975435
stoichiometry: 1.0
species: 139730
type: SpeciesReference

975123
stoichiometry: 1.0
species: 139773
type: SpeciesReference

974691
stoichiometry: 1.0
species: 139794
type: SpeciesReference

974295
stoichiometry: 1.0
species: 139723
type: SpeciesReference

140065
constant: false
value: 12.0
type: Parameter

139681
has part: CHEMBL98350
has part: GO:0005942
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

139843
kinetic law: 974355
product: 974343
reactant: 974331
fast: true
reversible: false
name: R16_2
type: Reaction

140079
constant: false
value: 3.0
type: Parameter

140164
constant: false
value: 10.0
type: Parameter

139705
in compartment: 139677
has part: P62993
type: Species
has part: Q07890
has part: Q07889
boundary condition: false
initial amount: NaN
initial concentration: 100.0
has only substance units: false
constant: false

140150
constant: false
value: 15000.0
type: Parameter

140010
constant: false
value: 0.0
type: Parameter

140038
constant: false
value: 0.1
type: Parameter

974679
stoichiometry: 1.0
species: 139739
type: SpeciesReference

973684
stoichiometry: 1.0
species: 139684
type: SpeciesReference

140091
constant: false
value: 13520.0
type: Parameter

973756
stoichiometry: 1.0
species: 139693
type: SpeciesReference

973816
stoichiometry: 1.0
species: 139699
type: SpeciesReference

140165
constant: false
value: 100.0
type: Parameter

139706
has part: P62993
in compartment: 139677
has only substance units: false
has part: Q07890
has part: Q02297
has part: http://identifiers.org/ec-code/2.7.10.1
has part: P29353
has part: P21860
type: Species
boundary condition: false
has part: P04626
is version of: C00562
has part: Q07889
initial amount: NaN
constant: false
initial concentration: 0.0

139690
has only substance units: false
constant: false
has part: http://identifiers.org/ec-code/2.7.10.1
boundary condition: false
initial concentration: 0.0
has part: Q02297
type: Species
has part: P21860
initial amount: NaN
in compartment: 139677
has part: P04626

974475
stoichiometry: 1.0
species: 139723
type: SpeciesReference

140151
constant: false
value: 0.1
type: Parameter

139717
is version of: Q02750
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 139677
type: Species

975795
stoichiometry: 1.0
species: 139687
type: SpeciesReference

139831
kinetic law: 974176
modifier: 974164
product: 974152
reactant: 974140
fast: true
reversible: false
name: R13
type: Reaction

974283
stoichiometry: 1.0
species: 139720
type: SpeciesReference

140178
constant: false
value: 300.0
type: Parameter

975447
stoichiometry: 1.0
species: 139751
type: SpeciesReference

139845
kinetic law: 974451
modifier: 974439
product: 974427
reactant: 974415
fast: true
reversible: false
name: R17_1
type: Reaction

975855
stoichiometry: 1.0
species: 139714
type: SpeciesReference

140162
constant: false
value: 0.012
type: Parameter

139707
has part: AAC37531.1
initial concentration: 0.0
in compartment: 139677
type: Species
initial amount: NaN
constant: false
boundary condition: false
has part: P04626
is version of: http://identifiers.org/ec-code/2.7.10.1
has part: CHEMBL2007641
has only substance units: false

139739
is version of: C00562
is version of: P27361
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

974931
stoichiometry: 1.0
species: 139755
type: SpeciesReference

140026
constant: false
value: 10.0
type: Parameter

973672
stoichiometry: 1.0
species: 139687
type: SpeciesReference

139844
kinetic law: 974403
product: 974391
product: 974379
reactant: 974367
fast: true
reversible: false
name: R16_3
type: Reaction

140050
constant: false
value: 1.0
type: Parameter

974487
stoichiometry: 1.0
species: 139733
type: SpeciesReference

140163
constant: false
value: 100.0
type: Parameter

974523
stoichiometry: 1.0
species: 139726
type: SpeciesReference

139708
initial concentration: 0.0
has part: P60484
in compartment: 139677
boundary condition: false
constant: false
has part: AAH05821.1
has part: http://identifiers.org/pubchem.compound/16760324
initial amount: NaN
has only substance units: false
type: Species

973804
stoichiometry: 1.0
species: 139696
type: SpeciesReference

973792
stoichiometry: 1.0
species: 139693
type: SpeciesReference

140153
constant: false
value: 3.0
type: Parameter

140068
constant: false
value: 0.1
type: Parameter

140023
constant: false
value: 600.0
type: Parameter

140082
constant: false
value: 1.0
type: Parameter

140140
constant: false
value: 15.0
type: Parameter

139714
in compartment: 139677
initial amount: NaN
initial concentration: 0.0
has part: http://identifiers.org/ec-code/2.7.10.1
occurs in: GO:0005737
has part: P04626
constant: false
boundary condition: false
has part: Q02297
has part: P21860
has only substance units: false
type: Species

