187916
is: SBO:0000010
stoichiometry: 1.0
species: 6
type: SpeciesReference

161
kinetic law: 190582
product: 190570
fast: false
reversible: false
name: pV
type: Reaction

175
constant: true
value: 89.6
name: IX(0)
type: Parameter

8
is: P03951
constant: false
boundary condition: false
has only substance units: false
initial concentration: 30.6
initial amount: NaN
in compartment: 229
name: XI
type: Species

207
is: SBO:0000035
constant: true
value: 20.0
name: d_TFPI
type: Parameter

54
is: CHEBI:28384
constant: false
boundary condition: false
has only substance units: false
initial concentration: 115.4754
initial amount: NaN
in compartment: 229
name: VK_p
type: Species

186826
is: SBO:0000010
stoichiometry: 1.0
species: 5
type: SpeciesReference

44
is version of: CHEBI:28384
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 229
name: VKO
type: Species

217
constant: true
value: 2.5
name: TFPI(0)
type: Parameter

190450
is: SBO:0000010
stoichiometry: 1.0
species: 51
type: SpeciesReference

104
kinetic law: 189090
modifier: 189078
product: 189066
fast: false
reversible: false
name: pVII_VKH2
type: Reaction

057921
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

190838
persistant: true
initial value: true
type: Trigger

195
constant: true
value: 1.0
name: warfarin_ka
type: Parameter

188595
is: SBO:0000010
stoichiometry: 1.0
species: 10
type: SpeciesReference

181
is: SBO:0000035
constant: true
value: 0.12
name: d_VII
type: Parameter

189210
is: SBO:0000011
stoichiometry: 1.0
species: 34
type: SpeciesReference

189993
is: SBO:0000010
stoichiometry: 1.0
species: 33
type: SpeciesReference

55
kinetic law: 186777
modifier: 186765
product: 186752
reactant: 186740
fast: false
reversible: false
name: r1
type: Reaction

208
is: SBO:0000035
constant: true
value: 0.05
name: d_Pk
type: Parameter

7
is version of: P03951
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: XIa
type: Species

160
kinetic law: 190558
product: 190546
fast: false
reversible: false
name: pXI
type: Reaction

187251
is: SBO:0000010
stoichiometry: 1.0
species: 17
type: SpeciesReference

190161
is: SBO:0000010
stoichiometry: 1.0
species: 26
type: SpeciesReference

174
constant: true
value: 10.0
name: VII(0)
type: Parameter

45
is: P03952
constant: false
boundary condition: false
has only substance units: false
initial concentration: 450.0
initial amount: NaN
in compartment: 229
name: Pk
type: Species

218
constant: true
value: 450.0
name: Pk(0)
type: Parameter

105
kinetic law: 189126
modifier: 189114
product: 189102
fast: false
reversible: false
name: pIX_VKH2
type: Reaction

057920
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

194
is: SBO:0000035
constant: true
value: 0.693
name: heparin_ke
type: Parameter

180
is: SBO:0000035
constant: true
value: 0.01
name: d_II
type: Parameter

189873
is: SBO:0000010
stoichiometry: 1.0
species: 27
type: SpeciesReference

190342
is: SBO:0000010
stoichiometry: 1.0
species: 42
type: SpeciesReference

163
kinetic law: 190630
product: 190618
fast: false
reversible: false
name: pXIII
type: Reaction

205
is: SBO:0000035
constant: true
value: 0.05
name: d_Pg
type: Parameter

56
kinetic law: 186814
modifier: 186802
reactant: 186790
fast: false
reversible: false
name: r2
type: Reaction

106
kinetic law: 189162
modifier: 189150
product: 189138
fast: false
reversible: false
name: pX_VKH2
type: Reaction

219
constant: true
value: 0.140845070422535
name: R1
type: Parameter

186838
is: SBO:0000011
stoichiometry: 1.0
species: 6
type: SpeciesReference

173
constant: true
value: 1394.4
name: II(0)
type: Parameter

18
boundary condition: false
has part: P02671
has part: P02675
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: F
in compartment: 229
initial concentration: 0.0
has part: P02679

42
is: CHEBI:28384
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 229
name: VK
type: Species

187928
is: SBO:0000010
stoichiometry: 1.0
species: 3
type: SpeciesReference

190763
is: SBO:0000010
stoichiometry: 1.0
species: 42
type: SpeciesReference

193
is: SBO:0000035
constant: true
value: 0.0587
name: vitaminK_k12
type: Parameter

187880
is: SBO:0000010
stoichiometry: 1.0
species: 36
type: SpeciesReference

189584
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

188811
is: SBO:0000011
stoichiometry: 1.0
species: 51
type: SpeciesReference

183
is: SBO:0000035
constant: true
value: 0.018
name: d_X
type: Parameter

190137
is: SBO:0000010
stoichiometry: 1.0
species: 28
type: SpeciesReference

57
kinetic law: 186862
modifier: 186850
product: 186838
reactant: 186826
fast: false
reversible: false
name: r3
type: Reaction

206
is: SBO:0000035
constant: true
value: 0.05
name: d_Tmod
type: Parameter

9
is version of: P00748
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: XIIa
type: Species

