806473
value: -1000.0
type: LocalParameter

835820
stoichiometry: 1.0
species: 770622
type: SpeciesReference

780790
kinetic law: 780827
product: 780815
reactant: 780803
notes: GENE_ASSOCIATION: NM_002197.1 GENE_LIST: NM_002197.1 SUBSYSTEM: Citrate Cycle (TCA)
fast: false
reversible: true
name: aconitase
type: Reaction

836508
stoichiometry: 2.0
species: 767767
type: SpeciesReference

787030
stoichiometry: 1.0
species: 771492
type: SpeciesReference

851119
value: 1000.0
type: LocalParameter

845621
stoichiometry: 0.001
species: 770973
type: SpeciesReference

809428
stoichiometry: 1.0
species: 767112
type: SpeciesReference

771756
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Isopentenyl diphosphate
type: Species

848385
stoichiometry: 1.0
species: 768800
type: SpeciesReference

791972
product: 792020
kinetic law: 792032
reactant: 791996
fast: false
reversible: true
reactant: 791984
product: 792008
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_001876.2 or NM_152359.1 or NM_004377.2 or NM_001031847.1 or NM_152247.1 or NM_152245.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine eicosenoyltransferase (C20:1Crn, n11)
type: Reaction

815763
stoichiometry: 8.0
species: 770165
type: SpeciesReference

805513
stoichiometry: 1.0
species: 769186
type: SpeciesReference

829149
stoichiometry: 1.0
species: 770357
type: SpeciesReference

814932
value: 500.0
type: LocalParameter

830323
stoichiometry: 1.0
species: 765454
type: SpeciesReference

772708
stoichiometry: 1.63E-4
species: 766883
type: SpeciesReference

789800
stoichiometry: 1.0
species: 770538
type: SpeciesReference

767731
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Oxidized glutathione
type: Species

842502
stoichiometry: 1.0
species: 769609
type: SpeciesReference

849222
stoichiometry: 0.001
species: 768945
type: SpeciesReference

847399
value: 0.0
type: LocalParameter

786591
notes: GENE_ASSOCIATION: (((NM_022745.2 or NM_001042546) and NM_145691.3 and MT4509 and MT4508 and NM_001688.4 and (NM_005176.5 or NM_001002031.2) and (NM_001003785.1 or NM_006356.2) and NM_007100.2 and (NM_004889.2 or NM_001039178.1 or NM_001003714.1 or NM_001003713.1) and (NM_001003703.1 or NM_001003696.1 or NM_001003697.1 or NM_001003701.1 or NM_001685.4) and NM_006476.4 and (NM_015684.2 or NM_001003805.1 or NM_001003803.1) and NM_001697.2 and (NM_004046.4 or NM_001001937.1) and NM_001686.3 and (NM_001001975.1 or NM_001687.4) and (NM_001001977.1 or NM_006886.2) and (NM_005174.2 or NM_001001973.1)) or ((NM_022745.2 or NM_001042546) and NM_145691.3 and MT4509 and MT4508 and NM_001688.4 and (NM_001002027.1 or NM_005175.2) and (NM_001003785.1 or NM_006356.2) and NM_007100.2 and (NM_004889.2 or NM_001039178.1 or NM_001003714.1 or NM_001003713.1) and (NM_001003703.1 or NM_001003696.... GENE_LIST: MT4508 MT4509 NM_001001937.1 NM_001001973.1 NM_001001975.1 NM_001001977.1 NM_001002027.1 NM_001002031.2 NM_001003696.... NM_001003696.1 NM_001003697.1 NM_001003701.1 NM_001003703.1 NM_001003713.1 NM_001003714.1 NM_001003785.1 NM_001003803.1 NM_001003805.1 NM_001039178.1 NM_001042546 NM_001685.4 NM_001686.3 NM_001687.4 NM_001688.4 NM_001697.2 NM_004046.4 NM_004889.2 NM_005174.2 NM_005175.2 NM_005176.5 NM_006356.2 NM_006476.4 NM_006886.2 NM_007100.2 NM_015684.2 NM_022745.2 NM_145691.3 SUBSYSTEM: Oxidative Phosphorylation
reversible: false
fast: false
kinetic law: 786677
product: 786653
product: 786641
reactant: 786616
name: ATP synthase, mitochondrial
reactant: 786628
reactant: 786603
product: 786665
type: Reaction

836666
stoichiometry: 1.0
species: 769198
type: SpeciesReference

813879
stoichiometry: 1.0
species: 770622
type: SpeciesReference

822176
fast: false
product: 822237
notes: GENE_ASSOCIATION: (NM_005956.2 or NM_015440.3) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Vitamins & Cofactor Biosynthesis
reversible: true
name: formate-tetrahydrofolate ligase, mitochondrial
kinetic law: 822261
reactant: 822200
type: Reaction
reactant: 822212
reactant: 822188
product: 822249
product: 822225

816778
stoichiometry: 10.0
species: 769851
type: SpeciesReference

799293
stoichiometry: 1.0
species: 769863
type: SpeciesReference

794044
stoichiometry: 1.0
species: 767138
type: SpeciesReference

850092
stoichiometry: 1.0
species: 768981
type: SpeciesReference

781659
stoichiometry: 2.0
species: 769681
type: SpeciesReference

824084
kinetic law: 824120
product: 824108
reactant: 824096
notes: GENE_ASSOCIATION: NM_001467.3 GENE_LIST: NM_001467.3 SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
type: Reaction

816331
stoichiometry: 9.0
species: 770634
type: SpeciesReference

804243
stoichiometry: 1.0
species: 767355
type: SpeciesReference

813987
value: 1000.0
type: LocalParameter

843689
value: 1000.0
type: LocalParameter

802215
value: -1000.0
type: LocalParameter

842430
value: 1000.0
type: LocalParameter

773447
value: 500.0
type: LocalParameter

794620
value: 0.0
type: LocalParameter

819819
stoichiometry: 1.0
species: 767779
type: SpeciesReference

841354
kinetic law: 841390
product: 841378
reactant: 841366
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: O2 transport in via diffusion
type: Reaction

824650
stoichiometry: 1.0
species: 767767
type: SpeciesReference

804836
stoichiometry: 1.0
species: 771444
type: SpeciesReference

777618
kinetic law: 777655
product: 777643
reactant: 777630
fast: false
reversible: true
name: octadecadienoate (C18:2, n-6) exchange
type: Reaction

807851
stoichiometry: 1.0
species: 766338
type: SpeciesReference

769778
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: CDPdiacylglycerol, human adipocyte
type: Species

846142
stoichiometry: 1.0
species: 771804
type: SpeciesReference

797429
reactant: 797441
notes: GENE_ASSOCIATION: (NM_152359.1 or NM_152245.1 or NM_001031847.1 or NM_152247.1 or NM_001876.2 or NM_004377.2 or NM_152246.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
fast: false
reactant: 797453
product: 797466
kinetic law: 797490
name: carnitine pentadecanoyltransferase (C15:0Crn)
type: Reaction
reversible: true
product: 797478

789631
stoichiometry: 1.0
species: 766556
type: SpeciesReference

816235
stoichiometry: 9.0
species: 769851
type: SpeciesReference

801117
value: 0.0
type: LocalParameter

831539
value: 0.0
type: LocalParameter

792713
stoichiometry: 1.0
species: 766628
type: SpeciesReference

833180
stoichiometry: 1.0
species: 768298
type: SpeciesReference

816669
stoichiometry: 9.0
species: 770165
type: SpeciesReference

775165
value: 1000.0
type: LocalParameter

809536
product: 809609
reactant: 809573
product: 809597
reactant: 809561
reactant: 809548
name: fatty-acid--CoA ligase (eicosenoate, C20:1 n-11)
product: 809585
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203379.1 or NM_001995.2 or NM_004458.1 or NM_203380.1 or NM_004457.3 or NM_022977.1 or NM_016234.3) GENE_LIST: NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
kinetic law: 809621
type: Reaction
reversible: true
fast: false

812325
value: 0.0
type: LocalParameter

797018
value: -1000.0
type: LocalParameter

823651
value: 0.0
type: LocalParameter

785564
value: -1000.0
type: LocalParameter

835290
stoichiometry: 1.0
species: 770985
type: SpeciesReference

846565
value: 0.0
type: LocalParameter

784735
stoichiometry: 1.0
species: 769839
type: SpeciesReference

803008
stoichiometry: 1.0
species: 768323
type: SpeciesReference

776991
value: -1000.0
type: LocalParameter

783500
stoichiometry: 1.0
species: 769839
type: SpeciesReference

815282
value: 0.0
type: LocalParameter

835712
stoichiometry: 1.0
species: 768310
type: SpeciesReference

811249
stoichiometry: 0.159
species: 768458
type: SpeciesReference

845488
value: 0.0
type: LocalParameter

770237
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: GDP
type: Species

779788
stoichiometry: 2.0
species: 769657
type: SpeciesReference

790841
value: -1000.0
type: LocalParameter

817959
stoichiometry: 1.0
species: 770165
type: SpeciesReference

783367
stoichiometry: 1.0
species: 769513
type: SpeciesReference

841573
stoichiometry: 1.0
species: 771780
type: SpeciesReference

775878
kinetic law: 775914
product: 775902
reactant: 775890
fast: false
reversible: true
name: hexadecenoate (C16:1, n-7) exchange
type: Reaction

807635
value: 0.0
type: LocalParameter

831166
stoichiometry: 2.0
species: 768323
type: SpeciesReference

849876
value: 0.0
type: LocalParameter

803893
stoichiometry: 1.0
species: 767767
type: SpeciesReference

831239
value: 1000.0
type: LocalParameter

787984
kinetic law: 788032
product: 788020
product: 788008
reactant: 787996
notes: SUBSYSTEM: Other
fast: false
reversible: false
name: catalase, mitochondrial
type: Reaction

834230
value: 1000.0
type: LocalParameter

779994
value: 0.0
type: LocalParameter

834784
kinetic law: 834820
product: 834808
reactant: 834796
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-lysine transport via diffusion, blood
type: Reaction

844787
value: 0.0
type: LocalParameter

843471
value: 0.0
type: LocalParameter

812059
stoichiometry: 1.0
species: 766604
type: SpeciesReference

780138
value: 0.0
type: LocalParameter

782461
stoichiometry: 0.001
species: 765888
type: SpeciesReference

842844
value: 0.0
type: LocalParameter

832768
stoichiometry: 1.0
species: 770261
type: SpeciesReference

824385
stoichiometry: 1.0
species: 769343
type: SpeciesReference

831803
stoichiometry: 1.0
species: 770441
type: SpeciesReference

786049
value: -1000.0
type: LocalParameter

823543
value: 0.0
type: LocalParameter

792861
stoichiometry: 1.0
species: 769851
type: SpeciesReference

790300
value: 1000.0
type: LocalParameter

823278
value: 1000.0
type: LocalParameter

815498
stoichiometry: 1.0
species: 769851
type: SpeciesReference

810971
value: 0.0
type: LocalParameter

825462
value: 0.0
type: LocalParameter

774717
kinetic law: 774754
product: 774742
reactant: 774730
fast: false
reversible: true
name: eicosatetraenoate (C20:4, n-6) exchange
type: Reaction

853314
value: 0.0
type: LocalParameter

777486
value: 1000.0
type: LocalParameter

793030
value: 1000.0
type: LocalParameter

785987
stoichiometry: 1.0
species: 766300
type: SpeciesReference

770647
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Nicotinamide adenine dinucleotide phosphate
type: Species

844462
stoichiometry: 1.0
species: 767440
type: SpeciesReference

769330
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: UDP
type: Species

787322
stoichiometry: 1.0
species: 771516
type: SpeciesReference

849768
value: 0.0
type: LocalParameter

794416
stoichiometry: 1.0
species: 769863
type: SpeciesReference

813149
stoichiometry: 1.0
species: 770165
type: SpeciesReference

765117
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Acetate
type: Species

778295
kinetic law: 778331
product: 778319
reactant: 778307
fast: false
reversible: true
name: L-Serine exchange
type: Reaction

844570
stoichiometry: 1.0
species: 767392
type: SpeciesReference

831010
reactant: 831034
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_007231.1 or NM_018976.3) GENE_LIST: NM_007231.1 NM_018018.2 NM_018976.3 SUBSYSTEM: Transport, Extracellular
reactant: 831022
name: L-histidine transport in via sodium symport, blood
product: 831058
kinetic law: 831070
product: 831046
type: Reaction
fast: false
reversible: true

771324
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: (S)-Squalene-2,3-epoxide
type: Species

774607
value: 500.0
type: LocalParameter

770756
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecadienoyl carnitine (C18:2Crn, n-6)
type: Species

839652
value: 0.0
type: LocalParameter

785142
value: 1000.0
type: LocalParameter

818902
stoichiometry: 1.0
species: 767779
type: SpeciesReference

802792
stoichiometry: 1.0
species: 768335
type: SpeciesReference

840716
stoichiometry: 1.0
species: 766688
type: SpeciesReference

794560
stoichiometry: 1.0
species: 767900
type: SpeciesReference

830154
value: -1000.0
type: LocalParameter

790733
value: 1000.0
type: LocalParameter

783258
stoichiometry: 1.0
species: 769839
type: SpeciesReference

773555
kinetic law: 773591
product: 773579
reactant: 773567
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

799087
value: 1000.0
type: LocalParameter

792653
value: -1000.0
type: LocalParameter

837732
stoichiometry: 1.0
species: 768250
type: SpeciesReference

853615
kinetic law: 853675
reversible: true
product: 853663
notes: GENE_ASSOCIATION: NM_006755.1 GENE_LIST: NM_006755.1 SUBSYSTEM: Pentose Phosphate Pathway
name: transaldolase
reactant: 853639
product: 853651
fast: false
type: Reaction
reactant: 853627

815173
stoichiometry: 8.0
species: 770622
type: SpeciesReference

810127
stoichiometry: 1.0
species: 766398
type: SpeciesReference

844859
stoichiometry: 1.0
species: 768335
type: SpeciesReference

849028
value: 1000.0
type: LocalParameter

845597
product: 845633
reactant: 845621
kinetic law: 845658
reversible: false
reactant: 845609
product: 845646
fast: false
name: phosphatidylglycerol phosphate phosphatase A, mitochondrial, human adipocyte
type: Reaction
notes: SUBSYSTEM: Phospholipid Metabolism

811358
value: -1000.0
type: LocalParameter

808261
stoichiometry: 1.0
species: 766616
type: SpeciesReference

821766
stoichiometry: 1.0
species: 767767
type: SpeciesReference

832611
stoichiometry: 1.0
species: 770647
type: SpeciesReference

793186
type: Reaction
reactant: 793210
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 793223
reversible: true
name: carnitine eicosatetraenoyltransferase (C20:4Crn, n6), mitochondrial
kinetic law: 793247
fast: false
product: 793235
reactant: 793198

785879
stoichiometry: 1.0
species: 766300
type: SpeciesReference

787876
kinetic law: 787924
product: 787912
product: 787900
reactant: 787888
notes: SUBSYSTEM: Other
fast: false
reversible: false
name: catalase
type: Reaction

830044
value: 1000.0
type: LocalParameter

775465
value: 0.0
type: LocalParameter

853058
value: 0.0
type: LocalParameter

770165
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: FADH2
type: Species

766095
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 6-Phospho-D-gluconate
type: Species

810019
stoichiometry: 1.0
species: 766338
type: SpeciesReference

823121
stoichiometry: 1.0
species: 768310
type: SpeciesReference

768812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: phosphatidyl-1D-myo-inositol, human adipocyte
type: Species

774087
value: 0.0
type: LocalParameter

801975
stoichiometry: 1.0
species: 767779
type: SpeciesReference

792507
stoichiometry: 1.0
species: 770093
type: SpeciesReference

793464
stoichiometry: 1.0
species: 766616
type: SpeciesReference

798107
value: -1000.0
type: LocalParameter

845197
stoichiometry: 1.0
species: 766095
type: SpeciesReference

811502
stoichiometry: 1.0
species: 767215
type: SpeciesReference

845731
stoichiometry: 1.0
species: 768359
type: SpeciesReference

844631
value: 0.0
type: LocalParameter

797707
stoichiometry: 1.0
species: 766628
type: SpeciesReference

837756
value: -1000.0
type: LocalParameter

770019
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: endecanoyl-CoA (C11:0CoA)
type: Species

794152
name: carnitine hexadecenoyltransferase (C16:1Crn, n7)
reactant: 794176
product: 794200
reactant: 794164
kinetic law: 794212
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_001031847.1 or NM_001876.2 or NM_152245.1 or NM_152246.1 or NM_152359.1 or NM_004377.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
product: 794188
type: Reaction
fast: false

774208
value: 0.0
type: LocalParameter

767888
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: hexadecenoyl carnitine (C16:1Crn, n-7)
type: Species

770913
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: propionyl-carnitine
type: Species

854582
value: 0.0
type: LocalParameter

801576
stoichiometry: 1.0
species: 768885
type: SpeciesReference

809838
stoichiometry: 1.0
species: 766398
type: SpeciesReference

765962
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-Dehydrosphinganine
type: Species

773675
stoichiometry: 1.0
species: 771888
type: SpeciesReference

795729
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 795753
reversible: true
name: carnitine octadecenoyltransferase (C18:1Crn, n9), mitochondrial
product: 795777
type: Reaction
product: 795765
fast: false
kinetic law: 795789
reactant: 795741

769923
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: docosenoyl-CoA (C22:1CoA, n-9)
type: Species

777378
value: 0.0
type: LocalParameter

837334
stoichiometry: 1.0
species: 767573
type: SpeciesReference

794778
stoichiometry: 1.0
species: 769863
type: SpeciesReference

852609
stoichiometry: 1.0
species: 771576
type: SpeciesReference

842734
stoichiometry: 1.0
species: 769803
type: SpeciesReference

824493
stoichiometry: 1.0
species: 768800
type: SpeciesReference

799631
stoichiometry: 1.0
species: 770345
type: SpeciesReference

848495
stoichiometry: 1.0
species: 766240
type: SpeciesReference

771600
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Zymosterol
type: Species

806581
value: 1000.0
type: LocalParameter

805926
value: 500.0
type: LocalParameter

851770
stoichiometry: 2.0
species: 768372
type: SpeciesReference

851227
value: 0.0
type: LocalParameter

834674
stoichiometry: 1.0
species: 771540
type: SpeciesReference

849113
stoichiometry: 1.0
species: 767767
type: SpeciesReference

833072
stoichiometry: 1.0
species: 767512
type: SpeciesReference

841463
stoichiometry: 1.0
species: 768359
type: SpeciesReference

796312
value: 0.0
type: LocalParameter

801552
stoichiometry: 0.001
species: 768690
type: SpeciesReference

782811
value: 1000.0
type: LocalParameter

805624
stoichiometry: 1.0
species: 767719
type: SpeciesReference

809101
product: 809162
fast: false
reversible: true
name: fatty-acid--CoA ligase (octadecadienoate, C18:2 n-6)
reactant: 809137
product: 809174
product: 809149
reactant: 809125
type: Reaction
reactant: 809113
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_203372.1 or NM_203379.1 or NM_004458.1 or NM_015256.2 or NM_022977.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
kinetic law: 809186

804134
value: 0.0
type: LocalParameter

813442
reactant: 813503
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1))... GENE_LIST: ... NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 813528
reactant: 813491
reversible: false
product: 813540
kinetic law: 813564
reactant: 813454
reactant: 813466
product: 813552
fast: false
product: 813515
type: Reaction
name: Beta oxidation of fatty acid
reactant: 813479

856299
value: -1000.0
type: LocalParameter

824760
stoichiometry: 0.001
species: 766968
type: SpeciesReference

781502
value: 0.0
type: LocalParameter

826116
stoichiometry: 1.0
species: 770333
type: SpeciesReference

789522
stoichiometry: 1.0
species: 771600
type: SpeciesReference

804547
stoichiometry: 1.0
species: 768359
type: SpeciesReference

769669
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: O-Acetylcarnitine
type: Species

819022
stoichiometry: 6.0
species: 768154
type: SpeciesReference

820035
value: 0.0
type: LocalParameter

768666
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ocosatetraenoyl-CoA (C22:4CoA, n-6)
type: Species

769609
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Acetoacetyl-CoA
type: Species

827005
stoichiometry: 1.0
species: 767633
type: SpeciesReference

818091
stoichiometry: 1.0
species: 770153
type: SpeciesReference

825703
stoichiometry: 1.0
species: 767609
type: SpeciesReference

798806
stoichiometry: 1.0
species: 769149
type: SpeciesReference

834121
value: -1000.0
type: LocalParameter

840873
value: 0.0
type: LocalParameter

827634
stoichiometry: 1.0
species: 767695
type: SpeciesReference

812484
stoichiometry: 1.0
species: 769851
type: SpeciesReference

773337
value: 0.0
type: LocalParameter

810766
stoichiometry: 1.0
species: 768885
type: SpeciesReference

817801
stoichiometry: 1.0
species: 770634
type: SpeciesReference

805476
stoichiometry: 1.0
species: 767767
type: SpeciesReference

829694
value: 0.0
type: LocalParameter

838142
stoichiometry: 1.0
species: 769597
type: SpeciesReference

827780
stoichiometry: 1.0
species: 767683
type: SpeciesReference

850152
value: 500.0
type: LocalParameter

766908
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 6,7-Dihydrobiopterin
type: Species

790409
value: 0.0
type: LocalParameter

767040
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dTDP
type: Species

836243
stoichiometry: 1.0
species: 770659
type: SpeciesReference

778077
value: 0.0
type: LocalParameter

796653
value: -1000.0
type: LocalParameter

836099
stoichiometry: 1.0
species: 766604
type: SpeciesReference

797586
stoichiometry: 1.0
species: 769863
type: SpeciesReference

834458
stoichiometry: 3.0
species: 771516
type: SpeciesReference

803734
stoichiometry: 1.0
species: 768335
type: SpeciesReference

798252
value: 0.0
type: LocalParameter

802576
value: 1000.0
type: LocalParameter

765648
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: octadecenoate (C18:1, n-9)
type: Species

827901
stoichiometry: 1.0
species: 767658
type: SpeciesReference

795945
value: 0.0
type: LocalParameter

775309
stoichiometry: 1.0
species: 765382
type: SpeciesReference

836387
stoichiometry: 1.0
species: 768800
type: SpeciesReference

850913
kinetic law: 850949
product: 850937
reactant: 850925
notes: GENE_ASSOCIATION: NM_144563.2 GENE_LIST: NM_144563.2 SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: true
name: ribose-5-phosphate isomerase
type: Reaction

788577
stoichiometry: 1.0
species: 768359
type: SpeciesReference

830865
value: 0.0
type: LocalParameter

803166
stoichiometry: 1.0
species: 768556
type: SpeciesReference

808369
value: 0.0
type: LocalParameter

768286
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Sodium
type: Species

808681
stoichiometry: 1.0
species: 766398
type: SpeciesReference

792434
value: 0.0
type: LocalParameter

855371
value: 0.0
type: LocalParameter

840171
value: 0.0
type: LocalParameter

811696
stoichiometry: 1.0
species: 767306
type: SpeciesReference

771540
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: O2
type: Species

779365
stoichiometry: 1.0
species: 768274
type: SpeciesReference

813296
stoichiometry: 1.0
species: 770622
type: SpeciesReference

817368
stoichiometry: 1.0
species: 770622
type: SpeciesReference

823879
stoichiometry: 1.0
species: 771528
type: SpeciesReference

819396
stoichiometry: 2.0
species: 768335
type: SpeciesReference

776967
stoichiometry: 1.0
species: 772298
type: SpeciesReference

795511
stoichiometry: 1.0
species: 769863
type: SpeciesReference

808801
value: 0.0
type: LocalParameter

817645
value: 1000.0
type: LocalParameter

821984
kinetic law: 822020
product: 822008
reactant: 821996
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: formate transport via diffusion
type: Reaction

774826
stoichiometry: 1.0
species: 765321
type: SpeciesReference

821839
value: 0.0
type: LocalParameter

798955
value: -1000.0
type: LocalParameter

853483
stoichiometry: 1.0
species: 769851
type: SpeciesReference

847242
stoichiometry: 1.0
species: 771444
type: SpeciesReference

827102
value: 0.0
type: LocalParameter

791333
value: 1000.0
type: LocalParameter

849331
stoichiometry: 1.0
species: 765986
type: SpeciesReference

772920
stoichiometry: 2.0E-6
species: 768812
type: SpeciesReference

778851
value: 0.0
type: LocalParameter

803469
stoichiometry: 1.0
species: 768323
type: SpeciesReference

812628
value: 1000.0
type: LocalParameter

842952
value: 0.0
type: LocalParameter

822297
value: 0.0
type: LocalParameter

846118
stoichiometry: 1.0
species: 768800
type: SpeciesReference

855796
stoichiometry: 1.0
species: 769330
type: SpeciesReference

834338
value: 0.0
type: LocalParameter

808453
stoichiometry: 1.0
species: 768885
type: SpeciesReference

809983
stoichiometry: 1.0
species: 766398
type: SpeciesReference

839095
stoichiometry: 1.0
species: 770659
type: SpeciesReference

797175
value: 0.0
type: LocalParameter

851553
stoichiometry: 1.0
species: 769041
type: SpeciesReference

773893
value: 0.0
type: LocalParameter

804691
stoichiometry: 1.0
species: 768335
type: SpeciesReference

787187
stoichiometry: 1.0
species: 771360
type: SpeciesReference

800442
stoichiometry: 1.0
species: 768347
type: SpeciesReference

765744
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: pentadecanoate (C15:0)
type: Species

776543
value: 500.0
type: LocalParameter

848896
value: 0.0
type: LocalParameter

769210
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Threonine
type: Species

767585
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: N1-(5-Phospho-D-ribosyl)glycinamide
type: Species

835145
reversible: true
product: 835182
notes: SUBSYSTEM: Transport, Mitochondrial
product: 835194
fast: false
name: malate oxaloacetate shuttle, mitochondrial
reactant: 835169
kinetic law: 835206
type: Reaction
reactant: 835157

786483
stoichiometry: 1.0
species: 767779
type: SpeciesReference

825014
stoichiometry: 0.064
species: 769101
type: SpeciesReference

780682
stoichiometry: 1.0
species: 770345
type: SpeciesReference

848275
value: 0.0
type: LocalParameter

816994
stoichiometry: 10.0
species: 770345
type: SpeciesReference

781952
value: 0.0
type: LocalParameter

765261
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Eicosanoate (n-C20:0)
type: Species

807996
stoichiometry: 1.0
species: 766338
type: SpeciesReference

854436
value: 1000.0
type: LocalParameter

809320
stoichiometry: 1.0
species: 768885
type: SpeciesReference

809645
value: 1000.0
type: LocalParameter

794344
value: -1000.0
type: LocalParameter

820388
value: 0.0
type: LocalParameter

788153
value: 0.0
type: LocalParameter

800612
value: 0.0
type: LocalParameter

844029
reversible: false
fast: false
notes: GENE_ASSOCIATION: (NM_000924.2 or NM_002599.1 or NM_006661.1 or NM_005020.1 or NM_000921.3 or NM_002603.1 or NM_018945.3 or NM_000922.2 or NM_001098819.1 or NM_001111307.1 or NM_001098818.1 or NM_001104631.1 or NM_000923.1 or NM_001077358.1 or NM_001111308.1 or NM_001029854.1 or NM_001077197.1 or NM_002604.1 or NM_005019.3 or NM_001003683.1 or NM_001037341.1 or NM_003719.2 or NM_016953.2 or NM_001077196.1 or NM_002605.2 or NM_173454.1 or NM_001029853.1 or NM_001029852.1 or NM_001029851.1 or NM_001037339.1 or NM_001111309.1 or NM_002600.3 or NM_001037340.1 or NM_006202.1 or NM_006203.3) GENE_LIST: NM_000921.3 NM_000922.2 NM_000923.1 NM_000924.2 NM_001003683.1 NM_001029851.1 NM_001029852.1 NM_001029853.1 NM_001029854.1 NM_001037339.1 NM_001037340.1 NM_001037341.1 NM_001077196.1 NM_001077197.1 NM_001077358.1 NM_001098818.1 NM_001098819.1 NM_001104631.1 NM_001111307.1 NM_001111308.1 NM_001111309.1 NM_002599.1 NM_002600.3 NM_002603.1 NM_002604.1 NM_002605.2 NM_003719.2 NM_005019.3 NM_005020.1 NM_006202.1 NM_006203.3 NM_006661.1 NM_016953.2 NM_018945.3 NM_173454.1 SUBSYSTEM: Nucleotide Metabolism
name: 3',5'-cyclic-nucleotide phosphodiesterase
type: Reaction
reactant: 844053
kinetic law: 844089
product: 844065
reactant: 844041
product: 844077

794995
reversible: true
product: 795043
product: 795031
reactant: 795019
type: Reaction
kinetic law: 795055
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine octadecenoyltransferase (C18:1Crn, n5), mitochondrial
reactant: 795007

852719
stoichiometry: 1.0
species: 771600
type: SpeciesReference

831996
value: 0.0
type: LocalParameter

838699
stoichiometry: 1.0
species: 770345
type: SpeciesReference

802071
kinetic law: 802107
product: 802095
reactant: 802083
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: docosenoate (C22:1, n-9) transport
type: Reaction

854001
stoichiometry: 1.0
species: 765780
type: SpeciesReference

765852
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 10-Formyltetrahydrofolate
type: Species

792933
value: 0.0
type: LocalParameter

839954
stoichiometry: 1.0
species: 766398
type: SpeciesReference

819456
stoichiometry: 1.0
species: 767960
type: SpeciesReference

824906
stoichiometry: 0.003
species: 767997
type: SpeciesReference

784312
stoichiometry: 1.0
species: 770574
type: SpeciesReference

801829
stoichiometry: 1.0
species: 768359
type: SpeciesReference

786374
stoichiometry: 1.0
species: 766398
type: SpeciesReference

816016
value: 0.0
type: LocalParameter

781721
value: 0.0
type: LocalParameter

803311
stoichiometry: 1.0
species: 768323
type: SpeciesReference

826957
value: 1000.0
type: LocalParameter

766350
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Arginine
type: Species

841138
stoichiometry: 1.0
species: 766228
type: SpeciesReference

856076
value: 0.0
type: LocalParameter

851662
stoichiometry: 1.0
species: 768286
type: SpeciesReference

812736
stoichiometry: 1.0
species: 769657
type: SpeciesReference

777510
value: 500.0
type: LocalParameter

827210
value: 0.0
type: LocalParameter

791489
reactant: 791513
kinetic law: 791549
name: carnitine docosapentaenoyltransferase (C22:5Crn, n3)
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_001876.2 or NM_152246.1 or NM_004377.2 or NM_152245.1 or NM_001031847.1 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 791537
reversible: true
product: 791525
reactant: 791501
type: Reaction
fast: false

798530
stoichiometry: 1.0
species: 769863
type: SpeciesReference

846989
stoichiometry: 1.0
species: 767767
type: SpeciesReference

820231
value: 0.0
type: LocalParameter

814678
stoichiometry: 8.0
species: 770333
type: SpeciesReference

809211
value: 1000.0
type: LocalParameter

848738
value: 0.0
type: LocalParameter

829366
value: -1000.0
type: LocalParameter

832938
kinetic law: 832974
product: 832962
reactant: 832950
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Isoleucine mitochondrial transport
type: Reaction

788262
stoichiometry: 2.0
species: 766240
type: SpeciesReference

820881
stoichiometry: 0.002
species: 768495
type: SpeciesReference

809754
stoichiometry: 1.0
species: 768885
type: SpeciesReference

770453
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: heptanoyl-CoA (C7:0CoA)
type: Species

826554
stoichiometry: 1.0
species: 770671
type: SpeciesReference

777015
value: 0.0
type: LocalParameter

818310
stoichiometry: 1.0
species: 770622
type: SpeciesReference

830491
notes: GENE_ASSOCIATION: (NM_033508.1 or NM_002115.1 or NM_033500.1 or NM_033507.1 or NM_025130.2 or NM_033497.1 or NM_000188.1 or NM_000189.4 or NM_000162.2 or NM_033496.1 or NM_033498.1) GENE_LIST: NM_000162.2 NM_000188.1 NM_000189.4 NM_002115.1 NM_025130.2 NM_033496.1 NM_033497.1 NM_033498.1 NM_033500.1 NM_033507.1 NM_033508.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
kinetic law: 830563
reactant: 830515
type: Reaction
reactant: 830503
fast: false
reversible: false
product: 830539
product: 830527
product: 830551
name: hexokinase (D-glucose:ATP)

844137
value: 500.0
type: LocalParameter

849657
value: 0.0
type: LocalParameter

802360
kinetic law: 802396
product: 802384
reactant: 802372
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: dodecanoate (C12:0) mammalian cell transport
type: Reaction

771828
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ac_b
type: Species

804982
stoichiometry: 1.0
species: 771528
type: SpeciesReference

782000
stoichiometry: 1.0
species: 768495
type: SpeciesReference

773229
value: 1000.0
type: LocalParameter

852828
stoichiometry: 1.0
species: 771384
type: SpeciesReference

847655
value: 0.0
type: LocalParameter

768556
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoyl-CoA (C18:1CoA, n-5)
type: Species

851335
value: 0.0
type: LocalParameter

831383
value: 1000.0
type: LocalParameter

798554
stoichiometry: 1.0
species: 769851
type: SpeciesReference

780574
stoichiometry: 1.0
species: 766616
type: SpeciesReference

770393
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: hexadecenoyl-CoA (C16:1CoA, n-9)
type: Species

771972
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ecsa_b
type: Species

852500
value: 1000.0
type: LocalParameter

800721
value: 1000.0
type: LocalParameter

768397
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecanoate (n-C18:0)
type: Species

783998
stoichiometry: 1.0
species: 768323
type: SpeciesReference

834012
value: 1000.0
type: LocalParameter

808044
value: -1000.0
type: LocalParameter

848164
stoichiometry: 1.0
species: 769730
type: SpeciesReference

785406
stoichiometry: 1.0
species: 768286
type: SpeciesReference

851879
stoichiometry: 2.0
species: 770333
type: SpeciesReference

819179
reversible: false
product: 819252
product: 819240
reactant: 819216
fast: false
product: 819264
kinetic law: 819300
reactant: 819204
product: 819288
product: 819276
type: Reaction
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 819228
reactant: 819192
name: fatty acid synthase (n-C16:0)

852234
value: 0.0
type: LocalParameter

810610
stoichiometry: 1.0
species: 768666
type: SpeciesReference

805368
stoichiometry: 1.0
species: 766434
type: SpeciesReference

838252
value: 0.0
type: LocalParameter

807707
stoichiometry: 1.0
species: 766338
type: SpeciesReference

820664
stoichiometry: 0.002
species: 766809
type: SpeciesReference

783693
value: 0.0
type: LocalParameter

812374
kinetic law: 812410
product: 812398
reactant: 812386
notes: SUBSYSTEM: Glycine and Serine Metabolism
fast: false
reversible: true
name: formaldehyde transport, peroxisomal
type: Reaction

801273
stoichiometry: 0.001
species: 765864
type: SpeciesReference

826262
value: 0.0
type: LocalParameter

826055
value: 0.0
type: LocalParameter

787756
stoichiometry: 1.0
species: 771540
type: SpeciesReference

842091
stoichiometry: 1.0
species: 768421
type: SpeciesReference

830756
stoichiometry: 1.0
species: 769537
type: SpeciesReference

780355
value: -1000.0
type: LocalParameter

768969
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: pentadecanoate (C15:0)
type: Species

825305
stoichiometry: 1.0
species: 766240
type: SpeciesReference

795401
stoichiometry: 1.0
species: 769851
type: SpeciesReference

817537
stoichiometry: 1.0
species: 770622
type: SpeciesReference

765539
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Leucine
type: Species

828094
stoichiometry: 1.0
species: 767658
type: SpeciesReference

819240
stoichiometry: 1.0
species: 766604
type: SpeciesReference

838711
stoichiometry: 1.0
species: 770550
type: SpeciesReference

848055
stoichiometry: 1.0
species: 766458
type: SpeciesReference

829584
value: 0.0
type: LocalParameter

810826
value: 0.0
type: LocalParameter

774935
stoichiometry: 1.0
species: 772044
type: SpeciesReference

767151
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosadienoate (C20:2, n-6)
type: Species

781092
value: 1000.0
type: LocalParameter

851977
value: 500.0
type: LocalParameter

808152
stoichiometry: 1.0
species: 767876
type: SpeciesReference

772068
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: gln_L_b
type: Species

802684
stoichiometry: 1.0
species: 767864
type: SpeciesReference

828811
stoichiometry: 2.0
species: 767779
type: SpeciesReference

786266
stoichiometry: 1.0
species: 769681
type: SpeciesReference

850804
value: 500.0
type: LocalParameter

852924
value: 0.0
type: LocalParameter

817259
value: 0.0
type: LocalParameter

855262
value: 0.0
type: LocalParameter

778741
value: 1000.0
type: LocalParameter

840062
reversible: true
name: nucleoside-diphosphate kinase (ATP:CDP)
notes: GENE_ASSOCIATION: ((NM_001018137.1 and NM_198175.1) or NM_197972.1 or NM_005793.3 or NM_013330.3 or (NM_000269.2 and NM_001018138.1) or (NM_000269.2 and NM_001018139.1) or (NM_001018138.1 and NM_198175.1) or (NM_001018139.1 and NM_198175.1) or NM_002513.2 or (NM_000269.2 and NM_001018137.1) or (NM_000269.2 and NM_002512.2) or (NM_002512.2 and NM_198175.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotide Metabolism
reactant: 840074
fast: false
type: Reaction
reactant: 840086
product: 840110
product: 840098
kinetic law: 840122

820145
stoichiometry: 1.0
species: 766410
type: SpeciesReference

779569
stoichiometry: 1.0
species: 769851
type: SpeciesReference

843253
stoichiometry: 1.0
species: 770622
type: SpeciesReference

813975
value: 0.0
type: LocalParameter

802227
value: 1000.0
type: LocalParameter

816874
stoichiometry: 10.0
species: 770634
type: SpeciesReference

804231
stoichiometry: 1.0
species: 768359
type: SpeciesReference

854994
stoichiometry: 1.0
species: 766616
type: SpeciesReference

837478
value: 1000.0
type: LocalParameter

781647
stoichiometry: 1.0
species: 769730
type: SpeciesReference

824072
value: 0.0
type: LocalParameter

819710
value: 500.0
type: LocalParameter

794632
reactant: 794656
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 794644
kinetic law: 794692
name: carnitine hexadecenoyltransferase (C16:1Crn, n9), mitochondrial
reversible: true
product: 794668
fast: false
type: Reaction
product: 794680

824662
stoichiometry: 1.0
species: 769198
type: SpeciesReference

796215
reactant: 796239
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 796275
reversible: true
reactant: 796227
product: 796263
product: 796251
fast: false
type: Reaction
name: octadecadienoyl carnitine transferase (C18:2Crn, n6)

773459
kinetic law: 773495
product: 773483
reactant: 773471
fast: false
reversible: true
name: L-Asparagine exchange
type: Reaction

841366
stoichiometry: 1.0
species: 765599
type: SpeciesReference

809308
stoichiometry: 1.0
species: 768520
type: SpeciesReference

789643
stoichiometry: 1.0
species: 766616
type: SpeciesReference

821303
value: 0.0
type: LocalParameter

804824
stoichiometry: 1.0
species: 771372
type: SpeciesReference

801081
value: -1000.0
type: LocalParameter

807863
stoichiometry: 1.0
species: 768825
type: SpeciesReference

777606
value: -1.8070695E-4
type: LocalParameter

781709
value: 0.0
type: LocalParameter

769766
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: CDP
type: Species

806204
kinetic law: 806242
product: 806229
reactant: 806217
notes: GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: true
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
type: Reaction

816657
stoichiometry: 11.0
species: 769657
type: SpeciesReference

833192
stoichiometry: 1.0
species: 767767
type: SpeciesReference

775177
value: 0.0
type: LocalParameter

809524
value: 0.0
type: LocalParameter

816247
stoichiometry: 1.0
species: 770105
type: SpeciesReference

801129
reactant: 801141
reactant: 801153
notes: GENE_ASSOCIATION: (NM_020244.2 or NM_006090.3 or NM_001007794.1) GENE_LIST: NM_001007794.1 NM_006090.3 NM_020244.2 SUBSYSTEM: Phospholipid Metabolism
name: diacylglycerol cholinephosphotransferase, human adipocyte
product: 801165
reversible: false
fast: false
kinetic law: 801201
type: Reaction
product: 801177
product: 801189

792725
stoichiometry: 1.0
species: 767215
type: SpeciesReference

827440
stoichiometry: 1.0
species: 770671
type: SpeciesReference

767440
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Fructose 1,6-bisphosphate
type: Species

771768
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: (R)-Mevalonate
type: Species

791984
stoichiometry: 1.0
species: 766628
type: SpeciesReference

815390
stoichiometry: 5.0
species: 770165
type: SpeciesReference

845633
stoichiometry: 0.001
species: 770961
type: SpeciesReference

806485
value: 1000.0
type: LocalParameter

787042
stoichiometry: 1.0
species: 771276
type: SpeciesReference

851892
stoichiometry: 2.0
species: 770707
type: SpeciesReference

835832
stoichiometry: 1.0
species: 770333
type: SpeciesReference

773772
stoichiometry: 1.0
species: 771900
type: SpeciesReference

830311
stoichiometry: 1.0
species: 767839
type: SpeciesReference

809416
stoichiometry: 1.0
species: 766616
type: SpeciesReference

814944
product: 815029
fast: false
product: 815053
kinetic law: 815065
reversible: false
name: Beta oxidation of fatty acid
reactant: 815005
reactant: 814981
reactant: 814993
reactant: 814956
type: Reaction
reactant: 814968
product: 815017
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 ... GENE_LIST: NM_000018.2 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_001919.2 NM_001919.2... NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 815041

815775
stoichiometry: 9.0
species: 770333
type: SpeciesReference

830599
value: 0.0
type: LocalParameter

805501
stoichiometry: 1.0
species: 768298
type: SpeciesReference

846130
stoichiometry: 1.0
species: 771720
type: SpeciesReference

836654
stoichiometry: 1.0
species: 768178
type: SpeciesReference

791141
stoichiometry: 1.0
species: 766628
type: SpeciesReference

813867
stoichiometry: 1.0
species: 770345
type: SpeciesReference

849210
stoichiometry: 1.0
species: 767767
type: SpeciesReference

843097
product: 843145
type: Reaction
kinetic law: 843157
reversible: true
reactant: 843109
notes: GENE_ASSOCIATION: NM_000373.1 GENE_LIST: NM_000373.1 SUBSYSTEM: Nucleotide Metabolism
product: 843133
reactant: 843121
name: orotate phosphoribosyltransferase
fast: false

782474
stoichiometry: 0.007
species: 766846
type: SpeciesReference

850080
stoichiometry: 1.0
species: 766398
type: SpeciesReference

794032
reactant: 794056
product: 794068
reversible: true
name: eicosanoyl carnitine transport (C20:0Crn)
fast: false
reactant: 794044
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 794092
type: Reaction
product: 794080

822164
value: 0.0
type: LocalParameter

816766
product: 816874
reactant: 816814
reversible: false
kinetic law: 816886
reactant: 816802
reactant: 816778
product: 816838
type: Reaction
product: 816850
name: Beta oxidation of fatty acid
reactant: 816826
fast: false
reactant: 816790
product: 816862
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation

779982
value: 0.0
type: LocalParameter

817380
stoichiometry: 2.0
species: 769657
type: SpeciesReference

834772
value: 500.0
type: LocalParameter

844775
value: 1000.0
type: LocalParameter

814388
type: Reaction
reactant: 814400
fast: false
reversible: false
reactant: 814412
product: 814508
product: 814496
product: 814472
reactant: 814424
name: Beta oxidation of long chain fatty acid
product: 814484
product: 814460
reactant: 814436
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_001037811.2) or (NM_001033859.1 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2... GENE_LIST: NM_000018.2 NM_000018.2... NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 814448
kinetic law: 814520

779002
stoichiometry: 1.0
species: 772552
type: SpeciesReference

789498
value: 0.0
type: LocalParameter

854704
stoichiometry: 1.0
species: 767767
type: SpeciesReference

842856
name: ornithine transaminase, mitochondrial
fast: false
reversible: true
kinetic law: 842916
reactant: 842868
product: 842892
reactant: 842880
product: 842904
notes: GENE_ASSOCIATION: NM_000274.1 GENE_LIST: NM_000274.1 SUBSYSTEM: Arginine and Proline Metabolism
type: Reaction

832756
stoichiometry: 1.0
species: 769585
type: SpeciesReference

773241
value: 0.0
type: LocalParameter

MODEL1111070000
reaction: 822466
species: 767228
reaction: 835386
reaction: 785358
species: 771372
reaction: 805708
species: 770309
species: 768009
species: 770117
reaction: 835929
species: 769815
reaction: 808525
species: 770429
species: 767215
reaction: 776749
reaction: 847703
species: 772177
species: 766434
reaction: 840183
reaction: 787271
species: 766300
species: 768837
species: 768397
reaction: 802924
species: 772044
species: 767670
reaction: 843361
reaction: 818637
reaction: 777040
reaction: 831899
species: 765901
reaction: 855651
reaction: 773169
species: 771082
reaction: 780283
reaction: 854594
reaction: 787138
reaction: 773459
species: 770249
reaction: 844811
reaction: 815679
species: 768058
reaction: 777522
reaction: 788092
reaction: 774619
species: 772226
species: 768178
species: 769367
reaction: 830623
species: 771180
species: 766871
reaction: 810115
species: 769234
species: 765599
reaction: 849439
reaction: 806303
reaction: 792824
reaction: 837708
reaction: 797429
species: 768409
reaction: 778199
reaction: 850913
species: 765333
reaction: 845719
reaction: 810550
species: 770817
reaction: 856128
species: 769790
species: 766131
species: 767960
species: 771396
reaction: 824180
reaction: 807803
reaction: 785612
species: 766083
reaction: 815486
reaction: 846216
reaction: 774135
reaction: 812857
species: 767112

855359
value: 0.0
type: LocalParameter

844474
stoichiometry: 1.0
species: 767767
type: SpeciesReference

854850
stoichiometry: 0.001
species: 769258
type: SpeciesReference

777474
value: 0.0
type: LocalParameter

825450
value: 1000.0
type: LocalParameter

838591
stoichiometry: 1.0
species: 768190
type: SpeciesReference

810983
reactant: 811068
reactant: 811189
reactant: 811201
reactant: 811080
kinetic law: 811346
product: 811321
reactant: 811140
reactant: 811044
reactant: 811019
reactant: 811165
reactant: 811116
reactant: 810995
reactant: 811153
reactant: 811104
reactant: 811225
name: Average fatty acyl-coa, human adipocyte
fast: false
reactant: 811213
reactant: 811128
reactant: 811249
reactant: 811092
product: 811334
product: 811309
reactant: 811273
reactant: 811056
reactant: 811297
reactant: 811007
reactant: 811237
reversible: true
type: Reaction
reactant: 811285
reactant: 811261
notes: GENE_ASSOCIATION: (NM_004457.3 or NM_203379.1 or NM_203372.1 or NM_203380.1 or NM_001995.2 or NM_004458.1 or NM_022977.1 or NM_016234.3) GENE_LIST: NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 811031
reactant: 811177

823531
value: 0.0
type: LocalParameter

853326
reactant: 853363
reactant: 853338
product: 853387
fast: false
product: 853399
name: Succinate--CoA ligase (ADP-forming)
kinetic law: 853411
type: Reaction
notes: GENE_ASSOCIATION: (NM_003849.1 and NM_003850.1) GENE_LIST: NM_003849.1 NM_003850.1 SUBSYSTEM: Citrate Cycle (TCA)
product: 853375
reversible: true
reactant: 853350

848750
value: 0.0
type: LocalParameter

792873
stoichiometry: 1.0
species: 770044
type: SpeciesReference

808381
type: Reaction
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_001995.2 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_203372.1 or NM_203379.1) GENE_LIST: NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reversible: true
fast: false
product: 808441
kinetic law: 808465
name: fatty-acid--CoA ligase (heptadecenoate, C17:1 n-8)
product: 808429
reactant: 808393
product: 808453
reactant: 808417
reactant: 808405