975411
stoichiometry: 1.0
species: 139730
type: SpeciesReference

140013
constant: false
value: 70.0
type: Parameter

140041
constant: false
value: 10.0
type: Parameter

140160
constant: false
value: 20000.0
type: Parameter

140003
constant: false
value: 65.0
type: Parameter

974607
stoichiometry: 1.0
species: 139739
type: SpeciesReference

140076
constant: false
value: 340.0
type: Parameter

140024
constant: false
value: 10.0
type: Parameter

140056
constant: false
value: 3.0
type: Parameter

140141
constant: false
value: 3.6
type: Parameter

139792
has part: P62993
initial amount: NaN
initial concentration: 0.0
boundary condition: false
type: Species
constant: false
has only substance units: false
has part: Q07889
has part: P29353
in compartment: 139677
has part: Q07890

140062
constant: false
value: 9.0
type: Parameter

139702
initial amount: NaN
is version of: C00562
in compartment: 139677
has only substance units: false
type: Species
initial concentration: 0.0
has part: P04626
has part: Q02297
has part: P21860
boundary condition: false
has part: http://identifiers.org/ec-code/2.7.10.1
has part: P29353
constant: false

974559
stoichiometry: 1.0
species: 139720
type: SpeciesReference

BIOMD0000000424
reaction: 139923
parameter: 140021
parameter: 140134
parameter: 140154
species: 139710
reaction: 139906
parameter: 140116
reaction: 139824
reaction: 139859
parameter: 140073
parameter: 140187
parameter: 140020
parameter: 140153
species: 139780
species: 139770
reaction: 139846
parameter: 140059
parameter: 140173
parameter: 140142
reaction: 139897
species: 139764
species: 139754
parameter: 140139
parameter: 140158
parameter: 140123
reaction: 139828
species: 139702
reaction: 139850
species: 139774
parameter: 140141
parameter: 140178
parameter: 140160
reaction: 139913
species: 139758
parameter: 140082
reaction: 139885
parameter: 140180
species: 139794
parameter: 140013
parameter: 140177
parameter: 140146
species: 139801
species: 139708
reaction: 139888
species: 139778
parameter: 140128
parameter: 140032
reaction: 139874
species: 139798
parameter: 140165
parameter: 140071
reaction: 139840
parameter: 140185
species: 139690
species: 139742
parameter: 140068
parameter: 140151
parameter: 140171
reaction: 139862
curated: true
parameter: 140004
parameter: 140023
parameter: 140137
parameter: 140156
species: 139684
parameter: 140094
species: 139748
reaction: 139909
reaction: 139826
substance units: substance
species: 139678
parameter: 140056
parameter: 140076
reaction: 139845
reaction: 139912
compartment: 139677
reaction: 139882
species: 139726
reaction: 139831
parameter: 140062

974655
stoichiometry: 1.0
species: 139736
type: SpeciesReference

975519
stoichiometry: 1.0
species: 139783
type: SpeciesReference

140004
constant: false
value: 10.0
type: Parameter

140161
constant: false
value: 0.6
type: Parameter

139727
has part: Q02750
has part: P63151
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

976047
stoichiometry: 1.0
species: 139681
type: SpeciesReference

974943
stoichiometry: 1.0
species: 139754
type: SpeciesReference

973732
stoichiometry: 1.0
species: 139693
type: SpeciesReference

140073
constant: false
value: 0.0154
type: Parameter

140035
constant: false
value: 1.0
type: Parameter

140094
constant: false
value: 0.0
type: Parameter

139693
initial concentration: 0.0
in compartment: 139677
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
has part: P04626
has part: http://identifiers.org/ec-code/2.7.10.1
is version of: C00562
has part: Q02297
has part: P21860

973624
stoichiometry: 1.0
species: 139678
type: SpeciesReference

975111
stoichiometry: 1.0
species: 139761
type: SpeciesReference

975327
stoichiometry: 1.0
species: 139775
type: SpeciesReference

140021
constant: false
value: 0.0
type: Parameter

140053
constant: false
value: 12.0
type: Parameter

975771
stoichiometry: 1.0
species: 139742
type: SpeciesReference

975879
stoichiometry: 1.0
species: 139714
type: SpeciesReference

139726
has only substance units: false
initial concentration: 0.0
is version of: C00562
has part: P63151
constant: false
has part: Q02750
in compartment: 139677
type: Species
initial amount: NaN
boundary condition: false