162
kinetic law: 190606
product: 190594
fast: false
reversible: false
name: pFg
type: Reaction

19
initial amount: NaN
type: Species
constant: false
name: Fg
has part: P02679
has only substance units: false
initial concentration: 8945.5
boundary condition: false
in compartment: 229
has part: P02675
has part: P02671

172
constant: true
value: 0.34
name: IC50
type: Parameter

189801
is: SBO:0000010
stoichiometry: 1.0
species: 39
type: SpeciesReference

107
kinetic law: 189198
modifier: 189186
product: 189174
fast: false
reversible: false
name: pPC_VKH2
type: Reaction

187263
is: SBO:0000011
stoichiometry: 1.0
species: 1
type: SpeciesReference

43
is: CHEBI:10033
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: C_warf
type: Species

188499
is: SBO:0000010
stoichiometry: 1.0
species: 10
type: SpeciesReference

189705
is: SBO:0000010
stoichiometry: 1.0
species: 9
type: SpeciesReference

188511
is: SBO:0000011
stoichiometry: 1.0
species: 11
type: SpeciesReference

192
is: SBO:0000038
constant: true
value: 5.08333333333333E-4
name: vitaminK_k21/Vc
type: Parameter

182
is: SBO:0000035
constant: true
value: 0.029
name: d_IX
type: Parameter

40
has part: P01008
constant: false
has only substance units: false
in compartment: 229
name: ATIII_Heparin
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 0.0
has part: CHEBI:28304

189066
is: SBO:0000011
stoichiometry: 1.0
species: 10
type: SpeciesReference

171
constant: true
value: 1.0
name: I_max
type: Parameter

188415
is: SBO:0000011
stoichiometry: 1.0
species: 30
type: SpeciesReference

188691
is: SBO:0000010
stoichiometry: 1.0
species: 38
type: SpeciesReference

50
has version: P00488
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: XIIIa
type: Species

188847
is: SBO:0000010
stoichiometry: 1.0
species: 40
type: SpeciesReference

185
is: SBO:0000035
constant: true
value: 0.0165
name: d_PS
type: Parameter

199
is: SBO:0000035
constant: true
value: 0.012
name: d_XII
type: Parameter

30
has part: P13726
has only substance units: false
constant: false
in compartment: 229
initial amount: NaN
name: VIIa_TF
has part: P08709
type: Species
initial concentration: 0.0
boundary condition: false

190402
is: SBO:0000010
stoichiometry: 1.0
species: 41
type: SpeciesReference

188367
is: SBO:0000011
stoichiometry: 1.0
species: 6
type: SpeciesReference

20
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: DP
type: Species

100
kinetic law: 188920
product: 188907
reactant: 188895
reactant: 188883
fast: false
reversible: false
name: r46
type: Reaction

190354
is: SBO:0000011
stoichiometry: 1.0
species: 54
type: SpeciesReference

41
constant: false
boundary condition: false
has only substance units: false
in compartment: 229
name: Xa_ATIII_Heparin
type: Species
initial concentration: 0.0
initial amount: NaN
has part: CHEBI:28304
has part: P01008
has part: P00742

170
kinetic law: 190800
product: 190787
fast: false
reversible: false
name: pHeparin
type: Reaction

187832
is: SBO:0000010
stoichiometry: 1.0
species: 27
type: SpeciesReference

190813
persistant: true
initial value: true
type: Trigger

190114
is: SBO:0000010
stoichiometry: 1.0
species: 14
type: SpeciesReference

51
initial amount: NaN
in compartment: 229
name: IIa_ATIII_Heparin
boundary condition: false
has only substance units: false
constant: false
type: Species
has part: P00734
initial concentration: 0.0
has part: CHEBI:28304
has part: P01008

184
is: SBO:0000035
constant: true
value: 0.05
name: d_PC
type: Parameter

198
constant: true
value: 0.02
name: warfarin_ke
type: Parameter

31
in compartment: 229
initial concentration: 0.0
initial amount: NaN
has part: P08709
boundary condition: false
has part: P13726
type: Species
has only substance units: false
constant: false
name: VII_TF

187543
is: SBO:0000010
stoichiometry: 1.0
species: 22
type: SpeciesReference

101
kinetic law: 188969
modifier: 188956
product: 188944
reactant: 188932
fast: false
reversible: false
name: r47
type: Reaction

188895
is: SBO:0000010
stoichiometry: 1.0
species: 40
type: SpeciesReference

187348
is: SBO:0000010
stoichiometry: 1.0
species: 19
type: SpeciesReference

187748
is: SBO:0000011
stoichiometry: 1.0
species: 21
type: SpeciesReference

21
is version of: P00747
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: P
type: Species

189560
is: SBO:0000010
stoichiometry: 1.0
species: 3
type: SpeciesReference

188835
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

209
constant: true
value: 375.0
name: XII(0)
type: Parameter

52
boundary condition: false
initial amount: NaN
name: IXa_ATIII_Heparin
has part: P00740
initial concentration: 0.0
constant: false
has part: CHEBI:28304
in compartment: 229
has part: P01008
type: Species
has only substance units: false

189258
is: SBO:0000011
stoichiometry: 1.0
species: 46
type: SpeciesReference

190186
is: SBO:0000010
stoichiometry: 1.0
species: 32
type: SpeciesReference

197
constant: true
value: 0.2
name: warfarin_CL
type: Parameter

32
in compartment: 229
type: Species
initial amount: NaN
constant: false
has part: P00742
boundary condition: false
has part: P10646
name: Xa_TFPI
has only substance units: false
initial concentration: 0.0

229
constant: true
size: 1.0
spatial dimensions: 3.0
name: compartment_1
type: Compartment

187
constant: true
value: 0.0228
name: d_VK2
type: Parameter

057889
is: SBO:0000036
value: 0.01
name: c
type: LocalParameter

189897
is: SBO:0000010
stoichiometry: 1.0
species: 25
type: SpeciesReference

102
kinetic law: 189017
modifier: 189005
product: 188993
reactant: 188981
fast: false
reversible: false
name: r48
type: Reaction

187844
is: SBO:0000011
stoichiometry: 1.0
species: 25
type: SpeciesReference

189729
is: SBO:0000010
stoichiometry: 1.0
species: 23
type: SpeciesReference

53
is: CHEBI:10033
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: A_warf
type: Species

187555
is: SBO:0000011
stoichiometry: 1.0
species: 47
type: SpeciesReference

33
is: P10646
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.5
initial amount: NaN
in compartment: 229
name: TFPI
type: Species

196
constant: true
value: 10.0
name: warfarin_Vd
type: Parameter

189825
is: SBO:0000010
stoichiometry: 1.0
species: 24
type: SpeciesReference

189246
is: SBO:0000010
stoichiometry: 1.0
species: 19
type: SpeciesReference

186
constant: true
value: 24.0
name: vitaminK_Vc
type: Parameter

103
kinetic law: 189054
modifier: 189041
product: 189029
fast: false
reversible: false
name: pII_VKH2
type: Reaction

057878
is: SBO:0000371
value: 5000.0
name: k
type: LocalParameter

188012
is: SBO:0000010
stoichiometry: 1.0
species: 1
type: SpeciesReference

189
constant: true
value: 0.228
name: d_VKO
type: Parameter

115
kinetic law: 189451
reactant: 189438
fast: false
reversible: false
name: dV
type: Reaction

24
is: P00747
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2154.3
initial amount: NaN
in compartment: 229
name: Pg
type: Species

34
is: P07225
constant: false
boundary condition: false
has only substance units: false
initial concentration: 300.0
initial amount: NaN
in compartment: 229
name: PS
type: Species

227
constant: true
value: 0.0
name: heparin_bolus
type: Parameter

125
kinetic law: 189693
reactant: 189681
fast: false
reversible: false
name: dXII
type: Reaction

057868
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

057915
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

057972
is: SBO:0000035
value: 0.05
name: k1
type: LocalParameter

057848
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

058001
is: SBO:0000035
value: 0.1
name: k1
type: LocalParameter

65
kinetic law: 187239
modifier: 187227
reactant: 187215
fast: false
reversible: false
name: r11
type: Reaction

057901
is: SBO:0000025
value: 900.0
name: v
type: LocalParameter

169
kinetic law: 190775
reactant: 190763
fast: false
reversible: false
name: dVK
type: Reaction

237
event assignment: 190851
trigger: 190838
use values from trigger time: true
name: heparin_administration
type: Event

057858
is: SBO:0000025
value: 9.0
name: v
type: LocalParameter

75
kinetic law: 187724
modifier: 187712
product: 187700
reactant: 187688
fast: false
reversible: false
name: r21
type: Reaction

188643
is: SBO:0000010
stoichiometry: 1.0
species: 38
type: SpeciesReference

188306
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

187652
is: SBO:0000011
stoichiometry: 1.0
species: 50
type: SpeciesReference

058012
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

188703
is: SBO:0000011
stoichiometry: 1.0
species: 9
type: SpeciesReference

210
constant: true
value: 0.7
name: VIII(0)
type: Parameter

114
kinetic law: 189426
reactant: 189414
fast: false
reversible: false
name: dTF
type: Reaction

057877
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

188
is: SBO:0000035
constant: true
value: 0.228
name: d_VKH2
type: Parameter

25
is version of: P04070
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: APC
type: Species

124
kinetic law: 189669
reactant: 189657
fast: false
reversible: false
name: dIXa
type: Reaction

057993
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

200
is: SBO:0000035
constant: true
value: 0.058
name: d_VIII
type: Parameter

228
constant: true
value: 24.0
name: heparin_infusion_duration [hr]
type: Parameter

35
is version of: CHEBI:28384
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 229
name: VKH2
type: Species

058022
is: SBO:0000035
value: 0.1
name: k1
type: LocalParameter

057914
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

190498
is: SBO:0000011
stoichiometry: 1.0
species: 38
type: SpeciesReference

057867
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

64
kinetic law: 187203
modifier: 187191
product: 187179
reactant: 187166
fast: false
reversible: false
name: r10
type: Reaction

057847
is: SBO:0000025
value: 1.0E-9
name: v
type: LocalParameter

188993
is: SBO:0000011
stoichiometry: 1.0
species: 42
type: SpeciesReference

168
kinetic law: 190751
product: 190739
fast: false
reversible: false
name: pVK
type: Reaction

