GENE_ASSOCIATION: NM_002197.1 GENE_LIST: NM_002197.1 SUBSYSTEM: Citrate Cycle (TCA)
carnitine eicosenoyltransferase (C20:1Crn, n11)
GENE_ASSOCIATION: (NM_005956.2 or NM_015440.3) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Vitamins & Cofactor Biosynthesis
formate-tetrahydrofolate ligase, mitochondrial
GENE_ASSOCIATION: NM_001467.3 GENE_LIST: NM_001467.3 SUBSYSTEM: Transport, Endoplasmic Reticular
glucose 6-phosphate endoplasmic reticular transport via diffusion
carnitine pentadecanoyltransferase (C15:0Crn)
fatty-acid--CoA ligase (eicosenoate, C20:1 n-11)
Nicotinamide adenine dinucleotide phosphate
GENE_ASSOCIATION: (NM_018018.2 or NM_007231.1 or NM_018976.3) GENE_LIST: NM_007231.1 NM_018018.2 NM_018976.3 SUBSYSTEM: Transport, Extracellular
L-histidine transport in via sodium symport, blood
octadecadienoyl carnitine (C18:2Crn, n-6)
GENE_ASSOCIATION: NM_006755.1 GENE_LIST: NM_006755.1 SUBSYSTEM: Pentose Phosphate Pathway
phosphatidylglycerol phosphate phosphatase A, mitochondrial, human adipocyte
GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
carnitine eicosatetraenoyltransferase (C20:4Crn, n6), mitochondrial
phosphatidyl-1D-myo-inositol, human adipocyte
carnitine hexadecenoyltransferase (C16:1Crn, n7)
carnitine octadecenoyltransferase (C18:1Crn, n9), mitochondrial
fatty-acid--CoA ligase (octadecadienoate, C18:2 n-6)
GENE_ASSOCIATION: NM_144563.2 GENE_LIST: NM_144563.2 SUBSYSTEM: Pentose Phosphate Pathway
SUBSYSTEM: Transport, Endoplasmic Reticular
malate oxaloacetate shuttle, mitochondrial
3',5'-cyclic-nucleotide phosphodiesterase
carnitine octadecenoyltransferase (C18:1Crn, n5), mitochondrial
carnitine docosapentaenoyltransferase (C22:5Crn, n3)
dodecanoate (C12:0) mammalian cell transport
GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
SUBSYSTEM: Glycine and Serine Metabolism
carnitine hexadecenoyltransferase (C16:1Crn, n9), mitochondrial
GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
octadecadienoyl carnitine transferase (C18:2Crn, n6)
GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: (NM_020244.2 or NM_006090.3 or NM_001007794.1) GENE_LIST: NM_001007794.1 NM_006090.3 NM_020244.2 SUBSYSTEM: Phospholipid Metabolism
diacylglycerol cholinephosphotransferase, human adipocyte
GENE_ASSOCIATION: NM_000373.1 GENE_LIST: NM_000373.1 SUBSYSTEM: Nucleotide Metabolism
eicosanoyl carnitine transport (C20:0Crn)
GENE_ASSOCIATION: NM_000274.1 GENE_LIST: NM_000274.1 SUBSYSTEM: Arginine and Proline Metabolism
This model is from the article: A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. Bordbar A, Feist AM, Usaite-Black R, Woodcock J, Palsson BO, Famili I. BMC Syst Biol. 2011 Oct 31;5(1):180. 22041191 , Abstract: ABSTRACT: BACKGROUND: Genome-scale metabolic reconstructions provide a biologically meaningful mechanis tic basis for the genotype-phenotype relationship. The global human metabolic net work, termed Recon 1, has recently been reconstructed allowing the systems analys is of human metabolic physiology and pathology. Utilizing high-throughput data, R econ 1 has recently been tailored to different cells and tissues, including the l iver, kidney, brain, and alveolar macrophage. These models have shown utility in the study of systems medicine. However, no integrated analysis between human tiss ues has been done. RESULTS: To describe tissue-specific functions, Recon 1 was tailored to describe metabolis m in three human cells: adipocytes, hepatocytes, and myocytes. These cell-specifi c networks were manually curated and validated based on known cellular metabolic functions. To study intercellular interactions, a novel multi-tissue type modelin g approach was developed to integrate the metabolic functions for the three cell types, and subsequently used to simulate known integrated metabolic cycles. In ad dition, the multi-tissue model was used to study diabetes: a pathology with syste mic properties. High-throughput data was integrated with the network to determine differential metabolic activity between obese and type II obese gastric bypass p atients in a whole-body context. CONCLUSION: The multi-tissue type modeling approach presented provides a platform to study in tegrated metabolic states. As more cell and tissue-specific models are released, it is critical to develop a framework in which to study their interdependencies. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
GENE_ASSOCIATION: (NM_003849.1 and NM_003850.1) GENE_LIST: NM_003849.1 NM_003850.1 SUBSYSTEM: Citrate Cycle (TCA)
fatty-acid--CoA ligase (heptadecenoate, C17:1 n-8)
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Asparagine Metabolism
Nicotinamide adenine dinucleotide phosphate - reduced
