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MODEL1006230025
rule: 658278
rule: 658270
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 658324
parameter: 658306
modified:
  W3 CDTF: Fri Jun 25 13:34:19 BST 2010
rule: 658272
is described by: http://identifiers.org/pubmed/17440218
parameter: 658284
units def: 324418
area units: 291053
substance units: 178797
parameter: 658318
parameter: 658320
time units: 324623
rule: 658266
units def: 324623
parameter: 658296
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
units def: 324382
parameter: 658298
rule: 658268
rule: 658274
volume units: 290956
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 658302
parameter: 658285
parameter: 658300
rule: 658265
rule: 658276
parameter: 658314
parameter: 658292
modified:
  W3 CDTF: Fri Jun 25 13:34:19 BST 2010
parameter: 658316
rule: 658282
units def: 324503
parameter: 658326
parameter: 658328
parameter: 658310
parameter: 658294
curated: false
units def: 324442
units def: 324599
modified:
  W3 CDTF: Fri Jun 25 13:34:19 BST 2010
rule: 658280
parameter: 658288
units def: 324551
created:
  W3 CDTF: Fri Jun 25 13:34:19 BST 2010
compartment: 658261
parameter: 658304
name: Phillips2007_AscendingArousalSystem_SleepWakeDynamics
units def: 324358
length unit: 455845
parameter: 658322
units def: 324466
parameter: 658308
parameter: 658312
notes: This a model from the article: A quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system. Phillips AJ, Robinson PA. J Biol Rhythms 2007 Apr;22(2):167-79 17440218 , Abstract: A quantitative, physiology-based model of the ascending arousal system is developed, using continuum neuronal population modeling, which involves averaging properties such as firing rates across neurons in each population. The model includes the ventrolateral preoptic area (VLPO), where circadian and homeostatic drives enter the system, the monoaminergic and cholinergic nuclei of the ascending arousal system, and their interconnections. The human sleep-wake cycle is governed by the activities of these nuclei, which modulate the behavioral state of the brain via diffuse neuromodulatory projections. The model parameters are not free since they correspond to physiological observables. Approximate parameter bounds are obtained by requiring consistency with physiological and behavioral measures, and the model replicates the human sleep-wake cycle, with physiologically reasonable voltages and firing rates. Mutual inhibition between the wake-promoting monoaminergic group and sleep-promoting VLPO causes ;;flip-flop'' behavior, with most time spent in 2 stable steady states corresponding to wake and sleep, with transitions between them on a timescale of a few minutes. The model predicts hysteresis in the sleep-wake cycle, with a region of bistability of the wake and sleep states. Reducing the monoaminergic-VLPO mutual inhibition results in a smaller hysteresis loop. This makes the model more prone to wake-sleep transitions in both directions and makes the states less distinguishable, as in narcolepsy. The model behavior is robust across the constrained parameter ranges, but with sufficient flexibility to describe a wide range of observed phenomena. This model was taken from the CellML repository and automatically converted to SBML. The original model wa…
parameter: 658330
parameter: 658290
type: SBMLModel

658300
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value: 0.0
name: Vm
type: Parameter

658316
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value: NaN
name: C
type: Parameter

324551
unit: 324587
unit: 324575
unit: 324563
name: mV_per_nM
type: SBMLUnitsDef

658310
constant: true
value: 10.8
name: chi
type: Parameter

324503
unit: 324539
unit: 324527
unit: 324515
name: nM_second
type: SBMLUnitsDef

658314
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value: NaN
name: D
type: Parameter

324539
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658324
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value: 0.19
name: v_vh
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324575
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324382
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unit: 324394
name: mV_second
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324406
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658320
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value: NaN
name: omega
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658306
constant: true
value: 1.0
name: v_maQao
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324442
unit: 324454
name: per_hour
type: SBMLUnitsDef

324466
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unit: 324479
name: nM
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324611
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658296
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value: 1.0
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324599
unit: 324611
name: per_second
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658292
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value: NaN
name: Qa
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658330
constant: true
value: 3.0
name: sigma
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658285
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value: 0.0
name: Vv
type: Parameter

658288
constant: true
value: 10.0
name: tau_v
type: Parameter

658318
constant: true
value: 1.0
name: c0
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658302
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value: 10.0
name: tau_m
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324515
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kind: MOLE
type: SBMLUnit

658298
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value: NaN
name: Qm
type: Parameter

658312
constant: true
value: 3.6
name: mu
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324370
exponent: 1.0
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kind: VOLT
type: SBMLUnit

324358
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name: mV
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658328
constant: true
value: 10.0
name: theta
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658304
constant: true
value: -1.9
name: v_mv
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658326
constant: true
value: 100.0
name: Qmax
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658308
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value: 15.0
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324430
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324479
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324527
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324491
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324563
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324394
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658284
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value: NaN
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658322
constant: true
value: -6.3
name: v_vc
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324418
unit: 324430
name: hour
type: SBMLUnitsDef

658294
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324587
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324454
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multipler: 3600.0
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324623
unit: 324636
name: time
type: SBMLUnitsDef

658290
constant: true
value: -1.9
name: v_vm
type: Parameter

658261
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment