min
unit: CDMT00138
name: minute
type: SBMLUnitsDef

CDMT00017
stoichiometry: 1.0
species: T2R surf
type: SpeciesReference

CDMT00027
stoichiometry: 1.0
species: T2R surf
type: SpeciesReference

CDMT00040
stoichiometry: 1.0
species: empty degraded
type: SpeciesReference

CDMT00082
stoichiometry: 1.0
species: PSmad2 PSmad2 c
type: SpeciesReference

CDMT00057
stoichiometry: 1.0
species: Smad2c
type: SpeciesReference

CDMT00067
stoichiometry: 1.0
species: PSmad2c
type: SpeciesReference

Smad2n
type: Species
is version of: Q15796
in compartment: Vnuc
is: SBO:0000252
substance units: nM
boundary condition: false
initial concentration: 28.5
constant: false
initial amount: NaN
has only substance units: false
name: Smad2n

LRC surf
has only substance units: false
has part: P36897
initial amount: NaN
constant: false
type: Species
name: LRC_surf
is version of: GO:0043235
is: SBO:0000297
has part: P01137
has part: P37173
occurs in: GO:0009986
boundary condition: false
initial concentration: 0.0
substance units: nM
in compartment: Vcyt

CDMT00096
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

CDMT00104
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

CDMT00018
stoichiometry: 1.0
species: T2R endo
type: SpeciesReference

CDMT00028
stoichiometry: 1.0
species: T1R surf
type: SpeciesReference

PSmad2 PSmad2 n
initial amount: NaN
has only substance units: false
has part: Q15796
in compartment: Vnuc
initial concentration: 0.0
is version of: C00562
type: Species
constant: false
boundary condition: false
name: PSmad2_PSmad2_n
is: SBO:0000286
substance units: nM

klid
constant: true
units: per min
value: 0.0233678
type: Parameter

CDMT00081
stoichiometry: 2.0
species: PSmad2c
type: SpeciesReference

CDMT00138
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

totalNumT1R
constant: false
units: mol per cell
value: 10005.0
type: Parameter

CDMT00058
stoichiometry: 1.0
species: PSmad2c
type: SpeciesReference

CDMT00068
stoichiometry: 1.0
species: Smad4c
type: SpeciesReference

CDMT00124
persistant: true
initial value: true
type: Trigger

CDMT00091
stoichiometry: 1.0
species: TGF beta ns
type: SpeciesReference

CDMT00015
stoichiometry: 1.0
species: T2R surf
type: SpeciesReference

CDMT00042
stoichiometry: 1.0
species: LRC endo
type: SpeciesReference

single pulse duration
constant: true
units: min
value: 0.5
type: Parameter

CDMT00117
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

CDMT00029
stoichiometry: 1.0
species: LRC surf
type: SpeciesReference

CDMT00055
stoichiometry: 1.0
species: Smad4c
type: SpeciesReference

re8
kinetic law: CDMT00025
product: CDMT00024
reactant: CDMT00023
is version of: GO:0032801
fast: false
reversible: false
name: T2R constitutive degradation
type: Reaction

re20
kinetic law: CDMT00066
product: CDMT00065
reactant: CDMT00064
is version of: GO:0051169
fast: false
reversible: false
name: PSmad2 nuclear export
type: Reaction