carnitine tetradecenoyltransferase (C14:1Crn, n5), mitochondrial
alphaketobutyrate transport (mitochondrial)
Squalene epoxidase, endoplasmic reticular
GENE_ASSOCIATION: NM_003129.3 GENE_LIST: NM_003129.3 SUBSYSTEM: Cholesterol Metabolism
fatty-acid--CoA ligase (eicosatetraenoate, C20:4 n-6)
GENE_ASSOCIATION: NM_016368.3 GENE_LIST: NM_016368.3 SUBSYSTEM: Inositol Phosphate Metabolism
GENE_ASSOCIATION: (NM_138733.2 or NM_000291.2) GENE_LIST: NM_000291.2 NM_138733.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
GENE_ASSOCIATION: (NM_014362.2 or NM_198047.1) GENE_LIST: NM_014362.2 NM_198047.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_004577.3 GENE_LIST: NM_004577.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: (NM_003848.1 and NM_003849.1) GENE_LIST: NM_003848.1 NM_003849.1 SUBSYSTEM: Citrate Cycle (TCA)
GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Metabolism
octadecatrienoyl carnitine (C18:3Crn, n3)
eicosadienoyl carnitine transport (C20:2Crn, n6)
fatty-acid--CoA ligase (docosahexaenoate, C22:6 n-3)
fatty-acyl-CoA elongation (C20:4CoA, n3)
Glutamine transport, proton coupled, mitochondria
GENE_ASSOCIATION: (NM_013328.2 or NM_023078.1) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Amino Acid Metabolism
hydrogen peroxide mitochondrial transport
GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotide Metabolism
ribonucleoside-diphosphate reductase (ADP)
Ornithine/citrulline antiport, mitocondiral
GENE_ASSOCIATION: (NM_014252.2 or NM_031947.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
hexadecenoyl carnitinetransport (C16:1Crn, n9)
carnitine octadecatrienoyltransferase (C18:3Crn, n3)
cytochrome P450 lanosterol 14-alpha-demethylase
GENE_ASSOCIATION: NM_000786.2 GENE_LIST: NM_000786.2 SUBSYSTEM: Cholesterol Biosynthesis
eicosatetraenoyl carnitine (C20:4Crn, n-6)
GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Triglycerol Degradation
triacylglycerol hydrolase, human myocyte
Palmitoyl-CoA desaturase (n-C16:0CoA -> C16:1CoA, n-9)
GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Nucleotide Metabolism
carnitine eicosenoyltransferase (C20:1Crn, n11), mitochondrial
phosphoribosylaminoimidazolesuccinocarboxamide synthase
GENE_ASSOCIATION: (NM_152328.3 or NM_199165.1 or NM_001126.2) GENE_LIST: NM_001126.2 NM_152328.3 NM_199165.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: (NM_198324.1 or NM_004077.2) GENE_LIST: NM_004077.2 NM_198324.1 SUBSYSTEM: Citrate Cycle (TCA)
GENE_ASSOCIATION: NM_000454.4 GENE_LIST: NM_000454.4 SUBSYSTEM: Other
Phosphatidylserine synthase 1, human adipocyte
GENE_ASSOCIATION: NM_014754.1 GENE_LIST: NM_014754.1 SUBSYSTEM: Phospholipid Metabolism
3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
alcohol dehydrogenase (ethanol, NADP), forward reaction
GENE_ASSOCIATION: (NM_153326.1 or NM_006066.2) GENE_LIST: NM_006066.2 NM_153326.1 SUBSYSTEM: Cholesterol Metabolism
fatty-acid--CoA ligase (heptadecanoate, C17:0)
docosenoyl carnitine transport (C22:1Crn, n9)
GENE_ASSOCIATION: (NM_058179.2 or NM_021154.3) GENE_LIST: NM_021154.3 NM_058179.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
stearoyl-CoA desaturase (n-C20:0CoA -> C20:1CoA, n-11)
GENE_ASSOCIATION: (NM_005063.4 or NM_024906.1 or NM_001037582.1) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Desaturation
glycine C-acetyltransferase, mitochondrial
GENE_ASSOCIATION: NM_014291.2 GENE_LIST: NM_014291.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
fatty-acid--CoA ligase (docosenoate, C22:1 n-9)
carnitine eicosatetraenoyltransferase (C20:4Crn, n6)
Nicotinamide adenine dinucleotide - reduced
SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
(S)-Methylmalonate semialdehyde transport, mitochondrial
docosapentaenoyl carnitine (C22:5Crn, n-3)
GENE_ASSOCIATION: (NM_000507.2 or NM_003837.2) GENE_LIST: NM_000507.2 NM_003837.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_000859.1 GENE_LIST: NM_000859.1 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: (NM_001003794.1 or NM_007283.5) GENE_LIST: NM_001003794.1 NM_007283.5 SUBSYSTEM: Triglycerol Degradation
monoacylglycerol hydrolase, human adipocyte
L-glutamate reversible transport via proton symport, mitochondrial
GENE_ASSOCIATION: (NM_031481.1 or NM_024698.4) GENE_LIST: NM_024698.4 NM_031481.1 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: NM_000791.3 GENE_LIST: NM_000791.3 SUBSYSTEM: Folate Metabolism
GENE_ASSOCIATION: NM_207315.1 GENE_LIST: NM_207315.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_005518.2 GENE_LIST: NM_005518.2 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Citrate Cycle (TCA)
fatty-acid--CoA ligase (tetradecenoate, C14:1 n-5)