787334
stoichiometry: 1.0
species: 771600
type: SpeciesReference

765309
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: eicosatetraenoate (C20:4, n-6)
type: Species

785975
reactant: 785987
kinetic law: 786036
type: Reaction
fast: false
product: 786012
product: 786024
name: aspartate transaminase
reversible: true
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Asparagine Metabolism
reactant: 786000

770659
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species

793042
value: 0.0
type: LocalParameter

817946
stoichiometry: 1.0
species: 769657
type: SpeciesReference

785576
value: 1000.0
type: LocalParameter

798518
reactant: 798530
product: 798566
reactant: 798542
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
fast: false
reversible: true
kinetic law: 798578
product: 798554
type: Reaction
name: carnitine tetradecenoyltransferase (C14:1Crn, n5), mitochondrial

828607
value: 0.0
type: LocalParameter

846553
value: 0.0
type: LocalParameter

770225
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Fumarate
type: Species

815270
value: 1000.0
type: LocalParameter

835724
stoichiometry: 1.0
species: 768385
type: SpeciesReference

789388
value: 0.0
type: LocalParameter

813704
stoichiometry: 1.0
species: 769657
type: SpeciesReference

831227
value: -1000.0
type: LocalParameter

849888
value: 500.0
type: LocalParameter

833904
value: 500.0
type: LocalParameter

846409
value: -1000.0
type: LocalParameter

834242
value: 0.0
type: LocalParameter

787996
stoichiometry: 2.0
species: 770357
type: SpeciesReference

783355
kinetic law: 783391
product: 783379
reactant: 783367
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: alphaketobutyrate transport (mitochondrial)
type: Reaction

775866
value: 500.0
type: LocalParameter

807647
value: 0.0
type: LocalParameter

847945
value: -1000.0
type: LocalParameter

831154
stoichiometry: 1.0
species: 768202
type: SpeciesReference

768825
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species

793198
stoichiometry: 1.0
species: 769863
type: SpeciesReference

775453
value: 1000.0
type: LocalParameter

830056
value: 0.0
type: LocalParameter

785867
stoichiometry: 1.0
species: 765998
type: SpeciesReference

787888
stoichiometry: 2.0
species: 767791
type: SpeciesReference

808273
stoichiometry: 1.0
species: 767960
type: SpeciesReference

844041
stoichiometry: 1.0
species: 766422
type: SpeciesReference

821754
stoichiometry: 1.0
species: 766604
type: SpeciesReference

779159
value: 0.0
type: LocalParameter

810538
value: 0.0
type: LocalParameter

766083
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-Methyltetrahydrofolate
type: Species

817271
value: 1000.0
type: LocalParameter

810007
stoichiometry: 1.0
species: 767189
type: SpeciesReference

853046
value: 1000.0
type: LocalParameter

770153
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: FAD
type: Species

801987
stoichiometry: 1.0
species: 767088
type: SpeciesReference

821608
stoichiometry: 1.0
species: 767488
type: SpeciesReference

770768
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecatrienoyl-CoA (C18:3CoA, n-3)
type: Species

793476
stoichiometry: 1.0
species: 767319
type: SpeciesReference

832321
reactant: 832346
kinetic law: 832394
product: 832370
fast: false
product: 832382
reversible: false
type: Reaction
name: Isocitrate dehydrogenase (NAD+)
product: 832358
notes: GENE_ASSOCIATION: ((NM_005530.2 and NM_174855.1 and NM_174869.1) or (NM_004135.2 and NM_005530.2 and NM_174855.1) or (NM_004135.2 and NM_005530.2 and NM_174856.1) or (NM_004135.2 and NM_005530.2 and NM_006899.2) or (NM_005530.2 and NM_174856.1 and NM_174869.1) or (NM_005530.2 and NM_006899.2 and NM_174869.1)) GENE_LIST: NM_004135.2 NM_005530.2 NM_006899.2 NM_174855.1 NM_174856.1 NM_174869.1 SUBSYSTEM: Citrate Cycle (TCA)
reactant: 832333

789936
stoichiometry: 1.0
species: 766580
type: SpeciesReference

765418
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: H2O
type: Species

837768
value: 1000.0
type: LocalParameter

770007
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosanoylcarnitine, C20:0crn
type: Species

845185
stoichiometry: 1.0
species: 767779
type: SpeciesReference

798119
value: 1000.0
type: LocalParameter

845743
stoichiometry: 1.0
species: 768788
type: SpeciesReference

778283
value: 500.0
type: LocalParameter

844582
stoichiometry: 1.0
species: 766240
type: SpeciesReference

765105
constant: true
size: NaN
spatial dimensions: 3.0
name: Extrasystem
type: Compartment

784638
value: 0.0
type: LocalParameter

794404
stoichiometry: 1.0
species: 767888
type: SpeciesReference

797890
value: 0.0
type: LocalParameter

834350
value: 0.0
type: LocalParameter

839664
value: 1000.0
type: LocalParameter

785154
value: 0.0
type: LocalParameter

835008
value: 500.0
type: LocalParameter

771312
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 7-Dehydrocholesterol
type: Species

778403
stoichiometry: 1.0
species: 765768
type: SpeciesReference

774619
kinetic law: 774656
product: 774644
reactant: 774631
fast: false
reversible: true
name: eicosatrienoate (C20:3, n-6) exchange
type: Reaction

790721
value: -1000.0
type: LocalParameter

783246
stoichiometry: 1.0
species: 770622
type: SpeciesReference

840704
stoichiometry: 1.0
species: 766240
type: SpeciesReference

830166
value: 1000.0
type: LocalParameter

834868
value: 0.0
type: LocalParameter

773567
stoichiometry: 1.0
species: 765165
type: SpeciesReference

799075
value: -1000.0
type: LocalParameter

788418
stoichiometry: 1.0
species: 770345
type: SpeciesReference

818914
stoichiometry: 2.0
species: 768323
type: SpeciesReference

849016
value: -1000.0
type: LocalParameter

802780
stoichiometry: 1.0
species: 767767
type: SpeciesReference

766204
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Acetyl-CoA
type: Species

815161
stoichiometry: 8.0
species: 770345
type: SpeciesReference

844847
stoichiometry: 1.0
species: 766604
type: SpeciesReference

825171
stoichiometry: 1.0
species: 767658
type: SpeciesReference

852379
type: Reaction
product: 852464
reversible: false
product: 852440
fast: false
product: 852452
reactant: 852404
kinetic law: 852476
reactant: 852391
name: Squalene epoxidase, endoplasmic reticular
reactant: 852416
notes: GENE_ASSOCIATION: NM_003129.3 GENE_LIST: NM_003129.3 SUBSYSTEM: Cholesterol Metabolism
reactant: 852428

835615
value: 0.0
type: LocalParameter

823795
value: 0.0
type: LocalParameter

810115
reactant: 810152
reactant: 810140
product: 810188
product: 810164
fast: false
reversible: true
type: Reaction
kinetic law: 810200
name: fatty-acid--CoA ligase (eicosatetraenoate, C20:4 n-6)
product: 810176
reactant: 810127
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_001009185.1 or NM_016234.3 or NM_203372.1 or NM_203379.1 or NM_203380.1 or NM_015256.2 or NM_004458.1 or NM_022977.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis

853603
value: 0.0
type: LocalParameter

784492
value: 0.0
type: LocalParameter

805612
stoichiometry: 1.0
species: 768082
type: SpeciesReference

796081
value: 0.0
type: LocalParameter

841475
stoichiometry: 1.0
species: 771540
type: SpeciesReference

837321
kinetic law: 837358
product: 837346
reactant: 837334
notes: GENE_ASSOCIATION: NM_016368.3 GENE_LIST: NM_016368.3 SUBSYSTEM: Inositol Phosphate Metabolism
fast: false
reversible: false
name: myo-Inositol-1-phosphate synthase
type: Reaction

796324
value: 0.0
type: LocalParameter

813430
value: 500.0
type: LocalParameter

826103
stoichiometry: 1.0
species: 770249
type: SpeciesReference

799790
stoichiometry: 1.0
species: 769379
type: SpeciesReference

829003
value: 500.0
type: LocalParameter

816548
value: 1000.0
type: LocalParameter

824772
stoichiometry: 0.002
species: 766992
type: SpeciesReference

855940
value: -1000.0
type: LocalParameter

769657
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Acetyl-CoA
type: Species

804559
stoichiometry: 1.0
species: 766968
type: SpeciesReference

789534
stoichiometry: 1.0
species: 771336
type: SpeciesReference

827330
value: 0.0
type: LocalParameter

765974
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-Phospho-D-glycerate
type: Species

800309
stoichiometry: 1.0
species: 771216
type: SpeciesReference

774377
value: 0.0
type: LocalParameter

794140
value: 0.0
type: LocalParameter

773663
stoichiometry: 1.0
species: 765177
type: SpeciesReference

806859
value: -1000.0
type: LocalParameter

845039
reversible: true
notes: GENE_ASSOCIATION: (NM_138733.2 or NM_000291.2) GENE_LIST: NM_000291.2 NM_138733.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
reactant: 845052
reactant: 845064
kinetic law: 845101
fast: false
name: phosphoglycerate kinase
type: Reaction
product: 845088
product: 845076

801564
stoichiometry: 0.001
species: 766482
type: SpeciesReference

767876
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: hexadecenoyl-CoA (C16:1CoA, n-9)
type: Species

854570
value: 0.0
type: LocalParameter

770901
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Phosphatidate, adipocyte
type: Species

835941
stoichiometry: 1.0
species: 770538
type: SpeciesReference

769935
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: docosenoyl carnitine (C22:1Crn, n-9)
type: Species

795717
value: 0.0
type: LocalParameter

842746
stoichiometry: 1.0
species: 770333
type: SpeciesReference

799196
value: -1000.0
type: LocalParameter

851239
value: 0.0
type: LocalParameter

805914
value: 0.0
type: LocalParameter

806593
value: 0.0
type: LocalParameter

834662
stoichiometry: 1.0
species: 771528
type: SpeciesReference

851782
stoichiometry: 1.0
species: 767791
type: SpeciesReference

849101
stoichiometry: 1.0
species: 766338
type: SpeciesReference

799643
stoichiometry: 1.0
species: 770719
type: SpeciesReference

771612
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Zymostenol
type: Species

839362
stoichiometry: 1.0
species: 767767
type: SpeciesReference

820592
value: 0.0
type: LocalParameter

776241
value: 0.0
type: LocalParameter

813001
value: 0.0
type: LocalParameter

798264
value: 0.0
type: LocalParameter

791561
value: -1000.0
type: LocalParameter

802564
value: 0.0
type: LocalParameter

797598
stoichiometry: 1.0
species: 770925
type: SpeciesReference

834446
stoichiometry: 4.0
species: 771456
type: SpeciesReference

843397
stoichiometry: 1.0
species: 768310
type: SpeciesReference

774838
stoichiometry: 1.0
species: 772032
type: SpeciesReference

788565
stoichiometry: 1.0
species: 766652
type: SpeciesReference

830877
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
type: Reaction
reversible: false
product: 830925
kinetic law: 830950
fast: false
product: 830913
reactant: 830901
reactant: 830889
notes: GENE_ASSOCIATION: (NM_014362.2 or NM_198047.1) GENE_LIST: NM_014362.2 NM_198047.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
product: 830938

768298
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Nicotinamide adenine dinucleotide
type: Species

795933
value: 1000.0
type: LocalParameter

837017
stoichiometry: 1.0
species: 768202
type: SpeciesReference

812361
value: 500.0
type: LocalParameter

783851
stoichiometry: 1.0
species: 767331
type: SpeciesReference

850901
value: 0.0
type: LocalParameter

817633
value: 0.0
type: LocalParameter

779377
stoichiometry: 1.0
species: 768347
type: SpeciesReference

822008
stoichiometry: 1.0
species: 771396
type: SpeciesReference

786145
stoichiometry: 1.0
species: 768286
type: SpeciesReference

789208
stoichiometry: 1.0
species: 766518
type: SpeciesReference

775007
kinetic law: 775043
product: 775031
reactant: 775019
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

808693
stoichiometry: 1.0
species: 766616
type: SpeciesReference

823867
stoichiometry: 1.0
species: 771444
type: SpeciesReference

840183
reactant: 840207
product: 840219
reversible: true
kinetic law: 840244
product: 840231
type: Reaction
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
notes: GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Nucleotide Metabolism
reactant: 840195
fast: false

785007
stoichiometry: 1.0
species: 768885
type: SpeciesReference

838855
stoichiometry: 1.0
species: 768335
type: SpeciesReference

792422
value: 1000.0
type: LocalParameter

811684
stoichiometry: 1.0
species: 766616
type: SpeciesReference

780211
stoichiometry: 1.0
species: 770165
type: SpeciesReference

849439
kinetic law: 849501
product: 849477
fast: false
type: Reaction
notes: GENE_ASSOCIATION: NM_004577.3 GENE_LIST: NM_004577.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
reactant: 849452
reactant: 849464
name: phosphoserine phosphatase (L-serine)
product: 849489
reversible: false

855505
value: 0.0
type: LocalParameter

821827
value: 1000.0
type: LocalParameter

795523
stoichiometry: 1.0
species: 766628
type: SpeciesReference

842965
value: 0.0
type: LocalParameter

776955
stoichiometry: 1.0
species: 765587
type: SpeciesReference

821972
value: 0.0
type: LocalParameter

819034
stoichiometry: 12.0
species: 768335
type: SpeciesReference

805489
stoichiometry: 1.0
species: 768310
type: SpeciesReference

768654
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Orotidine 5'-phosphate
type: Species

773349
value: 500.0
type: LocalParameter

827913
stoichiometry: 1.0
species: 768286
type: SpeciesReference

827646
stoichiometry: 1.0
species: 767767
type: SpeciesReference

840861
value: 0.0
type: LocalParameter

828715
value: 0.0
type: LocalParameter

825897
value: 0.0
type: LocalParameter

833492
stoichiometry: 1.0
species: 765406
type: SpeciesReference

827792
stoichiometry: 1.0
species: 767767
type: SpeciesReference

807088
value: 1000.0
type: LocalParameter

850164
reactant: 850188
type: Reaction
reactant: 850176
product: 850200
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Pyruvate Metabolism
fast: false
reversible: false
kinetic law: 850224
product: 850212
name: pyruvate transport, mitochondrial

776809
value: 0.0
type: LocalParameter

810754
stoichiometry: 1.0
species: 767016
type: SpeciesReference

838154
stoichiometry: 1.0
species: 769851
type: SpeciesReference

783790
value: -1000.0
type: LocalParameter

800189
value: 0.0
type: LocalParameter

778065
value: 1000.0
type: LocalParameter

836231
stoichiometry: 1.0
species: 769839
type: SpeciesReference

767052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dTMP
type: Species

832104
kinetic law: 832140
product: 832128
reactant: 832116
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: heptadecenoate (C17:1, n-8) transport
type: Reaction

765635
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: octadecenoate (C18:1, n-7)
type: Species

812471
product: 812580
product: 812592
product: 812544
fast: false
reactant: 812484
notes: GENE_ASSOCIATION: ((NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
product: 812568
reactant: 812496
reactant: 812520
reactant: 812508
name: Beta oxidation of fatty acid
reactant: 812532
type: Reaction
reversible: false
product: 812556
kinetic law: 812604

770598
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: (R)-Methylmalonyl-CoA
type: Species

807984
stoichiometry: 1.0
species: 767839
type: SpeciesReference

854424
value: 0.0
type: LocalParameter

780694
stoichiometry: 1.0
species: 769633
type: SpeciesReference

848287
value: 0.0
type: LocalParameter

816982
stoichiometry: 5.0
species: 770153
type: SpeciesReference

781964
value: 500.0
type: LocalParameter

850381
value: 1000.0
type: LocalParameter

829221
kinetic law: 829258
product: 829245
reactant: 829233
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: H2O2 transport, peroxisomal
type: Reaction

825026
stoichiometry: 0.037
species: 769137
type: SpeciesReference

853471
reactant: 853507
type: Reaction
name: Succinate--CoA ligase (GDP-forming)
product: 853531
product: 853543
fast: false
reactant: 853483
notes: GENE_ASSOCIATION: (NM_003848.1 and NM_003849.1) GENE_LIST: NM_003848.1 NM_003849.1 SUBSYSTEM: Citrate Cycle (TCA)
reversible: true
kinetic law: 853555
product: 853519
reactant: 853495

826811
stoichiometry: 1.0
species: 768885
type: SpeciesReference

776095
stoichiometry: 1.0
species: 772189
type: SpeciesReference

847799
value: 1000.0
type: LocalParameter

809633
value: -1000.0
type: LocalParameter

852706
stoichiometry: 1.0
species: 771528
type: SpeciesReference

823108
stoichiometry: 1.0
species: 767767
type: SpeciesReference

834134
value: 1000.0
type: LocalParameter

800600
value: 1000.0
type: LocalParameter

818878
stoichiometry: 1.0
species: 766604
type: SpeciesReference

854013
stoichiometry: 1.0
species: 768286
type: SpeciesReference

814532
value: 0.0
type: LocalParameter

802083
stoichiometry: 1.0
species: 766784
type: SpeciesReference

820448
stoichiometry: 3.0
species: 767767
type: SpeciesReference

766494
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ceramide, adipocyte
type: Species

851457
value: 0.0
type: LocalParameter

778863
value: 500.0
type: LocalParameter

803457
stoichiometry: 2.0
species: 767779
type: SpeciesReference

781868
stoichiometry: 1.0
species: 766398
type: SpeciesReference

791345
value: 0.0
type: LocalParameter

798967
value: 1000.0
type: LocalParameter

822902
value: 1000.0
type: LocalParameter

853495
stoichiometry: 1.0
species: 770321
type: SpeciesReference

847230
stoichiometry: 1.0
species: 771564
type: SpeciesReference

827114
reactant: 827138
kinetic law: 827174
type: Reaction
name: L-glutamate:Na+ symporter, blood
product: 827150
reversible: true
notes: GENE_ASSOCIATION: (NM_004170.4 or NM_005071.1 or NM_004172.3 or NM_004171.2 or NM_006671.3) GENE_LIST: NM_004170.4 NM_004171.2 NM_004172.3 NM_005071.1 NM_006671.3 SUBSYSTEM: Transport, Extracellular
product: 827162
reactant: 827126
fast: false

795279
stoichiometry: 1.0
species: 766616
type: SpeciesReference

811370
value: 1000.0
type: LocalParameter

797162
value: 0.0
type: LocalParameter

839083
stoichiometry: 1.0
species: 770550
type: SpeciesReference

835157
stoichiometry: 1.0
species: 768385
type: SpeciesReference

846868
stoichiometry: 1.0
species: 768286
type: SpeciesReference

803747
stoichiometry: 1.0
species: 768359
type: SpeciesReference

800044
value: 0.0
type: LocalParameter

787480
stoichiometry: 4.0
species: 771456
type: SpeciesReference

809995
stoichiometry: 1.0
species: 766616
type: SpeciesReference

767719
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Geranyl diphosphate
type: Species

769222
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Thymidine
type: Species

788710
stoichiometry: 1.0
species: 770333
type: SpeciesReference

767597
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: GDP
type: Species

786471
stoichiometry: 1.0
species: 766398
type: SpeciesReference

787199
stoichiometry: 1.0
species: 771528
type: SpeciesReference

765756
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Serine
type: Species

776555
kinetic law: 776592
product: 776579
reactant: 776567
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

809742
stoichiometry: 1.0
species: 767254
type: SpeciesReference

820893
stoichiometry: 0.003
species: 768969
type: SpeciesReference

788868
value: 0.0
type: LocalParameter

816439
stoichiometry: 5.0
species: 770153
type: SpeciesReference

801539
stoichiometry: 1.0
species: 767767
type: SpeciesReference

832926
value: 0.0
type: LocalParameter

788250
stoichiometry: 1.0
species: 767803
type: SpeciesReference

844149
reactant: 844161
fast: false
notes: GENE_ASSOCIATION: (NM_000922.2 or NM_033437.2 or NM_033430.2 or NM_001001577.1 or NM_006661.1 or NM_005019.3 or NM_000924.2 or NM_005020.1 or NM_001083.3 or NM_001001568.1 or NM_001001569.1 or NM_001001572.1 or NM_002606.2 or NM_001001567.1 or NM_001001585.1 or NM_001001580.1 or NM_001001570.1 or NM_001077358.1 or (NM_000283.1 and NM_000440.1 and NM_002601.2 and NM_002602.1 and NM_006204.2) or (NM_000283.1 and NM_000440.1 and NM_002601.2 and NM_006204.2 and NM_006205.1) or NM_001001584.1 or NM_001001581.1 or NM_001001576.1 or NM_001001573.1 or NM_001001575.1 or NM_001001583.1 or NM_001001574.1 or NM_001001579.1 or NM_001001582.1 or NM_001003683.1 or NM_002599.1 or NM_000921.3 or NM_016953.2 or NM_001077196.1 or NM_001001578.1 or NM_001001571.1 or NM_001077197.1) GENE_LIST: NM_000283.1 NM_000440.1 NM_000921.3 NM_000922.2 NM_000924.2 NM_001001567.1 NM_001001568.1 NM_001001569.1 NM_001001570.1 NM_001001571.1 NM_001001572.1 NM_001001573.1 NM_001001574.1 NM_001001575.1 NM_001001576.1 NM_001001577.1 NM_001001578.1 NM_001001579.1 NM_001001580.1 NM_001001581.1 NM_001001582.1 NM_001001583.1 NM_001001584.1 NM_001001585.1 NM_001003683.1 NM_001077196.1 NM_001077197.1 NM_001077358.1 NM_001083.3 NM_002599.1 NM_002601.2 NM_002602.1 NM_002606.2 NM_005019.3 NM_005020.1 NM_006204.2 NM_006205.1 NM_006661.1 NM_016953.2 NM_033430.2 NM_033437.2 SUBSYSTEM: Nucleotide Metabolism
reactant: 844174
name: 3',5'-cyclic-nucleotide phosphodiesterase
reversible: false
type: Reaction
product: 844186
product: 844198
kinetic law: 844210

839191
stoichiometry: 1.0
species: 770634
type: SpeciesReference

770441
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Hydroxymethylglutaryl-CoA
type: Species

806131
stoichiometry: 1.0
species: 767040
type: SpeciesReference

826542
stoichiometry: 1.0
species: 770659
type: SpeciesReference

852816
reversible: false
reactant: 852828
product: 852864
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Metabolism
kinetic law: 852888
name: delta24-sterol reductase
type: Reaction
fast: false
reactant: 852840
product: 852876
reactant: 852852

856089
value: 1000.0
type: LocalParameter

794850
value: 0.0
type: LocalParameter

818769
value: 0.0
type: LocalParameter

854122
stoichiometry: 1.0
species: 769416
type: SpeciesReference

802372
stoichiometry: 1.0
species: 766833
type: SpeciesReference

804994
stoichiometry: 1.0
species: 771348
type: SpeciesReference

780586
stoichiometry: 1.0
species: 767767
type: SpeciesReference

771984
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ecsea11_b
type: Species

770381
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: hexadecenoyl-CoA (C16:1CoA, n-7)
type: Species

777028
value: 0.0
type: LocalParameter

851347
value: 500.0
type: LocalParameter

768544
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecatrienoyl carnitine (C18:3Crn, n3)
type: Species

831371
value: 0.0
type: LocalParameter

798542
stoichiometry: 1.0
species: 771168
type: SpeciesReference

839942
reactant: 839966
notes: GENE_ASSOCIATION: (NM_013330.3 or NM_197972.1 or NM_002513.2 or NM_005793.3 or (NM_000269.2 and NM_002512.2) or (NM_001018138.1 and NM_198175.1) or (NM_002512.2 and NM_198175.1) or (NM_000269.2 and NM_001018138.1) or (NM_000269.2 and NM_001018139.1) or (NM_001018139.1 and NM_198175.1) or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotide Metabolism
kinetic law: 840002
reversible: true
name: nucleoside-diphosphate kinase (ATP:UDP)
reactant: 839954
type: Reaction
fast: false
product: 839978
product: 839990

792945
product: 792993
type: Reaction
kinetic law: 793006
reactant: 792957
reversible: true
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
product: 792981
reactant: 792969
name: eicosadienoyl carnitine transport (C20:2Crn, n6)
fast: false

765864
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 1,2-Diacylglycerol, human adipocyte
type: Species

855699
value: -1000.0
type: LocalParameter

811261
stoichiometry: 0.002
species: 768495
type: SpeciesReference

784324
stoichiometry: 1.0
species: 770634
type: SpeciesReference

811914
stoichiometry: 4.0
species: 768323
type: SpeciesReference

768690
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Phosphatidate, adipocyte
type: Species

778754
value: 0.0
type: LocalParameter

819468
stoichiometry: 2.0
species: 768323
type: SpeciesReference

773990
value: 0.0
type: LocalParameter

826969
value: 0.0
type: LocalParameter

797999
value: 1000.0
type: LocalParameter

777920
stoichiometry: 1.0
species: 765708
type: SpeciesReference

831431
stoichiometry: 1.0
species: 769609
type: SpeciesReference

774220
value: 500.0
type: LocalParameter

795389
stoichiometry: 1.0
species: 770805
type: SpeciesReference

786362
stoichiometry: 1.0
species: 771660
type: SpeciesReference

829379
value: 1000.0
type: LocalParameter

816028
value: 500.0
type: LocalParameter

802888
value: 1000.0
type: LocalParameter

776131
value: 0.0
type: LocalParameter

827222
value: 0.0
type: LocalParameter

796907
value: 1000.0
type: LocalParameter

821520
value: -1000.0
type: LocalParameter

812748
stoichiometry: 1.0
species: 770165
type: SpeciesReference

844991
value: -1000.0
type: LocalParameter

851674
stoichiometry: 1.0
species: 769053
type: SpeciesReference

765527
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Lactate
type: Species

795413
stoichiometry: 1.0
species: 770841
type: SpeciesReference

817525
stoichiometry: 1.0
species: 770345
type: SpeciesReference

832539
value: -1000.0
type: LocalParameter

767164
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosenoate (C20:1, n-11)
type: Species

787744
stoichiometry: 1.0
species: 771516
type: SpeciesReference

830768
stoichiometry: 1.0
species: 770622
type: SpeciesReference

780367
value: 1000.0
type: LocalParameter

766640
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: CTP
type: Species

848067
stoichiometry: 1.0
species: 767767
type: SpeciesReference

810838
name: fatty-acid--CoA ligase (docosahexaenoate, C22:6 n-3)
reversible: true
kinetic law: 810923
reactant: 810862
product: 810887
fast: false
type: Reaction
product: 810911
product: 810899
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203380.1 or NM_015256.2 or NM_004457.3 or NM_203372.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1 or NM_004458.1 or NM_022977.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reactant: 810850
reactant: 810875

797441
stoichiometry: 1.0
species: 766628
type: SpeciesReference

790192
value: -1000.0
type: LocalParameter

829596
value: 0.0
type: LocalParameter

846976
stoichiometry: 1.0
species: 768885
type: SpeciesReference

819252
stoichiometry: 1.0
species: 766616
type: SpeciesReference

828082
kinetic law: 828118
product: 828106
reactant: 828094
notes: SUBSYSTEM: Glycine and Serine Metabolism
fast: false
reversible: true
name: glycine transport, peroxisomal
type: Reaction

802672
stoichiometry: 2.0
species: 767779
type: SpeciesReference

808164
stoichiometry: 1.0
species: 768885
type: SpeciesReference

772056
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: glc_D_b
type: Species

811092
stoichiometry: 0.002
species: 767164
type: SpeciesReference

779220
stoichiometry: 1.0
species: 766095
type: SpeciesReference

843241
stoichiometry: 2.0
species: 770345
type: SpeciesReference

851965
value: 0.0
type: LocalParameter

840074
stoichiometry: 1.0
species: 766398
type: SpeciesReference

782691
stoichiometry: 0.002
species: 768666
type: SpeciesReference

815053
stoichiometry: 8.0
species: 770634
type: SpeciesReference

834554
stoichiometry: 1.0
species: 771468
type: SpeciesReference

855250
value: 1000.0
type: LocalParameter

820133
stoichiometry: 2.0
species: 768335
type: SpeciesReference

853759
stoichiometry: 1.0
species: 770634
type: SpeciesReference

811793
reversible: false
reactant: 811841
type: Reaction
product: 811877
product: 811902
notes: SUBSYSTEM: Fatty Acid Synthesis
reactant: 811817
fast: false
reactant: 811805
product: 811865
reactant: 811829
product: 811889
product: 811914
kinetic law: 811927
reactant: 811853
name: fatty-acyl-CoA elongation (C20:4CoA, n3)

852936
value: 500.0
type: LocalParameter

849552
value: 500.0
type: LocalParameter

790048
stoichiometry: 0.001
species: 769815
type: SpeciesReference

786254
stoichiometry: 1.0
species: 766398
type: SpeciesReference

808056
value: 1000.0
type: LocalParameter

845307
stoichiometry: 1.0
species: 771456
type: SpeciesReference

838264
value: 500.0
type: LocalParameter

848176
stoichiometry: 1.0
species: 769851
type: SpeciesReference

834024
value: 0.0
type: LocalParameter

784059
value: 0.0
type: LocalParameter

852222
value: 0.0
type: LocalParameter

820676
stoichiometry: 0.007
species: 766833
type: SpeciesReference

807719
stoichiometry: 1.0
species: 768739
type: SpeciesReference

813589
value: 1000.0
type: LocalParameter

796750
stoichiometry: 1.0
species: 768678
type: SpeciesReference

793259
value: -1000.0
type: LocalParameter

772298
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: nh4_b
type: Species

783681
value: 1000.0
type: LocalParameter

835507
value: 1000.0
type: LocalParameter

828190
stoichiometry: 1.0
species: 766398
type: SpeciesReference

826067
reactant: 826091
product: 826103
product: 826116
kinetic law: 826128
fast: false
reversible: true
name: Glutamine transport, proton coupled, mitochondria
type: Reaction
reactant: 826079
notes: SUBSYSTEM: Transport, Mitochondrial

801285
stoichiometry: 1.0
species: 767779
type: SpeciesReference

841788
stoichiometry: 1.0
species: 769803
type: SpeciesReference

801841
stoichiometry: 0.001
species: 766494
type: SpeciesReference

783524
stoichiometry: 1.0
species: 771132
type: SpeciesReference

828619
value: 500.0
type: LocalParameter

767016
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosapentaenoyl-CoA (C22:5CoA, n-3)
type: Species

800747
value: 0.0
type: LocalParameter

837600
value: 0.0
type: LocalParameter

823675
value: 0.0
type: LocalParameter

836219
stoichiometry: 1.0
species: 770647
type: SpeciesReference

840849
value: 1000.0
type: LocalParameter

798506
value: 0.0
type: LocalParameter

846541
value: 1000.0
type: LocalParameter

825293
stoichiometry: 1.0
species: 767707
type: SpeciesReference

773422
value: 1000.0
type: LocalParameter

831142
stoichiometry: 1.0
species: 766616
type: SpeciesReference

794548
stoichiometry: 1.0
species: 766616
type: SpeciesReference

833916
product: 833976
type: Reaction
reversible: true
reactant: 833940
product: 833952
notes: GENE_ASSOCIATION: ((NM_002300.3 and NM_005566.1) or NM_005566.1 or NM_144972.3 or NM_033195.1 or NM_002300.3 or NM_002301.2 or NM_017448.1 or NM_018314.2) GENE_LIST: NM_002300.3 NM_002301.2 NM_005566.1 NM_017448.1 NM_018314.2 NM_033195.1 NM_144972.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 833964
reactant: 833928
name: L-lactate dehydrogenase
fast: false
kinetic law: 833988

773361
kinetic law: 773398
product: 773385
reactant: 773373
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

785274
stoichiometry: 1.0
species: 767767
type: SpeciesReference

828290
stoichiometry: 1.0
species: 768885
type: SpeciesReference

834892
stoichiometry: 1.0
species: 767779
type: SpeciesReference

789376
value: 1000.0
type: LocalParameter

811225
stoichiometry: 0.393
species: 768433
type: SpeciesReference

807611
value: -1000.0
type: LocalParameter

819987
stoichiometry: 1.0
species: 766760
type: SpeciesReference

832744
stoichiometry: 1.0
species: 770501
type: SpeciesReference

812035
stoichiometry: 4.0
species: 768335
type: SpeciesReference

780114
value: 0.0
type: LocalParameter

842868
stoichiometry: 1.0
species: 769693
type: SpeciesReference

831827
stoichiometry: 1.0
species: 769657
type: SpeciesReference

810417
stoichiometry: 1.0
species: 766398
type: SpeciesReference

854716
stoichiometry: 1.0
species: 768335
type: SpeciesReference

824204
stoichiometry: 1.0
species: 767767
type: SpeciesReference

817392
stoichiometry: 1.0
species: 770165
type: SpeciesReference

844763
value: -1000.0
type: LocalParameter

806885
value: 0.0
type: LocalParameter

843495
notes: GENE_ASSOCIATION: (NM_013328.2 or NM_023078.1) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Amino Acid Metabolism
product: 843544
reactant: 843532
fast: false
product: 843557
name: pyrroline-5-carboxylate reductase
type: Reaction
reversible: false
kinetic law: 843569
reactant: 843507
reactant: 843519

770032
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosadienoyl-CoA (C20:2CoA, n-6)
type: Species

765442
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: hexadecanoate (n-C16:0)
type: Species

793054
value: 0.0
type: LocalParameter

793597
stoichiometry: 1.0
species: 770117
type: SpeciesReference

808393
stoichiometry: 1.0
species: 766398
type: SpeciesReference

821632
stoichiometry: 1.0
species: 767767
type: SpeciesReference

844161
stoichiometry: 1.0
species: 766506
type: SpeciesReference

853338
stoichiometry: 1.0
species: 769730
type: SpeciesReference

812349
value: 0.0
type: LocalParameter

839520
value: 0.0
type: LocalParameter

770622
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Nicotinamide adenine dinucleotide
type: Species

845064
stoichiometry: 1.0
species: 766240
type: SpeciesReference

815787
stoichiometry: 9.0
species: 770634
type: SpeciesReference

829125
kinetic law: 829161
product: 829149
reactant: 829137
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: hydrogen peroxide mitochondrial transport
type: Reaction

814206
type: Reaction
reversible: false
kinetic law: 814327
fast: false
product: 814279
product: 814291
reactant: 814266
reactant: 814254
product: 814303
reactant: 814218
name: Beta oxidation of fatty acid
reactant: 814242
reactant: 814230
product: 814315
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_001608.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_00409... GENE_LIST: NM_000016.2 NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_001919.2 NM_00409... NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation

826981
value: 0.0
type: LocalParameter

774498
value: 0.0
type: LocalParameter

809404
stoichiometry: 1.0
species: 766398
type: SpeciesReference

767755
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: GTP
type: Species

846167
value: -1000.0
type: LocalParameter

804679
stoichiometry: 1.0
species: 767767
type: SpeciesReference

848361
stoichiometry: 1.0
species: 767585
type: SpeciesReference

771732
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: H2O
type: Species

791683
value: -1000.0
type: LocalParameter

822152
value: 0.0
type: LocalParameter

782486
stoichiometry: 0.001
species: 766968
type: SpeciesReference

771107
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Stearoylcarnitine (C18:0Crn)
type: Species

824360
stoichiometry: 1.0
species: 769379
type: SpeciesReference

816754
value: 500.0
type: LocalParameter

843085
value: 0.0
type: LocalParameter

806737
stoichiometry: 1.0
species: 767112
type: SpeciesReference

794020
value: 0.0
type: LocalParameter

849246
stoichiometry: 0.001
species: 768763
type: SpeciesReference

804268
stoichiometry: 1.0
species: 768298
type: SpeciesReference

792738
stoichiometry: 1.0
species: 766616
type: SpeciesReference

820472
stoichiometry: 1.0
species: 768154
type: SpeciesReference

841330
value: 0.0
type: LocalParameter

806217
stoichiometry: 1.0
species: 771612
type: SpeciesReference

794644
stoichiometry: 1.0
species: 769863
type: SpeciesReference

837466
value: 0.0
type: LocalParameter

834590
value: 1000.0
type: LocalParameter

802059
value: 500.0
type: LocalParameter

768118
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Leucine
type: Species

824060
value: 0.0
type: LocalParameter

816211
value: 500.0
type: LocalParameter

765249
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: dodecanoate (C12:0)
type: Species

812301
stoichiometry: 4.0
species: 768323
type: SpeciesReference

775189
value: 500.0
type: LocalParameter

781635
stoichiometry: 1.0
species: 769706
type: SpeciesReference

833059
stoichiometry: 1.0
species: 768058
type: SpeciesReference

804812
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Metabolism
product: 804873
product: 804860
reactant: 804824
fast: false
kinetic law: 804885
reactant: 804836
reactant: 804848
name: 7-dehydrocholesterol reductase

821315
value: 1000.0
type: LocalParameter

789655
stoichiometry: 1.0
species: 766204
type: SpeciesReference

850284
fast: false
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotide Metabolism
product: 850332
type: Reaction
reversible: false
product: 850345
name: ribonucleoside-diphosphate reductase (ADP)
product: 850320
kinetic law: 850357
reactant: 850308
reactant: 850296

801093
value: 1000.0
type: LocalParameter

777799
value: 500.0
type: LocalParameter

795705
value: 0.0
type: LocalParameter

777209
value: 0.0
type: LocalParameter

777354
stoichiometry: 1.0
species: 772346
type: SpeciesReference

835953
stoichiometry: 1.0
species: 770622
type: SpeciesReference

773651
kinetic law: 773687
product: 773675
reactant: 773663
fast: false
reversible: true
name: Choline exchange
type: Reaction

787612
stoichiometry: 1.0
species: 771360
type: SpeciesReference

767864
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: hexadecenoyl-CoA (C16:1CoA, n-7)
type: Species

794176
stoichiometry: 1.0
species: 767864
type: SpeciesReference

815896
stoichiometry: 8.0
species: 770153
type: SpeciesReference

822490
stoichiometry: 1.0
species: 767779
type: SpeciesReference

831407
value: 500.0
type: LocalParameter

796495
stoichiometry: 1.0
species: 769851
type: SpeciesReference

774389
value: 1000.0
type: LocalParameter

771624
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: (R)-5-Diphosphomevalonate
type: Species

839398
value: 1000.0
type: LocalParameter

805792
value: 0.0
type: LocalParameter

769621
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Aminoacetone
type: Species

820580
value: 1000.0
type: LocalParameter

830455
value: 1000.0
type: LocalParameter

842710
product: 842771
reactant: 842734
reactant: 842722
name: Ornithine/citrulline antiport, mitocondiral
reactant: 842746
type: Reaction
reversible: true
fast: false
kinetic law: 842796
product: 842758
product: 842784
notes: GENE_ASSOCIATION: (NM_014252.2 or NM_031947.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial

834650
stoichiometry: 1.0
species: 771444
type: SpeciesReference

794754
fast: false
reactant: 794766
product: 794790
kinetic law: 794814
reactant: 794778
product: 794802
name: hexadecenoyl carnitinetransport (C16:1Crn, n9)
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle

786579
value: 500.0
type: LocalParameter

816100
stoichiometry: 9.0
species: 770622
type: SpeciesReference

792848
stoichiometry: 1.0
species: 770032
type: SpeciesReference

847109
stoichiometry: 1.0
species: 767767
type: SpeciesReference

774730
stoichiometry: 1.0
species: 765309
type: SpeciesReference

813854
stoichiometry: 1.0
species: 770153
type: SpeciesReference

804110
stoichiometry: 1.0
species: 768323
type: SpeciesReference

816464
stoichiometry: 9.0
species: 770622
type: SpeciesReference

781526
stoichiometry: 1.0
species: 766338
type: SpeciesReference

819831
stoichiometry: 2.0
species: 768323
type: SpeciesReference

770369
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Bicarbonate
type: Species

775297
kinetic law: 775333
product: 775321
reactant: 775309
fast: false
reversible: true
name: Glycine exchange
type: Reaction

796336
reactant: 796361
reactant: 796348
kinetic law: 796398
fast: false
reversible: true
product: 796386
product: 796374
name: carnitine octadecatrienoyltransferase (C18:3Crn, n3)
type: Reaction
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152246.1 or NM_152247.1 or NM_152359.1 or NM_001876.2 or NM_001031847.1 or NM_004377.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle

822044
value: 1000.0
type: LocalParameter

809125
stoichiometry: 1.0
species: 766616
type: SpeciesReference

837041
value: -1000.0
type: LocalParameter

852852
stoichiometry: 1.0
species: 771528
type: SpeciesReference

804703
stoichiometry: 1.0
species: 768359
type: SpeciesReference

842637
stoichiometry: 1.0
species: 769355
type: SpeciesReference

855952
value: 1000.0
type: LocalParameter

824784
stoichiometry: 0.002
species: 767016
type: SpeciesReference

769645
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Acetoacetate
type: Species

855093
kinetic law: 855129
product: 855117
reactant: 855105
notes: GENE_ASSOCIATION: (NM_182728.1 or NM_018593.3 or NM_012244.2 or NM_003486.5) GENE_LIST: NM_003486.5 NM_012244.2 NM_018593.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-tryptophan transport, blood
type: Reaction

816536
value: 0.0
type: LocalParameter

820796
stoichiometry: 0.003
species: 767972
type: SpeciesReference

830479
value: 0.0
type: LocalParameter

829015
kinetic law: 829064
product: 829052
product: 829040
reactant: 829028
notes: GENE_ASSOCIATION: (NM_000906.2 or NM_003995.3 or NM_000180.1 or (NM_000856.2 and NM_000857.1) or (NM_000855.1 and NM_000857.1) or NM_004963.1 or NM_001522.1) GENE_LIST: NM_000180.1 NM_000855.1 NM_000856.2 NM_000857.1 NM_000906.2 NM_001522.1 NM_003995.3 NM_004963.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: false
name: guanylate cyclase
type: Reaction

800007
stoichiometry: 2.0
species: 767767
type: SpeciesReference

771300
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 6-phospho-D-glucono-1,5-lactone
type: Species

851529
stoichiometry: 1.0
species: 765756
type: SpeciesReference

842928
value: -1000.0
type: LocalParameter

785166
value: 0.0
type: LocalParameter

849744
value: -1000.0
type: LocalParameter

787456
stoichiometry: 3.0
species: 771540
type: SpeciesReference

834362
product: 834458
type: Reaction
name: cytochrome P450 lanosterol 14-alpha-demethylase
reactant: 834410
reactant: 834374
product: 834434
product: 834446
kinetic law: 834470
notes: GENE_ASSOCIATION: NM_000786.2 GENE_LIST: NM_000786.2 SUBSYSTEM: Cholesterol Biosynthesis
reactant: 834398
fast: false
reversible: false
reactant: 834386
product: 834422

793271
value: 1000.0
type: LocalParameter

831034
stoichiometry: 1.0
species: 765575
type: SpeciesReference

823783
value: 1000.0
type: LocalParameter

785430
value: -1000.0
type: LocalParameter

825183
stoichiometry: 1.0
species: 767779
type: SpeciesReference

788406
stoichiometry: 1.0
species: 769839
type: SpeciesReference

783234
stoichiometry: 1.0
species: 769851
type: SpeciesReference

846433
value: 0.0
type: LocalParameter

817971
stoichiometry: 1.0
species: 770333
type: SpeciesReference

830178
value: 0.0
type: LocalParameter

771528
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species

773579
stoichiometry: 1.0
species: 771876
type: SpeciesReference

770141
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosatetraenoyl carnitine (C20:4Crn, n-6)
type: Species

810526
value: 0.0
type: LocalParameter

779123
stoichiometry: 1.0
species: 768323
type: SpeciesReference

772080
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: glu_L_b
type: Species

811527
stoichiometry: 4.0
species: 768323
type: SpeciesReference

793695
stoichiometry: 1.0
species: 769863
type: SpeciesReference

787852
value: 0.0
type: LocalParameter

850598
stoichiometry: 1.0
species: 767779
type: SpeciesReference

781928
value: 0.0
type: LocalParameter

832635
stoichiometry: 1.0
species: 769839
type: SpeciesReference

821742
stoichiometry: 1.0
species: 768323
type: SpeciesReference

793162
value: 0.0
type: LocalParameter

785855
type: Reaction
reactant: 785879
reversible: false
product: 785903
product: 785891
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Asparagine Metabolism
reactant: 785867
fast: false
name: aspartate transaminase
kinetic law: 785915

775441
value: 0.0
type: LocalParameter

807503
value: 0.0
type: LocalParameter

782594
stoichiometry: 0.03
species: 767864
type: SpeciesReference

855238
value: -1000.0
type: LocalParameter

844595
stoichiometry: 1.0
species: 767380
type: SpeciesReference

844655
value: 0.0
type: LocalParameter

836909
stoichiometry: 1.0
species: 771648
type: SpeciesReference

845173
stoichiometry: 1.0
species: 766107
type: SpeciesReference

845755
stoichiometry: 1.0
species: 769186
type: SpeciesReference

823410
value: 0.0
type: LocalParameter

853447
value: 0.0
type: LocalParameter

790433
kinetic law: 790469
product: 790457
reactant: 790445
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: CO2 peroxisomal transport
type: Reaction

823145
value: -1000.0
type: LocalParameter

854826
product: 854886
reactant: 854850
fast: false
reversible: false
reactant: 854838
notes: GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Triglycerol Degradation
type: Reaction
product: 854862
kinetic law: 854898
product: 854874
name: triacylglycerol hydrolase, human myocyte

768981
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Pyruvate
type: Species

774063
stoichiometry: 1.0
species: 771936
type: SpeciesReference

784601
stoichiometry: 1.0
species: 768335
type: SpeciesReference

801951
stoichiometry: 1.0
species: 766748
type: SpeciesReference

782132
value: -1000.0
type: LocalParameter

780006
name: acetyl-CoA carboxylase
product: 780066
product: 780090
product: 780078
type: Reaction
product: 780054
reactant: 780042
notes: GENE_ASSOCIATION: (NM_198839.1 or NM_198836.1 or NM_198837.1 or NM_198838.1 or NM_001093.2 or NM_198834.1) GENE_LIST: NM_001093.2 NM_198834.1 NM_198836.1 NM_198837.1 NM_198838.1 NM_198839.1 SUBSYSTEM: Citrate Cycle (TCA)
reactant: 780030
reactant: 780018
reversible: false
kinetic law: 780102
fast: false

795267
stoichiometry: 1.0
species: 768569
type: SpeciesReference

797877
value: 1000.0
type: LocalParameter

780778
value: 500.0
type: LocalParameter

811382
value: 0.0
type: LocalParameter

822273
value: -1000.0
type: LocalParameter

831971
value: 1000.0
type: LocalParameter

793803
stoichiometry: 1.0
species: 766628
type: SpeciesReference

791357
value: 0.0
type: LocalParameter

802768
kinetic law: 802864
type: Reaction
product: 802852
reactant: 802816
reactant: 802804
product: 802828
notes: SUBSYSTEM: Fatty Acid Desaturation
reactant: 802780
fast: false
reactant: 802792
product: 802840
name: Palmitoyl-CoA desaturase (n-C16:0CoA -> C16:1CoA, n-9)
reversible: false

822914
value: 0.0
type: LocalParameter

851469
value: 1000.0
type: LocalParameter

778875
kinetic law: 778911
product: 778899
reactant: 778887
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

791117
value: 0.0
type: LocalParameter

766482
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: CDPdiacylglycerol, human adipocyte
type: Species

824625
stoichiometry: 1.0
species: 767585
type: SpeciesReference

844871
stoichiometry: 1.0
species: 769005
type: SpeciesReference

781856
stoichiometry: 1.0
species: 766228
type: SpeciesReference

803445
stoichiometry: 1.0
species: 769101
type: SpeciesReference

776567
stoichiometry: 1.0
species: 765539
type: SpeciesReference

800466
value: 0.0
type: LocalParameter

765720
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: (R)-Pantothenate
type: Species