057900
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

057983
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

190714
is: SBO:0000011
stoichiometry: 1.0
species: 45
type: SpeciesReference

057973
is: SBO:0000035
value: 0.05
name: k1
type: LocalParameter

74
kinetic law: 187676
modifier: 187664
product: 187652
reactant: 187640
fast: false
reversible: false
name: r20
type: Reaction

36
has part: P00742
has part: P12259
constant: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
has only substance units: false
type: Species
name: Va_Xa
boundary condition: false

113
kinetic law: 189402
product: 189390
reactant: 189378
fast: false
reversible: false
name: dIIa
type: Reaction

22
initial amount: NaN
type: Species
constant: false
has only substance units: false
in compartment: 229
name: XF
has part: P02679
boundary condition: false
initial concentration: 0.0
has part: P02671
has part: P02675

211
constant: true
value: 30.6
name: XI(0)
type: Parameter

188161
is: SBO:0000010
stoichiometry: 1.0
species: 30
type: SpeciesReference

188883
is: SBO:0000010
stoichiometry: 1.0
species: 6
type: SpeciesReference

127
kinetic law: 189741
reactant: 189729
fast: false
reversible: false
name: dXIII
type: Reaction

057866
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

057846
is: SBO:0000371
value: 0.1
name: k
type: LocalParameter

225
constant: true
value: 4.0
name: warfarin_daily_dose
type: Parameter

058003
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

63
kinetic law: 187154
modifier: 187142
product: 187130
reactant: 187117
fast: false
reversible: false
name: r9
type: Reaction

188318
is: SBO:0000011
stoichiometry: 1.0
species: 13
type: SpeciesReference

189849
is: SBO:0000010
stoichiometry: 1.0
species: 21
type: SpeciesReference

187736
is: SBO:0000010
stoichiometry: 1.0
species: 24
type: SpeciesReference

77
kinetic law: 187820
modifier: 187808
product: 187796
reactant: 187784
fast: false
reversible: false
name: r23
type: Reaction

37
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: CA
type: Species

23
name: XIII
initial amount: NaN
has part: P05160
type: Species
constant: false
boundary condition: false
has part: P00488
has only substance units: false
in compartment: 229
initial concentration: 70.3

187130
is: SBO:0000011
stoichiometry: 1.0
species: 13
type: SpeciesReference

212
constant: true
value: 26.7
name: V(0)
type: Parameter

112
kinetic law: 189366
reactant: 189354
fast: false
reversible: false
name: dII
type: Reaction

057879
is: SBO:0000025
value: 5.0
name: v
type: LocalParameter

058010
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

189753
is: SBO:0000010
stoichiometry: 1.0
species: 50
type: SpeciesReference

057865
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

188025
is: SBO:0000010
stoichiometry: 1.0
species: 28
type: SpeciesReference

057991
is: SBO:0000035
value: 0.69
name: k1
type: LocalParameter

126
kinetic law: 189717
reactant: 189705
fast: false
reversible: false
name: dXIIa
type: Reaction

226
is: SBO:0000048
constant: false
value: 0.0
name: heparin_infusion
type: Parameter

188981
is: SBO:0000010
stoichiometry: 1.0
species: 44
type: SpeciesReference

057845
is: SBO:0000025
value: 2.0
name: v
type: LocalParameter

62
kinetic law: 187105
modifier: 187093
product: 187081
reactant: 187068
fast: false
reversible: false
name: r8
type: Reaction

058004
is: SBO:0000035
value: 0.7
name: k1
type: LocalParameter

057916
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

057985
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

190017
is: SBO:0000010
stoichiometry: 1.0
species: 30
type: SpeciesReference

76
kinetic law: 187772
modifier: 187760
product: 187748
reactant: 187736
fast: false
reversible: false
name: r22
type: Reaction

189174
is: SBO:0000011
stoichiometry: 1.0
species: 27
type: SpeciesReference

28
is: P07204
constant: false
boundary condition: false
has only substance units: false
initial concentration: 50.0
initial amount: NaN
in compartment: 229
name: Tmod
type: Species

188907
is: SBO:0000011
stoichiometry: 1.0
species: 52
type: SpeciesReference

187700
is: SBO:0000011
stoichiometry: 1.0
species: 21
type: SpeciesReference

057911
is: SBO:0000025
value: 1.0
name: v
type: LocalParameter

89
kinetic law: 188391
modifier: 188379
product: 188367
reactant: 188355
fast: false
reversible: false
name: r35
type: Reaction

203
is: SBO:0000035
constant: true
value: 0.032
name: d_Fg
type: Parameter

213
constant: true
value: 8945.5
name: Fg(0)
type: Parameter

139
kinetic law: 190029
reactant: 190017
fast: false
reversible: false
name: dVIIa_TF
type: Reaction

99
kinetic law: 188871
product: 188859
reactant: 188847
reactant: 188835
fast: false
reversible: false
name: r45
type: Reaction

057905
is: SBO:0000025
value: 1000.0
name: v
type: LocalParameter

38
is: P00748
constant: false
boundary condition: false
has only substance units: false
initial concentration: 375.0
initial amount: NaN
in compartment: 229
name: XII
type: Species

