CDMT00085
stoichiometry: 1.0
species: s28
type: SpeciesReference

Km11
units: substance
value: 48000.0
type: LocalParameter

CDMT00068
stoichiometry: 1.0
species: s22
type: SpeciesReference

CDMT00121
stoichiometry: 1.0
species: s21
type: SpeciesReference

s18
substance units: substance
is version of: P60484
constant: false
initial amount: 0.1
initial concentration: NaN
name: PTEN
type: Species
has only substance units: true
in compartment: c1
boundary condition: false

CDMT00116
stoichiometry: 1.0
species: s25
type: SpeciesReference

CDMT00078
stoichiometry: 1.0
species: s19
type: SpeciesReference

s28
has part: http://identifiers.org/pubchem.compound/53480352
substance units: substance
constant: false
type: Species
name: AKT:PI3P
in compartment: c1
has only substance units: true
initial concentration: NaN
boundary condition: false
has part: P31749
initial amount: 29.203

re17
fast: false
product: CDMT00091
kinetic law: CDMT00093
modifier: CDMT00092
reactant: CDMT00085
type: Reaction
reversible: false

k4
units: inv subsec
value: 0.045
type: LocalParameter

CDMT00091
stoichiometry: 1.0
species: s26
type: SpeciesReference

BIOMD0000000465
units def: inv subsec
reaction: re1
units def: volume
compartment: c1
species: s24
reaction: re15
species: s25
volume units: volume
reaction: re2
substance units: substance
units def: nM inv s
species: s19
reaction: re18
type: SBMLModel
units def: inv sec
reaction: re21
is version of: GO:0034405
occurs in: http://identifiers.org/taxonomy/9606
species: s28
length unit: length
species: s14
units def: time
creator:
  ORG:
    orgname: Massachusetts Institute of Technology
  n:
    given: Andrew
    family: Koo
reaction: re16
units def: sub sec
species: s22
reaction: re13
species: s23
reaction: re19
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Nick
    family: Juty
is: MODEL1302180004
time units: time
species: s17
species: s18
is version of: REACT 12443.3
name: Koo2013 - Shear stress induced AKT and eNOS phosphorylation - Model 2
is described by: http://identifiers.org/pubmed/23708369
units def: area
reaction: re22
units def: substance
area units: area
species: s27
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
species: s26
compartment: default
reaction: re14
reaction: re20
units def: inv nM s
species: s20
species: s21
reaction: re17
modified:
  W3 CDTF: Thu Oct 10 15:28:05 BST 2013
created:
  W3 CDTF: Mon Aug 19 14:35:11 BST 2013
is version of: GO:0006809
species: s119
units def: length
curated: true
species: s15
species: s16

unitime
units: sub sec
value: 1.0
type: LocalParameter

s17
type: Species
has only substance units: true
is version of: http://identifiers.org/pubchem.compound/53480352
initial amount: 0.345
boundary condition: false
initial concentration: NaN
name: PI3P
substance units: substance
constant: false
in compartment: c1

Km10
units: substance
value: 80000.0
type: LocalParameter

CDMT00120
stoichiometry: 1.0
species: s25
type: SpeciesReference

CDMT00117
stoichiometry: 1.0
species: s14
type: SpeciesReference

s27
has part: P31749
boundary condition: false
has part: http://identifiers.org/pubchem.compound/53480352
substance units: substance
constant: false
type: Species
in compartment: c1
initial amount: 1.723
has property: MOD:00696
name: pp-AKT:PI3P
has only substance units: true
initial concentration: NaN

k5
units: inv subsec
value: 7.0E-4
type: LocalParameter

CDMT00077
stoichiometry: 1.0
species: s17
type: SpeciesReference

re18
type: Reaction
reactant: CDMT00094
kinetic law: CDMT00097
product: CDMT00095
modifier: CDMT00096
fast: false
reversible: false

c1
is: GO:0005623
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: Cell
type: Compartment