139840
kinetic law: 974319
product: 974307
reactant: 974295
reactant: 974283
fast: true
reversible: false
name: R16_1
type: Reaction

974547
stoichiometry: 1.0
species: 139726
type: SpeciesReference

139780
is version of: C00562
is version of: Q02750
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

140044
constant: false
value: 50.0
type: Parameter

974955
stoichiometry: 1.0
species: 139779
type: SpeciesReference

973720
stoichiometry: 1.0
species: 139690
type: SpeciesReference

140016
constant: false
value: 10.0
type: Parameter

140022
constant: false
value: 0.005
type: Parameter

139820
kinetic law: 973864
product: 973852
reactant: 973840
fast: true
reversible: false
name: R6
type: Reaction

975195
stoichiometry: 1.0
species: 139774
type: SpeciesReference

140002
constant: false
value: 30.0
type: Parameter

973696
stoichiometry: 1.0
species: 139690
type: SpeciesReference

140007
constant: false
value: 91.0
type: Parameter

973936
stoichiometry: 1.0
species: 139693
type: SpeciesReference

140071
constant: false
value: 35.0
type: Parameter

975375
stoichiometry: 1.0
species: 139758
type: SpeciesReference

975315
stoichiometry: 1.0
species: 139751
type: SpeciesReference

975651
stoichiometry: 1.0
species: 139693
type: SpeciesReference

975999
stoichiometry: 1.0
species: 139761
type: SpeciesReference

140085
constant: false
value: 300.0
type: Parameter

140072
constant: false
value: 0.0
type: Parameter

976035
stoichiometry: 1.0
species: 139745
type: SpeciesReference

974056
stoichiometry: 1.0
species: 139709
type: SpeciesReference

140019
constant: false
value: 0.0
type: Parameter

974140
stoichiometry: 1.0
species: 139711
type: SpeciesReference

974343
stoichiometry: 1.0
species: 139727
type: SpeciesReference

140088
constant: false
value: 0.0
type: Parameter

973948
stoichiometry: 1.0
species: 139792
type: SpeciesReference

974331
stoichiometry: 1.0
species: 139726
type: SpeciesReference

974871
stoichiometry: 1.0
species: 139754
type: SpeciesReference

139999
constant: false
value: 0.6
type: Parameter

140097
constant: false
value: 900.0
type: Parameter

975399
stoichiometry: 1.0
species: 139758
type: SpeciesReference

974200
stoichiometry: 1.0
species: 139711
type: SpeciesReference

139709
has part: P01116
has part: CHEBI:17552
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120.0
initial amount: NaN
in compartment: 139677
type: Species

974427
stoichiometry: 1.0
species: 139780
type: SpeciesReference

974152
stoichiometry: 1.0
species: 139795
type: SpeciesReference

974379
stoichiometry: 1.0
species: 139717
type: SpeciesReference

974811
stoichiometry: 1.0
species: 139748
type: SpeciesReference

974068
stoichiometry: 1.0
species: 139798
type: SpeciesReference

974787
stoichiometry: 1.0
species: 139748
type: SpeciesReference

139847
kinetic law: 974535
product: 974523
reactant: 974511
fast: true
reversible: false
name: R18_2
type: Reaction

139846
kinetic law: 974499
product: 974487
reactant: 974475
reactant: 974463
fast: true
reversible: false
name: R18_1
type: Reaction

975459
stoichiometry: 1.0
species: 139723
type: SpeciesReference

974739
stoichiometry: 1.0
species: 139739
type: SpeciesReference

974991
stoichiometry: 1.0
species: 139761
type: SpeciesReference

139941
kinetic law: 975987
product: 975975
product: 975963
reactant: 975951
fast: true
reversible: false
name: R42
type: Reaction

975147
stoichiometry: 1.0
species: 139761
type: SpeciesReference

139996
constant: false
value: 1.0
type: Parameter

974367
stoichiometry: 1.0
species: 139727
type: SpeciesReference

974415
stoichiometry: 1.0
species: 139720
type: SpeciesReference

140029
constant: false
value: 0.01
type: Parameter

976011
stoichiometry: 1.0
species: 139708
type: SpeciesReference

139859
kinetic law: 974715
modifier: 974703
product: 974691
reactant: 974679
fast: true
reversible: false
name: R21
type: Reaction

974823
stoichiometry: 1.0
species: 139777
type: SpeciesReference

139995
constant: false
value: 0.0
type: Parameter

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

975159
stoichiometry: 1.0
species: 139773
type: SpeciesReference

974895
stoichiometry: 1.0
species: 139754
type: SpeciesReference

975231
stoichiometry: 1.0
species: 139778
type: SpeciesReference

974727
stoichiometry: 1.0
species: 139794
type: SpeciesReference

139874
kinetic law: 974967
product: 974955
reactant: 974943
reactant: 974931
fast: true
reversible: false
name: R27_1
type: Reaction