GENE_ASSOCIATION: NM_012088.2 GENE_LIST: NM_012088.2 SUBSYSTEM: Pentose Phosphate Pathway
asparagine synthase (glutamine-hydrolysing)
GENE_ASSOCIATION: (NM_001673.2 or NM_133436.1 or NM_183356.1) GENE_LIST: NM_001673.2 NM_133436.1 NM_183356.1 SUBSYSTEM: Alanine and Aspartate Metabolism
Hydroxymethylglutaryl-CoA reversible mitochondrial transport
fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-6), hepatocyte
GENE_ASSOCIATION: (NM_006721.2 or NM_001123.2) GENE_LIST: NM_001123.2 NM_006721.2 SUBSYSTEM: Nucleotide Metabolism
docosahexaenoyl carnitine transport (C22:6Crn, n3)
carnitine docosahexaenoyltransferase (C22:6Crn, n3)
carnitine octadecanoyltransferase (C18:0Crn), mitochondria
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: (NM_199292.2 or NM_199293.2 or NM_000360.3) GENE_LIST: NM_000360.3 NM_199292.2 NM_199293.2 SUBSYSTEM: Tyrosine metabolism
ocosatetraenoyl carnitine (C22:4Crn, n-6)
eicosatrienoyl carnitine (C20:3Crn, n-6)
GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Biosynthesis
5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
GENE_ASSOCIATION: (NM_004925.3 or NM_001170.1) GENE_LIST: NM_001170.1 NM_004925.3 SUBSYSTEM: Transport, Extracellular
glycerol transport in/out via diffusion reversible
GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Fatty acid activation
GENE_ASSOCIATION: (NM_006133.1 or NM_139179.1) GENE_LIST: NM_006133.1 NM_139179.1 SUBSYSTEM: Triglycerol Degradation
diacylglycerol hydrolase, human adipocyte
GENE_ASSOCIATION: NM_001263.2 GENE_LIST: NM_001263.2 SUBSYSTEM: Phospholipid Metabolism
CDP-Diacylglycerol synthetase, human adipocyte
carnitine octadecenoyltransferase (C18:1Crn, n5)
GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
1-Acyl-sn-glycerol 3-phosphate, adipocyte
GENE_ASSOCIATION: (NM_004508.2 or NM_033261.2) GENE_LIST: NM_004508.2 NM_033261.2 SUBSYSTEM: Cholesterol Metabolism
isopentenyl-diphosphate D-isomerase, peroxisomal
3-hydroxyisobutyrate dehydrogenase, mitochondrial
GENE_ASSOCIATION: NM_152740.2 GENE_LIST: NM_152740.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
alphaketobutyrate dehydrogenase (mitochondrial)
GENE_ASSOCIATION: (NM_019036.1 or NM_001042406.1 or NM_000191.2) GENE_LIST: NM_000191.2 NM_001042406.1 NM_019036.1 SUBSYSTEM: Cholesterol Metabolism
hydroxymethylglutaryl-CoA lyase, mitochondrial
dihydroorotate dehydrogenase (mitochondrial)
GENE_ASSOCIATION: NM_001025193.1 GENE_LIST: NM_001025193.1 SUBSYSTEM: Nucleotide Metabolism
eicosatrienoyl carnitine transport (C20:3Crn, n6)
GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
carnitine eicosadienoyltransferase (C20:2Crn, n6), mitochondrial
glyceraldehyde-3-phosphate dehydrogenase (NAD)
GENE_ASSOCIATION: (NM_014364.3 or NM_002046.3) GENE_LIST: NM_002046.3 NM_014364.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
eicosanoate transport (n-C20:0), cytosol to blood
GENE_ASSOCIATION: NM_001071.1 GENE_LIST: NM_001071.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_014595.1 GENE_LIST: NM_014595.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Tyrosine metabolism
ribonucleoside-diphosphate reductase (UDP)
GENE_ASSOCIATION: (NM_139274.1 or NM_018677.2 or NM_023928.2) GENE_LIST: NM_018677.2 NM_023928.2 NM_139274.1 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: (NM_001098272.1 or NM_002130.4) GENE_LIST: NM_001098272.1 NM_002130.4 SUBSYSTEM: Cholesterol Metabolism
SUBSYSTEM: Vitamins & Cofactor Biosynthesis
GENE_ASSOCIATION: (NM_003748.2 or NM_170726.1) GENE_LIST: NM_003748.2 NM_170726.1 SUBSYSTEM: Arginine and Proline Metabolism
1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
GENE_ASSOCIATION: NM_021095.1 GENE_LIST: NM_021095.1 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: (NM_013328.2 or NM_023078.1) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Proline Metabolism
phosphatidate reversible transport, mitochondrial, adipocyte
cardiolipin reversible transport, mitochondria, adipocyte
octadecatrienoyl carnitine transferase (C18:3Crn, n3)
GENE_ASSOCIATION: (NM_001921.2 or NM_001012732.1) GENE_LIST: NM_001012732.1 NM_001921.2 SUBSYSTEM: Nucleotide Metabolism
fatty-acid--CoA ligase (eicosenoate, C20:1 n-9)
carnitine docosenoyltransferase (C22:1Crn, n9)
diacylglycerol pyrophosphate phosphatase, human adipocyte
GENE_ASSOCIATION: (NM_198830.1 or NM_001096.2) GENE_LIST: NM_001096.2 NM_198830.1 SUBSYSTEM: Central Metabolism
GENE_ASSOCIATION: NM_003124.3 GENE_LIST: NM_003124.3 SUBSYSTEM: Folate Metabolism
GENE_ASSOCIATION: (NM_031432.1 or NM_012474.3) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: (NM_006621.3 or NM_015328.1 or NM_000687.1) GENE_LIST: NM_000687.1 NM_006621.3 NM_015328.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