unimol
units: substance
value: 1.0
type: LocalParameter

time
unit: CDMT00272
name: time
type: SBMLUnitsDef

CDMT00114
stoichiometry: 1.0
species: s16
type: SpeciesReference

re1
fast: false
reactant: CDMT00068
type: Reaction
product: CDMT00069
modifier: CDMT00071
kinetic law: CDMT00072
modifier: CDMT00070
reversible: true

s21
in compartment: c1
initial amount: 0.0
is: SBO:0000291
name: s3
substance units: substance
has only substance units: true
constant: false
type: Species
initial concentration: NaN
boundary condition: false

s16
has only substance units: true
in compartment: c1
type: Species
boundary condition: false
initial concentration: NaN
is version of: P31749
initial amount: 167.616
name: AKT
substance units: substance
constant: false

CDMT00279
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

area
unit: CDMT00274
name: area
type: SBMLUnitsDef

k10
units: inv sec
value: 20.0
type: LocalParameter

re19
kinetic law: CDMT00132
fast: false
reversible: false
modifier: CDMT00108
reactant: CDMT00098
type: Reaction
product: CDMT00107

k2
units: inv sec
value: 0.2
type: LocalParameter

unity
units: dimensionless
value: 1.0
type: LocalParameter

CDMT00284
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

Km9
units: substance
value: 48000.0
type: LocalParameter

normal
units: sub sec
value: 0.907
type: LocalParameter

re21
reactant: CDMT00112
type: Reaction
fast: false
reversible: false
product: CDMT00114
kinetic law: CDMT00141
modifier: CDMT00115
product: CDMT00113

s20
has property: MOD:00696
has only substance units: true
in compartment: c1
initial amount: 0.03
boundary condition: false
name: p-PI3K
initial concentration: NaN
has property: IPR000403
substance units: substance
type: Species
constant: false

s15
type: Species
has only substance units: true
is version of: GO:0000159
boundary condition: false
initial concentration: NaN
name: PP2A
substance units: substance
in compartment: c1
initial amount: 150.0
constant: false

Km7
units: substance
value: 8800.0
type: LocalParameter

CDMT00313
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

k3
units: inv sec
value: 7.5
type: LocalParameter

CDMT00283
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

k11
units: inv sec
value: 0.163
type: LocalParameter

inv sec
unit: CDMT00279
name: inv_sec
type: SBMLUnitsDef

nM inv s
unit: CDMT00283
unit: CDMT00282
name: nM_inv_s
type: SBMLUnitsDef

CDMT00098
stoichiometry: 1.0
species: s26
type: SpeciesReference

Km8
units: substance
value: 80000.0
type: LocalParameter

s119
occurs in: GO:0005576
type: Species
substance units: substance
in compartment: default
initial amount: 0.0
has only substance units: true
initial concentration: NaN
name: Shear Stress
boundary condition: false
constant: false

re22
reversible: false
type: Reaction
kinetic law: CDMT00146
modifier: CDMT00118
product: CDMT00117
reactant: CDMT00116
fast: false

tf
units: substance
value: 15.0
type: LocalParameter

re13
kinetic law: CDMT00149
product: CDMT00120
reactant: CDMT00119
fast: false
reversible: false
type: Reaction

CDMT00282
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

CDMT00277
exponent: 1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

s14
boundary condition: false
initial concentration: NaN
constant: false
name: PDK1
type: Species
initial amount: 0.246
is version of: O15530
has only substance units: true
in compartment: c1
substance units: substance

k9
units: inv sec
value: 0.04
type: LocalParameter

volume
unit: CDMT00276
name: volume
type: SBMLUnitsDef

CDMT00272
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

s19
name: PIP2
substance units: substance
constant: false
type: Species
is version of: CHEBI:18348
has only substance units: true
initial amount: 6967.271
initial concentration: NaN
in compartment: c1
boundary condition: false