788722
stoichiometry: 0.001
species: 770973
type: SpeciesReference

835169
stoichiometry: 1.0
species: 770538
type: SpeciesReference

777643
stoichiometry: 1.0
species: 772382
type: SpeciesReference

803759
stoichiometry: 1.0
species: 768520
type: SpeciesReference

815366
stoichiometry: 1.0
species: 770768
type: SpeciesReference

808477
value: -1000.0
type: LocalParameter

841005
stoichiometry: 1.0
species: 767779
type: SpeciesReference

819588
stoichiometry: 2.0
species: 768335
type: SpeciesReference

839071
stoichiometry: 1.0
species: 770647
type: SpeciesReference

798930
stoichiometry: 1.0
species: 771144
type: SpeciesReference

776677
stoichiometry: 1.0
species: 772262
type: SpeciesReference

831551
value: 500.0
type: LocalParameter

806107
stoichiometry: 1.0
species: 767052
type: SpeciesReference

767306
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatrienoyl-CoA (C20:3CoA, n-6)
type: Species

807839
stoichiometry: 1.0
species: 767827
type: SpeciesReference

847787
value: 0.0
type: LocalParameter

794320
stoichiometry: 1.0
species: 770405
type: SpeciesReference

826823
stoichiometry: 1.0
species: 768909
type: SpeciesReference

801418
stoichiometry: 0.001
species: 768690
type: SpeciesReference

802492
stoichiometry: 1.0
species: 768359
type: SpeciesReference

809344
value: -1000.0
type: LocalParameter

829233
stoichiometry: 1.0
species: 767791
type: SpeciesReference

820364
stoichiometry: 2.0
species: 768323
type: SpeciesReference

771840
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ala_L_b
type: Species

848299
product: 848361
reactant: 848311
product: 848373
type: Reaction
name: phosphoribosylglycinamide synthetase
reactant: 848323
reactant: 848336
product: 848349
reversible: false
kinetic law: 848397
notes: GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Nucleotide Metabolism
product: 848385
fast: false

816970
stoichiometry: 1.0
species: 769971
type: SpeciesReference

801141
stoichiometry: 0.001
species: 765864
type: SpeciesReference

850393
value: 0.0
type: LocalParameter

770586
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: (S)-Methylmalonate semialdehyde
type: Species

807972
stoichiometry: 1.0
species: 766616
type: SpeciesReference

816681
stoichiometry: 10.0
species: 770333
type: SpeciesReference

794971
value: 0.0
type: LocalParameter

853082
reversible: true
reactant: 853107
type: Reaction
reactant: 853094
product: 853132
name: succinate dehydrogenase
notes: GENE_ASSOCIATION: ((NM_003000.1 and NM_003001.3 and NM_003002.1 and NM_004168.1) or (NM_001035513.1 and NM_003000.1 and NM_003002.1 and NM_004168.1) or (NM_001035512.1 and NM_003000.1 and NM_003002.1 and NM_004168.1) or (NM_001035511.1 and NM_003000.1 and NM_003002.1 and NM_004168.1)) GENE_LIST: NM_001035511.1 NM_001035512.1 NM_001035513.1 NM_003000.1 NM_003001.3 NM_003002.1 NM_004168.1 SUBSYSTEM: Citrate Cycle (TCA)
product: 853120
fast: false
kinetic law: 853145

792092
type: Reaction
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 792116
name: carnitine eicosenoyltransferase (C20:1Crn, n11), mitochondrial
fast: false
product: 792140
reactant: 792104
product: 792128
reversible: true
kinetic law: 792153

816319
stoichiometry: 9.0
species: 770333
type: SpeciesReference

814544
value: 1000.0
type: LocalParameter

848604
kinetic law: 848702
reactant: 848629
product: 848678
reversible: true
type: Reaction
product: 848653
product: 848665
reactant: 848641
notes: GENE_ASSOCIATION: (NM_006452.3 or NM_001079525.1 or NM_001079524.1) GENE_LIST: NM_001079524.1 NM_001079525.1 NM_006452.3 SUBSYSTEM: Nucleotide Metabolism
fast: false
product: 848690
reactant: 848616
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase

834146
value: 0.0
type: LocalParameter

844005
value: 0.0
type: LocalParameter

782290
product: 782362
reactant: 782326
reversible: false
product: 782374
name: adenylosuccinate synthetase
kinetic law: 782386
notes: GENE_ASSOCIATION: (NM_152328.3 or NM_199165.1 or NM_001126.2) GENE_LIST: NM_001126.2 NM_152328.3 NM_199165.1 SUBSYSTEM: Nucleotide Metabolism
type: Reaction
reactant: 782314
fast: false
reactant: 782302
product: 782338
product: 782350

852633
value: 0.0
type: LocalParameter

842418
value: -1000.0
type: LocalParameter

827949
value: 1000.0
type: LocalParameter

806327
stoichiometry: 1.0
species: 770345
type: SpeciesReference

805950
stoichiometry: 1.0
species: 771624
type: SpeciesReference

820011
stoichiometry: 2.0
species: 768323
type: SpeciesReference

831251
value: 0.0
type: LocalParameter

799607
reactant: 799631
product: 799655
reactant: 799643
name: citrate synthase
notes: GENE_ASSOCIATION: (NM_198324.1 or NM_004077.2) GENE_LIST: NM_004077.2 NM_198324.1 SUBSYSTEM: Citrate Cycle (TCA)
product: 799680
kinetic law: 799692
fast: false
reactant: 799619
type: Reaction
product: 799667
reversible: false

827610
kinetic law: 827671
product: 827659
type: Reaction
fast: false
product: 827646
notes: GENE_ASSOCIATION: ((NM_004130.2 and NM_002103.3) or (NM_004130.2 and NM_021957.2) or (NM_001079855.1 and NM_002103.3) or (NM_003918.1 and NM_002103.3) or (NM_001079855.1 and NM_021957.2) or (NM_003918.1 and NM_021957.2)) GENE_LIST: NM_001079855.1 NM_002103.3 NM_003918.1 NM_004130.2 NM_021957.2 SUBSYSTEM: Glycogen Metabolism
name: glycogen synthase (UDPGlc)
product: 827634
reversible: false
reactant: 827622

851746
product: 851794
reactant: 851770
kinetic law: 851806
type: Reaction
name: superoxide dismutase
product: 851782
reactant: 851758
reversible: false
fast: false
notes: GENE_ASSOCIATION: NM_000454.4 GENE_LIST: NM_000454.4 SUBSYSTEM: Other

849670
fast: false
reactant: 849695
product: 849719
name: Phosphatidylserine synthase 1, human adipocyte
kinetic law: 849732
type: Reaction
reactant: 849683
product: 849707
notes: GENE_ASSOCIATION: NM_014754.1 GENE_LIST: NM_014754.1 SUBSYSTEM: Phospholipid Metabolism
reversible: true

785539
stoichiometry: 1.0
species: 768800
type: SpeciesReference

819046
stoichiometry: 1.0
species: 768873
type: SpeciesReference

840390
value: 1000.0
type: LocalParameter

783864
stoichiometry: 1.0
species: 768298
type: SpeciesReference

810742
stoichiometry: 1.0
species: 766338
type: SpeciesReference

850176
stoichiometry: 1.0
species: 767767
type: SpeciesReference

795921
value: -1000.0
type: LocalParameter

849527
value: 1000.0
type: LocalParameter

786061
value: 1000.0
type: LocalParameter

766616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Coenzyme A
type: Species

832418
value: 1000.0
type: LocalParameter

779340
stoichiometry: 1.0
species: 768359
type: SpeciesReference

813417
value: 0.0
type: LocalParameter

766821
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dCTP
type: Species

830889
stoichiometry: 1.0
species: 770345
type: SpeciesReference

768262
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: (S)-Methylmalonate semialdehyde
type: Species

825438
value: -1000.0
type: LocalParameter

834434
stoichiometry: 1.0
species: 771396
type: SpeciesReference

810959
value: 0.0
type: LocalParameter

797562
stoichiometry: 1.0
species: 769851
type: SpeciesReference

843385
stoichiometry: 2.0
species: 767767
type: SpeciesReference

846855
stoichiometry: 1.0
species: 765720
type: SpeciesReference

854292
value: -1000.0
type: LocalParameter

791573
value: 1000.0
type: LocalParameter

821960
value: 0.0
type: LocalParameter

795535
stoichiometry: 1.0
species: 770841
type: SpeciesReference

776943
kinetic law: 776979
product: 776967
reactant: 776955
fast: false
reversible: true
name: Ammonium exchange
type: Reaction

817669
value: 500.0
type: LocalParameter

789975
value: 1000.0
type: LocalParameter

774802
value: 500.0
type: LocalParameter

779581
stoichiometry: 1.0
species: 769657
type: SpeciesReference

836073
stoichiometry: 1.0
species: 768142
type: SpeciesReference

840195
stoichiometry: 1.0
species: 769730
type: SpeciesReference

810152
stoichiometry: 1.0
species: 767202
type: SpeciesReference

855517
value: 500.0
type: LocalParameter

855395
stoichiometry: 1.0
species: 768359
type: SpeciesReference

775019
stoichiometry: 1.0
species: 765345
type: SpeciesReference

790072
stoichiometry: 1.0
species: 770333
type: SpeciesReference

838843
stoichiometry: 1.0
species: 768190
type: SpeciesReference

811672
stoichiometry: 1.0
species: 766604
type: SpeciesReference

796057
value: 1000.0
type: LocalParameter

792410
value: -1000.0
type: LocalParameter

853783
stoichiometry: 1.0
species: 770333
type: SpeciesReference

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stoichiometry: 1.0
species: 770333
type: SpeciesReference

850937
stoichiometry: 1.0
species: 769005
type: SpeciesReference

776254
value: 500.0
type: LocalParameter

786133
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species: 766386
type: SpeciesReference

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species: 767767
type: SpeciesReference

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species: 770153
type: SpeciesReference

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species: 768286
type: SpeciesReference

778729
value: 0.0
type: LocalParameter

852210
value: 1000.0
type: LocalParameter

819155
value: 0.0
type: LocalParameter

805344
stoichiometry: 1.0
species: 766932
type: SpeciesReference

838276
fast: false
name: 3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
product: 838349
kinetic law: 838361
type: Reaction
notes: GENE_ASSOCIATION: (((NM_000709.2 and NM_183050.1) and NM_001918.1 and NM_000108.3) or ((NM_000056.2 and NM_000709.2) and NM_001918.1 and NM_000108.3)) GENE_LIST: NM_000056.2 NM_000108.3 NM_000709.2 NM_001918.1 NM_183050.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 838288
reactant: 838300
reactant: 838312
reversible: false
product: 838337
product: 838324

845319
stoichiometry: 1.0
species: 771288
type: SpeciesReference

836111
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species: 768335
type: SpeciesReference

783974
reactant: 783986
kinetic law: 784047
product: 784035
reactant: 783998
reversible: false
product: 784023
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
fast: false
notes: GENE_ASSOCIATION: (NM_153326.1 or NM_006066.2) GENE_LIST: NM_006066.2 NM_153326.1 SUBSYSTEM: Cholesterol Metabolism
product: 784011
type: Reaction

808020
stoichiometry: 1.0
species: 768885
type: SpeciesReference

840740
value: -1000.0
type: LocalParameter

835808
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species: 770538
type: SpeciesReference

826079
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species: 767621
type: SpeciesReference

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species: 770345
type: SpeciesReference

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type: LocalParameter

817211
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species: 770165
type: SpeciesReference

779692
stoichiometry: 1.0
species: 766144
type: SpeciesReference

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stoichiometry: 0.002
species: 767112
type: SpeciesReference

767416
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: average fatty-acyl CoA, human adipocyte
type: Species

772286
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: na1_b
type: Species

766506
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3',5'-Cyclic GMP
type: Species

796786
value: 1000.0
type: LocalParameter

787018
stoichiometry: 1.0
species: 771264
type: SpeciesReference

829560
value: -1000.0
type: LocalParameter

819264
stoichiometry: 1.0
species: 767779
type: SpeciesReference

828070
value: 0.0
type: LocalParameter

813162
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species: 770333
type: SpeciesReference

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species: 768739
type: SpeciesReference

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stoichiometry: 1.0
species: 768800
type: SpeciesReference

774959
value: -1000.0
type: LocalParameter

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species: 770333
type: SpeciesReference

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species: 772141
type: SpeciesReference

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species: 770165
type: SpeciesReference

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species: 767779
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: octadecatrienoate (C18:3, n-3)
type: Species

772907
stoichiometry: 0.009515
species: 768788
type: SpeciesReference

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value: -1000.0
type: LocalParameter

853194
value: 0.0
type: LocalParameter

776833
value: -5.16871499999995E-5
type: LocalParameter

765515
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Isoleucine
type: Species

837780
value: 0.0
type: LocalParameter

791948
value: 0.0
type: LocalParameter

817513
stoichiometry: 1.0
species: 770153
type: SpeciesReference

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stoichiometry: 1.0
species: 771276
type: SpeciesReference

813308
stoichiometry: 1.0
species: 771144
type: SpeciesReference

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stoichiometry: 1.0
species: 769198
type: SpeciesReference

817235
stoichiometry: 10.0
species: 770634
type: SpeciesReference

852900
value: 0.0
type: LocalParameter

827500
value: 500.0
type: LocalParameter

820169
stoichiometry: 2.0
species: 766616
type: SpeciesReference

815089
value: 1000.0
type: LocalParameter

843277
stoichiometry: 1.0
species: 770333
type: SpeciesReference

808237
name: fatty-acid--CoA ligase (heptadecanoate, C17:0)
product: 808297
notes: GENE_ASSOCIATION: (NM_203379.1 or NM_001009185.1 or NM_203380.1 or NM_016234.3 or NM_015256.2 or NM_001995.2 or NM_004458.1 or NM_022977.1 or NM_004457.3 or NM_203372.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reversible: true
reactant: 808249
product: 808285
reactant: 808261
fast: false
product: 808309
reactant: 808273
kinetic law: 808321
type: Reaction

828835
value: -1000.0
type: LocalParameter

779232
stoichiometry: 1.0
species: 771288
type: SpeciesReference

821851
value: 500.0
type: LocalParameter

798686
stoichiometry: 1.0
species: 771180
type: SpeciesReference

849464
stoichiometry: 1.0
species: 768957
type: SpeciesReference

811902
stoichiometry: 3.0
species: 767779
type: SpeciesReference

818493
stoichiometry: 2.0
species: 768335
type: SpeciesReference

808585
stoichiometry: 1.0
species: 768885
type: SpeciesReference

792957
stoichiometry: 1.0
species: 767228
type: SpeciesReference

855663
stoichiometry: 1.0
species: 765828
type: SpeciesReference

791009
kinetic law: 791069
type: Reaction
reversible: true
reactant: 791033
reactant: 791021
fast: false
product: 791057
product: 791045
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
name: docosenoyl carnitine transport (C22:1Crn, n9)

849319
reactant: 849343
reversible: true
type: Reaction
kinetic law: 849379
reactant: 849331
notes: GENE_ASSOCIATION: (NM_058179.2 or NM_021154.3) GENE_LIST: NM_021154.3 NM_058179.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 849355
fast: false
name: 3-phosphoserine aminotransferase
product: 849367

765876
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-Phospho-D-glyceroyl phosphate
type: Species

839978
stoichiometry: 1.0
species: 766240
type: SpeciesReference

833276
value: 500.0
type: LocalParameter

796919
value: 0.0
type: LocalParameter

835278
stoichiometry: 1.0
species: 768142
type: SpeciesReference

805090
stoichiometry: 1.0
species: 766920
type: SpeciesReference

809850
stoichiometry: 1.0
species: 766616
type: SpeciesReference

803868
reactant: 803880
kinetic law: 803966
type: Reaction
fast: false
product: 803941
product: 803953
name: stearoyl-CoA desaturase (n-C20:0CoA -> C20:1CoA, n-11)
reactant: 803893
notes: GENE_ASSOCIATION: (NM_005063.4 or NM_024906.1 or NM_001037582.1) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Desaturation
reactant: 803917
reactant: 803905
reversible: false
product: 803929

791465
value: 0.0
type: LocalParameter

827234
type: Reaction
kinetic law: 827294
name: glycine C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: NM_014291.2 GENE_LIST: NM_014291.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
reversible: true
product: 827270
product: 827282
reactant: 827246
reactant: 827258
fast: false

841114
stoichiometry: 1.0
species: 766338
type: SpeciesReference

830731
value: 500.0
type: LocalParameter

777932
stoichiometry: 1.0
species: 772418
type: SpeciesReference

769343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: UDPglucose
type: Species

795813
value: 1000.0
type: LocalParameter

809561
stoichiometry: 1.0
species: 766616
type: SpeciesReference

786350
stoichiometry: 1.0
species: 766240
type: SpeciesReference

788831
stoichiometry: 1.0
species: 766592
type: SpeciesReference

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stoichiometry: 1.0
species: 766398
type: SpeciesReference

766374
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Asparagine
type: Species

765938
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Glycerate 2-phosphate
type: Species

818334
stoichiometry: 1.0
species: 769657
type: SpeciesReference

770477
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Isobutyryl-CoA
type: Species

821533
value: 1000.0
type: LocalParameter

788286
stoichiometry: 1.0
species: 767633
type: SpeciesReference

827306
value: -1000.0
type: LocalParameter

848714
value: -1000.0
type: LocalParameter

829342
stoichiometry: 1.0
species: 767779
type: SpeciesReference

832914
value: 0.0
type: LocalParameter

820255
reactant: 820279
product: 820327
reactant: 820267
name: fatty acid synthase (n-C6:0)
product: 820339
reactant: 820303
reversible: false
product: 820364
reactant: 820291
product: 820315
type: Reaction
product: 820351
kinetic law: 820376
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
fast: false

814654
stoichiometry: 9.0
species: 769657
type: SpeciesReference

838567
kinetic law: 838627
notes: SUBSYSTEM: Folate Metabolism
reactant: 838579
name: methenyltetrahydrofolate cyclohydrolase
product: 838615
reactant: 838591
reversible: true
type: Reaction
fast: false
product: 838603

809778
value: -1000.0
type: LocalParameter

801527
stoichiometry: 1.0
species: 766640
type: SpeciesReference

826578
value: -1000.0
type: LocalParameter

778597
stoichiometry: 1.0
species: 765792
type: SpeciesReference

768532
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecatrienoyl-CoA (C18:3CoA, n-6)
type: Species

784904
value: 0.0
type: LocalParameter

799389
stoichiometry: 1.0
species: 766628
type: SpeciesReference

851311
value: 0.0
type: LocalParameter

802384
stoichiometry: 1.0
species: 765249
type: SpeciesReference

854134
stoichiometry: 1.0
species: 767561
type: SpeciesReference

838409
value: 500.0
type: LocalParameter

847679
value: 0.0
type: LocalParameter

794862
value: 0.0
type: LocalParameter

790877
value: 0.0
type: LocalParameter

844174
stoichiometry: 1.0
species: 767779
type: SpeciesReference

824373
stoichiometry: 1.0
species: 768885
type: SpeciesReference

831815
stoichiometry: 1.0
species: 769645
type: SpeciesReference

843483
value: 500.0
type: LocalParameter

832732
stoichiometry: 1.0
species: 769693
type: SpeciesReference

780126
value: 1000.0
type: LocalParameter

812047
stoichiometry: 1.0
species: 768359
type: SpeciesReference

834796
stoichiometry: 1.0
species: 765551
type: SpeciesReference

810297
stoichiometry: 1.0
species: 766760
type: SpeciesReference

810405
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product: 810478
type: Reaction
reactant: 810429
name: fatty-acid--CoA ligase (docosenoate, C22:1 n-9)
product: 810454
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_001995.2 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_203372.1 or NM_203379.1) GENE_LIST: NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
kinetic law: 810490
product: 810466
reactant: 810417
reactant: 810441
fast: false

824216
stoichiometry: 1.0
species: 769718
type: SpeciesReference

766809
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosapentaenoate (C22:5, n-3)
type: Species

854728
stoichiometry: 1.0
species: 769234
type: SpeciesReference

821620
stoichiometry: 1.0
species: 767743
type: SpeciesReference

765430
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Bicarbonate
type: Species

775321
stoichiometry: 1.0
species: 772092
type: SpeciesReference

792628
stoichiometry: 1.0
species: 770093
type: SpeciesReference

844450
stoichiometry: 1.0
species: 766240
type: SpeciesReference

793066
reactant: 793078
type: Reaction
product: 793114
fast: false
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_152247.1 or NM_152245.1 or NM_001876.2 or NM_001031847.1 or NM_004377.2 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
product: 793102
kinetic law: 793126
reactant: 793090
name: carnitine eicosatetraenoyltransferase (C20:4Crn, n6)

770634
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Nicotinamide adenine dinucleotide - reduced
type: Species

845052
stoichiometry: 1.0
species: 765876
type: SpeciesReference

806872
value: 1000.0
type: LocalParameter

777498
value: 0.0
type: LocalParameter

829790
value: -1000.0
type: LocalParameter

823266
value: 0.0
type: LocalParameter

839532
value: 1000.0
type: LocalParameter

812337
value: 1000.0
type: LocalParameter

803880
stoichiometry: 1.0
species: 767125
type: SpeciesReference

783512
stoichiometry: 1.0
species: 770634
type: SpeciesReference

841776
stoichiometry: 1.0
species: 770865
type: SpeciesReference

801853
stoichiometry: 2.0
species: 767779
type: SpeciesReference

787359
value: 0.0
type: LocalParameter

823663
value: 1000.0
type: LocalParameter

776119
value: -6.51493E-5
type: LocalParameter

837612
kinetic law: 837648
product: 837636
reactant: 837624
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: (S)-Methylmalonate semialdehyde transport, mitochondrial
type: Reaction

767028
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosapentaenoyl carnitine (C22:5Crn, n-3)
type: Species

836207
stoichiometry: 1.0
species: 770538
type: SpeciesReference

821102
fast: false
reactant: 821128
kinetic law: 821167
reactant: 821115
product: 821154
reversible: false
notes: GENE_ASSOCIATION: (NM_000507.2 or NM_003837.2) GENE_LIST: NM_000507.2 NM_003837.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 821141
type: Reaction
name: fructose-bisphosphatase

833928
stoichiometry: 1.0
species: 768106
type: SpeciesReference

773373
stoichiometry: 1.0
species: 765141
type: SpeciesReference

794536
stoichiometry: 1.0
species: 767876
type: SpeciesReference

840837
value: -1000.0
type: LocalParameter

819999
stoichiometry: 1.0
species: 767779
type: SpeciesReference

772491
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: thr_L_b
type: Species

783379
stoichiometry: 1.0
species: 765925
type: SpeciesReference

773434
value: 0.0
type: LocalParameter

831130
kinetic law: 831214
product: 831178
product: 831202
notes: GENE_ASSOCIATION: NM_000859.1 GENE_LIST: NM_000859.1 SUBSYSTEM: Cholesterol Biosynthesis
name: Hydroxymethylglutaryl CoA reductase
reactant: 831166
fast: false
reactant: 831142
reversible: true
product: 831190
reactant: 831154
type: Reaction

835748
value: -1000.0
type: LocalParameter

770249
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Glutamine
type: Species

807623
value: 1000.0
type: LocalParameter

790853
value: 1000.0
type: LocalParameter

815294
value: 500.0
type: LocalParameter

785286
stoichiometry: 1.0
species: 768885
type: SpeciesReference

834880
product: 834917
product: 834943
product: 834930
fast: false
notes: GENE_ASSOCIATION: (NM_001003794.1 or NM_007283.5) GENE_LIST: NM_001003794.1 NM_007283.5 SUBSYSTEM: Triglycerol Degradation
name: monoacylglycerol hydrolase, human adipocyte
reversible: false
reactant: 834892
type: Reaction
kinetic law: 834956
reactant: 834904

819492
value: 0.0
type: LocalParameter

845476
value: 0.0
type: LocalParameter

789364
value: -1000.0
type: LocalParameter

811237
stoichiometry: 0.005
species: 768446
type: SpeciesReference

841342
value: 500.0
type: LocalParameter

771408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Farnesyl diphosphate
type: Species

806229
stoichiometry: 1.0
species: 771480
type: SpeciesReference

794656
stoichiometry: 1.0
species: 770393
type: SpeciesReference

847920
stoichiometry: 1.0
species: 770985
type: SpeciesReference

816898
value: 0.0
type: LocalParameter

804255
stoichiometry: 2.0
species: 767779
type: SpeciesReference

820460
stoichiometry: 1.0
species: 768009
type: SpeciesReference

768106
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Lactate
type: Species

813999
value: 0.0
type: LocalParameter

842515
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species: 771119
type: SpeciesReference

818890
stoichiometry: 1.0
species: 766616
type: SpeciesReference

809548
stoichiometry: 1.0
species: 766398
type: SpeciesReference

765237
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: docosapentaenoate (C22:5, n-3)
type: Species

781623
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product: 781659
reactant: 781647
reactant: 781635
notes: GENE_ASSOCIATION: (NM_013410.2 or NM_001005353.1 or NM_203464.1 or NM_013411.3 or NM_001625.2) GENE_LIST: NM_001005353.1 NM_001625.2 NM_013410.2 NM_013411.3 NM_203464.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: true
name: adenylate kinase, mitochondrial
type: Reaction

834995
value: 0.0
type: LocalParameter

793391
value: 1000.0
type: LocalParameter

816958
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species: 769851
type: SpeciesReference

816223
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product: 816331
product: 816307
reversible: false
reactant: 816247
reactant: 816271
kinetic law: 816343
reactant: 816259
reactant: 816283
fast: false
type: Reaction
product: 816319
name: Beta oxidation of fatty acid
product: 816295
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 or... SUBSYSTEM: Fatty acid oxidation

826237
stoichiometry: 1.0
species: 770273
type: SpeciesReference

789667
stoichiometry: 1.0
species: 766240
type: SpeciesReference

777787
value: 0.0
type: LocalParameter

850296
stoichiometry: 1.0
species: 766240
type: SpeciesReference

821327
value: 0.0
type: LocalParameter

788129
stoichiometry: 1.0
species: 771780
type: SpeciesReference

804800
value: 500.0
type: LocalParameter

828058
value: 0.0
type: LocalParameter

846179
value: 1000.0
type: LocalParameter

767743
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Reduced glutathione
type: Species

814920
value: 0.0
type: LocalParameter

826993
kinetic law: 827054
name: L-glutamate reversible transport via proton symport, mitochondrial
reactant: 827005
product: 827030
type: Reaction
notes: GENE_ASSOCIATION: (NM_031481.1 or NM_024698.4) GENE_LIST: NM_024698.4 NM_031481.1 SUBSYSTEM: Transport, Mitochondrial
product: 827042
reversible: true
fast: false
reactant: 827017

773796
value: -1000.0
type: LocalParameter

829137
stoichiometry: 1.0
species: 767791
type: SpeciesReference

771744
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Hydrogen peroxide
type: Species

791960
value: 0.0
type: LocalParameter

786909
stoichiometry: 1.0
species: 771528
type: SpeciesReference

839496
stoichiometry: 1.0
species: 768800
type: SpeciesReference

848373
stoichiometry: 1.0
species: 767767
type: SpeciesReference

791695
value: 1000.0
type: LocalParameter

827464
value: 0.0
type: LocalParameter

851107
value: 0.0
type: LocalParameter

767177
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosenoate (C20:1, n-9)
type: Species

843073
value: 0.0
type: LocalParameter

801696
stoichiometry: 0.001
species: 769778
type: SpeciesReference

806725
stoichiometry: 1.0
species: 765261
type: SpeciesReference

822140
value: 1000.0
type: LocalParameter

782498
stoichiometry: 0.002
species: 766992
type: SpeciesReference

816742
value: 0.0
type: LocalParameter

799510
stoichiometry: 1.0
species: 766628
type: SpeciesReference

812905
stoichiometry: 1.0
species: 770345
type: SpeciesReference

779027
value: -2.07387999999999E-4
type: LocalParameter

849234
stoichiometry: 1.0
species: 766604
type: SpeciesReference

842624
stoichiometry: 1.0
species: 766604
type: SpeciesReference

770357
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Hydrogen peroxide
type: Species

816452
stoichiometry: 9.0
species: 770345
type: SpeciesReference

838421
fast: false
reversible: false
product: 838470
product: 838482
reactant: 838433
reactant: 838458
name: 3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
kinetic law: 838506
product: 838494
reactant: 838446
notes: GENE_ASSOCIATION: (((NM_000056.2 and NM_000709.2) and NM_001918.1 and NM_000108.3) or ((NM_000709.2 and NM_183050.1) and NM_001918.1 and NM_000108.3)) GENE_LIST: NM_000056.2 NM_000108.3 NM_000709.2 NM_001918.1 NM_183050.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
type: Reaction

813842
stoichiometry: 1.0
species: 769851
type: SpeciesReference

822032
value: -1000.0
type: LocalParameter

799171
stoichiometry: 1.0
species: 771034
type: SpeciesReference

805636
stoichiometry: 1.0
species: 768885
type: SpeciesReference

809113
stoichiometry: 1.0
species: 766398
type: SpeciesReference

828409
stoichiometry: 1.0
species: 766252
type: SpeciesReference

847811
value: 0.0
type: LocalParameter

841499
value: -1000.0
type: LocalParameter

796348
stoichiometry: 1.0
species: 766628
type: SpeciesReference

789220
stoichiometry: 1.0
species: 766240
type: SpeciesReference

855964
value: 0.0
type: LocalParameter

824796
stoichiometry: 0.002
species: 767125
type: SpeciesReference

769633
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Acetate
type: Species

789510
kinetic law: 789546
product: 789534
reactant: 789522
notes: GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: cholestenol delta-isomerase
type: Reaction

852840
stoichiometry: 1.0
species: 771444
type: SpeciesReference

800019
stoichiometry: 1.0
species: 768800
type: SpeciesReference

830467
value: 0.0
type: LocalParameter

781514
kinetic law: 781563
product: 781551
reactant: 781539
reactant: 781526
notes: GENE_ASSOCIATION: (NM_012093.2 or NM_000476.1 or NM_152327.1 or NM_174858.1) GENE_LIST: NM_000476.1 NM_012093.2 NM_152327.1 NM_174858.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: true
name: adenylate kinase
type: Reaction

774050
stoichiometry: 1.0
species: 765225
type: SpeciesReference

777342
stoichiometry: 1.0
species: 765635
type: SpeciesReference

846288
value: -1000.0
type: LocalParameter

805078
type: Reaction
reactant: 805090
product: 805126
fast: false
kinetic law: 805150
notes: GENE_ASSOCIATION: NM_000791.3 GENE_LIST: NM_000791.3 SUBSYSTEM: Folate Metabolism
reversible: true
reactant: 805114
name: dihydrofolate reductase
product: 805138
reactant: 805102

835965
stoichiometry: 1.0
species: 769839
type: SpeciesReference

769911
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: dodecanoylcarnitine (C12:0Crn)
type: Species

800888
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: NM_207315.1 GENE_LIST: NM_207315.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reactant: 800912
reactant: 800900
name: cytidylate kinase (CMP), mitochondrial
kinetic law: 800948
product: 800924
product: 800936

765950
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-(4-Hydroxyphenyl)pyruvate
type: Species

829028
stoichiometry: 1.0
species: 767755
type: SpeciesReference

831419
type: Reaction
product: 831479
reversible: false
reactant: 831431
reactant: 831443
kinetic law: 831503
product: 831467
notes: GENE_ASSOCIATION: NM_005518.2 GENE_LIST: NM_005518.2 SUBSYSTEM: Cholesterol Metabolism
product: 831491
reactant: 831455
name: Hydroxymethylglutaryl CoA synthase (ir)
fast: false

787600
stoichiometry: 1.0
species: 771540
type: SpeciesReference

814811
stoichiometry: 8.0
species: 770622
type: SpeciesReference

795103
value: 0.0
type: LocalParameter

794164
stoichiometry: 1.0
species: 766628
type: SpeciesReference

837346
stoichiometry: 1.0
species: 768226
type: SpeciesReference

839386
value: -1000.0
type: LocalParameter

771636
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: (R)-5-Phosphomevalonate
type: Species

805780
value: 0.0
type: LocalParameter

822708
kinetic law: 822756
product: 822744
reactant: 822732
reactant: 822720
notes: GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Citrate Cycle (TCA)
fast: false
reversible: true
name: fumarase, mitochondrial
type: Reaction

805938
product: 805974
type: Reaction
reactant: 805950
name: diphosphomevalonate decarboxylase
kinetic law: 806022
fast: false
reactant: 805962
reversible: false
notes: SUBSYSTEM: Cholesterol Metabolism
product: 805986
product: 805998
product: 806010

816112
stoichiometry: 10.0
species: 769657
type: SpeciesReference

842722
stoichiometry: 1.0
species: 768630
type: SpeciesReference

794766
stoichiometry: 1.0
species: 767900
type: SpeciesReference

774742
stoichiometry: 1.0
species: 772020
type: SpeciesReference

830443
value: -1000.0
type: LocalParameter

843593
value: 1000.0
type: LocalParameter

786567
value: 0.0
type: LocalParameter

779135
stoichiometry: 1.0
species: 769077
type: SpeciesReference

810514
value: 1000.0
type: LocalParameter

793683
stoichiometry: 1.0
species: 767319
type: SpeciesReference

807515
fast: false
reactant: 807539
kinetic law: 807599
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_001995.2 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_203372.1 or NM_203379.1) GENE_LIST: NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reactant: 807527
product: 807575
reversible: true
reactant: 807551
name: fatty-acid--CoA ligase (tetradecenoate, C14:1 n-5)
type: Reaction
product: 807587
product: 807563

832623
stoichiometry: 1.0
species: 769693
type: SpeciesReference

830032
value: -1000.0
type: LocalParameter

793174
value: 0.0
type: LocalParameter

787864
value: 500.0
type: LocalParameter

821730
stoichiometry: 1.0
species: 767779
type: SpeciesReference

853459
value: 0.0
type: LocalParameter

850708
stoichiometry: 1.0
species: 769330
type: SpeciesReference

790421
value: 0.0
type: LocalParameter

854838
stoichiometry: 1.0
species: 767779
type: SpeciesReference

823157
value: 1000.0
type: LocalParameter

810850
stoichiometry: 1.0
species: 766398
type: SpeciesReference

811514
stoichiometry: 3.0
species: 767779
type: SpeciesReference

797719
stoichiometry: 1.0
species: 770937
type: SpeciesReference

845767
stoichiometry: 1.0
species: 766908
type: SpeciesReference

844643
value: 1000.0
type: LocalParameter

845161
reactant: 845173
reactant: 845185
fast: false
notes: GENE_ASSOCIATION: NM_012088.2 GENE_LIST: NM_012088.2 SUBSYSTEM: Pentose Phosphate Pathway
name: 6-phosphogluconolactonase
kinetic law: 845222
product: 845209
reversible: false
product: 845197
type: Reaction

785842
value: 0.0
type: LocalParameter

801963
stoichiometry: 1.0
species: 767767
type: SpeciesReference

784613
stoichiometry: 1.0
species: 768981
type: SpeciesReference

767851
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: hexadecenoate (C16:1, n-9)
type: Species

768993
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: alpha-D-Ribose 5-phosphate
type: Species

768800
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Phosphate
type: Species

785178
kinetic law: 785298
product: 785238
reactant: 785190
name: asparagine synthase (glutamine-hydrolysing)
reactant: 785202
reactant: 785214
notes: GENE_ASSOCIATION: (NM_001673.2 or NM_133436.1 or NM_183356.1) GENE_LIST: NM_001673.2 NM_133436.1 NM_183356.1 SUBSYSTEM: Alanine and Aspartate Metabolism
product: 785250
product: 785262
reversible: false
product: 785274
reactant: 785226
type: Reaction
product: 785286
fast: false

839059
stoichiometry: 1.0
species: 770562
type: SpeciesReference

826091
stoichiometry: 1.0
species: 767767
type: SpeciesReference

775998
stoichiometry: 1.0
species: 772177
type: SpeciesReference

831022
stoichiometry: 1.0
species: 765479
type: SpeciesReference

849756
value: 1000.0
type: LocalParameter

787468
stoichiometry: 1.0
species: 771264
type: SpeciesReference

791804
value: -1000.0
type: LocalParameter

794428
stoichiometry: 1.0
species: 766628
type: SpeciesReference

793283
value: 0.0
type: LocalParameter

765129
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Alanine
type: Species

804401
stoichiometry: 1.0
species: 767293
type: SpeciesReference

834374
stoichiometry: 2.0
species: 771444
type: SpeciesReference

837720
stoichiometry: 1.0
species: 770574
type: SpeciesReference

799099
value: 0.0
type: LocalParameter

825195
stoichiometry: 1.0
species: 768238
type: SpeciesReference

785442
value: 1000.0
type: LocalParameter

846421
value: 1000.0
type: LocalParameter

823771
value: 0.0
type: LocalParameter

771516
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Nicotinamide adenine dinucleotide phosphate
type: Species

803772
stoichiometry: 2.0
species: 767779
type: SpeciesReference

784760
value: 0.0
type: LocalParameter

783222
stoichiometry: 1.0
species: 769513
type: SpeciesReference

829245
stoichiometry: 1.0
species: 771744
type: SpeciesReference

831563
kinetic law: 831599
product: 831587
reactant: 831575
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
type: Reaction

806119
stoichiometry: 1.0
species: 766240
type: SpeciesReference

832309
value: 500.0
type: LocalParameter

777908
kinetic law: 777944
product: 777932
reactant: 777920
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

801406
stoichiometry: 1.0
species: 767779
type: SpeciesReference

769790
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Citrate
type: Species

770574
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Methylmalonate
type: Species

807960
stoichiometry: 1.0
species: 766398
type: SpeciesReference

825002
stoichiometry: 0.243
species: 768825
type: SpeciesReference

777630
stoichiometry: 1.0
species: 765672
type: SpeciesReference

854448
value: 0.0
type: LocalParameter

771852
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: arg_L_b
type: Species

809970
reactant: 809983
product: 810019
name: fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-6), hepatocyte
product: 810031
reversible: true
type: Reaction
kinetic law: 810055
reactant: 810007
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203372.1 or NM_203380.1 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_001009185.1 or NM_015256.2 or NM_016234.3) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
fast: false
reactant: 809995
product: 810043

801153
stoichiometry: 1.0
species: 766470
type: SpeciesReference

781940
value: 1000.0
type: LocalParameter

848616
stoichiometry: 1.0
species: 766058
type: SpeciesReference

814556
value: 0.0
type: LocalParameter

820351
stoichiometry: 1.0
species: 768009
type: SpeciesReference

794983
value: 0.0
type: LocalParameter

853070
value: 500.0
type: LocalParameter

816307
stoichiometry: 6.0
species: 770165
type: SpeciesReference

834158
value: 0.0
type: LocalParameter

844017
value: 500.0
type: LocalParameter

811394
value: 0.0
type: LocalParameter

831983
value: 0.0
type: LocalParameter

846106
stoichiometry: 1.0
species: 767767
type: SpeciesReference

793815
stoichiometry: 1.0
species: 767125
type: SpeciesReference

822285
value: 1000.0
type: LocalParameter

842940
value: 1000.0
type: LocalParameter

782144
value: 1000.0
type: LocalParameter

781843
type: Reaction
fast: false
reactant: 781868
product: 781880
reversible: false
kinetic law: 781916
reactant: 781856
notes: GENE_ASSOCIATION: (NM_006721.2 or NM_001123.2) GENE_LIST: NM_001123.2 NM_006721.2 SUBSYSTEM: Nucleotide Metabolism
product: 781904
product: 781892
name: adenosine kinase

780018
stoichiometry: 1.0
species: 766204
type: SpeciesReference

795255
stoichiometry: 1.0
species: 766628
type: SpeciesReference

766470
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: CDPcholine
type: Species

778887
stoichiometry: 1.0
species: 765828
type: SpeciesReference

850068
stoichiometry: 1.0
species: 768776
type: SpeciesReference

812616
value: 0.0
type: LocalParameter

824637
stoichiometry: 1.0
species: 767464
type: SpeciesReference

802756
value: 500.0
type: LocalParameter

791369
product: 791405
product: 791417
reactant: 791393
kinetic law: 791429
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
fast: false
reversible: true
reactant: 791381
type: Reaction
name: docosahexaenoyl carnitine transport (C22:6Crn, n3)

822926
value: 0.0
type: LocalParameter

812760
stoichiometry: 1.0
species: 770333
type: SpeciesReference

765732
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Proline
type: Species

776579
stoichiometry: 1.0
species: 772250
type: SpeciesReference

786495
stoichiometry: 1.0
species: 766240
type: SpeciesReference

800478
value: 1000.0
type: LocalParameter

803432
stoichiometry: 1.0
species: 768359
type: SpeciesReference

791129
reactant: 791153
product: 791165
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_001876.2 or NM_001031847.1 or NM_004377.2 or NM_152359.1 or NM_152247.1 or NM_152245.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reactant: 791141
kinetic law: 791189
product: 791177
name: carnitine docosahexaenoyltransferase (C22:6Crn, n3)
type: Reaction
reversible: true
fast: false

841017
stoichiometry: 1.0
species: 768800
type: SpeciesReference

851541
stoichiometry: 1.0
species: 768286
type: SpeciesReference

797187
product: 797224
fast: false
type: Reaction
reactant: 797200
reactant: 797212
name: carnitine octadecanoyltransferase (C18:0Crn), mitochondria
kinetic law: 797248
reversible: true
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 797236

808489
value: 1000.0
type: LocalParameter

770780
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecatrienoyl carnitine (C18:3Crn, n3)
type: Species

815378
stoichiometry: 9.0
species: 769657
type: SpeciesReference

813405
value: 1000.0
type: LocalParameter

788589
stoichiometry: 1.0
species: 765998
type: SpeciesReference

768274
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Methylglyoxal
type: Species

836086
stoichiometry: 1.0
species: 768323
type: SpeciesReference

849539
value: 0.0
type: LocalParameter

802540
stoichiometry: 1.0
species: 769161
type: SpeciesReference

766628
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Carnitine
type: Species

798240
value: 1000.0
type: LocalParameter

832406
value: 0.0
type: LocalParameter

854400
stoichiometry: 1.0
species: 767767
type: SpeciesReference

846843
stoichiometry: 1.0
species: 765575
type: SpeciesReference

791585
value: 0.0
type: LocalParameter

797574
stoichiometry: 1.0
species: 770937
type: SpeciesReference

834422
stoichiometry: 1.0
species: 771240
type: SpeciesReference

823519
value: 1000.0
type: LocalParameter

774814
kinetic law: 774850
product: 774838
reactant: 774826
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

811660
stoichiometry: 1.0
species: 768532
type: SpeciesReference

797864
value: -1000.0
type: LocalParameter

810140
stoichiometry: 1.0
species: 766616
type: SpeciesReference

779593
stoichiometry: 1.0
species: 771034
type: SpeciesReference

855529
reactant: 855541
product: 855566
type: Reaction
reversible: true
product: 855578
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Tyrosine metabolism
fast: false
reactant: 855553
kinetic law: 855590
name: tyrosine transaminase

780235
value: -1000.0
type: LocalParameter

776931
value: 0.0
type: LocalParameter

779353
stoichiometry: 1.0
species: 767791
type: SpeciesReference

817657
value: 0.0
type: LocalParameter

815594
stoichiometry: 1.0
species: 770634
type: SpeciesReference

853771
stoichiometry: 1.0
species: 770647
type: SpeciesReference

776266
kinetic law: 776302
product: 776290
reactant: 776278
fast: false
reversible: true
name: heptadecenoate (C17:1, n-8) exchange
type: Reaction

850925
stoichiometry: 1.0
species: 768993
type: SpeciesReference

813284
stoichiometry: 1.0
species: 770345
type: SpeciesReference

836776
stoichiometry: 1.0
species: 768178
type: SpeciesReference

786121
stoichiometry: 1.0
species: 765575
type: SpeciesReference

819384
stoichiometry: 1.0
species: 768154
type: SpeciesReference

855383
product: 855444
product: 855432
type: Reaction
fast: false
kinetic law: 855468
reactant: 855395
reactant: 855420
reactant: 855408
product: 855456
reversible: false
notes: GENE_ASSOCIATION: (NM_199292.2 or NM_199293.2 or NM_000360.3) GENE_LIST: NM_000360.3 NM_199292.2 NM_199293.2 SUBSYSTEM: Tyrosine metabolism
name: tyrosine 3-monooxygenase

796069
value: 0.0
type: LocalParameter

790060
stoichiometry: 1.0
species: 769827
type: SpeciesReference

838831
stoichiometry: 1.0
species: 768323
type: SpeciesReference

843374
stoichiometry: 1.0
species: 765901
type: SpeciesReference

827017
stoichiometry: 1.0
species: 767767
type: SpeciesReference

806339
stoichiometry: 1.0
species: 770429
type: SpeciesReference

827937
value: -1000.0
type: LocalParameter

775890
stoichiometry: 1.0
species: 765454
type: SpeciesReference

827622
stoichiometry: 1.0
species: 769343
type: SpeciesReference

812496
stoichiometry: 1.0
species: 769887
type: SpeciesReference

851758
stoichiometry: 2.0
species: 767767
type: SpeciesReference

779969
value: 1000.0
type: LocalParameter

825715
stoichiometry: 1.0
species: 771432
type: SpeciesReference

819058
stoichiometry: 6.0
species: 766604
type: SpeciesReference

799619
stoichiometry: 1.0
species: 769657
type: SpeciesReference

768678
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ocosatetraenoyl carnitine (C22:4Crn, n-6)
type: Species

767319
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatrienoyl carnitine (C20:3Crn, n-6)
type: Species

783876
stoichiometry: 1.0
species: 766192
type: SpeciesReference

783669
value: -1000.0
type: LocalParameter

849683
stoichiometry: 1.0
species: 766518
type: SpeciesReference

790577
stoichiometry: 1.0
species: 766858
type: SpeciesReference

825873
stoichiometry: 1.0
species: 768800
type: SpeciesReference

850188
stoichiometry: 1.0
species: 768981
type: SpeciesReference

810730
stoichiometry: 1.0
species: 766809
type: SpeciesReference

807731
stoichiometry: 1.0
species: 768885
type: SpeciesReference

778089
value: 500.0
type: LocalParameter

838130
product: 838203
kinetic law: 838215
notes: GENE_ASSOCIATION: (((NM_000709.2 and NM_183050.1) and NM_001918.1 and NM_000108.3) or ((NM_000056.2 and NM_000709.2) and NM_001918.1 and NM_000108.3)) GENE_LIST: NM_000056.2 NM_000108.3 NM_000709.2 NM_001918.1 NM_183050.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 838142
reactant: 838154
name: 3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
fast: false
product: 838179
reactant: 838167
product: 838191
reversible: false
type: Reaction

819276
stoichiometry: 1.0
species: 767827
type: SpeciesReference

829572
value: 1000.0
type: LocalParameter

838723
stoichiometry: 1.0
species: 769428
type: SpeciesReference

777088
value: -1000.0
type: LocalParameter

817501
stoichiometry: 1.0
species: 769851
type: SpeciesReference

798131
value: 0.0
type: LocalParameter

796629
stoichiometry: 1.0
species: 770780
type: SpeciesReference

776821
value: 0.0
type: LocalParameter

803190
value: 0.0
type: LocalParameter

837792
value: 0.0
type: LocalParameter

765503
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: heptadecenoate (C17:1, n-8)
type: Species

832515
stoichiometry: 1.0
species: 768335
type: SpeciesReference

787720
reactant: 787744
notes: GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Biosynthesis
reactant: 787732
product: 787768
type: Reaction
reversible: false
fast: false
kinetic law: 787816
product: 787780
reactant: 787756
name: C-4 methyl sterol oxidase NADPH
product: 787792
product: 787804

