdol U r
type: Species
is: CHEBI:37633
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR r1608
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
product: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
fast: false

metaR r0822
modifier: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110010#
reversible: true
type: Reaction

metaR r1966
reversible: false
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaM acald e
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
has only substance units: false
name: acetaldehyde
is: CHEBI:15343
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_d923c2f8_775c_4add_b811_d7557fa9cc33
has only substance units: false
is: SBO:0000252
is encoded by: hsa:56052
initial concentration: NaN
type: Species
name: ALG1
constant: false
initial amount: NaN
is: Q9BT22
boundary condition: true

metaR FAS180COA
name: fatty-acyl-CoA synthase (n-C18:0CoA)
is: SBO:0000176
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is described by: ECO:0000269
fast: false
modifier: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR r0652
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110010#
fast: false

metaR NACHEX25ly
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR SACCD4m
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
is version of: http://identifiers.org/ec-code/1.5.1.8
is: SBO:0000176
type: Reaction
reactant: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110010#_4e458ca3_fbed_46ee_9a10_c15186faec64
has only substance units: false
constant: false
boundary condition: true
name: IVD
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3712
type: Species
is: B3KVI7

metaR r0398
notes: GENE_ASSOCIATION: (5160.1) or (5161.1) or (5162.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.5.1.34 Confidence Level: 0 AUTHORS: PMID:7317032 NOTES:
is: SBO:0000176
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.4.1
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110010#
reversible: true
modifier: MODEL1310110010#
reactant: MODEL1310110010#
name: NADPH:6,7-dihydropteridine oxidoreductase Folate biosynthesis EC:1.5.1.34

metaR MG2er
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000176
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reversible: false
is described by: ECO:0000000
product: MODEL1310110010#

metaR r1603
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false

metaM hdca l
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00220
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: CHEBI:7896
boundary condition: false
is: SBO:0000247
name: palmitate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_b0fd49e7_ba6f_4117_b524_b24922f83b96
is encoded by: hsa:79611
initial amount: NaN
type: Species
is: Q9H6R3
constant: false
name: ACSS3
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR ETOHt
name: ethanol reversible transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110010#
fast: false
reversible: true
kinetic law: MODEL1310110010#
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_24671eb4_aca0_4c04_ae99_c44482000523
name: NOS1
initial concentration: NaN
is encoded by: hsa:4842
is: SBO:0000252
has only substance units: false
boundary condition: true
is: B4DG68
constant: false
type: Species
initial amount: NaN

metaM HC01415 m
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:27537
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: (2E)-Octenoyl-CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_1c45dd7e_e0a0_48d7_912c_15b1f545e083
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:123041
name: SLC24A4
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_9bdbb105_0ccb_4604_aa10_f5c1c401f4c6
type: Species
is encoded by: hsa:23517
constant: false
initial concentration: NaN
initial amount: NaN
is: Q3MHC9
name: SKIV2L2
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_4f718038_055c_4048_9732_f0c9b4ea0b5c
constant: false
boundary condition: true
is encoded by: hsa:43
initial amount: NaN
is: P22303
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: ACHE

metaM glu L c
has only substance units: false
is: SBO:0000247
is: HMDB00148
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: L-glutamate(1-)
is: CHEBI:29985
initial amount: NaN

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM dgsn c
name: Deoxyguanosine
boundary condition: false
has only substance units: false
is: CHEBI:17172
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
type: Species
is: HMDB00085
is: C00330

http://identifiers.org/biomodels.db/MODEL1310110010#_18fa94a6_ea28_4dce_8c70_b2cce4053717
boundary condition: true
is: P33908
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4121
name: MAN1A1
initial concentration: NaN

metaM prostgd2 e
initial amount: NaN
type: Species
constant: false
is: HMDB01403
boundary condition: false
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
name: prostaglandin D2(1-)
is: SBO:0000247
initial concentration: 1.0

metaM HC00319 m
name: Malonate
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r0653
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110010#
reversible: false
product: MODEL1310110010#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
type: Reaction
kinetic law: MODEL1310110010#

metaR G14T2g
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
product: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is described by: ECO:0000000
modifier: MODEL1310110010#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110010#_4c66e08d_d1ae_42e8_b4bd_5d182c1cd54d
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:291
type: Species
initial concentration: NaN
name: SLC25A4
is: P12235
boundary condition: true

metaR r1602
kinetic law: MODEL1310110010#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110010#
reversible: true
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_10ba65aa_3472_48cd_a5eb_e8edd0570d0e
is encoded by: hsa:374907
is: SBO:0000252
constant: false
name: B3GNT8
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaM gluala e
is: HMDB06248
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6503
initial amount: NaN
is: C03740
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
type: Species
has only substance units: false
boundary condition: false
name: 5-L-Glutamyl-L-alanine
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_33ddc5a0_4808_4e7a_8ce2_128205bcbd13
boundary condition: true
is: SBO:0000252
is: Q02127
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: DHODH
is encoded by: hsa:1723

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_66937bfc_b439_4964_bac3_4e8009a1f252
is encoded by: hsa:2639
boundary condition: true
is: Q92947
initial amount: NaN
name: GCDH
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaM 3oddcoa x
constant: false
has only substance units: false
is: HMDB03937
name: 3-Oxododecanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:27868
initial amount: NaN

metaM HC02180 e
type: Species
initial concentration: 1.0
boundary condition: false
name: thromboxane-b2
has only substance units: false
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: SBO:0000247
initial amount: NaN
is: CHEBI:28728

metaM mmcoa R m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: SBO:0000247
is: HMDB01269
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: (R)-methylmalonyl-CoA(5-)
is: CHEBI:57326
constant: false
type: Species
boundary condition: false

metaR r2338
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reactant: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
fast: false

metaM 2mb2coa m
has only substance units: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57337
constant: false
type: Species
initial amount: NaN
boundary condition: false
name: 2-methylcrotonoyl-CoA(4-)
is: HMDB02054

http://identifiers.org/biomodels.db/MODEL1310110010#_b7b12f69_2898_4abb_b86c_f8243384cdb4
initial concentration: NaN
is: P20933
name: AGA
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:175
initial amount: NaN
constant: false

metaM dctp c
name: dCTP
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16311
constant: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: HMDB00998
has only substance units: false
type: Species
is: C00458
boundary condition: false
is: SBO:0000247

metaR CYTK2
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: cytidylate kinase (dCMP)
fast: false
type: Reaction
is described by: ECO:0000269
reversible: true
is: SBO:0000176

metaR r1605
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR CO2tm
name: CO2 transport (diffusion), mitochondrial
fast: false
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF

metaR DIGALSIDEtg
reversible: true
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110010#
name: digalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000

metaR ALOX5
type: Reaction
modifier: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/1.13.11.34
name: Arachidonate 5-lipoxygenase
kinetic law: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
fast: false

metaR BTNt2
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
reversible: true
modifier: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
name: Biotin reversible transport via proton symport
reactant: MODEL1310110010#
fast: false

metaR r1259
product: MODEL1310110010#
is: SBO:0000176
fast: false
name: EC:6.2.1.3
reactant: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110010#
reversible: false

metaR r1969
product: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#

metaR r0714
product: MODEL1310110010#
fast: false
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110010#_d89f4f05_ce2d_4c79_a523_f7b78ed155f8
is encoded by: hsa:5730
name: PTGDS
is: P41222
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_c1f60ddc_3d79_4700_a62f_87039da497a3
initial concentration: NaN
has only substance units: false
name: SLC35D1
is: SBO:0000252
is: Q9NTN3
constant: false
initial amount: NaN
is encoded by: hsa:23169
boundary condition: true
type: Species

metaR C204CRNt
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
reversible: false
name: arachidonic acid transport into the mitochondria
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_21f75461_8299_4dc4_9725_572d186d3d05
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: LDHD
is encoded by: hsa:197257
is: Q86WU2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_b686134e_e4fd_4997_acdc_841ceb6db8cc
is: Q9NWU1
is encoded by: hsa:54995
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: OXSM
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_7f1dd86c_c1ef_4a8a_b461_901aada195cd
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: ATP8A1
initial amount: NaN
is encoded by: hsa:10396
has only substance units: false
is: Q9Y2Q0
constant: false

metaR r2335
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
is: SBO:0000185

metaM retinol cis 13 c
is: CHEBI:45479
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13-
name: 13-cis-retinol
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB06217
type: Species
initial concentration: 1.0

metaR r0791
type: Reaction
fast: false
product: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR r0650
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.36
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_8fe1b323_898b_49f6_a9ef_f0c3fb47ea2e
is: E9KL44
constant: false
name: HADHA
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3030
has only substance units: false

metaR C4STMO2r
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
reversible: false
is: SBO:0000176
type: Reaction
fast: false
name: C-4 methyl sterol oxidase
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.14.13.72
is version of: http://identifiers.org/ec-code/1.1.1.170
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#

metaM retinal cis 9 c
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01358
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: CHEBI:17898
name: all-trans-retinal

metaR HMGCOASi
reversible: false
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
fast: false
name: Hydroxymethylglutaryl CoA synthase (ir)
is version of: http://identifiers.org/ec-code/2.3.3.10
kinetic law: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
product: MODEL1310110010#
is: SBO:0000176

metaR CYTK1
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000176
name: cytidylate kinase (CMP)
modifier: MODEL1310110010#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_42962851_1d77_4b79_a98c_ac0a1a6ca5cd
is: P30084
initial amount: NaN
is encoded by: hsa:1892
initial concentration: NaN
name: ECHS1
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaM cdp n
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
boundary condition: false
is: HMDB01546
type: Species
name: CDP(3-)

metaM tettet6coa c
initial concentration: 1.0
constant: false
has only substance units: false
is: C16171
is: http://identifiers.org/pubchem.compound/47205481
is: SBO:0000247
type: Species
is: HMDB06516
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
boundary condition: false
initial amount: NaN
name: tetracosatetraenoyl coenzyme A

metaR r0651
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
fast: false
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: CHEBI:57917
constant: false
initial amount: NaN
name: 4-nitrophenolate
is: SBO:0000247
is: HMDB01232
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaM q10 m
type: Species
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
name: ubiquinone-10
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01072

metaR LEUTA
type: Reaction
name: leucine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#

metaR r1604
type: Reaction
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110010#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110010#

metaR r1818
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
name: Y+LAT2 Utilized transport
product: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM sphs1p c
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00277
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_9bbaca2e_3744_4a6d_b65c_8be8c8dc5a97
is: SBO:0000252
type: Species
has only substance units: false
is: Q5MY95
name: ENTPD8
initial amount: NaN
is encoded by: hsa:377841
constant: false
initial concentration: NaN
boundary condition: true

metaR r0792
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110010#

metaM odecoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: SBO:0000247
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
is: CHEBI:57387
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false

metaM leuktrB4 e
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
constant: false
name: leukotriene B4(1-)
initial concentration: 1.0
is: HMDB01085

http://identifiers.org/biomodels.db/MODEL1310110010#_fe9a1b5b_e049_4066_a311_7a4bdd3f6f5c
is: SBO:0000252
is encoded by: hsa:277
initial concentration: NaN
boundary condition: true
name: AMY1B
initial amount: NaN
is: P04745
has only substance units: false
constant: false
type: Species

metaR Htx
kinetic law: MODEL1310110010#
reversible: true
product: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
name: H transporter, peroxisome

metaR r2099
modifier: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0716
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaM itp c
constant: false
name: ITP(3-)
is: CHEBI:57614
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00189
type: Species

metaR r1257
fast: false
name: EC:6.2.1.3
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110010#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_904f57da_fc6b_4de1_b342_8e232c950d1c
type: Species
initial amount: NaN
is encoded by: hsa:AI972237
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: _AI972237_1_c
is: SBO:0000252

metaM 4abutn c
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00555
has only substance units: false
is: CHEBI:58264
constant: false
is: HMDB01080
name: 4-Aminobutanal
is: SBO:0000247
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

http://identifiers.org/biomodels.db/MODEL1310110010#_1a5086f0_8ba0_4110_9c88_b8ce82947854
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: PANK2
is encoded by: hsa:80025
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaR r0797
reactant: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: glycine N-choloyltransferase EC:2.3.1.65
product: MODEL1310110010#

metaR r2333
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#
reversible: true
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_e4e6a826_0ea0_424c_9c5d_045d7fdeff1f
name: SLC38A1
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9H2H9
has only substance units: false
is encoded by: hsa:81539

http://identifiers.org/biomodels.db/MODEL1310110010#_8657cdbe_827d_4e8d_bd5a_6c1a9c4df694
is: O43505
boundary condition: true
has only substance units: false
initial concentration: NaN
name: B3GNT1
initial amount: NaN
type: Species
is encoded by: hsa:11041
constant: false
is: SBO:0000252

metaM tethex3coa c
is: SBO:0000247
initial amount: NaN
is: HMDB06243
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205478
constant: false
boundary condition: false
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
is: C16168
initial concentration: 1.0
name: tetracosahexaenoyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110010#_a4258e0e_9370_421c_bfab_4f2b3df0db57
initial amount: NaN
is encoded by: hsa:3417
name: IDH1
constant: false
type: Species
initial concentration: NaN
is: O75874
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR G3PD1
reactant: MODEL1310110010#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is version of: http://identifiers.org/ec-code/1.1.1.8
reversible: true
is: SBO:0000176
product: MODEL1310110010#
name: glycerol-3-phosphate dehydrogenase (NAD)
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_833d9c39_a6cc_42f5_a97d_f0e8a479d169
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9GZX3
name: CHST6
type: Species
boundary condition: true
constant: false
is encoded by: hsa:4166

metaR SRTNt6 2 r
type: Reaction
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
fast: false
product: MODEL1310110010#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_4a2f2701_7edb_4143_bbfb_7ed383630e2e
name: HSD3B2
is: P26439
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3284

metaR r0715
type: Reaction
is described by: ECO:0000000
product: MODEL1310110010#
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/6.3.2.5
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_3b1aa2b5_bc3c_4e05_89c8_5985b1c9c80a
initial concentration: NaN
type: Species
is encoded by: hsa:47
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
name: ACLY
is: SBO:0000252

metaR r2098
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#

metaR RETH1e
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
kinetic law: MODEL1310110010#
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110010#
name: retinyl ester hydrolase (9-cis), extracellular
reactant: MODEL1310110010#

metaR r1812
type: Reaction
name: Y+LAT2 Utilized transport
reversible: false
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#

metaM HC01522 c
name: Gentisate aldehyde
is: SBO:0000247
is: CHEBI:28508
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
initial amount: NaN

metaR RE3273C
name: RE3273
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
type: Reaction
reactant: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reversible: true
fast: false
is: SBO:0000176

metaR AMACR2p
kinetic law: MODEL1310110010#
reversible: false
fast: false
reactant: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
is described by: ECO:0000304
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/5.1.99.4
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
type: Reaction
name: alpha-methylacyl-CoA racemase (reductase)

metaR METS
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
name: methionine synthase
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.1.1.13
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110010#
type: Reaction

metaR CYTK9n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is: SBO:0000176
fast: false
name: cytidylate kinase (CMP,dCTP),nuclear
type: Reaction
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#

metaR P4507A1r
kinetic law: MODEL1310110010#
name: cytochrome P450, family 7, subfamily A, polypeptide 1
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.14.13.17
is: SBO:0000176
reversible: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110010#

metaM leuktrB4 c
is: HMDB01085
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
type: Species
boundary condition: false
constant: false
is: CHEBI:57461
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: leukotriene B4(1-)

http://identifiers.org/biomodels.db/MODEL1310110010#_73973369_1a75_45af_b693_b5944821e41b
initial concentration: NaN
boundary condition: true
has part: E9KL44
initial amount: NaN
type: Species
is encoded by: hsa:3030
is: SBO:0000297
is encoded by: hsa:3032
name: HADHA:HADHB
constant: false
has only substance units: false
has part: P55084

metaR r2334
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
reversible: true
is: SBO:0000185