CDMT00137
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

CDMT00094
stoichiometry: 1.0
species: empty degraded
type: SpeciesReference

CDMT00098
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

kdepho Smad2
constant: true
units: per min
value: 0.394
type: Parameter

CDMT00069
stoichiometry: 1.0
species: PSmad2 Smad4 c
type: SpeciesReference

kr
constant: true
units: per min
value: 0.0333
type: Parameter

volume
unit: CDMT00097
name: volume
type: SBMLUnitsDef

BIOMD0000000342
units def: volume
reaction: re19
reaction: re25
parameter: totalNumLRC
units def: time
parameter: kon Smads
parameter: kpho Smad2
units def: area
species: PSmad2 PSmad2 c
units def: length
event: single pulse stimulation
species: LRC surf
species: PSmad2 Smad4 c
rule: CDMT00109
parameter: kdepho Smad2
compartment: default
parameter: kdeg T1R
length unit: length
rule: CDMT00110
units def: third order
parameter: kimp Smads
reaction: re17
species: PSmad2c
parameter: koff Smads
reaction: re8
reaction: re9
parameter: k T2R
parameter: kdiss LRC
reaction: re2
reaction: re23
time units: time
substance units: substance
units def: nM per min
parameter: kdeg TGF beta
rule: CDMT00106
reaction: re22
reaction: re28
compartment: Vnuc
parameter: KD ns
parameter: kexp Smad4
compartment: Vmed
parameter: totalSmad2n
reaction: re10
parameter: stimulation type
reaction: re15
reaction: re16
parameter: totalSmad2c
parameter: kimp Smad4
reaction: re7
reaction: re6
parameter: kexp Smad2
species: AA
species: Smad4n
is: MODEL1104050000
reaction: re18
parameter: kdeg LRC
occurs in: http://identifiers.org/taxonomy/9606
parameter: kdeg T2R
rule: CDMT00112
rule: CDMT00115
type: SBMLModel
rule: CDMT00111
is described by: http://identifiers.org/pubmed/21613981
area units: area
species: Smad4c
parameter: totalNumPSmad2
species: TGF beta ex
species: T2R endo
species: LRC endo
parameter: k T1R
parameter: totalNumT1R
species: T2R surf
parameter: kr
species: PSmad2 Smad4 n
species: PSmad2 PSmad2 n
is part of: REACT 6844
species: TGF beta ns
reaction: re21
reaction: re1
rule: CDMT00107

re9
type: Reaction
reversible: false
kinetic law: CDMT00030
reactant: CDMT00028
reactant: CDMT00026
name: LRC activation
reactant: CDMT00027
fast: false
product: CDMT00029
is version of: GO:0005102

CDMT00136
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

CDMT00093
stoichiometry: 1.0
species: LRC surf
type: SpeciesReference

CDMT00097
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

kon Smads
constant: true
units: second order
value: 0.198472
type: Parameter

stimulation type
constant: true
units: dimensionless
value: 1.0
type: Parameter

Smad4c
name: Smad4c
in compartment: Vcyt
boundary condition: false
is: SBO:0000252
is version of: Q13485
type: Species
initial concentration: 50.8
initial amount: NaN
has only substance units: false
substance units: nM
constant: false

CDMT00101
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

re17
kinetic law: CDMT00056
product: CDMT00055
reactant: CDMT00054
is version of: GO:0051169
fast: false
reversible: false
name: Smad4 nuclear export
type: Reaction

Smad2c
name: Smad2c
boundary condition: false
type: Species
substance units: nM
initial concentration: 60.6
in compartment: Vcyt
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is version of: Q15796

re6
kinetic law: CDMT00019
product: CDMT00018
reactant: CDMT00017
is version of: GO:0031623
fast: false
reversible: false
name: T2R internalization to early endosome
type: Reaction

TGF beta ex
name: TGF_beta_ex
is version of: P01137
initial concentration: 0.05
initial amount: NaN
in compartment: Vmed
type: Species
occurs in: BTO:0000316
constant: false
is: SBO:0000252
substance units: nM
has only substance units: false
boundary condition: false

CDMT00114
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

CDMT00002
stoichiometry: 1.0
species: AA
type: SpeciesReference

Vcyt
is version of: GO:0005737
is: SBO:0000290
constant: true
units: volume
size: 2.3E-12
spatial dimensions: 3.0
name: Cytoplasm
type: Compartment

T1R endo
initial concentration: 6.52344
is: SBO:0000244
occurs in: GO:0005769
is version of: P36897
constant: false
name: T1R_endo
type: Species
in compartment: Vcyt
substance units: nM
initial amount: NaN
has only substance units: false
boundary condition: false