788698
stoichiometry: 1.0
species: 769827
type: SpeciesReference

853182
value: 0.0
type: LocalParameter

825317
stoichiometry: 1.0
species: 767597
type: SpeciesReference

798831
value: -1000.0
type: LocalParameter

797466
stoichiometry: 1.0
species: 766616
type: SpeciesReference

840050
value: 0.0
type: LocalParameter

815077
value: 0.0
type: LocalParameter

820157
stoichiometry: 1.0
species: 766604
type: SpeciesReference

843265
stoichiometry: 1.0
species: 770261
type: SpeciesReference

834578
value: 0.0
type: LocalParameter

844306
stoichiometry: 1.0
species: 771070
type: SpeciesReference

852912
value: 1000.0
type: LocalParameter

853880
kinetic law: 853916
product: 853904
reactant: 853892
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
type: Reaction

813175
stoichiometry: 1.0
species: 770634
type: SpeciesReference

802696
stoichiometry: 1.0
species: 768323
type: SpeciesReference

827512
kinetic law: 827549
product: 827537
reactant: 827524
notes: GENE_ASSOCIATION: (NM_004925.3 or NM_001170.1) GENE_LIST: NM_001170.1 NM_004925.3 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: glycerol transport in/out via diffusion reversible
type: Reaction

828847
value: 1000.0
type: LocalParameter

847217
stoichiometry: 1.0
species: 771456
type: SpeciesReference

808188
value: -1000.0
type: LocalParameter

808249
stoichiometry: 1.0
species: 766398
type: SpeciesReference

851989
reactant: 852013
type: Reaction
notes: SUBSYSTEM: ROS Detoxification
fast: false
product: 852026
kinetic law: 852050
reversible: false
product: 852038
reactant: 852001
name: superoxide dismutase, peroxisome

784035
stoichiometry: 1.0
species: 768335
type: SpeciesReference

838288
stoichiometry: 1.0
species: 769573
type: SpeciesReference

810622
stoichiometry: 1.0
species: 768885
type: SpeciesReference

805356
stoichiometry: 1.0
species: 767779
type: SpeciesReference

778199
kinetic law: 778235
product: 778223
reactant: 778211
fast: false
reversible: true
name: pentadecanoate (C15:0) exchange
type: Reaction

830190
value: 0.0
type: LocalParameter

819167
value: 500.0
type: LocalParameter

796202
value: 0.0
type: LocalParameter

852391
stoichiometry: 1.0
species: 771444
type: SpeciesReference

794008
value: 0.0
type: LocalParameter

783986
stoichiometry: 1.0
species: 767331
type: SpeciesReference

834000
value: -1000.0
type: LocalParameter

815149
stoichiometry: 6.0
species: 770153
type: SpeciesReference

789962
value: -1000.0
type: LocalParameter

817223
stoichiometry: 10.0
species: 770333
type: SpeciesReference

780996
stoichiometry: 1.0
species: 766168
type: SpeciesReference

848151
product: 848225
reactant: 848176
notes: GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Fatty acid activation
reactant: 848164
reactant: 848189
product: 848201
kinetic law: 848238
product: 848213
fast: false
type: Reaction
name: propionyl-CoA synthetase, mitochondrial
reversible: true

801261
product: 801309
fast: false
product: 801297
reactant: 801273
product: 801321
notes: GENE_ASSOCIATION: (NM_006133.1 or NM_139179.1) GENE_LIST: NM_006133.1 NM_139179.1 SUBSYSTEM: Triglycerol Degradation
type: Reaction
name: diacylglycerol hydrolase, human adipocyte
kinetic law: 801333
reversible: false
reactant: 801285

766518
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Choline
type: Species

841994
stoichiometry: 1.0
species: 768409
type: SpeciesReference

767428
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Formaldehyde
type: Species

796774
value: -1000.0
type: LocalParameter

772274
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: met_L_b
type: Species

780561
stoichiometry: 1.0
species: 766168
type: SpeciesReference

800734
value: 0.0
type: LocalParameter

821545
value: 0.0
type: LocalParameter

770465
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Hexanoyl-CoA (C6:0CoA)
type: Species

777003
value: 1000.0
type: LocalParameter

818322
stoichiometry: 1.0
species: 770683
type: SpeciesReference

804571
stoichiometry: 2.0
species: 767779
type: SpeciesReference

826944
value: -1000.0
type: LocalParameter

801515
reactant: 801527
type: Reaction
reactant: 801552
reversible: true
product: 801576
product: 801564
notes: GENE_ASSOCIATION: NM_001263.2 GENE_LIST: NM_001263.2 SUBSYSTEM: Phospholipid Metabolism
kinetic law: 801588
reactant: 801539
name: CDP-Diacylglycerol synthetase, human adipocyte
fast: false

832902
value: 1000.0
type: LocalParameter

827318
value: 1000.0
type: LocalParameter

814666
stoichiometry: 7.0
species: 770165
type: SpeciesReference

838579
stoichiometry: 1.0
species: 767779
type: SpeciesReference

788274
stoichiometry: 1.0
species: 766446
type: SpeciesReference

848726
value: 1000.0
type: LocalParameter

820243
value: 500.0
type: LocalParameter

771960
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ddca_b
type: Species

851323
value: 1000.0
type: LocalParameter

828277
stoichiometry: 2.0
species: 767767
type: SpeciesReference

798566
stoichiometry: 1.0
species: 771180
type: SpeciesReference

768520
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecatrienoyl-CoA (C18:3CoA, n-3)
type: Species

778585
kinetic law: 778621
product: 778609
reactant: 778597
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

794874
kinetic law: 794934
reactant: 794886
type: Reaction
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_152245.1 or NM_152246.1 or NM_001876.2 or NM_152359.1 or NM_004377.2 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
fast: false
reactant: 794898
reversible: true
product: 794910
product: 794922
name: carnitine octadecenoyltransferase (C18:1Crn, n5)

790865
value: 0.0
type: LocalParameter

841560
stoichiometry: 1.0
species: 768359
type: SpeciesReference

784468
stoichiometry: 1.0
species: 768250
type: SpeciesReference

794200
stoichiometry: 1.0
species: 767888
type: SpeciesReference

847667
value: 1000.0
type: LocalParameter

773217
value: 0.0
type: LocalParameter

818745
stoichiometry: 2.0
species: 768323
type: SpeciesReference

854146
stoichiometry: 1.0
species: 769017
type: SpeciesReference

824918
stoichiometry: 0.159
species: 768470
type: SpeciesReference

818481
stoichiometry: 1.0
species: 768154
type: SpeciesReference

834218
value: -1000.0
type: LocalParameter

808597
stoichiometry: 1.0
species: 769101
type: SpeciesReference

837188
value: 0.0
type: LocalParameter

851251
kinetic law: 851299
product: 851287
product: 851275
reactant: 851263
notes: GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
fast: false
reversible: false
name: L-serine deaminase
type: Reaction

849452
stoichiometry: 1.0
species: 767779
type: SpeciesReference

818601
value: 1000.0
type: LocalParameter

798674
stoichiometry: 1.0
species: 766628
type: SpeciesReference

784300
stoichiometry: 2.0
species: 770333
type: SpeciesReference

800588
value: 0.0
type: LocalParameter

849307
value: 500.0
type: LocalParameter

839966
stoichiometry: 1.0
species: 769330
type: SpeciesReference

765888
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 1-Acyl-sn-glycerol 3-phosphate, adipocyte
type: Species

792969
stoichiometry: 1.0
species: 769863
type: SpeciesReference

855675
stoichiometry: 1.0
species: 769318
type: SpeciesReference

851698
value: -1000.0
type: LocalParameter

791477
value: 0.0
type: LocalParameter

827246
stoichiometry: 1.0
species: 769657
type: SpeciesReference

769355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: UMP
type: Species

841126
stoichiometry: 1.0
species: 767779
type: SpeciesReference

854558
value: 1000.0
type: LocalParameter

809862
stoichiometry: 1.0
species: 767151
type: SpeciesReference

766362
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: N(omega)-(L-Arginino)succinate
type: Species

797296
value: 0.0
type: LocalParameter

833288
kinetic law: 833324
product: 833312
reactant: 833300
notes: GENE_ASSOCIATION: (NM_004508.2 or NM_033261.2) GENE_LIST: NM_004508.2 NM_033261.2 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: true
name: isopentenyl-diphosphate D-isomerase, peroxisomal
type: Reaction

803323
stoichiometry: 1.0
species: 768569
type: SpeciesReference

826676
stoichiometry: 1.0
species: 770671
type: SpeciesReference

781733
kinetic law: 781781
product: 781769
product: 781757
reactant: 781745
notes: GENE_ASSOCIATION: (NM_139247.2 or NM_183357.1 or NM_001115.1 or NM_018417.2 or NM_004036.2 or NM_020983.2 or NM_015270.2 or NM_001116.2 or NM_021116.1 or NM_020546.1 or NM_001114.2) GENE_LIST: NM_001114.2 NM_001115.1 NM_001116.2 NM_004036.2 NM_015270.2 NM_018417.2 NM_020546.1 NM_020983.2 NM_021116.1 NM_139247.2 NM_183357.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: false
name: adenylate cyclase
type: Reaction

830743
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
product: 830805
product: 830792
reactant: 830768
reversible: true
product: 830780
kinetic law: 830817
notes: GENE_ASSOCIATION: NM_152740.2 GENE_LIST: NM_152740.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 830756
type: Reaction
fast: false

773869
stoichiometry: 1.0
species: 771912
type: SpeciesReference

816004
value: 1000.0
type: LocalParameter

795801
value: -1000.0
type: LocalParameter

788843
stoichiometry: 0.001
species: 769065
type: SpeciesReference

834832
value: -1000.0
type: LocalParameter

852270
stoichiometry: 1.0
species: 769089
type: SpeciesReference

783210
type: Reaction
product: 783282
fast: false
reversible: false
reactant: 783234
reactant: 783222
product: 783258
reactant: 783246
name: alphaketobutyrate dehydrogenase (mitochondrial)
notes: SUBSYSTEM: Cysteine Metabolism
product: 783270
kinetic law: 783295

831791
kinetic law: 831839
product: 831827
product: 831815
reactant: 831803
notes: GENE_ASSOCIATION: (NM_019036.1 or NM_001042406.1 or NM_000191.2) GENE_LIST: NM_000191.2 NM_001042406.1 NM_019036.1 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: false
name: hydroxymethylglutaryl-CoA lyase, mitochondrial
type: Reaction

825969
stoichiometry: 1.0
species: 765575
type: SpeciesReference

785454
value: 0.0
type: LocalParameter

822249
stoichiometry: 1.0
species: 770985
type: SpeciesReference

813100
stoichiometry: 1.0
species: 770622
type: SpeciesReference

826372
stoichiometry: 1.0
species: 770333
type: SpeciesReference

836896
stoichiometry: 1.0
species: 771636
type: SpeciesReference

852343
value: 1000.0
type: LocalParameter

801381
value: 500.0
type: LocalParameter

832358
stoichiometry: 1.0
species: 769693
type: SpeciesReference

768702
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Pantetheine 4'-phosphate
type: Species

791816
value: 1000.0
type: LocalParameter

846529
value: -1000.0
type: LocalParameter

790348
stoichiometry: 1.0
species: 766604
type: SpeciesReference

783439
value: 0.0
type: LocalParameter

834386
stoichiometry: 1.0
species: 771468
type: SpeciesReference

788310
stoichiometry: 1.0
species: 768800
type: SpeciesReference

767549
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Glucose 1-phosphate
type: Species

775986
stoichiometry: 1.0
species: 765467
type: SpeciesReference

805210
type: Reaction
name: dihydroorotate dehydrogenase (mitochondrial)
product: 805259
product: 805246
reactant: 805234
reactant: 805222
kinetic law: 805271
fast: false
reversible: true
notes: GENE_ASSOCIATION: NM_001025193.1 GENE_LIST: NM_001025193.1 SUBSYSTEM: Nucleotide Metabolism

828154
value: 0.0
type: LocalParameter

851505
reactant: 851529
name: L-serine via sodium symport, blood
product: 851541
reactant: 851517
type: Reaction
reversible: true
product: 851553
fast: false
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_007231.1 or NM_030674.2 or NM_001077484.1 or NM_018976.3) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
kinetic law: 851565

823615
stoichiometry: 1.0
species: 770647
type: SpeciesReference

825643
value: -1000.0
type: LocalParameter

798023
value: 0.0
type: LocalParameter

841874
value: 0.0
type: LocalParameter

809693
stoichiometry: 1.0
species: 766398
type: SpeciesReference

850840
stoichiometry: 1.0
species: 769416
type: SpeciesReference

782424
value: 0.0
type: LocalParameter

833734
value: 0.0
type: LocalParameter

797320
stoichiometry: 1.0
species: 769113
type: SpeciesReference

845779
stoichiometry: 1.0
species: 767779
type: SpeciesReference

844426
stoichiometry: 1.0
species: 766398
type: SpeciesReference

853423
value: -1000.0
type: LocalParameter

846613
stoichiometry: 1.0
species: 771624
type: SpeciesReference

854802
value: 0.0
type: LocalParameter

821115
stoichiometry: 1.0
species: 767440
type: SpeciesReference

823169
value: 0.0
type: LocalParameter

790457
stoichiometry: 1.0
species: 771672
type: SpeciesReference

776701
value: -1.88900999999999E-4
type: LocalParameter

781904
stoichiometry: 1.0
species: 767767
type: SpeciesReference

781044
stoichiometry: 1.0
species: 766338
type: SpeciesReference

808104
stoichiometry: 1.0
species: 766398
type: SpeciesReference

815029
stoichiometry: 7.0
species: 770165
type: SpeciesReference

855759
stoichiometry: 1.0
species: 766398
type: SpeciesReference

782570
stoichiometry: 0.003
species: 767306
type: SpeciesReference

850574
stoichiometry: 1.0
species: 769246
type: SpeciesReference

855214
stoichiometry: 1.0
species: 765804
type: SpeciesReference

793671
kinetic law: 793731
fast: false
product: 793719
reactant: 793695
reactant: 793683
product: 793707
reversible: true
name: eicosatrienoyl carnitine transport (C20:3Crn, n6)
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
type: Reaction

811430
stoichiometry: 1.0
species: 768154
type: SpeciesReference

787708
value: 500.0
type: LocalParameter

810502
value: -1000.0
type: LocalParameter

837925
value: 500.0
type: LocalParameter

792262
stoichiometry: 1.0
species: 770081
type: SpeciesReference

782374
stoichiometry: 1.0
species: 768800
type: SpeciesReference

810393
value: 0.0
type: LocalParameter

806822
stoichiometry: 1.0
species: 765297
type: SpeciesReference

797635
value: 1000.0
type: LocalParameter

765804
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: tetradecanoate (C14:0)
type: Species

839906
value: 1000.0
type: LocalParameter

835398
stoichiometry: 1.0
species: 769549
type: SpeciesReference

792824
kinetic law: 792885
reactant: 792848
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 792873
type: Reaction
product: 792861
fast: false
reversible: true
reactant: 792836
name: carnitine eicosadienoyltransferase (C20:2Crn, n6), mitochondrial

816124
stoichiometry: 7.0
species: 770165
type: SpeciesReference

842128
value: -1000.0
type: LocalParameter

824348
stoichiometry: 1.0
species: 767767
type: SpeciesReference

799257
stoichiometry: 1.0
species: 769669
type: SpeciesReference

812808
value: 0.0
type: LocalParameter

827973
value: 0.0
type: LocalParameter

772960
stoichiometry: 0.01353
species: 769041
type: SpeciesReference

845003
value: 1000.0
type: LocalParameter

814823
stoichiometry: 1.0
species: 770805
type: SpeciesReference

838106
value: 0.0
type: LocalParameter

795693
value: 1000.0
type: LocalParameter

839846
stoichiometry: 1.0
species: 770237
type: SpeciesReference

780537
stoichiometry: 1.0
species: 766204
type: SpeciesReference

773748
kinetic law: 773784
product: 773772
reactant: 773760
fast: false
reversible: true
name: CO2 exchange
type: Reaction

796471
stoichiometry: 1.0
species: 769863
type: SpeciesReference

788964
stoichiometry: 0.001
species: 766736
type: SpeciesReference

833456
value: 0.0
type: LocalParameter

800876
value: 0.0
type: LocalParameter

821001
stoichiometry: 1.0
species: 767440
type: SpeciesReference

841174
value: 0.0
type: LocalParameter

828009
stoichiometry: 1.0
species: 770297
type: SpeciesReference

830901
stoichiometry: 1.0
species: 770429
type: SpeciesReference

827367
stoichiometry: 1.0
species: 770297
type: SpeciesReference

769476
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: trans-2-Methylbut-2-enoyl-CoA
type: Species

818103
stoichiometry: 1.0
species: 770345
type: SpeciesReference

777330
kinetic law: 777366
product: 777354
reactant: 777342
fast: false
reversible: true
name: octadecenoate (C18:1, n-7) exchange
type: Reaction

808861
stoichiometry: 1.0
species: 766338
type: SpeciesReference

803202
value: 1000.0
type: LocalParameter

832986
value: -1000.0
type: LocalParameter

816271
stoichiometry: 9.0
species: 770345
type: SpeciesReference

820772
stoichiometry: 0.03
species: 767839
type: SpeciesReference

848847
stoichiometry: 1.0
species: 767633
type: SpeciesReference

788226
stoichiometry: 1.0
species: 767621
type: SpeciesReference

797538
value: 0.0
type: LocalParameter

782859
stoichiometry: 1.0
species: 766252
type: SpeciesReference

852123
stoichiometry: 1.0
species: 766119
type: SpeciesReference

817090
value: 1000.0
type: LocalParameter

777884
value: 0.0
type: LocalParameter

802528
stoichiometry: 1.0
species: 768323
type: SpeciesReference

855976
value: 0.0
type: LocalParameter

852876
stoichiometry: 1.0
species: 771516
type: SpeciesReference

833144
type: Reaction
kinetic law: 833228
reactant: 833180
name: IMP dehydrogenase
fast: false
product: 833192
reactant: 833156
product: 833216
reactant: 833168
product: 833204
notes: GENE_ASSOCIATION: (NM_183243.1 or NM_000883.2 or NM_001102605.1 or NM_000884.2) GENE_LIST: NM_000883.2 NM_000884.2 NM_001102605.1 NM_183243.1 SUBSYSTEM: Nucleotide Metabolism
reversible: false

843921
stoichiometry: 1.0
species: 769681
type: SpeciesReference

798590
value: -1000.0
type: LocalParameter

820084
reversible: false
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
type: Reaction
product: 820181
reactant: 820109
product: 820157
reactant: 820121
reactant: 820097
kinetic law: 820194
product: 820169
product: 820145
name: fatty acid synthase (n-C6:0)
reactant: 820133
fast: false

854267
stoichiometry: 1.0
species: 767561
type: SpeciesReference

802251
value: 0.0
type: LocalParameter

851371
stoichiometry: 1.0
species: 767767
type: SpeciesReference

838433
stoichiometry: 1.0
species: 769585
type: SpeciesReference

837066
value: 0.0
type: LocalParameter

818468
stoichiometry: 3.0
species: 767767
type: SpeciesReference

819348
value: 500.0
type: LocalParameter

770345
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: H2O
type: Species

819855
value: 0.0
type: LocalParameter

791177
stoichiometry: 1.0
species: 767004
type: SpeciesReference

804171
value: 500.0
type: LocalParameter

799522
stoichiometry: 1.0
species: 769669
type: SpeciesReference

816730
value: 1000.0
type: LocalParameter

824457
name: glyceraldehyde-3-phosphate dehydrogenase (NAD)
product: 824517
kinetic law: 824541
reversible: true
reactant: 824493
notes: GENE_ASSOCIATION: (NM_014364.3 or NM_002046.3) GENE_LIST: NM_002046.3 NM_014364.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reactant: 824481
product: 824505
product: 824529
reactant: 824469
type: Reaction

812917
stoichiometry: 1.0
species: 770622
type: SpeciesReference

851481
value: 0.0
type: LocalParameter

835035
stoichiometry: 1.0
species: 768142
type: SpeciesReference

782265
value: 0.0
type: LocalParameter

797744
value: -1000.0
type: LocalParameter

843061
value: 1000.0
type: LocalParameter

806713
kinetic law: 806750
product: 806737
reactant: 806725
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: eicosanoate transport (n-C20:0), cytosol to blood
type: Reaction

854473
kinetic law: 854534
product: 854509
notes: GENE_ASSOCIATION: NM_001071.1 GENE_LIST: NM_001071.1 SUBSYSTEM: Nucleotide Metabolism
type: Reaction
name: thymidylate synthase
reversible: true
product: 854522
fast: false
reactant: 854497
reactant: 854485

852768
value: 0.0
type: LocalParameter

803626
stoichiometry: 1.0
species: 768323
type: SpeciesReference

788116
stoichiometry: 2.0
species: 771732
type: SpeciesReference

827476
value: 1000.0
type: LocalParameter

829101
value: 0.0
type: LocalParameter

848787
stoichiometry: 1.0
species: 767464
type: SpeciesReference

780646
value: 500.0
type: LocalParameter

767779
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: H2O
type: Species

769585
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: (S)-3-Methyl-2-oxopentanoate
type: Species

774474
value: 0.0
type: LocalParameter

848127
value: 0.0
type: LocalParameter

793935
stoichiometry: 1.0
species: 770007
type: SpeciesReference

767476
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: S-Formylglutathione
type: Species

800333
value: 0.0
type: LocalParameter

824699
value: 1000.0
type: LocalParameter

833035
kinetic law: 833084
product: 833072
reactant: 833059
reactant: 833047
notes: GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: true
name: IMP cyclohydrolase
type: Reaction

813332
stoichiometry: 1.0
species: 769899
type: SpeciesReference

773639
value: 500.0
type: LocalParameter

850260
value: 0.0
type: LocalParameter

777775
value: 1000.0
type: LocalParameter

832080
value: 0.0
type: LocalParameter

814412
stoichiometry: 1.0
species: 770153
type: SpeciesReference

809946
value: 0.0
type: LocalParameter

781611
value: 0.0
type: LocalParameter

765225
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: docosahexaenoate (C22:6, n-3)
type: Species

799147
stoichiometry: 1.0
species: 770913
type: SpeciesReference

791021
stoichiometry: 1.0
species: 766980
type: SpeciesReference

838324
stoichiometry: 1.0
species: 769839
type: SpeciesReference

782703
stoichiometry: 0.003
species: 768739
type: SpeciesReference

802636
stoichiometry: 1.0
species: 768335
type: SpeciesReference

843641
stoichiometry: 1.0
species: 768690
type: SpeciesReference

790204
value: 1000.0
type: LocalParameter

848507
stoichiometry: 1.0
species: 766288
type: SpeciesReference

834982
value: 1000.0
type: LocalParameter

855420
stoichiometry: 1.0
species: 769318
type: SpeciesReference

820496
stoichiometry: 1.0
species: 766604
type: SpeciesReference

854376
stoichiometry: 1.0
species: 766240
type: SpeciesReference

819746
stoichiometry: 1.0
species: 768154
type: SpeciesReference

831683
stoichiometry: 1.0
species: 768298
type: SpeciesReference

802035
value: 1000.0
type: LocalParameter

785250
stoichiometry: 1.0
species: 766374
type: SpeciesReference

807491
value: 0.0
type: LocalParameter

799401
stoichiometry: 1.0
species: 766216
type: SpeciesReference

834278
stoichiometry: 1.0
species: 768118
type: SpeciesReference

811201
stoichiometry: 0.003
species: 768409
type: SpeciesReference

853651
stoichiometry: 1.0
species: 767100
type: SpeciesReference

770057
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosenoyl-CoA (C20:1CoA, n-11)
type: Species

829994
stoichiometry: 1.0
species: 770333
type: SpeciesReference

785105
stoichiometry: 1.0
species: 766350
type: SpeciesReference

805102
stoichiometry: 1.0
species: 767767
type: SpeciesReference

778924
value: 0.0
type: LocalParameter

838975
stoichiometry: 1.0
species: 770634
type: SpeciesReference

830707
value: 1000.0
type: LocalParameter

819963
stoichiometry: 1.0
species: 766604
type: SpeciesReference

809089
value: 0.0
type: LocalParameter

840378
value: -1000.0
type: LocalParameter

792104
stoichiometry: 1.0
species: 769863
type: SpeciesReference

766956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Dephospho-CoA
type: Species

842261
value: 0.0
type: LocalParameter

827743
stoichiometry: 1.0
species: 766398
type: SpeciesReference

822357
stoichiometry: 1.0
species: 769198
type: SpeciesReference

842698
value: 500.0
type: LocalParameter

825752
value: 1000.0
type: LocalParameter

851614
value: 0.0
type: LocalParameter

817910
stoichiometry: 1.0
species: 770345
type: SpeciesReference

844534
value: 500.0
type: LocalParameter

853507
stoichiometry: 1.0
species: 771119
type: SpeciesReference

806388
value: 0.0
type: LocalParameter

828045
value: 1000.0
type: LocalParameter

778029
stoichiometry: 1.0
species: 772430
type: SpeciesReference

828907
stoichiometry: 1.0
species: 767779
type: SpeciesReference

829658
value: -1000.0
type: LocalParameter

788467
stoichiometry: 3.0
species: 770333
type: SpeciesReference

791707
value: 0.0
type: LocalParameter

839616
stoichiometry: 1.0
species: 767767
type: SpeciesReference

840981
reactant: 840993
fast: false
reactant: 841005
notes: GENE_ASSOCIATION: NM_014595.1 GENE_LIST: NM_014595.1 SUBSYSTEM: Nucleotide Metabolism
kinetic law: 841042
reversible: false
product: 841017
type: Reaction
name: 5'-nucleotidase (dTMP)
product: 841030

841764
stoichiometry: 1.0
species: 769754
type: SpeciesReference

832201
name: 4-hydroxyphenylpyruvate dioxygenase
reversible: false
kinetic law: 832261
product: 832249
fast: false
type: Reaction
reactant: 832225
product: 832237
notes: GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Tyrosine metabolism
reactant: 832213

783548
value: 0.0
type: LocalParameter

776386
stoichiometry: 1.0
species: 772226
type: SpeciesReference

846722
stoichiometry: 1.0
species: 768849
type: SpeciesReference

815450
value: 1000.0
type: LocalParameter

811889
stoichiometry: 1.0
species: 767343
type: SpeciesReference

800984
value: 0.0
type: LocalParameter

826590
value: 1000.0
type: LocalParameter

835641
value: 0.0
type: LocalParameter

767100
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Erythrose 4-phosphate
type: Species

795981
stoichiometry: 1.0
species: 766628
type: SpeciesReference

793078
stoichiometry: 1.0
species: 766628
type: SpeciesReference

778005
kinetic law: 778041
product: 778029
reactant: 778017
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

783803
value: 1000.0
type: LocalParameter

824228
stoichiometry: 1.0
species: 766386
type: SpeciesReference

847350
stoichiometry: 1.0
species: 771046
type: SpeciesReference

786000
stoichiometry: 1.0
species: 766652
type: SpeciesReference

814072
stoichiometry: 1.0
species: 770381
type: SpeciesReference

792543
value: 1000.0
type: LocalParameter

819625
stoichiometry: 1.0
species: 767779
type: SpeciesReference

850683
product: 850720
type: Reaction
name: ribonucleoside-diphosphate reductase (UDP)
product: 850732
reactant: 850708
fast: false
kinetic law: 850756
product: 850744
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotide Metabolism
reversible: false
reactant: 850696

810285
stoichiometry: 1.0
species: 766616
type: SpeciesReference

798360
value: 1000.0
type: LocalParameter

786193
value: 0.0
type: LocalParameter

777956
value: -1000.0
type: LocalParameter

774256
stoichiometry: 1.0
species: 771960
type: SpeciesReference

835254
value: 0.0
type: LocalParameter

808417
stoichiometry: 1.0
species: 767972
type: SpeciesReference

774317
value: 500.0
type: LocalParameter

831467
stoichiometry: 1.0
species: 769851
type: SpeciesReference

771021
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Propionate
type: Species

782871
stoichiometry: 1.0
species: 767779
type: SpeciesReference

767997
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: heptadecenoyl CoA (C17:1CoA, n-8)
type: Species

786447
value: 0.0
type: LocalParameter

766398
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ATP
type: Species

797963
stoichiometry: 1.0
species: 770913
type: SpeciesReference

777221
value: 500.0
type: LocalParameter

770683
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: nonanoyl-CoA (C9:0CoA)
type: Species

822696
value: 500.0
type: LocalParameter

849489
stoichiometry: 1.0
species: 769041
type: SpeciesReference

769367
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Uridine
type: Species

803844
value: 0.0
type: LocalParameter

776167
kinetic law: 776205
product: 776192
reactant: 776179
fast: false
reversible: true
name: heptadecanoate (C17:0) exchange
type: Reaction

791441
value: -1000.0
type: LocalParameter

840631
value: 1000.0
type: LocalParameter

767695
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: glycogen
type: Species

787297
stoichiometry: 1.0
species: 771528
type: SpeciesReference

854692
product: 854753
reactant: 854704
name: thioredoxin reductase (NADPH)
type: Reaction
reactant: 854716
notes: GENE_ASSOCIATION: (NM_182729.1 or NM_003330.2 or NM_182742.1 or NM_182743.1 or NM_001093771.1) GENE_LIST: NM_001093771.1 NM_003330.2 NM_182729.1 NM_182742.1 NM_182743.1 SUBSYSTEM: Tyrosine metabolism
reactant: 854728
fast: false
reversible: true
kinetic law: 854766
product: 854740

800552
stoichiometry: 1.0
species: 766664
type: SpeciesReference

808561
stoichiometry: 1.0
species: 768397
type: SpeciesReference

837176
value: 0.0
type: LocalParameter

847133
stoichiometry: 1.0
species: 768885
type: SpeciesReference

836400
stoichiometry: 1.0
species: 768885
type: SpeciesReference

822829
stoichiometry: 1.0
species: 767537
type: SpeciesReference

845451
value: -1000.0
type: LocalParameter

782048
value: 0.0
type: LocalParameter

794886
stoichiometry: 1.0
species: 766628
type: SpeciesReference

856323
value: 0.0
type: LocalParameter

833892
value: 0.0
type: LocalParameter

816597
stoichiometry: 10.0
species: 769851
type: SpeciesReference

827042
stoichiometry: 1.0
species: 770333
type: SpeciesReference

805660
value: 0.0
type: LocalParameter

809259
stoichiometry: 1.0
species: 766398
type: SpeciesReference

796361
stoichiometry: 1.0
species: 768520
type: SpeciesReference

800405
stoichiometry: 1.0
species: 767779
type: SpeciesReference

801503
value: 500.0
type: LocalParameter

841426
value: 0.0
type: LocalParameter

816403
product: 816500
reactant: 816427
product: 816488
reactant: 816464
product: 816476
fast: false
reversible: false
name: Beta oxidation of fatty acid
reactant: 816415
kinetic law: 816524
type: Reaction
product: 816512
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_014049.3 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_0... GENE_LIST: NM_0... NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 816439
reactant: 816452

804583
stoichiometry: 1.0
species: 768323
type: SpeciesReference

821557
value: 0.0
type: LocalParameter

818358
stoichiometry: 1.0
species: 770333
type: SpeciesReference

814630
stoichiometry: 8.0
species: 770622
type: SpeciesReference

838543
value: 0.0
type: LocalParameter

799742
value: 500.0
type: LocalParameter

775201
kinetic law: 775237
product: 775225
reactant: 775213
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

772262
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: lys_L_b
type: Species

849065
product: 849113
product: 849125
notes: GENE_ASSOCIATION: (NM_002764.2 or NM_001039091.1 or NM_002765.3 or NM_175886.2) GENE_LIST: NM_001039091.1 NM_002764.2 NM_002765.3 NM_175886.2 SUBSYSTEM: Nucleotide Metabolism
product: 849101
reversible: true
reactant: 849089
kinetic law: 849137
type: Reaction
reactant: 849077
fast: false
name: phosphoribosylpyrophosphate synthetase

783766
stoichiometry: 1.0
species: 768286
type: SpeciesReference

794308
stoichiometry: 1.0
species: 769851
type: SpeciesReference

790781
stoichiometry: 1.0
species: 766628
type: SpeciesReference

780984
notes: GENE_ASSOCIATION: (NM_139274.1 or NM_018677.2 or NM_023928.2) GENE_LIST: NM_018677.2 NM_023928.2 NM_139274.1 SUBSYSTEM: Pyruvate Metabolism
fast: false
product: 781044
reactant: 780996
type: Reaction
reactant: 781008
product: 781056
name: acetyl-CoA synthetase
reactant: 781020
product: 781032
kinetic law: 781068
reversible: false

850116
value: 0.0
type: LocalParameter

778187
value: 500.0
type: LocalParameter

812167
value: 500.0
type: LocalParameter

846300
value: 1000.0
type: LocalParameter

840764
value: 0.0
type: LocalParameter

783950
value: 0.0
type: LocalParameter

821876
stoichiometry: 1.0
species: 766071
type: SpeciesReference

813039
value: 500.0
type: LocalParameter

783101
stoichiometry: 1.0
species: 766288
type: SpeciesReference

822128
value: -1000.0
type: LocalParameter

790673
stoichiometry: 1.0
species: 769911
type: SpeciesReference

810658
value: 1000.0
type: LocalParameter

813552
stoichiometry: 6.0
species: 770634
type: SpeciesReference

805320
value: 0.0
type: LocalParameter

824048
value: 1000.0
type: LocalParameter

787828
value: 0.0
type: LocalParameter

855105
stoichiometry: 1.0
species: 765792
type: SpeciesReference

827524
stoichiometry: 1.0
species: 767670
type: SpeciesReference

775417
stoichiometry: 1.0
species: 772104
type: SpeciesReference

828859
value: 0.0
type: LocalParameter

774862
value: 0.0
type: LocalParameter

779256
value: -1000.0
type: LocalParameter

844318
stoichiometry: 1.0
species: 769657
type: SpeciesReference

785031
value: 0.0
type: LocalParameter

779521
value: 0.0
type: LocalParameter

853723
value: 0.0
type: LocalParameter

810067
value: -1000.0
type: LocalParameter

788686
stoichiometry: 1.0
species: 770309
type: SpeciesReference

765684
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: ocosatetraenoate (C22:4, n-6)
type: Species

845149
value: 0.0
type: LocalParameter

793355
stoichiometry: 1.0
species: 770141
type: SpeciesReference

775610
stoichiometry: 1.0
species: 772116
type: SpeciesReference

791924
value: -1000.0
type: LocalParameter

787588
stoichiometry: 1.0
species: 771492
type: SpeciesReference

798918
stoichiometry: 1.0
species: 769863
type: SpeciesReference

768921
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Proline
type: Species

832503
stoichiometry: 1.0
species: 766604
type: SpeciesReference

795837
value: 0.0
type: LocalParameter

798143
value: 0.0
type: LocalParameter

846940
value: 500.0
type: LocalParameter

838759
value: -1000.0
type: LocalParameter

807051
stoichiometry: 1.0
species: 768776
type: SpeciesReference

771432
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: D-Glucose
type: Species

845888
stoichiometry: 1.0
species: 768788
type: SpeciesReference

843169
value: -1000.0
type: LocalParameter

790565
stoichiometry: 1.0
species: 766616
type: SpeciesReference

772660
stoichiometry: 2.3E-5
species: 766640
type: SpeciesReference

769125
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: stearidonyl coenzyme A (C18:4CoA, n-3)
type: Species

768409
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoate (C18:1, n-5)
type: Species

820628
stoichiometry: 0.001
species: 767404
type: SpeciesReference

825861
stoichiometry: 1.0
species: 767767
type: SpeciesReference

823386
value: -1000.0
type: LocalParameter

794104
value: -1000.0
type: LocalParameter

830093
stoichiometry: 1.0
species: 765430
type: SpeciesReference

805974
stoichiometry: 1.0
species: 771648
type: SpeciesReference

822502
stoichiometry: 1.0
species: 768142
type: SpeciesReference

843799
stoichiometry: 1.0
species: 768885
type: SpeciesReference

800760
kinetic law: 800826
product: 800799
notes: GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reactant: 800773
reactant: 800786
name: cytidylate kinase (CMP)
product: 800813
type: Reaction
reversible: true

845331
stoichiometry: 1.0
species: 771444
type: SpeciesReference

837370
value: 0.0
type: LocalParameter

773096
stoichiometry: 8.91E-4
species: 768885
type: SpeciesReference

787936
value: 0.0
type: LocalParameter

772370
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ocdctra3_b
type: Species

775769
value: 500.0
type: LocalParameter

831275
reactant: 831311
reactant: 831287
kinetic law: 831359
product: 831347
name: Hydroxymethylglutaryl CoA synthase
product: 831323
type: Reaction
notes: GENE_ASSOCIATION: (NM_001098272.1 or NM_002130.4) GENE_LIST: NM_001098272.1 NM_002130.4 SUBSYSTEM: Cholesterol Metabolism
product: 831335
fast: false
reversible: false
reactant: 831299

790096
value: 0.0
type: LocalParameter

810176
stoichiometry: 1.0
species: 767355
type: SpeciesReference

812095
stoichiometry: 4.0
species: 768323
type: SpeciesReference

771588
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: zymosterone
type: Species

822939
reactant: 822951
product: 822975
notes: SUBSYSTEM: Vitamins & Cofactor Biosynthesis
reversible: false
product: 822987
reactant: 822963
kinetic law: 822999
type: Reaction
fast: false
name: Formaldehyde activation (spontaneous)

778705
stoichiometry: 1.0
species: 772515
type: SpeciesReference

853206
type: Reaction
product: 853242
kinetic law: 853266
reactant: 853230
fast: false
product: 853254
notes: GENE_ASSOCIATION: (NM_001035511.1 or NM_001035512.1 or NM_001035513.1) GENE_LIST: NM_001035511.1 NM_001035512.1 NM_001035513.1 SUBSYSTEM: Oxidative Phosphorylation
name: succinate dehydrogenase cytochrome b
reactant: 853218
reversible: true

776278
stoichiometry: 1.0
species: 765503
type: SpeciesReference

843217
notes: GENE_ASSOCIATION: (NM_003748.2 or NM_170726.1) GENE_LIST: NM_003748.2 NM_170726.1 SUBSYSTEM: Arginine and Proline Metabolism
type: Reaction
reactant: 843253
reactant: 843241
kinetic law: 843301
product: 843277
product: 843265
fast: false
reversible: false
product: 843289
reactant: 843229
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

808849
stoichiometry: 1.0
species: 768421
type: SpeciesReference

774971
value: 1000.0
type: LocalParameter

780392
value: 0.0
type: LocalParameter

820604
value: 500.0
type: LocalParameter

793635
value: 1000.0
type: LocalParameter

780247
value: 1000.0
type: LocalParameter

834410
stoichiometry: 3.0
species: 771540
type: SpeciesReference

810935
value: -1000.0
type: LocalParameter

845997
stoichiometry: 1.0
species: 766592
type: SpeciesReference

823507
value: -1000.0
type: LocalParameter

826152
value: 1000.0
type: LocalParameter

791597
value: 0.0
type: LocalParameter

846831
kinetic law: 846892
product: 846880
reactant: 846843
fast: false
notes: GENE_ASSOCIATION: NM_021095.1 GENE_LIST: NM_021095.1 SUBSYSTEM: Transport, Extracellular
product: 846868
name: Pantothenate sodium symporter, blood
type: Reaction
reactant: 846855
reversible: false

811768
value: 0.0
type: LocalParameter

825414
stoichiometry: 1.0
species: 770309
type: SpeciesReference

856037
stoichiometry: 1.0
species: 768034
type: SpeciesReference

843361
type: Reaction
reactant: 843374
kinetic law: 843435
reactant: 843397
fast: false
notes: GENE_ASSOCIATION: (NM_013328.2 or NM_023078.1) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Proline Metabolism
product: 843423
reactant: 843385
product: 843410
reversible: false
name: pyrroline-5-carboxylate reductase

765575
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Sodium
type: Species

799898
value: 500.0
type: LocalParameter

843629
kinetic law: 843665
product: 843653
reactant: 843641
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: phosphatidate reversible transport, mitochondrial, adipocyte
type: Reaction

777667
value: -0.0068668641
type: LocalParameter

770792
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecenoyl-CoA (C18:1CoA, n-5)
type: Species

815342
stoichiometry: 8.0
species: 770345
type: SpeciesReference

836556
value: -1000.0
type: LocalParameter

769258
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: triglyceride, human adipoctye
type: Species

850405
value: 500.0
type: LocalParameter

788746
value: -1000.0
type: LocalParameter

772817
stoichiometry: 0.004687
species: 767924
type: SpeciesReference

803420
stoichiometry: 1.0
species: 768335
type: SpeciesReference

806605
value: 0.0
type: LocalParameter

786338
notes: SUBSYSTEM: Transport, Peroxisomal
reversible: true
fast: false
reactant: 786350
type: Reaction
name: ATP/ADP transport, peroxisome
kinetic law: 786398
product: 786374
product: 786386
reactant: 786362

829802
value: 1000.0
type: LocalParameter

837285
value: 1000.0
type: LocalParameter

805550
value: 1000.0
type: LocalParameter

836618
stoichiometry: 1.0
species: 766083
type: SpeciesReference

777113
value: 0.0
type: LocalParameter

814981
stoichiometry: 8.0
species: 770345
type: SpeciesReference

844895
value: 0.0
type: LocalParameter

789910
kinetic law: 789949
product: 789936
reactant: 789923
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: cardiolipin reversible transport, mitochondria, adipocyte
type: Reaction

805889
value: 0.0
type: LocalParameter

782156
value: 0.0
type: LocalParameter

838651
value: 1000.0
type: LocalParameter

802324
value: 1000.0
type: LocalParameter

777052
stoichiometry: 1.0
species: 765599
type: SpeciesReference

840523
value: 0.0
type: LocalParameter

816838
stoichiometry: 11.0
species: 769657
type: SpeciesReference

845560
value: 1000.0
type: LocalParameter

841318
value: 1000.0
type: LocalParameter

854049
value: -1000.0
type: LocalParameter

796251
stoichiometry: 1.0
species: 766628
type: SpeciesReference

801165
stoichiometry: 1.0
species: 766592
type: SpeciesReference

771864
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: asn_L_b
type: Species

821448
value: 0.0
type: LocalParameter

781769
stoichiometry: 1.0
species: 768885
type: SpeciesReference

818249
value: 500.0
type: LocalParameter

788008
stoichiometry: 2.0
species: 770345
type: SpeciesReference

848629
stoichiometry: 1.0
species: 766386
type: SpeciesReference

789097
stoichiometry: 1.0
species: 766470
type: SpeciesReference

796579
name: octadecatrienoyl carnitine transferase (C18:3Crn, n3)
reactant: 796591
product: 796629
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 796641
fast: false
type: Reaction
product: 796616
reactant: 796603
reversible: true

831575
stoichiometry: 1.0
species: 767936
type: SpeciesReference

781346
value: -1000.0
type: LocalParameter

766046
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
type: Species

815920
stoichiometry: 9.0
species: 770622
type: SpeciesReference

801939
reversible: false
fast: false
name: dCMP deaminase
notes: GENE_ASSOCIATION: (NM_001921.2 or NM_001012732.1) GENE_LIST: NM_001012732.1 NM_001921.2 SUBSYSTEM: Nucleotide Metabolism
product: 801987
type: Reaction
product: 801999
reactant: 801963
kinetic law: 802011
reactant: 801951
reactant: 801975

788892
value: 0.0
type: LocalParameter

809368
value: 0.0
type: LocalParameter

830611
value: 500.0
type: LocalParameter

833746
value: 500.0
type: LocalParameter

855201
stoichiometry: 1.0
species: 769294
type: SpeciesReference

809681
type: Reaction
product: 809730
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_004457.3 or NM_203372.1 or NM_022977.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reactant: 809693
fast: false
product: 809754
product: 809742
reversible: true
reactant: 809705
kinetic law: 809766
reactant: 809718
name: fatty-acid--CoA ligase (eicosenoate, C20:1 n-9)

841862
value: 0.0
type: LocalParameter

782436
value: 500.0
type: LocalParameter

848641
stoichiometry: 1.0
species: 766398
type: SpeciesReference

854814
value: 0.0
type: LocalParameter

846601
stoichiometry: 1.0
species: 771660
type: SpeciesReference

844438
stoichiometry: 1.0
species: 767392
type: SpeciesReference

807039
stoichiometry: 1.0
species: 767779
type: SpeciesReference

790445
stoichiometry: 1.0
species: 766604
type: SpeciesReference

797332
stoichiometry: 1.0
species: 769863
type: SpeciesReference

853435
value: 1000.0
type: LocalParameter

775829
value: 0.0
type: LocalParameter

815017
stoichiometry: 9.0
species: 769657
type: SpeciesReference

808116
stoichiometry: 1.0
species: 766616
type: SpeciesReference

845671
value: 0.0
type: LocalParameter

828316
value: 0.0
type: LocalParameter

782582
stoichiometry: 0.004
species: 767355
type: SpeciesReference

850586
stoichiometry: 1.0
species: 766724
type: SpeciesReference

786290
value: -1000.0
type: LocalParameter

787840
value: 1000.0
type: LocalParameter

832647
stoichiometry: 1.0
species: 770659
type: SpeciesReference

779111
stoichiometry: 1.0
species: 768335
type: SpeciesReference

781056
stoichiometry: 1.0
species: 768885
type: SpeciesReference

806924
stoichiometry: 1.0
species: 765309
type: SpeciesReference

854061
value: 1000.0
type: LocalParameter

837913
value: 0.0
type: LocalParameter

821128
stoichiometry: 1.0
species: 767779
type: SpeciesReference

834518
value: 500.0
type: LocalParameter

772092
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: gly_b
type: Species

783319
value: 1000.0
type: LocalParameter

790769
product: 790805
type: Reaction
product: 790817
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_152245.1 or NM_152246.1 or NM_001876.2 or NM_152359.1 or NM_004377.2 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine docosenoyltransferase (C22:1Crn, n9)
reversible: true
reactant: 790781
fast: false
kinetic law: 790829
reactant: 790793

794596
value: 1000.0
type: LocalParameter

813479
stoichiometry: 6.0
species: 770345
type: SpeciesReference

840499
value: -1000.0
type: LocalParameter

835760
value: 1000.0
type: LocalParameter

852331
value: 0.0
type: LocalParameter

825957
stoichiometry: 1.0
species: 765357
type: SpeciesReference

826360
stoichiometry: 1.0
species: 769693
type: SpeciesReference

784168
stoichiometry: 2.0
species: 767767
type: SpeciesReference

784095
value: 500.0
type: LocalParameter

792689
value: 0.0
type: LocalParameter

785466
value: 0.0
type: LocalParameter

775974
kinetic law: 776010
product: 775998
reactant: 775986
fast: false
reversible: true
name: hexadecenoate (C16:1, n-9) exchange
type: Reaction

768714
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Phosphatidylcholine, human adipoctye
type: Species

829270
value: -1000.0
type: LocalParameter

791828
value: 0.0
type: LocalParameter

813113
stoichiometry: 1.0
species: 771204
type: SpeciesReference

783427
value: 0.0
type: LocalParameter

834398
stoichiometry: 3.0
species: 771528
type: SpeciesReference

851517
stoichiometry: 1.0
species: 765575
type: SpeciesReference

803408
stoichiometry: 1.0
species: 767767
type: SpeciesReference

801394
reactant: 801406
notes: GENE_ASSOCIATION: (NM_177414.1 or NM_177526.1 or NM_003713.3 or NM_176895.1 or NM_003712.2 or NM_003711.2 or NM_177543.1) GENE_LIST: NM_003711.2 NM_003712.2 NM_003713.3 NM_176895.1 NM_177414.1 NM_177526.1 NM_177543.1 SUBSYSTEM: Phospholipid Metabolism
reactant: 801418
product: 801443
name: diacylglycerol pyrophosphate phosphatase, human adipocyte
reversible: false
kinetic law: 801455
fast: false
type: Reaction
product: 801430