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM hmgcoa m
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
name: Hydroxymethylglutaryl-CoA
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:15467
initial concentration: 1.0
is: SBO:0000247
is: HMDB01375

http://identifiers.org/biomodels.db/MODEL1310110010#_b7a6f012_7fe6_491f_9e15_3da1be051305
type: Species
is: Q12882
is encoded by: hsa:1806
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: DPYD
boundary condition: true
has only substance units: false

metaM sphs1p e
is: SBO:0000247
is: CHEBI:60119
boundary condition: false
name: sphingosine 1-phosphate(1-)
is: HMDB00277
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM dopa c
initial concentration: 1.0
name: dopaminium(1+)
is: CHEBI:59905
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073
type: Species
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_e250b599_bc18_4478_8586_e47c5747c184
is encoded by: hsa:8659
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ALDH4A1
is: P30038

metaR LPS2
name: lipase
reactant: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.1.34
modifier: MODEL1310110010#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_df95bd2b_411b_4d2f_8b72_9bb8f319fcc7
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:7054
is: SBO:0000252
boundary condition: true
is: P07101
name: TH
initial concentration: NaN
has only substance units: false

metaR ICDHy
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110010#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
name: isocitrate dehydrogenase (NADP)
reactant: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000269

metaR B3GALT5g
name: Beta-1,3-galactosyltransferase 5
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000269

metaR r2097
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR r0718
type: Reaction
is described by: ECO:0000000
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.181
reactant: MODEL1310110010#

metaM 4abutn e
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:58264
name: 4-ammoniobutanal
is: HMDB01080
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
type: Species

metaM itp e
is: SBO:0000247
is: CHEBI:57614
name: ITP(3-)
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
boundary condition: false
is: HMDB00189
initial concentration: 1.0
constant: false
type: Species

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM ksi pre27 g
is: CHEBI:58053
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 27
is: HMDB00175
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
boundary condition: false
is: C00130

metaM ha e
constant: false
has only substance units: false
name: hyaluronan
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16336
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_b3baaa16_90cc_491f_9cc5_5a583322ddb1
initial amount: NaN
is encoded by: hsa:249
is: B7Z4Y6
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: ALPL

metaR r2331
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110010#

metaM odecoa r
type: Species
boundary condition: false
initial concentration: 1.0
name: oleoyl-CoA(4-)
is: HMDB01322
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57387
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
initial amount: NaN

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM prostgd2 c
constant: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01403
initial concentration: 1.0
name: prostaglandin D2(1-)
has only substance units: false
is: CHEBI:57406

http://identifiers.org/biomodels.db/MODEL1310110010#_48dff825_1db0_452d_acc6_c77b3e57470f
has only substance units: false
name: DPM3
type: Species
is: Q9P2X0
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54344
boundary condition: true
initial amount: NaN
constant: false

metaR FAOXC226
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
name: Beta oxidation of long chain fatty acid

metaM gluside hs c
name: D-glucosyl-N-acylsphingosine
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:18368
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190

metaR CYTK2n
is described by: ECO:0000269
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000176
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
type: Reaction
product: MODEL1310110010#
name: cytidylate kinase (dCMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110010#_15fe572a_04a6_420f_bbd0_b859a211f8eb
is: O43678
initial concentration: NaN
boundary condition: true
name: NDUFA2
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:4695
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_4d7f3539_7f0e_44c5_81b3_cc401cef7bf5
is: P80404
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: ABAT
initial concentration: NaN
has only substance units: false
is encoded by: hsa:18

metaR r1814
modifier: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110010#
reversible: false
type: Reaction

metaR r2096
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110010#
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110010#
reversible: true
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction

metaR r1600
type: Reaction
reversible: true
product: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false

metaR KYNAKGAT
is version of: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reactant: MODEL1310110010#
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
kinetic law: MODEL1310110010#
fast: false

metaR r0717
is: SBO:0000176
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
is described by: ECO:0000000

metaR GGH 6DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110010#
reactant: MODEL1310110010#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false

metaR CO2tp
fast: false
reactant: MODEL1310110010#
is: SBO:0000185
type: Reaction
name: CO2 peroxisomal transport
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
product: MODEL1310110010#

metaR S6T6g
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110010#
type: Reaction
reversible: false
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#

metaM 5aop m
is: HMDB01149
is: SBO:0000247
is: C00430
constant: false
initial concentration: 1.0
name: 5-Amino-4-oxopentanoate
has only substance units: false
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
boundary condition: false
initial amount: NaN
is: CHEBI:17549

metaR r0246
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110010#
is: SBO:0000176

metaM thbpt c
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
initial concentration: 1.0
name: 5,6,7,8-tetrahydrobiopterin
is: SBO:0000247
constant: false
is: HMDB00027
initial amount: NaN
is: CHEBI:15372
type: Species
boundary condition: false
has only substance units: false

metaR r2332
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR PROSTGH2t
reactant: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000185
fast: false
name: Prostaglandin H2 transport
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:

metaR r0796
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
kinetic law: MODEL1310110010#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reversible: true
fast: false
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000

metaM ksii core2 pre3 g
boundary condition: false
has only substance units: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 3
is: CHEBI:58053
initial concentration: 1.0
is: C00130
is: HMDB00175
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C47H76N4O33X CHARGE: -1

metaR r0437
reversible: true
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110010#
fast: false
product: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_2b857b20_03da_4350_bf42_4d1da83e5a75
is encoded by: hsa:57419
boundary condition: true
is: SBO:0000252
is: Q9HC58
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: SLC24A3
has only substance units: false

metaR VITD3tm3
is described by: ECO:0000000
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
name: Vitamin D3 transport in mitochondria
fast: false
reversible: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is transported from cytosol in mitochondria based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT

http://identifiers.org/biomodels.db/MODEL1310110010#_b61c9b87_0f7f_4d3e_8cc0_f0317019b7dc
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:171425
is: Q8N0X4
initial concentration: NaN
is: SBO:0000252
name: CLYBL
type: Species

metaR RE0958E
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
type: Reaction
modifier: MODEL1310110010#
product: MODEL1310110010#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110010#
name: RE0958
is version of: http://identifiers.org/ec-code/3.2.1.1

metaR PPA
fast: false
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
type: Reaction
name: inorganic diphosphatase
is version of: http://identifiers.org/ec-code/3.6.1.1
product: MODEL1310110010#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#

metaR r1540
modifier: MODEL1310110010#
reversible: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_03530731_e07e_40dc_ab99_0dbdbafc2ffb
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: B7Z6Q4
name: IMPA1
type: Species
is encoded by: hsa:3612
constant: false
has only substance units: false
boundary condition: true

metaR RE1523M
reactant: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: RE1523
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR r0643
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
reactant: MODEL1310110010#
is: SBO:0000176
type: Reaction
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reversible: true
product: MODEL1310110010#
is described by: ECO:0000000

metaR DURAD
modifier: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is version of: http://identifiers.org/ec-code/1.3.1.2
fast: false
kinetic law: MODEL1310110010#
type: Reaction
reversible: true
reactant: MODEL1310110010#
product: MODEL1310110010#
name: dihydrouracil dehydrogenase (NADP)
is described by: ECO:0000269

metaM xoltetrol c
initial concentration: 1.0
constant: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: HMDB01231
type: Species
is: CHEBI:17278
has only substance units: false
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
initial amount: NaN
boundary condition: false

metaR RE2069C
product: MODEL1310110010#
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000176
fast: false
name: RE2069
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_8f39786d_340a_40b9_8928_047f43b4bcfc
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6390
is: SBO:0000252
is: P21912
name: SDHB
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_212725b3_44ee_47fb_b5ae_828635efa7ca
name: SLC35A1
is: P78382
has only substance units: false
is encoded by: hsa:10559
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252

metaM CE5160 r
initial amount: NaN
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
has only substance units: false
is: SBO:0000247
name: 3-oxo-cis-9-octadecenoyl-CoA
is: CHEBI:12947

metaR H2Otg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
name: H2O transport, Golgi apparatus

metaM ocdcea c
is: CHEBI:0
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: octadecenoate (n-C18:1)
is: C00712

metaR DOLPMT3 Uer
reversible: false
reactant: MODEL1310110010#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.260
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
fast: false
is: SBO:0000176
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM leuktrC4 e
name: leukotriene C4(2-)
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:57973
is: HMDB01198
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

http://identifiers.org/biomodels.db/MODEL1310110010#_23e5234c_28b2_47ec_a205_b8d8a154e6fc
initial amount: NaN
constant: false
is: Q9HAB8
initial concentration: NaN
is: SBO:0000252
type: Species
name: PPCS
boundary condition: true
has only substance units: false
is encoded by: hsa:79717

metaR NH4tn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
fast: false
name: ammonia nuclear transport
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000000

metaM dcholcoa r
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
initial amount: NaN
initial concentration: 1.0
constant: false
name: chenodeoxycholoyl coenzyme a
is: HMDB06292
has only substance units: false

metaR RE1518M
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
name: RE1518
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
reversible: true
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13

metaR H2Oter
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110010#
reversible: true
name: H2O endoplasmic reticulum transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110010#

metaR r1106
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110010#
name: Postulated transport reaction
fast: false
kinetic law: MODEL1310110010#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.56
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.3.86
type: Reaction
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is described by: ECO:0000269
reactant: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is: SBO:0000176
product: MODEL1310110010#

metaM h2o e
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB02111
initial amount: NaN
is: SBO:0000247
is: CHEBI:15377
has only substance units: false
type: Species
name: H2O

metaM arach c
constant: false
is: HMDB02212
name: arachidate
initial concentration: 1.0
is: CHEBI:32360
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: SBO:0000247

metaM ksi pre28 g
type: Species
has only substance units: false
is: HMDB00175
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: SBO:0000247
boundary condition: false
constant: false
name: keratan sulfate I biosynthesis, precursor 28
is: CHEBI:58053
is: C00130

metaR r0642
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110010#
type: Reaction
fast: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_a2a180f2_c18d_486a_bf1a_fd86db6d312d
is: O15056
boundary condition: true
type: Species
is encoded by: hsa:8871
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: SYNJ2
is: SBO:0000252

metaM 2maacoa m
name: 2-methylacetoacetyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57335
initial concentration: 1.0
has only substance units: false
is: HMDB01157

metaM ksii core4 pre7 g
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: C00130
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: HMDB00175
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 7
is: CHEBI:58053
boundary condition: false

metaM leuktrE4 c
name: leukotriene E4(1-)
boundary condition: false
is: HMDB02200
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
constant: false
has only substance units: false

metaR UMPK7n
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
name: UMP kinase (dGTP),nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_8fb41416_f277_4fc1_acdb_be501df34685
is encoded by: hsa:1374
boundary condition: true
constant: false
initial concentration: NaN
is: Q8WZ48
initial amount: NaN
name: CPT1A
has only substance units: false
is: SBO:0000252
type: Species

metaR ABUTD
reactant: MODEL1310110010#
is: SBO:0000176
name: Aminobutyraldehyde dehydrogenase
reversible: false
fast: false
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
kinetic law: MODEL1310110010#
is described by: ECO:0000269
modifier: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM pi c
constant: false
initial amount: NaN
boundary condition: false
name: hydrogenphosphate
is: HMDB00973
initial concentration: 1.0
is: C00009
has only substance units: false
type: Species
is: CHEBI:43474
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2

metaM dcyt n
is: CHEBI:15698
is: SBO:0000247
is: HMDB00014
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: 2'-deoxycytidine

metaR HYXNt
kinetic law: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
modifier: MODEL1310110010#
reversible: true
type: Reaction
reactant: MODEL1310110010#
fast: false
name: Hypoxanthine transport
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_7cdd8cff_2b6d_418c_96f6_79d618477f00
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:2030
has only substance units: false
is: Q99808
initial amount: NaN
name: SLC29A1
type: Species
initial concentration: NaN

metaR r1429
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
type: Reaction
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: Free diffusion
is described by: ECO:0000000