CDMT00099
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

KD ns
constant: true
units: dimensionless
value: 40.2257
type: Parameter

CDMT00100
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

re18
kinetic law: CDMT00060
modifier: CDMT00059
product: CDMT00058
reactant: CDMT00057
is version of: GO:0006468
fast: false
reversible: false
name: Smad2 phosphorylation
type: Reaction

per min
unit: CDMT00101
name: per min
type: SBMLUnitsDef

single pulse stimulation
event assignment: CDMT00128
delay: CDMT00125
trigger: CDMT00124
use values from trigger time: true
name: TGF-beta washout in singel pulse stimulation
type: Event

totalSmad2n
constant: false
units: nM
value: 28.5
type: Parameter

re7
kinetic law: CDMT00022
product: CDMT00021
reactant: CDMT00020
is version of: GO:0032456
fast: false
reversible: false
name: T2R recycling from early endosome
type: Reaction

kdeg T2R
constant: true
units: per min
value: 0.0132
type: Parameter

CDMT00113
exponent: -2.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

CDMT00079
stoichiometry: 1.0
species: Smad2n
type: SpeciesReference

kexp Smad2
constant: true
units: per min
value: 0.763
type: Parameter

length
unit: CDMT00099
name: length
type: SBMLUnitsDef

re29
kinetic law: CDMT00092
product: CDMT00091
reactant: CDMT00090
is version of: GO:0005102
fast: false
reversible: true
name: non-specific binding of TGF-beta
type: Reaction

CDMT00103
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

re19
kinetic law: CDMT00063
product: CDMT00062
reactant: CDMT00061
is version of: GO:0051169
fast: false
reversible: false
name: PSmad2 nuclear import
type: Reaction

CDMT00039
stoichiometry: 1.0
species: TGF beta endo
type: SpeciesReference

koff ns
constant: false
units: per min
value: 2.03306
type: Parameter

CDMT00090
stoichiometry: 1.0
species: TGF beta ex
type: SpeciesReference

re4
kinetic law: CDMT00013
product: CDMT00012
reactant: CDMT00011
is version of: GO:0032801
fast: false
reversible: false
name: T1R constitutive degradation
type: Reaction

PSmad2 Smad4 c
has part: Q15796
initial concentration: 0.0
is version of: C00562
constant: false
in compartment: Vcyt
substance units: nM
initial amount: NaN
type: Species
name: PSmad2_Smad4_c
boundary condition: false
has part: Q13485
is: SBO:0000297
has only substance units: false

CDMT00102
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

TGF beta endo
boundary condition: false
in compartment: Vcyt
has only substance units: false
type: Species
initial amount: NaN
is version of: P01137
occurs in: GO:0005769
substance units: nM
name: TGF_beta_endo
constant: false
initial concentration: 0.0
is: SBO:0000252

kdeg TGF beta
constant: true
units: per min
value: 0.347
type: Parameter

second order
unit: CDMT00137
unit: CDMT00136
name: second order rate constant
type: SBMLUnitsDef

re5
kinetic law: CDMT00016
product: CDMT00015
reactant: CDMT00014
is version of: GO:0032800
fast: false
reversible: false
name: T2R production
type: Reaction

kexp Smad4
constant: true
units: per min
value: 0.359
type: Parameter

kon ns
constant: true
units: per min
value: 0.0505413
type: Parameter

Vmed
is version of: BTO:0000316
is: SBO:0000290
constant: false
units: volume
size: 2.0E-9
spatial dimensions: 3.0
name: Medium
type: Compartment

CDMT00020
stoichiometry: 1.0
species: T2R endo
type: SpeciesReference

re27
kinetic law: CDMT00089
product: CDMT00088
reactant: CDMT00087
is version of: GO:0043241
fast: false
reversible: true
name: PSmad2 dimmer dissociation
type: Reaction

CDMT00048
stoichiometry: 1.0
species: Smad2n
type: SpeciesReference

TGF beta dose
constant: false
units: mol per cell
value: 0.0
type: Parameter

substance
unit: CDMT00096
name: substance
type: SBMLUnitsDef

PSmad2 Smad4 n
name: PSmad2_Smad4_n
is: SBO:0000297
initial concentration: 0.0
has only substance units: false
substance units: nM
constant: false
type: Species
has part: Q15796
has version: C00562
initial amount: NaN
boundary condition: false
has part: Q13485
in compartment: Vnuc