798011
value: 0.0
type: LocalParameter

830829
value: -1000.0
type: LocalParameter

805222
stoichiometry: 1.0
species: 766932
type: SpeciesReference

823603
stoichiometry: 1.0
species: 770285
type: SpeciesReference

828142
value: 1000.0
type: LocalParameter

838446
stoichiometry: 1.0
species: 769851
type: SpeciesReference

848859
stoichiometry: 2.0
species: 767767
type: SpeciesReference

790997
value: 0.0
type: LocalParameter

820784
stoichiometry: 0.005
species: 767851
type: SpeciesReference

816283
stoichiometry: 9.0
species: 770622
type: SpeciesReference

852864
stoichiometry: 1.0
species: 771348
type: SpeciesReference

789607
reactant: 789631
product: 789667
kinetic law: 789703
fast: false
name: Citrate lyase (ATP-requiring)
notes: GENE_ASSOCIATION: (NM_198830.1 or NM_001096.2) GENE_LIST: NM_001096.2 NM_198830.1 SUBSYSTEM: Central Metabolism
reversible: false
product: 789691
product: 789655
product: 789679
reactant: 789643
type: Reaction
reactant: 789619

833156
stoichiometry: 1.0
species: 767779
type: SpeciesReference

817199
stoichiometry: 11.0
species: 769657
type: SpeciesReference

777872
value: 0.0
type: LocalParameter

788214
stoichiometry: 2.0
species: 766398
type: SpeciesReference

852111
notes: GENE_ASSOCIATION: NM_003124.3 GENE_LIST: NM_003124.3 SUBSYSTEM: Folate Metabolism
kinetic law: 852185
name: sepiapterin reductase, reversible
fast: false
reactant: 852123
product: 852160
reactant: 852148
reactant: 852136
product: 852172
reversible: true
type: Reaction

802516
stoichiometry: 2.0
species: 767779
type: SpeciesReference

855988
product: 856037
name: uridine kinase (ITP:Uridine)
reversible: false
reactant: 856012
reactant: 856000
product: 856024
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_031432.1 or NM_012474.3) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
product: 856050
kinetic law: 856063

782847
name: adenosylhomocysteinase
reactant: 782859
reversible: true
product: 782896
reactant: 782871
type: Reaction
product: 782883
kinetic law: 782908
notes: GENE_ASSOCIATION: (NM_006621.3 or NM_015328.1 or NM_000687.1) GENE_LIST: NM_000687.1 NM_006621.3 NM_015328.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
fast: false

802263
kinetic law: 802299
product: 802287
reactant: 802275
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Docosapentaenoate (C22:5, n-3)
type: Reaction

855541
stoichiometry: 1.0
species: 766300
type: SpeciesReference

819867
value: 1000.0
type: LocalParameter

794741
value: 0.0
type: LocalParameter

782060
value: 0.0
type: LocalParameter

820072
value: 500.0
type: LocalParameter

770333
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: H+
type: Species

770610
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: (S)-Methylmalonyl-CoA
type: Species

847691
value: 500.0
type: LocalParameter

818456
reactant: 818505
reactant: 818493
name: fatty acid synthase (n-C10:0)
kinetic law: 818577
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
product: 818541
product: 818565
product: 818529
fast: false
type: Reaction
product: 818553
reactant: 818468
reversible: false
product: 818517
reactant: 818481

811321
stoichiometry: 0.001
species: 767416
type: SpeciesReference

837054
value: 1000.0
type: LocalParameter

835386
product: 835459
name: methylcrotonoyl-CoA carboxylase, mitochondrial
product: 835471
reversible: false
reactant: 835398
type: Reaction
reactant: 835410
kinetic law: 835483
reactant: 835422
fast: false
notes: GENE_ASSOCIATION: (NM_020166.2 and NM_022132.3) GENE_LIST: NM_020166.2 NM_022132.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
product: 835434
product: 835446

792836
stoichiometry: 1.0
species: 769863
type: SpeciesReference

772358
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ocdcea9_b
type: Species

814836
stoichiometry: 9.0
species: 769657
type: SpeciesReference

810381
value: 0.0
type: LocalParameter

806810
kinetic law: 806846
product: 806834
reactant: 806822
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Eicosatrienoate (C20:3, n-6) transport
type: Reaction

765816
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: tetradecenoate (C14:1, n-5)
type: Species

797623
value: -1000.0
type: LocalParameter

827961
value: 0.0
type: LocalParameter

847496
stoichiometry: 1.0
species: 768702
type: SpeciesReference

851384
stoichiometry: 1.0
species: 768825
type: SpeciesReference

836763
stoichiometry: 1.0
species: 765575
type: SpeciesReference

823903
value: 0.0
type: LocalParameter

799269
stoichiometry: 1.0
species: 769851
type: SpeciesReference

802119
value: -1000.0
type: LocalParameter

780549
stoichiometry: 1.0
species: 767779
type: SpeciesReference

809802
value: 0.0
type: LocalParameter

833444
value: 1000.0
type: LocalParameter

773736
value: 0.0
type: LocalParameter

814109
stoichiometry: 6.0
species: 770165
type: SpeciesReference

771009
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Palmitoylcarnitine (C16:0Crn)
type: Species

767331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Ethanol
type: Species

796483
stoichiometry: 1.0
species: 770768
type: SpeciesReference

816137
stoichiometry: 9.0
species: 770333
type: SpeciesReference

788976
stoichiometry: 1.0
species: 767767
type: SpeciesReference

838118
value: 0.0
type: LocalParameter

839834
stoichiometry: 1.0
species: 769730
type: SpeciesReference

840619
value: -1000.0
type: LocalParameter

821013
stoichiometry: 1.0
species: 766895
type: SpeciesReference

800864
value: 0.0
type: LocalParameter

769488
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 2-Methylbutanoyl-CoA
type: Species

830913
stoichiometry: 1.0
species: 769537
type: SpeciesReference

827379
stoichiometry: 1.0
species: 770622
type: SpeciesReference

841186
value: 1000.0
type: LocalParameter

777763
value: 0.0
type: LocalParameter

850272
value: 500.0
type: LocalParameter

819204
stoichiometry: 1.0
species: 768154
type: SpeciesReference

833047
stoichiometry: 1.0
species: 767779
type: SpeciesReference

818116
stoichiometry: 1.0
species: 770622
type: SpeciesReference

813320
stoichiometry: 1.0
species: 769657
type: SpeciesReference

854460
value: 500.0
type: LocalParameter

765213
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: docosenoate (C22:1, n-9)
type: Species

796591
stoichiometry: 1.0
species: 768544
type: SpeciesReference

790216
value: 0.0
type: LocalParameter

814424
stoichiometry: 1.0
species: 770345
type: SpeciesReference

809958
value: 0.0
type: LocalParameter

841030
stoichiometry: 1.0
species: 769222
type: SpeciesReference

838337
stoichiometry: 1.0
species: 770477
type: SpeciesReference

799159
stoichiometry: 1.0
species: 769863
type: SpeciesReference

843653
stoichiometry: 1.0
species: 770901
type: SpeciesReference

802624
stoichiometry: 1.0
species: 767767
type: SpeciesReference

818565
stoichiometry: 2.0
species: 768323
type: SpeciesReference

802047
value: 0.0
type: LocalParameter

842539
value: -1000.0
type: LocalParameter

791033
stoichiometry: 1.0
species: 769863
type: SpeciesReference

820339
stoichiometry: 1.0
species: 767779
type: SpeciesReference

819758
stoichiometry: 2.0
species: 768335
type: SpeciesReference

820181
stoichiometry: 2.0
species: 768323
type: SpeciesReference

831695
stoichiometry: 1.0
species: 767476
type: SpeciesReference

855432
stoichiometry: 1.0
species: 766131
type: SpeciesReference

854388
stoichiometry: 1.0
species: 767052
type: SpeciesReference

849617
value: -1000.0
type: LocalParameter

820484
stoichiometry: 2.0
species: 768335
type: SpeciesReference

835108
value: 1000.0
type: LocalParameter

799534
stoichiometry: 1.0
species: 769863
type: SpeciesReference

824469
stoichiometry: 1.0
species: 767561
type: SpeciesReference

851493
value: 500.0
type: LocalParameter

812929
stoichiometry: 1.0
species: 769657
type: SpeciesReference

765708
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Phosphate
type: Species

838228
value: 0.0
type: LocalParameter

808008
stoichiometry: 1.0
species: 767864
type: SpeciesReference

806701
value: 0.0
type: LocalParameter

835495
value: 0.0
type: LocalParameter

771119
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Succinate
type: Species

782277
value: 0.0
type: LocalParameter

835048
stoichiometry: 1.0
species: 769693
type: SpeciesReference

769597
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 4-Methyl-2-oxopentanoate
type: Species

803638
stoichiometry: 1.0
species: 768532
type: SpeciesReference

827488
value: 0.0
type: LocalParameter

771720
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: H+
type: Species

788104
stoichiometry: 2.0
species: 771744
type: SpeciesReference

767767
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: H+
type: Species

800345
value: 1000.0
type: LocalParameter

829113
value: 500.0
type: LocalParameter

769270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Tryptophan
type: Species

848799
stoichiometry: 1.0
species: 767621
type: SpeciesReference

789836
stoichiometry: 1.0
species: 770333
type: SpeciesReference

773627
value: 0.0
type: LocalParameter

780658
kinetic law: 780730
fast: false
name: acetyl-CoA hydrolase, mitochondrial
reactant: 780682
product: 780718
product: 780706
product: 780694
notes: SUBSYSTEM: Pyruvate Metabolism
reversible: false
type: Reaction
reactant: 780670

786897
stoichiometry: 1.0
species: 771444
type: SpeciesReference

848139
value: 500.0
type: LocalParameter

774486
value: 1000.0
type: LocalParameter

793947
stoichiometry: 1.0
species: 769863
type: SpeciesReference

767488
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Formate
type: Species

814218
stoichiometry: 7.0
species: 769851
type: SpeciesReference

767112
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Eicosanoate (n-C20:0)
type: Species

854171
value: -1000.0
type: LocalParameter

815462
value: 0.0
type: LocalParameter

800972
value: 1000.0
type: LocalParameter

790336
kinetic law: 790373
product: 790360
reactant: 790348
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: CO2 transport (diffusion), mitochondrial
type: Reaction

846710
stoichiometry: 1.0
species: 766398
type: SpeciesReference

809790
value: 1000.0
type: LocalParameter

855310
stoichiometry: 1.0
species: 765816
type: SpeciesReference

850696
stoichiometry: 1.0
species: 769246
type: SpeciesReference

792531
value: -1000.0
type: LocalParameter

770044
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosadienoyl carnitine (C20:2Crn, n-6)
type: Species

768508
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octanoate
type: Species

783815
value: 0.0
type: LocalParameter

766192
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Acetaldehyde
type: Species

798372
value: 0.0
type: LocalParameter

786181
value: 1000.0
type: LocalParameter

830503
stoichiometry: 1.0
species: 766398
type: SpeciesReference

821718
stoichiometry: 1.0
species: 765852
type: SpeciesReference

810273
stoichiometry: 1.0
species: 766398
type: SpeciesReference

838963
stoichiometry: 1.0
species: 770550
type: SpeciesReference

805114
stoichiometry: 1.0
species: 768335
type: SpeciesReference

830719
value: 0.0
type: LocalParameter

828422
stoichiometry: 1.0
species: 767767
type: SpeciesReference

819975
stoichiometry: 1.0
species: 766616
type: SpeciesReference

829982
stoichiometry: 1.0
species: 770345
type: SpeciesReference

837708
kinetic law: 837744
product: 837732
reactant: 837720
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: Methylmalonate transport, mitochondrial
type: Reaction

811213
stoichiometry: 0.018
species: 768421
type: SpeciesReference

785262
stoichiometry: 1.0
species: 767633
type: SpeciesReference

852488
value: 0.0
type: LocalParameter

814085
stoichiometry: 7.0
species: 770622
type: SpeciesReference

768618
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoyl carnitine (C18:1Crn, n9)
type: Species

766944
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Dimethylallyl diphosphate
type: Species

842273
kinetic law: 842309
product: 842297
reactant: 842285
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecatrienoate (C18:3, n-3) transport
type: Reaction

826700
value: 0.0
type: LocalParameter

844546
type: Reaction
product: 844595
product: 844607
product: 844582
kinetic law: 844619
fast: false
reversible: false
reactant: 844558
name: 6-phosphofructo-2-kinase
notes: GENE_ASSOCIATION: (NM_002625.1 or NM_004567.2 or NM_004566.2 or NM_001018053.1 or NM_006212.2) GENE_LIST: NM_001018053.1 NM_002625.1 NM_004566.2 NM_004567.2 NM_006212.2 SUBSYSTEM: Fructose and Mannose Metabolism
reactant: 844570

828033
value: -1000.0
type: LocalParameter

778017
stoichiometry: 1.0
species: 765720
type: SpeciesReference

825849
stoichiometry: 1.0
species: 767621
type: SpeciesReference

767004
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosahexaenoyl carnitine (C22:6Crn, n-3)
type: Species

835652
value: 500.0
type: LocalParameter

827683
value: 0.0
type: LocalParameter

842686
value: 0.0
type: LocalParameter

851626
notes: SUBSYSTEM: Transport, Extracellular
product: 851662
fast: false
kinetic law: 851686
reactant: 851638
name: sulfate sodium symport, blood
type: Reaction
reactant: 851650
product: 851674
reversible: true

791719
value: 0.0
type: LocalParameter

839628
stoichiometry: 1.0
species: 768800
type: SpeciesReference

832213
stoichiometry: 1.0
species: 765950
type: SpeciesReference

841752
product: 841801
type: Reaction
reactant: 841764
fast: false
product: 841814
product: 841788
name: ornithine carbamoyltransferase, mitochondrial
reversible: true
kinetic law: 841826
notes: GENE_ASSOCIATION: NM_000531.3 GENE_LIST: NM_000531.3 SUBSYSTEM: Arginine and Proline Metabolism
reactant: 841776

827756
stoichiometry: 1.0
species: 767670
type: SpeciesReference

794440
stoichiometry: 1.0
species: 770405
type: SpeciesReference

788455
stoichiometry: 1.0
species: 769754
type: SpeciesReference

810790
value: -1000.0
type: LocalParameter

790889
reversible: true
reactant: 790913
name: carnitine docosenoyltransferase (C22:1Crn, n9), mitochondria
kinetic law: 790949
type: Reaction
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 790937
reactant: 790901
product: 790925
fast: false

832792
value: -1000.0
type: LocalParameter

794898
stoichiometry: 1.0
species: 768556
type: SpeciesReference

856311
value: 1000.0
type: LocalParameter

845463
value: 1000.0
type: LocalParameter

827030
stoichiometry: 1.0
species: 770261
type: SpeciesReference

833880
value: 1000.0
type: LocalParameter

816585
reactant: 816633
reactant: 816609
product: 816681
product: 816693
reactant: 816597
reactant: 816621
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_000018.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reversible: false
name: Beta oxidation of fatty acid
fast: false
product: 816657
type: Reaction
reactant: 816645
product: 816669
kinetic law: 816705

819071
stoichiometry: 7.0
species: 766616
type: SpeciesReference

823096
stoichiometry: 1.0
species: 766895
type: SpeciesReference

826920
stoichiometry: 1.0
species: 770285
type: SpeciesReference

800417
stoichiometry: 1.0
species: 765925
type: SpeciesReference

814642
stoichiometry: 1.0
species: 770792
type: SpeciesReference

841438
value: 0.0
type: LocalParameter

809247
reactant: 809272
product: 809320
reactant: 809259
type: Reaction
reactant: 809284
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004458.1 or NM_022977.1 or NM_203380.1 or NM_016234.3 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
fast: false
product: 809308
kinetic law: 809332
product: 809296
reversible: true
name: fatty-acid--CoA ligase (octadecadienoate, C18:3 n-3), hepatocyte

838555
value: 500.0
type: LocalParameter

844101
value: 0.0
type: LocalParameter

784917
type: Reaction
product: 784969
product: 784995
reactant: 784956
fast: false
reversible: false
name: argininosuccinate synthase
product: 785007
kinetic law: 785019
reactant: 784943
reactant: 784930
product: 784982
notes: GENE_ASSOCIATION: (NM_054012.2 or NM_000050.3) GENE_LIST: NM_000050.3 NM_054012.2 SUBSYSTEM: Urea Cycle

777438
stoichiometry: 1.0
species: 765648
type: SpeciesReference

799754
product: 799814
name: CTP synthase (NH3)
type: Reaction
product: 799826
reactant: 799790
reactant: 799778
reactant: 799766
product: 799802
product: 799838
reversible: false
kinetic law: 799850
notes: GENE_ASSOCIATION: NM_001905.1 GENE_LIST: NM_001905.1 SUBSYSTEM: Nucleotide Metabolism
fast: false

818346
stoichiometry: 1.0
species: 770165
type: SpeciesReference

813691
stoichiometry: 1.0
species: 770925
type: SpeciesReference

787150
stoichiometry: 1.0
species: 771264
type: SpeciesReference

770489
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Isocitrate
type: Species

776059
value: 500.0
type: LocalParameter

774329
kinetic law: 774365
product: 774353
reactant: 774341
fast: false
reversible: true
name: Eicosanoate (n-C20:0) exchange
type: Reaction

831479
stoichiometry: 1.0
species: 770333
type: SpeciesReference

786435
value: 0.0
type: LocalParameter

766386
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Aspartate
type: Species

767985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: heptadecanoyl CoA (C17:0CoA)
type: Species

772503
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: trp_L_b
type: Species

777968
value: 1000.0
type: LocalParameter

796374
stoichiometry: 1.0
species: 766616
type: SpeciesReference

808429
stoichiometry: 1.0
species: 766338
type: SpeciesReference

799680
stoichiometry: 1.0
species: 770333
type: SpeciesReference

795825
value: 0.0
type: LocalParameter

835266
kinetic law: 835326
name: malate transport, mitochondrial
reactant: 835278
notes: GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
reversible: true
reactant: 835290
fast: false
product: 835302
product: 835314
type: Reaction

776179
stoichiometry: 1.0
species: 765491
type: SpeciesReference

777546
stoichiometry: 1.0
species: 772370
type: SpeciesReference

812700
stoichiometry: 1.0
species: 770153
type: SpeciesReference

787371
value: 1000.0
type: LocalParameter

791453
value: 1000.0
type: LocalParameter

769379
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: UTP
type: Species

803856
value: 500.0
type: LocalParameter

770695
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: O2
type: Species

779812
stoichiometry: 1.0
species: 769851
type: SpeciesReference

849477
stoichiometry: 1.0
species: 768800
type: SpeciesReference

807478
value: 1000.0
type: LocalParameter

800564
stoichiometry: 1.0
species: 767779
type: SpeciesReference

854680
value: 0.0
type: LocalParameter

797950
stoichiometry: 1.0
species: 766628
type: SpeciesReference

805768
value: 1000.0
type: LocalParameter

822370
stoichiometry: 1.0
species: 765852
type: SpeciesReference

855651
kinetic law: 855687
product: 855675
reactant: 855663
notes: GENE_ASSOCIATION: (NM_003486.5 or NM_012244.2 or NM_018593.3 or NM_182728.1) GENE_LIST: NM_003486.5 NM_012244.2 NM_018593.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-tyrosine transport
type: Reaction

837164
value: 1000.0
type: LocalParameter

847121
stoichiometry: 1.0
species: 768800
type: SpeciesReference

804498
reactant: 804547
product: 804559
reactant: 804535
name: stearoyl-CoA desaturase (n-C22:0CoA -> C22:1CoA, n-9)
reactant: 804511
kinetic law: 804595
product: 804571
type: Reaction
notes: SUBSYSTEM: Fatty Acid Desaturation
fast: false
product: 804583
reversible: false
reactant: 804523

808573
stoichiometry: 1.0
species: 766338
type: SpeciesReference

819612
stoichiometry: 1.0
species: 766616
type: SpeciesReference

781490
value: 0.0
type: LocalParameter

847908
stoichiometry: 1.0
species: 770610
type: SpeciesReference

775405
stoichiometry: 1.0
species: 765394
type: SpeciesReference

768861
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Propionate
type: Species

821863
product: 821912
reactant: 821888
name: formimidoyltetrahydrofolate cyclodeaminase
notes: GENE_ASSOCIATION: (NM_006657.2 or NM_206965.1) GENE_LIST: NM_006657.2 NM_206965.1 SUBSYSTEM: Histidine Degradation
reversible: true
kinetic law: 821924
fast: false
product: 821900
type: Reaction
reactant: 821876

824036
value: -1000.0
type: LocalParameter

774874
value: 1000.0
type: LocalParameter

838891
value: 1000.0
type: LocalParameter

779533
value: 500.0
type: LocalParameter

853711
value: 0.0
type: LocalParameter

807199
value: 0.0
type: LocalParameter

778826
value: 0.0
type: LocalParameter

779268
value: 1000.0
type: LocalParameter

811648
stoichiometry: 1.0
species: 768359
type: SpeciesReference

807331
value: 1000.0
type: LocalParameter

788529
value: 0.0
type: LocalParameter

791936
value: 1000.0
type: LocalParameter

824132
value: -1000.0
type: LocalParameter

768933
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-Phospho-alpha-D-ribose 1-diphosphate
type: Species

765672
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: octadecadienoate (C18:2, n-6)
type: Species

845137
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type: LocalParameter

788674
stoichiometry: 0.001
species: 769778
type: SpeciesReference

822683
value: 0.0
type: LocalParameter

771420
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: D-Glucose 6-phosphate
type: Species

798155
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 798215
reversible: true
reactant: 798179
product: 798191
type: Reaction
name: carnitine palmitoyltransferase (C16:0Crn), mitochondrial
reactant: 798167
product: 798203
fast: false

783754
stoichiometry: 1.0
species: 766313
type: SpeciesReference

796798
value: 0.0
type: LocalParameter

849053
value: 0.0
type: LocalParameter

778174
value: 0.0
type: LocalParameter

779680
stoichiometry: 2.0
species: 766204
type: SpeciesReference

772250
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: leu_L_b
type: Species

789195
stoichiometry: 1.0
species: 766398
type: SpeciesReference

850128
value: 1000.0
type: LocalParameter

847001
stoichiometry: 2.0
species: 768800
type: SpeciesReference

776918
value: 0.0
type: LocalParameter

846191
value: 0.0
type: LocalParameter

832370
stoichiometry: 1.0
species: 769839
type: SpeciesReference

783962
value: 500.0
type: LocalParameter

827537
stoichiometry: 1.0
species: 765394
type: SpeciesReference

840752
value: 1000.0
type: LocalParameter

795079
value: 1000.0
type: LocalParameter

816718
value: 0.0
type: LocalParameter

812179
product: 812265
reversible: false
product: 812277
kinetic law: 812313
reactant: 812216
product: 812301
reactant: 812203
reactant: 812228
fast: false
product: 812252
type: Reaction
notes: SUBSYSTEM: Fatty Acid Synthesis
reactant: 812191
name: fatty-acyl-CoA elongation (C22:5CoA, n3)
reactant: 812240
product: 812289

805332
reactant: 805344
notes: GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Nucleotide Metabolism
reactant: 805356
name: dihydroorotase
type: Reaction
reversible: true
kinetic law: 805392
product: 805380
fast: false
product: 805368

780971
value: 0.0
type: LocalParameter

813540
stoichiometry: 6.0
species: 770333
type: SpeciesReference

843049
value: -1000.0
type: LocalParameter

793779
value: 0.0
type: LocalParameter

842808
value: -1000.0
type: LocalParameter

785044
value: 1000.0
type: LocalParameter

790661
stoichiometry: 1.0
species: 769851
type: SpeciesReference

845234
value: 0.0
type: LocalParameter

810646
value: -1000.0
type: LocalParameter

828751
value: 500.0
type: LocalParameter

853218
stoichiometry: 1.0
species: 770165
type: SpeciesReference

844739
stoichiometry: 1.0
species: 768310
type: SpeciesReference

819360
fast: false
kinetic law: 819480
product: 819420
product: 819456
reactant: 819396
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
reversible: false
product: 819432
reactant: 819384
reactant: 819372
product: 819468
type: Reaction
name: fatty acid synthase (C17:0), cytosol
reactant: 819408
product: 819444

813260
stoichiometry: 1.0
species: 769851
type: SpeciesReference

843205
value: 0.0
type: LocalParameter

853868
value: 500.0
type: LocalParameter

771576
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Squalene
type: Species

796045
value: -1000.0
type: LocalParameter

843350
value: 500.0
type: LocalParameter

820616
product: 820724
reversible: false
product: 820772
product: 820808
notes: SUBSYSTEM: Triglycerol Degradation
product: 820869
product: 820784
product: 820820
product: 820845
product: 820700
product: 820760
product: 820688
product: 820905
product: 820857
product: 820664
type: Reaction
product: 820917
name: Average fatty acid pseudoabstractase
product: 820676
product: 820881
kinetic law: 820929
product: 820893
product: 820833
product: 820736
product: 820796
reactant: 820628
fast: false
product: 820640
product: 820748
product: 820712
product: 820652

780259
value: 0.0
type: LocalParameter

810164
stoichiometry: 1.0
species: 766338
type: SpeciesReference

824240
stoichiometry: 1.0
species: 770261
type: SpeciesReference

774983
value: 0.0
type: LocalParameter

797840
stoichiometry: 1.0
species: 768726
type: SpeciesReference

808837
stoichiometry: 1.0
species: 766616
type: SpeciesReference

826140
value: -1000.0
type: LocalParameter

811756
value: 1000.0
type: LocalParameter

810947
value: 1000.0
type: LocalParameter

797550
product: 797586
kinetic law: 797610
name: carnitine pentadecanoyltransferase (C15:0Crn), mitochondria
reactant: 797562
type: Reaction
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
fast: false
reactant: 797574
product: 797598
reversible: true

825402
stoichiometry: 1.0
species: 767683
type: SpeciesReference

765563
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Methionine
type: Species

786701
value: 1000.0
type: LocalParameter

822792
value: 0.0
type: LocalParameter

793210
stoichiometry: 1.0
species: 770129
type: SpeciesReference

766604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: CO2
type: Species

790553
stoichiometry: 1.0
species: 766846
type: SpeciesReference

772672
stoichiometry: 0.004265
species: 766652
type: SpeciesReference

769137
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species

823398
value: 1000.0
type: LocalParameter

835905
value: 0.0
type: LocalParameter

807755
value: -1000.0
type: LocalParameter

817837
value: 1000.0
type: LocalParameter

805440
value: 0.0
type: LocalParameter

785685
value: -1000.0
type: LocalParameter

775756
value: 0.0
type: LocalParameter

840969
value: 0.0
type: LocalParameter

774038
kinetic law: 774075
product: 774063
reactant: 774050
fast: false
reversible: true
name: docosahexaenoate (C22:6, n-3) exchange
type: Reaction

849514
value: 0.0
type: LocalParameter

796689
value: 0.0
type: LocalParameter

783645
stoichiometry: 1.0
species: 768981
type: SpeciesReference

811104
stoichiometry: 0.007
species: 767177
type: SpeciesReference

825739
value: -1000.0
type: LocalParameter

787948
value: 1000.0
type: LocalParameter

831263
value: 0.0
type: LocalParameter

805962
stoichiometry: 1.0
species: 771660
type: SpeciesReference

831118
value: 0.0
type: LocalParameter

800648
stoichiometry: 1.0
species: 765201
type: SpeciesReference

838663
value: 0.0
type: LocalParameter

802336
value: 0.0
type: LocalParameter

796263
stoichiometry: 1.0
species: 770756
type: SpeciesReference

816826
stoichiometry: 1.0
species: 770877
type: SpeciesReference

777064
stoichiometry: 1.0
species: 772310
type: SpeciesReference

840511
value: 1000.0
type: LocalParameter

853094
stoichiometry: 1.0
species: 771119
type: SpeciesReference

781757
stoichiometry: 1.0
species: 766422
type: SpeciesReference

818237
value: 0.0
type: LocalParameter

816693
stoichiometry: 10.0
species: 770634
type: SpeciesReference

771876
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: asp_L_b
type: Species

784808
kinetic law: 784856
product: 784844
product: 784832
reactant: 784820
notes: GENE_ASSOCIATION: (NM_001024946.1 or NM_001024943.1 or NM_000048.3 or NM_001024944.1) GENE_LIST: NM_000048.3 NM_001024943.1 NM_001024944.1 NM_001024946.1 SUBSYSTEM: Urea Cycle
fast: false
reversible: true
name: argininosuccinate lyase
type: Reaction

801177
stoichiometry: 1.0
species: 767767
type: SpeciesReference

766034
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-4'-Phosphopantothenate
type: Species

809356
value: 1000.0
type: LocalParameter

802480
stoichiometry: 1.0
species: 768335
type: SpeciesReference

789085
stoichiometry: 1.0
species: 767767
type: SpeciesReference

831587
stoichiometry: 1.0
species: 770441
type: SpeciesReference

777100
value: 1000.0
type: LocalParameter

787090
value: 0.0
type: LocalParameter

839203
stoichiometry: 1.0
species: 771216
type: SpeciesReference

792981
stoichiometry: 1.0
species: 766628
type: SpeciesReference

815354
stoichiometry: 8.0
species: 770622
type: SpeciesReference

836605
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reactant: 836618
type: Reaction
product: 836654
reactant: 836630
product: 836666
reversible: false
kinetic law: 836678
fast: false
notes: GENE_ASSOCIATION: NM_000254.1 GENE_LIST: NM_000254.1 SUBSYSTEM: Methionine Metabolism
name: methionine synthase

774111
value: 0.0
type: LocalParameter

843909
stoichiometry: 1.0
species: 771070
type: SpeciesReference

788758
value: 1000.0
type: LocalParameter

786326
value: 0.0
type: LocalParameter

849367
stoichiometry: 1.0
species: 768957
type: SpeciesReference

814993
stoichiometry: 8.0
species: 770622
type: SpeciesReference

837588
value: 0.0
type: LocalParameter

802900
value: 0.0
type: LocalParameter

847278
value: 0.0
type: LocalParameter

837273
value: 0.0
type: LocalParameter

804389
stoichiometry: 1.0
species: 768359
type: SpeciesReference

782168
value: 0.0
type: LocalParameter

772804
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species: 767779
type: SpeciesReference

793622
value: -1000.0
type: LocalParameter

778440
value: -1000.0
type: LocalParameter

847484
stoichiometry: 1.0
species: 766604
type: SpeciesReference

799655
stoichiometry: 1.0
species: 769790
type: SpeciesReference

824324
product: 824385
reactant: 824348
notes: GENE_ASSOCIATION: (NM_006759.3 or NM_001001521.1) GENE_LIST: NM_001001521.1 NM_006759.3 SUBSYSTEM: Glycogen Metabolism
kinetic law: 824397
reactant: 824336
fast: false
name: UTP-glucose-1-phosphate uridylyltransferase
product: 824373
type: Reaction
reactant: 824360
reversible: true

851203
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type: LocalParameter

834698
stoichiometry: 2.0
species: 771456
type: SpeciesReference

851794
stoichiometry: 1.0
species: 768359
type: SpeciesReference

800201
value: 1000.0
type: LocalParameter

765828
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Tyrosine
type: Species

827997
stoichiometry: 1.0
species: 767658
type: SpeciesReference

836751
stoichiometry: 1.0
species: 765563
type: SpeciesReference

789716
value: 0.0
type: LocalParameter

835374
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type: LocalParameter

814848
stoichiometry: 7.0
species: 770165
type: SpeciesReference

816149
stoichiometry: 9.0
species: 770634
type: SpeciesReference

800852
value: 1000.0
type: LocalParameter

814242
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species: 770345
type: SpeciesReference

830925
stoichiometry: 1.0
species: 769851
type: SpeciesReference

808885
stoichiometry: 1.0
species: 768885
type: SpeciesReference

768421
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoate (C18:1, n-7)
type: Species

842103
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species: 765635
type: SpeciesReference

845027
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type: LocalParameter

813678
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species: 770622
type: SpeciesReference

765986
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-Phosphohydroxypyruvate
type: Species

843193
value: 0.0
type: LocalParameter

777980
value: 0.0
type: LocalParameter

839822
notes: GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Nucleotide Metabolism
type: Reaction
product: 839870
reactant: 839846
reversible: true
fast: false
reactant: 839834
kinetic law: 839882
name: nucleoside-diphosphate kinase (ATP:GDP)
product: 839858

809814
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type: LocalParameter

769391
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Valine
type: Species

841150
stoichiometry: 1.0
species: 768800
type: SpeciesReference

769452
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-2-Amino-3-oxobutanoate
type: Species

774341
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species: 765261
type: SpeciesReference

767343
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatetraenoyl-CoA (C20:4CoA, n-3)
type: Species

797514
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type: LocalParameter

780513
value: 0.0
type: LocalParameter

827342
value: 0.0
type: LocalParameter

782835
value: 500.0
type: LocalParameter

802504
stoichiometry: 1.0
species: 769137
type: SpeciesReference

833168
stoichiometry: 1.0
species: 768058
type: SpeciesReference

843945
stoichiometry: 1.0
species: 770719
type: SpeciesReference

789619
stoichiometry: 1.0
species: 766398
type: SpeciesReference

846819
value: 500.0
type: LocalParameter

818443
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type: LocalParameter

832962
stoichiometry: 1.0
species: 770501
type: SpeciesReference

820219
value: 1000.0
type: LocalParameter

838519
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type: LocalParameter

840219
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species: 769681
type: SpeciesReference

838458
stoichiometry: 1.0
species: 770622
type: SpeciesReference

851917
stoichiometry: 1.0
species: 770695
type: SpeciesReference

804158
value: 0.0
type: LocalParameter

818793
value: 0.0
type: LocalParameter

818383
stoichiometry: 1.0
species: 770634
type: SpeciesReference

826397
stoichiometry: 1.0
species: 770671
type: SpeciesReference

845427
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species: 765938
type: SpeciesReference

819324
value: 1000.0
type: LocalParameter

770321
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: GTP
type: Species

790985
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type: LocalParameter

819879
value: 0.0
type: LocalParameter

820060
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type: LocalParameter

813466
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species: 770153
type: SpeciesReference

782399
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type: LocalParameter

855553
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species: 769318
type: SpeciesReference

814605
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species: 770153
type: SpeciesReference

854243
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species: 769416
type: SpeciesReference

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type: LocalParameter

853639
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species: 769017
type: SpeciesReference

785238
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species: 766338
type: SpeciesReference

815197
stoichiometry: 9.0
species: 769657
type: SpeciesReference

806254
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type: LocalParameter

792677
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type: LocalParameter

785478
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kinetic law: 785552
product: 785527
reversible: true
product: 785539
notes: GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Nucleotide Metabolism
reactant: 785490
name: aspartate carbamoyltransferase (reversible)
fast: false
product: 785515
type: Reaction

822225
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species: 769428
type: SpeciesReference

811334
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species: 768885
type: SpeciesReference

852367
value: 500.0
type: LocalParameter

834856
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type: LocalParameter

845573
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type: LocalParameter

836872
stoichiometry: 1.0
species: 771660
type: SpeciesReference

835772
value: 0.0
type: LocalParameter

790757
value: 0.0
type: LocalParameter

794584
value: -1000.0
type: LocalParameter

805308
value: 0.0
type: LocalParameter

784083
value: 0.0
type: LocalParameter

810670
value: 0.0
type: LocalParameter

778415
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species: 772479
type: SpeciesReference

805234
stoichiometry: 1.0
species: 771216
type: SpeciesReference

767125
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Eicosanoyl-CoA (n-C20:0CoA)
type: Species

828178
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product: 828277
type: Reaction
reactant: 828227
fast: false
reactant: 828190
product: 828264
product: 828251
reactant: 828214
product: 828239
kinetic law: 828303
reactant: 828202
notes: GENE_ASSOCIATION: NM_003875.2 GENE_LIST: NM_003875.2 SUBSYSTEM: Nucleotide Metabolism
name: GMP synthase (glutamine-hydrolysing)
product: 828290

798047
stoichiometry: 1.0
species: 766628
type: SpeciesReference

783938
value: 1000.0
type: LocalParameter

842393
stoichiometry: 1.0
species: 768458
type: SpeciesReference

783415
value: 1000.0
type: LocalParameter

775962
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type: LocalParameter

813125
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species: 769657
type: SpeciesReference

827877
stoichiometry: 1.0
species: 765382
type: SpeciesReference

829282
value: 1000.0
type: LocalParameter

768726
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: propionyl-carnitine
type: Species

846505
stoichiometry: 1.0
species: 770985
type: SpeciesReference

796895
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type: LocalParameter

783560
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type: LocalParameter

788334
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type: LocalParameter

816295
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species: 769657
type: SpeciesReference

793090
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species: 767355
type: SpeciesReference

844402
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type: LocalParameter

848653
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species: 765913
type: SpeciesReference

798494
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type: LocalParameter

765406
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: H+
type: Species

806911
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product: 806937
reactant: 806924
notes: SUBSYSTEM: Transport, Extracellular
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reversible: true
name: Eicosatetraenoate (C20:4, n-6) transport
type: Reaction

832333
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species: 770489
type: SpeciesReference

817404
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species: 770333
type: SpeciesReference

833710
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type: LocalParameter

830623
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type: Reaction
product: 830671
name: homogentisate 1,2-dioxygenase
reactant: 830647
notes: GENE_ASSOCIATION: NM_000187.2 GENE_LIST: NM_000187.2 SUBSYSTEM: Tyrosine metabolism
reactant: 830635
reversible: false
fast: false
kinetic law: 830683

841898
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species: 768397
type: SpeciesReference

817283
value: 0.0
type: LocalParameter

829523
stoichiometry: 1.0
species: 767779
type: SpeciesReference

837901
value: 1000.0
type: LocalParameter

770189
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Ferricytochrome c
type: Species

766071
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-Formiminotetrahydrofolate
type: Species

792286
value: -1000.0
type: LocalParameter

789923
stoichiometry: 1.0
species: 769815
type: SpeciesReference

808285
stoichiometry: 1.0
species: 766338
type: SpeciesReference

779280
value: 0.0
type: LocalParameter

782449
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reactant: 782715
product: 782763
reactant: 782582
reactant: 782667
reactant: 782727
fast: false
kinetic law: 782787
reactant: 782679
reactant: 782703
reactant: 782534
reactant: 782655
reactant: 782606
reactant: 782546
product: 782775
reactant: 782739
reactant: 782618
reactant: 782642
reactant: 782461
reactant: 782474
reactant: 782486
reactant: 782510
reactant: 782594
notes: GENE_ASSOCIATION: (NM_006411.2 or NM_001037553.1 or NM_020132.4 or NM_001002257.1 or NM_020133.2 or NM_032741.3 or NM_001012727.1 or NM_006412.3 or NM_018361.3 or NM_153613.2 or NM_178819.2 or NM_182551.3) GENE_LIST: NM_001002257.1 NM_001012727.1 NM_001037553.1 NM_006411.2 NM_006412.3 NM_018361.3 NM_020132.4 NM_020133.2 NM_032741.3 NM_153613.2 NM_178819.2 NM_182551.3 SUBSYSTEM: Phospholipid Metabolism
name: 1-Acyl-glycerol-3-phosphate acyltransferase, adipocyte specific
type: Reaction
reversible: false
reactant: 782751
reactant: 782498
reactant: 782558
reactant: 782630
reactant: 782522
reactant: 782570

768837
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Palmitoylcarnitine (C16:0Crn)
type: Species

830068
value: 0.0
type: LocalParameter

771144
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species

850550
product: 850586
product: 850598
name: ribonucleoside-diphosphate reductase (CDP)
reactant: 850574
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotide Metabolism
reversible: false
fast: false
kinetic law: 850622
product: 850610
reactant: 850562
type: Reaction

808128
stoichiometry: 1.0
species: 767851
type: SpeciesReference

855627
value: 0.0
type: LocalParameter

775854
value: 0.0
type: LocalParameter

766932
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: (S)-Dihydroorotate
type: Species

840354
stoichiometry: 1.0
species: 767064
type: SpeciesReference

792128
stoichiometry: 1.0
species: 769851
type: SpeciesReference

834254
value: 0.0
type: LocalParameter

787960
value: 0.0
type: LocalParameter

783343
value: 500.0
type: LocalParameter

829970
stoichiometry: 1.0
species: 769839
type: SpeciesReference

823747
stoichiometry: 1.0
species: 771552
type: SpeciesReference

842285
stoichiometry: 1.0
species: 765660
type: SpeciesReference

778307
stoichiometry: 1.0
species: 765756
type: SpeciesReference

814097
stoichiometry: 8.0
species: 769657
type: SpeciesReference

785129
value: -1000.0
type: LocalParameter

838999
value: -1000.0
type: LocalParameter

806363
value: -1000.0
type: LocalParameter

838010
value: 0.0
type: LocalParameter

770213
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Formate
type: Species

788443
stoichiometry: 2.0
species: 769681
type: SpeciesReference

824882
stoichiometry: 0.03
species: 767864
type: SpeciesReference

829391
value: 0.0
type: LocalParameter

850974
value: 1000.0
type: LocalParameter

832225
stoichiometry: 1.0
species: 768359
type: SpeciesReference

794476
value: 1000.0
type: LocalParameter

827768
stoichiometry: 1.0
species: 766240
type: SpeciesReference

841740
value: 0.0
type: LocalParameter

825776
value: 0.0
type: LocalParameter

851638
stoichiometry: 1.0
species: 765575
type: SpeciesReference

849780
value: 0.0
type: LocalParameter

785588
value: 0.0
type: LocalParameter

817934
stoichiometry: 1.0
species: 770622
type: SpeciesReference

844558
stoichiometry: 1.0
species: 766398
type: SpeciesReference

828435
stoichiometry: 1.0
species: 769029
type: SpeciesReference

827090
value: 0.0
type: LocalParameter

825837
stoichiometry: 1.0
species: 766240
type: SpeciesReference

841599
value: -1000.0
type: LocalParameter

845791
stoichiometry: 1.0
species: 769318
type: SpeciesReference

784710
stoichiometry: 1.0
species: 770333
type: SpeciesReference

855346
value: 1000.0
type: LocalParameter

821705
product: 821754
fast: false
reactant: 821730
reactant: 821718
name: formyltetrahydrofolate dehydrogenase
reactant: 821742
reversible: false
type: Reaction
product: 821766
kinetic law: 821803
notes: GENE_ASSOCIATION: NM_012190.2 GENE_LIST: NM_012190.2 SUBSYSTEM: Folate Metabolism
product: 821791
product: 821778

813235
value: 500.0
type: LocalParameter

781178
stoichiometry: 1.0
species: 769657
type: SpeciesReference

833601
reactant: 833650
kinetic law: 833698
product: 833674
product: 833662
product: 833686
reactant: 833626
fast: false
type: Reaction
reversible: false
reactant: 833638
reactant: 833614
name: lathosterol oxidase (NAD), endoplasmic reticulum
notes: GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis

776362
kinetic law: 776398
product: 776386
reactant: 776374
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

815474
value: 500.0
type: LocalParameter

854183
value: 1000.0
type: LocalParameter

790324
value: 0.0
type: LocalParameter

845646
stoichiometry: 1.0
species: 770985
type: SpeciesReference

833300
stoichiometry: 1.0
species: 771756
type: SpeciesReference

850998
value: 0.0
type: LocalParameter

780959
value: 0.0
type: LocalParameter

842820
value: 1000.0
type: LocalParameter

782558
stoichiometry: 0.007
species: 767254
type: SpeciesReference

783827
value: 0.0
type: LocalParameter

786024
stoichiometry: 1.0
species: 768166
type: SpeciesReference

766180
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Acetoacetate
type: Species

847374
stoichiometry: 2.0
species: 770985
type: SpeciesReference

811418
stoichiometry: 5.0
species: 767767
type: SpeciesReference

798384
value: 0.0
type: LocalParameter

792567
value: 0.0
type: LocalParameter

830419
stoichiometry: 1.0
species: 765467
type: SpeciesReference

786884
stoichiometry: 1.0
species: 771240
type: SpeciesReference

810260
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_004458.1 or NM_203379.1 or NM_001009185.1 or NM_001995.2 or NM_004457.3 or NM_203380.1 or NM_016234.3 or NM_015256.2 or NM_022977.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Metabolism
product: 810309
product: 810321
reversible: true
reactant: 810273
kinetic law: 810345
reactant: 810285
product: 810333
name: fatty-acid--CoA ligase (docosanoate, C22:0)
type: Reaction
reactant: 810297
fast: false

782241
value: -1000.0
type: LocalParameter

839712
stoichiometry: 1.0
species: 766398
type: SpeciesReference

797768
value: 0.0
type: LocalParameter

811564
value: 1000.0
type: LocalParameter

782180
kinetic law: 782229
product: 782217
product: 782204
reactant: 782192
notes: GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: true
name: adenylosuccinate lyase
type: Reaction

808993
stoichiometry: 1.0
species: 768433
type: SpeciesReference

793911
product: 793959
fast: false
type: Reaction
kinetic law: 793972
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine eicosanoyltransferase (C20:0Crn), mitochondria
reactant: 793935
reactant: 793923
product: 793947
reversible: true

836642
stoichiometry: 1.0
species: 767767
type: SpeciesReference

791153
stoichiometry: 1.0
species: 766992
type: SpeciesReference

805537
value: -1000.0
type: LocalParameter

789824
stoichiometry: 1.0
species: 769790
type: SpeciesReference

773615
value: 1000.0
type: LocalParameter

772238
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: lac_L_b
type: Species

767452
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Fe2+
type: Species

833589
value: 0.0
type: LocalParameter

773760
stoichiometry: 1.0
species: 765189
type: SpeciesReference

787054
stoichiometry: 1.0
species: 771360
type: SpeciesReference

814956
stoichiometry: 8.0
species: 769851
type: SpeciesReference

854497
stoichiometry: 1.0
species: 768238
type: SpeciesReference

806497
value: 0.0
type: LocalParameter

848103
value: 0.0
type: LocalParameter

846747
stoichiometry: 1.0
species: 766240
type: SpeciesReference

803602
stoichiometry: 1.0
species: 768470
type: SpeciesReference

848763
type: Reaction
name: phosphoribosylformylglycinamidine synthase
fast: false
product: 848872
reactant: 848799
kinetic law: 848884
reversible: false
reactant: 848775
product: 848823
product: 848847
notes: GENE_ASSOCIATION: NM_012393.1 GENE_LIST: NM_012393.1 SUBSYSTEM: Nucleotide Metabolism
product: 848835
product: 848859
reactant: 848811
reactant: 848787

780803
stoichiometry: 1.0
species: 766556
type: SpeciesReference

788020
stoichiometry: 1.0
species: 770695
type: SpeciesReference

815908
stoichiometry: 9.0
species: 770345
type: SpeciesReference

833011
value: 0.0
type: LocalParameter

809512
value: 0.0
type: LocalParameter

765201
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Cysteine
type: Species

852743
stoichiometry: 1.0
species: 771612
type: SpeciesReference

807875
stoichiometry: 1.0
species: 768885
type: SpeciesReference

819216
stoichiometry: 2.0
species: 768335
type: SpeciesReference

817078
value: 0.0
type: LocalParameter

809922
value: -1000.0
type: LocalParameter

797405
value: 0.0
type: LocalParameter

816259
stoichiometry: 6.0
species: 770153
type: SpeciesReference

813357
stoichiometry: 1.0
species: 770333
type: SpeciesReference

820327
stoichiometry: 1.0
species: 766616
type: SpeciesReference

796227
stoichiometry: 1.0
species: 768482
type: SpeciesReference

781892
stoichiometry: 1.0
species: 766338
type: SpeciesReference

791045
stoichiometry: 1.0
species: 766628
type: SpeciesReference

819722
reactant: 819746
product: 819795
reactant: 819734
product: 819819
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
reactant: 819770
product: 819782
name: fatty acid synthase (n-C20:0)
kinetic law: 819843
reactant: 819758
product: 819807
reversible: false
type: Reaction
fast: false
product: 819831

838300
stoichiometry: 1.0
species: 769851
type: SpeciesReference

802239
value: 0.0
type: LocalParameter

816862
stoichiometry: 10.0
species: 770333
type: SpeciesReference

782727
stoichiometry: 0.064
species: 769101
type: SpeciesReference

799123
reactant: 799135
product: 799171
kinetic law: 799184
reactant: 799147
reversible: true
notes: SUBSYSTEM: Carnitine Shuttle
name: carnitine O-aceyltransferase, mitochondrial
product: 799159
fast: false
type: Reaction