methylcrotonoyl-CoA carboxylase, mitochondrial
GENE_ASSOCIATION: (NM_020166.2 and NM_022132.3) GENE_LIST: NM_020166.2 NM_022132.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
CO2 transport (diffusion), mitochondrial
Octadecatrienoate (C18:3, n-3) transport
docosahexaenoyl carnitine (C22:6Crn, n-3)
ornithine carbamoyltransferase, mitochondrial
GENE_ASSOCIATION: NM_000531.3 GENE_LIST: NM_000531.3 SUBSYSTEM: Arginine and Proline Metabolism
carnitine docosenoyltransferase (C22:1Crn, n9), mitochondria
fatty-acid--CoA ligase (octadecadienoate, C18:3 n-3), hepatocyte
GENE_ASSOCIATION: (NM_054012.2 or NM_000050.3) GENE_LIST: NM_000050.3 NM_054012.2 SUBSYSTEM: Urea Cycle
GENE_ASSOCIATION: NM_001905.1 GENE_LIST: NM_001905.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
stearoyl-CoA desaturase (n-C22:0CoA -> C22:1CoA, n-9)
formimidoyltetrahydrofolate cyclodeaminase
GENE_ASSOCIATION: (NM_006657.2 or NM_206965.1) GENE_LIST: NM_006657.2 NM_206965.1 SUBSYSTEM: Histidine Degradation
carnitine palmitoyltransferase (C16:0Crn), mitochondrial
fatty-acyl-CoA elongation (C22:5CoA, n3)
GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Nucleotide Metabolism
carnitine pentadecanoyltransferase (C15:0Crn), mitochondria
GENE_ASSOCIATION: NM_000254.1 GENE_LIST: NM_000254.1 SUBSYSTEM: Methionine Metabolism
GENE_ASSOCIATION: (NM_006759.3 or NM_001001521.1) GENE_LIST: NM_001001521.1 NM_006759.3 SUBSYSTEM: Glycogen Metabolism
UTP-glucose-1-phosphate uridylyltransferase
aspartate carbamoyltransferase (reversible)
GENE_ASSOCIATION: NM_003875.2 GENE_LIST: NM_003875.2 SUBSYSTEM: Nucleotide Metabolism
Eicosatetraenoate (C20:4, n-6) transport
GENE_ASSOCIATION: NM_000187.2 GENE_LIST: NM_000187.2 SUBSYSTEM: Tyrosine metabolism
1-Acyl-glycerol-3-phosphate acyltransferase, adipocyte specific
ribonucleoside-diphosphate reductase (CDP)
GENE_ASSOCIATION: NM_012190.2 GENE_LIST: NM_012190.2 SUBSYSTEM: Folate Metabolism
lathosterol oxidase (NAD), endoplasmic reticulum
GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
fatty-acid--CoA ligase (docosanoate, C22:0)
GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Nucleotide Metabolism
carnitine eicosanoyltransferase (C20:0Crn), mitochondria
phosphoribosylformylglycinamidine synthase
GENE_ASSOCIATION: NM_012393.1 GENE_LIST: NM_012393.1 SUBSYSTEM: Nucleotide Metabolism
carnitine O-aceyltransferase, mitochondrial
GENE_ASSOCIATION: (NM_016321.1 or NM_020407.1 or NM_000324.1) GENE_LIST: NM_000324.1 NM_016321.1 NM_020407.1 SUBSYSTEM: Transport, Extracellular
acetyl-CoA C-acetyltransferase, mitochondrial
GENE_ASSOCIATION: NM_000019.2 GENE_LIST: NM_000019.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
L-phenylalanine transport via diffusion (extracellular to cytosol)
GENE_ASSOCIATION: NM_024419.3 GENE_LIST: NM_024419.3 SUBSYSTEM: Phospholipid Metabolism
CDP-diacylglycerol--serine O-phosphatidyltransferae, mitochondrial, human adipoctye
pantetheine-phosphate adenylyltransferase
GENE_ASSOCIATION: NM_001698.1 GENE_LIST: NM_001698.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: ((NM_004863.2 and NM_006415.2) or (NM_004863.2 and NM_178324.1)) GENE_LIST: NM_004863.2 NM_006415.2 NM_178324.1 SUBSYSTEM: Sphingolipid Metabolism
Myristicoyl-CoA desaturase (n-C14:0CoA -> C14:1CoA, n-5)
GENE_ASSOCIATION: (NM_001037582.1 or NM_024906.1 or NM_005063.4) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Desaturation
GENE_ASSOCIATION: NM_001984.1 GENE_LIST: NM_001984.1 SUBSYSTEM: Tyrosine metabolism
L-cysteine reversible transport via sodium symport, reversible, blood
C-3 sterol keto reductase (zymosterol), endoplasmic reticulum
GENE_ASSOCIATION: NM_000320.1 GENE_LIST: NM_000320.1 SUBSYSTEM: Tyrosine metabolism
L-lactate reversible transport via proton symport
GENE_ASSOCIATION: (NM_031947.2 or NM_014252.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
carnitine octadecadienoyltransferase (C18:2Crn, n6)
GENE_ASSOCIATION: NM_001801.2 GENE_LIST: NM_001801.2 SUBSYSTEM: Cysteine Metabolism
Palmitoylcarnitine shuttle (C16:0Crn), mitochondrial
GENE_ASSOCIATION: (NM_004265.2 or NM_021727.3) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Synthesis
stearoyl-CoA desaturase (C18:3CoA, n3 -> C18:4CoA, n3)
glycine passive transport to mitochondria
GENE_ASSOCIATION: NM_000365.4 GENE_LIST: NM_000365.4 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: (NM_000481.2 and NM_000108.3 and NM_004483.3 and NM_000170.1) GENE_LIST: NM_000108.3 NM_000170.1 NM_000481.2 NM_004483.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: NM_130767.2 GENE_LIST: NM_130767.2 SUBSYSTEM: Pyruvate Metabolism