metaR ALAGLNexR
modifier: MODEL1310110010#
reversible: true
product: MODEL1310110010#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
kinetic law: MODEL1310110010#
type: Reaction
name: L-alanine/glutamine reversible exchange
reactant: MODEL1310110010#

metaM dadp c
initial concentration: 1.0
is: HMDB01508
has only substance units: false
name: dADP
is: SBO:0000247
constant: false
initial amount: NaN
is: C00206
type: Species
boundary condition: false
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

http://identifiers.org/biomodels.db/MODEL1310110010#_b371fbf3_6218_43e3_a6ff_1d01f47148b7
boundary condition: true
initial concentration: NaN
is: Q9P019
is encoded by: hsa:29085
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: PHPT1
initial amount: NaN

metaM crm hs r
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
initial concentration: 1.0
is: CHEBI:52639
has only substance units: false
name: N-acylsphingosine
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR C226CPT1
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
name: carnitine C22:6 transferase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_ee13045b_3dbc_4622_ac2f_11e94b4883f9
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI620219
constant: false
name: _AI620219_1_c
boundary condition: true
is: SBO:0000252

metaR GTMLTe
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000269
fast: false
name: g-glutamyltransferase (e)
reversible: false
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110010#
is: SBO:0000185
type: Reaction

metaR G14T20g
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110010#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000

metaM 34dhoxmand m
boundary condition: false
name: 3,4-Dihydroxymandelate
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:27637
type: Species
is: HMDB01866
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580

metaM HC00695 m
boundary condition: false
has only substance units: false
name: S-Succinyldihydrolipoamide
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: CHEBI:17432

metaR DTTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dTTP diffusion in nucleus
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110010#
reactant: MODEL1310110010#

metaM ocdcea e
notes: FORMULA: C18H33O2 CHARGE: -1
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:0
initial concentration: 1.0
boundary condition: false
name: octadecenoate (n-C18:1)
initial amount: NaN
type: Species
is: C00712
is: HMDB00207

metaR GLYSNAT5tc
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR DAGK hs
is version of: http://identifiers.org/ec-code/2.7.1.107
fast: false
name: Diacylglycerol phosphate kinase (homo sapiens)
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000269
reversible: true
type: Reaction

metaR r2419
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110010#

metaR SIAASE3ly
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
name: sialidase, lysosomal
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110010#

metaR C226CPT2
product: MODEL1310110010#
reversible: false
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000000
modifier: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is: SBO:0000176
name: C226 transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_4b188caa_91de_4abc_998f_d520431bba88
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: P16442
is encoded by: hsa:28
constant: false
name: ABO
initial concentration: NaN

metaM for r
initial concentration: 1.0
is: HMDB00142
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:15740
is: C00058
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: Formate
initial amount: NaN
type: Species

metaM bildglcur e
constant: false
is: CHEBI:58471
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB03325
has only substance units: false

metaM cholcoar x
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:58677
has only substance units: false
is: HMDB02178
type: Species
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial amount: NaN
initial concentration: 1.0

metaM h2o g
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
name: water
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB02111
is: SBO:0000247
boundary condition: false

metaR r0644
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110010#
is: SBO:0000176
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
type: Reaction
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#

metaR D 3AIBt
name: D-3-amino-isobutyrate transport
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110010#
product: MODEL1310110010#

metaM arach e
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
initial concentration: 1.0
is: CHEBI:32360
name: arachidate
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB02212

metaR r1428
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reactant: MODEL1310110010#
reversible: true
name: Free diffusion
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000

metaM homoval m
is: CHEBI:545959
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00118
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
has only substance units: false
type: Species
name: Homovanillate

metaR r0051
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
product: MODEL1310110010#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reactant: MODEL1310110010#

metaM pi e
is: HMDB00973
boundary condition: false
name: hydrogenphosphate
is: C00009
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:43474
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_4cbee1cc_1c3f_4240_907e_091d1b05ba11
constant: false
is: O75521
is encoded by: hsa:10455
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: ECI2
initial concentration: NaN
is: SBO:0000252

metaM ksi pre2 g
constant: false
is: SBO:0000247
notes: FORMULA: C87H142N6O62X CHARGE: -1
has only substance units: false
is: CHEBI:58053
is: C00130
name: keratan sulfate I biosynthesis, precursor 2
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00175
boundary condition: false

metaR FAOXC260240x
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
kinetic law: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110010#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110010#

metaR r0584
is described by: ECO:0000000
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
modifier: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
kinetic law: MODEL1310110010#

metaR PIt7
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
fast: false
name: phosphate transport in/out via three Na+ symporter
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
is described by: ECO:0000269
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_cda54597_ee60_4900_bf35_35bd48649f23
name: SULT1A2
is: P50226
boundary condition: true
is encoded by: hsa:6799
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_562959c8_2bad_4ef6_8778_782693236db4
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2954
type: Species
is: O43708
name: GSTZ1
initial amount: NaN

metaM gthox m
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB03337
is: CHEBI:58297
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_eb5b8b77_be4e_4b88_ac0c_c40665e6fca9
has only substance units: false
boundary condition: true
type: Species
is: Q86SF2
constant: false
is: SBO:0000252
name: GALNT7
is encoded by: hsa:51809
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_2460f575_babe_4256_ae58_920444738ef7
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: Q86U05
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23428
name: SLC7A8

metaR RE1709C
name: RE1709
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
type: Reaction
reversible: true
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110010#_0a627d27_4f07_4db1_9e73_64f91fb662fd
is: Q16790
name: CA9
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:768

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR r2352
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110010#

metaM HC01410 m
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
boundary condition: false
is: CHEBI:28706
initial concentration: 1.0
type: Species
initial amount: NaN
name: (2E)-Hexenoyl-CoA
constant: false
is: SBO:0000247
has only substance units: false

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_7624e149_a3ea_4b3f_8ca1_8a6b5ff54cf1
type: Species
is encoded by: hsa:51079
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: NDUFA13
boundary condition: true
has only substance units: false
is: Q9P0J0

metaR CORE6GTg
fast: false
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
is described by: ECO:0000000
reversible: false
is: SBO:0000176
modifier: MODEL1310110010#
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_4ae5f811_edf1_4c3c_b1d6_e631403b8839
name: SLC12A4
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6560
is: F5H066
constant: false

metaR UPPN
fast: false
name: b-ureidopropionase
is: SBO:0000176
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
product: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.6
modifier: MODEL1310110010#
reactant: MODEL1310110010#

metaM tdcoa c
is: C02593
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57385
initial amount: NaN
is: HMDB01521
has only substance units: false
constant: false

metaR r0647
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reversible: true
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
name: Spontaneous reaction

metaR 2HCO3 NAt
modifier: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000269
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
kinetic law: MODEL1310110010#
fast: false
type: Reaction

metaR GLYt4
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
type: Reaction
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110010#
reversible: false
name: glycine transport via sodium symport
modifier: MODEL1310110010#

metaR PIt8
product: MODEL1310110010#
name: phosphate transport in/out via Na+ symporter
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
fast: false
modifier: MODEL1310110010#
is described by: ECO:0000006
type: Reaction
reversible: true

metaR OCDCAtr
is: SBO:0000185
is described by: ECO:0000000
name: fatty acid transport via diffusion
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reactant: MODEL1310110010#
reversible: true
fast: false

metaR CHATn
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
name: Choline O-acetyltransferase
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.6
is described by: ECO:0000269
kinetic law: MODEL1310110010#
fast: false
modifier: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110010#

metaR r1298
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000000
name: Vesicular transport

http://identifiers.org/biomodels.db/MODEL1310110010#_19e24326_a9d7_42f0_8083_ca64dc9dcb8b
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SLC38A2
is: SBO:0000252
is: Q96QD8
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:54407

http://identifiers.org/biomodels.db/MODEL1310110010#_fbbf2969_c5be_424e_86a3_76925eb9d0a9
type: Species
is: Q8TF71
initial concentration: NaN
is encoded by: hsa:117247
constant: false
has only substance units: false
name: SLC16A10
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR BILIRUBtr
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR S6TASE25ly
product: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110010#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
is: SBO:0000176
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110010#_110a8098_02f3_4959_a007_760a0286e407
is: B7Z6M3
is encoded by: hsa:8525
initial concentration: NaN
name: DGKZ
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_a7fdeaab_694e_4ed8_82b7_4d3997347116
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:AI761708
has only substance units: false
name: _AI761708_1_m
type: Species
initial concentration: NaN
boundary condition: true

metaM cytd c
type: Species
is: HMDB00089
constant: false
name: Cytidine
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: CHEBI:17562
is: SBO:0000247
is: C00475
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_5412c858_c988_4634_9307_fa1607a934a6
is: P30613
constant: false
is encoded by: hsa:5313
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PKLR
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_040676ce_51ed_4436_b5b5_a771150de2f3
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:R39999
name: _R39999_1_c
boundary condition: true
has only substance units: false
constant: false

metaM dgcholcoa x
name: Chenodeoxyglycocholoyl-CoA
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB06897
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24?,25-,26+,27?,28?,29?,30+,31+,34?,36+,37+,38?,42+,44-,45+/m0/s1 EHMN_ABBREVIATION: C05461
type: Species
initial concentration: 1.0
is: C05461
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_9726cead_f175_4dab_8b75_5a66d0b83566
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: UGP2
is: SBO:0000252
is encoded by: hsa:7360
is: Q16851
type: Species
boundary condition: true

metaR r1109
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
is described by: ECO:0000000
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
fast: false
type: Reaction
is: SBO:0000176

metaR M1316Mg
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.114
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
reversible: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_c14542ef_7849_4ffc_a68f_b3aeabee6952
is: O94778
name: AQP8
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:343
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_5f0f67ca_754c_4dca_8a18_44e2148dc83d
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _AF116616_1_m
is encoded by: hsa:AF116616

metaM dhdascb c
has only substance units: false
is: HMDB01264
initial amount: NaN
name: dehydroascorbide(1-)
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:58070
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_5bd5ea7e_bb8c_403c_b2ee_9c0b2eb830de
initial concentration: NaN
is: SBO:0000252
name: B3GALT5
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:10317

metaR KAS8
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is described by: ECO:0000269
is: SBO:0000176
name: b-ketoacyl synthetase (palmitate, n-C16:0)
type: Reaction
product: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false

metaR r1299
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110010#
is: SBO:0000185
fast: false
reactant: MODEL1310110010#
name: Vesicular transport

metaR r0989
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
is described by: ECO:0000000
name: Postulated transport reaction
is: SBO:0000185
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
product: MODEL1310110010#
type: Reaction

metaM ipdp x
is: CHEBI:128769
name: isopentenyl diphosphate(3-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01347
constant: false
boundary condition: false

metaM fald e
is: CHEBI:16842
is: HMDB01426
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
name: formaldehyde
initial amount: NaN
has only substance units: false

metaR BACCL
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000269
name: biotin-[acetyl-CoA-carboxylase] ligase
modifier: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false

metaM trdrd c
boundary condition: false
name: Reduced thioredoxin
constant: false
is: CHEBI:15967
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00342
type: Species
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342

metaM glyald m
is: CHEBI:17378
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01051
boundary condition: false
constant: false
name: D-glyceraldehyde

metaR r0423
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
is: SBO:0000176
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
fast: false

metaR r1050
is: SBO:0000185
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport

http://identifiers.org/biomodels.db/MODEL1310110010#_b0b9e370_83a5_40f4_bb8a_5c6cba1209f5
initial amount: NaN
is: Q96SL4
is encoded by: hsa:2882
name: GPX7
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_f281010f_f9e0_4cce_8740_811d9f781ac7
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:26289
boundary condition: true
name: AK5

metaM ps hs e
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: CHEBI:18303
name: phosphatidylserine
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_e42d2c83_55f4_4dd6_82cb_71cb7d8ea289
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q03393
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5805
name: PTS
has only substance units: false

metaR r2354
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110010#
is: SBO:0000185

metaR LNLNCGt
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110010#
type: Reaction
reversible: true
fast: false

metaM 4ppan c
has only substance units: false
name: D-4'-Phosphopantothenate
initial concentration: 1.0
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: C03492
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:10986
is: HMDB01016
boundary condition: false

metaM retinal r
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: retinal
is: SBO:0000247
initial amount: NaN
is: HMDB01358
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
boundary condition: false
is: CHEBI:15035

metaR FACOAL244 1
name: fatty-acid--CoA ligase
reactant: MODEL1310110010#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#

metaM HC01403 x
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
name: (S)-Hydroxydecanoyl-CoA
is: CHEBI:28325
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264

metaR G14T8g
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110010#
is described by: ECO:0000000
modifier: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000176
reactant: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_7fee9274_f5b3_48e6_9cab_9074e9ae9ae4
initial amount: NaN
type: Species
is: P08236
has only substance units: false
is: SBO:0000252
name: GUSB
is encoded by: hsa:2990
constant: false
boundary condition: true
initial concentration: NaN

metaM dctp n
is: HMDB00998
is: SBO:0000247
is: CHEBI:16311
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
type: Species
name: dCTP
has only substance units: false
initial concentration: 1.0
constant: false
is: C00458

http://identifiers.org/biomodels.db/MODEL1310110010#_612c01c5_922d_4152_8349_d943b8c1f154
has only substance units: false
name: HMGCS2
is encoded by: hsa:3158
is: SBO:0000252
is: P54868
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_7724708a_b7ff_450c_9a72_8a5ed85d108e
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _H17063_1_c
is encoded by: hsa:H17063
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_89cb9a75_f387_4fb0_8097_73481d6752a7
is encoded by: hsa:10768
is: SBO:0000252
boundary condition: true
is: O43865
name: AHCYL1
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaM o2 m
constant: false
is: CHEBI:15379
type: Species
initial concentration: 1.0
name: O2
is: SBO:0000247
is: HMDB01377
boundary condition: false
is: C00007
has only substance units: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaR MAOX
name: Methylamine oxidase
reversible: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES:SAB
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.21

http://identifiers.org/biomodels.db/MODEL1310110010#_a923c9a3_ad45_4118_851f_ab98a0c083ce
initial concentration: NaN
is encoded by: hsa:50614
initial amount: NaN
constant: false
is: SBO:0000252
is: Q9HCQ5
type: Species
has only substance units: false
boundary condition: true
name: GALNT9

http://identifiers.org/biomodels.db/MODEL1310110010#_4872bc4c_64a6_4b69_858b_8419f319e511
initial amount: NaN
is: SBO:0000252
name: GLRX2
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51022
is: Q9NS18

metaR HMGCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
product: MODEL1310110010#
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
type: Reaction

metaR ASNtN1
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
name: Asparagine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110010#
is described by: ECO:0000269
reactant: MODEL1310110010#

metaR RE1233C
kinetic law: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
reversible: true
type: Reaction
modifier: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
name: RE1233
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64

http://identifiers.org/biomodels.db/MODEL1310110010#_b6663c4e_b84b_47d0_9d5a_23f34ca07e6f
constant: false
is encoded by: hsa:AI924226
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _AI924226_1_m
initial amount: NaN
boundary condition: true
type: Species