801297
stoichiometry: 0.001
species: 767404
type: SpeciesReference

825994
stoichiometry: 1.0
species: 768286
type: SpeciesReference

812398
stoichiometry: 1.0
species: 771696
type: SpeciesReference

776906
value: 1000.0
type: LocalParameter

767791
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Hydrogen peroxide
type: Species

825619
stoichiometry: 1.0
species: 767609
type: SpeciesReference

778162
value: 1000.0
type: LocalParameter

793223
stoichiometry: 1.0
species: 769851
type: SpeciesReference

849041
value: 0.0
type: LocalParameter

820640
stoichiometry: 0.001
species: 766784
type: SpeciesReference

772792
stoichiometry: 2.6E-5
species: 767755
type: SpeciesReference

826287
value: 0.0
type: LocalParameter

790697
stoichiometry: 1.0
species: 769899
type: SpeciesReference

852258
stoichiometry: 1.0
species: 767779
type: SpeciesReference

822104
stoichiometry: 1.0
species: 771408
type: SpeciesReference

817717
stoichiometry: 1.0
species: 770345
type: SpeciesReference

783125
stoichiometry: 1.0
species: 766058
type: SpeciesReference

840788
kinetic law: 840825
product: 840812
reactant: 840800
notes: GENE_ASSOCIATION: (NM_016321.1 or NM_020407.1 or NM_000324.1) GENE_LIST: NM_000324.1 NM_016321.1 NM_020407.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ammonium transport via diffusion
type: Reaction

830287
value: 0.0
type: LocalParameter

813576
value: 0.0
type: LocalParameter

821141
stoichiometry: 1.0
species: 767392
type: SpeciesReference

808717
stoichiometry: 1.0
species: 766338
type: SpeciesReference

850828
stoichiometry: 1.0
species: 769005
type: SpeciesReference

807187
value: 1000.0
type: LocalParameter

811636
stoichiometry: 4.0
species: 768335
type: SpeciesReference

815041
stoichiometry: 8.0
species: 770333
type: SpeciesReference

822951
stoichiometry: 1.0
species: 767428
type: SpeciesReference

834542
stoichiometry: 1.0
species: 771324
type: SpeciesReference

856050
stoichiometry: 1.0
species: 769355
type: SpeciesReference

853747
stoichiometry: 1.0
species: 767767
type: SpeciesReference

779545
kinetic law: 779606
product: 779581
name: acetyl-CoA C-acetyltransferase, mitochondrial
type: Reaction
reactant: 779557
product: 779593
notes: GENE_ASSOCIATION: NM_000019.2 GENE_LIST: NM_000019.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
reactant: 779569
fast: false
reversible: true

811781
value: 500.0
type: LocalParameter

851953
value: 1000.0
type: LocalParameter

840086
stoichiometry: 1.0
species: 766458
type: SpeciesReference

810043
stoichiometry: 1.0
species: 768885
type: SpeciesReference

855408
stoichiometry: 1.0
species: 769186
type: SpeciesReference

787804
stoichiometry: 1.0
species: 771588
type: SpeciesReference

823182
value: 0.0
type: LocalParameter

776290
stoichiometry: 1.0
species: 772214
type: SpeciesReference

802660
stoichiometry: 1.0
species: 768825
type: SpeciesReference

773471
stoichiometry: 1.0
species: 765153
type: SpeciesReference

846964
stoichiometry: 1.0
species: 767779
type: SpeciesReference

848980
stoichiometry: 1.0
species: 768286
type: SpeciesReference

848532
stoichiometry: 1.0
species: 768800
type: SpeciesReference

798167
stoichiometry: 1.0
species: 769851
type: SpeciesReference

810802
value: 1000.0
type: LocalParameter

771456
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: H2O
type: Species

845864
kinetic law: 845900
product: 845888
reactant: 845876
notes: GENE_ASSOCIATION: (NM_003486.5 or NM_018593.3 or NM_003627.4 or NM_012244.2 or NM_182728.1) GENE_LIST: NM_003486.5 NM_003627.4 NM_012244.2 NM_018593.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-phenylalanine transport via diffusion (extracellular to cytosol)
type: Reaction

768945
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Phosphatidylserine, human adipocyte
type: Species

845125
value: 1000.0
type: LocalParameter

770889
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: ocosatetraenoyl carnitine (C22:4Crn, n-6)
type: Species

780379
value: 0.0
type: LocalParameter

822671
value: 1000.0
type: LocalParameter

775634
value: -1000.0
type: LocalParameter

788662
product: 788710
product: 788698
notes: GENE_ASSOCIATION: NM_024419.3 GENE_LIST: NM_024419.3 SUBSYSTEM: Phospholipid Metabolism
reactant: 788686
name: CDP-diacylglycerol--serine O-phosphatidyltransferae, mitochondrial, human adipoctye
reversible: true
type: Reaction
reactant: 788674
kinetic law: 788734
fast: false
product: 788722

793331
stoichiometry: 1.0
species: 769863
type: SpeciesReference

791900
stoichiometry: 1.0
species: 769911
type: SpeciesReference

777245
stoichiometry: 1.0
species: 765623
type: SpeciesReference

779800
stoichiometry: 1.0
species: 769609
type: SpeciesReference

818224
value: 1000.0
type: LocalParameter

803820
value: 0.0
type: LocalParameter

822804
value: 0.0
type: LocalParameter

812712
stoichiometry: 1.0
species: 770345
type: SpeciesReference

767670
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Glycerol
type: Species

777534
stoichiometry: 1.0
species: 765660
type: SpeciesReference

777318
value: 500.0
type: LocalParameter

776143
value: 0.0
type: LocalParameter

787383
value: 0.0
type: LocalParameter

796386
stoichiometry: 1.0
species: 768544
type: SpeciesReference

772515
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ttdca_b
type: Species

774232
kinetic law: 774268
product: 774256
reactant: 774244
fast: false
reversible: true
name: dodecanoate (C12:0) exchange
type: Reaction

835230
value: 1000.0
type: LocalParameter

801805
stoichiometry: 1.0
species: 767767
type: SpeciesReference

849900
reactant: 849924
fast: false
notes: GENE_ASSOCIATION: (NM_001042530.1 or NM_001042532.1 or NM_001042531.1 or NM_025233.4 or NM_001042529.1) GENE_LIST: NM_001042529.1 NM_001042530.1 NM_001042531.1 NM_001042532.1 NM_025233.4 SUBSYSTEM: CoA Biosynthesis
reactant: 849912
type: Reaction
reversible: true
reactant: 849936
kinetic law: 849972
name: pantetheine-phosphate adenylyltransferase
product: 849948
product: 849960

831443
stoichiometry: 1.0
species: 769657
type: SpeciesReference

797987
value: -1000.0
type: LocalParameter

839930
value: 0.0
type: LocalParameter

837091
kinetic law: 837140
product: 837128
reactant: 837116
reactant: 837104
notes: GENE_ASSOCIATION: NM_001698.1 GENE_LIST: NM_001698.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: methylglutaconyl-CoA hydratase
type: Reaction

819600
stoichiometry: 1.0
species: 766604
type: SpeciesReference

847157
value: 0.0
type: LocalParameter

837152
value: -1000.0
type: LocalParameter

836424
value: 0.0
type: LocalParameter

778609
stoichiometry: 1.0
species: 772503
type: SpeciesReference

849630
value: 1000.0
type: LocalParameter

828595
value: 1000.0
type: LocalParameter

805756
value: -1000.0
type: LocalParameter

822382
stoichiometry: 1.0
species: 766240
type: SpeciesReference

834969
value: 0.0
type: LocalParameter

793501
value: -1000.0
type: LocalParameter

840655
value: 0.0
type: LocalParameter

819083
stoichiometry: 5.0
species: 767779
type: SpeciesReference

851359
reactant: 851396
reactant: 851371
name: serine C-palmitoyltransferase
product: 851409
product: 851421
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: ((NM_004863.2 and NM_006415.2) or (NM_004863.2 and NM_178324.1)) GENE_LIST: NM_004863.2 NM_006415.2 NM_178324.1 SUBSYSTEM: Sphingolipid Metabolism
reactant: 851384
product: 851433
kinetic law: 851445

816573
value: 500.0
type: LocalParameter

827066
value: -1000.0
type: LocalParameter

771996
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ecsea9_b
type: Species

805684
value: 0.0
type: LocalParameter

782024
value: -1000.0
type: LocalParameter

856167
stoichiometry: 1.0
species: 769573
type: SpeciesReference

844113
value: 1000.0
type: LocalParameter

842673
value: 1000.0
type: LocalParameter

799766
stoichiometry: 1.0
species: 766398
type: SpeciesReference

802456
reactant: 802468
product: 802528
name: Myristicoyl-CoA desaturase (n-C14:0CoA -> C14:1CoA, n-5)
reactant: 802504
type: Reaction
kinetic law: 802552
product: 802540
product: 802516
notes: GENE_ASSOCIATION: (NM_001037582.1 or NM_024906.1 or NM_005063.4) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Desaturation
reactant: 802480
reversible: false
fast: false
reactant: 802492

809235
value: 0.0
type: LocalParameter

816427
stoichiometry: 1.0
species: 770129
type: SpeciesReference

769693
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 2-Oxoglutarate
type: Species

782896
stoichiometry: 1.0
species: 767815
type: SpeciesReference

823084
stoichiometry: 1.0
species: 768298
type: SpeciesReference

796446
value: 0.0
type: LocalParameter

809380
value: 0.0
type: LocalParameter

806629
stoichiometry: 1.0
species: 767177
type: SpeciesReference

829826
value: 0.0
type: LocalParameter

786314
value: 0.0
type: LocalParameter

774595
value: 0.0
type: LocalParameter

801914
value: 0.0
type: LocalParameter

835121
value: 0.0
type: LocalParameter

774123
value: 500.0
type: LocalParameter

839215
stoichiometry: 4.0
species: 767767
type: SpeciesReference

792993
stoichiometry: 1.0
species: 770044
type: SpeciesReference

799874
value: 1000.0
type: LocalParameter

767561
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Glyceraldehyde 3-phosphate
type: Species

787492
stoichiometry: 3.0
species: 771516
type: SpeciesReference

836532
stoichiometry: 1.0
species: 768335
type: SpeciesReference

769234
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Oxidized thioredoxin
type: Species

848872
stoichiometry: 1.0
species: 768800
type: SpeciesReference

843605
value: 0.0
type: LocalParameter

794716
value: 1000.0
type: LocalParameter

821423
value: -1000.0
type: LocalParameter

787163
stoichiometry: 1.0
species: 771516
type: SpeciesReference

766784
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosenoate (C22:1, n-9)
type: Species

774449
stoichiometry: 1.0
species: 771984
type: SpeciesReference

808549
stoichiometry: 1.0
species: 766616
type: SpeciesReference

802912
value: 500.0
type: LocalParameter

804377
stoichiometry: 1.0
species: 768310
type: SpeciesReference

791840
value: 0.0
type: LocalParameter

849355
stoichiometry: 1.0
species: 766300
type: SpeciesReference

821570
product: 821632
name: S-Formylglutathione hydrolase
reactant: 821595
notes: GENE_ASSOCIATION: NM_001984.1 GENE_LIST: NM_001984.1 SUBSYSTEM: Tyrosine metabolism
fast: false
reactant: 821583
kinetic law: 821644
product: 821620
product: 821608
type: Reaction
reversible: false

789072
stoichiometry: 1.0
species: 766640
type: SpeciesReference

855771
stoichiometry: 1.0
species: 769355
type: SpeciesReference

854025
stoichiometry: 1.0
species: 769210
type: SpeciesReference

838675
value: 0.0
type: LocalParameter

802348
value: 0.0
type: LocalParameter

848250
value: -1000.0
type: LocalParameter

845209
stoichiometry: 1.0
species: 767767
type: SpeciesReference

819192
stoichiometry: 3.0
species: 767767
type: SpeciesReference

800636
product: 800672
name: L-cysteine reversible transport via sodium symport, reversible, blood
type: Reaction
reactant: 800648
fast: false
reactant: 800660
notes: GENE_ASSOCIATION: (NM_005628.1 or NM_003038.2 or NM_018018.2 or NM_007231.1) GENE_LIST: NM_003038.2 NM_005628.1 NM_007231.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
kinetic law: 800696
product: 800684
reversible: true

832672
value: 0.0
type: LocalParameter

776083
stoichiometry: 1.0
species: 765479
type: SpeciesReference

772947
stoichiometry: 2.0E-6
species: 768945
type: SpeciesReference

809669
value: 0.0
type: LocalParameter

801189
stoichiometry: 0.001
species: 768714
type: SpeciesReference

781322
stoichiometry: 1.0
species: 770333
type: SpeciesReference

842564
value: 0.0
type: LocalParameter

771888
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: chol_b
type: Species

820917
stoichiometry: 0.002
species: 769306
type: SpeciesReference

853976
reactant: 853988
fast: false
product: 854013
reversible: true
reactant: 854001
notes: GENE_ASSOCIATION: (NM_007231.1 or NM_030674.2 or NM_001077484.1 or NM_018976.3 or NM_018018.2) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
product: 854025
type: Reaction
name: L-threonine via sodium symport, blood
kinetic law: 854037

850248
value: 1000.0
type: LocalParameter

787271
product: 787334
notes: GENE_ASSOCIATION: (NM_016371.2 or NM_016142.1 or NM_002153.1 or NM_003725.2) GENE_LIST: NM_002153.1 NM_003725.2 NM_016142.1 NM_016371.2 SUBSYSTEM: Cholesterol Biosynthesis
name: C-3 sterol keto reductase (zymosterol), endoplasmic reticulum
reactant: 787310
reversible: false
fast: false
type: Reaction
product: 787322
kinetic law: 787347
reactant: 787284
reactant: 787297

794608
value: 0.0
type: LocalParameter

794128
value: 0.0
type: LocalParameter

828931
stoichiometry: 1.0
species: 767488
type: SpeciesReference

827659
stoichiometry: 1.0
species: 769330
type: SpeciesReference

783633
stoichiometry: 1.0
species: 767633
type: SpeciesReference

796677
value: 0.0
type: LocalParameter

769101
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Stearyl-CoA (n-C18:0CoA)
type: Species

778053
value: 0.0
type: LocalParameter

775744
value: 1000.0
type: LocalParameter

807767
value: 1000.0
type: LocalParameter

774026
value: 500.0
type: LocalParameter

807076
value: -1000.0
type: LocalParameter

805452
name: dihydropteridine reductase
kinetic law: 805525
type: Reaction
fast: false
product: 805513
reactant: 805476
reactant: 805464
reactant: 805489
product: 805501
notes: GENE_ASSOCIATION: NM_000320.1 GENE_LIST: NM_000320.1 SUBSYSTEM: Tyrosine metabolism
reversible: true

785697
value: 1000.0
type: LocalParameter

817825
value: 0.0
type: LocalParameter

835917
value: 0.0
type: LocalParameter

772684
stoichiometry: 2.44E-4
species: 766688
type: SpeciesReference

829670
value: 1000.0
type: LocalParameter

833480
type: Reaction
product: 833516
reversible: true
product: 833529
name: L-lactate reversible transport via proton symport
fast: false
kinetic law: 833541
reactant: 833504
notes: GENE_ASSOCIATION: (NM_003051.3 or NM_001042423.1 or NM_001042422.1 or NM_004731.3 or NM_004207.1 or NM_013356.1 or NM_004696.1) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004696.1 NM_004731.3 NM_013356.1 SUBSYSTEM: Transport, Extracellular
reactant: 833492

790541
stoichiometry: 1.0
species: 766628
type: SpeciesReference

852148
stoichiometry: 2.0
species: 768335
type: SpeciesReference

831106
value: 0.0
type: LocalParameter

828727
value: 1000.0
type: LocalParameter

793659
value: 0.0
type: LocalParameter

772394
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ocsttea6_b
type: Species

840897
stoichiometry: 1.0
species: 768347
type: SpeciesReference

837394
value: 0.0
type: LocalParameter

773313
value: 0.0
type: LocalParameter

831299
stoichiometry: 1.0
species: 766204
type: SpeciesReference

779655
value: 0.0
type: LocalParameter

768642
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Orotate
type: Species

770081
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosenoyl carnitine (C20:1Crn, n-11)
type: Species

805998
stoichiometry: 1.0
species: 771756
type: SpeciesReference

822526
value: -1000.0
type: LocalParameter

843775
stoichiometry: 1.0
species: 766338
type: SpeciesReference

852597
stoichiometry: 2.0
species: 771564
type: SpeciesReference

773072
stoichiometry: 1.06413
species: 767767
type: SpeciesReference

811116
stoichiometry: 0.003
species: 767189
type: SpeciesReference

845355
value: 0.0
type: LocalParameter

813014
value: 1000.0
type: LocalParameter

842977
reactant: 842989
type: Reaction
product: 843025
name: ornithine transport, mitochondrial
reactant: 843001
notes: GENE_ASSOCIATION: (NM_031947.2 or NM_014252.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
kinetic law: 843037
product: 843013
fast: false
reversible: true

824252
stoichiometry: 1.0
species: 770333
type: SpeciesReference

808825
stoichiometry: 1.0
species: 766398
type: SpeciesReference

784943
stoichiometry: 1.0
species: 766398
type: SpeciesReference

774995
value: 0.0
type: LocalParameter

844330
stoichiometry: 1.0
species: 769839
type: SpeciesReference

853856
value: 0.0
type: LocalParameter

812071
stoichiometry: 1.0
species: 766616
type: SpeciesReference

771564
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Diphosphate
type: Species

844727
stoichiometry: 1.0
species: 767767
type: SpeciesReference

828871
value: 0.0
type: LocalParameter

795969
name: carnitine octadecadienoyltransferase (C18:2Crn, n6)
reactant: 795994
kinetic law: 796033
notes: GENE_ASSOCIATION: (NM_001031847.1 or NM_001876.2 or NM_152359.1 or NM_152247.1 or NM_004377.2 or NM_152245.1 or NM_152246.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 796007
type: Reaction
product: 796020
fast: false
reactant: 795981
reversible: true

768082
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Isopentenyl diphosphate
type: Species

830841
value: 1000.0
type: LocalParameter

765551
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Lysine
type: Species

786713
value: 0.0
type: LocalParameter

823290
value: 0.0
type: LocalParameter

838771
value: 1000.0
type: LocalParameter

788553
kinetic law: 788601
product: 788589
reactant: 788577
reactant: 788565
notes: GENE_ASSOCIATION: NM_001801.2 GENE_LIST: NM_001801.2 SUBSYSTEM: Cysteine Metabolism
fast: false
reversible: false
name: cysteine dioxygenase
type: Reaction

810911
stoichiometry: 1.0
species: 768885
type: SpeciesReference

826176
value: 0.0
type: LocalParameter

798276
product: 798312
product: 798324
reactant: 798288
kinetic law: 798336
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
type: Reaction
fast: false
reactant: 798300
name: Palmitoylcarnitine shuttle (C16:0Crn), mitochondrial

800786
stoichiometry: 1.0
species: 766592
type: SpeciesReference

803710
notes: GENE_ASSOCIATION: (NM_004265.2 or NM_021727.3) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Synthesis
kinetic law: 803808
reactant: 803734
type: Reaction
reversible: false
reactant: 803759
product: 803772
product: 803784
reactant: 803722
fast: false
product: 803796
name: stearoyl-CoA desaturase (C18:3CoA, n3 -> C18:4CoA, n3)
reactant: 803747

843933
stoichiometry: 1.0
species: 770333
type: SpeciesReference

846807
value: 0.0
type: LocalParameter

818431
value: 0.0
type: LocalParameter

788238
stoichiometry: 1.0
species: 767779
type: SpeciesReference

797526
value: 0.0
type: LocalParameter

818370
stoichiometry: 1.0
species: 770453
type: SpeciesReference

777896
value: -1.103243E-4
type: LocalParameter

826908
stoichiometry: 1.0
species: 767645
type: SpeciesReference

840207
stoichiometry: 1.0
species: 769766
type: SpeciesReference

771708
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Glycine
type: Species

832950
stoichiometry: 1.0
species: 768046
type: SpeciesReference

814618
stoichiometry: 8.0
species: 770345
type: SpeciesReference

820760
stoichiometry: 0.243
species: 767827
type: SpeciesReference

819336
value: 0.0
type: LocalParameter

790973
value: 1000.0
type: LocalParameter

837078
value: 0.0
type: LocalParameter

826385
stoichiometry: 1.0
species: 770634
type: SpeciesReference

804146
value: 1000.0
type: LocalParameter

818781
value: 1000.0
type: LocalParameter

782823
value: 0.0
type: LocalParameter

854255
stoichiometry: 1.0
species: 767392
type: SpeciesReference

841451
kinetic law: 841487
product: 841475
reactant: 841463
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: O2 endoplamic reticulum transport
type: Reaction

813454
stoichiometry: 6.0
species: 769851
type: SpeciesReference

820206
value: 0.0
type: LocalParameter

851215
value: 1000.0
type: LocalParameter

834686
stoichiometry: 1.0
species: 771372
type: SpeciesReference

792299
value: 1000.0
type: LocalParameter

804292
value: 0.0
type: LocalParameter

799667
stoichiometry: 1.0
species: 769851
type: SpeciesReference

824336
stoichiometry: 1.0
species: 767549
type: SpeciesReference

803506
value: 0.0
type: LocalParameter

792812
value: 0.0
type: LocalParameter

784930
stoichiometry: 1.0
species: 766386
type: SpeciesReference

839918
value: 0.0
type: LocalParameter

855566
stoichiometry: 1.0
species: 765950
type: SpeciesReference

835362
value: 0.0
type: LocalParameter

824481
stoichiometry: 1.0
species: 768298
type: SpeciesReference

813665
stoichiometry: 1.0
species: 770345
type: SpeciesReference

800213
value: 0.0
type: LocalParameter

806834
stoichiometry: 1.0
species: 767189
type: SpeciesReference

827985
kinetic law: 828021
product: 828009
reactant: 827997
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: glycine passive transport to mitochondria
type: Reaction

854594
kinetic law: 854630
product: 854618
reactant: 854606
notes: GENE_ASSOCIATION: NM_000365.4 GENE_LIST: NM_000365.4 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: triose-phosphate isomerase
type: Reaction

808873
stoichiometry: 1.0
species: 768569
type: SpeciesReference

814230
stoichiometry: 6.0
species: 770153
type: SpeciesReference

827355
product: 827440
name: glycine cleavage system, mitochondrial
reactant: 827367
fast: false
notes: GENE_ASSOCIATION: (NM_000481.2 and NM_000108.3 and NM_004483.3 and NM_000170.1) GENE_LIST: NM_000108.3 NM_000170.1 NM_000481.2 NM_004483.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
reactant: 827391
type: Reaction
reversible: false
kinetic law: 827452
reactant: 827379
product: 827403
product: 827415
product: 827427

830938
stoichiometry: 1.0
species: 770333
type: SpeciesReference

780525
notes: GENE_ASSOCIATION: NM_130767.2 GENE_LIST: NM_130767.2 SUBSYSTEM: Pyruvate Metabolism
product: 780586
fast: false
product: 780574
name: acetyl-CoA hydrolase
product: 780561
reactant: 780537
kinetic law: 780598
reversible: false
type: Reaction
reactant: 780549

809826
product: 809874
kinetic law: 809910
reactant: 809838
product: 809886
fast: false
reactant: 809850
name: fatty-acid--CoA ligase (eicosadienoate, C20:2 n-6), hepatocyte
product: 809898
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203372.1 or NM_203379.1 or NM_004458.1 or NM_203380.1 or NM_004457.3 or NM_022977.1 or NM_016234.3) GENE_LIST: NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reactant: 809862
type: Reaction
reversible: true

769464
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 2-Methyl-3-acetoacetyl-CoA
type: Species

801708
stoichiometry: 1.0
species: 771046
type: SpeciesReference

774353
stoichiometry: 1.0
species: 771972
type: SpeciesReference

833468
value: 0.0
type: LocalParameter

767355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatetraenoyl-CoA (C20:4CoA, n-6)
type: Species

845015
value: 0.0
type: LocalParameter

765998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-Sulfino-L-alanine
type: Species

843181
value: 1000.0
type: LocalParameter

777992
value: 0.0
type: LocalParameter

824108
stoichiometry: 1.0
species: 771420
type: SpeciesReference

844414
kinetic law: 844486
fast: false
product: 844474
name: phosphofructokinase
product: 844450
type: Reaction
notes: GENE_ASSOCIATION: (NM_002626.4 or NM_001002021.1 or NM_000289.3 or NM_002627.3 or (NM_000289.3 and NM_001002021.1) or (NM_000289.3 and NM_002626.4) or (NM_001002021.1 and NM_002627.3) or (NM_002626.4 and NM_002627.3)) GENE_LIST: NM_000289.3 NM_001002021.1 NM_002626.4 NM_002627.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
reversible: false
reactant: 844438
reactant: 844426
product: 844462

829536
stoichiometry: 1.0
species: 770345
type: SpeciesReference

830635
stoichiometry: 1.0
species: 767912
type: SpeciesReference

841886
kinetic law: 841922
product: 841910
reactant: 841898
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecanoate (n-C18:0) transport in via uniport
type: Reaction

833722
value: 1000.0
type: LocalParameter

848665
stoichiometry: 1.0
species: 766240
type: SpeciesReference

770177
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Fe2+
type: Species

847471
stoichiometry: 1.0
species: 767767
type: SpeciesReference

817295
value: 500.0
type: LocalParameter

768849
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: (R)-Pantothenate
type: Species

771132
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Succinyl-CoA
type: Species

850562
stoichiometry: 1.0
species: 766458
type: SpeciesReference

807319
value: -1000.0
type: LocalParameter

808297
stoichiometry: 1.0
species: 767985
type: SpeciesReference

779292
value: 0.0
type: LocalParameter

822237
stoichiometry: 1.0
species: 769681
type: SpeciesReference

835784
value: 0.0
type: LocalParameter

845585
value: 0.0
type: LocalParameter

836884
stoichiometry: 1.0
species: 771768
type: SpeciesReference

852355
value: 0.0
type: LocalParameter

767138
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosanoylcarnitine, C20:0crn
type: Species

853627
stoichiometry: 1.0
species: 767561
type: SpeciesReference

806266
value: 1000.0
type: LocalParameter

792665
value: 1000.0
type: LocalParameter

815185
stoichiometry: 1.0
species: 770744
type: SpeciesReference

793791
notes: GENE_ASSOCIATION: (NM_152359.1 or NM_004377.2 or NM_152246.1 or NM_001031847.1 or NM_152245.1 or NM_001876.2 or NM_152247.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 793827
reactant: 793815
reactant: 793803
reversible: true
fast: false
type: Reaction
kinetic law: 793851
product: 793839
name: carnitine eicosanoyltransferase (C20:0Crn)

790745
value: 0.0
type: LocalParameter

784071
value: 1000.0
type: LocalParameter

834844
value: 1000.0
type: LocalParameter

823627
stoichiometry: 1.0
species: 770985
type: SpeciesReference

798035
fast: false
product: 798083
kinetic law: 798095
reversible: true
name: carnitine O-palmitoyltransferase (C16:0Crn)
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_001031847.1 or NM_152359.1 or NM_152246.1 or NM_004377.2 or NM_001876.2 or NM_152247.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 798071
reactant: 798059
reactant: 798047
type: Reaction

805246
stoichiometry: 1.0
species: 768642
type: SpeciesReference

828166
value: 0.0
type: LocalParameter

829294
value: 0.0
type: LocalParameter

832346
stoichiometry: 1.0
species: 770622
type: SpeciesReference

775950
value: 0.0
type: LocalParameter

813137
stoichiometry: 1.0
species: 770019
type: SpeciesReference

783403
value: -1000.0
type: LocalParameter

827889
stoichiometry: 1.0
species: 765575
type: SpeciesReference

855334
value: -1000.0
type: LocalParameter

777450
stoichiometry: 1.0
species: 772358
type: SpeciesReference

768739
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: pentadecanoyl-CoA (C15:0CoA)
type: Species

853302
value: 0.0
type: LocalParameter

846734
stoichiometry: 1.0
species: 766034
type: SpeciesReference

776374
stoichiometry: 1.0
species: 765515
type: SpeciesReference

790312
value: 0.0
type: LocalParameter

815486
product: 815570
type: Reaction
reactant: 815510
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_001037811.2) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_001037811.2) or (NM_001033859.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
kinetic law: 815618
fast: false
product: 815582
reactant: 815522
name: Beta oxidation of long chain fatty acid
reactant: 815534
product: 815558
reactant: 815546
product: 815606
reactant: 815498
product: 815594
reversible: false

800996
value: 0.0
type: LocalParameter

854195
value: 0.0
type: LocalParameter

842832
value: 0.0
type: LocalParameter

813248
reactant: 813260
reversible: false
reactant: 813272
reactant: 813308
type: Reaction
fast: false
kinetic law: 813381
product: 813369
product: 813332
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092... GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092... NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
name: Beta oxidation of long chain fatty acid
product: 813357
product: 813344
product: 813320
reactant: 813284
reactant: 813296

774705
value: 500.0
type: LocalParameter

817609
stoichiometry: 1.0
species: 771034
type: SpeciesReference

833614
stoichiometry: 1.0
species: 771444
type: SpeciesReference

780947
value: 1000.0
type: LocalParameter

850986
value: 0.0
type: LocalParameter

792555
value: 0.0
type: LocalParameter

797200
stoichiometry: 1.0
species: 769851
type: SpeciesReference

783839
reversible: false
product: 783876
product: 783888
kinetic law: 783913
fast: false
name: alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
product: 783901
notes: GENE_ASSOCIATION: NM_000672.2 GENE_LIST: NM_000672.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
type: Reaction
reactant: 783851
reactant: 783864

847362
stoichiometry: 1.0
species: 770333
type: SpeciesReference

811406
product: 811502
reactant: 811430
fast: false
product: 811478
type: Reaction
reactant: 811442
reactant: 811454
product: 811490
product: 811514
product: 811527
notes: GENE_ASSOCIATION: NM_021814.3 GENE_LIST: NM_021814.3 SUBSYSTEM: Fatty acid elongation
kinetic law: 811540
reactant: 811418
name: fatty-acyl-CoA elongation (n-C20:2CoA, n6)
reversible: false
reactant: 811466

786012
stoichiometry: 1.0
species: 767633
type: SpeciesReference

798396
reversible: true
fast: false
reactant: 798420
name: carnitine tetradecenoyltransferase (C14:1Crn, n5)
product: 798445
reactant: 798408
notes: GENE_ASSOCIATION: (NM_152359.1 or NM_004377.2 or NM_001031847.1 or NM_152247.1 or NM_152245.1 or NM_152246.1 or NM_001876.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
type: Reaction
product: 798432
kinetic law: 798457

792116
stoichiometry: 1.0
species: 770057
type: SpeciesReference

787972
value: 500.0
type: LocalParameter

783331
value: 0.0
type: LocalParameter

790529
product: 790577
reactant: 790553
name: carnitine dodecanoyltransferase (C12:0Crn)
fast: false
product: 790565
notes: GENE_ASSOCIATION: (NM_152359.1 or NM_152245.1 or NM_001031847.1 or NM_152246.1 or NM_152247.1 or NM_004377.2 or NM_001876.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
type: Reaction
reversible: true
kinetic law: 790589
reactant: 790541

788430
stoichiometry: 1.0
species: 770671
type: SpeciesReference

855639
value: 0.0
type: LocalParameter

766920
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 7,8-Dihydrofolate
type: Species

819951
stoichiometry: 2.0
species: 768335
type: SpeciesReference

838022
value: 0.0
type: LocalParameter

823735
stoichiometry: 1.0
species: 771432
type: SpeciesReference

806375
value: 1000.0
type: LocalParameter

770201
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Ferrocytochrome c
type: Species

842297
stoichiometry: 1.0
species: 768446
type: SpeciesReference

799413
stoichiometry: 1.0
species: 766616
type: SpeciesReference

834266
kinetic law: 834302
product: 834290
reactant: 834278
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Leucine transport, Homo Sapiens mitochondria
type: Reaction

770069
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosenoyl-CoA (C20:1CoA, n-9)
type: Species

826493
stoichiometry: 1.0
species: 770345
type: SpeciesReference

778319
stoichiometry: 1.0
species: 772467
type: SpeciesReference

852464
stoichiometry: 1.0
species: 771516
type: SpeciesReference

832237
stoichiometry: 1.0
species: 766604
type: SpeciesReference

850962
value: -1000.0
type: LocalParameter

839604
stoichiometry: 1.0
species: 767088
type: SpeciesReference

775841
value: 1000.0
type: LocalParameter

840993
stoichiometry: 1.0
species: 767052
type: SpeciesReference

794464
value: -1000.0
type: LocalParameter

784723
stoichiometry: 1.0
species: 769621
type: SpeciesReference

828919
stoichiometry: 1.0
species: 766264
type: SpeciesReference

853519
stoichiometry: 1.0
species: 770237
type: SpeciesReference

824894
stoichiometry: 0.005
species: 767876
type: SpeciesReference

817922
stoichiometry: 1.0
species: 770453
type: SpeciesReference

825825
stoichiometry: 1.0
species: 768347
type: SpeciesReference

849792
kinetic law: 849840
product: 849828
product: 849816
reactant: 849804
notes: GENE_ASSOCIATION: NM_000317.1 GENE_LIST: NM_000317.1 SUBSYSTEM: Folate Metabolism
fast: false
reversible: false
name: 6-pyruvoyltetrahydropterin synthase
type: Reaction

773905
value: 1000.0
type: LocalParameter

825764
value: 0.0
type: LocalParameter

813344
stoichiometry: 1.0
species: 770165
type: SpeciesReference

809500
value: 1000.0
type: LocalParameter

835021
reactant: 835035
product: 835072
kinetic law: 835084
product: 835060
fast: false
reversible: true
reactant: 835048
notes: GENE_ASSOCIATION: NM_003562.3 GENE_LIST: NM_003562.3 SUBSYSTEM: Transport, Mitochondrial
type: Reaction
name: malate-alphaketoglutarate transporter

814400
stoichiometry: 1.0
species: 769851
type: SpeciesReference

809934
value: 1000.0
type: LocalParameter

841054
value: 0.0
type: LocalParameter

797417
value: 0.0
type: LocalParameter

832092
value: 0.0
type: LocalParameter

852731
stoichiometry: 1.0
species: 771516
type: SpeciesReference

824687
value: 0.0
type: LocalParameter

833023
value: 0.0
type: LocalParameter

819228
stoichiometry: 1.0
species: 769294
type: SpeciesReference

814508
stoichiometry: 1.0
species: 770997
type: SpeciesReference

831671
stoichiometry: 1.0
species: 767948
type: SpeciesReference

820315
stoichiometry: 1.0
species: 766604
type: SpeciesReference

802023
value: 0.0
type: LocalParameter

796239
stoichiometry: 1.0
species: 769863
type: SpeciesReference

781880
stoichiometry: 1.0
species: 766240
type: SpeciesReference

792701
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_001876.2 or NM_152359.1 or NM_004377.2 or NM_001031847.1 or NM_152247.1 or NM_152245.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
type: Reaction
product: 792751
reactant: 792713
reversible: true
product: 792738
reactant: 792725
kinetic law: 792763
name: carnitine eicosadienoyltransferase (C20:2Crn, n6)
fast: false

843677
value: -1000.0
type: LocalParameter

838312
stoichiometry: 1.0
species: 770622
type: SpeciesReference

802648
stoichiometry: 1.0
species: 768359
type: SpeciesReference

782715
stoichiometry: 0.243
species: 768825
type: SpeciesReference

816850
stoichiometry: 6.0
species: 770165
type: SpeciesReference

799135
stoichiometry: 1.0
species: 769851
type: SpeciesReference

818589
value: 0.0
type: LocalParameter

819734
stoichiometry: 3.0
species: 767767
type: SpeciesReference

791057
stoichiometry: 1.0
species: 769935
type: SpeciesReference

782253
value: 1000.0
type: LocalParameter

782192
stoichiometry: 1.0
species: 765913
type: SpeciesReference

786872
reactant: 786897
type: Reaction
name: C-14 sterol reductase, endoplasmic reticulum
reactant: 786909
product: 786921
reversible: false
reactant: 786884
kinetic law: 786945
notes: GENE_ASSOCIATION: NM_003273.1 GENE_LIST: NM_003273.1 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
product: 786933

839700
product: 839748
notes: GENE_ASSOCIATION: ((NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or NM_002513.2 or NM_005793.3 or (NM_000269.2 and NM_001018138.1) or (NM_000269.2 and NM_002512.2) or (NM_002512.2 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or (NM_001018138.1 and NM_198175.1) or (NM_001018139.1 and NM_198175.1) or NM_013330.3 or NM_197972.1) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotide Metabolism
product: 839736
name: nucleoside-diphosphate kinase (ATP:GDP)
type: Reaction
reactant: 839712
kinetic law: 839761
reactant: 839724
reversible: true
fast: false

797756
value: 1000.0
type: LocalParameter

836630
stoichiometry: 1.0
species: 767815
type: SpeciesReference

830407
stoichiometry: 1.0
species: 767851
type: SpeciesReference

799281
stoichiometry: 1.0
species: 769657
type: SpeciesReference

802131
value: 1000.0
type: LocalParameter

795091
value: 0.0
type: LocalParameter

812191
stoichiometry: 1.0
species: 767293
type: SpeciesReference

778839
value: 1000.0
type: LocalParameter

791165
stoichiometry: 1.0
species: 766616
type: SpeciesReference

811552
value: 0.0
type: LocalParameter

799558
value: -1000.0
type: LocalParameter

808981
stoichiometry: 1.0
species: 766616
type: SpeciesReference

814968
stoichiometry: 7.0
species: 770153
type: SpeciesReference

787066
stoichiometry: 1.0
species: 771504
type: SpeciesReference

789812
stoichiometry: 1.0
species: 768142
type: SpeciesReference

848775
stoichiometry: 1.0
species: 766398
type: SpeciesReference

773603
value: 0.0
type: LocalParameter

772226
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ile_L_b
type: Species

767464
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
type: Species

833577
value: 0.0
type: LocalParameter

848115
value: 1000.0
type: LocalParameter

793923
stoichiometry: 1.0
species: 769851
type: SpeciesReference

803614
stoichiometry: 2.0
species: 767779
type: SpeciesReference

854485
stoichiometry: 1.0
species: 767088
type: SpeciesReference

822963
stoichiometry: 1.0
species: 769198
type: SpeciesReference

853735
product: 853807
product: 853783
fast: false
name: NAD(P) transhydrogenase
kinetic law: 853819
product: 853795
type: Reaction
reactant: 853747
reactant: 853771
notes: GENE_ASSOCIATION: (NM_182977.1 or NM_012343.2) GENE_LIST: NM_012343.2 NM_182977.1 SUBSYSTEM: NAD Metabolism
reactant: 853759
reversible: false

811624
stoichiometry: 1.0
species: 768154
type: SpeciesReference

834530
kinetic law: 834566
product: 834554
reactant: 834542
notes: GENE_ASSOCIATION: (NM_001001438.1 or NM_002340.3) GENE_LIST: NM_001001438.1 NM_002340.3 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: false
name: lanosterol synthase, endoplasmic reticulum
type: Reaction

824012
stoichiometry: 1.0
species: 768335
type: SpeciesReference

781080
value: 0.0
type: LocalParameter

779557
stoichiometry: 1.0
species: 769464
type: SpeciesReference

812508
stoichiometry: 1.0
species: 770153
type: SpeciesReference

807175
value: -1000.0
type: LocalParameter

850816
kinetic law: 850852
product: 850840
reactant: 850828
notes: GENE_ASSOCIATION: (NM_199229.1 or NM_006916.1) GENE_LIST: NM_006916.1 NM_199229.1 SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: true
name: ribulose 5-phosphate 3-epimerase
type: Reaction

843338
value: 0.0
type: LocalParameter

808140
stoichiometry: 1.0
species: 766338
type: SpeciesReference

837490
value: 0.0
type: LocalParameter

823194
type: Reaction
notes: GENE_ASSOCIATION: (NM_000408.2 or NM_001083112.1) GENE_LIST: NM_000408.2 NM_001083112.1 SUBSYSTEM: Glycerophospholipid Metabolism
product: 823230
reactant: 823218
reversible: false
reactant: 823206
kinetic law: 823254
fast: false
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
product: 823242

785891
stoichiometry: 1.0
species: 767633
type: SpeciesReference

780271
value: 0.0
type: LocalParameter

851082
stoichiometry: 1.0
species: 771744
type: SpeciesReference

773483
stoichiometry: 1.0
species: 771864
type: SpeciesReference

851941
value: 0.0
type: LocalParameter

855117
stoichiometry: 1.0
species: 769270
type: SpeciesReference

840098
stoichiometry: 1.0
species: 766240
type: SpeciesReference

810031
stoichiometry: 1.0
species: 767306
type: SpeciesReference

810814
value: 0.0
type: LocalParameter

797828
stoichiometry: 1.0
species: 766616
type: SpeciesReference

845876
stoichiometry: 1.0
species: 765696
type: SpeciesReference

771444
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: H+
type: Species

844607
stoichiometry: 1.0
species: 767767
type: SpeciesReference

798179
stoichiometry: 1.0
species: 771009
type: SpeciesReference

848992
stoichiometry: 1.0
species: 768921
type: SpeciesReference

848520
stoichiometry: 1.0
species: 767767
type: SpeciesReference

795849
product: 795885
type: Reaction
reversible: true
kinetic law: 795909
reactant: 795861
fast: false
reactant: 795873
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
name: octadecenoyl carnitine transport (C18:1Crn, n9)
product: 795897

846952
name: inorganic diphosphatase
reversible: false
fast: false
product: 847001
kinetic law: 847013
product: 846989
type: Reaction
reactant: 846964
notes: GENE_ASSOCIATION: NM_021129.3 GENE_LIST: NM_021129.3 SUBSYSTEM: Other
reactant: 846976

798906
stoichiometry: 1.0
species: 771156
type: SpeciesReference

845113
value: -1000.0
type: LocalParameter

768957
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: O-Phospho-L-serine
type: Species

784504
value: 1000.0
type: LocalParameter

788650
value: 500.0
type: LocalParameter

765696
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Phenylalanine
type: Species

793343
stoichiometry: 1.0
species: 766628
type: SpeciesReference

825607
stoichiometry: 1.0
species: 765345
type: SpeciesReference

847025
value: 0.0
type: LocalParameter

821154
stoichiometry: 1.0
species: 768800
type: SpeciesReference

826274
value: 1000.0
type: LocalParameter

825982
stoichiometry: 1.0
species: 767621
type: SpeciesReference

812386
stoichiometry: 1.0
species: 767428
type: SpeciesReference

793235
stoichiometry: 1.0
species: 770141
type: SpeciesReference

820652
stoichiometry: 0.002
species: 766796
type: SpeciesReference

778150
value: 0.0
type: LocalParameter

843025
stoichiometry: 1.0
species: 770865
type: SpeciesReference

838240
value: 1000.0
type: LocalParameter

817705
stoichiometry: 1.0
species: 770153
type: SpeciesReference

810248
value: 0.0
type: LocalParameter

790685
stoichiometry: 1.0
species: 769863
type: SpeciesReference

769005
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Ribulose 5-phosphate
type: Species

852246
reactant: 852258
reactant: 852270
notes: SUBSYSTEM: Cysteine Metabolism
product: 852282
name: non-enzymatic reaction
product: 852294
type: Reaction
product: 852307
kinetic law: 852319
reversible: false
fast: false

808705
stoichiometry: 1.0
species: 768409
type: SpeciesReference

813027
value: 0.0
type: LocalParameter

783113
stoichiometry: 1.0
species: 766604
type: SpeciesReference

840776
value: 0.0
type: LocalParameter

830299
kinetic law: 830335
product: 830323
reactant: 830311
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hexadecenoate (C16:1, n-7) transport
type: Reaction

821888
stoichiometry: 2.0
species: 767767
type: SpeciesReference

784180
stoichiometry: 1.0
species: 768310
type: SpeciesReference

805672
value: 1000.0
type: LocalParameter

789400
value: 0.0
type: LocalParameter

819095
stoichiometry: 12.0
species: 768323
type: SpeciesReference

831395
value: 0.0
type: LocalParameter

856179
stoichiometry: 1.0
species: 770261
type: SpeciesReference

766168
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Acetate
type: Species

782036
value: 1000.0
type: LocalParameter

838531
value: 1000.0
type: LocalParameter

844125
value: 0.0
type: LocalParameter

842661
value: 0.0
type: LocalParameter

802468
stoichiometry: 1.0
species: 767767
type: SpeciesReference

799778
stoichiometry: 1.0
species: 768347
type: SpeciesReference

816560
value: 0.0
type: LocalParameter

769681
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: ADP
type: Species

816415
stoichiometry: 9.0
species: 769851
type: SpeciesReference

823072
stoichiometry: 1.0
species: 767683
type: SpeciesReference

796458
reactant: 796483
type: Reaction
name: carnitine octadecatrienoyltransferase (C18:3Crn, n3), mitochondrial
fast: false
reversible: true
product: 796495
reactant: 796471
product: 796507
kinetic law: 796519
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle

809223
value: 0.0
type: LocalParameter

777522
kinetic law: 777558
product: 777546
reactant: 777534
fast: false
reversible: true
name: octadecatrienoate (C18:3, n-3) exchange
type: Reaction

812724
stoichiometry: 1.0
species: 770622
type: SpeciesReference

803832
value: 1000.0
type: LocalParameter

827078
value: 1000.0
type: LocalParameter

846094
reactant: 846106
fast: false
reversible: true
kinetic law: 846155
notes: SUBSYSTEM: Transport, Peroxisomal
reactant: 846118
product: 846142
name: phosphate peroxisomal transport via proton symport
type: Reaction
product: 846130

770671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Ammonium
type: Species

849643
value: 0.0
type: LocalParameter

776155
value: -3.257465E-5
type: LocalParameter

777306
value: 0.0
type: LocalParameter

836738
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_001077484.1 or NM_018976.3 or NM_030674.2 or NM_007231.1) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
name: L-methionine transport in via sodium symport, blood
reversible: true
kinetic law: 836800
fast: false
product: 836788
reactant: 836751
type: Reaction
product: 836776
reactant: 836763

777233
kinetic law: 777269
product: 777257
reactant: 777245
fast: false
reversible: true
name: octadecenoate (C18:1, n-5) exchange
type: Reaction

818212
value: 0.0
type: LocalParameter

851650
stoichiometry: 1.0
species: 765768
type: SpeciesReference

787284
stoichiometry: 1.0
species: 771444
type: SpeciesReference

831455
stoichiometry: 1.0
species: 770345
type: SpeciesReference

841728
value: 0.0
type: LocalParameter

782883
stoichiometry: 1.0
species: 766228
type: SpeciesReference

786459
notes: SUBSYSTEM: Other
reversible: false
fast: false
reactant: 786471
product: 786507
type: Reaction
product: 786495
kinetic law: 786531
reactant: 786483
product: 786519
name: ATP maintenance requirment

772527
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ttdcea5_b
type: Species

781202
stoichiometry: 1.0
species: 771046
type: SpeciesReference

788770
value: 0.0
type: LocalParameter

801817
stoichiometry: 1.0
species: 768335
type: SpeciesReference

774244
stoichiometry: 1.0
species: 765249
type: SpeciesReference

835242
value: 0.0
type: LocalParameter

769803
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Citrulline
type: Species

843507
stoichiometry: 1.0
species: 765901
type: SpeciesReference

822817
product: 822853
notes: GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
product: 822865
name: fumarate transport, mitochondrial
fast: false
reversible: true
type: Reaction
reactant: 822829
reactant: 822841
kinetic law: 822877

795291
stoichiometry: 1.0
species: 768606
type: SpeciesReference

814860
stoichiometry: 8.0
species: 770333
type: SpeciesReference

840643
value: 0.0
type: LocalParameter

800540
stoichiometry: 1.0
species: 769041
type: SpeciesReference

787396
value: 500.0
type: LocalParameter

839809
value: 0.0
type: LocalParameter

765840
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Valine
type: Species

822394
stoichiometry: 1.0
species: 768800
type: SpeciesReference

767683
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: sn-Glycerol 3-phosphate
type: Species

