par38
constant: true
value: 12.0
name: cl_lh
type: Parameter

CDMT00067
stoichiometry: 1.0
species: s39
type: SpeciesReference

par24
constant: true
value: 0.152
name: T_p4_fsh
type: Parameter

COPASI7
constant: false
value: 3.62064120302475E-4
name: Total_PGF_2alpha
type: Parameter

CDMT00050
stoichiometry: 1.0
species: s34
type: SpeciesReference

CDMT00040
stoichiometry: 1.0
species: s29
type: SpeciesReference

CDMT00015
stoichiometry: 1.0
species: s17
type: SpeciesReference

par3
constant: true
value: 2.05
name: h_P4&E2_G
type: Parameter

re11
reactant: CDMT00027
type: Reaction
product: CDMT00028
modifier: CDMT00115
reversible: false
modifier: CDMT00116
name: re11
fast: false

re17
product: CDMT00040
reactant: CDMT00039
fast: false
reversible: false
name: re17
type: Reaction

par10
constant: true
value: 1.63
name: cl_G
type: Parameter

par65
constant: true
value: 41.39
name: h_iof_cl
type: Parameter

s30
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_OT
type: Species

s20
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_Inh
type: Species

re27
fast: false
modifier: CDMT00107
type: Reaction
reversible: false
product: CDMT00073
reactant: CDMT00072
modifier: CDMT00106
name: re27

CDMT00025
stoichiometry: 1.0
species: s22
type: SpeciesReference

CDMT00026
stoichiometry: 1.0
species: s14
type: SpeciesReference

volume
unit: CDMT00057
name: volume
type: SBMLUnitsDef

COPASI6
constant: true
value: 0.0
name: t_D
type: Parameter

CDMT00068
stoichiometry: 1.0
species: s2
type: SpeciesReference

par25
constant: true
value: 0.396
name: h_e2_fsh
type: Parameter

re12
product: CDMT00030
reactant: CDMT00029
fast: false
reversible: false
name: re12
type: Reaction

par4
constant: true
value: 0.0972
name: T_E2_G1
type: Parameter

CDMT00016
stoichiometry: 1.0
species: s5
type: SpeciesReference

par64
constant: true
value: 0.1
name: T_cl_cl
type: Parameter

s31
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_Enz
type: Species

re18
product: CDMT00042
reactant: CDMT00041
fast: false
reversible: false
name: re18
type: Reaction

s21
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_OT
type: Species

re28
reactant: CDMT00075
type: Reaction
modifier: CDMT00082
fast: false
product: CDMT00076
name: re28
reversible: false
modifier: CDMT00120

par36
constant: true
value: 0.69
name: T_gnrh_lh
type: Parameter

COPASI5
constant: false
value: 150.0
name: t_mod
type: Parameter

CDMT00052
stoichiometry: 1.0
species: s35
type: SpeciesReference

CDMT00027
stoichiometry: 1.0
species: s23
type: SpeciesReference

re13
product: CDMT00032
reactant: CDMT00031
fast: false
reversible: false
name: re13
type: Reaction

par26
constant: true
value: 0.312
name: T_e2_fsh
type: Parameter

s32
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_PGF
type: Species

re15
product: CDMT00036
reactant: CDMT00035
fast: false
reversible: false
name: re15
type: Reaction

CDMT00013
stoichiometry: 1.0
species: s42
type: SpeciesReference

par77
constant: true
value: 1.23
name: cl_e2
type: Parameter

CDMT00051
stoichiometry: 1.0
species: s9
type: SpeciesReference

COPASI4
constant: true
value: 5.5
name: c_PGF_syn
type: Parameter

par37
constant: true
value: 0.0141
name: b_lh
type: Parameter

s9
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.314393628471893
in compartment: default
name: CL
type: Species

CDMT00028
stoichiometry: 1.0
species: s15
type: SpeciesReference

re1
product: CDMT00008
reactant: CDMT00007
type: Reaction
fast: false
reversible: false
name: re1
modifier: CDMT00061