974463
stoichiometry: 1.0
species: 139780
type: SpeciesReference

139808
kinetic law: 973708
product: 973696
reactant: 973684
reactant: 973672
fast: true
reversible: false
name: R2
type: Reaction

974104
stoichiometry: 1.0
species: 139798
type: SpeciesReference

139888
kinetic law: 975219
product: 975207
reactant: 975195
fast: true
reversible: false
name: R28_6
type: Reaction

973840
stoichiometry: 1.0
species: 139699
type: SpeciesReference

139868
kinetic law: 974835
product: 974823
reactant: 974811
fast: true
reversible: false
name: R24
type: Reaction

975039
stoichiometry: 1.0
species: 139770
type: SpeciesReference

140139
constant: false
value: 0.01
type: Parameter

974775
stoichiometry: 1.0
species: 139745
type: SpeciesReference

139903
kinetic law: 975423
product: 975411
reactant: 975399
fast: true
reversible: false
name: R31_2
type: Reaction

139894
kinetic law: 975303
product: 975291
reactant: 975279
reactant: 975267
fast: true
reversible: false
name: R29
type: Reaction

139789
notes: Kinetic equations are usually written in terms of concentrations (not of mole numbers), since the reaction rates are functions of concentrations. If the same compound participates in reactions taking place in different compartments with different volumes, the effective concentration of that compound will be different depending on the volume of the corresponding compartment. Step 1 (EGF binding to EGFR) could be considered as taking place in the extracellular compartment with a given initial concentration of EGF. The concentration of EGFR in the extracellular compartment would then be calculated as the number of the receptors on the cell surface divided by the (average) volume of incubation medium per cell (V m). In step 2, association and dissociation of the receptor monomers occurs in the cell membrane. All other steps are considered as taking place in the cytosolic compartment. Therefore, the same mole number of EGFR would give rise to three EGFR concentrations (representing the different compartments). However, for computational purposes, it is more convenient to deal only with a single concentration of EGFR related to the cytoplasmic water volume (V cw) of the cell. This requires rescaling the rate constants of steps 1 and 2. For the purpose of this rescaling, the EGF concentration in the model was also related to the cytoplasmic water volume; i.e. [EGF] in the experimental medium was multiplied by the ratio Vm/V cw (see TableII). Typically, there were 107cells/ml in our experiments (see “Cell Preparation and Incubation Conditions”); therefore, Vm = 10−7 ml. Assuming the diameter of a hepatocyte of 20 μm and a cytoplasmic water volume of about 70% of total intracellular volume, Vm/Vcw = 33.3. [taken from Kholodenko 1999; http://www.jbc.org/content/274/42/30169.long] Per = 0 [without Inhibitor Pertuzumab] Per = 300000 [with Inhibitor Pertuzumab] - Stuart Moodie
is version of: CHEMBL2007641
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

139944
kinetic law: 976023
product: 976011
reactant: 975999
fast: true
reversible: false
name: R43
type: Reaction

975927
stoichiometry: 1.0
species: 139710
type: SpeciesReference

974188
stoichiometry: 1.0
species: 139795
type: SpeciesReference

973900
stoichiometry: 1.0
species: 139706
type: SpeciesReference

140125
constant: false
value: 1.0
type: Parameter

139906
kinetic law: 975471
product: 975459
product: 975447
reactant: 975435
fast: true
reversible: false
name: R31_3
type: Reaction

975243
stoichiometry: 2.0
species: 139761
type: SpeciesReference

975291
stoichiometry: 1.0
species: 139751
type: SpeciesReference

974116
stoichiometry: 1.0
species: 139709
type: SpeciesReference

975951
stoichiometry: 1.0
species: 139710
type: SpeciesReference

139897
kinetic law: 975339
product: 975327
reactant: 975315
fast: true
reversible: false
name: R30
type: Reaction

140122
constant: false
value: 1.0
type: Parameter

139856
kinetic law: 974667
product: 974655
reactant: 974643
fast: true
reversible: false
name: R20
type: Reaction

139877
kinetic law: 975015
product: 975003
reactant: 974991
reactant: 974979
fast: true
reversible: false
name: R28_1
type: Reaction

139932
kinetic law: 975867
product: 975855
reactant: 975843
fast: true
reversible: false
name: R39
type: Reaction