841306
value: 0.0
type: LocalParameter

777040
kinetic law: 777076
product: 777064
reactant: 777052
fast: false
reversible: true
name: O2 exchange
type: Reaction

789060
stoichiometry: 1.0
species: 766531
type: SpeciesReference

828582
value: 0.0
type: LocalParameter

838687
type: Reaction
product: 838723
reactant: 838711
notes: GENE_ASSOCIATION: (NM_005956.2 or NM_006636.3 or NM_015440.3) GENE_LIST: NM_005956.2 NM_006636.3 NM_015440.3
product: 838735
reversible: true
reactant: 838699
fast: false
kinetic law: 838747
name: methenyltetrahydrofolate cyclohydrolase, mitochondrial

800624
value: 500.0
type: LocalParameter

793647
value: 0.0
type: LocalParameter

766058
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: Species

788880
value: 1000.0
type: LocalParameter

801927
value: 500.0
type: LocalParameter

781310
stoichiometry: 1.0
species: 769633
type: SpeciesReference

776071
kinetic law: 776107
product: 776095
reactant: 776083
fast: false
reversible: true
name: L-Histidine exchange
type: Reaction

809657
value: 0.0
type: LocalParameter

853988
stoichiometry: 1.0
species: 765575
type: SpeciesReference

777739
stoichiometry: 1.0
species: 772394
type: SpeciesReference

769899
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Dodecanoyl-CoA (n-C12:0CoA)
type: Species

780670
stoichiometry: 1.0
species: 769657
type: SpeciesReference

848263
value: 1000.0
type: LocalParameter

842552
value: 1000.0
type: LocalParameter

797308
reactant: 797332
reversible: true
type: Reaction
product: 797344
product: 797356
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
fast: false
name: octadecanoyl carnitine transport (C18:0Crn)
kinetic law: 797368
reactant: 797320

836520
stoichiometry: 1.0
species: 768238
type: SpeciesReference

786302
value: 1000.0
type: LocalParameter

767573
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Glucose 6-phosphate
type: Species

820905
stoichiometry: 0.037
species: 769294
type: SpeciesReference

774583
value: 1000.0
type: LocalParameter

774135
kinetic law: 774172
product: 774160
reactant: 774148
fast: false
reversible: true
name: docosapentaenoate (C22:5, n-3) exchange
type: Reaction

835133
value: 0.0
type: LocalParameter

806617
kinetic law: 806653
product: 806641
reactant: 806629
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: eicosenoate (C20:1, n-9) transport
type: Reaction

787175
stoichiometry: 1.0
species: 771276
type: SpeciesReference

800430
stoichiometry: 1.0
species: 766652
type: SpeciesReference

782992
stoichiometry: 1.0
species: 766276
type: SpeciesReference

772829
stoichiometry: 0.01047
species: 768046
type: SpeciesReference

829814
value: 0.0
type: LocalParameter

794728
value: 0.0
type: LocalParameter

772933
stoichiometry: 0.01628
species: 768921
type: SpeciesReference

777679
value: 0.0
type: LocalParameter

821435
value: 1000.0
type: LocalParameter

843617
value: 500.0
type: LocalParameter

799886
value: 0.0
type: LocalParameter

815330
stoichiometry: 5.0
species: 770153
type: SpeciesReference

808441
stoichiometry: 1.0
species: 767997
type: SpeciesReference

769246
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Reduced thioredoxin
type: Species

813891
stoichiometry: 1.0
species: 770997
type: SpeciesReference

839228
stoichiometry: 1.0
species: 770622
type: SpeciesReference

855784
stoichiometry: 1.0
species: 766240
type: SpeciesReference

766796
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosahexaenoate (C22:6, n-3)
type: Species

812941
stoichiometry: 1.0
species: 769887
type: SpeciesReference

796020
stoichiometry: 1.0
species: 768482
type: SpeciesReference

849343
stoichiometry: 1.0
species: 767633
type: SpeciesReference

802924
reactant: 802936
reactant: 802948
product: 803008
product: 802996
type: Reaction
reactant: 802960
fast: false
reversible: false
reactant: 802972
product: 802984
name: Palmitoyl-CoA desaturase (n-C17:0CoA -> C17:1CoA, n-8)
kinetic law: 803020
notes: GENE_ASSOCIATION: (NM_005063.4 or NM_024906.1 or NM_001037582.1) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Desaturation

837297
value: 0.0
type: LocalParameter

847254
stoichiometry: 2.0
species: 771552
type: SpeciesReference

804365
stoichiometry: 1.0
species: 767767
type: SpeciesReference

791852
type: Reaction
product: 791888
product: 791900
reactant: 791876
name: dodecanoyl carnitine transport (C12:0Crn)
reversible: true
reactant: 791864
fast: false
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 791912

791321
value: -1000.0
type: LocalParameter

842989
stoichiometry: 1.0
species: 768630
type: SpeciesReference

821996
stoichiometry: 1.0
species: 767488
type: SpeciesReference

808813
product: 808873
kinetic law: 808897
reactant: 808849
fast: false
reactant: 808837
name: fatty-acid--CoA ligase (octadecenoate, C18:1 n-7)
reactant: 808825
notes: GENE_ASSOCIATION: (NM_022977.1 or NM_203380.1 or NM_001995.2 or NM_004457.3 or NM_203372.1 or NM_016234.3 or NM_004458.1 or NM_203379.1) GENE_LIST: NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
product: 808885
type: Reaction
product: 808861
reversible: true

786169
value: -1000.0
type: LocalParameter

828883
notes: GENE_ASSOCIATION: (NM_000161.2 or NM_001024024.1) GENE_LIST: NM_000161.2 NM_001024024.1 SUBSYSTEM: Tetrahydrobiopterin
reactant: 828895
reversible: false
reactant: 828907
product: 828943
name: GTP cyclohydrolase I
kinetic law: 828955
product: 828931
type: Reaction
fast: false
product: 828919

800773
stoichiometry: 1.0
species: 766398
type: SpeciesReference

843229
stoichiometry: 1.0
species: 769440
type: SpeciesReference

844715
stoichiometry: 1.0
species: 765986
type: SpeciesReference

853844
value: 1000.0
type: LocalParameter

810188
stoichiometry: 1.0
species: 768885
type: SpeciesReference

812083
stoichiometry: 3.0
species: 767779
type: SpeciesReference

838879
value: -1000.0
type: LocalParameter

844342
stoichiometry: 1.0
species: 770634
type: SpeciesReference

771552
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Phosphate
type: Species

830853
value: 0.0
type: LocalParameter

786725
value: 500.0
type: LocalParameter

788541
value: 500.0
type: LocalParameter

795957
value: 0.0
type: LocalParameter

768094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ITP
type: Species

815606
stoichiometry: 1.0
species: 771095
type: SpeciesReference

826164
value: 0.0
type: LocalParameter

798288
stoichiometry: 1.0
species: 768837
type: SpeciesReference

803722
stoichiometry: 1.0
species: 767767
type: SpeciesReference

781190
stoichiometry: 1.0
species: 769706
type: SpeciesReference

775732
value: 0.0
type: LocalParameter

774014
value: 0.0
type: LocalParameter

807779
value: 0.0
type: LocalParameter

796665
value: 1000.0
type: LocalParameter

851904
stoichiometry: 1.0
species: 770357
type: SpeciesReference

794116
value: 1000.0
type: LocalParameter

835929
product: 835977
type: Reaction
reversible: false
fast: false
kinetic law: 836001
reactant: 835941
product: 835989
name: malic enzyme (NAD), mitochondrial
product: 835965
reactant: 835953
notes: GENE_ASSOCIATION: NM_002396.3 GENE_LIST: NM_002396.3 SUBSYSTEM: Pyruvate Metabolism

769113
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Stearoylcarnitine (C18:0Crn)
type: Species

850140
value: 0.0
type: LocalParameter

852136
stoichiometry: 2.0
species: 767767
type: SpeciesReference

829682
value: 0.0
type: LocalParameter

805464
stoichiometry: 1.0
species: 766908
type: SpeciesReference

772696
stoichiometry: 1.63E-4
species: 766821
type: SpeciesReference

772382
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ocddea6_b
type: Species

837382
value: 1000.0
type: LocalParameter

840885
kinetic law: 840921
product: 840909
reactant: 840897
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: NH3 mitochondrial transport
type: Reaction

831287
stoichiometry: 1.0
species: 766144
type: SpeciesReference

773325
value: 1000.0
type: LocalParameter

783620
stoichiometry: 1.0
species: 766313
type: SpeciesReference

773084
stoichiometry: 1.06413
species: 768800
type: SpeciesReference

828739
value: 0.0
type: LocalParameter

843787
stoichiometry: 1.0
species: 768873
type: SpeciesReference

845367
value: 1000.0
type: LocalParameter

811128
stoichiometry: 0.004
species: 767202
type: SpeciesReference

768630
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Ornithine
type: Species

805986
stoichiometry: 1.0
species: 771672
type: SpeciesReference

779667
kinetic law: 779716
product: 779704
product: 779692
reactant: 779680
notes: GENE_ASSOCIATION: NM_005891.1 GENE_LIST: NM_005891.1 SUBSYSTEM: Tryptophan metabolism
fast: false
reversible: true
name: acetyl-CoA C-acetyltransferase
type: Reaction

821583
stoichiometry: 1.0
species: 767476
type: SpeciesReference

820047
value: 1000.0
type: LocalParameter

830081
product: 830130
notes: SUBSYSTEM: Transport, Extracellular
reversible: true
type: Reaction
reactant: 830106
reactant: 830093
kinetic law: 830142
product: 830118
fast: false
name: bicarbonate transport (Na/HCO3 cotransport), blood

800261
stoichiometry: 2.0
species: 770333
type: SpeciesReference

812965
stoichiometry: 1.0
species: 770333
type: SpeciesReference

806533
stoichiometry: 1.0
species: 767164
type: SpeciesReference

791876
stoichiometry: 1.0
species: 769863
type: SpeciesReference

784969
stoichiometry: 1.0
species: 766338
type: SpeciesReference

807211
value: 0.0
type: LocalParameter

849294
value: 0.0
type: LocalParameter

791405
stoichiometry: 1.0
species: 766628
type: SpeciesReference

786410
value: -1000.0
type: LocalParameter

826324
stoichiometry: 1.0
species: 770261
type: SpeciesReference

838795
value: 0.0
type: LocalParameter

786737
notes: SUBSYSTEM: Other
fast: false
product: 786799
type: Reaction
product: 786774
reactant: 786762
reactant: 786749
kinetic law: 786811
reversible: false
name: ATPase, cytosolic
product: 786787

856203
value: -1000.0
type: LocalParameter

770309
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: sn-Glycerol 3-phosphate
type: Species

766772
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosanoyl-CoA (C22:0CoA)
type: Species

793537
value: 0.0
type: LocalParameter

779630
value: 1000.0
type: LocalParameter

831094
value: 1000.0
type: LocalParameter

804776
value: 1000.0
type: LocalParameter

814036
stoichiometry: 7.0
species: 769851
type: SpeciesReference

790385
value: -1000.0
type: LocalParameter

799995
stoichiometry: 1.0
species: 767633
type: SpeciesReference

798324
stoichiometry: 1.0
species: 771009
type: SpeciesReference

801902
value: 1000.0
type: LocalParameter

774692
value: 0.0
type: LocalParameter

821693
value: 500.0
type: LocalParameter

831899
kinetic law: 831947
product: 831935
reactant: 831923
reactant: 831911
notes: SUBSYSTEM: Tyrosine metabolism
fast: false
reversible: true
name: S-(hydroxymethyl)glutathione synthase
type: Reaction

824276
value: 0.0
type: LocalParameter

787696
value: 0.0
type: LocalParameter

829838
fast: false
product: 829874
name: carbonate dehydratase (HCO3 equilibration reaction)
reversible: true
product: 829886
kinetic law: 829898
reactant: 829862
reactant: 829850
type: Reaction
notes: GENE_ASSOCIATION: (NM_005181.2 or NM_001216.1 or NM_005182.2 or NM_001014435.1 or NM_012113.1 or NM_000067.1 or NM_000717.2 or NM_001738.1 or NM_198584.1 or NM_206925.1 or NM_001218.3) GENE_LIST: NM_000067.1 NM_000717.2 NM_001014435.1 NM_001216.1 NM_001218.3 NM_001738.1 NM_005181.2 NM_005182.2 NM_012113.1 NM_198584.1 NM_206925.1 SUBSYSTEM: Other

781442
stoichiometry: 1.0
species: 767767
type: SpeciesReference

830962
value: 0.0
type: LocalParameter

850236
value: 0.0
type: LocalParameter

853964
value: 0.0
type: LocalParameter

779704
stoichiometry: 1.0
species: 766616
type: SpeciesReference

845379
value: 0.0
type: LocalParameter

836957
value: 1000.0
type: LocalParameter

789316
kinetic law: 789352
product: 789340
reactant: 789328
notes: GENE_ASSOCIATION: (NM_080546.2 or NM_020428.2 or NM_025257.1 or NM_152369.2 or NM_001114106.1) GENE_LIST: NM_001114106.1 NM_020428.2 NM_025257.1 NM_080546.2 NM_152369.2 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Choline transport, blood
type: Reaction

829209
value: 0.0
type: LocalParameter

852573
stoichiometry: 1.0
species: 771528
type: SpeciesReference

797683
stoichiometry: 1.0
species: 768751
type: SpeciesReference

820724
stoichiometry: 0.007
species: 767177
type: SpeciesReference

789170
value: 500.0
type: LocalParameter

841814
stoichiometry: 1.0
species: 770985
type: SpeciesReference

819927
stoichiometry: 3.0
species: 767767
type: SpeciesReference

851046
stoichiometry: 1.0
species: 771816
type: SpeciesReference

828342
value: 0.0
type: LocalParameter

842442
value: 0.0
type: LocalParameter

835579
stoichiometry: 1.0
species: 768981
type: SpeciesReference

815824
value: 1000.0
type: LocalParameter

796178
value: 1000.0
type: LocalParameter

829088
value: 1000.0
type: LocalParameter

840559
stoichiometry: 1.0
species: 766398
type: SpeciesReference

840933
value: -1000.0
type: LocalParameter

801756
value: 0.0
type: LocalParameter

774002
value: 1000.0
type: LocalParameter

818152
stoichiometry: 1.0
species: 770165
type: SpeciesReference

811019
stoichiometry: 0.001
species: 766784
type: SpeciesReference

793755
value: 1000.0
type: LocalParameter

771252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 4,4-dimethylzymosterol
type: Species

777727
stoichiometry: 1.0
species: 765684
type: SpeciesReference

822538
value: 1000.0
type: LocalParameter

806400
value: 0.0
type: LocalParameter

813782
value: 0.0
type: LocalParameter

806058
value: 0.0
type: LocalParameter

832696
value: 0.0
type: LocalParameter

808945
value: 0.0
type: LocalParameter

796531
value: -1000.0
type: LocalParameter

795168
stoichiometry: 1.0
species: 770829
type: SpeciesReference

821050
value: -1000.0
type: LocalParameter

829946
value: 0.0
type: LocalParameter

843897
stoichiometry: 1.0
species: 770369
type: SpeciesReference

805599
stoichiometry: 1.0
species: 766944
type: SpeciesReference

790240
kinetic law: 790276
product: 790264
reactant: 790252
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: CO2 transport, endoplasmic reticulum
type: Reaction

813903
stoichiometry: 1.0
species: 769657
type: SpeciesReference

850526
value: 0.0
type: LocalParameter

823483
stoichiometry: 1.0
species: 770345
type: SpeciesReference

808525
reactant: 808537
reactant: 808549
product: 808597
notes: GENE_ASSOCIATION: (NM_022977.1 or NM_001995.2 or NM_004457.3 or NM_203380.1 or NM_203372.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1 or NM_015256.2 or NM_004458.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
kinetic law: 808609
reversible: true
product: 808573
reactant: 808561
fast: false
type: Reaction
product: 808585
name: fatty-acid--CoA ligase (octadecanoate)

773193
stoichiometry: 1.0
species: 771828
type: SpeciesReference

769706
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: AMP
type: Species

804353
stoichiometry: 1.0
species: 767343
type: SpeciesReference

838482
stoichiometry: 1.0
species: 769839
type: SpeciesReference

778476
value: 0.0
type: LocalParameter

810466
stoichiometry: 1.0
species: 766968
type: SpeciesReference

802936
stoichiometry: 1.0
species: 767767
type: SpeciesReference

839592
stoichiometry: 1.0
species: 767779
type: SpeciesReference

772540
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: tyr_L_b
type: Species

768070
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: myo-Inositol
type: Species

798191
stoichiometry: 1.0
species: 769863
type: SpeciesReference

767948
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: S-(Hydroxymethyl)glutathione
type: Species

839447
stoichiometry: 1.0
species: 766724
type: SpeciesReference

855892
stoichiometry: 1.0
species: 767088
type: SpeciesReference

765491
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: heptadecanoate (C17:0)
type: Species

796130
stoichiometry: 1.0
species: 769851
type: SpeciesReference

810079
value: 1000.0
type: LocalParameter

844366
value: 0.0
type: LocalParameter

809296
stoichiometry: 1.0
species: 766338
type: SpeciesReference

800515
product: 800564
name: cystathionine b-synthase
reversible: false
type: Reaction
product: 800552
kinetic law: 800576
fast: false
reactant: 800540
reactant: 800527
notes: GENE_ASSOCIATION: NM_000071.1 GENE_LIST: NM_000071.1 SUBSYSTEM: Cysteine Metabolism

796422
value: 1000.0
type: LocalParameter

834943
stoichiometry: 1.0
species: 767767
type: SpeciesReference

849816
stoichiometry: 1.0
species: 766119
type: SpeciesReference

828799
stoichiometry: 1.0
species: 767731
type: SpeciesReference

818805
value: 500.0
type: LocalParameter

847727
stoichiometry: 1.0
species: 770719
type: SpeciesReference

817874
reactant: 817922
product: 817983
reactant: 817934
reversible: false
product: 817946
product: 817959
product: 817995
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reactant: 817886
kinetic law: 818007
reactant: 817898
fast: false
reactant: 817910
product: 817971
name: Beta oxidation of odd chain fatty acid
type: Reaction

823060
fast: false
product: 823096
notes: GENE_ASSOCIATION: NM_005276.2 GENE_LIST: NM_005276.2 SUBSYSTEM: Glycerophospholipid Metabolism
type: Reaction
product: 823108
reversible: true
product: 823121
name: glycerol-3-phosphate dehydrogenase (NAD)
reactant: 823072
reactant: 823084
kinetic law: 823133

781382
value: 0.0
type: LocalParameter

774148
stoichiometry: 1.0
species: 765237
type: SpeciesReference

817729
stoichiometry: 1.0
species: 770465
type: SpeciesReference

775393
kinetic law: 775429
product: 775417
reactant: 775405
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

843001
stoichiometry: 1.0
species: 770333
type: SpeciesReference

807441
stoichiometry: 1.0
species: 769137
type: SpeciesReference

777836
stoichiometry: 1.0
species: 772406
type: SpeciesReference

769029
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Sarcosine
type: Species

792592
stoichiometry: 1.0
species: 767280
type: SpeciesReference

844823
stoichiometry: 1.0
species: 766095
type: SpeciesReference

802432
value: 0.0
type: LocalParameter

772780
stoichiometry: 5.37E-4
species: 767695
type: SpeciesReference

775514
stoichiometry: 1.0
species: 772128
type: SpeciesReference

789280
value: 1000.0
type: LocalParameter

772636
stoichiometry: 0.2784
species: 766543
type: SpeciesReference

793863
value: -1000.0
type: LocalParameter

839011
value: 1000.0
type: LocalParameter

804619
value: 1000.0
type: LocalParameter

850634
value: 0.0
type: LocalParameter

820520
stoichiometry: 1.0
species: 767779
type: SpeciesReference

770805
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecenoyl-CoA (C18:1CoA, n-7)
type: Species

784529
value: 500.0
type: LocalParameter

771468
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Lanosterol
type: Species

769815
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: cardiolipin, adipocyte
type: Species

827186
value: -1000.0
type: LocalParameter

771684
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Dimethylallyl diphosphate
type: Species

804462
value: 1000.0
type: LocalParameter

779425
value: 0.0
type: LocalParameter

838373
value: 0.0
type: LocalParameter

788782
value: 0.0
type: LocalParameter

793102
stoichiometry: 1.0
species: 766616
type: SpeciesReference

849924
stoichiometry: 1.0
species: 767767
type: SpeciesReference

781238
value: 1000.0
type: LocalParameter

840014
value: -1000.0
type: LocalParameter

797804
stoichiometry: 1.0
species: 766628
type: SpeciesReference

856141
stoichiometry: 1.0
species: 769693
type: SpeciesReference

807151
stoichiometry: 1.0
species: 765321
type: SpeciesReference

825243
value: 0.0
type: LocalParameter

846082
value: 500.0
type: LocalParameter

765382
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Glycine
type: Species

811600
product: 811708
product: 811696
reactant: 811624
product: 811684
notes: SUBSYSTEM: Fatty Acid Synthesis
reactant: 811612
kinetic law: 811732
product: 811720
reactant: 811648
product: 811672
fast: false
type: Reaction
name: fatty-acyl-CoA elongation (n-C20:3CoA, n6)
reactant: 811636
reversible: false
reactant: 811660

836726
value: 500.0
type: LocalParameter

801600
value: -1000.0
type: LocalParameter

774413
value: 500.0
type: LocalParameter

840667
fast: false
notes: GENE_ASSOCIATION: (NM_005793.3 or NM_013330.3 or NM_002513.2 or (NM_000269.2 and NM_001018138.1) or (NM_001018139.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or (NM_000269.2 and NM_002512.2) or (NM_001018138.1 and NM_198175.1) or (NM_002512.2 and NM_198175.1) or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or NM_197972.1) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotide Metabolism
type: Reaction
product: 840716
reactant: 840679
product: 840704
name: nucleoside-diphosphate kinase (ATP:dADP)
reversible: true
kinetic law: 840728
reactant: 840691

786628
stoichiometry: 1.0
species: 770985
type: SpeciesReference

841703
value: -1000.0
type: LocalParameter

782751
stoichiometry: 0.002
species: 769161
type: SpeciesReference

787540
value: 0.0
type: LocalParameter

791768
stoichiometry: 1.0
species: 766628
type: SpeciesReference

835350
value: 1000.0
type: LocalParameter

805720
stoichiometry: 1.0
species: 771684
type: SpeciesReference

833770
stoichiometry: 1.0
species: 771444
type: SpeciesReference

807368
reactant: 807405
reactant: 807393
product: 807441
notes: GENE_ASSOCIATION: (NM_022977.1 or NM_004457.3 or NM_001995.2 or NM_203379.1 or NM_015256.2 or NM_203372.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1 or NM_004458.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
name: fatty-acid--CoA ligase (tetradecanoate)
reactant: 807381
product: 807417
kinetic law: 807453
reversible: true
type: Reaction
fast: false
product: 807429

824168
value: 0.0
type: LocalParameter

836303
value: 0.0
type: LocalParameter

790493
value: 1000.0
type: LocalParameter

845840
value: 0.0
type: LocalParameter

844258
value: 500.0
type: LocalParameter

781599
value: 0.0
type: LocalParameter

833408
stoichiometry: 1.0
species: 768082
type: SpeciesReference

846349
stoichiometry: 1.0
species: 767767
type: SpeciesReference

812277
stoichiometry: 1.0
species: 767016
type: SpeciesReference

772430
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: pnto_R_b
type: Species

768897
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Inorganic triphosphate
type: Species

815318
stoichiometry: 8.0
species: 769851
type: SpeciesReference

780283
fast: false
reactant: 780307
product: 780319
product: 780331
reactant: 780295
notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reversible: true
kinetic law: 780343
type: Reaction
name: acyl-CoA dehydrogenase, mitochondrial

823326
stoichiometry: 1.0
species: 767645
type: SpeciesReference

803941
stoichiometry: 2.0
species: 767779
type: SpeciesReference

814750
value: 500.0
type: LocalParameter

830371
value: 0.0
type: LocalParameter

822975
stoichiometry: 1.0
species: 767779
type: SpeciesReference

843326
value: 1000.0
type: LocalParameter

849186
value: 0.0
type: LocalParameter

824000
stoichiometry: 1.0
species: 767767
type: SpeciesReference

766883
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dGTP
type: Species

830263
value: 1000.0
type: LocalParameter

797792
reactant: 797804
kinetic law: 797852
product: 797828
name: carnitine propionyltransferase
reversible: true
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
type: Reaction
reactant: 797816
product: 797840

795656
stoichiometry: 1.0
species: 768618
type: SpeciesReference

766276
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species

779087
stoichiometry: 1.0
species: 765962
type: SpeciesReference

778976
kinetic law: 779015
product: 779002
reactant: 778989
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

852682
name: delta24-sterol reductase
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Metabolism
reactant: 852694
type: Reaction
reactant: 852706
reversible: false
fast: false
product: 852743
kinetic law: 852755
reactant: 852719
product: 852731

821496
stoichiometry: 1.0
species: 770177
type: SpeciesReference

794838
value: 1000.0
type: LocalParameter

800936
stoichiometry: 1.0
species: 769766
type: SpeciesReference

836848
value: 0.0
type: LocalParameter

772855
stoichiometry: 0.01359
species: 768130
type: SpeciesReference

810236
value: 0.0
type: LocalParameter

815209
stoichiometry: 6.0
species: 770165
type: SpeciesReference

803674
value: 1000.0
type: LocalParameter

796287
value: -1000.0
type: LocalParameter

835072
stoichiometry: 1.0
species: 770538
type: SpeciesReference

797090
stoichiometry: 1.0
species: 769101
type: SpeciesReference

847037
value: 1000.0
type: LocalParameter

775249
value: 0.0
type: LocalParameter

819770
stoichiometry: 1.0
species: 768397
type: SpeciesReference

789424
stoichiometry: 1.0
species: 766543
type: SpeciesReference

812857
reactant: 812917
reactant: 812869
reactant: 812881
reversible: false
product: 812929
fast: false
product: 812965
product: 812953
product: 812941
reactant: 812905
product: 812977
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reactant: 812893
kinetic law: 812989
type: Reaction
name: Beta oxidation of fatty acid

785782
stoichiometry: 1.0
species: 770719
type: SpeciesReference

803080
product: 803153
type: Reaction
reactant: 803104
reversible: false
reactant: 803116
name: stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-5)
product: 803166
reactant: 803129
fast: false
reactant: 803092
notes: SUBSYSTEM: Fatty Acid Desaturation
kinetic law: 803178
product: 803141

853278
value: -1000.0
type: LocalParameter

776022
value: 0.0
type: LocalParameter

818298
stoichiometry: 1.0
species: 770345
type: SpeciesReference

799838
stoichiometry: 1.0
species: 768800
type: SpeciesReference

856361
stoichiometry: 1.0
species: 769391
type: SpeciesReference

825655
value: 1000.0
type: LocalParameter

794488
value: 0.0
type: LocalParameter

856409
value: 1000.0
type: LocalParameter

838603
stoichiometry: 1.0
species: 765852
type: SpeciesReference

775671
value: 0.0
type: LocalParameter

777582
value: 0.0
type: LocalParameter

783901
stoichiometry: 1.0
species: 768310
type: SpeciesReference

820303
stoichiometry: 2.0
species: 768335
type: SpeciesReference

785370
stoichiometry: 1.0
species: 765153
type: SpeciesReference

828239
stoichiometry: 1.0
species: 766338
type: SpeciesReference

826614
value: 0.0
type: LocalParameter

824978
stoichiometry: 0.002
species: 768666
type: SpeciesReference

847872
stoichiometry: 1.0
species: 771034
type: SpeciesReference

823711
stoichiometry: 1.0
species: 771420
type: SpeciesReference

846904
value: 0.0
type: LocalParameter

817054
stoichiometry: 10.0
species: 770634
type: SpeciesReference

785202
stoichiometry: 1.0
species: 766398
type: SpeciesReference

788044
value: 0.0
type: LocalParameter

841066
value: 1000.0
type: LocalParameter

837128
stoichiometry: 1.0
species: 770441
type: SpeciesReference

818998
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
reversible: false
kinetic law: 819119
product: 819058
product: 819083
name: fatty acid synthase (C15:0), cytosol
reactant: 819034
type: Reaction
reactant: 819022
product: 819071
reactant: 819010
reactant: 819046
product: 819095
product: 819107
fast: false

834084
stoichiometry: 1.0
species: 769597
type: SpeciesReference

848956
stoichiometry: 1.0
species: 765575
type: SpeciesReference

790505
value: 0.0
type: LocalParameter

769186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Tetrahydrobiopterin
type: Species

840231
stoichiometry: 1.0
species: 769875
type: SpeciesReference

807912
value: 1000.0
type: LocalParameter

779208
kinetic law: 779244
product: 779232
reactant: 779220
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: 6-Phospho-D-gluconate transport in/out via proton symport
type: Reaction

806641
stoichiometry: 1.0
species: 765285
type: SpeciesReference

792446
value: 0.0
type: LocalParameter

792373
stoichiometry: 1.0
species: 766616
type: SpeciesReference

815534
stoichiometry: 1.0
species: 770345
type: SpeciesReference

772214
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: hpdcea8_b
type: Species

794272
name: carnitine hexadecenoyltransferase (C16:1Crn, n7), mitochondrial
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 794308
product: 794320
reactant: 794284
reactant: 794296
fast: false
type: Reaction
reversible: true
kinetic law: 794332

855747
fast: false
type: Reaction
reactant: 855759
name: UMP kinase
reactant: 855771
notes: GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Nucleotides
product: 855796
product: 855784
kinetic law: 855808
reversible: true

819528
value: 500.0
type: LocalParameter

781165
stoichiometry: 1.0
species: 769851
type: SpeciesReference

811853
stoichiometry: 1.0
species: 769125
type: SpeciesReference

778101
kinetic law: 778138
product: 778126
reactant: 778113
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

842164
value: 0.0
type: LocalParameter

833312
stoichiometry: 1.0
species: 771684
type: SpeciesReference

811588
value: 500.0
type: LocalParameter

767241
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosenoyl-CoA (C20:1CoA, n-11)
type: Species

837962
stoichiometry: 1.0
species: 770598
type: SpeciesReference

776350
value: 500.0
type: LocalParameter

836171
value: 0.0
type: LocalParameter

765045
constant: true
size: NaN
spatial dimensions: 3.0
name: Cytoplasm
type: Compartment

786860
value: 500.0
type: LocalParameter

783464
stoichiometry: 1.0
species: 769693
type: SpeciesReference

780066
stoichiometry: 1.0
species: 767767
type: SpeciesReference

839736
stoichiometry: 1.0
species: 766240
type: SpeciesReference

766422
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: cAMP
type: Species

783729
stoichiometry: 1.0
species: 765129
type: SpeciesReference

824553
value: -1000.0
type: LocalParameter

778537
value: -1.62213E-4
type: LocalParameter

843544
stoichiometry: 1.0
species: 768323
type: SpeciesReference

792226
stoichiometry: 1.0
species: 767267
type: SpeciesReference

846759
stoichiometry: 1.0
species: 767767
type: SpeciesReference

802828
stoichiometry: 2.0
species: 767779
type: SpeciesReference

837816
stoichiometry: 1.0
species: 769851
type: SpeciesReference

833626
stoichiometry: 1.0
species: 771480
type: SpeciesReference

816040
fast: false
reactant: 816064
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.... NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
kinetic law: 816161
product: 816137
product: 816124
product: 816112
reactant: 816088
reactant: 816076
product: 816149
reversible: false
reactant: 816100
type: Reaction
reactant: 816052
name: Beta oxidation of fatty acid

830539
stoichiometry: 1.0
species: 767573
type: SpeciesReference

774571
value: 0.0
type: LocalParameter

782534
stoichiometry: 0.003
species: 767215
type: SpeciesReference

833553
value: -1000.0
type: LocalParameter

813211
value: 1000.0
type: LocalParameter

804074
stoichiometry: 1.0
species: 768359
type: SpeciesReference

848409
value: 0.0
type: LocalParameter

817319
stoichiometry: 1.0
species: 769742
type: SpeciesReference

802155
value: 0.0
type: LocalParameter

773917
value: 0.0
type: LocalParameter

791297
stoichiometry: 1.0
species: 769959
type: SpeciesReference

835688
stoichiometry: 1.0
species: 768298
type: SpeciesReference

782606
stoichiometry: 0.005
species: 767876
type: SpeciesReference

825813
stoichiometry: 1.0
species: 767633
type: SpeciesReference

845524
stoichiometry: 1.0
species: 767573
type: SpeciesReference

774292
value: 1000.0
type: LocalParameter

799111
value: 0.0
type: LocalParameter

801491
value: 0.0
type: LocalParameter

798893
stoichiometry: 1.0
species: 769851
type: SpeciesReference

767658
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Glycine
type: Species

795873
stoichiometry: 1.0
species: 769863
type: SpeciesReference

806964
value: -1000.0
type: LocalParameter

853699
value: 1000.0
type: LocalParameter

852452
stoichiometry: 1.0
species: 771456
type: SpeciesReference

785624
stoichiometry: 1.0
species: 766300
type: SpeciesReference

821278
stoichiometry: 1.0
species: 768800
type: SpeciesReference

799003
type: Reaction
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 799063
reactant: 799027
name: tetradecanoyl carnitine transport (C14:0Crn)
product: 799051
reversible: true
fast: false
product: 799039
reactant: 799015

799449
value: 1000.0
type: LocalParameter

838034
kinetic law: 838070
product: 838058
reactant: 838046
notes: GENE_ASSOCIATION: NM_000255.1 GENE_LIST: NM_000255.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: methylmalonyl-CoA mutase
type: Reaction

852307
stoichiometry: 1.0
species: 769053
type: SpeciesReference

780815
stoichiometry: 1.0
species: 768021
type: SpeciesReference

832998
value: 1000.0
type: LocalParameter

783040
value: -1000.0
type: LocalParameter

801345
value: 0.0
type: LocalParameter

771168
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: tetradecenoyl-CoA (C14:1CoA, n-5)
type: Species

788904
value: 500.0
type: LocalParameter

767202
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatetraenoate (C20:4, n-6)
type: Species

811478
stoichiometry: 1.0
species: 766604
type: SpeciesReference

793319
stoichiometry: 1.0
species: 767367
type: SpeciesReference

852001
stoichiometry: 2.0
species: 771720
type: SpeciesReference

852792
value: 0.0
type: LocalParameter

814254
stoichiometry: 1.0
species: 770393
type: SpeciesReference

798734
value: 0.0
type: LocalParameter

791621
stoichiometry: 1.0
species: 769863
type: SpeciesReference

832804
value: 1000.0
type: LocalParameter

835471
stoichiometry: 1.0
species: 770985
type: SpeciesReference

797914
type: Reaction
notes: SUBSYSTEM: Transport, Mitochondrial
product: 797950
kinetic law: 797975
name: carnitine propionyltransferase
product: 797963
reactant: 797926
reversible: true
fast: false
reactant: 797938

830647
stoichiometry: 1.0
species: 768359
type: SpeciesReference

786519
stoichiometry: 1.0
species: 768800
type: SpeciesReference

800104
stoichiometry: 4.0
species: 770201
type: SpeciesReference

765901
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 1-Pyrroline-5-carboxylate
type: Species

803384
value: 500.0
type: LocalParameter

804183
reactant: 804195
product: 804268
reactant: 804231
notes: GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Synthesis
reactant: 804207
reversible: false
name: fatty acyl-CoA desaturase (C20:3CoA, n6 -> C20:4CoA, n6)
reactant: 804219
product: 804255
type: Reaction
product: 804243
fast: false
kinetic law: 804280

803239
reactant: 803251
reversible: false
reactant: 803275
reactant: 803263
fast: false
kinetic law: 803335
reactant: 803287
name: stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-7)
product: 803323
product: 803311
type: Reaction
notes: SUBSYSTEM: Fatty Acid Desaturation
product: 803299

782956
value: 0.0
type: LocalParameter

778645
value: 0.0
type: LocalParameter

808741
stoichiometry: 1.0
species: 768885
type: SpeciesReference

824445
value: 0.0
type: LocalParameter

847581
stoichiometry: 1.0
species: 767755
type: SpeciesReference

814726
value: 1000.0
type: LocalParameter

834194
stoichiometry: 1.0
species: 768118
type: SpeciesReference

845271
value: 500.0
type: LocalParameter

827853
value: 500.0
type: LocalParameter

771816
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Sarcosine
type: Species

820941
value: 0.0
type: LocalParameter

836025
value: 1000.0
type: LocalParameter

770526
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Leucine
type: Species

818541
stoichiometry: 1.0
species: 766700
type: SpeciesReference

853543
stoichiometry: 1.0
species: 771132
type: SpeciesReference

845415
stoichiometry: 1.0
species: 765974
type: SpeciesReference

799220
value: 0.0
type: LocalParameter

822200
stoichiometry: 1.0
species: 770213
type: SpeciesReference

802600
value: 500.0
type: LocalParameter

773808
value: 1000.0
type: LocalParameter

780706
stoichiometry: 1.0
species: 769851
type: SpeciesReference

816198
value: 0.0
type: LocalParameter

787114
value: 0.0
type: LocalParameter

792140
stoichiometry: 1.0
species: 770081
type: SpeciesReference

766992
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosahexaenoyl-CoA (C22:6CoA, n-3)
type: Species

853120
stoichiometry: 1.0
species: 770225
type: SpeciesReference

821387
stoichiometry: 1.0
species: 765406
type: SpeciesReference

806278
value: 0.0
type: LocalParameter

804014
value: 500.0
type: LocalParameter

852026
stoichiometry: 1.0
species: 771744
type: SpeciesReference

835796
product: 835844
fast: false
kinetic law: 835868
notes: GENE_ASSOCIATION: NM_005918.2 GENE_LIST: NM_005918.2 SUBSYSTEM: Citrate Cycle (TCA)
name: malate dehydrogenase, mitochondrial
reactant: 835808
type: Reaction
reversible: true
product: 835832
product: 835856
reactant: 835820

825921
value: 0.0
type: LocalParameter

850454
stoichiometry: 1.0
species: 766871
type: SpeciesReference

842225
value: -1000.0
type: LocalParameter

829427
stoichiometry: 1.0
species: 767779
type: SpeciesReference

783572
value: 0.0
type: LocalParameter

788346
value: 1000.0
type: LocalParameter

813626
reversible: false
product: 813730
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM... GENE_LIST: NM... NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 813756
fast: false
type: Reaction
reactant: 813652
product: 813704
product: 813717
reactant: 813691
reactant: 813678
reactant: 813665
product: 813743
kinetic law: 813770
name: Beta oxidation of odd chain fatty acid
reactant: 813639

805828
stoichiometry: 1.0
species: 766956
type: SpeciesReference

782096
stoichiometry: 1.0
species: 766338
type: SpeciesReference

777691
value: 0.0
type: LocalParameter

852172
stoichiometry: 1.0
species: 769186
type: SpeciesReference

850744
stoichiometry: 1.0
species: 769234
type: SpeciesReference

775081
value: 0.0
type: LocalParameter

813088
stoichiometry: 1.0
species: 770345
type: SpeciesReference

798059
stoichiometry: 1.0
species: 768825
type: SpeciesReference

825546
value: 0.0
type: LocalParameter

784252
product: 784324
reactant: 784264
reversible: false
product: 784312
name: aldehyde dehydrogenase (NAD), mitochondrial
product: 784300
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_000692.3 or NM_000690.2) GENE_LIST: NM_000690.2 NM_000692.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 784288
reactant: 784276
kinetic law: 784336

778259
value: 1000.0
type: LocalParameter

854922
value: 1000.0
type: LocalParameter

790961
value: -1000.0
type: LocalParameter

780416
stoichiometry: 1.0
species: 769488
type: SpeciesReference

849707
stoichiometry: 0.001
species: 768714
type: SpeciesReference

809077
value: 0.0
type: LocalParameter

805138
stoichiometry: 1.0
species: 769198
type: SpeciesReference

832478
stoichiometry: 1.0
species: 768323
type: SpeciesReference

767500
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
type: Species

837237
stoichiometry: 1.0
species: 768070
type: SpeciesReference

814303
stoichiometry: 7.0
species: 770333
type: SpeciesReference

817163
stoichiometry: 4.0
species: 770153
type: SpeciesReference

827573
value: 1000.0
type: LocalParameter

810682
value: 0.0
type: LocalParameter

797393
value: 1000.0
type: LocalParameter

776761
stoichiometry: 1.0
species: 765563
type: SpeciesReference

786970
value: 1000.0
type: LocalParameter

855856
value: 0.0
type: LocalParameter

789884
value: 0.0
type: LocalParameter

815643
value: 1000.0
type: LocalParameter

790613
value: 1000.0
type: LocalParameter

847435
value: 500.0
type: LocalParameter

776604
value: -2.88564E-4
type: LocalParameter

790024
stoichiometry: 0.001
species: 769778
type: SpeciesReference

769549
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 3-Methylbut-2-enoyl-CoA
type: Species

854778
value: -1000.0
type: LocalParameter

792799
value: 0.0
type: LocalParameter

785358
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_007231.1 or NM_018976.3 or NM_001077484.1 or NM_030674.2) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
type: Reaction
reactant: 785370
product: 785406
reactant: 785382
reversible: true
product: 785394
fast: false
name: L-asparagine transport in via sodium symport, blood
kinetic law: 785418

855141
value: -1000.0
type: LocalParameter

826773
stoichiometry: 1.0
species: 767779
type: SpeciesReference

833204
stoichiometry: 1.0
species: 768310
type: SpeciesReference

848556
value: 0.0
type: LocalParameter

855578
stoichiometry: 1.0
species: 767633
type: SpeciesReference

772322
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ocdca_b
type: Species

822865
stoichiometry: 1.0
species: 770225
type: SpeciesReference

846649
value: -1000.0
type: LocalParameter

803518
value: 1000.0
type: LocalParameter

766131
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3,4-Dihydroxy-L-phenylalanine
type: Species

852585
stoichiometry: 1.0
species: 771516
type: SpeciesReference

773060
stoichiometry: 1.06413
species: 766240
type: SpeciesReference

853952
value: 0.0
type: LocalParameter

789304
value: 500.0
type: LocalParameter

810333
stoichiometry: 1.0
species: 768885
type: SpeciesReference

770093
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosenoyl carnitine (C20:1Crn, n9)
type: Species

836969
value: 0.0
type: LocalParameter

800839
value: -1000.0
type: LocalParameter

779643
value: 0.0
type: LocalParameter

819939
stoichiometry: 1.0
species: 768154
type: SpeciesReference

787900
stoichiometry: 2.0
species: 767779
type: SpeciesReference

797671
name: pentadecanoyl carnitine transport (C15:0Crn)
reversible: true
kinetic law: 797732
product: 797719
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
product: 797707
type: Reaction
reactant: 797695
reactant: 797683
fast: false

803530
value: 0.0
type: LocalParameter

820712
stoichiometry: 0.002
species: 767164
type: SpeciesReference

842454
value: 0.0
type: LocalParameter

822430
value: 1000.0
type: LocalParameter

856000
stoichiometry: 1.0
species: 768094
type: SpeciesReference

843738
stoichiometry: 1.0
species: 766398
type: SpeciesReference

851058
stoichiometry: 1.0
species: 771696
type: SpeciesReference

801768
value: 0.0
type: LocalParameter

796166
value: -1000.0
type: LocalParameter

815836
value: 0.0
type: LocalParameter

828943
stoichiometry: 1.0
species: 767767
type: SpeciesReference

805841
stoichiometry: 1.0
species: 766240
type: SpeciesReference

791864
stoichiometry: 1.0
species: 766858
type: SpeciesReference

807223
type: Reaction
product: 807295
product: 807283
reactant: 807247
reversible: true
product: 807271
reactant: 807259
kinetic law: 807307
name: fatty-acid--CoA ligase (dodecanoate, C12:0)
reactant: 807235
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_016234.3 or NM_004457.3 or NM_203372.1 or NM_004458.1 or NM_203379.1 or NM_203380.1 or NM_001009185.1 or NM_015256.2 or NM_022977.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
fast: false

826188
product: 826225
kinetic law: 826249
reversible: false
reactant: 826200
notes: GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Arginine and Proline Metabolism
type: Reaction
name: glutamate 5-kinase, mitochondrial
fast: false
reactant: 826213
product: 826237

767392
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Fructose 6-phosphate
type: Species

806521
kinetic law: 806557
product: 806545
reactant: 806533
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: eicosenoate (C20:1, n-11) transport
type: Reaction

828355
value: 500.0
type: LocalParameter

812953
stoichiometry: 1.0
species: 770165
type: SpeciesReference

804909
value: 1000.0
type: LocalParameter

829730
stoichiometry: 1.0
species: 770622
type: SpeciesReference

838783
value: 0.0
type: LocalParameter

786749
stoichiometry: 1.0
species: 766398
type: SpeciesReference

856215
value: 1000.0
type: LocalParameter

766760
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosanoate (n-C22:0)
type: Species

814896
value: 0.0
type: LocalParameter

791417
stoichiometry: 1.0
species: 769959
type: SpeciesReference

784956
stoichiometry: 1.0
species: 766568
type: SpeciesReference

826336
stoichiometry: 1.0
species: 770345
type: SpeciesReference

768751
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: pentadecanoylcarnitine (C15:0Crn)
type: Species

786422
value: 1000.0
type: LocalParameter

788638
value: 0.0
type: LocalParameter

821681
value: 0.0
type: LocalParameter

799983
stoichiometry: 1.0
species: 766640
type: SpeciesReference

778963
value: 500.0
type: LocalParameter

793549
product: 793597
reactant: 793573
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 793610
reversible: true
type: Reaction
product: 793585
reactant: 793561
name: carnitine eicosatrienoyltransferase (C20:3Crn, n6), mitochondrial

804764
value: 0.0
type: LocalParameter

828461
value: 0.0
type: LocalParameter

831887
value: 500.0
type: LocalParameter

824288
value: 1000.0
type: LocalParameter

814048
stoichiometry: 6.0
species: 770153
type: SpeciesReference

784408
stoichiometry: 1.0
species: 767779
type: SpeciesReference

838470
stoichiometry: 1.0
species: 769488
type: SpeciesReference

777149
stoichiometry: 1.0
species: 765611
type: SpeciesReference

811720
stoichiometry: 4.0
species: 768323
type: SpeciesReference

810478
stoichiometry: 1.0
species: 768885
type: SpeciesReference

802948
stoichiometry: 1.0
species: 767985
type: SpeciesReference

839580
stoichiometry: 1.0
species: 767076
type: SpeciesReference

853831
value: 0.0
type: LocalParameter

804341
reactant: 804353
fast: false
notes: GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Synthesis
product: 804401
reversible: false
reactant: 804365
reactant: 804377
type: Reaction
product: 804425
kinetic law: 804437
reactant: 804389
name: fatty acyl-CoA desaturase (C20:4CoA, n3 -> C20:5CoA, n3)
product: 804413

769718
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Aspartate
type: Species

773181
stoichiometry: 1.0
species: 765117
type: SpeciesReference

839435
name: nucleoside-diphosphatase (dCDP)
fast: false
reversible: false
product: 839472
type: Reaction
reactant: 839447
notes: GENE_ASSOCIATION: NM_004901.1 GENE_LIST: NM_004901.1 SUBSYSTEM: Nucleotide Metabolism
reactant: 839460
product: 839484
kinetic law: 839508
product: 839496

806290
value: 0.0
type: LocalParameter

822659
value: 0.0
type: LocalParameter

815414
stoichiometry: 8.0
species: 770634
type: SpeciesReference

799570
value: 1000.0
type: LocalParameter

786848
value: 0.0
type: LocalParameter

808537
stoichiometry: 1.0
species: 766398
type: SpeciesReference

832890
value: -1000.0
type: LocalParameter

807587
stoichiometry: 1.0
species: 769161
type: SpeciesReference

845960
product: 846021
reactant: 845972
notes: GENE_ASSOCIATION: NM_006319.3 GENE_LIST: NM_006319.3 SUBSYSTEM: Phospholipid Metabolism
reversible: false
product: 845997
fast: false
reactant: 845985
type: Reaction
kinetic law: 846033
product: 846009
name: phosphatidylinositol synthase, human adipocyte