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_c00cfd19_04aa_48ac_98cc_adb504b373bf
type: Species
name: BTD
initial concentration: NaN
is encoded by: hsa:686
constant: false
is: P43251
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_7a62b2ad_e2d4_48aa_b7a1_1c197218d54d
name: AMY2B
is: P19961
is encoded by: hsa:280
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_c4527c64_d888_4db4_9e91_6c9af27d4d8a
has only substance units: false
is encoded by: hsa:2678
is: SBO:0000252
constant: false
boundary condition: true
name: GGT1
initial amount: NaN
initial concentration: NaN
type: Species

metaR SO4CLtex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: sulfate transport via chloride countertransport (2:1)
fast: false
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000304
modifier: MODEL1310110010#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_40963cd3_ed4d_4bea_9ad0_a3dc01fd526b
is encoded by: hsa:4126
is: O00462
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: MANBA

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR NADtru
product: MODEL1310110010#
reversible: false
is described by: ECO:0000000
name: NAD transporter, endoplasmic reticulum
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction

metaR r2353
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110010#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction

metaM cytd e
is: HMDB00089
constant: false
type: Species
is: CHEBI:17562
initial concentration: 1.0
is: SBO:0000247
name: Cytidine
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
initial amount: NaN
is: C00475
boundary condition: false
has only substance units: false

metaR r1051
name: Vesicular transport
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
product: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_fb04fa80_3635_4875_acfe_e2ab038a8ccd
boundary condition: true
initial concentration: NaN
is: Q99714
name: HSD17B10
type: Species
is: SBO:0000252
is encoded by: hsa:3028
has only substance units: false
initial amount: NaN
constant: false

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_8c1de5c6_cf80_4e82_9b38_b0491cfd01d2
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: B7Z3W8
name: SLC6A9
constant: false
has only substance units: false
is encoded by: hsa:6536
boundary condition: true

metaR GGH 5THFe
kinetic law: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
reversible: false
name: Gamma-glutamyl hydrolase (5THF), extracellular
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR r0580
is described by: ECO:0000000
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
is: SBO:0000176
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.99.7
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
product: MODEL1310110010#

metaR 2HBO
is described by: ECO:0000269
modifier: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110010#
type: Reaction
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reversible: true
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110010#_a42a2436_d14a_4a05_8a1b_9a653c4d367f
name: COX7B2
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:170712
initial concentration: NaN
is: SBO:0000252
is: Q8TF08
type: Species
has only substance units: false

metaR PHCHGSm
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
type: Reaction
reactant: MODEL1310110010#

metaR r2136
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#
reversible: false
is: SBO:0000185
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
product: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
fast: false

metaR It
fast: false
modifier: MODEL1310110010#
is described by: ECO:0000269
product: MODEL1310110010#
name: Iodide uniport
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_62679f1b_c17a_415c_b2fa_ba51272dd135
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6713
name: SQLE
initial amount: NaN
is: Q5HYI4
boundary condition: true

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaM crm hs g
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
is: CHEBI:52639
name: N-acylsphingosine
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN

metaR GGT6
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
reactant: MODEL1310110010#
name: Gamma-glutamyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ

http://identifiers.org/biomodels.db/MODEL1310110010#_e25748e2_6a4e_4757_95a9_9afcb1502231
is: P51857
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:6718
has only substance units: false
name: AKR1D1
constant: false
is: SBO:0000252

metaR GALASE18ly
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction

metaM pglyc hs c
is: SBO:0000247
notes: FORMULA: CHARGE: 0
type: Species
has only substance units: false
is: HMDB00156
boundary condition: false
is: CHEBI:15589
constant: false
name: pglyc_hs[c]
initial amount: NaN
initial concentration: 1.0

metaR biomass reaction
reversible: false
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: biomass_reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110010#_529619bc_231c_4088_89b3_2a8c3cfeec50
is: SBO:0000252
initial concentration: NaN
is: O75452
name: RDH16
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:8608
boundary condition: true
constant: false

metaM ocdcea l
initial concentration: 1.0
is: CHEBI:30823
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
name: oleate
constant: false
is: HMDB00207

http://identifiers.org/biomodels.db/MODEL1310110010#_4c0910be_e5be_495f_b4eb_cf9bca193859
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P09917
boundary condition: true
is encoded by: hsa:240
initial amount: NaN
name: ALOX5
type: Species
constant: false

metaR r1318
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
name: Transport reaction
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110010#

metaM dcyt e
name: Deoxycytidine
type: Species
has only substance units: false
constant: false
is: C00881
initial amount: NaN
is: CHEBI:15698
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
is: HMDB00014
initial concentration: 1.0
boundary condition: false

metaM c4crn c
type: Species
name: butyryl carnitine
is: C02862
constant: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144
notes: FORMULA: C11H21NO4 CHARGE: 0
is: HMDB02013
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR FADH2ETC
type: Reaction
reversible: false
name: Complex II reaction for respiratory chain
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000134

metaM Ssq23epx r
boundary condition: false
is: SBO:0000247
name: (S)-2,3-epoxysqualene
initial amount: NaN
has only substance units: false
is: CHEBI:15441
initial concentration: 1.0
type: Species
is: HMDB01188
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
constant: false

metaR BTND1
type: Reaction
reactant: MODEL1310110010#
name: biotinidase (biotin)
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.5.1.12
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_6ba6b084_2acd_4e2a_a858_4334bbbd9f46
initial concentration: NaN
is encoded by: hsa:56895
name: AGPAT4
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q9NRZ5
initial amount: NaN
constant: false
type: Species

metaM dgtp c
is: HMDB01440
type: Species
constant: false
name: dGTP
is: C00286
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
boundary condition: false
is: CHEBI:16497

metaR RAtn3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110010#
is: SBO:0000185
name: 13-cis-retinoic acid transport, nuclear
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_34fe1840_4379_4ded_97bd_d8dfb89c2622
is: SBO:0000252
constant: false
is: Q5JWV8
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ACSL4
is encoded by: hsa:2182
type: Species
has only substance units: false

metaR H2Otn
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
type: Reaction
is: SBO:0000185
name: H2O transport, nuclear
fast: false

metaM ksii core2 pre5 g
name: keratan sulfate II biosynthesis, precursor 5
is: C00130
notes: FORMULA: C61H99N5O43X CHARGE: -1
boundary condition: false
is: HMDB00175
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:58053
is: SBO:0000247
initial concentration: 1.0

metaR r0311
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
is: SBO:0000176
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000000

metaR G16MT U
fast: false
kinetic law: MODEL1310110010#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
is: SBO:0000176
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_652b202e_ab64_4160_8d7f_8ab86c975cb5
boundary condition: true
initial amount: NaN
has only substance units: false
name: DAD1:DDOST:RPN1:RPN2
initial concentration: NaN
constant: false
has part: Q53G02
is: SBO:0000297
is encoded by: hsa:1650
has part: P39656
is encoded by: hsa:6185
is encoded by: hsa:6184
is encoded by: hsa:1603
has part: P04844
type: Species
has part: P04843

metaR B3GNT39g
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110010#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110010#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_cd195af1_189d_4bba_b7bd_5c895c3cdb95
type: Species
name: _AA676725_1_c
is encoded by: hsa:AA676725
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaM mi13p c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18225
has only substance units: false
boundary condition: false
name: 1D-myo-Inositol 1,3-bisphosphate
is: SBO:0000247
is: HMDB06234
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
type: Species
constant: false

metaR G14T13g
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110010#
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR RE3002X
fast: false
modifier: MODEL1310110010#
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
name: RE3002

metaR H2Otm
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
product: MODEL1310110010#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
name: H2O transport, mitochondrial
type: Reaction
fast: false
modifier: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR C4CRNe
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaR FAOXC2442246x
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000269
reactant: MODEL1310110010#
reversible: false
is: SBO:0000176
fast: false

metaR ARSA
is version of: http://identifiers.org/ec-code/3.1.6.8
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
type: Reaction
modifier: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: Arylsulfatase A
product: MODEL1310110010#
is: SBO:0000176

metaM ach n
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: acetylcholine
is: SBO:0000247
boundary condition: false
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
constant: false
type: Species

metaR r0470
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110010#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110010#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_64e2195b_aca2_4078_b67b_03df6faeb967
boundary condition: true
is encoded by: hsa:197257
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: LDHD
is: SBO:0000252
type: Species

metaM dcyt c
name: Deoxycytidine
has only substance units: false
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
is: C00881
is: CHEBI:15698
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00014
boundary condition: false

metaM c4crn e
has only substance units: false
is: C02862
constant: false
is: SBO:0000247
initial amount: NaN
name: butyryl carnitine
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144
notes: FORMULA: C11H21NO4 CHARGE: 0
boundary condition: false
initial concentration: 1.0
type: Species

metaR F1Atg
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
name: F1alpha transport (from golgi to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110010#

metaR RETt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110010#
name: Retinol transport via faciliated diffusion
reversible: false
is described by: ECO:0000000
product: MODEL1310110010#
reactant: MODEL1310110010#

metaM dhor S c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30864
has only substance units: false
is: HMDB03349
name: (S)-dihydroorotate
constant: false
initial amount: NaN
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_5694ec34_d23a_4300_a1b6_62553c360dfb
boundary condition: true
name: _AI818585_1_c
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:AI818585
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_f5e19dd3_3a92_46a5_829b_2dd219558d8e
name: ACOT4
initial concentration: NaN
has only substance units: false
is encoded by: hsa:122970
is: Q8N9L9
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_ec4cfdc6_26a3_422c_86a9_8f3c1a9ee1f0
is: P14550
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10327
name: AKR1A1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_f1d90375_5b3a_4eb5_94b0_4e8ffc7845de
type: Species
constant: false
name: ACOT8
is encoded by: hsa:10005
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is: O14734
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_921a99e2_793a_418c_afe5_9fced14cadb4
is encoded by: hsa:4724
type: Species
is: O43181
name: NDUFS4
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaM tetpent6coa x
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
type: Species
name: tetracosapentaenoyl coenzyme A, n-6
boundary condition: false
initial concentration: 1.0
is: C16172
is: SBO:0000247

metaR O2St
product: MODEL1310110010#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
name: superoxide anion transport via diffusion (extracellular)
fast: false
type: Reaction

metaM dgtp e
has only substance units: false
is: CHEBI:16497
is: HMDB01440
boundary condition: false
initial amount: NaN
name: dGTP
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaM pan4p c
is: C01134
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
name: Pantetheine 4'-phosphate
is: SBO:0000247
boundary condition: false
is: HMDB01416
constant: false
initial amount: NaN
is: CHEBI:47942
initial concentration: 1.0
has only substance units: false
type: Species

metaR DNDPt22m
product: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dTDP transport via dUDP antiport

metaR RE1534M
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1534
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR BIOCYTtn
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
kinetic law: MODEL1310110010#
fast: false
name: biocytin transport, nuclear
product: MODEL1310110010#

metaR r0829
kinetic law: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110010#
reversible: true
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/4.1.1.37
modifier: MODEL1310110010#

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaR PHYCBOXL
kinetic law: MODEL1310110010#
reversible: false
product: MODEL1310110010#
modifier: MODEL1310110010#
name: L-Phenylalanine carboxy-lyase
type: Reaction
fast: false
is described by: ECO:0000212
reactant: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/4.1.1.28

metaR HPYRRy
product: MODEL1310110010#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.79
reversible: false
modifier: MODEL1310110010#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
kinetic law: MODEL1310110010#
name: Hydroxypyruvate reductase (NADPH)

metaR r2133
reactant: MODEL1310110010#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r0539
reversible: true
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
modifier: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
is described by: ECO:0000000
fast: false

metaR r0472
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110010#
type: Reaction

metaR AG13T16g
fast: false
modifier: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176

metaR GCHOLAtx
type: Reaction
reactant: MODEL1310110010#
name: bile acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR r1990
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_83f80347_9fc6_4754_ae0b_419dd0c5a942
is: A6NDW6
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ALG8
is encoded by: hsa:79053
type: Species
boundary condition: true
has only substance units: false
constant: false

metaR r0909
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
reactant: MODEL1310110010#
name: Transport reaction
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_b53ab9b7_3ab6_4689_ab04_dcdc2616fd46
type: Species
constant: false
name: AKR1C4
initial concentration: NaN
is: P17516
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1109
boundary condition: true
has only substance units: false

metaR r0908
reactant: MODEL1310110010#
is described by: ECO:0000000
name: Postulated transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
product: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
reversible: true

metaR r2132
reversible: true
is: SBO:0000185
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110010#

metaM ksi pre13 g
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 13
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00175
boundary condition: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: C00130

metaM o2 r
initial concentration: 1.0
name: O2
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:15379
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007

http://identifiers.org/biomodels.db/MODEL1310110010#_4088a876_c963_4e4d_9647_cc49159af5fa
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AL050025
name: _AL050025_1_c
has only substance units: false
constant: false
boundary condition: true

metaM ksii core4 pre10 g
boundary condition: false
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 10
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
type: Species

metaR RE3568C
reactant: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
name: RE3568
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_8b30071d_5a74_4231_a906_1e7d07a5283d
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: ACADS
has only substance units: false
is: P16219
is: SBO:0000252
is encoded by: hsa:35
initial concentration: NaN

metaR r0983
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110010#_989f1803_0f6e_4866_8806_b6b3f90c5397
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: LEFTY1
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10637
is: O75610