974763
stoichiometry: 1.0
species: 139693
type: SpeciesReference

974859
stoichiometry: 1.0
species: 139693
type: SpeciesReference

975603
stoichiometry: 1.0
species: 139758
type: SpeciesReference

974907
stoichiometry: 1.0
species: 139745
type: SpeciesReference

140123
constant: false
value: 0.06
type: Parameter

973984
stoichiometry: 1.0
species: 139705
type: SpeciesReference

140120
constant: false
value: 7.0
type: Parameter

139891
kinetic law: 975255
product: 975243
reactant: 975231
fast: true
reversible: false
name: R28_7
type: Reaction

139850
kinetic law: 974583
product: 974571
product: 974559
reactant: 974547
fast: true
reversible: false
name: R18_3
type: Reaction

975963
stoichiometry: 1.0
species: 139754
type: SpeciesReference

975279
stoichiometry: 1.0
species: 139764
type: SpeciesReference

139947
kinetic law: 976059
product: 976047
reactant: 976035
fast: true
reversible: false
name: R44
type: Reaction

139751
has part: http://identifiers.org/pubchem.compound/24755492
has part: P31749
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

975363
stoichiometry: 1.0
species: 139723
type: SpeciesReference

973924
stoichiometry: 1.0
species: 139706
type: SpeciesReference

140121
constant: false
value: 2.1
type: Parameter

975615
stoichiometry: 1.0
species: 139775
type: SpeciesReference

975819
stoichiometry: 1.0
species: 139690
type: SpeciesReference

139779
has part: CHEBI:16618
has part: CHEBI:15552
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

139938
kinetic law: 975939
product: 975927
reactant: 975915
fast: true
reversible: false
name: R41
type: Reaction

974847
stoichiometry: 1.0
species: 139777
type: SpeciesReference

139865
kinetic law: 974799
product: 974787
reactant: 974775
reactant: 974763
fast: true
reversible: false
name: R23
type: Reaction

139917
kinetic law: 975663
reactant: 975651
fast: true
reversible: false
name: R34
type: Reaction

974032
stoichiometry: 1.0
species: 139696
type: SpeciesReference

973996
stoichiometry: 1.0
species: 139801
type: SpeciesReference

975027
stoichiometry: 1.0
species: 139767
type: SpeciesReference

139935
kinetic law: 975903
product: 975891
reactant: 975879
fast: true
reversible: false
name: R40
type: Reaction

140181
constant: false
value: 10.0
type: Parameter

139778
is version of: GO:0043234
is version of: P60484
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.955337
initial amount: NaN
in compartment: 139677
type: Species

139862
kinetic law: 974751
product: 974739
reactant: 974727
fast: true
reversible: false
name: R22
type: Reaction

975267
stoichiometry: 1.0
species: 139776
type: SpeciesReference

975975
stoichiometry: 1.0
species: 139764
type: SpeciesReference

139909
kinetic law: 975507
product: 975495
reactant: 975483
fast: true
reversible: false
name: R32
type: Reaction

975915
stoichiometry: 1.0
species: 139779
type: SpeciesReference

975351
stoichiometry: 1.0
species: 139775
type: SpeciesReference

140180
constant: false
value: 0.0
type: Parameter

139929
kinetic law: 975831
product: 975819
reactant: 975807
reactant: 975795
fast: true
reversible: false
name: R38
type: Reaction

974020
stoichiometry: 1.0
species: 139801
type: SpeciesReference

139853
kinetic law: 974631
modifier: 974619
product: 974607
reactant: 974595
fast: true
reversible: false
name: R19
type: Reaction

139777
is version of: C00562
has only substance units: false
type: Species
in compartment: 139677
is version of: GO:0005942
initial amount: NaN
initial concentration: 0.0
has part: Q02297
constant: false
has part: P04626
has part: P21860
boundary condition: false

139767
has part: http://identifiers.org/pubchem.compound/24755492
has part: P60484
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.14554E-8
initial amount: NaN
in compartment: 139677
type: Species

975627
stoichiometry: 1.0
species: 139723
type: SpeciesReference

139755
is version of: C01312
is version of: CHEBI:15552
constant: false
boundary condition: false
has only substance units: false
initial concentration: 300.0
initial amount: NaN
in compartment: 139677
type: Species

140020
constant: false
value: 0.0
type: Parameter

140145
constant: false
value: 2.2
type: Parameter

140173
constant: false
value: 0.0
type: Parameter

140118
constant: false
value: 0.6
type: Parameter

139914
kinetic law: 975639
product: 975627
product: 975615
reactant: 975603
fast: true
reversible: false
name: R33_3
type: Reaction

974643
stoichiometry: 1.0
species: 139739
type: SpeciesReference

973768
stoichiometry: 1.0
species: 139690
type: SpeciesReference

139828
kinetic law: 974128
product: 974116
reactant: 974104
fast: true
reversible: false
name: R12
type: Reaction

