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constant: true
size: 1.0
spatial dimensions: 3.0
name: Compartment
type: Compartment

metaid_0000051
is: SBO:0000009
constant: true
value: 12.0
name: theta_m
type: Parameter

metaid_0000066
constant: false
value: 6.0
name: i_K_ATP
type: Parameter

metaid_0000045
is: SBO:0000345
constant: true
value: 20.0
name: tau
type: Parameter

metaid_0000064
is: SBO:0000009
constant: true
value: 8.0
name: theta_s
type: Parameter

metaid_0000055
constant: false
value: 1.89405943825186E-4
name: n_infinity
type: Parameter

metaid_0000053
is: SBO:0000009
constant: true
value: -75.0
name: V_K
type: Parameter

metaid_0000047
is: SBO:0000009
constant: true
value: 3.6
name: g_Ca
type: Parameter

metaid_0000060
constant: false
value: 1.0
name: i_s
type: Parameter

metaid_0000062
constant: false
value: 0.00460957217937421
name: s_infinity
type: Parameter

metaid_0000057
is: SBO:0000009
constant: true
value: 5.6
name: theta_n
type: Parameter

metaid_0000043
is version of: GO:0005251
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.05
in compartment: metaid_0000031
name: n
type: Species

metaid_0000059
is: SBO:0000345
constant: true
value: 20.0
name: tau_2
type: Parameter

BIOMD0000000371
parameter: metaid_0000066
is: MODEL0911270002
modified:
  W3 CDTF: Thu Mar 08 12:39:46 GMT 2012
creator:
  ORG:
    orgname: The University of Auckland,The Bioengineering Institute
  n:
    given: Catherine
    family: Lloyd
rule: metaid_0000038
parameter: metaid_0000050
area units: 498119
parameter: metaid_0000052
length unit: length
rule: metaid_0000036
name: DeVries2000_PancreaticBetaCells_InsulinSecretion
compartment: metaid_0000031
rule: metaid_0000041
parameter: metaid_0000029
parameter: metaid_0000046
parameter: metaid_0000047
parameter: metaid_0000053
species: metaid_0000044
parameter: metaid_0000054
substance units: 709238
parameter: metaid_0000056
rule: metaid_0000040
volume units: 498095
parameter: metaid_0000049
parameter: metaid_0000051
is described by: http://identifiers.org/pubmed/11093836
rule: metaid_0000035
parameter: metaid_0000057
parameter: metaid_0000061
parameter: metaid_0000063
parameter: metaid_0000058
parameter: metaid_0000030
rule: metaid_0000033
species: metaid_0000043
rule: metaid_0000037
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Ishan
    family: Ajmera
parameter: metaid_0000048
created:
  W3 CDTF: Wed Sep 28 22:16:51 BST 2011
parameter: metaid_0000060
parameter: metaid_0000055
parameter: metaid_0000065
rule: metaid_0000032
rule: metaid_0000039
time units: 709214
is version of: GO:0030073
rule: metaid_0000034
parameter: metaid_0000062
parameter: metaid_0000064
parameter: metaid_0000045
parameter: metaid_0000059
is version of: GO:0044342
species: metaid_0000042
type: SBMLModel
notes: This a model from the article: Channel sharing in pancreatic beta -cells revisited: enhancement of emergent bursting by noise. De Vries G, Sherman A. J Theor Biol 2000 Dec 21;207(4):513-30 11093836 , Abstract: Secretion of insulin by electrically coupled populations of pancreatic beta -cells is governed by bursting electrical activity. Isolated beta -cells, however, exhibit atypical bursting or continuous spike activity. We study bursting as an emergent property of the population, focussing on interactions among the subclass of spiking cells. These are modelled by equipping the fast subsystem with a saddle-node-loop bifurcation, which makes it monostable. Such cells can only spike tonically or remain silent when isolated, but can be induced to burst with weak diffusive coupling. With stronger coupling, the cells revert to tonic spiking. We demonstrate that the addition of noise dramatically increases, via a phenomenon like stochastic resonance, the coupling range over which bursting is seen. Copyright 2000 Academic Press. This model was taken from the CellML repository and automatically converted to SBML. The original model was: De Vries G, Sherman A. (2000) - version01 This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. For more information see the terms of use . To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
occurs in: http://identifiers.org/taxonomy/9606
curated: true
occurs in: BTO:0000783

metaid_0000050
is: SBO:0000009
constant: true
value: -20.0
name: V_m
type: Parameter

metaid_0000030
constant: true
value: 1.2
name: g_K_ATP
type: Parameter

metaid_0000052
constant: false
value: 5.0
name: i_K
type: Parameter

metaid_0000029
is: SBO:0000345
constant: true
value: 20000.0
name: tau_s
type: Parameter

metaid_0000065
is: SBO:0000009
constant: true
value: 0.5
name: p
type: Parameter

metaid_0000063
is: SBO:0000009
constant: true
value: -22.0
name: V_s
type: Parameter

metaid_0000049
constant: false
value: 0.0229773699100256
name: m_infinity
type: Parameter

metaid_0000046
constant: false
value: -7.4446678508483
name: i_Ca
type: Parameter

metaid_0000048
is: SBO:0000009
constant: true
value: 25.0
name: V_Ca
type: Parameter

metaid_0000054
is: SBO:0000009
constant: true
value: 10.0
name: g_K
type: Parameter

metaid_0000056
is: SBO:0000009
constant: true
value: -17.0
name: V_n
type: Parameter

metaid_0000044
is: PATO:0001227
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.025
in compartment: metaid_0000031
name: s
type: Species

metaid_0000058
is: SBO:0000009
constant: true
value: 0.8
name: lamda
type: Parameter

metaid_0000061
is: SBO:0000009
constant: true
value: 4.0
name: g_s
type: Parameter

metaid_0000042
is: PATO:0001462
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: -65.0
in compartment: metaid_0000031
name: V_membrane
type: Species