79
kinetic law: 187904
modifier: 187892
reactant: 187880
fast: false
reversible: false
name: r25
type: Reaction

119
kinetic law: 189548
reactant: 189536
fast: false
reversible: false
name: dVIII
type: Reaction

190041
is: SBO:0000010
stoichiometry: 1.0
species: 31
type: SpeciesReference

69
kinetic law: 187433
modifier: 187421
product: 187409
reactant: 187397
fast: false
reversible: false
name: r15
type: Reaction

108
kinetic law: 189234
modifier: 189222
product: 189210
fast: false
reversible: false
name: pPS_VKH2
type: Reaction

58
kinetic law: 186911
modifier: 186899
product: 186886
reactant: 186874
fast: false
reversible: false
name: r4
type: Reaction

057854
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

165
kinetic law: 190678
product: 190666
fast: false
reversible: false
name: pTmod
type: Reaction

186935
is: SBO:0000011
stoichiometry: 1.0
species: 7
type: SpeciesReference

149
kinetic law: 190270
reactant: 190258
fast: false
reversible: false
name: dCA
type: Reaction

189102
is: SBO:0000011
stoichiometry: 1.0
species: 5
type: SpeciesReference

057844
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

48
type: Species
name: TAT
initial amount: NaN
in compartment: 229
initial concentration: 0.0
boundary condition: false
has only substance units: false
has part: P00734
has part: P01008
constant: false

223
is: SBO:0000036
constant: true
value: 0.85
name: c46
type: Parameter

188173
is: SBO:0000010
stoichiometry: 1.0
species: 32
type: SpeciesReference

129
kinetic law: 189789
reactant: 189777
fast: false
reversible: false
name: dPk
type: Reaction

179
constant: true
value: 0.1
name: VKH2(0)
type: Parameter

057910
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

190474
is: SBO:0000010
stoichiometry: 1.0
species: 8
type: SpeciesReference

204
is: SBO:0000035
constant: true
value: 0.0036
name: d_XIII
type: Parameter

88
kinetic law: 188343
modifier: 188330
product: 188318
reactant: 188306
fast: false
reversible: false
name: r34
type: Reaction

29
is: P13726
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: TF
type: Species

190618
is: SBO:0000011
stoichiometry: 1.0
species: 23
type: SpeciesReference

98
kinetic law: 188823
product: 188811
reactant: 188799
reactant: 188787
fast: false
reversible: false
name: r44
type: Reaction

214
constant: true
value: 70.3
name: XIII(0)
type: Parameter

058016
is: SBO:0000035
value: 0.05
name: k1
type: LocalParameter

057997
is: SBO:0000035
value: 20.4
name: k1
type: LocalParameter

39
is version of: P03952
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: K
type: Species

057904
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

118
kinetic law: 189524
reactant: 189511
fast: false
reversible: false
name: dVIIa
type: Reaction

78
kinetic law: 187868
modifier: 187856
product: 187844
reactant: 187832
fast: false
reversible: false
name: r24
type: Reaction

186752
is: SBO:0000011
stoichiometry: 1.0
species: 3
type: SpeciesReference

164
kinetic law: 190654
product: 190642
fast: false
reversible: false
name: pPg
type: Reaction

59
kinetic law: 186959
modifier: 186947
product: 186935
reactant: 186923
fast: false
reversible: false
name: r5
type: Reaction

138
kinetic law: 190005
reactant: 189993
fast: false
reversible: false
name: dTFPI
type: Reaction

109
kinetic law: 189270
product: 189258
reactant: 189246
fast: false
reversible: false
name: dFg
type: Reaction

057853
is: SBO:0000025
value: 50.0
name: v
type: LocalParameter

057843
is: SBO:0000025
value: 0.02
name: v
type: LocalParameter

49
has only substance units: false
has part: P00742
type: Species
initial concentration: 0.0
initial amount: NaN
has part: P13726
boundary condition: false
has part: P08709
has part: P10646
name: VIIa_TF_Xa_TFPI
in compartment: 229
constant: false

189414
is: SBO:0000010
stoichiometry: 1.0
species: 29
type: SpeciesReference

148
kinetic law: 190246
reactant: 190234
fast: false
reversible: false
name: dTAT
type: Reaction

178
constant: true
value: 300.0
name: PS(0)
type: Parameter

188037
is: SBO:0000011
stoichiometry: 1.0
species: 26
type: SpeciesReference

188607
is: SBO:0000011
stoichiometry: 1.0
species: 11
type: SpeciesReference

128
kinetic law: 189765
reactant: 189753
fast: false
reversible: false
name: dXIIIa
type: Reaction

68
kinetic law: 187385
modifier: 187373
product: 187361
reactant: 187348
fast: false
reversible: false
name: r14
type: Reaction

224
is: SBO:0000035
constant: true
value: 0.2052
name: d_VK
type: Parameter

201
constant: true
value: 0.1
name: d_XI
type: Parameter

87
kinetic law: 188294
modifier: 188281
product: 188269
reactant: 188257
fast: false
reversible: false
name: r33
type: Reaction