fatty-acid--CoA ligase (eicosadienoate, C20:2 n-6), hepatocyte
Octadecanoate (n-C18:0) transport in via uniport
carnitine eicosanoyltransferase (C20:0Crn)
carnitine O-palmitoyltransferase (C16:0Crn)
alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
GENE_ASSOCIATION: NM_000672.2 GENE_LIST: NM_000672.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: NM_021814.3 GENE_LIST: NM_021814.3 SUBSYSTEM: Fatty acid elongation
fatty-acyl-CoA elongation (n-C20:2CoA, n6)
carnitine tetradecenoyltransferase (C14:1Crn, n5)
carnitine dodecanoyltransferase (C12:0Crn)
Leucine transport, Homo Sapiens mitochondria
GENE_ASSOCIATION: NM_000317.1 GENE_LIST: NM_000317.1 SUBSYSTEM: Folate Metabolism
GENE_ASSOCIATION: NM_003562.3 GENE_LIST: NM_003562.3 SUBSYSTEM: Transport, Mitochondrial
carnitine eicosadienoyltransferase (C20:2Crn, n6)
C-14 sterol reductase, endoplasmic reticulum
GENE_ASSOCIATION: NM_003273.1 GENE_LIST: NM_003273.1 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: (NM_182977.1 or NM_012343.2) GENE_LIST: NM_012343.2 NM_182977.1 SUBSYSTEM: NAD Metabolism
GENE_ASSOCIATION: (NM_001001438.1 or NM_002340.3) GENE_LIST: NM_001001438.1 NM_002340.3 SUBSYSTEM: Cholesterol Metabolism
lanosterol synthase, endoplasmic reticulum
GENE_ASSOCIATION: (NM_199229.1 or NM_006916.1) GENE_LIST: NM_006916.1 NM_199229.1 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_000408.2 or NM_001083112.1) GENE_LIST: NM_000408.2 NM_001083112.1 SUBSYSTEM: Glycerophospholipid Metabolism
glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
octadecenoyl carnitine transport (C18:1Crn, n9)
GENE_ASSOCIATION: NM_021129.3 GENE_LIST: NM_021129.3 SUBSYSTEM: Other
carnitine octadecatrienoyltransferase (C18:3Crn, n3), mitochondrial
phosphate peroxisomal transport via proton symport
L-methionine transport in via sodium symport, blood
methenyltetrahydrofolate cyclohydrolase, mitochondrial
octadecanoyl carnitine transport (C18:0Crn)
Palmitoyl-CoA desaturase (n-C17:0CoA -> C17:1CoA, n-8)
dodecanoyl carnitine transport (C12:0Crn)
fatty-acid--CoA ligase (octadecenoate, C18:1 n-7)
GENE_ASSOCIATION: (NM_000161.2 or NM_001024024.1) GENE_LIST: NM_000161.2 NM_001024024.1 SUBSYSTEM: Tetrahydrobiopterin
GENE_ASSOCIATION: NM_002396.3 GENE_LIST: NM_002396.3 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: NM_005891.1 GENE_LIST: NM_005891.1 SUBSYSTEM: Tryptophan metabolism
bicarbonate transport (Na/HCO3 cotransport), blood
carbonate dehydratase (HCO3 equilibration reaction)
GENE_ASSOCIATION: NM_000071.1 GENE_LIST: NM_000071.1 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: NM_005276.2 GENE_LIST: NM_005276.2 SUBSYSTEM: Glycerophospholipid Metabolism
glycerol-3-phosphate dehydrogenase (NAD)
fatty-acyl-CoA elongation (n-C20:3CoA, n6)
nucleoside-diphosphate kinase (ATP:dADP)
GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-5)
6-Phospho-D-gluconate transport in/out via proton symport
carnitine hexadecenoyltransferase (C16:1Crn, n7), mitochondrial
GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Nucleotides
tetradecanoyl carnitine transport (C14:0Crn)
GENE_ASSOCIATION: NM_000255.1 GENE_LIST: NM_000255.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Synthesis
fatty acyl-CoA desaturase (C20:3CoA, n6 -> C20:4CoA, n6)
stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-7)
GENE_ASSOCIATION: NM_005918.2 GENE_LIST: NM_005918.2 SUBSYSTEM: Citrate Cycle (TCA)
aldehyde dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: (NM_000692.3 or NM_000690.2) GENE_LIST: NM_000690.2 NM_000692.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
L-asparagine transport in via sodium symport, blood
pentadecanoyl carnitine transport (C15:0Crn)
fatty-acid--CoA ligase (dodecanoate, C12:0)
GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Arginine and Proline Metabolism
carnitine eicosatrienoyltransferase (C20:3Crn, n6), mitochondrial
fatty acyl-CoA desaturase (C20:4CoA, n3 -> C20:5CoA, n3)
GENE_ASSOCIATION: NM_004901.1 GENE_LIST: NM_004901.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_006319.3 GENE_LIST: NM_006319.3 SUBSYSTEM: Phospholipid Metabolism
phosphatidylinositol synthase, human adipocyte
HCO3 equilibration reaction, mitochondrial
GENE_ASSOCIATION: (NM_001739.1 or NM_007220.2) GENE_LIST: NM_001739.1 NM_007220.2 SUBSYSTEM: Central Metabolism
fatty-acid--CoA ligase (heptadecanoate, C15:0)
fatty-acid--CoA ligase (octadecenoate, C18:1 n-9)
GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Biosynthesis
fatty-acid--CoA ligase (eicosanoate, C20:0)
Ceramide cholinephosphotransferase, adipocyte
Cholesterol transport, endoplasmic reticulum
phosphate transporter, endoplasmic reticulum