140183
constant: false
value: 10.0
type: Parameter

139776
is version of: P31749
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: 139677
type: Species

139880
kinetic law: 975051
product: 975039
reactant: 975027
fast: true
reversible: false
name: R28_2
type: Reaction

975723
stoichiometry: 1.0
species: 139707
type: SpeciesReference

140159
constant: false
value: 0.003
type: Parameter

975687
stoichiometry: 1.0
species: 139789
type: SpeciesReference

139710
has part: http://identifiers.org/pubchem.compound/24755492
has part: GO:0005942
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

140131
constant: false
value: 1.8
type: Parameter

139678
is version of: P21860
is version of: http://identifiers.org/ec-code/2.7.10.1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 80.0
initial amount: NaN
in compartment: 139677
type: Species

140172
constant: false
value: 0.0
type: Parameter

974236
stoichiometry: 1.0
species: 139717
type: SpeciesReference

139913
kinetic law: 975591
product: 975579
reactant: 975567
fast: true
reversible: false
name: R33_2
type: Reaction

139699
has part: P04626
type: Species
initial amount: NaN
has part: P21860
initial concentration: 0.0
has only substance units: false
has part: P29353
in compartment: 139677
is version of: C00562
has part: http://identifiers.org/ec-code/2.7.10.1
constant: false
has part: Q02297
boundary condition: false

139811
kinetic law: 973744
product: 973732
reactant: 973720
fast: true
reversible: false
name: R3
type: Reaction

140144
constant: false
value: 1.0
type: Parameter

139742
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
in compartment: 139677
occurs in: GO:0005737
has part: P21860
has part: http://identifiers.org/ec-code/2.7.10.1
type: Species
has part: Q02297
initial concentration: 0.0

974595
stoichiometry: 1.0
species: 139736
type: SpeciesReference

139801
is version of: C00562
is version of: P29353
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

140119
constant: false
value: 50.0
type: Parameter

139775
initial concentration: 0.0
constant: false
has part: P31749
in compartment: 139677
is version of: C00562
has only substance units: false
has part: http://identifiers.org/pubchem.compound/24755492
type: Species
boundary condition: false
initial amount: NaN

140182
constant: false
value: 100.0
type: Parameter

139761
is version of: C05981
has only substance units: false
boundary condition: false
constant: false
is version of: http://identifiers.org/ec-code/3.1.3.16
in compartment: 139677
is version of: P60484
initial concentration: 42.7798
initial amount: NaN
type: Species

140158
constant: false
value: 0.001
type: Parameter

139881
kinetic law: 975099
product: 975087
product: 975075
reactant: 975063
fast: true
reversible: false
name: R28_3
type: Reaction

973888
stoichiometry: 1.0
species: 139705
type: SpeciesReference

139923
kinetic law: 975747
product: 975735
reactant: 975723
fast: true
reversible: false
name: R36
type: Reaction

139795
is version of: P04049
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

140130
constant: false
value: 10.0
type: Parameter

140059
constant: false
value: 36.0
type: Parameter

139736
is version of: P27361
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 139677
type: Species

975567
stoichiometry: 1.0
species: 139786
type: SpeciesReference

974307
stoichiometry: 1.0
species: 139726
type: SpeciesReference

139696
is: P29353
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: 139677
type: Species

139764
initial concentration: 8.05772E-12
type: Species
in compartment: 139677
is version of: C05981
initial amount: NaN
is version of: CHEBI:16618
boundary condition: false
constant: false
is version of: http://identifiers.org/pubchem.compound/24755492
has only substance units: false

140171
constant: false
value: 0.0
type: Parameter

139826
kinetic law: 974044
product: 974032
reactant: 974020
fast: true
reversible: false
name: R10
type: Reaction

139774
is version of: P60484
constant: false
is version of: GO:0043234
type: Species
in compartment: 139677
boundary condition: false
initial amount: NaN
has only substance units: false
is version of: C00562
initial concentration: 0.955337

140032
constant: false
value: 0.01
type: Parameter

139926
kinetic law: 975783
product: 975771
reactant: 975759
fast: true
reversible: false
name: R37
type: Reaction

140185
constant: false
value: 100.0
type: Parameter

140133
constant: false
value: 0.03
type: Parameter

139723
is version of: P63151
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 139677
type: Species

975087
stoichiometry: 1.0
species: 139761
type: SpeciesReference

ORG:
  orgname: EMBL-EBI
n:
  given: Stuart
  family: Moodie

975807
stoichiometry: 1.0
species: 139742
type: SpeciesReference

975735
stoichiometry: 1.0
species: 139793
type: SpeciesReference

139912
kinetic law: 975555
product: 975543
reactant: 975531
reactant: 975519
fast: true
reversible: false
name: R33_1
type: Reaction