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR HAtly
is described by: ECO:0000000
reactant: MODEL1310110010#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110010#
kinetic law: MODEL1310110010#
name: hyaluronan transport, extracellular to lysosome
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_108de950_a809_4158_a61d_dbc901f63e9c
name: _AA278423_1_m
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:AA278423
initial amount: NaN

metaR TYMSFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
product: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false
name: Tyramine O-sulfate transport (diffusion)
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_73c958ed_0470_4cec_93e9_d0a4ead6cf1c
type: Species
is: Q99643
initial amount: NaN
name: SDHC
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6391
is: SBO:0000252

metaM pan4p e
has only substance units: false
is: SBO:0000247
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:47942
is: HMDB01416
type: Species
initial concentration: 1.0
is: C01134

metaR M16NTg
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
kinetic law: MODEL1310110010#
is: SBO:0000176
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.143
type: Reaction
product: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110010#

metaR r1291
is: SBO:0000185
name: Postulated transport reaction
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
reversible: true
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_b8ea466c_e2c7_42a1_a601_31bebeefaf76
is: SBO:0000252
is: Q53XN1
name: COX8A
is encoded by: hsa:1351
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaR FUMAC
reactant: MODEL1310110010#
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
name: fumarylacetoacetase
fast: false
is: SBO:0000176
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.7.1.2
reversible: false
type: Reaction

metaR SMPD4
product: MODEL1310110010#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
reversible: false
reactant: MODEL1310110010#
name: sphingomyelinase

http://identifiers.org/biomodels.db/MODEL1310110010#_42c8be4b_8a29_4e50_b800_1db97d4e5217
is encoded by: hsa:10991
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q99624
name: SLC38A3

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaM orot c
constant: false
is: SBO:0000247
name: Orotate
has only substance units: false
boundary condition: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30839
type: Species
is: HMDB00226
is: C00295

metaM lnlnca e
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:32387
has only substance units: false
is: HMDB01388
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
name: alpha-linolenate

metaR O2Stm
reactant: MODEL1310110010#
is described by: ECO:0000000
name: superoxide anion transport via diffusion (mitochondria)
kinetic law: MODEL1310110010#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110010#

metaR GDPFUCtg
is described by: ECO:0000269
modifier: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
fast: false
reactant: MODEL1310110010#
product: MODEL1310110010#
name: GDPFuc Golgi transport via CMP antiport
type: Reaction
reversible: true
kinetic law: MODEL1310110010#

metaR UDPGALtg
name: UDP-Gal Golgi transport via CMP antiport
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false

metaR AG13T9g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_07618561_468b_454b_926f_d5dd09f31180
initial amount: NaN
is: SBO:0000252
is: Q9NY97
boundary condition: true
name: B3GNT2
initial concentration: NaN
is encoded by: hsa:10678
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_40d87667_16d2_49f5_bb90_788d5efaca37
boundary condition: true
initial concentration: NaN
name: _D87002_1_e
has only substance units: false
constant: false
is encoded by: hsa:D87002
is: SBO:0000252
type: Species
initial amount: NaN

metaR r2131
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110010#
modifier: MODEL1310110010#

metaR BAAT1x
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
product: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
name: bile acid Coenzyme A: amino acid N-acyltransferase
is described by: ECO:0000269

metaR NACHEXA12ly
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000

metaR r1779
kinetic law: MODEL1310110010#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110010#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110010#

metaR MECOAS1m
product: MODEL1310110010#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110010#
type: Reaction
name: mesaconate--CoA ligase (GDP-forming)
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is: SBO:0000176
kinetic law: MODEL1310110010#
reversible: true
fast: false
reactant: MODEL1310110010#

metaM HC02210 e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
is: CHEBI:34939
constant: false
type: Species
name: prostaglandin-d3
has only substance units: false

metaR r0984
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#

metaM CE4793 x
type: Species
is: SBO:0000247
is: CHEBI:12947
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-28,30,34-36,40,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4793
name: 3-oxo-dihomo-gama-linolenoyl-CoA
constant: false
has only substance units: false

metaM f1a g
boundary condition: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: HMDB02917
has only substance units: false
is: SBO:0000247
name: F1alpha
type: Species
is: CHEBI:17151
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r1992
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110010#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR r0474
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110010#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110010#
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110010#

metaR TETPENT3t
kinetic law: MODEL1310110010#
is described by: ECO:0000000
name: fatty acid transport via diffusion
fast: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reactant: MODEL1310110010#
is: SBO:0000185
reversible: true

metaR RE1709N
modifier: MODEL1310110010#
name: RE1709
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: true
reactant: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
product: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_339ade87_427b_4fb0_8e05_1bea51695247
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: ALDH9A1
is encoded by: hsa:223
initial amount: NaN
is: P49189
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ae6fcc87_3e2f_4bac_ab45_922596cce743
is encoded by: hsa:8818
initial amount: NaN
name: DPM2
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_ac818e9b_7443_431e_a206_91f0a256a319
is encoded by: hsa:7108
name: TM7SF2
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: O76062

metaM HC00229 e
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:28189
name: Isomaltose
type: Species
boundary condition: false
initial amount: NaN

metaR EX gly LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Glycine
type: Reaction

metaR r1292
fast: false
name: Postulated transport reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110010#
type: Reaction
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#

metaR GLXO2p
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110010#
modifier: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.3.15
name: glyoxylate oxidase, peroxisomal

metaR r2130
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
modifier: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110010#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR UAG4E
name: UDP-N-acetylglucosamine 4-epimerase
reversible: true
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/5.1.3.2
modifier: MODEL1310110010#
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM ps hs m
boundary condition: false
is: CHEBI:18303
constant: false
has only substance units: false
is: SBO:0000247
name: ps_hs[m]
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
initial amount: NaN
type: Species

metaM pep c
initial concentration: 1.0
name: Phosphoenolpyruvate
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:18021
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: HMDB00263
is: C00074
boundary condition: false
type: Species

metaR r1538
reactant: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
type: Reaction
modifier: MODEL1310110010#
reversible: false
fast: false
name: Anion Exchanger (AE) TCDB:2.A.31.2.8

metaM bildglcur r
type: Species
is: CHEBI:58471
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB03325
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
name: bis(beta-glucosyluronate)bilirubin

metaR BALAtmr
is: SBO:0000185
kinetic law: MODEL1310110010#
product: MODEL1310110010#
name: Beta-alanine reversible mitochondrial transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110010#
is described by: ECO:0000000

metaR PETOHMr hs
is described by: ECO:0000254
modifier: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
name: phosphatidylethanolamine N-methyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.17
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
reactant: MODEL1310110010#
is: SBO:0000176

metaR r0310
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
reversible: false
fast: false
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
type: Reaction

metaR r0587
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
type: Reaction
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is: SBO:0000176
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
reversible: true
reactant: MODEL1310110010#

metaM C02528 r
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: HMDB00518
is: CHEBI:36234
name: chenodeoxycholate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_d166e1df_4d3e_47a1_ba5e_4244c72ba184
has only substance units: false
initial amount: NaN
boundary condition: true
name: SDHD
is encoded by: hsa:6392
constant: false
is: O14521
initial concentration: NaN
is: SBO:0000252
type: Species

metaR GLYt7 311 r
reactant: MODEL1310110010#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110010#
reversible: true
is described by: ECO:0000006
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is: SBO:0000185
product: MODEL1310110010#
modifier: MODEL1310110010#

metaR GGH 7THFe
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
product: MODEL1310110010#
reversible: false
type: Reaction
name: Gamma-glutamyl hydrolase (7THF), extracellular
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaM HC02210 c
name: prostaglandin-d3
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:34939
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false

metaR r0160
fast: false
reactant: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110010#
type: Reaction
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is version of: http://identifiers.org/ec-code/2.1.3.2

metaM orot e
has only substance units: false
is: CHEBI:30839
type: Species
boundary condition: false
constant: false
name: orotate
is: SBO:0000247
initial amount: NaN
is: HMDB00226
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

http://identifiers.org/biomodels.db/MODEL1310110010#_5c49036f_d92e_48ef_b0bb_59cf637fc0b9
is encoded by: hsa:5052
name: PRDX1
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM lnlnca c
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:32387
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
name: alpha-linolenate
is: HMDB01388

http://identifiers.org/biomodels.db/MODEL1310110010#_7bf3c0a0_76c3_41b6_aceb_cc6f4cc59f59
name: IMPA2
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: O14732
initial concentration: NaN
is encoded by: hsa:3613
is: SBO:0000252

metaM leuktrE4 e
type: Species
is: CHEBI:57462
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: leukotriene E4(1-)

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_b896a4cc_bdba_4ba4_b4f7_8cb98feebd3e
name: SOD2
initial amount: NaN
type: Species
constant: false
is: P04179
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6648

metaM udp r
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: HMDB00295
is: CHEBI:58223
name: UDP
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00015
initial concentration: 1.0
type: Species

metaM 5forthf c
name: 5-Formiminotetrahydrofolate
is: SBO:0000247
is: HMDB01534
has only substance units: false
is: C00664
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: CHEBI:57456
initial concentration: 1.0
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664

http://identifiers.org/biomodels.db/MODEL1310110010#_e06b3fb4_fa34_41dc_8bbe_96cea8bfeac9
initial amount: NaN
type: Species
constant: false
is: O75521
is encoded by: hsa:10455
initial concentration: NaN
name: ECI2
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_5696d1f6_e556_47a1_b133_a647280ec4ec
initial concentration: NaN
boundary condition: true
name: PTDSS1
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:9791
type: Species
is: P48651

metaM h2o c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0
is: HMDB02111
boundary condition: false
has only substance units: false
is: CHEBI:3303
is: C00001
type: Species
name: H2O
is: SBO:0000247
constant: false

metaR r0475
product: MODEL1310110010#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_b9ab6291_527f_429f_9b10_84f7b377cd43
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q99707
type: Species
initial amount: NaN
is encoded by: hsa:4548
has only substance units: false
name: MTR

metaM atp x
is: HMDB00538
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: C00002
constant: false
is: CHEBI:57299
has only substance units: false
name: ATP(4-)
initial amount: NaN

metaM akg e
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00208
initial concentration: 1.0
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
type: Species
name: 2-oxoglutarate(2-)

http://identifiers.org/biomodels.db/MODEL1310110010#_79c721dc_2f73_4456_aeb9_e6193c7f15c2
has only substance units: false
boundary condition: true
is encoded by: hsa:11112
is: P31937
constant: false
name: HIBADH
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaR SERGLYexR
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glycine reversible exchange
modifier: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110010#
product: MODEL1310110010#

metaM CE2838 e
name: maltononaose
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: SBO:0000247
is: C01936

metaR LTC4CP
name: Leukotriene C4 carboxypeptidase
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
product: MODEL1310110010#
reversible: true

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM ksi deg36 l
type: Species
is: CHEBI:12936
initial amount: NaN
name: keratan sulfate I, degradation product 36
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: HMDB00143
initial concentration: 1.0
constant: false

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_cfde2e13_4c82_4c52_95ea_2bc903a42100
name: _D29675_1_c
has only substance units: false
is encoded by: hsa:D29675
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

metaR r2069
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110010#
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_ae79771d_3908_4482_9676_2d47d95ce9b2
is: B3KTQ4
boundary condition: true
name: B3GALNT1
is encoded by: hsa:8706
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r0835
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110010#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#

metaM retinol cis 11 e
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB06216
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:16302
name: 11-cis-retinol

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaM clpn hs c
constant: false
is: SBO:0000247
is: HMDB00156
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: CHARGE: 0
is: CHEBI:15589
initial concentration: 1.0
boundary condition: false
name: clpn_hs[c]

metaM HC01403 m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
boundary condition: false
initial concentration: 1.0
type: Species
name: (S)-Hydroxydecanoyl-CoA
is: SBO:0000247
has only substance units: false
is: CHEBI:28325
constant: false
initial amount: NaN

metaM ksii core4 pre1 g
initial amount: NaN
notes: FORMULA: C36H60N3O25X CHARGE: 0
constant: false
name: keratan sulfate II biosynthesis, precursor 1
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
boundary condition: false

metaM chol n
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
initial concentration: 1.0
is: HMDB00097
has only substance units: false
type: Species
constant: false
boundary condition: false
is: CHEBI:15354
name: choline

metaR PI45P5P
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
fast: false
reactant: MODEL1310110010#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase

http://identifiers.org/biomodels.db/MODEL1310110010#_7730d4bb_1808_4b3e_8024_7db8b9b6279d
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: P43304
constant: false
is encoded by: hsa:2820
initial amount: NaN
name: GPD2

metaM strdnc l
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608
is: C16300
initial amount: NaN
name: stearidonic acid C18:4, n-3
is: HMDB06547
type: Species
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793

metaM 3pg c
is: SBO:0000247
constant: false
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00807
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3497
is: C00197
name: 3-Phospho-D-glycerate
is: CHEBI:58272

metaM pap c
name: adenosine 3',5'-bismonophosphate(4-)
type: Species
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
boundary condition: false
initial concentration: 1.0
is: CHEBI:58343
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00061

metaM glyb c
initial amount: NaN
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
boundary condition: false
is: CHEBI:17750
is: SBO:0000247
type: Species
initial concentration: 1.0
name: glycine betaine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_6d3716ae_9e3f_4e86_b573_c34a8baf1f6c
is: SBO:0000252
boundary condition: true
name: RFK
has only substance units: false
is: B2RDZ2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55312
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_42569439_eacf_470f_940c_8c2ee3e7f3df
name: CHST2
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:9435
has only substance units: false
is: Q9Y4C5
is: SBO:0000252

metaR r0834
is: SBO:0000185
kinetic law: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110010#
product: MODEL1310110010#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110010#
fast: false
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_aec17264_ad0c_4c03_a815_464df27804f3
initial amount: NaN
initial concentration: NaN
is: Q9HBF5
name: ST20
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:400410

metaM ala D c
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
constant: false
has only substance units: false
name: D-alanine
is: CHEBI:15570
is: HMDB01310
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM lnlnca r
is: CHEBI:32387
name: alpha-linolenate
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: SBO:0000247
is: HMDB01388
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM tmndnccoa x
name: timnodonyl coenzyme A
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
type: Species
initial concentration: 1.0
is: HMDB06514
initial amount: NaN

metaM tsul m
boundary condition: false
constant: false
name: thiosulfate(2-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB00257
has only substance units: false
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
is: CHEBI:16094

metaR COAtp
is described by: ECO:0000000
reversible: true
name: coenzyme A transport, peroxisomal
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#

metaR r0157
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is version of: http://identifiers.org/ec-code/6.3.4.2
type: Reaction
modifier: MODEL1310110010#
is: SBO:0000176

metaR ADSS
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
name: adenylosuccinate synthase
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134
reversible: false