GnRH max
constant: true
value: 16.0
name: GnRH_max
type: Parameter

par27
constant: true
value: 1.23
name: h_gnrh_fsh
type: Parameter

BIOMD0000000481
parameter: par6
parameter: par33
reaction: re12
species: s30
initial assignment: BIOMD0000000481#
name: Function for re1
parameter: par45
substance units: substance
species: s29
species: s40
reaction: re6
reaction: re15
name: Function for re26
parameter: COPASI4
reaction: re24
species: s25
name: Function for re27
parameter: par94
parameter: par77
species: s21
parameter: par26
parameter: par21
species: s8
parameter: par62
species: s42
name: Function for re4
reaction: re9
parameter: par58
parameter: par48
parameter: COPASI7
species: s4
species: s27
name: Function for re13
parameter: par92
parameter: par96
species: s37
parameter: par82
is derived from: http://identifiers.org/pubmed/22118087
species: s3
name: Function for re9
parameter: par29
species: s23
reaction: re13
parameter: par65
parameter: par30
species: s33
reaction: re27
parameter: par46
is derived from: http://identifiers.org/pubmed/21377476
species: s19
is described by: http://identifiers.org/pubmed/22980082
reaction: re1
name: Function for re21
parameter: par7
units def: length
time units: time
species: s6
parameter: par10
parameter: par95
parameter: par98
reaction: re7
species: s39
parameter: par38
species: s14
parameter: par28
name: Function for re16
parameter: par64
reaction: re25
name: Function for re11
species: s35
parameter: par22
reaction: re19
species: s10
name: Function for re7
reaction: re5
parameter: par9
reaction: re11
parameter: par59
species: s31
area units: area

par66
constant: true
value: 1.32
name: T_iof_cl
type: Parameter

s33
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_IOF
type: Species

CDMT00014
stoichiometry: 1.0
species: s9
type: SpeciesReference

re16
product: CDMT00038
reactant: CDMT00037
fast: false
reversible: false
name: re16
type: Reaction

re14
product: CDMT00034
reactant: CDMT00033
fast: false
reversible: false
name: re14
type: Reaction

s8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0286570978235457
in compartment: default
name: Foll
type: Species

par76
constant: true
value: 2.19
name: k_foll_e2
type: Parameter

CDMT00019
stoichiometry: 1.0
species: s19
type: SpeciesReference

par34
constant: true
value: 0.0269
name: T_p4_lh
type: Parameter

par41
constant: true
value: 0.562
name: h_fsh_foll
type: Parameter

CDMT00029
stoichiometry: 1.0
species: s2
type: SpeciesReference

CDMT00049
stoichiometry: 1.0
species: s8
type: SpeciesReference

par95
constant: true
value: 39.68
name: h_pg_iof
type: Parameter

s7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0168604631992291
in compartment: default
name: FSH_Bld
type: Species

CDMT00008
stoichiometry: 1.0
species: s4
type: SpeciesReference

par7
constant: true
value: 0.252
name: T_p4_G2
type: Parameter

CDMT00039
stoichiometry: 1.0
species: s12
type: SpeciesReference

par35
constant: true
value: 2.22
name: h_gnrh_lh
type: Parameter

par21
constant: true
value: 4.21
name: h_inh_fsh
type: Parameter

CDMT00007
stoichiometry: 1.0
species: s3
type: SpeciesReference

par94
constant: true
value: 0.644
name: cl_ot
type: Parameter

s6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.00579108659591004
in compartment: default
name: FSH_Pit
type: Species

par8
constant: true
value: 0.99
name: h_e2_g2
type: Parameter

par43
constant: true
value: 0.22
name: T_foll_fsh
type: Parameter

CDMT00017
stoichiometry: 1.0
species: s18
type: SpeciesReference

par5
constant: true
value: 0.35
name: T_p4_G1
type: Parameter

par32
constant: true
value: 0.243
name: T_e2_lh
type: Parameter

par22
constant: true
value: 0.118
name: T_inh_fsh
type: Parameter

CDMT00069
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

par92
constant: true
value: 0.143
name: T_e2_ot
type: Parameter

s5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.740638780629751
in compartment: default
name: GnRH_Hyp
type: Species

CDMT00006
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

CDMT00037
stoichiometry: 1.0
species: s10
type: SpeciesReference

s19
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_P4
type: Species

re19
product: CDMT00044
reactant: CDMT00043
fast: false
reversible: false
name: re19
type: Reaction

par63
constant: true
value: 0.0353
name: h_cl_cl
type: Parameter

CDMT00018
stoichiometry: 1.0
species: s10
type: SpeciesReference

par6
constant: true
value: 1.91
name: h_p4_G2
type: Parameter

re10
modifier: CDMT00088
product: CDMT00026
reactant: CDMT00025
fast: false
reversible: false
name: re10
type: Reaction

par42
constant: true
value: 0.57
name: T_fsh_foll
type: Parameter

par33
constant: true
value: 2.71
name: h_p4_lh
type: Parameter

COPASI8
constant: true
value: 0.0
name: quantity_1
type: Parameter

par23
constant: true
value: 0.293
name: h_p4_fsh
type: Parameter

par91
constant: true
value: 1.59
name: h_e2cl_ot
type: Parameter

par71
constant: true
value: 2.25
name: k_cl_p4
type: Parameter

s4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.00633682772990623
in compartment: default
name: LH_Bld
type: Species