139733
initial concentration: 0.0
has part: P63151
constant: false
type: Species
boundary condition: false
in compartment: 139677
is version of: C00562
has only substance units: false
initial amount: NaN
has part: Q02750

975675
stoichiometry: 1.0
species: 139687
type: SpeciesReference

139794
is version of: C00562
is version of: P27361
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

140143
constant: false
value: 2.0
type: Parameter

139754
is version of: GO:0005942
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

140170
constant: false
value: 0.0
type: Parameter

139827
kinetic law: 974092
modifier: 974080
product: 974068
reactant: 974056
fast: true
reversible: false
name: R11
type: Reaction

139773
is version of: C00562
is version of: P60484
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.39885
initial amount: NaN
in compartment: 139677
type: Species

974248
stoichiometry: 1.0
species: 139720
type: SpeciesReference

140184
constant: false
value: 10.0
type: Parameter

139783
initial concentration: 0.0
in compartment: 139677
has part: http://identifiers.org/pubchem.compound/24755492
boundary condition: false
initial amount: NaN
has part: P31749
constant: false
is version of: C00562
has only substance units: false
type: Species

140047
constant: false
value: 0.06
type: Parameter

140132
constant: false
value: 10.0
type: Parameter

975579
stoichiometry: 1.0
species: 139758
type: SpeciesReference

139711
is version of: P04049
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: 139677
type: Species

139677
is: GO:0005886
is: SBO:0000410
constant: false
size: 1.0
spatial dimensions: 3.0
type: Compartment

140142
constant: false
value: 150.0
type: Parameter

973876
stoichiometry: 1.0
species: 139702
type: SpeciesReference

139793
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false
occurs in: GO:0005737
initial concentration: 0.0
has part: P04626
in compartment: 139677
has part: CHEMBL2007641

973972
stoichiometry: 1.0
species: 139792
type: SpeciesReference

975003
stoichiometry: 1.0
species: 139767
type: SpeciesReference

975483
stoichiometry: 1.0
species: 139775
type: SpeciesReference

140128
constant: false
value: 0.06
type: Parameter

140135
constant: false
value: 30.0
type: Parameter

140187
constant: false
value: 100.0
type: Parameter

139745
is version of: GO:0005942
constant: false
boundary condition: false
has only substance units: false
initial concentration: 200.0
initial amount: NaN
in compartment: 139677
type: Species

139900
kinetic law: 975387
product: 975375
reactant: 975363
reactant: 975351
fast: true
reversible: false
name: R31_1
type: Reaction

975171
stoichiometry: 1.0
species: 139774
type: SpeciesReference

140149
constant: false
value: 20.0
type: Parameter

975531
stoichiometry: 1.0
species: 139723
type: SpeciesReference

975075
stoichiometry: 1.0
species: 139755
type: SpeciesReference

140177
constant: false
value: 50.0
type: Parameter

139814
kinetic law: 973780
product: 973768
reactant: 973756
fast: true
reversible: false
name: R4
type: Reaction

139786
in compartment: 139677
boundary condition: false
has part: P63151
constant: false
initial concentration: 0.0
has part: P31749
is version of: C00562
initial amount: NaN
has only substance units: false
type: Species
has part: http://identifiers.org/pubchem.compound/24755492

140108
constant: false
value: 0.18
type: Parameter

139684
initial concentration: 0.0
type: Species
in compartment: 139677
initial amount: NaN
has only substance units: false
has part: http://identifiers.org/ec-code/2.7.10.1
constant: false
boundary condition: false
has part: P21860
has part: Q02297

140169
constant: false
value: 0.0
type: Parameter

139834
kinetic law: 974224
modifier: 974211
product: 974200
reactant: 974188
fast: true
reversible: false
name: R14
type: Reaction

140155
constant: false
value: 45.0
type: Parameter

139824
kinetic law: 973960
product: 973948
product: 973936
reactant: 973924
fast: true
reversible: false
name: R8
type: Reaction

139804
is version of: Q02297
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3000.0
initial amount: NaN
in compartment: 139677
type: Species

974979
stoichiometry: 1.0
species: 139764
type: SpeciesReference

139920
kinetic law: 975711
product: 975699
reactant: 975687
reactant: 975675
fast: true
reversible: false
name: R35
type: Reaction

140186
constant: false
value: 120.0
type: Parameter

140129
constant: false
value: 1.2
type: Parameter

140134
constant: false
value: 100.0
type: Parameter

140154
constant: false
value: 0.1
type: Parameter

139825
kinetic law: 974008
product: 973996
product: 973984
reactant: 973972
fast: true
reversible: false
name: R9
type: Reaction