GENE_ASSOCIATION: (NM_006632.3 or NM_001098486.1 or NM_020309.2) GENE_LIST: NM_001098486.1 NM_006632.3 NM_020309.2 SUBSYSTEM: Transport, Endoplasmic Reticular
GENE_ASSOCIATION: NM_014338.3 GENE_LIST: NM_014338.3 SUBSYSTEM: Phospholipid Metabolism
phosphatidylserine decarboxylase, human adipocyte
L-glutamate 5-semialdehyde dehydratase (spontaneous)
carnitine eicosenoyltransferase (C20:1Crn, n9), mitochondrial
GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Cholesterol Metabolism
aldehyde dehydrogenase (acetaldehyde, NAD)
GENE_ASSOCIATION: (NM_018018.2 or NM_005628.1 or NM_003038.2) GENE_LIST: NM_003038.2 NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
6-phosphogluconolactonase, endoplasmic reticulum
GENE_ASSOCIATION: NM_004285.3 GENE_LIST: NM_004285.3 SUBSYSTEM: Pentose Phosphate Pathway
glycine reversible transport via sodium symport, blood
GENE_ASSOCIATION: (NM_005063.4 or NM_001037582.1 or NM_024906.1) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Desaturation
Palmitoyl-CoA desaturase (n-C16:0CoA -> C16:1CoA, n-7)
GENE_ASSOCIATION: NM_000431.1 GENE_LIST: NM_000431.1 SUBSYSTEM: Cholesterol Metabolism
stearoyl-CoA desaturase (n-C20:0CoA -> C20:1CoA, n-9)
GENE_ASSOCIATION: NM_001169.2 GENE_LIST: NM_001169.2 SUBSYSTEM: Cholesterol Metabolism
stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-9), adipocyte
glycerol-3-phosphate transport, mitochondrial
phosphoribosylaminoimidazolecarboxamide formyltransferase
GENE_ASSOCIATION: NM_021823.3 GENE_LIST: NM_021823.3 SUBSYSTEM: CoA Biosynthesis
phosphopantothenoylcysteine decarboxylase
GENE_ASSOCIATION: (NM_032136.3 or NM_001064.1 or NM_012253.2) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
fatty-acid--CoA ligase (docosapentaenoate, C22:5 n-3)
Biomass Demand, Human Adipocyte (biosynthetic GAM)
phosphatidylethanolamine, human adipoctye
GENE_ASSOCIATION: (NM_005415.3 or NM_006749.3) GENE_LIST: NM_005415.3 NM_006749.3 SUBSYSTEM: Transport, Extracellular
phosphate transport in/out via proton symporter
GENE_ASSOCIATION: (NM_000436.2 or NM_022120.1) GENE_LIST: NM_000436.2 NM_022120.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: (NM_000429.2 or (NM_005911.4 and NM_182796.1) or (NM_005911.4 and NM_013283.3)) GENE_LIST: NM_000429.2 NM_005911.4 NM_013283.3 NM_182796.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: (NM_001037811.2 or NM_004493.2) GENE_LIST: NM_001037811.2 NM_004493.2 SUBSYSTEM: Amino Acid Metabolism
3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: (NM_004563.2 or NM_001018073.1) GENE_LIST: NM_001018073.1 NM_004563.2 SUBSYSTEM: Pyruvate Metabolism
Phosphoenolpyruvate carboxykinase (GTP), mitochondrial
sodium transport in/out via proton antiport (one H+), blood
ubiquinol-6 cytochrome c reductase, Complex III
GENE_ASSOCIATION: (NM_005917.2 or NM_001039845.1) GENE_LIST: NM_001039845.1 NM_005917.2 SUBSYSTEM: Citrate Cycle (TCA)
GENE_ASSOCIATION: NM_012145.2 GENE_LIST: NM_012145.2 SUBSYSTEM: Nucleotide Metabolism
cytochrome c oxidase (mitochondrial 4 protons/4 cyto)
GENE_ASSOCIATION: (NM_005309.1 or NM_133443.1) GENE_LIST: NM_005309.1 NM_133443.1 SUBSYSTEM: Alanine and Aspartate Metabolism
octadecenoyl carnitine transferase (C18:1Crn, n7)
fatty-acyl-CoA elongation (C22:4CoA, n6)
lathosterol oxidase (NADP), endoplasmic reticulum
L-leucine transport via diffusion, blood
GENE_ASSOCIATION: (NM_005628.1 or NM_018018.2) GENE_LIST: NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
L-glutamine reversible transport via sodium symport, blood
GENE_ASSOCIATION: NM_015922.1 GENE_LIST: NM_015922.1 SUBSYSTEM: Cholesterol Biosynthesis
C-3 sterol dehydrogenase NADPH, (4-methylzymosterol)
carnitine ocosatetraenoyltransferase (C22:4Crn, n6)
carnitine docosapentaenoyltransferase (C22:5Crn, n3), mitochondrial
ribonucleoside-diphosphate reductase (GDP)
Oleoyl-CoA desaturase (C18:2CoA, n6 -> C18:3CoA, n6)
nucleoside-diphosphate kinase (ATP:dCDP)
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
docosapentaenoyl carnitine transport (C22:5Crn, n3)
GENE_ASSOCIATION: NM_002591.2 GENE_LIST: NM_002591.2 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: (NM_005271.1 or NM_012084.3) GENE_LIST: NM_005271.1 NM_012084.3 SUBSYSTEM: Glutamate Metabolism
glutamate dehydrogenase (NADP), mitochondrial
Valine transport, Homo Sapiens passive diffusion
Phosphatidylglycerophosphate, human adipocyte
eicosenoyl carnitine transport (C20:1Crn, n9)
GENE_ASSOCIATION: NM_002631.2 GENE_LIST: NM_002631.2 SUBSYSTEM: Pentose Phosphate Pathway
methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
GENE_ASSOCIATION: (NM_032136.3 or NM_012253.2 or NM_001064.1) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