par72
constant: true
value: 1.41
name: cl_p4
type: Parameter

s18
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_E2
type: Species

CDMT00038
stoichiometry: 1.0
species: s28
type: SpeciesReference

par62
constant: true
value: 0.2
name: SF_CL
type: Parameter

s28
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_E2
type: Species

CDMT00048
stoichiometry: 1.0
species: s33
type: SpeciesReference

s41
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_IOF
type: Species

par96
constant: true
value: 1.22
name: T_pg_ot
type: Parameter

CDMT00020
stoichiometry: 1.0
species: s11
type: SpeciesReference

CDMT00030
stoichiometry: 1.0
species: s24
type: SpeciesReference

s38
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_GnRH_Hyp
type: Species

par86
constant: true
value: 3.58
name: h_p4_enz
type: Parameter

CDMT00058
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

par81
constant: true
value: 1.41
name: k_foll_inh
type: Parameter

re22
reactant: CDMT00049
type: Reaction
modifier: CDMT00104
modifier: CDMT00071
reversible: false
product: CDMT00050
fast: false
name: l

par30
constant: true
value: 0.948
name: b_fsh
type: Parameter

par45
constant: true
value: 1.1
name: h_p4_fsh_2
type: Parameter

re7
modifier: CDMT00084
product: CDMT00020
reactant: CDMT00019
fast: false
reversible: false
name: re7
type: Reaction

s10
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.163690728507925
in compartment: default
name: E2
type: Species

par59
constant: true
value: 1.23
name: cl_pgf
type: Parameter

par97
constant: true
value: 0.6
name: T_cl_iof
type: Parameter

s29
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_Inh
type: Species

s40
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_Foll
type: Species

par9
constant: true
value: 0.648
name: T_e2_g2
type: Parameter

par87
constant: true
value: 0.77
name: T_p4_enz
type: Parameter

s39
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_GnRH_Pit
type: Species

CDMT00057
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

re6
modifier: CDMT00083
product: CDMT00018
reactant: CDMT00017
fast: false
reversible: false
name: re6
type: Reaction

length
unit: CDMT00069
name: length
type: SBMLUnitsDef

CDMT00070
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

par82
constant: true
value: 0.475
name: cl_inh
type: Parameter

re21
product: CDMT00048
reactant: CDMT00047
fast: false
reversible: false
name: re21
type: Reaction

par58
constant: true
value: 1.087
name: T_ot_pgf
type: Parameter

CDMT00047
stoichiometry: 1.0
species: s16
type: SpeciesReference

s11
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.120192549532403
in compartment: default
name: P4
type: Species

par31
constant: true
value: 0.376
name: h_e2_lh
type: Parameter

par98
constant: true
value: 0.298
name: cl_iof
type: Parameter

s2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.219992404098564
in compartment: default
name: GnRH_Pit
type: Species

s26
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_FSH
type: Species

CDMT00032
stoichiometry: 1.0
species: s25
type: SpeciesReference

s12
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.493710210684922
in compartment: default
name: Inh
type: Species

W3 CDTF: Mon Sep 23 11:44:31 BST 2013

par57
constant: true
value: 1.43
name: T_enz_pgf
type: Parameter

par47
constant: true
value: 3.49
name: h_lh_foll
type: Parameter

re20
product: CDMT00046
reactant: CDMT00045
fast: false
reversible: false
name: re20
type: Reaction

CDMT00046
stoichiometry: 1.0
species: s32
type: SpeciesReference

re9
modifier: CDMT00123
product: CDMT00024
reversible: false
type: Reaction
fast: false
name: re9
reactant: CDMT00023
modifier: CDMT00122

time
unit: CDMT00070
name: time
type: SBMLUnitsDef

s3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 2.25000957482152
in compartment: default
name: LH_Pit
type: Species

s27
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_P4
type: Species

c G1
constant: true
value: 2.75
name: k_G
type: Parameter

CDMT00009
stoichiometry: 1.0
species: s6
type: SpeciesReference

CDMT00031
stoichiometry: 1.0
species: s4
type: SpeciesReference

CDMT00072
stoichiometry: 1.0
species: s40
type: SpeciesReference

par56
constant: true
value: 53.91
name: h_enz_pgf
type: Parameter

s13
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.111730059223483
in compartment: default
name: OT
type: Species

re8
modifier: CDMT00085
product: CDMT00022
reactant: CDMT00021
fast: false
reversible: false
name: re8
type: Reaction