828895
stoichiometry: 1.0
species: 767755
type: SpeciesReference

800527
stoichiometry: 1.0
species: 767815
type: SpeciesReference

855880
stoichiometry: 1.0
species: 766398
type: SpeciesReference

765189
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: CO2
type: Species

809284
stoichiometry: 1.0
species: 768446
type: SpeciesReference

766568
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Citrulline
type: Species

813794
value: 1000.0
type: LocalParameter

777715
kinetic law: 777751
product: 777739
reactant: 777727
fast: false
reversible: true
name: ocosatetraenoate (C22:4, n-6) exchange
type: Reaction

821595
stoichiometry: 1.0
species: 767779
type: SpeciesReference

818164
stoichiometry: 1.0
species: 770333
type: SpeciesReference

811007
stoichiometry: 1.0
species: 766616
type: SpeciesReference

771264
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 4-Methylzymosterol intermediate 1
type: Species

793767
value: 0.0
type: LocalParameter

843884
stoichiometry: 1.0
species: 769730
type: SpeciesReference

795067
value: -1000.0
type: LocalParameter

796543
value: 1000.0
type: LocalParameter

829958
type: Reaction
name: HCO3 equilibration reaction, mitochondrial
kinetic law: 830019
reactant: 829970
fast: false
reversible: true
reactant: 829982
product: 830006
notes: GENE_ASSOCIATION: (NM_001739.1 or NM_007220.2) GENE_LIST: NM_001739.1 NM_007220.2 SUBSYSTEM: Central Metabolism
product: 829994

832684
value: 1000.0
type: LocalParameter

807659
fast: false
reversible: true
reactant: 807683
name: fatty-acid--CoA ligase (heptadecanoate, C15:0)
kinetic law: 807743
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203372.1 or NM_203379.1 or NM_015256.2 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
type: Reaction
product: 807731
reactant: 807671
product: 807719
product: 807707
reactant: 807695

824990
stoichiometry: 0.003
species: 768739
type: SpeciesReference

808957
name: fatty-acid--CoA ligase (octadecenoate, C18:1 n-9)
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_001995.2 or NM_004457.3 or NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_022977.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reactant: 808969
fast: false
product: 809017
kinetic law: 809041
reactant: 808993
product: 809029
product: 809005
reactant: 808981

778489
kinetic law: 778525
product: 778513
reactant: 778501
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

843121
stoichiometry: 1.0
species: 768885
type: SpeciesReference

768178
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Methionine
type: Species

791081
value: -1000.0
type: LocalParameter

848311
stoichiometry: 1.0
species: 766398
type: SpeciesReference

790252
stoichiometry: 1.0
species: 766604
type: SpeciesReference

805587
reversible: false
product: 805636
reactant: 805612
name: dimethylallyltranstransferase
type: Reaction
kinetic law: 805648
reactant: 805599
fast: false
notes: GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Biosynthesis
product: 805624

855480
value: 0.0
type: LocalParameter

823471
stoichiometry: 1.0
species: 770333
type: SpeciesReference

850538
value: 500.0
type: LocalParameter

821063
value: 1000.0
type: LocalParameter

789183
reactant: 789195
product: 789232
type: Reaction
product: 789220
notes: GENE_ASSOCIATION: (NM_212469.1 or NM_001277.2 or NM_152253.1 or NM_005198.3) GENE_LIST: NM_001277.2 NM_005198.3 NM_152253.1 NM_212469.1 SUBSYSTEM: Phospholipid Metabolism
fast: false
product: 789244
reversible: false
name: Choline kinase
reactant: 789208
kinetic law: 789256

827707
value: 0.0
type: LocalParameter

784516
value: 0.0
type: LocalParameter

846661
value: 1000.0
type: LocalParameter

847169
value: 1000.0
type: LocalParameter

786957
value: 0.0
type: LocalParameter

771058
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Pentanoyl-CoA (C5:0CoA)
type: Species

850646
value: 1000.0
type: LocalParameter

771696
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Formaldehyde
type: Species

850008
value: 0.0
type: LocalParameter

779413
value: 1000.0
type: LocalParameter

804450
value: 0.0
type: LocalParameter

827198
value: 1000.0
type: LocalParameter

769827
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: CMP
type: Species

815992
value: 0.0
type: LocalParameter

822768
value: -1000.0
type: LocalParameter

776459
kinetic law: 776495
product: 776483
reactant: 776471
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

770997
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species

797816
stoichiometry: 1.0
species: 768873
type: SpeciesReference

775502
stoichiometry: 1.0
species: 765406
type: SpeciesReference

849912
stoichiometry: 1.0
species: 766398
type: SpeciesReference

781226
value: 0.0
type: LocalParameter

848422
value: 1000.0
type: LocalParameter

836714
value: 0.0
type: LocalParameter

823940
value: 500.0
type: LocalParameter

811612
stoichiometry: 5.0
species: 767767
type: SpeciesReference

777257
stoichiometry: 1.0
species: 772334
type: SpeciesReference

765394
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Glycerol
type: Species

825231
value: 1000.0
type: LocalParameter

846070
value: 0.0
type: LocalParameter

817886
stoichiometry: 1.0
species: 769851
type: SpeciesReference

847715
stoichiometry: 1.0
species: 770321
type: SpeciesReference

781370
value: 0.0
type: LocalParameter

809392
product: 809452
product: 809440
name: fatty-acid--CoA ligase (eicosanoate, C20:0)
reactant: 809428
kinetic law: 809476
reversible: true
reactant: 809404
product: 809464
reactant: 809416
type: Reaction
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203372.1 or NM_016234.3 or NM_001009185.1 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_203380.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
fast: false

834290
stoichiometry: 1.0
species: 770526
type: SpeciesReference

796434
value: 0.0
type: LocalParameter

849804
stoichiometry: 1.0
species: 766264
type: SpeciesReference

788795
fast: false
type: Reaction
product: 788843
product: 788831
reactant: 788819
reactant: 788807
name: Ceramide cholinephosphotransferase, adipocyte
kinetic law: 788855
reversible: false
notes: SUBSYSTEM: Sphingolipid Metabolism

828787
stoichiometry: 1.0
species: 767791
type: SpeciesReference

844835
stoichiometry: 1.0
species: 768323
type: SpeciesReference

833108
value: 1000.0
type: LocalParameter

769017
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Sedoheptulose 7-phosphate
type: Species

802444
value: 0.0
type: LocalParameter

775381
value: 500.0
type: LocalParameter

843013
stoichiometry: 1.0
species: 767767
type: SpeciesReference

856154
stoichiometry: 1.0
species: 771228
type: SpeciesReference

777824
stoichiometry: 1.0
species: 765696
type: SpeciesReference

778271
value: 0.0
type: LocalParameter

789292
value: 0.0
type: LocalParameter

837696
value: 0.0
type: LocalParameter

834930
stoichiometry: 1.0
species: 767670
type: SpeciesReference

800684
stoichiometry: 1.0
species: 768286
type: SpeciesReference

804607
value: 0.0
type: LocalParameter

805696
value: 500.0
type: LocalParameter

793875
value: 1000.0
type: LocalParameter

839023
value: 0.0
type: LocalParameter

772624
stoichiometry: 1.06415
species: 766398
type: SpeciesReference

820869
stoichiometry: 0.159
species: 768458
type: SpeciesReference

797780
value: 0.0
type: LocalParameter

766288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
type: Species

779099
stoichiometry: 1.0
species: 767767
type: SpeciesReference

795644
stoichiometry: 1.0
species: 766616
type: SpeciesReference

830275
value: 0.0
type: LocalParameter

783137
stoichiometry: 1.0
species: 767767
type: SpeciesReference

766871
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dGDP
type: Species

785903
stoichiometry: 1.0
species: 769089
type: SpeciesReference

794826
value: -1000.0
type: LocalParameter

777402
value: 0.0
type: LocalParameter

821484
stoichiometry: 1.0
species: 767452
type: SpeciesReference

812131
value: 0.0
type: LocalParameter

810224
value: 1000.0
type: LocalParameter

846493
stoichiometry: 1.0
species: 770333
type: SpeciesReference

852694
stoichiometry: 1.0
species: 771444
type: SpeciesReference

847049
value: 0.0
type: LocalParameter

812845
value: 500.0
type: LocalParameter

800799
stoichiometry: 1.0
species: 766240
type: SpeciesReference

789412
kinetic law: 789449
product: 789437
reactant: 789424
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: Cholesterol transport, endoplasmic reticulum
type: Reaction

803686
value: 0.0
type: LocalParameter

836460
value: 500.0
type: LocalParameter

787552
value: 500.0
type: LocalParameter

782763
stoichiometry: 1.0
species: 766616
type: SpeciesReference

791756
stoichiometry: 1.0
species: 769863
type: SpeciesReference

831779
value: 0.0
type: LocalParameter

805732
stoichiometry: 1.0
species: 766944
type: SpeciesReference

833782
stoichiometry: 1.0
species: 771480
type: SpeciesReference

774401
value: 0.0
type: LocalParameter

840679
stoichiometry: 1.0
species: 766398
type: SpeciesReference

801612
value: 1000.0
type: LocalParameter

844246
value: 0.0
type: LocalParameter

790481
value: -1000.0
type: LocalParameter

845852
value: 500.0
type: LocalParameter

836315
value: 0.0
type: LocalParameter

815306
type: Reaction
reactant: 815342
product: 815390
fast: false
product: 815378
kinetic law: 815426
product: 815414
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_... GENE_LIST: NM_... NM_000018.2 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 815318
reactant: 815354
reversible: false
name: Beta oxidation of fatty acid
reactant: 815330
reactant: 815366
product: 815402

780295
stoichiometry: 1.0
species: 770153
type: SpeciesReference

846337
type: Reaction
name: phosphate transporter, endoplasmic reticulum
product: 846373
reactant: 846361
fast: false
reversible: true
reactant: 846349
notes: GENE_ASSOCIATION: (NM_006632.3 or NM_001098486.1 or NM_020309.2) GENE_LIST: NM_001098486.1 NM_006632.3 NM_020309.2 SUBSYSTEM: Transport, Endoplasmic Reticular
kinetic law: 846397
product: 846385

841716
value: 1000.0
type: LocalParameter

812289
stoichiometry: 3.0
species: 767779
type: SpeciesReference

830383
value: 0.0
type: LocalParameter

843314
value: 0.0
type: LocalParameter

849198
notes: GENE_ASSOCIATION: NM_014338.3 GENE_LIST: NM_014338.3 SUBSYSTEM: Phospholipid Metabolism
product: 849246
type: Reaction
reactant: 849210
reactant: 849222
fast: false
name: phosphatidylserine decarboxylase, human adipocyte
product: 849234
reversible: false
kinetic law: 849258

822987
stoichiometry: 1.0
species: 768238
type: SpeciesReference

823314
notes: SUBSYSTEM: Proline Metabolism
type: Reaction
name: L-glutamate 5-semialdehyde dehydratase (spontaneous)
product: 823362
fast: false
reactant: 823326
product: 823338
reversible: true
product: 823350
kinetic law: 823374

796118
stoichiometry: 1.0
species: 770744
type: SpeciesReference

807381
stoichiometry: 1.0
species: 766398
type: SpeciesReference

842006
stoichiometry: 1.0
species: 765623
type: SpeciesReference

839870
stoichiometry: 1.0
species: 770321
type: SpeciesReference

792458
reversible: true
product: 792507
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine eicosenoyltransferase (C20:1Crn, n9), mitochondrial
type: Reaction
product: 792495
reactant: 792483
reactant: 792470
kinetic law: 792519
fast: false

794284
stoichiometry: 1.0
species: 769863
type: SpeciesReference

821815
value: 0.0
type: LocalParameter

855735
value: 0.0
type: LocalParameter

780935
value: -1000.0
type: LocalParameter

781153
stoichiometry: 1.0
species: 769730
type: SpeciesReference

815522
stoichiometry: 1.0
species: 770153
type: SpeciesReference

781008
stoichiometry: 1.0
species: 766398
type: SpeciesReference

772202
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: hpdca_b
type: Species

784844
stoichiometry: 1.0
species: 767537
type: SpeciesReference

811576
value: 0.0
type: LocalParameter

811841
stoichiometry: 1.0
species: 768359
type: SpeciesReference

778113
stoichiometry: 1.0
species: 765732
type: SpeciesReference

766410
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Butyrate
type: Species

839724
stoichiometry: 1.0
species: 767597
type: SpeciesReference

842152
value: 0.0
type: LocalParameter

831911
stoichiometry: 1.0
species: 767428
type: SpeciesReference

780078
stoichiometry: 1.0
species: 768154
type: SpeciesReference

850864
value: -1000.0
type: LocalParameter

767803
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Bicarbonate
type: Species

783476
stoichiometry: 1.0
species: 769851
type: SpeciesReference

837950
stoichiometry: 1.0
species: 770610
type: SpeciesReference

854340
name: thymidine kinase (ATP:thymidine)
kinetic law: 854412
product: 854376
type: Reaction
product: 854388
notes: GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Nucleotide Metabolism
reactant: 854352
fast: false
reversible: false
product: 854400
reactant: 854364

839241
stoichiometry: 1.0
species: 771082
type: SpeciesReference

828130
value: -1000.0
type: LocalParameter

777594
value: 0.0
type: LocalParameter

825667
value: 0.0
type: LocalParameter

818286
stoichiometry: 1.0
species: 770153
type: SpeciesReference

772842
stoichiometry: 0.02076
species: 768118
type: SpeciesReference

837539
stoichiometry: 1.0
species: 770562
type: SpeciesReference

799826
stoichiometry: 2.0
species: 767767
type: SpeciesReference

856373
stoichiometry: 1.0
species: 771228
type: SpeciesReference

826602
value: 0.0
type: LocalParameter

813369
stoichiometry: 1.0
species: 770634
type: SpeciesReference

775683
kinetic law: 775720
product: 775708
reactant: 775695
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

838615
stoichiometry: 1.0
species: 767767
type: SpeciesReference

832249
stoichiometry: 1.0
species: 767912
type: SpeciesReference

817042
stoichiometry: 10.0
species: 770333
type: SpeciesReference

826481
stoichiometry: 1.0
species: 770261
type: SpeciesReference

841078
value: 0.0
type: LocalParameter

780610
value: 0.0
type: LocalParameter

806070
value: 500.0
type: LocalParameter

818986
value: 500.0
type: LocalParameter

792386
stoichiometry: 1.0
species: 767280
type: SpeciesReference

823723
stoichiometry: 1.0
species: 771456
type: SpeciesReference

847860
stoichiometry: 1.0
species: 770369
type: SpeciesReference

838903
value: 0.0
type: LocalParameter

809174
stoichiometry: 1.0
species: 768885
type: SpeciesReference

796981
stoichiometry: 1.0
species: 766628
type: SpeciesReference

807900
value: -1000.0
type: LocalParameter

855045
value: 0.0
type: LocalParameter

769174
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: tetradecenoyl carnitine (C14:1Crn, n-5)
type: Species

834072
stoichiometry: 1.0
species: 770526
type: SpeciesReference

790517
value: 0.0
type: LocalParameter

832189
value: 0.0
type: LocalParameter

848968
stoichiometry: 1.0
species: 765732
type: SpeciesReference

768310
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Nicotinamide adenine dinucleotide - reduced
type: Species

791285
stoichiometry: 1.0
species: 769851
type: SpeciesReference

782618
stoichiometry: 0.003
species: 767997
type: SpeciesReference

825801
stoichiometry: 1.0
species: 766398
type: SpeciesReference

845512
stoichiometry: 1.0
species: 767549
type: SpeciesReference

822321
type: Reaction
reversible: true
product: 822370
reactant: 822357
product: 822394
reactant: 822345
fast: false
notes: SUBSYSTEM: Folate Metabolism
reactant: 822333
name: formate-tetrahydrofolate ligase
kinetic law: 822406
product: 822382

773929
value: 500.0
type: LocalParameter

835591
stoichiometry: 1.0
species: 769282
type: SpeciesReference

795861
stoichiometry: 1.0
species: 768618
type: SpeciesReference

792020
stoichiometry: 1.0
species: 767267
type: SpeciesReference

805404
value: -1000.0
type: LocalParameter

824870
stoichiometry: 1.0
species: 767683
type: SpeciesReference

821266
stoichiometry: 1.0
species: 767392
type: SpeciesReference

818661
stoichiometry: 3.0
species: 767767
type: SpeciesReference

838046
stoichiometry: 1.0
species: 770598
type: SpeciesReference

799437
value: -1000.0
type: LocalParameter

853687
value: -1000.0
type: LocalParameter

785636
stoichiometry: 1.0
species: 766386
type: SpeciesReference

852440
stoichiometry: 1.0
species: 771324
type: SpeciesReference

814158
value: 0.0
type: LocalParameter

840342
stoichiometry: 1.0
species: 766240
type: SpeciesReference

845391
value: 500.0
type: LocalParameter

801357
value: 1000.0
type: LocalParameter

787259
value: 500.0
type: LocalParameter

772104
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: glyc_b
type: Species

843532
stoichiometry: 1.0
species: 768335
type: SpeciesReference

829620
stoichiometry: 1.0
species: 767779
type: SpeciesReference

792238
stoichiometry: 1.0
species: 769863
type: SpeciesReference

837804
reactant: 837840
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
product: 837864
reactant: 837828
reversible: false
type: Reaction
name: (S)-methylmalonyl-CoA hydrolase
reactant: 837816
product: 837852
fast: false
kinetic law: 837876

784107
notes: GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Cholesterol Metabolism
reversible: false
reactant: 784144
type: Reaction
name: aldehyde dehydrogenase (acetaldehyde, NAD)
fast: false
reactant: 784132
product: 784180
product: 784156
reactant: 784120
kinetic law: 784192
product: 784168

783717
name: Alanine-Sodium symporter, blood
product: 783766
fast: false
reactant: 783741
reactant: 783729
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_005628.1 or NM_003038.2) GENE_LIST: NM_003038.2 NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
reversible: true
product: 783754
kinetic law: 783778
type: Reaction

833565
value: 1000.0
type: LocalParameter

782546
stoichiometry: 0.002
species: 767241
type: SpeciesReference

833638
stoichiometry: 1.0
species: 771504
type: SpeciesReference

841934
value: -1000.0
type: LocalParameter

775938
value: 1000.0
type: LocalParameter

768202
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: (R)-Mevalonate
type: Species

802720
value: 0.0
type: LocalParameter

804086
stoichiometry: 1.0
species: 767254
type: SpeciesReference

802143
value: 0.0
type: LocalParameter

813223
value: 0.0
type: LocalParameter

817307
reactant: 817368
reactant: 817319
reactant: 817331
product: 817404
reactant: 817344
name: Beta oxidation of fatty acid
kinetic law: 817428
product: 817392
product: 817380
notes: GENE_ASSOCIATION: ((NM_000017.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2)) GENE_LIST: NM_000016.2 NM_000017.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
type: Reaction
reactant: 817356
reversible: false
fast: false
product: 817416

782338
stoichiometry: 1.0
species: 766712
type: SpeciesReference

841612
value: 1000.0
type: LocalParameter

800249
stoichiometry: 2.0
species: 770189
type: SpeciesReference

836013
value: 0.0
type: LocalParameter

814714
value: 0.0
type: LocalParameter

834182
stoichiometry: 1.0
species: 765539
type: SpeciesReference

845283
type: Reaction
product: 845331
name: 6-phosphogluconolactonase, endoplasmic reticulum
kinetic law: 845343
notes: GENE_ASSOCIATION: NM_004285.3 GENE_LIST: NM_004285.3 SUBSYSTEM: Pentose Phosphate Pathway
reversible: false
product: 845319
reactant: 845307
reactant: 845295
fast: false

842381
stoichiometry: 1.0
species: 765672
type: SpeciesReference

771804
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Phosphate
type: Species

827865
notes: GENE_ASSOCIATION: (NM_001077484.1 or NM_007231.1 or NM_018018.2 or NM_030674.2 or NM_018976.3) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
reversible: true
name: glycine reversible transport via sodium symport, blood
reactant: 827889
fast: false
reactant: 827877
type: Reaction
kinetic law: 827925
product: 827901
product: 827913

802612
reactant: 802648
notes: GENE_ASSOCIATION: (NM_005063.4 or NM_001037582.1 or NM_024906.1) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Desaturation
product: 802696
reversible: false
reactant: 802624
type: Reaction
reactant: 802636
kinetic law: 802708
product: 802672
name: Palmitoyl-CoA desaturase (n-C16:0CoA -> C16:1CoA, n-7)
fast: false
product: 802684
reactant: 802660

853531
stoichiometry: 1.0
species: 770985
type: SpeciesReference

845403
kinetic law: 845439
product: 845427
reactant: 845415
notes: GENE_ASSOCIATION: (NM_199186.1 or NM_001724.3 or NM_000290.2 or NM_001029891.2 or NM_002629.2) GENE_LIST: NM_000290.2 NM_001029891.2 NM_001724.3 NM_002629.2 NM_199186.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: phosphoglycerate mutase
type: Reaction

822212
stoichiometry: 1.0
species: 771192
type: SpeciesReference

818553
stoichiometry: 1.0
species: 767779
type: SpeciesReference

770513
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Isovaleryl-CoA
type: Species

799329
value: 1000.0
type: LocalParameter

787102
value: 1000.0
type: LocalParameter

766980
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosenoyl carnitine (C22:1Crn, n-9)
type: Species

836860
product: 836921
fast: false
notes: GENE_ASSOCIATION: NM_000431.1 GENE_LIST: NM_000431.1 SUBSYSTEM: Cholesterol Metabolism
reactant: 836884
kinetic law: 836933
product: 836909
name: mevalonate kinase (atp)
product: 836896
type: Reaction
reversible: false
reactant: 836872

780718
stoichiometry: 1.0
species: 770333
type: SpeciesReference

785080
kinetic law: 785117
product: 785105
reactant: 785093
notes: GENE_ASSOCIATION: (NM_003486.5 or NM_012244.2 or NM_018018.2 or NM_032803.3 or NM_003045.3 or NM_001048164.1 or NM_003046.2 or NM_001008539.1 or NM_001126106.1 or NM_001126105.1 or NM_182728.1 or NM_003982.3) GENE_LIST: NM_001008539.1 NM_001048164.1 NM_001126105.1 NM_001126106.1 NM_003045.3 NM_003046.2 NM_003486.5 NM_003982.3 NM_012244.2 NM_018018.2 NM_032803.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Arginine transport, blood
type: Reaction

840451
stoichiometry: 1.0
species: 766871
type: SpeciesReference

852038
stoichiometry: 1.0
species: 771780
type: SpeciesReference

850442
stoichiometry: 1.0
species: 769246
type: SpeciesReference

842237
value: 1000.0
type: LocalParameter

829415
kinetic law: 829451
product: 829439
reactant: 829427
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: H2O endoplasmic reticulum transport
type: Reaction

821375
stoichiometry: 1.0
species: 767767
type: SpeciesReference

804026
fast: false
reactant: 804038
product: 804086
reactant: 804050
product: 804110
reactant: 804074
type: Reaction
kinetic law: 804122
reversible: false
reactant: 804062
name: stearoyl-CoA desaturase (n-C20:0CoA -> C20:1CoA, n-9)
notes: SUBSYSTEM: Fatty Acid Synthesis
product: 804098

825510
stoichiometry: 1.0
species: 768800
type: SpeciesReference

779909
stoichiometry: 1.0
species: 767767
type: SpeciesReference

814738
value: 0.0
type: LocalParameter

816185
value: 1000.0
type: LocalParameter

786641
stoichiometry: 1.0
species: 769730
type: SpeciesReference

771156
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: tetradecanoylcarnitine (C14:0Crn)
type: Species

814266
stoichiometry: 7.0
species: 770622
type: SpeciesReference

783608
stoichiometry: 1.0
species: 766300
type: SpeciesReference

812520
stoichiometry: 1.0
species: 770345
type: SpeciesReference

791633
stoichiometry: 1.0
species: 769971
type: SpeciesReference

848690
stoichiometry: 1.0
species: 768800
type: SpeciesReference

798746
value: 0.0
type: LocalParameter

779860
value: 0.0
type: LocalParameter

829511
kinetic law: 829548
product: 829536
reactant: 829523
notes: GENE_ASSOCIATION: NM_001169.2 GENE_LIST: NM_001169.2 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: true
name: H2O transport, mitochondrial
type: Reaction

852013
stoichiometry: 2.0
species: 771792
type: SpeciesReference

811466
stoichiometry: 1.0
species: 768470
type: SpeciesReference

803396
fast: false
reversible: false
kinetic law: 803494
reactant: 803432
reactant: 803420
product: 803482
reactant: 803445
type: Reaction
product: 803457
notes: GENE_ASSOCIATION: (NM_005063.4 or NM_001037582.1 or NM_024906.1) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Desaturation
name: stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-9), adipocyte
product: 803469
reactant: 803408

797926
stoichiometry: 1.0
species: 768726
type: SpeciesReference

825389
kinetic law: 825426
product: 825414
reactant: 825402
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: glycerol-3-phosphate transport, mitochondrial
type: Reaction

830659
stoichiometry: 1.0
species: 766022
type: SpeciesReference

798482
value: 1000.0
type: LocalParameter

806977
value: 1000.0
type: LocalParameter

832816
value: 0.0
type: LocalParameter

817416
stoichiometry: 1.0
species: 770634
type: SpeciesReference

824433
value: 0.0
type: LocalParameter

847593
stoichiometry: 1.0
species: 768385
type: SpeciesReference

835338
value: -1000.0
type: LocalParameter

804195
stoichiometry: 1.0
species: 767306
type: SpeciesReference

782968
reactant: 782980
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
product: 783004
notes: GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: true
type: Reaction
product: 783016
reactant: 782992
kinetic law: 783028

778633
value: -1.87510999999999E-5
type: LocalParameter

776616
value: 0.0
type: LocalParameter

790625
value: 0.0
type: LocalParameter

769440
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 1-Pyrroline-5-carboxylate
type: Species

855844
value: 0.0
type: LocalParameter

847447
type: Reaction
reversible: false
product: 847484
notes: GENE_ASSOCIATION: NM_021823.3 GENE_LIST: NM_021823.3 SUBSYSTEM: CoA Biosynthesis
product: 847496
reactant: 847459
kinetic law: 847508
reactant: 847471
name: phosphopantothenoylcysteine decarboxylase
fast: false

789872
value: 1000.0
type: LocalParameter

776773
stoichiometry: 1.0
species: 772274
type: SpeciesReference

785346
value: 500.0
type: LocalParameter

833216
stoichiometry: 1.0
species: 769404
type: SpeciesReference

797236
stoichiometry: 1.0
species: 771095
type: SpeciesReference

826761
stoichiometry: 1.0
species: 767621
type: SpeciesReference

855153
value: 1000.0
type: LocalParameter

854097
fast: false
reversible: true
product: 854134
type: Reaction
notes: GENE_ASSOCIATION: (NM_032136.3 or NM_001064.1 or NM_012253.2) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
kinetic law: 854159
reactant: 854109
name: transketolase
product: 854146
reactant: 854122

790036
stoichiometry: 0.001
species: 770961
type: SpeciesReference

811999
stoichiometry: 1.0
species: 767355
type: SpeciesReference

813639
stoichiometry: 1.0
species: 769851
type: SpeciesReference

789728
value: 1000.0
type: LocalParameter

797380
value: -1000.0
type: LocalParameter

772310
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: o2_b
type: Species

848201
stoichiometry: 1.0
species: 769706
type: SpeciesReference

807003
value: 0.0
type: LocalParameter

839131
value: 1000.0
type: LocalParameter

825098
value: 1000.0
type: LocalParameter

771480
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Lathosterol
type: Species

790108
value: 1000.0
type: LocalParameter

854231
stoichiometry: 1.0
species: 767100
type: SpeciesReference

828679
stoichiometry: 2.0
species: 767743
type: SpeciesReference

796871
stoichiometry: 1.0
species: 770889
type: SpeciesReference

788358
value: 0.0
type: LocalParameter

783584
value: 500.0
type: LocalParameter

854910
value: 0.0
type: LocalParameter

780404
name: acyl-CoA dehydrogenase, mitochondrial
product: 780452
reversible: true
product: 780440
reactant: 780428
reactant: 780416
fast: false
kinetic law: 780464
type: Reaction
notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation

784264
stoichiometry: 1.0
species: 770345
type: SpeciesReference

819312
value: 0.0
type: LocalParameter

813076
stoichiometry: 1.0
species: 770153
type: SpeciesReference

825558
value: 1000.0
type: LocalParameter

793984
value: -1000.0
type: LocalParameter

848811
stoichiometry: 1.0
species: 767779
type: SpeciesReference

837249
stoichiometry: 1.0
species: 768800
type: SpeciesReference

767512
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
type: Species

814315
stoichiometry: 7.0
species: 770634
type: SpeciesReference

795499
stoichiometry: 1.0
species: 768606
type: SpeciesReference

809065
value: 1000.0
type: LocalParameter

840110
stoichiometry: 1.0
species: 766640
type: SpeciesReference

833843
stoichiometry: 1.0
species: 771516
type: SpeciesReference

832466
stoichiometry: 1.0
species: 768021
type: SpeciesReference

843957
stoichiometry: 1.0
species: 770985
type: SpeciesReference

810694
reactant: 810706
reactant: 810730
fast: false
reversible: true
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203372.1 or NM_203380.1 or NM_015256.2 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
kinetic law: 810778
type: Reaction
reactant: 810718
product: 810742
product: 810766
name: fatty-acid--CoA ligase (docosapentaenoate, C22:5 n-3)
product: 810754

772998
stoichiometry: 8.15E-4
species: 769258
type: SpeciesReference

805126
stoichiometry: 1.0
species: 768323
type: SpeciesReference

780501
value: 0.0
type: LocalParameter

815630
value: 0.0
type: LocalParameter

832032
stoichiometry: 1.0
species: 767960
type: SpeciesReference

797502
value: -1000.0
type: LocalParameter

817151
stoichiometry: 1.0
species: 769947
type: SpeciesReference

814460
stoichiometry: 1.0
species: 769657
type: SpeciesReference

827561
value: -1000.0
type: LocalParameter

817741
stoichiometry: 1.0
species: 770622
type: SpeciesReference

808969
stoichiometry: 1.0
species: 766398
type: SpeciesReference

796555
value: 0.0
type: LocalParameter

808729
stoichiometry: 1.0
species: 768556
type: SpeciesReference

829922
value: 1000.0
type: LocalParameter

851818
value: 0.0
type: LocalParameter

795031
stoichiometry: 1.0
species: 769851
type: SpeciesReference

843872
fast: false
kinetic law: 843969
reactant: 843909
name: pyruvate carboxylase, mitochondrial
product: 843945
notes: GENE_ASSOCIATION: (NM_022172.1 or NM_000920.2 or NM_001040716.1) GENE_LIST: NM_000920.2 NM_001040716.1 NM_022172.1 SUBSYSTEM: Pyruvate Metabolism
reversible: false
product: 843921
product: 843957
type: Reaction
reactant: 843897
product: 843933
reactant: 843884

817440
value: 0.0
type: LocalParameter

771276
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 4-Methylzymosterol intermediate 2
type: Species

772768
stoichiometry: 0.03261
species: 767658
type: SpeciesReference

777703
value: -0.00343343205
type: LocalParameter

821180
value: 0.0
type: LocalParameter

816814
stoichiometry: 10.0
species: 770622
type: SpeciesReference

784541
product: 784601
reversible: false
reactant: 784565
reactant: 784553
name: Aldose reductase
reactant: 784577
product: 784613
fast: false
notes: SUBSYSTEM: Glycolysis/Gluconeogeneis
type: Reaction
kinetic law: 784625
product: 784589

850502
value: 0.0
type: LocalParameter

791093
value: 1000.0
type: LocalParameter

832285
value: 1000.0
type: LocalParameter

813927
stoichiometry: 1.0
species: 770333
type: SpeciesReference

843133
stoichiometry: 1.0
species: 768642
type: SpeciesReference

813393
value: 0.0
type: LocalParameter

837576
value: 1000.0
type: LocalParameter

775646
value: 1000.0
type: LocalParameter

820508
stoichiometry: 1.0
species: 766616
type: SpeciesReference

765587
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Ammonium
type: Species

777282
value: 0.0
type: LocalParameter

786836
value: 1000.0
type: LocalParameter

799582
value: 0.0
type: LocalParameter

772564
reactant: 772804
reactant: 772973
reversible: false
reactant: 772744
reactant: 772868
reactant: 772756
reactant: 772588
reactant: 772817
reactant: 772672
reactant: 772600
reactant: 772881
product: 773084
reactant: 772684
reactant: 772636
reactant: 772576
reactant: 772648
reactant: 772780
reactant: 772960
reactant: 772660
reactant: 772920
kinetic law: 773108
reactant: 772829
reactant: 773048
reactant: 772947
reactant: 772933
reactant: 772612
reactant: 772696
reactant: 772624
reactant: 773010
reactant: 772986
reactant: 772720
reactant: 772708
product: 773072
product: 773060
reactant: 772998
reactant: 772732
product: 773096
fast: false
reactant: 772907
reactant: 773035
name: Biomass Demand, Human Adipocyte (biosynthetic GAM)
reactant: 772842
reactant: 772768
reactant: 772894
type: Reaction
reactant: 772792
reactant: 773022
reactant: 772855

839423
value: 0.0
type: LocalParameter

805574
value: 0.0
type: LocalParameter

808501
value: 0.0
type: LocalParameter

778452
value: 1000.0
type: LocalParameter

822623
stoichiometry: 1.0
species: 767537
type: SpeciesReference

776338
value: 0.0
type: LocalParameter

777137
kinetic law: 777173
product: 777161
reactant: 777149
fast: false
reversible: true
name: octadecanoate (n-C18:0) exchange
type: Reaction

827829
value: 1000.0
type: LocalParameter

809272
stoichiometry: 1.0
species: 766616
type: SpeciesReference

818529
stoichiometry: 1.0
species: 766616
type: SpeciesReference

781250
value: 0.0
type: LocalParameter

851179
stoichiometry: 1.0
species: 771816
type: SpeciesReference

807575
stoichiometry: 1.0
species: 768885
type: SpeciesReference

845972
stoichiometry: 0.001
species: 766482
type: SpeciesReference

797938
stoichiometry: 1.0
species: 769863
type: SpeciesReference

850429
stoichiometry: 1.0
species: 767597
type: SpeciesReference

806937
stoichiometry: 1.0
species: 767202
type: SpeciesReference

768763
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: phosphatidylethanolamine, human adipoctye
type: Species

805853
stoichiometry: 1.0
species: 766616
type: SpeciesReference

826348
stoichiometry: 1.0
species: 770622
type: SpeciesReference

856227
value: 0.0
type: LocalParameter

793513
value: 1000.0
type: LocalParameter

825111
value: 0.0
type: LocalParameter

790360
stoichiometry: 1.0
species: 769839
type: SpeciesReference

772418
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: pi_b
type: Species

778950
value: 0.0
type: LocalParameter

836436
value: 1000.0
type: LocalParameter

807235
stoichiometry: 1.0
species: 766398
type: SpeciesReference

767380
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Fructose 2,6-bisphosphate
type: Species

787672
value: 0.0
type: LocalParameter

837840
stoichiometry: 1.0
species: 770574
type: SpeciesReference

774547
stoichiometry: 1.0
species: 771996
type: SpeciesReference

846216
type: Reaction
kinetic law: 846276
reversible: true
notes: GENE_ASSOCIATION: (NM_005415.3 or NM_006749.3) GENE_LIST: NM_005415.3 NM_006749.3 SUBSYSTEM: Transport, Extracellular
product: 846252
reactant: 846228
fast: false
reactant: 846240
product: 846264
name: phosphate transport in/out via proton symporter

781466
value: -1000.0
type: LocalParameter

809488
value: -1000.0
type: LocalParameter

798348
value: -1000.0
type: LocalParameter

828473
value: 1000.0
type: LocalParameter

786206
value: 0.0
type: LocalParameter

796007
stoichiometry: 1.0
species: 766616
type: SpeciesReference

853107
stoichiometry: 1.0
species: 771216
type: SpeciesReference

789595
value: 0.0
type: LocalParameter

799971
stoichiometry: 1.0
species: 766240
type: SpeciesReference

820748
stoichiometry: 0.004
species: 767202
type: SpeciesReference

803542
value: 500.0
type: LocalParameter

775117
stoichiometry: 1.0
species: 765357
type: SpeciesReference

783016
stoichiometry: 1.0
species: 769198
type: SpeciesReference

841838
value: -1000.0
type: LocalParameter

787912
stoichiometry: 1.0
species: 768359
type: SpeciesReference

819903
reactant: 819939
product: 819987
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
reactant: 819927
fast: false
reversible: false
kinetic law: 820023
reactant: 819951
product: 819975
type: Reaction
name: fatty acid synthase (n-C22:0)
product: 820011
reactant: 819915
product: 819999
product: 819963

812252
stoichiometry: 1.0
species: 766604
type: SpeciesReference

810369
value: 1000.0
type: LocalParameter

853940
value: 1000.0
type: LocalParameter

779728
value: -1000.0
type: LocalParameter

854606
stoichiometry: 1.0
species: 766895
type: SpeciesReference

850212
stoichiometry: 1.0
species: 771070
type: SpeciesReference

830986
value: 0.0
type: LocalParameter

822092
stoichiometry: 1.0
species: 767524
type: SpeciesReference

788625
value: 1000.0
type: LocalParameter

766144
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Acetoacetyl-CoA
type: Species

828979
value: 1000.0
type: LocalParameter

840957
value: 0.0
type: LocalParameter

786603
stoichiometry: 4.0
species: 767767
type: SpeciesReference

854790
value: 1000.0
type: LocalParameter

801732
value: -1000.0
type: LocalParameter

840535
value: 0.0
type: LocalParameter

856012
stoichiometry: 1.0
species: 769367
type: SpeciesReference

769983
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: docosapentaenoyl carnitine (C22:5Crn, n-3)
type: Species

815221
stoichiometry: 8.0
species: 770333
type: SpeciesReference

799462
value: 0.0
type: LocalParameter

797078
stoichiometry: 1.0
species: 766628
type: SpeciesReference

842466
type: Reaction
product: 842502
notes: GENE_ASSOCIATION: (NM_000436.2 or NM_022120.1) GENE_LIST: NM_000436.2 NM_022120.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
product: 842515
reversible: true
kinetic law: 842527
reactant: 842478
fast: false
name: 3-oxoacid CoA-transferase
reactant: 842490

807344
value: 0.0
type: LocalParameter

836327
notes: GENE_ASSOCIATION: (NM_000429.2 or (NM_005911.4 and NM_182796.1) or (NM_005911.4 and NM_013283.3)) GENE_LIST: NM_000429.2 NM_005911.4 NM_013283.3 NM_182796.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
reactant: 836351
product: 836375
reactant: 836363
type: Reaction
product: 836400
fast: false
reactant: 836339
reversible: false
name: methionine adenosyltransferase
product: 836387
kinetic law: 836412

844234
value: 1000.0
type: LocalParameter

801624
value: 0.0
type: LocalParameter

774437
stoichiometry: 1.0
species: 765273
type: SpeciesReference

829706
reversible: true
product: 829742
reactant: 829718
product: 829766
type: Reaction
kinetic law: 829778
product: 829754
notes: GENE_ASSOCIATION: (NM_001037811.2 or NM_004493.2) GENE_LIST: NM_001037811.2 NM_004493.2 SUBSYSTEM: Amino Acid Metabolism
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reactant: 829730

787564
product: 787612
product: 787648
name: C-4 methyl sterol oxidase NADH
notes: GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Metabolism
reactant: 787576
reversible: false
reactant: 787600
fast: false
kinetic law: 787660
reactant: 787588
product: 787636
product: 787624
type: Reaction

826457
value: 0.0
type: LocalParameter

824144
value: 1000.0
type: LocalParameter

847557
value: 500.0
type: LocalParameter

831767
value: 0.0
type: LocalParameter

841090
value: 500.0
type: LocalParameter

786543
value: 0.0
type: LocalParameter

823302
value: 500.0
type: LocalParameter

779836
value: -1000.0
type: LocalParameter

799862
value: 0.0
type: LocalParameter

849162
value: 1000.0
type: LocalParameter

829850
stoichiometry: 1.0
species: 766604
type: SpeciesReference

794704
value: -1000.0
type: LocalParameter

771192
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 5,6,7,8-Tetrahydrofolate
type: Species

781575
value: -1000.0
type: LocalParameter

774886
value: 0.0
type: LocalParameter

793403
value: 0.0
type: LocalParameter

814774
stoichiometry: 8.0
species: 769851
type: SpeciesReference

830395
kinetic law: 830431
product: 830419
reactant: 830407
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hexadecenoate (C16:1, n-9) transport
type: Reaction

768873
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Propanoyl-CoA (C3:0CoA)
type: Species

766252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: S-Adenosyl-L-homocysteine
type: Species

780090
stoichiometry: 1.0
species: 768800
type: SpeciesReference

842576
value: 0.0
type: LocalParameter

836824
value: 1000.0
type: LocalParameter

845246
value: 1000.0
type: LocalParameter

785056
value: 0.0
type: LocalParameter

810212
value: -1000.0
type: LocalParameter

777414
value: 500.0
type: LocalParameter

819795
stoichiometry: 1.0
species: 766616
type: SpeciesReference

812143
value: 1000.0
type: LocalParameter

846324
value: 0.0
type: LocalParameter

821472
kinetic law: 821508
product: 821496
reactant: 821484
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: iron (II) transport
type: Reaction

783741
stoichiometry: 1.0
species: 765575
type: SpeciesReference

820857
stoichiometry: 0.005
species: 768446
type: SpeciesReference

835446
stoichiometry: 1.0
species: 769681
type: SpeciesReference

771900
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: co2_b
type: Species

822551
value: 0.0
type: LocalParameter

812833
value: 0.0
type: LocalParameter

775225
stoichiometry: 1.0
species: 772080
type: SpeciesReference

856335
value: 0.0
type: LocalParameter

788516
value: 1000.0
type: LocalParameter

849089
stoichiometry: 1.0
species: 768993
type: SpeciesReference

807465
value: -1000.0
type: LocalParameter

776047
value: 0.0
type: LocalParameter

828775
stoichiometry: 2.0
species: 767743
type: SpeciesReference

843763
stoichiometry: 1.0
species: 768861
type: SpeciesReference

818829
stoichiometry: 1.0
species: 766833
type: SpeciesReference

841402
value: -1000.0
type: LocalParameter

847703
product: 847739
product: 847751
product: 847763
reversible: false
notes: GENE_ASSOCIATION: (NM_004563.2 or NM_001018073.1) GENE_LIST: NM_001018073.1 NM_004563.2 SUBSYSTEM: Pyruvate Metabolism
reactant: 847715
reactant: 847727
name: Phosphoenolpyruvate carboxykinase (GTP), mitochondrial
fast: false
type: Reaction
kinetic law: 847775

790937
stoichiometry: 1.0
species: 769935
type: SpeciesReference

817850
value: 0.0
type: LocalParameter

790793
stoichiometry: 1.0
species: 766968
type: SpeciesReference

800672
stoichiometry: 1.0
species: 766652
type: SpeciesReference

771384
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Desmosterol
type: Species

844907
value: 1000.0
type: LocalParameter

839035
value: 0.0
type: LocalParameter

793887
value: 0.0
type: LocalParameter

850659
value: 0.0
type: LocalParameter

854207
value: 0.0
type: LocalParameter

775538
value: -1000.0
type: LocalParameter

837684
value: 0.0
type: LocalParameter

855006
stoichiometry: 0.001
species: 769258
type: SpeciesReference

778343
value: 0.0
type: LocalParameter

827162
stoichiometry: 1.0
species: 768286
type: SpeciesReference

770985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Phosphate
type: Species

812688
stoichiometry: 1.0
species: 770019
type: SpeciesReference

769839
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: CO2
type: Species

839314
product: 839350
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (NM_003048.3 or NM_001011552.1 or NM_004174.1 or NM_004594.1 or NM_173653.1 or NM_003047.2) GENE_LIST: NM_001011552.1 NM_003047.2 NM_003048.3 NM_004174.1 NM_004594.1 NM_173653.1 SUBSYSTEM: Transport, Extracellular
kinetic law: 839374
product: 839362
reactant: 839326
reactant: 839338
name: sodium transport in/out via proton antiport (one H+), blood

804486
value: 500.0
type: LocalParameter

779401
value: 0.0
type: LocalParameter

768058
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: IMP
type: Species

771046
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Diphosphate
type: Species

770829
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecenoyl carnitine (C18:1Crn, n5)
type: Species

767960
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: heptadecanoate (C17:0)
type: Species

827719
value: 500.0
type: LocalParameter

810598
stoichiometry: 1.0
species: 766338
type: SpeciesReference

801020
stoichiometry: 1.0
species: 766592
type: SpeciesReference

791744
stoichiometry: 1.0
species: 767028
type: SpeciesReference

836702
value: 1000.0
type: LocalParameter

849948
stoichiometry: 1.0
species: 766956
type: SpeciesReference

840038
value: 0.0
type: LocalParameter

848434
value: 0.0
type: LocalParameter

813652
stoichiometry: 1.0
species: 770153
type: SpeciesReference

810091
value: 0.0
type: LocalParameter

830515
stoichiometry: 1.0
species: 767609
type: SpeciesReference

774668
value: 0.0
type: LocalParameter

781793
value: 0.0
type: LocalParameter

782510
stoichiometry: 0.002
species: 767016
type: SpeciesReference

769294
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: tetradecanoate (C14:0)
type: Species

816064
stoichiometry: 1.0
species: 770032
type: SpeciesReference

786762
stoichiometry: 1.0
species: 767779
type: SpeciesReference

841625
value: 0.0
type: LocalParameter

824577
value: 0.0
type: LocalParameter

814121
stoichiometry: 7.0
species: 770333
type: SpeciesReference

835218
value: -1000.0
type: LocalParameter

779618
value: -1000.0
type: LocalParameter

838203
stoichiometry: 1.0
species: 770634
type: SpeciesReference

829632
stoichiometry: 1.0
species: 771732
type: SpeciesReference

802804
stoichiometry: 1.0
species: 768359
type: SpeciesReference

778513
stoichiometry: 1.0
species: 772491
type: SpeciesReference

800237
type: Reaction
reversible: false
reactant: 800249
fast: false
notes: GENE_ASSOCIATION: ((NM_013387.3 and NM_001916.2 and MT4519 and NM_006830.2 and NM_006294.2 and NM_003365.2 and NM_003366.2 and NM_006003.1 and NM_006004.2 and NM_014402.3) or (NM_001003684.1 and NM_001916.2 and MT4519 and NM_006830.2 and NM_006294.2 and NM_003365.2 and NM_003366.2 and NM_006003.1 and NM_006004.2 and NM_014402.3)) GENE_LIST: MT4519 NM_001003684.1 NM_001916.2 NM_003365.2 NM_003366.2 NM_006003.1 NM_006004.2 NM_006294.2 NM_006830.2 NM_013387.3 NM_014402.3 SUBSYSTEM: Oxidative Phosphorylation
reactant: 800261
product: 800309
product: 800297
name: ubiquinol-6 cytochrome c reductase, Complex III
reactant: 800273
product: 800285
kinetic law: 800321

767267
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosenoyl carnitine (C20:1Crn, n-11)
type: Species

802732
value: 1000.0
type: LocalParameter

807126
kinetic law: 807163
product: 807151
reactant: 807139
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ethanol transport in/out via diffusion
type: Reaction

818697
stoichiometry: 1.0
species: 766604
type: SpeciesReference

798602
value: 1000.0
type: LocalParameter

802179
stoichiometry: 1.0
species: 765225
type: SpeciesReference

804050
stoichiometry: 1.0
species: 767767
type: SpeciesReference

805416
value: 1000.0
type: LocalParameter

848006
stoichiometry: 1.0
species: 766034
type: SpeciesReference

819649
stoichiometry: 1.0
species: 768397
type: SpeciesReference

831611
value: -1000.0
type: LocalParameter

775926
value: 0.0
type: LocalParameter