994834
constant: true
value: 98.0
name: k_5
type: Parameter

994817
constant: false
value: 0.0
name: NO
type: Parameter

224047
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

994842
constant: true
value: 1.89
name: k_9
type: Parameter

994803
constant: false
value: NaN
name: S
type: Parameter

994813
constant: false
value: 0.0
name: Fe3_O2_NOHA
type: Parameter

994772
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

994822
constant: false
value: 0.0
name: NOHA
type: Parameter

994823
constant: true
value: 172.0
name: O2
type: Parameter

224072
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

994807
constant: false
value: 0.0
name: Fe2_Arg
type: Parameter

994827
constant: true
value: 0.91
name: k2
type: Parameter

994833
constant: true
value: 2.58
name: k5
type: Parameter

994837
constant: true
value: 0.91
name: k7
type: Parameter

994818
constant: false
value: NaN
name: dNOdt
type: Parameter

223987
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

994843
constant: true
value: 3.33
name: k10
type: Parameter

994847
constant: true
value: 0.91
name: k12
type: Parameter

224096
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

994804
constant: false
value: 0.045
name: Fe3
type: Parameter

994814
constant: false
value: 0.0
name: Fe3_NO
type: Parameter

224011
unit: 224023
name: first_order_rate_constant
type: SBMLUnitsDef

224120
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

MODEL1006230005
substance units: 178797
parameter: 994845
parameter: 994822
is described by: http://identifiers.org/pubmed/16864000
length unit: 335510
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
volume units: 950046
rule: 994796
rule: 994782
parameter: 994818
parameter: 994805
parameter: 994803
parameter: 994821
parameter: 994831
parameter: 994819
notes: This a model from the article: Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells. Chen K, Popel AS. Free Radic Biol Med 2006 Aug 15;41(4):668-80 16864000 , Abstract: Vascular endothelium expressing endothelial nitric oxide synthase (eNOS) produces nitric oxide (NO), which has a number of important physiological functions in the microvasculature. The rate of NO production by the endothelium is a critical determinant of NO distribution in the vascular wall. We have analyzed the biochemical pathways of NO synthesis and formulated a model to estimate NO production by the microvascular endothelium under physiological conditions. The model quantifies the NO produced by eNOS based on the kinetics of NO synthesis and the availability of eNOS and its intracellular substrates. The predicted NO production from microvessels was in the range of 0.005-0.1 microM/s. This range of predicted values is in agreement with some experimental values but is much lower than other rates previously measured or estimated from experimental data with the help of mathematical modeling. Paradoxical discrepancies between the model predictions and previously reported results based on experimental measurements of NO concentration in the vicinity of the arteriolar wall suggest that NO can also be released through eNOS-independent mechanisms, such as catalysis by neuronal NOS (nNOS). We also used our model to test the sensitivity of NO production to substrate availability, eNOS concentration, and potential rate-limiting factors. The results indicated that the predicted low level of NO production can be attributed primarily to a low expression of eNOS in the microvascular endothelial cells. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Chen K, Popel AS. (2006) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model …
rule: 994780
parameter: 994837
parameter: 994847
curated: false
parameter: 994850
rule: 994797
parameter: 994814
units def: 224011
rule: 994785
rule: 994794
parameter: 994846
parameter: 994829
parameter: 994839
rule: 994788
area units: area
parameter: 994810
time units: 219790
parameter: 994842
created:
  W3 CDTF: Fri Jun 25 13:06:36 BST 2010
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
type: SBMLModel
parameter: 994806
parameter: 994804
units def: 223975
rule: 994777
modified:
  W3 CDTF: Fri Jun 25 13:06:36 BST 2010
parameter: 994807
rule: 994792
parameter: 994825
parameter: 994835
parameter: 994851
modified:
  W3 CDTF: Fri Jun 25 13:06:36 BST 2010
rule: 994786
name: Chen2006_NitricOxideRelease
rule: 994793
parameter: 994802
rule: 994800
rule: 994781
parameter: 994834
parameter: 994811
parameter: 994817
parameter: 994827
compartment: 994772
parameter: 994833
parameter: 994815
parameter: 994843
rule: 994784
parameter: 994809
units def: 224084
parameter: 994830
modified:
  W3 CDTF: Fri Jun 25 13:06:36 BST 2010
rule: 994790
parameter: 994838
rule: 994789
parameter: 994826
rule: 994798
parameter: 994823
parameter: 994813
parameter: 994841
units def: 224035
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd

994838
constant: true
value: 0.1
name: k8
type: Parameter

994815
constant: false
value: 0.0
name: Fe2_NO
type: Parameter

994850
constant: true
value: 0.033
name: k13
type: Parameter

224035
unit: 224072
unit: 224060
unit: 224047
name: second_order_rate_constant
type: SBMLUnitsDef

994805
constant: false
value: 0.0
name: Fe3_Arg
type: Parameter

994839
constant: true
value: 0.1
name: k_8
type: Parameter

994810
constant: false
value: 0.0
name: Fe3_NOHA
type: Parameter

994825
constant: true
value: 0.1
name: k1
type: Parameter

994821
constant: false
value: 0.0
name: NO3
type: Parameter

994831
constant: true
value: 11.4
name: k_4
type: Parameter

994835
constant: true
value: 12.6
name: k6
type: Parameter

994829
constant: true
value: 0.91
name: k3
type: Parameter

994845
constant: true
value: 89.9
name: k_10
type: Parameter

994819
constant: false
value: 0.0
name: citrulline
type: Parameter

994809
constant: false
value: 0.0
name: Fe3_O2_Arg
type: Parameter

224060
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

223975
unit: 223999
unit: 223987
name: micromolar
type: SBMLUnitsDef

994802
constant: false
value: 100.0
name: Arg
type: Parameter

994851
constant: true
value: 53.9
name: k14
type: Parameter

223999
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

994806
constant: false
value: 0.0
name: Fe2
type: Parameter

224108
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

224084
unit: 224120
unit: 224108
unit: 224096
name: flux
type: SBMLUnitsDef

994841
constant: true
value: 11.4
name: k9
type: Parameter

994826
constant: true
value: 0.1
name: k_1
type: Parameter

994811
constant: false
value: 0.0
name: Fe2_NOHA
type: Parameter

224023
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

994846
constant: true
value: 29.4
name: k11
type: Parameter

994830
constant: true
value: 1.89
name: k4
type: Parameter