CDMT00087
stoichiometry: 1.0
species: PSmad2 PSmad2 n
type: SpeciesReference

re2
kinetic law: CDMT00007
product: CDMT00006
reactant: CDMT00005
is version of: GO:0031623
fast: false
reversible: false
name: T1R internalization to early endosome
type: Reaction

re13
kinetic law: CDMT00041
product: CDMT00040
reactant: CDMT00039
is version of: GO:0030163
fast: false
reversible: false
name: TGF-beta constitutive degradation
type: Reaction

Smad4n
is version of: Q13485
substance units: nM
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
name: Smad4n
in compartment: Vnuc
constant: false
initial concentration: 50.8
is: SBO:0000252

AA
is: SBO:0000291
in compartment: Vcyt
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: 0.0
type: Species
substance units: nM
constant: true
name: AA

CDMT00006
stoichiometry: 1.0
species: T1R endo
type: SpeciesReference

TGF beta ns
initial concentration: 0.0
has only substance units: false
in compartment: Vmed
name: TGF_beta_ns
constant: false
boundary condition: false
is version of: P01137
is: SBO:0000252
substance units: nM
type: Species
initial amount: NaN

ki
constant: true
units: per min
value: 0.333
type: Parameter

totalNuclearPSmad2
constant: false
units: nM
value: 0.0
type: Parameter

mol per cell
unit: CDMT00117
name: molecules per cell
type: SBMLUnitsDef

re3
kinetic law: CDMT00010
product: CDMT00009
reactant: CDMT00008
is version of: GO:0032456
fast: false
reversible: false
name: T1R recycling from early endosome
type: Reaction

re28
kinetic law: CDMT00095
product: CDMT00094
reactant: CDMT00093
is version of: GO:0009057
fast: false
reversible: false
name: negative feedback induced LRC degradation
type: Reaction

kimp Smads
constant: true
units: per min
value: 0.889
type: Parameter

CDMT00037
stoichiometry: 1.0
species: TGF beta endo
type: SpeciesReference

re14
kinetic law: CDMT00047
product: CDMT00046
reactant: CDMT00045
is version of: GO:0051169
fast: false
reversible: false
name: Smad2 nuclear import
type: Reaction

CDMT00088
stoichiometry: 2.0
species: PSmad2n
type: SpeciesReference

CDMT00005
stoichiometry: 1.0
species: T1R surf
type: SpeciesReference

CDMT00078
stoichiometry: 1.0
species: PSmad2n
type: SpeciesReference

kpho Smad2
constant: true
units: second order
value: 0.0488268
type: Parameter

re25
kinetic law: CDMT00083
product: CDMT00082
reactant: CDMT00081
is version of: GO:0006461
fast: false
reversible: true
name: PSmad2 dimer formation
type: Reaction

CDMT00075
stoichiometry: 1.0
species: PSmad2n
type: SpeciesReference

kdeg T1R
constant: true
units: per min
value: 0.00256
type: Parameter

CDMT00036
stoichiometry: 1.0
species: T2R endo
type: SpeciesReference

PSmad2c
initial concentration: 0.0
has only substance units: false
is version of: Q15796
boundary condition: false
is: SBO:0000252
name: PSmad2c
initial amount: NaN
is version of: C00562
type: Species
substance units: nM
in compartment: Vcyt
constant: false

LRC endo
has part: P01137
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
in compartment: Vcyt
name: LRC_endo
is version of: GO:0043235
initial concentration: 0.0
has part: P36897
constant: false
occurs in: GO:0005769
has part: P37173
is: SBO:0000297
substance units: nM

W3 CDTF: Thu Jul 14 13:23:21 BST 2011

re15
kinetic law: CDMT00050
product: CDMT00049
reactant: CDMT00048
is version of: GO:0051169
fast: false
reversible: false
name: Smad2 nuclear export
type: Reaction