140148
constant: false
value: 15000.0
type: Parameter

975543
stoichiometry: 1.0
species: 139786
type: SpeciesReference

140176
constant: false
value: 200.0
type: Parameter

140115
constant: false
value: 0.1
type: Parameter

973648
stoichiometry: 1.0
species: 139684
type: SpeciesReference

140168
constant: false
value: 0.0
type: Parameter

139871
kinetic law: 974883
product: 974871
product: 974859
reactant: 974847
fast: true
reversible: false
name: R25
type: Reaction

140109
constant: false
value: 3.0
type: Parameter

139885
kinetic law: 975183
product: 975171
reactant: 975159
reactant: 975147
fast: true
reversible: false
name: R28_5
type: Reaction

974571
stoichiometry: 1.0
species: 139723
type: SpeciesReference

139805
kinetic law: 973660
product: 973648
reactant: 973636
reactant: 973624
fast: true
reversible: false
name: R1
type: Reaction

140137
constant: false
value: 8000.0
type: Parameter

974391
stoichiometry: 1.0
species: 139723
type: SpeciesReference

140126
constant: false
value: 0.6
type: Parameter

975063
stoichiometry: 1.0
species: 139770
type: SpeciesReference

975495
stoichiometry: 1.0
species: 139783
type: SpeciesReference

140116
constant: false
value: 1.0
type: Parameter

140175
constant: false
value: -2920.0
type: Parameter

975891
stoichiometry: 1.0
species: 139693
type: SpeciesReference

974511
stoichiometry: 1.0
species: 139733
type: SpeciesReference

140147
constant: false
value: 150.0
type: Parameter

975699
stoichiometry: 1.0
species: 139707
type: SpeciesReference

139770
has part: P60484
has part: CHEBI:15552
constant: false
boundary condition: false
has only substance units: false
initial concentration: 5.02914E-8
initial amount: NaN
in compartment: 139677
type: Species

975207
stoichiometry: 1.0
species: 139778
type: SpeciesReference

140167
constant: false
value: 80.0
type: Parameter

975759
stoichiometry: 1.0
species: 139684
type: SpeciesReference

139798
has part: P01116
has part: CHEBI:15996
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

139882
kinetic law: 975135
product: 975123
reactant: 975111
fast: true
reversible: false
name: R28_4
type: Reaction

140157
constant: false
value: 0.3
type: Parameter

140136
constant: false
value: 30.0
type: Parameter

140127
constant: false
value: 0.6
type: Parameter

140146
constant: false
value: 150.0
type: Parameter

140117
constant: false
value: 11.7
type: Parameter

140174
constant: false
value: 2900.0
type: Parameter

139758
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 0.0
has part: P31749
constant: false
in compartment: 139677
is version of: C00562
type: Species
has part: P63151
has part: http://identifiers.org/pubchem.compound/24755492

973852
stoichiometry: 1.0
species: 139702
type: SpeciesReference

139837
kinetic law: 974272
modifier: 974259
product: 974248
reactant: 974236
fast: true
reversible: false
name: R15
type: Reaction

139730
type: Species
constant: false
initial concentration: 0.0
has only substance units: false
has part: P31749
in compartment: 139677
has part: P63151
boundary condition: false
initial amount: NaN
has part: http://identifiers.org/pubchem.compound/24755492

W3 CDTF: Thu Aug 18 13:13:07 BST 2011

139817
kinetic law: 973828
product: 973816
reactant: 973804
reactant: 973792
fast: true
reversible: false
name: R5
type: Reaction

975843
stoichiometry: 1.0
species: 139690
type: SpeciesReference

973636
stoichiometry: 1.0
species: 139804
type: SpeciesReference

140188
constant: false
value: 100.0
type: Parameter

139720
is version of: C00562
is version of: Q02750
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 139677
type: Species

140107
constant: false
value: 6.0
type: Parameter

139873
kinetic law: 974919
product: 974907
reactant: 974895
fast: true
reversible: false
name: R26
type: Reaction

139823
kinetic law: 973912
product: 973900
reactant: 973888
reactant: 973876
fast: true
reversible: false
name: R7
type: Reaction

139687
is version of: P04626
is version of: http://identifiers.org/ec-code/2.7.10.1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: 139677
type: Species

140156
constant: false
value: 30.0
type: Parameter

139748
has part: P21860
is version of: GO:0005942
type: Species
has part: http://identifiers.org/ec-code/2.7.10.1
has part: P04626
has part: Q02297
constant: false
in compartment: 139677
boundary condition: false
has only substance units: false
initial concentration: 0.0
is version of: C00562
initial amount: NaN

W3 CDTF: Thu Aug 09 17:20:50 BST 2012