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR DMATTx
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
modifier: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.1
reversible: false
name: dimethylallyltranstransferase

metaR TCHOLAte
name: bile acid intracellular transport
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
fast: false

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR ARACHCOAtx
product: MODEL1310110010#
is described by: ECO:0000000
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: fatty acid intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
fast: false
is: SBO:0000185

metaR FMNAT
reversible: false
type: Reaction
name: FMN adenylyltransferase
fast: false
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/2.7.7.2
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110010#
reactant: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_23b84ba5_85b5_4e02_9372_d39d78ff6e4a
initial amount: NaN
initial concentration: NaN
is: Q9Y6K8
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:26289
name: AK5

metaR NRPPHRSFt
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
is described by: ECO:0000000
type: Reaction
name: norepinephrine sulfate transport (diffusion)
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110010#

metaR r0531
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is version of: http://identifiers.org/ec-code/1.1.1.34
reversible: true
modifier: MODEL1310110010#
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:

metaR CHOLATEt
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
name: cholate transport via bicarbonate countertransport
reversible: true
reactant: MODEL1310110010#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_5be7c6fd_4937_4883_994e_26673d2d8e9e
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:10317
name: B3GALT5
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_47248f53_ec31_41e3_bb3a_fcc358f841e5
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9UJ70
name: NAGK
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55577
constant: false
type: Species

metaR GALASE12ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110010#
reversible: false
product: MODEL1310110010#
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110010#_ad9537f9_d4d7_4cfe_96e7_be4b581133a5
is encoded by: hsa:5333
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: P51178
name: PLCD1

metaR AKR1D
is version of: http://identifiers.org/ec-code/1.3.1.3
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110010#
is described by: ECO:0000269
modifier: MODEL1310110010#
reversible: false
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
product: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR RBFK
product: MODEL1310110010#
is described by: ECO:0000269
modifier: MODEL1310110010#
is: SBO:0000176
fast: false
name: riboflavin kinase
is version of: http://identifiers.org/ec-code/2.7.1.26
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_3b5ee30d_89e9_4497_8991_5ba36f82328e
is: Q99755
initial concentration: NaN
name: PIP5K1A
type: Species
is: SBO:0000252
is encoded by: hsa:8394
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_831f6f40_911f_456d_89d6_813e78b3d2c6
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: Q9UKG4
initial concentration: NaN
is encoded by: hsa:26266
name: SLC13A4
constant: false

metaR r2129
is described by: ECO:0000000
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110010#
type: Reaction
is: SBO:0000185

metaM pail45p hs c
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN

metaM C02528 e
boundary condition: false
is: HMDB00518
is: CHEBI:36234
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
name: chenodeoxycholate
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
type: Species

metaM f1a l
is: HMDB02917
type: Species
initial concentration: 1.0
is: SBO:0000247
name: F1alpha
notes: FORMULA: C22H37N2O15X CHARGE: 0
has only substance units: false
boundary condition: false
is: CHEBI:17151
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_aeab7c61_9384_489b_b46f_42bb4d63bc97
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9H2U2
name: PPA2
is encoded by: hsa:27068

metaM ptrc c
is: CHEBI:326268
is: HMDB01414
has only substance units: false
type: Species
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
name: Putrescine

metaR PRISTCOAtcx
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM 2dr5p c
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: SBO:0000247
type: Species
is: CHEBI:57651
initial amount: NaN
initial concentration: 1.0
is: HMDB01031
constant: false
boundary condition: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
has only substance units: false

metaR RE1903R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110010#
fast: false
reversible: true
product: MODEL1310110010#
name: RE1903
is described by: ECO:0000000
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_023f9b65_1871_42be_bf5d_6263b902c1f4
type: Species
initial amount: NaN
is: P48735
boundary condition: true
constant: false
name: IDH2
initial concentration: NaN
is encoded by: hsa:3418
has only substance units: false
is: SBO:0000252

metaR GULLACter
fast: false
is: SBO:0000185
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110010#
name: gulonolactone endoplasmic reticular transport
product: MODEL1310110010#
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_b703c4cb_003d_4919_a4cd_951062812ce3
is encoded by: hsa:4706
boundary condition: true
is: O14561
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: NDUFAB1
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_a4d87976_b102_46a3_8fcd_d0937e2eec10
boundary condition: true
is encoded by: hsa:8611
has only substance units: false
name: PPAP2A
is: G3XA95
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_ae1bfdb5_5455_454b_a30d_085b08451e54
type: Species
boundary condition: true
is encoded by: hsa:224
constant: false
is: P51648
name: ALDH3A2
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR TAGt
name: triacylglycerol transport
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110010#
is described by: ECO:0000000
type: Reaction

metaR S6T16g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
kinetic law: MODEL1310110010#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110010#
is: SBO:0000176
reversible: false
product: MODEL1310110010#
is described by: ECO:0000000
modifier: MODEL1310110010#

metaM 4abut c
initial amount: NaN
type: Species
constant: false
name: 4-Aminobutanoate
is: SBO:0000247
has only substance units: false
is: CHEBI:3628
is: HMDB00112
initial concentration: 1.0
boundary condition: false
is: C00334
notes: FORMULA: C4H9NO2 CHARGE: 0

metaM ksi pre36 g
has only substance units: false
constant: false
is: CHEBI:28067
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
name: keratan sulfate I biosynthesis, precursor 36
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247

metaR RE1810M
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110010#
name: RE1810

metaM dgtp n
type: Species
initial amount: NaN
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
is: C00286
has only substance units: false
boundary condition: false
name: dGTP
is: HMDB01440
constant: false
initial concentration: 1.0

metaM acgam l
type: Species
is: CHEBI:17411
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
name: N-acetyl-D-glucosamine
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

metaR COAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
reversible: true
type: Reaction
kinetic law: MODEL1310110010#
name: coenzyme A transport, nuclear

metaM tdcoa m
name: Tetradecanoyl-CoA (n-C14:0CoA)
constant: false
type: Species
is: CHEBI:57385
is: HMDB01521
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false
boundary condition: false
initial amount: NaN
is: C02593
is: SBO:0000247
initial concentration: 1.0

metaR TYROXDAc
is version of: http://identifiers.org/ec-code/1.4.3.4
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
fast: false
kinetic law: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
is: SBO:0000176
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
reactant: MODEL1310110010#
reversible: false
product: MODEL1310110010#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110010#_2303595f_72c3_4ef4_8978_5561ea8d3920
boundary condition: true
name: _H53099_1_m
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:H53099

http://identifiers.org/biomodels.db/MODEL1310110010#_60f95589_bdd2_4357_af32_a496411a804f
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: RPE
initial concentration: NaN
is encoded by: hsa:6120
is: Q53TV9
has only substance units: false
boundary condition: true

metaR URIt
is described by: ECO:0000269
fast: false
modifier: MODEL1310110010#
is: SBO:0000185
reversible: true
reactant: MODEL1310110010#
product: MODEL1310110010#
name: uridine facilated transport in cytosol
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_8e7e2ba2_29a2_4ab8_8599_42e503e9f5cd
is: Q9UQ53
name: MGAT4B
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:11282

metaR HMGCOAtm
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110010#
type: Reaction
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
reactant: MODEL1310110010#

metaR DM anth
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_83d9f08f_be49_4f2f_8514_a2c316e2e8b1
initial amount: NaN
initial concentration: NaN
name: PMVK
is: Q6FGV9
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:10654
is: SBO:0000252

metaM for c
has only substance units: false
is: C00058
initial amount: NaN
name: Formate
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00142
is: CHEBI:15740
type: Species
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058

http://identifiers.org/biomodels.db/MODEL1310110010#_eada9fc9_c051_4ad2_9785_d73b8dff911d
is: Q546Y9
boundary condition: true
is encoded by: hsa:57379
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: AICDA

metaR r1908
type: Reaction
kinetic law: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
reactant: MODEL1310110010#
reversible: false

metaM dadp n
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667
has only substance units: false
is: SBO:0000247
is: HMDB01508
name: dADP(3-)

metaR r0839
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
fast: false
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
reversible: true
name: Postulated transport reaction
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.3.1.70
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110010#_e79b9d68_2f93_4766_b2dd_175b8dc8fac7
type: Species
boundary condition: true
name: COX7C
constant: false
is: P15954
initial concentration: NaN
is encoded by: hsa:1350
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM cholcoaone x
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: HMDB06891
is: CHEBI:58507
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_43432eea_d50a_4a4f_95d4_943d070c2d5b
is: P34059
initial concentration: NaN
boundary condition: true
name: GALNS
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2588
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_a2245579_93e4_40bf_8a11_1d28921883a8
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1339
constant: false
boundary condition: true
name: COX6A2
type: Species
initial amount: NaN
is: Q02221
initial concentration: NaN

metaR ETHAK
reversible: false
product: MODEL1310110010#
notes: GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES:NCD
modifier: MODEL1310110010#
is: SBO:0000176
reactant: MODEL1310110010#
type: Reaction
name: Ethanolamine kinase
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.82
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.1.32

metaR GGH 5DHFe
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
modifier: MODEL1310110010#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reactant: MODEL1310110010#
product: MODEL1310110010#
fast: false
type: Reaction

metaR GAO1g
reversible: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
fast: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
name: Ganglioside O-acetylation
product: MODEL1310110010#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176

metaR r0911
reactant: MODEL1310110010#
type: Reaction
name: Facilitated diffusion
product: MODEL1310110010#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
is: SBO:0000185
reversible: true

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM pap g
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00061
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58343
name: adenosine 3',5'-bismonophosphate(4-)
constant: false

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_7a5a0a0c_067d_4e14_82ae_9a0c8f1daea4
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is: P18283
is encoded by: hsa:2877
initial concentration: NaN
constant: false
name: GPX2

http://identifiers.org/biomodels.db/MODEL1310110010#_d06e3117_50c4_4a26_9b47_33f8b47f53a5
name: SPTLC1:SPTLC2
has part: O15270
is encoded by: hsa:9517
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has part: O15269
is encoded by: hsa:10558
is: SBO:0000297

metaR PEAMNO
type: Reaction
name: Phenethylamine oxidase
fast: false
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000304
product: MODEL1310110010#
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21

metaR TSTSTERONEtr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
type: Reaction
reactant: MODEL1310110010#
reversible: true
kinetic law: MODEL1310110010#
product: MODEL1310110010#
fast: false
name: testosterone intracellular transport

metaR ALAGLYexR
modifier: MODEL1310110010#
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
name: L-alanine/glycine reversible exchange
kinetic law: MODEL1310110010#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110010#

metaM HC01603 c
name: 10-Formyltetrahydrofolate
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00234
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species

metaR HSD17B42x
product: MODEL1310110010#
is: SBO:0000176
name: hydroxysteroid (17-beta) dehydrogenase 4
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000269
modifier: MODEL1310110010#
type: Reaction
reversible: false

metaR r2127
reactant: MODEL1310110010#
product: MODEL1310110010#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110010#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaM chol r
is: HMDB00097
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:15354
initial concentration: 1.0
type: Species
constant: false
name: choline
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN

metaR A4GALTg
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
modifier: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.228
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110010#
name: Lactosylceramide 4-alpha-galactosyltransferase
product: MODEL1310110010#

metaM pan4p m
initial amount: NaN
is: CHEBI:47942
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
name: pantetheine 4'-phosphate(2-)

http://identifiers.org/biomodels.db/MODEL1310110010#_6efb73fb_7ff9_4742_9afd_cd7d8905b00e
is: Q14376
is encoded by: hsa:2582
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: GALE
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_bf710dec_5307_42e7_ad8f_e5d9a61cc62a
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9962
constant: false
name: SLC23A2
type: Species
has only substance units: false
is: SBO:0000252

metaM dadp m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN
type: Species
constant: false
name: dADP(3-)
is: CHEBI:57667
boundary condition: false

metaR r1907
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110010#
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
fast: false
reversible: false

metaR r0838
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
fast: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
is: SBO:0000185
name: Free diffusion
is described by: ECO:0000000
reactant: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.4

metaM acgam r
type: Species
initial amount: NaN
is: SBO:0000247
name: N-acetyl-D-glucosamine
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
is: CHEBI:17411
is: HMDB00215
constant: false
initial concentration: 1.0

metaR MI1PP
product: MODEL1310110010#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reactant: MODEL1310110010#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 1-phosphatase
kinetic law: MODEL1310110010#
fast: false
type: Reaction
modifier: MODEL1310110010#

metaR GASNASE3ly
name: glycosylasparaginase, lysosomal
is described by: ECO:0000000
product: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.26
fast: false
reactant: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#