CDMT00061
stoichiometry: 1.0
species: PSmad2c
type: SpeciesReference

medium TGF beta amount
constant: false
units: mol per cell
value: 0.0
type: Parameter

totalNumLRC
constant: false
units: mol per cell
value: 0.0
type: Parameter

CDMT00049
stoichiometry: 1.0
species: Smad2c
type: SpeciesReference

PSmad2 PSmad2 c
has part: Q15796
is: SBO:0000286
initial amount: NaN
boundary condition: false
has only substance units: false
name: PSmad2_PSmad2_c
in compartment: Vcyt
type: Species
initial concentration: 0.0
is version of: C00562
constant: false
substance units: nM

k T1R
constant: true
units: nM per min
value: 0.0167
type: Parameter

re26
kinetic law: CDMT00086
product: CDMT00085
reactant: CDMT00084
is version of: GO:0051169
fast: false
reversible: false
name: PSmad2 dimer nuclear import
type: Reaction

CDMT00021
stoichiometry: 1.0
species: T2R surf
type: SpeciesReference

CDMT00076
stoichiometry: 1.0
species: Smad4n
type: SpeciesReference

re1
kinetic law: CDMT00004
product: CDMT00003
reactant: CDMT00002
is version of: GO:0032800
fast: false
reversible: false
name: T1R production
type: Reaction

CDMT00035
stoichiometry: 1.0
species: T1R endo
type: SpeciesReference

re16
kinetic law: CDMT00053
product: CDMT00052
reactant: CDMT00051
is version of: GO:0051169
fast: false
reversible: false
name: Smad4 nuclear import
type: Reaction

k T2R
constant: true
units: nM per min
value: 0.0190076
type: Parameter

CDMT00062
stoichiometry: 1.0
species: PSmad2n
type: SpeciesReference

totalNumPSmad2
constant: false
units: mol per cell
value: 0.0
type: Parameter

CDMT00003
stoichiometry: 1.0
species: T1R surf
type: SpeciesReference

Vnuc
is version of: GO:0005634
is: SBO:0000290
constant: true
units: volume
size: 1.0E-12
spatial dimensions: 3.0
name: Nucleus
type: Compartment

T1R surf
occurs in: GO:0009986
in compartment: Vcyt
boundary condition: false
initial amount: NaN
substance units: nM
constant: false
is: SBO:0000244
name: T1R_surf
initial concentration: 0.702494
has only substance units: false
type: Species
is version of: P36897

kdeg LRC
constant: true
units: per min
value: 0.00256
type: Parameter

CDMT00034
stoichiometry: 1.0
species: LRC endo
type: SpeciesReference

koff Smads
constant: true
units: per min
value: 1.0
type: Parameter

re23
kinetic law: CDMT00077
product: CDMT00076
product: CDMT00075
reactant: CDMT00074
is version of: GO:0051169
fast: false
reversible: true
name: Smad2-Smad4 dissociation
type: Reaction

CDMT00024
stoichiometry: 1.0
species: empty degraded
type: SpeciesReference

kimp Smad2
constant: true
units: per min
value: 0.156
type: Parameter

CDMT00014
stoichiometry: 1.0
species: AA
type: SpeciesReference

CDMT00084
stoichiometry: 1.0
species: PSmad2 PSmad2 c
type: SpeciesReference

re10
kinetic law: CDMT00033
product: CDMT00032
reactant: CDMT00031
is version of: GO:0031623
fast: false
reversible: false
name: LRC internalization to early endosome
type: Reaction

CDMT00074
stoichiometry: 1.0
species: PSmad2 Smad4 n
type: SpeciesReference

re24
kinetic law: CDMT00080
product: CDMT00079
reactant: CDMT00078
is version of: GO:0006470
fast: false
reversible: false
name: Smad2 dephosphorylation
type: Reaction

nM
unit: CDMT00104
name: nanomolar
type: SBMLUnitsDef

T2R surf
boundary condition: false
is: SBO:0000244
name: T2R_surf
has only substance units: false
constant: false
occurs in: GO:0009986
initial amount: NaN
type: Species
initial concentration: 0.201077
is version of: P37173
in compartment: Vcyt
substance units: nM

time
unit: CDMT00100
name: min
type: SBMLUnitsDef

CDMT00023
stoichiometry: 1.0
species: T2R endo
type: SpeciesReference

CDMT00054
stoichiometry: 1.0
species: Smad4n
type: SpeciesReference

default
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
type: Compartment

CDMT00043
stoichiometry: 1.0
species: empty degraded
type: SpeciesReference

CDMT00009
stoichiometry: 1.0
species: T1R surf
type: SpeciesReference

ka LRC
constant: true
units: third order
value: 117.897
type: Parameter

third order
unit: CDMT00114
unit: CDMT00113
name: third order rate constant
type: SBMLUnitsDef