057913
is: SBO:0000025
value: 0.2
name: v
type: LocalParameter

188655
is: SBO:0000011
stoichiometry: 1.0
species: 9
type: SpeciesReference

26
initial concentration: 0.0
has only substance units: false
has part: P00734
in compartment: 229
type: Species
name: IIa_Tmod
constant: false
boundary condition: false
initial amount: NaN
has part: P07204

058013
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

188221
is: SBO:0000010
stoichiometry: 1.0
species: 33
type: SpeciesReference

215
constant: true
value: 2154.3
name: Pg(0)
type: Parameter

187068
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

167
kinetic law: 190726
product: 190714
fast: false
reversible: false
name: pPk
type: Reaction

46
boundary condition: false
has only substance units: false
has part: P02671
has part: P02675
constant: false
initial concentration: 0.0
name: FDP
initial amount: NaN
type: Species
in compartment: 229
has part: P02679

137
kinetic law: 189981
reactant: 189969
fast: false
reversible: false
name: dD
type: Reaction

057856
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

188185
is: SBO:0000011
stoichiometry: 1.0
species: 49
type: SpeciesReference

117
kinetic law: 189499
reactant: 189487
fast: false
reversible: false
name: dVII
type: Reaction

057903
is: SBO:0000025
value: 70.0
name: v
type: LocalParameter

67
kinetic law: 187336
modifier: 187324
product: 187312
reactant: 187299
fast: false
reversible: false
name: r13
type: Reaction

177
constant: true
value: 60.0
name: PC(0)
type: Parameter

057842
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

221
is: SBO:0000036
constant: true
value: 0.119718309859155
name: c44
type: Parameter

202
is: SBO:0000035
constant: true
value: 0.043
name: d_V
type: Parameter

057912
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

190787
is: SBO:0000011
stoichiometry: 1.0
species: 40
type: SpeciesReference

86
kinetic law: 188245
product: 188233
reactant: 188221
reactant: 188209
fast: false
reversible: false
name: r32
type: Reaction

27
is: P04070
constant: false
boundary condition: false
has only substance units: false
initial concentration: 60.0
initial amount: NaN
in compartment: 229
name: PC
type: Species

057995
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

058014
is: SBO:0000035
value: 0.2
name: k1
type: LocalParameter

116
kinetic law: 189475
reactant: 189463
fast: false
reversible: false
name: dVa
type: Reaction

057922
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

136
kinetic law: 189957
reactant: 189945
fast: false
reversible: false
name: dFDP
type: Reaction

057855
is: SBO:0000025
value: 100.0
name: v
type: LocalParameter

166
kinetic law: 190702
product: 190690
fast: false
reversible: false
name: pTFPI
type: Reaction

216
constant: true
value: 50.0
name: Tmod(0)
type: Parameter

057981
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

057902
is: SBO:0000371
value: 200.0
name: k
type: LocalParameter

236
event assignment: 190826
trigger: 190813
use values from trigger time: true
name: warfarin_administration
type: Event

186740
is: SBO:0000010
stoichiometry: 1.0
species: 2
type: SpeciesReference

186692
unit: 186704
name: time
type: SBMLUnitsDef

66
kinetic law: 187287
modifier: 187275
product: 187263
reactant: 187251
fast: false
reversible: false
name: r12
type: Reaction

189777
is: SBO:0000010
stoichiometry: 1.0
species: 45
type: SpeciesReference

187688
is: SBO:0000010
stoichiometry: 1.0
species: 24
type: SpeciesReference

47
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: D
type: Species

222
is: SBO:0000036
constant: true
value: 0.85
name: c45
type: Parameter

187031
is: SBO:0000011
stoichiometry: 1.0
species: 13
type: SpeciesReference

176
constant: true
value: 174.3
name: X(0)
type: Parameter

057841
is: SBO:0000025
value: 0.1
name: v
type: LocalParameter

156
kinetic law: 190462
reactant: 190450
fast: false
reversible: false
name: eHeparinIIa
type: Reaction

057835
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

146
kinetic law: 190198
reactant: 190186
fast: false
reversible: false
name: dXa_TFPI
type: Reaction

187796
is: SBO:0000011
stoichiometry: 1.0
species: 21
type: SpeciesReference

96
kinetic law: 188727
modifier: 188715
product: 188703
reactant: 188691
fast: false
reversible: false
name: r42
type: Reaction

058008
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

057880
is: SBO:0000371
value: 10000.0
name: k
type: LocalParameter

186923
is: SBO:0000010
stoichiometry: 1.0
species: 8
type: SpeciesReference

190666
is: SBO:0000011
stoichiometry: 1.0
species: 28
type: SpeciesReference

157
kinetic law: 190486
reactant: 190474
fast: false
reversible: false
name: dXI
type: Reaction

057850
is: SBO:0000025
value: 50000.0
name: v
type: LocalParameter

188062
is: SBO:0000010
stoichiometry: 1.0
species: 11
type: SpeciesReference

057836
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

057840
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

189330
is: SBO:0000011
stoichiometry: 1.0
species: 47
type: SpeciesReference

147
kinetic law: 190222
reactant: 190210
fast: false
reversible: false
name: dVIIa_TF_Xa_TFPI
type: Reaction