GENE_ASSOCIATION: (NM_203391.1 or NM_000167.3 or NM_033214.2) GENE_LIST: NM_000167.3 NM_033214.2 NM_203391.1 SUBSYSTEM: Glycerophospholipid Metabolism
glucose 6-phosphate dehydrogenase, endoplasmic reticulum
2-oxoglutarate dehydrogenase, mitochondrial
L-2-amino-3-oxobutanoate decarboxylation, mitochondrial
SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
L-Glutamate 5-semialdehyde transport, mitochondrial
dimethylallyl diphosphate transport, peroxisome
GENE_ASSOCIATION: (NM_030674.2 or NM_018976.3 or NM_001077484.1) GENE_LIST: NM_001077484.1 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
cardiolipin synthase, mitochondrial adipocyte
SUBSYSTEM: Glycerophospholipid Metabolism
carnitine dodecanoyltransferase (C12:0Crn), mitochondria
GENE_ASSOCIATION: (NM_016308.1 or NM_012145.2) GENE_LIST: NM_012145.2 NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_001159.3 GENE_LIST: NM_001159.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: (NM_001077447.1 or NM_024664.2) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
carbamoyl-phosphate synthase (glutamine-hydrolysing)
eicosatetraenoyl carnitine transport (C20:4Crn, n6)
GENE_ASSOCIATION: NM_032601.2 GENE_LIST: NM_032601.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
methylmalonyl-CoA epimerase, mitochondrial
C-3 sterol dehydrogenase NADH, (4-methylzymosterol)
GENE_ASSOCIATION: (NM_001122633.1 or NM_001122634.1 or NM_001875.2) GENE_LIST: NM_001122633.1 NM_001122634.1 NM_001875.2 SUBSYSTEM: Arginine and Proline Metabolism
GENE_ASSOCIATION: (NM_175085.1 or NM_000819.3) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Nucleotide Metabolism
carnitine eicosatrienoyltransferase (C20:3Crn, n6)
GENE_ASSOCIATION: NM_001752.2 GENE_LIST: NM_001752.2 SUBSYSTEM: Other
CDP-Diacylglycerol synthetase, mitochondrial, human adipocyte
GENE_ASSOCIATION: NM_003818.2 GENE_LIST: NM_003818.2 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: NM_000137.1 GENE_LIST: NM_000137.1 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: NM_004462.3 GENE_LIST: NM_004462.3 SUBSYSTEM: Cholesterol Metabolism
Squalene synthase, endoplasmic reticulum
GENE_ASSOCIATION: (NM_004169.3 or NM_148918.1) GENE_LIST: NM_004169.3 NM_148918.1 SUBSYSTEM: Serine metabolism
acetate mitochondrial transport via proton symport
GENE_ASSOCIATION: NM_002395.2 GENE_LIST: NM_002395.2 SUBSYSTEM: Pyruvate Metabolism
phosphoribosylglycinamide formyltransferase, irreversible
carnitine octadecenoyltransferase (C18:1Crn, n7)
GENE_ASSOCIATION: NM_006623.2 GENE_LIST: NM_006623.2 SUBSYSTEM: Amino Acid Metabolism
carnitine eicosenoyltransferase (C20:1Crn, n9)
L-glutamate 5-semialdehyde dehydratase (spontaneous) mitochondrial
GENE_ASSOCIATION: (NM_213611.1 or NM_005888.2 or NM_002635.2) GENE_LIST: NM_002635.2 NM_005888.2 NM_213611.1 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Amino Acid Metabolism
Propionyl-CoA carboxylase, mitochondrial
GENE_ASSOCIATION: (NM_000282.2 and NM_000532.2) GENE_LIST: NM_000282.2 NM_000532.2 SUBSYSTEM: Phospholipid Metabolism
octadecenoyl carnitine transport (C18:1Crn, n5)
GENE_ASSOCIATION: NM_003627.4 GENE_LIST: NM_003627.4 SUBSYSTEM: Transport, Extracellular
glucose transport, endoplasmic reticulum
Tetradecanoate (n-C14:0) transport in via uniport
GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: NM_002168.2 GENE_LIST: NM_002168.2 SUBSYSTEM: Citrate Cycle (TCA)
carnitine ocosatetraenoyltransferase (C22:4Crn, n6), mitochondrial
L-isoleucine transport via diffusion, blood
phosphoribosylaminoimidazole carboxylase
Nucleoside triphosphate pyrophosphorylase (atp)
carnitine docosahexaenoyltransferase (C22:6Crn, n3), mitochondrial
carnitine octadecanoyltransferase (C18:0Crn)
GENE_ASSOCIATION: (NM_001151.2 or NM_001636.1 or NM_001152.1) GENE_LIST: NM_001151.2 NM_001152.1 NM_001636.1 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_003734.2 GENE_LIST: NM_003734.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
fatty-acid--CoA ligase (hexadecenoate, C16:1 n-9)
nucleoside-diphosphate kinase (ATP:dTDP)
hexadecenoyl carnitine transprot (C16:1Crn, n7)
GENE_ASSOCIATION: (NM_014214.1 or NM_005536.2) GENE_LIST: NM_005536.2 NM_014214.1 SUBSYSTEM: Inositol Phosphate Metabolism
ocosatetraenoyl carnitine transport (C22:4Crn, n6)
GENE_ASSOCIATION: NM_000175.2 GENE_LIST: NM_000175.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: (NM_032564.2 or NM_178176.2 or NM_012079.3) GENE_LIST: NM_012079.3 NM_032564.2 NM_178176.2 SUBSYSTEM: Triacylglycerol Synthesis
triglycerol synthesis, endoplasmic reticulum, adipocyte
GENE_ASSOCIATION: NM_000637.2 GENE_LIST: NM_000637.2 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: NM_005984.1 GENE_LIST: NM_005984.1 SUBSYSTEM: Transport, Mitochondrial