CDMT00045
stoichiometry: 1.0
species: s15
type: SpeciesReference

par46
constant: true
value: 0.126
name: T_p4_foll
type: Parameter

s34
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_Foll
type: Species

CDMT00034
stoichiometry: 1.0
species: s26
type: SpeciesReference

default
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: default
type: Compartment

s24
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_GnRH_Pit
type: Species

CDMT00024
stoichiometry: 1.0
species: s13
type: SpeciesReference

re26
modifier: CDMT00005
reactant: CDMT00067
reversible: false
fast: false
modifier: CDMT00004
name: re26
product: CDMT00068
type: Reaction
modifier: CDMT00096

par29
constant: true
value: 2.73
name: cl_fsh
type: Parameter

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

CDMT00073
stoichiometry: 1.0
species: s8
type: SpeciesReference

CDMT00044
stoichiometry: 1.0
species: s31
type: SpeciesReference

re3
modifier: CDMT00003
reversible: false
type: Reaction
reactant: CDMT00011
modifier: CDMT00002
product: CDMT00012
name: re3
fast: false

CDMT00011
stoichiometry: 1.0
species: s5
type: SpeciesReference

s14
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 5.83626691122778E-5
in compartment: default
name: Enz
type: Species

COPASI3
constant: true
value: 100.0
name: beta
type: Parameter

CDMT00054
stoichiometry: 1.0
species: s3
type: SpeciesReference

CDMT00033
stoichiometry: 1.0
species: s7
type: SpeciesReference

s35
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_CL
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000481#_4cb72cd7_ca1c_4b18_95fd_f0ecdae2ef6e
constant: true
value: 100.0
name: Initial for beta
type: Parameter

s25
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: snk_LH
type: Species

re25
modifier: CDMT00060
product: CDMT00056
reactant: CDMT00055
fast: false
reversible: false
name: re25
type: Reaction

CDMT00023
stoichiometry: 1.0
species: s21
type: SpeciesReference

CDMT00043
stoichiometry: 1.0
species: s14
type: SpeciesReference

par28
constant: true
value: 0.0708
name: T_gnrh_fsh
type: Parameter

par48
constant: true
value: 0.171
name: T_lh_Foll
type: Parameter

s15
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 3.62064120302475E-4
in compartment: default
name: PGF
type: Species

CDMT00012
stoichiometry: 1.0
species: s38
type: SpeciesReference

COPASI2
constant: true
value: 3.7
name: D
type: Parameter

re2
reactant: CDMT00009
reversible: false
modifier: CDMT00064
name: re2
type: Reaction
product: CDMT00010
modifier: CDMT00063
fast: false
modifier: CDMT00062

CDMT00053
stoichiometry: 1.0
species: s36
type: SpeciesReference

s36
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_LH
type: Species

CDMT00036
stoichiometry: 1.0
species: s27
type: SpeciesReference

s22
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_Enz
type: Species

CDMT00022
stoichiometry: 1.0
species: s12
type: SpeciesReference

substance
unit: CDMT00006
name: substance
type: SBMLUnitsDef

CDMT00075
stoichiometry: 1.0
species: s41
type: SpeciesReference

re24
product: CDMT00054
modifier: CDMT00065
type: Reaction
reactant: CDMT00053
name: re24
modifier: CDMT00066
reversible: false
fast: false

CDMT00042
stoichiometry: 1.0
species: s30
type: SpeciesReference

s16
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.133415086647186
in compartment: default
name: IOF
type: Species

COPASI1
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: default
name: PGF_syn
type: Species

CDMT00056
stoichiometry: 1.0
species: s6
type: SpeciesReference

re5
modifier: CDMT00059
product: CDMT00016
reactant: CDMT00015
fast: false
reversible: false
name: re5
type: Reaction

area
unit: CDMT00058
name: area
type: SBMLUnitsDef

CDMT00035
stoichiometry: 1.0
species: s11
type: SpeciesReference

par89
constant: true
value: 2.98
name: cl_enz
type: Parameter

s37
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_FSH
type: Species

s23
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_PGF
type: Species

CDMT00021
stoichiometry: 1.0
species: s20
type: SpeciesReference

W3 CDTF: Mon Sep 23 11:55:03 BST 2013

s42
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_CL
type: Species

CDMT00076
stoichiometry: 1.0
species: s16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000481#_0c559bf4_0fb2_44b0_98f1_6d6a47d7c535
constant: true
value: 3.7
name: Initial for D
type: Parameter

CDMT00041
stoichiometry: 1.0
species: s13
type: SpeciesReference

re23
name: re23
reactant: CDMT00051
reversible: false
product: CDMT00052
fast: false
modifier: CDMT00089
type: Reaction

CDMT00010
stoichiometry: 1.0
species: s7
type: SpeciesReference

s17
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: src_GnRH
type: Species

CDMT00055
stoichiometry: 1.0
species: s37
type: SpeciesReference

re4
fast: false
type: Reaction
modifier: CDMT00109
modifier: CDMT00110
reactant: CDMT00013
modifier: CDMT00113
name: re4
product: CDMT00014
reversible: false

given: Claudia
family: Stötzel

ORG:
  orgname: Zuse Institute Berlin