058017
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

057860
is: SBO:0000371
value: 500.0
name: k
type: LocalParameter

189029
is: SBO:0000011
stoichiometry: 1.0
species: 17
type: SpeciesReference

057870
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

190594
is: SBO:0000011
stoichiometry: 1.0
species: 19
type: SpeciesReference

190690
is: SBO:0000011
stoichiometry: 1.0
species: 33
type: SpeciesReference

058007
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

97
kinetic law: 188775
modifier: 188763
product: 188751
reactant: 188739
fast: false
reversible: false
name: r43
type: Reaction

187603
is: SBO:0000011
stoichiometry: 1.0
species: 47
type: SpeciesReference

158
kinetic law: 190510
product: 190498
fast: false
reversible: false
name: pXII
type: Reaction

93
kinetic law: 188583
modifier: 188571
product: 188559
reactant: 188547
fast: false
reversible: false
name: r39
type: Reaction

144
kinetic law: 190149
reactant: 190137
fast: false
reversible: false
name: dTmod
type: Reaction

057979
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

187166
is: SBO:0000010
stoichiometry: 1.0
species: 15
type: SpeciesReference

057833
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

188075
is: SBO:0000010
stoichiometry: 1.0
species: 29
type: SpeciesReference

189438
is: SBO:0000010
stoichiometry: 1.0
species: 15
type: SpeciesReference

057892
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

130
kinetic law: 189813
reactant: 189801
fast: false
reversible: false
name: dK
type: Reaction

057999
is: SBO:0000035
value: 3.5
name: k1
type: LocalParameter

187117
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

187507
is: SBO:0000011
stoichiometry: 1.0
species: 46
type: SpeciesReference

94
kinetic law: 188631
modifier: 188619
product: 188607
reactant: 188595
fast: false
reversible: false
name: r40
type: Reaction

189969
is: SBO:0000010
stoichiometry: 1.0
species: 47
type: SpeciesReference

187784
is: SBO:0000010
stoichiometry: 1.0
species: 24
type: SpeciesReference

159
kinetic law: 190534
product: 190522
fast: false
reversible: false
name: pVIII
type: Reaction

190739
is: SBO:0000011
stoichiometry: 1.0
species: 42
type: SpeciesReference

190065
is: SBO:0000010
stoichiometry: 1.0
species: 4
type: SpeciesReference

187179
is: SBO:0000011
stoichiometry: 1.0
species: 16
type: SpeciesReference

145
kinetic law: 190174
reactant: 190161
fast: false
reversible: false
name: dIIa_Tmod
type: Reaction

057834
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

057852
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

189390
is: SBO:0000011
stoichiometry: 1.0
species: 48
type: SpeciesReference

189681
is: SBO:0000010
stoichiometry: 1.0
species: 38
type: SpeciesReference

80
kinetic law: 187952
product: 187940
reactant: 187928
reactant: 187916
fast: false
reversible: false
name: r26
type: Reaction

188233
is: SBO:0000011
stoichiometry: 1.0
species: 32
type: SpeciesReference

058005
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

057891
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

057872
is: SBO:0000371
value: 100.0
name: k
type: LocalParameter

187446
is: SBO:0000010
stoichiometry: 1.0
species: 18
type: SpeciesReference

95
kinetic law: 188679
modifier: 188667
product: 188655
reactant: 188643
fast: false
reversible: false
name: r41
type: Reaction

189536
is: SBO:0000010
stoichiometry: 1.0
species: 2
type: SpeciesReference

131
kinetic law: 189837
reactant: 189825
fast: false
reversible: false
name: dPg
type: Reaction

186728
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

057831
is: SBO:0000025
value: 50.0
name: v
type: LocalParameter

152
kinetic law: 190366
product: 190354
reactant: 190342
fast: false
reversible: true
name: VK_transport
type: Reaction

057977
is: SBO:0000035
value: 0.05
name: k1
type: LocalParameter

186874
is: SBO:0000010
stoichiometry: 1.0
species: 8
type: SpeciesReference

188739
is: SBO:0000010
stoichiometry: 1.0
species: 45
type: SpeciesReference

142
kinetic law: 190102
reactant: 190089
fast: false
reversible: false
name: dVa_Xa
type: Reaction

189633
is: SBO:0000010
stoichiometry: 1.0
species: 5
type: SpeciesReference

91
kinetic law: 188487
product: 188475
reactant: 188463
reactant: 188451
fast: false
reversible: false
name: r37
type: Reaction

72
kinetic law: 187579
modifier: 187567
product: 187555
reactant: 187543
fast: false
reversible: false
name: r18
type: Reaction

057987
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

057906
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

71
kinetic law: 187531
modifier: 187519
product: 187507
reactant: 187495
fast: false
reversible: false
name: r17
type: Reaction

132
kinetic law: 189861
reactant: 189849
fast: false
reversible: false
name: dP
type: Reaction

188932
is: SBO:0000010
stoichiometry: 1.0
species: 42
type: SpeciesReference

187640
is: SBO:0000010
stoichiometry: 1.0
species: 23
type: SpeciesReference

057863
is: SBO:0000025
value: 500.0
name: v
type: LocalParameter

189487
is: SBO:0000010
stoichiometry: 1.0
species: 10
type: SpeciesReference

057873
is: SBO:0000025
value: 1.0
name: v
type: LocalParameter

188087
is: SBO:0000011
stoichiometry: 1.0
species: 30
type: SpeciesReference

122
kinetic law: 189621
reactant: 189609
fast: false
reversible: false
name: dXa
type: Reaction