carnitine octadecenoyltransferase (C18:1Crn, n9)
fatty-acid--CoA ligase (hexadecenoate, C16:1 n-7)
glucose transport (uniport: facilitated diffusion)
carnitine hexadecenoyltransferase (C16:1Crn, n9)
tetradecenoyl carnitine transport (C14:1Crn, n5)
fatty acyl-CoA desaturase (C22:5CoA, n3 -> C22:6CoA, n3)
GENE_ASSOCIATION: NM_000277.1 GENE_LIST: NM_000277.1 SUBSYSTEM: Phenylalanine, Tyrosine, and Tryptophan Biosynthesis
GENE_ASSOCIATION: NM_000858.4 GENE_LIST: NM_000858.4 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_005957.3 GENE_LIST: NM_005957.3 SUBSYSTEM: Folate Metabolism
methylenetetrahydrofolate reductase (NADPH2)
C-4 sterol methyl oxidase (4,4-dimethylzymosterol), endoplasmic reticulum
GENE_ASSOCIATION: (NM_001017369.1 or NM_006745.3) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: (NM_032717.3 or NM_020918.2) GENE_LIST: NM_020918.2 NM_032717.3 SUBSYSTEM: Phospholipid Metabolism
glycerol 3-phosphate acyltransferase, adipocyte specific
fatty-acid--CoA ligase (ocosatetraenoate, C22:4 n-6)
GENE_ASSOCIATION: (NM_001042351.1 or NM_000402.2) GENE_LIST: NM_000402.2 NM_001042351.1 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: NM_001098.2 GENE_LIST: NM_001098.2 SUBSYSTEM: Citrate Cycle (TCA)
GENE_ASSOCIATION: (NM_145871.1 or NM_001513.2 or NM_145870.1) GENE_LIST: NM_001513.2 NM_145870.1 NM_145871.1 SUBSYSTEM: Tyrosine metabolism
fatty acid transport via diffusion, blood
isopentenyl diphosphate transport, peroxisome
GENE_ASSOCIATION: NM_018960.4 GENE_LIST: NM_018960.4 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: (NM_033253.2 or NM_001002006.1 or NM_012229.2) GENE_LIST: NM_001002006.1 NM_012229.2 NM_033253.2 SUBSYSTEM: Nucleotide Metabolism
glutamine phosphoribosyldiphosphate amidotransferase
GENE_ASSOCIATION: NM_002703.3 GENE_LIST: NM_002703.3 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
GENE_ASSOCIATION: NM_018677.2 GENE_LIST: NM_018677.2 SUBSYSTEM: Fatty Acid Biosynthesis
GENE_ASSOCIATION: NM_005896.2 GENE_LIST: NM_005896.2 SUBSYSTEM: Citrate Cycle (TCA)
carnitine octadecadienoyltransferase (C18:2Crn, n6), mitochondrial
methylenetetrahydrofolate dehydrogenase (NADP)
carnitine tetradecanoyltransferase (C14:0Crn)
GENE_ASSOCIATION: (NM_002863.3 or NM_002862.3 or NM_005609.1) GENE_LIST: NM_002862.3 NM_002863.3 NM_005609.1 SUBSYSTEM: Glycogen Metabolism
GENE_ASSOCIATION: (NM_003676.2 or NM_144780.1 or NM_206918.1) GENE_LIST: NM_003676.2 NM_144780.1 NM_206918.1 SUBSYSTEM: Phospholipid Metabolism
nucleoside-diphosphate kinase (ATP:dGDP)
S-(hydroxymethyl)glutathione dehydrogenase
GENE_ASSOCIATION: NM_000671.3 GENE_LIST: NM_000671.3 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: (NM_018290.2 or NM_002633.2) GENE_LIST: NM_002633.2 NM_018290.2 SUBSYSTEM: Glycogen Metabolism
glutamate aspartate carrier, cytosolic/mitochondrial
GENE_ASSOCIATION: (NM_014251.2 or NM_003705.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_002035.1 GENE_LIST: NM_002035.1 SUBSYSTEM: Sphingolipid Metabolism
GENE_ASSOCIATION: (NM_004845.3 or NM_005017.2) GENE_LIST: NM_004845.3 NM_005017.2 SUBSYSTEM: Fatty Acid Synthesis
carnitine octadecenoyltransferase (C18:1Crn, n7), mitochondrial
acetate transport in/out via proton symport
inorganic diphosphatase, endoplasmic reticulum
GENE_ASSOCIATION: ((NM_000182.3 and NM_000183.1) or NM_004092.2) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
glutamate dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: (NM_019857.3 or NM_175859.1) GENE_LIST: NM_019857.3 NM_175859.1 SUBSYSTEM: Pyrimidine Biosynthesis
GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial
acetoacetate transport via proton symport, mitochondrial
GENE_ASSOCIATION: (NM_000019.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000019.2 NM_000182.3 NM_000183.1 SUBSYSTEM: Tryptophan metabolism
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Alanine and Aspartate Metabolism
phosphomevalonate kinase, reversible, peroxisome
GENE_ASSOCIATION: NM_006556.2 GENE_LIST: NM_006556.2 SUBSYSTEM: Cholesterol Metabolism
carnitine tetradecanoyltransferase (C14:0Crn, mitochondria
glutamate-5-semialdehyde dehydrogenase, mitochondrial
fatty-acid--CoA ligase (octadecenoate, C18:1 n-5)
eicosenoyl carnitine transport (C20:1Crn, n11)
GENE_ASSOCIATION: (NM_001902.4 or NM_153742.3) GENE_LIST: NM_001902.4 NM_153742.3 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: NM_006636.3 GENE_LIST: NM_006636.3
methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
5,10-Methylenetetrahydrofolate transport, diffusion, mitochondrial
GENE_ASSOCIATION: (NM_014905.2 or NM_013267.2) GENE_LIST: NM_013267.2 NM_014905.2 SUBSYSTEM: Glutamate Metabolism