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BIOMD0000000351
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  W3 CDTF: Tue Aug 23 15:13:38 BST 2011
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created:
  W3 CDTF: Fri Apr 01 11:17:29 BST 2011
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notes: This model is from the article: The auxin signalling network translates dynamic input into robust patterning at the shoo t apex. Vernoux T, Brunoud G, Farcot E, Morin V, Van den Daele H, Legrand J, Oliva M, Das P, Larrieu A, Wells D , Guédon Y, Armitage L, Picard F, Guyomarc'h S, Cellier C, Parry G, Koumproglou R, Doonan JH, Estelle M , Godin C, Kepinski S, Bennett M, De Veylder L, Traas J. Mol Syst Biol. 2011 Jul 5;7:508. 21734647 , Abstract: The plant hormone auxin is thought to provide positional information for patterning during development. It is still unclear, however, precisely how auxin is distributed across tissues and how the hormone is sensed in space and time. The control of gene expression in response to auxin involves a complex netwo rk of over 50 potentially interacting transcriptional activators and repressors, the auxin response fac tors (ARFs) and Aux/IAAs. Here, we perform a large-scale analysis of the Aux/IAA-ARF pathway in the sho ot apex of Arabidopsis, where dynamic auxin-based patterning controls organogenesis. A comprehensive ex pression map and full interactome uncovered an unexpectedly simple distribution and structure of this p athway in the shoot apex. A mathematical model of the Aux/IAA-ARF network predicted a strong buffering capacity along with spatial differences in auxin sensitivity. We then tested and confirmed these predic tions using a novel auxin signalling sensor that reports input into the signalling pathway, in conjunct ion with the published DR5 transcriptional output reporter. Our results provide evidence that the auxin signalling network is essential to create robust patterns at the shoot apex. Note: Figure 3 of the supplementary material of the reference article has been reproduced here. Time evolution of all the variables in the model are plotted, under the influence of a step input of auxin level (auxin=5, when time>1000; 0.11, otherwise). pi_A is varied between 0 and 2 by steps of 0.1. This model originates from BioMod…
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  n:
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name: Vernoux2011_AuxinSignaling_AuxinSingleStepInput
occurs in: http://identifiers.org/taxonomy/3701
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metaid_0000013
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metaid_0000044
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metaid_0000005
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metaid_0000012
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metaid_0000019
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469408
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metaid_0000045
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is version of: GO:0009056
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metaid_0000006
notes: Auxin target gene mRNA degradation rate. Computed from the mean half life of Aux/IAA mRNA in Narsai et al. The Plant Cell 2007.
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