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257892
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value: 0.0
name: D
type: Parameter

257905
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units: 530275
value: 0.1
name: ke
type: Parameter

257894
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units: 530167
value: 0.0
name: R
type: Parameter

530287
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scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

257909
constant: true
units: 530275
value: 0.05
name: kdeg
type: Parameter

257907
constant: true
units: 530275
value: 0.0
name: krec
type: Parameter

257912
constant: true
units: dimensionless
value: 0.2
name: kappaE
type: Parameter

257910
constant: true
units: 530227
value: 10.0
name: Vs
type: Parameter

530299
unit: 530335
unit: 530323
unit: 530311
name: second_order_rate_constant
type: SBMLUnitsDef

257900
constant: false
units: 530275
value: NaN
name: kr1
type: Parameter

530335
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scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

530347
unit: 530359
name: time
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530203
unit: 530215
name: minute
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MODEL0848676877
units def: 530275
rule: 257887
curated: false
parameter: 257899
rule: 257889
parameter: 257912
parameter: 257907
units def: 530203
units def: 530299
parameter: 257904
parameter: 257910
type: SBMLModel
parameter: 257901
notes: This a model from the article: Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonists. Haugh JM. Biotechnol Prog 2004 Sep-Oct;20(5):1337-44 15458315 , Abstract: Human growth hormone (hGH) is a therapeutically important endocrine factor that signals various cell types. Structurally and functionally, the interactions of hGH with its receptor have been resolved in fine detail, such that hGH and hGH receptor variants can be practically engineered by either random or rational approaches to achieve significant changes in the free energies of binding. A somewhat unique feature of hGH action is its homodimerization of two hGH receptors, which is required for intracellular signaling and stimulation of cell proliferation, yet the potencies of hGH mutants in cell-based assays rarely correlate with their overall receptor-binding avidities. Here, a mathematical model of hGH-stimulated cell signaling is posed, accounting not only for binding interactions at the cell surface but induction of receptor endocytosis and downregulation as well. Receptor internalization affects ligand potency by imposing a limit on the lifetime of an active receptor complex, irrespective of ligand-receptor binding properties. The model thus explains, in quantitative terms, the numerous published observations regarding hGH receptor agonism and antagonism and challenges the interpretations of previous studies that have not considered receptor trafficking as a central regulatory mechanism in hGH signaling. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Haugh JM. (2004) - version02 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is co…
parameter: 257891
volume units: volume
area units: area
rule: 257888
parameter: 257911
parameter: 257906
parameter: 257902
parameter: 257895
units def: 530347
parameter: 257896
parameter: 257892
substance units: 469466
length unit: 027038
parameter: 257900
units def: 530227
units def: 530167
rule: 257885
parameter: 257897
parameter: 257905
time units: 530347
parameter: 257894
name: Haugh2004_hGH
rule: 257880
is described by: http://identifiers.org/pubmed/15458315
rule: 257882
rule: 257883
compartment: 257876
parameter: 257914
rule: 257884
parameter: 257909

530167
unit: 530191
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name: nanomolar
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530311
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257895
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units: 530167
value: 0.0
name: Ri
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257904
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units: 530275
value: NaN
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257897
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units: dimensionless
value: NaN
name: signal
type: Parameter

257906
constant: true
units: 530275
value: 0.005
name: kt
type: Parameter

530215
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multipler: 60.0
kind: SECOND
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530251
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530191
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257891
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name: C
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257911
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value: 0.01
name: L
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257902
constant: true
units: 530275
value: 0.016
name: k_x2
type: Parameter

530323
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scale: 0
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kind: LITRE
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257899
constant: true
units: 530299
value: 0.1
name: kf1
type: Parameter

257914
constant: true
units: 530167
value: 1.0
name: KD
type: Parameter

530263
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multipler: 60.0
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530227
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unit: 530239
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257901
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value: 4.83
name: kx2
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257896
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value: NaN
name: R0
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530275
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name: first_order_rate_constant
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257876
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

530239
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kind: MOLE
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