metaM strdnc r
is: HMDB06547
is: http://identifiers.org/pubchem.compound/47205608
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
name: stearidonic acid C18:4, n-3
boundary condition: false
is: SBO:0000247
is: C16300
initial amount: NaN
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793

http://identifiers.org/biomodels.db/MODEL1310110010#_8ed84a5f_866d_47bb_93d8_c32c25c5f1db
boundary condition: true
initial amount: NaN
is encoded by: hsa:219
has only substance units: false
type: Species
name: ALDH1B1
initial concentration: NaN
constant: false
is: SBO:0000252
is: P30837

metaR PSDm hs
name: Phosphatidylserine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.65
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
reactant: MODEL1310110010#
reversible: false
is described by: ECO:0000269
product: MODEL1310110010#

metaR HISTAtu
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
type: Reaction
name: Histamine uniport
is described by: ECO:0000269
product: MODEL1310110010#
modifier: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
kinetic law: MODEL1310110010#
reversible: true

metaM acnam c
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:35418
is: HMDB00230
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
name: N-acetylneuraminate

metaM HC02203 e
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-a2
constant: false
type: Species

metaR r2128
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true

metaR NRPPHRt4 2 r
is described by: ECO:0000269
fast: false
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
name: Norepinephrine reversible transport in via sodium symport (1:2)
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_a52af896_e0ed_4ddf_98c3_51083ef8ffed
is encoded by: hsa:FLJ44968
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _FLJ44968_1_m
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_2ae1a16f_60d6_4a2e_866c_30118bece3ea
is encoded by: hsa:AI769281
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: _AI769281_1_e
has only substance units: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM retinal c
name: retinal
constant: false
type: Species
is: HMDB01358
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:15035

metaM atp r
type: Species
is: C00002
constant: false
name: ATP(4-)
is: CHEBI:57299
has only substance units: false
initial amount: NaN
is: HMDB00538
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_c25deab2_3713_4949_886f_0eb76ee0d479
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q14435
is encoded by: hsa:2591
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: GALNT3

http://identifiers.org/biomodels.db/MODEL1310110010#_2311f7cf_85ad_4c54_b7f0_4f8c3c9be4e6
initial concentration: NaN
is encoded by: hsa:570
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: BAAT
is: Q14032
constant: false
boundary condition: true

metaM for e
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00142
initial concentration: 1.0
boundary condition: false
name: formate
is: SBO:0000247
is: CHEBI:15740
type: Species
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058

metaR r0156
is: SBO:0000176
modifier: MODEL1310110010#
product: MODEL1310110010#
reversible: false
is described by: ECO:0000000
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
kinetic law: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110010#
type: Reaction

metaR r0317
is version of: http://identifiers.org/ec-code/1.4.4.2
fast: false
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reactant: MODEL1310110010#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110010#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110010#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10

metaM akg c
type: Species
is: SBO:0000247
is: C00026
constant: false
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
is: HMDB00208
name: 2-Oxoglutarate
has only substance units: false
is: CHEBI:16810
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_f57d518f_ba3a_44f2_aefd_d26d066e6fc3
is encoded by: hsa:T83654
constant: false
boundary condition: true
name: _T83654_1_c
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaR GCC2am
modifier: MODEL1310110010#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reversible: true
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110010#
is: SBO:0000176

metaR 2DR1PP
reversible: false
is described by: ECO:0000000
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
type: Reaction
reactant: MODEL1310110010#
fast: false
is: SBO:0000176
name: 2-deoxy-D-ribose 1-phosphate phosphorylase

metaR EX cysam LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cysam
type: Reaction

metaM mercplac c
initial amount: NaN
is: HMDB02127
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: 3-Mercaptolactate
is: http://identifiers.org/pubchem.compound/8118
is: C05823

http://identifiers.org/biomodels.db/MODEL1310110010#_afbd6d94_1580_4c65_96c5_fb9812d703ec
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI926493
type: Species
name: _AI926493_1_m
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR r2125
reversible: true
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110010#
fast: false
is: SBO:0000185
modifier: MODEL1310110010#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110010#
type: Reaction

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM ala D e
is: HMDB01310
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:15570
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
initial amount: NaN
constant: false
name: D-alanine

metaR r0836
is described by: ECO:0000000
reactant: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110010#

metaM lnlnca l
constant: false
is: CHEBI:32387
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: SBO:0000247
name: alpha-linolenate
type: Species
is: HMDB01388

metaR S6T5g
kinetic law: MODEL1310110010#
modifier: MODEL1310110010#
product: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction

metaM 7thf e
has only substance units: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB06559
name: heptaglutamyl folate (THF)
initial concentration: 1.0

metaM dcholcoa c
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
type: Species
is: CHEBI:28701
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB06292

metaR COAtr
is described by: ECO:0000000
reversible: true
fast: false
name: COA transporter, endoplasmic reticulum
type: Reaction
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110010#
kinetic law: MODEL1310110010#

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR RE3003M
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
product: MODEL1310110010#
reversible: true
is described by: ECO:0000000
name: RE3003
modifier: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM pi r
initial concentration: 1.0
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
name: hydrogenphosphate
is: HMDB00973
type: Species
initial amount: NaN
is: CHEBI:43474
is: C00009
constant: false
boundary condition: false

metaR PCHOL HSter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110010#
is described by: ECO:0000000
name: phosphatidylcholine scramblase
type: Reaction
reactant: MODEL1310110010#
fast: false
product: MODEL1310110010#

metaR RE1897C
is described by: ECO:0000000
name: RE1897
is: SBO:0000176
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
fast: false
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reversible: true

metaR ACACT1r
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.9
kinetic law: MODEL1310110010#
name: acetyl-CoA C-acetyltransferase
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000

metaR M16N4Tg
fast: false
kinetic law: MODEL1310110010#
is described by: ECO:0000000
name: alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.201 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000176
reversible: false

metaM HC02203 c
name: prostaglandin-a2
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
is: CHEBI:27820

http://identifiers.org/biomodels.db/MODEL1310110010#_ff5f0b01_2227_4308_b89e_87eea2e3e335
name: MAN1A2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: O60476
is encoded by: hsa:10905
has only substance units: false

metaM HC00718 c
is: SBO:0000247
is: CHEBI:57781
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
name: N-methylethanolaminium phosphate(1-)
has only substance units: false

metaM ksii core2 deg2 l
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
has only substance units: false
is: CHEBI:12936
constant: false
name: keratan sulfate II (core 2-linked), degradation product 2
is: SBO:0000247
type: Species
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
boundary condition: false

metaM oaa m
is: C00036
has only substance units: false
is: CHEBI:16452
initial concentration: 1.0
is: HMDB00223
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: Oxaloacetate
type: Species

metaM lnlncgcoa c
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57363
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM CE2420 m
is: SBO:0000247
is: HMDB11123
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:28387
constant: false
initial amount: NaN
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420

http://identifiers.org/biomodels.db/MODEL1310110010#_44c3aacf_37c7_4bbe_b7bc_0c240d9863d7
constant: false
is encoded by: hsa:1468
name: SLC25A10
initial concentration: NaN
type: Species
is: Q9UBX3
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r2126
modifier: MODEL1310110010#
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110010#
fast: false
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM b2coa m
is: HMDB02009
is: SBO:0000247
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
name: crotonoyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:57332
type: Species
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_f6def89c_e190_4df9_a5c1_364177dc3057
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:100287639
boundary condition: true
name: _100287639_1_c
constant: false

metaM tdcoa x
is: HMDB01521
is: SBO:0000247
initial amount: NaN
name: Tetradecanoyl-CoA (n-C14:0CoA)
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:57385
type: Species
is: C02593

W3 CDTF: Thu Aug 30 17:44:24 BST 2012

metaM 3mlda c
is: HMDB02820
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C05828
is: http://identifiers.org/pubchem.compound/8122
type: Species
constant: false
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
name: 3-Methylimidazoleacetic acid
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_a7a3c66a_2a5b_4d87_97a8_80b009e22749
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: B3GALT5
has only substance units: false
is encoded by: hsa:10317

metaM HC01399 m
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
has only substance units: false
constant: false
is: CHEBI:27466
name: (S)-3-Hydroxytetradecanoyl-CoA
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_942aba3d_2415_47d0_88e4_042ea99469ab
type: Species
is: SBO:0000252
is: Q96PE7
has only substance units: false
name: MCEE
initial concentration: NaN
is encoded by: hsa:84693
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_4eefc78f_0623_4789_82ad_c02b4d8faa93
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:7001
has only substance units: false
name: PRDX2
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110010#_7f97c66f_a31e_46f5_aac5_17c9211c5e84
type: Species
initial concentration: NaN
boundary condition: true
name: GRHPR
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9380
is: Q9UBQ7

metaR CBASPte
is described by: ECO:0000134
name: Transport of N-carbamoyl-L-aspartate
product: MODEL1310110010#
kinetic law: MODEL1310110010#
reversible: true
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
is: SBO:0000185

metaM lnlncg e
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
boundary condition: false
initial amount: NaN
name: gamma-linolenate
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB03073
is: SBO:0000247
is: CHEBI:32391
type: Species

metaR r0424
reversible: true
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110010#
is: SBO:0000176
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.17.1.4
fast: false
is described by: ECO:0000000

metaR G5SADrm
fast: false
reactant: MODEL1310110010#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
product: MODEL1310110010#
reversible: true
type: Reaction
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_47f610e1_f7bc_49c8_958b_ae4ef63df5b8
name: ENPP1
has only substance units: false
type: Species
initial concentration: NaN
is: P22413
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5167
initial amount: NaN

metaM ksi deg21 l
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 21
initial concentration: 1.0
has only substance units: false
is: HMDB00143
type: Species
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
constant: false

metaR GCHOLAte
reversible: true
product: MODEL1310110010#
reactant: MODEL1310110010#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110010#
name: bile acid intracellular transport

metaM xol7a r
name: 20-hydroxycholesterol
initial amount: NaN
boundary condition: false
is: CHEBI:1296
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
type: Species
is: HMDB01496
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110010#_412899d2_77ec_4eaa_87a2_dfc3733f3024
type: Species
boundary condition: true
constant: false
is encoded by: hsa:285973
has only substance units: false
is: SBO:0000252
name: ATG9B
initial amount: NaN
initial concentration: NaN
is: Q674R7

metaR TREHe
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
fast: false
is: SBO:0000176
name: alpha,alpha-trehalase
reactant: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.28
is described by: ECO:0000269
product: MODEL1310110010#

metaM ksi deg12 l
is: CHEBI:12936
has only substance units: false
type: Species
is: SBO:0000247
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 12
initial amount: NaN
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
is: HMDB00143
initial concentration: 1.0

W3 CDTF: Thu Aug 30 17:44:24 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110010#_302f0199_d1e4_4ed6_930e_d2f99923f4b6
type: Species
is encoded by: hsa:8693
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: Q8N4A0
has only substance units: false
name: GALNT4
initial concentration: NaN

metaM dolglcp U r
is: CHEBI:15812
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
initial concentration: 1.0

metaM ksi pre1 g
is: C00130
is: HMDB00175
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: CHEBI:58053
initial concentration: 1.0
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110010#_4d588ccb_59e0_450b_8798_33a720e89888
name: UPB1
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: B3KNC1
boundary condition: true
constant: false
is encoded by: hsa:51733

metaR G14T9g
product: MODEL1310110010#
is: SBO:0000176
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110010#
modifier: MODEL1310110010#

metaR MAL Lte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: Transport of L-malate
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_1a88d0f1_5e04_46d9_b6fa_34a909a15649
is encoded by: hsa:2544
has only substance units: false
constant: false
name: _2544_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110010#_a3546cc2_f8ad_4d68_a690_879b4991680e
constant: false
is encoded by: hsa:191
is: B3KUN3
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: AHCY
boundary condition: true

metaM ps hs c
is: CHEBI:18303
name: ps_hs[c]
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM ksii core2 pre4 g
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 4
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C53H86N4O38X CHARGE: -1
boundary condition: false
is: C00130
is: HMDB00175
constant: false

metaR r2344
fast: false
reversible: true
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110010#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110010#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110010#_3575d09a_08b7_4c73_8387_0017931ecc17
initial amount: NaN
type: Species
is encoded by: hsa:686
has only substance units: false
constant: false
name: BTD
initial concentration: NaN
boundary condition: true
is: P43251
is: SBO:0000252

metaR URIt5le
reversible: false
reactant: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: uridine transport in via sodium symport (1:2)
kinetic law: MODEL1310110010#
is described by: ECO:0000134
modifier: MODEL1310110010#

metaM ksi deg29 l
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: HMDB00143
constant: false
type: Species
is: SBO:0000247
name: keratan sulfate I, degradation product 29
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:12936

