173571
constant: false
value: NaN
name: V_Na_Ca
type: Parameter

173231
constant: false
value: NaN
name: tau_n
type: Parameter

173207
constant: false
value: NaN
name: n_infinity
type: Parameter

173365
constant: true
value: 1400.0
name: g_Ca
type: Parameter

173340
constant: false
value: NaN
name: i_Ca
type: Parameter

173183
constant: true
value: 2500.0
name: g_K
type: Parameter

173667
constant: true
value: 0.03
name: k_Ca
type: Parameter

173159
constant: false
value: NaN
name: i_K
type: Parameter

173607
constant: false
value: 0.52
name: Ca_i
type: Parameter

173486
constant: true
value: NaN
name: time
type: Parameter

173292
constant: true
value: 6.0
name: c
type: Parameter

173135
constant: false
value: -76.0
name: V
type: Parameter

173534
constant: false
value: NaN
name: i_Na_Ca
type: Parameter

173377
constant: false
value: NaN
name: m_infinity
type: Parameter

173268
constant: true
value: 65.0
name: a
type: Parameter

173643
constant: true
value: 140.0
name: Na_o
type: Parameter

173438
constant: false
value: NaN
name: h
type: Parameter

173462
constant: true
value: -10.0
name: S_h
type: Parameter

173316
constant: true
value: NaN
name: V
type: Parameter

173111
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

173510
constant: true
value: 30000.0
name: g_K_Ca
type: Parameter

173595
constant: true
value: 5.0
name: nH
type: Parameter

173414
constant: true
value: NaN
name: V
type: Parameter

173243
constant: true
value: -15.0
name: V_n
type: Parameter

173583
constant: true
value: 26.54
name: RT_F
type: Parameter

173219
constant: true
value: 1.6
name: lamda
type: Parameter

173631
constant: true
value: 10.0
name: Na_i
type: Parameter

173450
constant: true
value: -10.0
name: V_h
type: Parameter

173352
constant: true
value: 110.0
name: V_Ca
type: Parameter

173280
constant: true
value: 20.0
name: b
type: Parameter

173546
constant: true
value: 234.0
name: g_Na_Ca
type: Parameter

173195
constant: false
value: 0.1
name: n
type: Parameter

173304
constant: true
value: -75.0
name: V_
type: Parameter

173256
constant: true
value: 5.6
name: S_n
type: Parameter

173389
constant: true
value: 4.0
name: V_m
type: Parameter

173619
constant: true
value: 2600.0
name: Ca_o
type: Parameter

173147
constant: true
value: 5310.0
name: Cm
type: Parameter

173679
constant: true
value: 4.5055E-6
name: alpha
type: Parameter

173498
constant: false
value: NaN
name: i_K_Ca
type: Parameter

173522
constant: true
value: 100.0
name: K_d
type: Parameter

173559
constant: true
value: 1.5
name: K_1_2
type: Parameter

173123
constant: true
value: NaN
name: time
type: Parameter

173402
constant: true
value: 14.0
name: S_m
type: Parameter

173171
constant: true
value: -75.0
name: V_K
type: Parameter

173426
constant: true
value: NaN
name: time
type: Parameter

173655
constant: true
value: 0.001
name: f
type: Parameter

173328
constant: true
value: NaN
name: time
type: Parameter

173474
constant: true
value: NaN
name: V
type: Parameter

MODEL1201070000
parameter: 173595
rule: 173823
rule: 173787
parameter: 173183
parameter: 173631
parameter: 173195
parameter: 173268
parameter: 173462
compartment: 173111
parameter: 173402
parameter: 173340
parameter: 173474
rule: 173811
parameter: 173607
parameter: 173292
parameter: 173414
parameter: 173377
parameter: 173486
parameter: 173619
parameter: 173559
rule: 173727
parameter: 173571
parameter: 173498
substance units: 163161
parameter: 173316
parameter: 173147
parameter: 173328
parameter: 173159
parameter: 173426
parameter: 173171
parameter: 173643
parameter: 173256
parameter: 173365
parameter: 173438
is described by: http://identifiers.org/pubmed/10388739
parameter: 173655
parameter: 173450
parameter: 173667
notes: This a model from the article: Effect of Na/Ca exchange on plateau fraction and [Ca]i in models for bursting in pancreatic beta-cells. Gall D, Susa I. Biophys J. 1999 Jul;77(1):45-53. 10388739 , Abstract: In the presence of an insulinotropic glucose concentration, beta-cells, in intact pancreatic islets, exhibit periodic bursting electrical activity consisting of an alternation of active and silent phases. The fraction of time spent in the active phase over a period is called the plateau fraction and is correlated with the rate of insulin release. However, the mechanisms that regulate the plateau fraction remain unclear. In this paper we investigate the possible role of the plasma membrane Na+/Ca2+ exchange of the beta-cell in controlling the plateau fraction. We have extended different single-cell models to incorporate this Ca2+-activated electrogenic Ca2+ transporter. We find that the Na+/Ca2+ exchange can provide a physiological mechanism to increase the plateau fraction as the glucose concentration is raised. In addition, we show theoretically that the Na+/Ca2+ exchanger is a key regulator of the cytoplasmic calcium concentration in clusters of heterogeneous cells with gap-junctional electrical coupling. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Gall and Susa(1999)_Model A The original CellML model was created by: Catherine Lloyd c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable,…
curated: false
parameter: 173510
type: SBMLModel
rule: 173739
parameter: 173123
parameter: 173352
rule: 173715
parameter: 173522
parameter: 173135
parameter: 173534
area units: 802883
parameter: 173583
rule: 173691
parameter: 173546
volume units: 122997
rule: 173775
rule: 173751
rule: 173703
length unit: 802859
parameter: 173207
parameter: 173231
name: Gall1999_CalciumBursting_BetaCellModel_A
parameter: 173219
parameter: 173243
rule: 173799
time units: 152087
parameter: 173304
parameter: 173280
parameter: 173679
parameter: 173389
rule: 173763