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717379
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kind: MOLE
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596246
constant: true
value: 10.0
name: p13
type: Parameter

596256
constant: true
value: 0.01
name: p21
type: Parameter

596165
constant: false
value: NaN
name: ATPm
type: Parameter

596206
constant: false
value: NaN
name: heav_Cton3
type: Parameter

596175
constant: false
value: NaN
name: delta
type: Parameter

596211
constant: false
value: NaN
name: Juni
type: Parameter

ORG:
  orgname: The University of Auckland
n:
  given: Tessa
  family: Paris

717392
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596195
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717793
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596231
constant: true
value: 5.0E-4
name: kgpdh
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596205
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717854
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596251
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value: 0.002
name: p17
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596185
constant: false
value: NaN
name: Fproto
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717647
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kind: LITRE
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596238
constant: true
value: 177.0
name: p6
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717781
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scale: -3
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kind: SECOND
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717732
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scale: -3
multipler: 1.0
kind: VOLT
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717503
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multipler: 1.0
kind: SECOND
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MODEL1006230114
rule: 596118
parameter: 596246
parameter: 596208
parameter: 596226
rule: 596145
parameter: 596195
rule: 596131
substance units: 178797
rule: 596149
parameter: 596190
rule: 596129
rule: 596103
units def: 717623
rule: 596135
rule: 596126
parameter: 596259
parameter: 596166
parameter: 596241
units def: 717466
parameter: 596159
parameter: 596244
rule: 596139
rule: 596123
parameter: 596182
rule: 596132
rule: 596142
parameter: 596183
units def: 717367
rule: 596127
rule: 596136
parameter: 596169
parameter: 596254
parameter: 596197
parameter: 596213
rule: 596133
time units: 717890
volume units: 290956
rule: 596130
type: SBMLModel
is described by: http://identifiers.org/pubmed/16945388
parameter: 596227
area units: 237671
parameter: 596154
parameter: 596232
parameter: 596175
rule: 596102
parameter: 596212
rule: 596137
parameter: 596253
units def: 717744
parameter: 596196
parameter: 596250
parameter: 596202
rule: 596121
parameter: 596170
rule: 596109
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parameter: 596205
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rule: 596125
rule: 596148
parameter: 596185
rule: 596111
parameter: 596245
parameter: 596235
parameter: 596215
parameter: 596239
parameter: 596200
parameter: 596163
rule: 596115
rule: 596141
notes: This a model from the article: A simplified model for mitochondrial ATP production. Bertram R, Gram Pedersen M, Luciani DS, Sherman A. J Theor Biol 2006 Dec 21;243(4):575-86 16945388 , Abstract: Most of the adenosine triphosphate (ATP) synthesized during glucose metabolism is produced in the mitochondria through oxidative phosphorylation. This is a complex reaction powered by the proton gradient across the mitochondrial inner membrane, which is generated by mitochondrial respiration. A detailed model of this reaction, which includes dynamic equations for the key mitochondrial variables, was developed earlier by Magnus and Keizer. However, this model is extraordinarily complicated. We develop a simpler model that captures the behavior of the original model but is easier to use and to understand. We then use it to investigate the mitochondrial responses to glycolytic and calcium input. We use the model to explain experimental observations of the opposite effects of raising cytosolic Ca(2+)in low and high glucose, and to predict the effects of a mutation in the mitochondrial enzyme nicotinamide nucleotide transhydrogenase (Nnt) in pancreatic beta-cells. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Bertram R, Gram Pedersen M, Luciani DS, Sherman A. (2006) - version=1.0 The original CellML model was created by: Tessa Paris tpar054@aucklanduni.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or em…
parameter: 596187
rule: 596107
parameter: 596234
parameter: 596255
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596219
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value: NaN
name: Jh_res
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717805
unit: 717829
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name: C_per_mol
type: SBMLUnitsDef

596176
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value: 0.1
name: c
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596166
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value: NaN
name: RATm
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596210
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value: NaN
name: heav_Ctoff3
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596257
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value: 1.1
name: p22
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717442
unit: 717454
name: mV
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596224
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value: NaN
name: MM1
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596196
constant: true
value: 270000.0
name: Ctoff3
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596260
constant: true
value: 0.016
name: p24
type: Parameter

W3 CDTF: Fri Jun 25 14:56:38 BST 2010

717575
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name: p16
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596186
constant: false
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name: Cproto
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596239
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name: p7
type: Parameter

596177
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value: 0.5
name: FBP
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596218
constant: false
value: NaN
name: Jo
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596244
constant: true
value: 5.0
name: p11
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596163
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596237
constant: true
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name: p5
type: Parameter

596227
constant: false
value: NaN
name: b13
type: Parameter

596208
constant: false
value: NaN
name: heav_Ctoff2
type: Parameter

W3 CDTF: Fri Jun 25 14:56:38 BST 2010

596228
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value: NaN
name: b2
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717683
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717659
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596197
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name: pulse1
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name: Ftoff
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596164
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name: Amtot
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596190
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name: Cton1
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717405
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596178
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value: NaN
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596245
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596217
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value: NaN
name: Jh_atp
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596226
constant: false
value: NaN
name: MM2
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596259
constant: true
value: 0.001
name: p23
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717744
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name: uM_per_ms_per_mV
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596207
constant: false
value: NaN
name: heav_Ctoff1
type: Parameter

W3 CDTF: Fri Jun 25 14:56:38 BST 2010

717587
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717611
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596198
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value: NaN
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717454
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596170
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name: Ac_tot
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596216
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name: Jh_leak
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596159
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value: 0.1
name: Cam
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596181
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name: Ftest
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596171
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717878
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717539
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717623
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unit: 717647
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717671
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unit: 717696
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596191
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value: 180000.0
name: Cton2
type: Parameter

717491
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name: per_ms
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596158
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596221
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596215
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717756
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717551
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596152
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596235
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value: 0.6
name: p4
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596168
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name: ATPc
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596253
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name: p18
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596172
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596182
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717466
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717599
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596192
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596162
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596157
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596200
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596229
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717841
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596098
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ORG:
  orgname: The University of Auckland
n:
  given: Tessa
  family: Paris

596234
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717866
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596240
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596254
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596193
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name: Ctoff1
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717418
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717479
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596156
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value: NaN
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596154
constant: true
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596223
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717430
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596213
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717903
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596203
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596233
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717367
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717696
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717563
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596248
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717768
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596174
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596255
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596241
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596160
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596212
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value: NaN
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596222
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717515
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596232
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name: p1
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596169
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name: ADPc
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717720
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596202
constant: false
value: NaN
name: heav_off
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596249
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596188
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717817
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kind: COULOMB
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596153
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value: 0.6
name: NADHm
type: Parameter

W3 CDTF: Fri Jun 25 14:56:38 BST 2010

given: Tessa
family: Paris

orgname: The University of Auckland