W3 CDTF: Thu Aug 30 17:44:25 BST 2012

metaR FRDPtcr
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000134
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
product: MODEL1310110010#
kinetic law: MODEL1310110010#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_08c4bed0_edca_444e_9b45_e810484ad843
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q8TCG5
initial amount: NaN
name: CPT1C
is encoded by: hsa:126129

http://identifiers.org/biomodels.db/MODEL1310110010#_d24a229b_f8d3_4ad6_96fd_331ee14febe9
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P37837
constant: false
is encoded by: hsa:6888
type: Species
name: TALDO1
boundary condition: true
initial concentration: NaN

metaM nmn c
initial concentration: 1.0
name: NMN
is: SBO:0000247
has only substance units: false
is: C00455
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: CHEBI:14649
type: Species
constant: false
initial amount: NaN
is: HMDB00229
boundary condition: false

metaM 9 cis retfa e
name: fatty acid 9-cis-retinol
initial amount: NaN
type: Species
has only substance units: false
is: HMDB06559
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM 3mlda e
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
is: http://identifiers.org/pubchem.compound/8122
is: SBO:0000247
initial amount: NaN
is: C05828
is: HMDB02820
name: 3-Methylimidazoleacetic acid

metaM pi m
is: C00009
initial concentration: 1.0
name: hydrogenphosphate
is: HMDB00973
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:43474
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

http://identifiers.org/biomodels.db/MODEL1310110010#_66b556ca_1aaa_40f5_81a5_9bc73aed3b7c
type: Species
initial concentration: NaN
name: NDUFA4
is encoded by: hsa:4697
is: O00483
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaR CORE4GTg
type: Reaction
reversible: false
reactant: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.102
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
kinetic law: MODEL1310110010#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110010#

metaM 2aobut m
has only substance units: false
boundary condition: false
type: Species
is: HMDB06454
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H7NO3 CHARGE: 0 INCHI: InChI=1S/C4H7NO3/c1-2(6)3(5)4(7)8/h3H,5H2,1H3,(H,7,8)/t3-/m0/s1 EHMN_ABBREVIATION: C03508
name: L-2-amino-3-oxobutanoic acid
is: CHEBI:40673

http://identifiers.org/biomodels.db/MODEL1310110010#_5c8cd074_c3af_4ea7_96b9_b210c1bfedc7
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: A1L4Q0
name: DGKE
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:8526

metaR r0426
reactant: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110010#
type: Reaction
modifier: MODEL1310110010#
is described by: ECO:0000000
fast: false
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.5.1.34

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaM gal1p c
is: SBO:0000247
constant: false
is: HMDB00645
is: CHEBI:58336
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
has only substance units: false

metaR COAtg
reversible: true
is: SBO:0000185
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
name: CoA transport in Golgi via diffusion
product: MODEL1310110010#
is described by: ECO:0000000
kinetic law: MODEL1310110010#
type: Reaction

metaR MTHFD
is version of: http://identifiers.org/ec-code/1.5.1.5
product: MODEL1310110010#
modifier: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110010#
name: methylenetetrahydrofolate dehydrogenase (NADP)
type: Reaction
kinetic law: MODEL1310110010#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y

metaM glcur r
name: D-glucuronate
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110010#_e8299cbd_b371_41e1_ba8c_db604f681d1a
is: Q6FGA0
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:9167
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: COX7A2L

metaR PROSTGE1t
product: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110010#
is described by: ECO:0000269
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110010#_5ab25940_0662_4290_9f14_8267311d436f
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: O15269
has only substance units: false
is encoded by: hsa:10558
name: SPTLC1
boundary condition: true
initial concentration: NaN

metaM imp c
is: CHEBI:58053
is: HMDB00175
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: C00130
initial amount: NaN
name: IMP
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
boundary condition: false
initial concentration: 1.0

metaM Tn antigen g
initial concentration: 1.0
is: C04383
notes: FORMULA: C8H14NO5X CHARGE: 0
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
name: Tn antigen
constant: false
boundary condition: false

W3 CDTF: Thu Aug 30 17:44:25 BST 2012

metaM tmndnccoa m
constant: false
boundary condition: false
type: Species
name: timnodonyl coenzyme A
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
has only substance units: false
is: HMDB06514
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_6ed48176_f902_42d8_baa9_096c8ed74ac9
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3157
constant: false
name: HMGCS1
boundary condition: true
type: Species
is: SBO:0000252

metaM pi n
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: hydrogenphosphate
is: SBO:0000247
is: HMDB00973
constant: false
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474

metaM hdcea r
is: HMDB03229
constant: false
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species
has only substance units: false
initial amount: NaN
name: palmitoleate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR BTNTe
kinetic law: MODEL1310110010#
product: MODEL1310110010#
reactant: MODEL1310110010#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of biotin across the basolatral membrane
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110010#_c1ffbc0d_99b7_4503_8588_33ca8612699b
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: Q96M60
is encoded by: hsa:196951
name: C15orf33
has only substance units: false
boundary condition: true

metaR r2346
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_d70c9ec3_fe04_445d_a0bc_8a0533326a0f
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8612
is: E9PAY8
name: PPAP2C
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false

metaR SQLSr
is version of: http://identifiers.org/ec-code/2.5.1.21
is described by: ECO:0000134
modifier: MODEL1310110010#
name: Squalene synthase
type: Reaction
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
fast: false
kinetic law: MODEL1310110010#
reversible: false
reactant: MODEL1310110010#
is: SBO:0000176
product: MODEL1310110010#

metaM chol e
name: Choline
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00097
is: CHEBI:15354
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114

metaR r0365
is described by: ECO:0000000
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
modifier: MODEL1310110010#
reversible: false
fast: false
kinetic law: MODEL1310110010#
type: Reaction
product: MODEL1310110010#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.72
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59

metaM amp x
constant: false
is: HMDB00045
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: AMP
is: CHEBI:456215
initial concentration: 1.0
boundary condition: false
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species

metaR MTHFC
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.5.1.5
fast: false
name: methenyltetrahydrofolate cyclohydrolase
modifier: MODEL1310110010#
is: SBO:0000176
type: Reaction
product: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_eb69eccc_23d4_47ea_987b_c466ca761047
initial concentration: NaN
initial amount: NaN
name: ACADSB
boundary condition: true
type: Species
constant: false
is encoded by: hsa:36
is: P45954
is: SBO:0000252
has only substance units: false

metaR r2062
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#

metaR r1421
reactant: MODEL1310110010#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
kinetic law: MODEL1310110010#
product: MODEL1310110010#
is: SBO:0000185
reversible: true
name: Free diffusion

http://identifiers.org/biomodels.db/MODEL1310110010#_99dba5b2_df8e_4849_b9db_c71e195cc90f
is: Q15181
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: PPA1
constant: false
initial amount: NaN
is encoded by: hsa:5464

http://identifiers.org/biomodels.db/MODEL1310110010#_ea6806ca_edc1_433a_a65f_aac8d0a0c715
is: Q7LG56
initial amount: NaN
is encoded by: hsa:50484
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
name: RRM2B
initial concentration: NaN

metaM pi g
is: HMDB00973
initial amount: NaN
name: hydrogenphosphate
type: Species
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:43474

metaR r0360
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
modifier: MODEL1310110010#
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/6.2.1.16
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110010#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reactant: MODEL1310110010#

metaM gthox c
type: Species
is: C00127
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: CHEBI:58297
has only substance units: false
name: Oxidized glutathione
is: HMDB03337

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR r2347
reactant: MODEL1310110010#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110010#
product: MODEL1310110010#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

metaR AKGMALtm
product: MODEL1310110010#
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110010#
modifier: MODEL1310110010#
name: alpha-ketoglutarate/malate transporter

metaM o2 c
constant: false
is: CHEBI:15379
type: Species
is: C00007
initial concentration: 1.0
has only substance units: false
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
name: O2
is: SBO:0000247
initial amount: NaN

metaR SUCCt2m
reactant: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
name: succinate transport, mitochondrial
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000269

metaM ptrc e
initial concentration: 1.0
is: C00134
initial amount: NaN
constant: false
is: HMDB01414
name: Putrescine
is: CHEBI:326268
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false

metaM thcrm hs g
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: trihexosyl ceramide
is: CHEBI:24636
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
has only substance units: false

metaM C02528 c
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial concentration: 1.0
boundary condition: false
is: HMDB00518
constant: false
initial amount: NaN
has only substance units: false
name: chenodeoxycholate
is: CHEBI:36234
is: SBO:0000247
type: Species

metaM utp c
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: C00075
name: UTP
is: CHEBI:46398
type: Species
is: HMDB00285
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110010#_f2016f5d_d61f_46cb_b489_c72ae5f2bc2b
initial concentration: NaN
type: Species
name: B4GALT2
is encoded by: hsa:8704
constant: false
initial amount: NaN
is: O60909
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110010#_af086527_b61d_4775_a605_f1fe847db32a
name: HMGCS2
type: Species
is encoded by: hsa:3158
is: SBO:0000252
is: P54868
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaR DOLPGT1 Uer
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is described by: ECO:0000000
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.267
is: SBO:0000176
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
reactant: MODEL1310110010#
type: Reaction
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110010#_d0b03342_47f5_4320_8b1b_7ac18d195237
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: _7359_1_c
is encoded by: hsa:7359

metaM ksii core2 pre6 g
constant: false
name: keratan sulfate II biosynthesis, precursor 6
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C61H98N5O46SX CHARGE: -2
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_0deb6917_f133_403b_805c_46bc49de22ab
name: DGAT1
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: O75907
type: Species
is encoded by: hsa:8694
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110010#_881307f9_769e_4478_88b5_0813cb0bcad7
has part: E5KS60
initial concentration: NaN
is encoded by: hsa:8803
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000297
name: SUCLG1:SUCLA2
boundary condition: true

metaR COAtm
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
product: MODEL1310110010#
is described by: ECO:0000269
kinetic law: MODEL1310110010#
is: SBO:0000185
reactant: MODEL1310110010#
type: Reaction
reversible: true
fast: false
name: CoA transporter
modifier: MODEL1310110010#

metaR Asn X Ser Thrtr
kinetic law: MODEL1310110010#
name: Asn-X-Ser/Thr transport (from ER to lysosome)
is: SBO:0000185
reactant: MODEL1310110010#
is described by: ECO:0000269
product: MODEL1310110010#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
type: Reaction
fast: false

metaR CYTK8n
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110010#
modifier: MODEL1310110010#
reactant: MODEL1310110010#
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (CMP,dATP),nuclear
fast: false
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

metaM 4abut e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0
type: Species
constant: false
name: 4-Aminobutanoate
is: CHEBI:3628
is: C00334
boundary condition: false
is: HMDB00112
has only substance units: false

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110010#
reactant: MODEL1310110010#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM but e
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00039
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
initial concentration: 1.0
boundary condition: false
type: Species

metaM gchola c
name: glycocholate
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58235
boundary condition: false
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
constant: false
is: HMDB00138
is: SBO:0000247
has only substance units: false

metaR r1427
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
kinetic law: MODEL1310110010#
is: SBO:0000185
product: MODEL1310110010#
reactant: MODEL1310110010#
fast: false
reversible: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

http://identifiers.org/biomodels.db/MODEL1310110010#_7475e53e_25db_4cc7_ae0c_cf7c4d32c579
is: Q5SYN6
boundary condition: true
type: Species
name: SLC22A3
is encoded by: hsa:6581
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaR G14T21g
kinetic law: MODEL1310110010#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
reversible: false
product: MODEL1310110010#
is: SBO:0000176
modifier: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR RE2985X
modifier: MODEL1310110010#
reversible: false
type: Reaction
reactant: MODEL1310110010#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE2985
is version of: http://identifiers.org/ec-code/1.17.99.3
is: SBO:0000176
product: MODEL1310110010#
is described by: ECO:0000000

metaM CE5114 x
name: trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,20-21,28-30,34-36,40,51-52H,4-7,10,13,16-19,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5114
boundary condition: false
is: CHEBI:12947
initial concentration: 1.0

metaM gthox e
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58297
is: HMDB03337
has only substance units: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
boundary condition: false
type: Species

metaR r0830
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
reversible: true
reactant: MODEL1310110010#
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110010#
product: MODEL1310110010#
modifier: MODEL1310110010#
is: SBO:0000185

metaR GTHP
reversible: true
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
reactant: MODEL1310110010#
modifier: MODEL1310110010#
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.11.1.9
is: SBO:0000176
is described by: ECO:0000134
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.15
type: Reaction
product: MODEL1310110010#
is version of: http://identifiers.org/ec-code/1.11.1.12
fast: false

http://identifiers.org/biomodels.db/MODEL1310110010#_634dd9ef_cc9c_4e87_a414_39ef0070a762
type: Species
is encoded by: hsa:80864
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is: Q99944
initial amount: NaN
initial concentration: NaN
name: EGFL8

metaR CYOR u10m
product: MODEL1310110010#
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.92
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
kinetic law: MODEL1310110010#
name: ubiquinol-6 cytochrome c reductase, Complex III
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_13758f96_474e_42a0_81eb_2d9ce1a82a11
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P07864
constant: false
boundary condition: true
is encoded by: hsa:3948
name: LDHC
type: Species

metaM gm3 hs g
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:60065
type: Species
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
boundary condition: false
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730

metaR FAOXC2051843x
product: MODEL1310110010#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110010#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110010#
notes: GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR 4NPHSULT
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110010#
type: Reaction
kinetic law: MODEL1310110010#
is version of: http://identifiers.org/ec-code/2.8.2.1
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
product: MODEL1310110010#
reversible: false
modifier: MODEL1310110010#
name: 4-Nitrophenol Sulfotransferase
fast: false

metaR CYTK10
name: cytidylate kinase (CMP,dGTP)
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110010#
kinetic law: MODEL1310110010#
fast: false
is described by: ECO:0000269
product: MODEL1310110010#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true

metaM utp e
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
initial concentration: 1.0
name: UTP(4-)
is: CHEBI:46398
is: HMDB00285
type: Species
is: SBO:0000247
initial amount: NaN

metaM 3pg m
is: HMDB00807
has only substance units: false
is: CHEBI:58272
is: SBO:0000247
initial concentration: 1.0
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
type: Species
constant: false
boundary condition: false
initial amount: NaN

metaM Tn antigen l
has only substance units: false
boundary condition: false
name: Tn antigen
is: C04383
type: Species
notes: FORMULA: C8H14NO5X CHARGE: 0
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110010#_2d640f63_7fe4_499a_9676_d54a152bb98b
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: MOXD1
is encoded by: hsa:26002
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q6UVY6

metaR r1805
product: MODEL1310110010#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110010#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110010#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110010#

http://identifiers.org/biomodels.db/MODEL1310110010#_35f20cda_c493_4a43_b0cb_fe64cd874d38
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: _BC005314_1_x
has only substance units: false
is encoded by: hsa:BC005314
constant: false

metaM tetpent6coa c
is: C16172
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
type: Species
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
name: tetracosapentaenoyl coenzyme A, n-6
boundary condition: false
initial concentration: 1.0

given: Ines
family: Thiele

ORG:
  orgname: University of Iceland