CDMT00064
stoichiometry: 1.0
species: PSmad2n
type: SpeciesReference

re11
kinetic law: CDMT00044
product: CDMT00043
reactant: CDMT00042
is version of: GO:0032801
fast: false
reversible: false
name: LRC constitutive degradation
type: Reaction

CDMT00085
stoichiometry: 1.0
species: PSmad2 PSmad2 n
type: SpeciesReference

CDMT00071
stoichiometry: 1.0
species: PSmad2 Smad4 c
type: SpeciesReference

kdiss LRC
constant: true
units: per min
value: 0.0438111
type: Parameter

CDMT00046
stoichiometry: 1.0
species: Smad2n
type: SpeciesReference

re21
kinetic law: CDMT00070
product: CDMT00069
reactant: CDMT00068
reactant: CDMT00067
is version of: GO:0006461
fast: false
reversible: true
name: Smad2-Smad4 complex formation
type: Reaction

totalNumT2R
constant: false
units: mol per cell
value: 2272.0
type: Parameter

PSmad2n
constant: false
initial amount: NaN
has only substance units: false
is version of: C00562
initial concentration: 0.0
name: PSmad2n
is: SBO:0000252
substance units: nM
type: Species
boundary condition: false
in compartment: Vnuc
is version of: Q15796

CDMT00026
stoichiometry: 1.0
species: TGF beta ex
type: SpeciesReference

kimp Smad4
constant: true
units: per min
value: 0.156
type: Parameter

totalSmad2c
constant: false
units: nM
value: 60.6
type: Parameter

CDMT00051
stoichiometry: 1.0
species: Smad4c
type: SpeciesReference

CDMT00065
stoichiometry: 1.0
species: PSmad2c
type: SpeciesReference

nM per min
unit: CDMT00103
unit: CDMT00102
name: nM per min
type: SBMLUnitsDef

CDMT00012
stoichiometry: 1.0
species: empty degraded
type: SpeciesReference

CDMT00008
stoichiometry: 1.0
species: T1R endo
type: SpeciesReference

CDMT00032
stoichiometry: 1.0
species: LRC endo
type: SpeciesReference

area
unit: CDMT00098
name: area
type: SBMLUnitsDef

re12
product: CDMT00037
name: dissociation of LRC in endosome
product: CDMT00035
reversible: false
is version of: GO:0043241
product: CDMT00036
type: Reaction
kinetic law: CDMT00038
reactant: CDMT00034
fast: false

T2R endo
is: SBO:0000244
type: Species
in compartment: Vcyt
name: T2R_endo
initial concentration: 1.43997
has only substance units: false
constant: false
is version of: P37173
substance units: nM
boundary condition: false
encodes: GO:0005769
initial amount: NaN

CDMT00072
stoichiometry: 1.0
species: PSmad2 Smad4 n
type: SpeciesReference

empty degraded
initial concentration: 0.0
has only substance units: false
boundary condition: true
type: Species
in compartment: Vcyt
name: empty_degraded
constant: true
substance units: nM
is: SBO:0000291
initial amount: NaN

CDMT00045
stoichiometry: 1.0
species: Smad2c
type: SpeciesReference

re22
kinetic law: CDMT00073
product: CDMT00072
reactant: CDMT00071
fast: false
reversible: false
name: Smad2-Smad4 nuclear import
type: Reaction

CDMT00052
stoichiometry: 1.0
species: Smad4n
type: SpeciesReference

CDMT00011
stoichiometry: 1.0
species: T1R endo
type: SpeciesReference

CDMT00031
stoichiometry: 1.0
species: LRC surf
type: SpeciesReference

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

W3 CDTF: Fri Jun 07 16:42:26 BST 2013

given: Zhike
family: Zi

ORG:
  orgname: BIOSS Centre for Biological Signalling Studies, University of Freiburg