CDMT00069
stoichiometry: 1.0
species: s20
type: SpeciesReference

CDMT00095
stoichiometry: 1.0
species: s27
type: SpeciesReference

CDMT00074
stoichiometry: 1.0
species: s17
type: SpeciesReference

s23
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: c1
name: Time
type: Species

re2
kinetic law: CDMT00152
product: CDMT00122
reactant: CDMT00121
fast: false
reversible: false
type: Reaction

CDMT00112
stoichiometry: 1.0
species: s27
type: SpeciesReference

CDMT00081
stoichiometry: 1.0
species: s17
type: SpeciesReference

length
unit: CDMT00275
name: length
type: SBMLUnitsDef

re14
modifier: CDMT00075
type: Reaction
reactant: CDMT00073
reversible: false
product: CDMT00074
fast: false
kinetic law: CDMT00076

CDMT00281
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

CDMT00278
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

inv nM s
unit: CDMT00313
unit: CDMT00284
name: inv_nM_s
type: SBMLUnitsDef

CDMT00107
stoichiometry: 1.0
species: s28
type: SpeciesReference

re20
fast: false
reversible: false
product: CDMT00110
type: Reaction
modifier: CDMT00111
reactant: CDMT00109
kinetic law: CDMT00136

s22
initial concentration: NaN
has property: IPR000403
initial amount: 99.97
has only substance units: true
substance units: substance
boundary condition: false
type: Species
constant: false
name: PI3K
in compartment: c1

kr4
units: inv sec
value: 0.089
type: LocalParameter

Km2
units: substance
value: 6170.0
type: LocalParameter

CDMT00073
stoichiometry: 1.0
species: s19
type: SpeciesReference

CDMT00082
stoichiometry: 1.0
species: s16
type: SpeciesReference

CDMT00113
stoichiometry: 1.0
species: s17
type: SpeciesReference

substance
unit: CDMT00273
name: substance
type: SBMLUnitsDef

CDMT00280
exponent: -1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

s26
initial amount: 1.457
boundary condition: false
name: p-AKT:PI3P
constant: false
type: Species
has part: P31749
has part: http://identifiers.org/pubchem.compound/53480352
in compartment: c1
has only substance units: true
initial concentration: NaN
has property: MOD:00696
substance units: substance

re15
product: CDMT00078
reversible: false
reactant: CDMT00077
modifier: CDMT00079
fast: false
type: Reaction
kinetic law: CDMT00080

CDMT00274
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

CDMT00275
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

k7
units: inv sec
value: 0.037
type: LocalParameter

k6
units: inv sec
value: 0.98
type: LocalParameter

CDMT00083
stoichiometry: 1.0
species: s28
type: SpeciesReference

Km3
units: substance
value: 80.9
type: LocalParameter

CDMT00110
stoichiometry: 1.0
species: s26
type: SpeciesReference

re16
reactant: CDMT00081
product: CDMT00083
kinetic law: CDMT00084
reactant: CDMT00082
fast: false
reversible: true
type: Reaction

s25
name: PDK1_cyto
in compartment: c1
initial amount: 999.754
substance units: substance
occurs in: GO:0005622
constant: false
is version of: O15530
has only substance units: true
type: Species
initial concentration: NaN
boundary condition: false

default
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
type: Compartment

CDMT00119
stoichiometry: 1.0
species: s14
type: SpeciesReference

CDMT00122
stoichiometry: 1.0
species: s23
type: SpeciesReference

inv subsec
unit: CDMT00281
unit: CDMT00280
name: inv_sec_sub
type: SBMLUnitsDef

CDMT00276
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

CDMT00273
exponent: 1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

CDMT00109
stoichiometry: 1.0
species: s27
type: SpeciesReference

k8
units: inv sec
value: 20.0
type: LocalParameter

CDMT00094
stoichiometry: 1.0
species: s26
type: SpeciesReference

sub sec
unit: CDMT00278
unit: CDMT00277
name: sub_sec
type: SBMLUnitsDef

s24
in compartment: c1
initial amount: 3.0
initial concentration: NaN
name: PDK2
has only substance units: true
is version of: Q15119
substance units: substance
constant: false
type: Species
boundary condition: false