81
kinetic law: 188000
product: 187988
reactant: 187976
reactant: 187964
fast: false
reversible: false
name: r27
type: Reaction

057976
is: SBO:0000035
value: 67.4
name: k1
type: LocalParameter

83
kinetic law: 188099
product: 188087
reactant: 188075
reactant: 188062
fast: false
reversible: false
name: r29
type: Reaction

BIOMD0000000340
reaction: 112
parameter: 201
species: 54
parameter: 179
reaction: 75
reaction: 72
species: 26
parameter: 216
name: Irreversible association
parameter: 197
parameter: 213
reaction: 121
species: 1
species: 42
reaction: 128
reaction: 55
function def: 230
reaction: 107
reaction: 170
species: 12
reaction: 84
reaction: 89
parameter: 208
parameter: 220
reaction: 108
parameter: 189
species: 30
reaction: 138
reaction: 150
parameter: 209
reaction: 167
parameter: 191
reaction: 130
reaction: 168
name: Warfarin inhibited first order kinetics
reaction: 147
parameter: 223
parameter: 205
is described by: http://identifiers.org/pubmed/19516255
reaction: 65
parameter: 183
function def: 231
reaction: 114
reaction: 164
parameter: 203
reaction: 91
reaction: 143
parameter: 184
reaction: 98
parameter: 217
reaction: 77
rule: 240
species: 47
reaction: 144
species: 28
notes: This model is from the article: A comprehensive model for the humoral coagulation network in humans. Wajima T, Isbister GK, Duffull SB. Clinical Pharmacology and therapeutics Volume 86, Issue 3, 10 June 2009, EPub 19516255 , Abstract: Coagulation is an important process in hemostasis and comprises a complicated interaction of multiple enzymes and proteins. We have developed a mechanistic quantitative model of the coagulation network. The model accurately describes the time courses of coagulation factors following in vivo activation as well as in vitro blood coagulation tests of prothrombin time (PT, often reported as international normalized ratio (INR)) and activated partial thromboplastin time (aPTT). The model predicts the concentration-time and time-effect profiles of warfarin, heparins, and vitamin K in humans. The model can be applied to predict the time courses of coagulation kinetics in clinical situations (e.g., hemophilia) and for biomarker identification during drug development. The model developed in this study is the first quantitative description of the comprehensive coagulation network.
reaction: 71
reaction: 123
reaction: 78
parameter: 199
parameter: 215
parameter: 196
units def: 186716
species: 3
species: 44
reaction: 57
parameter: 180
species: 14
name: Factor production
species: 35
reaction: 156
species: 51
species: 32
parameter: 211
reaction: 74
parameter: 192
parameter: 228
species: 23
reaction: 120
parameter: 175

143
kinetic law: 190125
reactant: 190114
fast: false
reversible: false
name: dIXa_VIIIa
type: Reaction

188269
is: SBO:0000011
stoichiometry: 1.0
species: 30
type: SpeciesReference

057832
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

187458
is: SBO:0000011
stoichiometry: 1.0
species: 22
type: SpeciesReference

153
kinetic law: 190390
reactant: 190378
fast: false
reversible: false
name: eHeparin
type: Reaction

92
kinetic law: 188535
modifier: 188523
product: 188511
reactant: 188499
fast: false
reversible: false
name: r38
type: Reaction

73
kinetic law: 187628
modifier: 187616
product: 187603
reactant: 187591
fast: false
reversible: false
name: r19
type: Reaction

190642
is: SBO:0000011
stoichiometry: 1.0
species: 24
type: SpeciesReference

133
kinetic law: 189885
reactant: 189873
fast: false
reversible: false
name: dPC
type: Reaction

057864
is: SBO:0000371
value: 500.0
name: k
type: LocalParameter

188799
is: SBO:0000010
stoichiometry: 1.0
species: 40
type: SpeciesReference

057874
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

187409
is: SBO:0000011
stoichiometry: 1.0
species: 46
type: SpeciesReference

82
kinetic law: 188049
product: 188037
reactant: 188025
reactant: 188012
fast: false
reversible: false
name: r28
type: Reaction

123
kinetic law: 189645
reactant: 189633
fast: false
reversible: false
name: dIX
type: Reaction

057918
is: SBO:0000025
value: 70.0
name: v
type: LocalParameter

84
kinetic law: 188147
product: 188135
reactant: 188123
reactant: 188111
fast: false
reversible: false
name: r30
type: Reaction

186886
is: SBO:0000011
stoichiometry: 1.0
species: 7
type: SpeciesReference

057989
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

057908
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

140
kinetic law: 190053
reactant: 190041
fast: false
reversible: false
name: dVII_TF
type: Reaction

186716
unit: 186728
name: substance
type: SBMLUnitsDef

154
kinetic law: 190414
reactant: 190402
fast: false
reversible: false
name: eHeparinXa
type: Reaction

134
kinetic law: 189909
reactant: 189897
fast: false
reversible: false
name: dAPC
type: Reaction

120
kinetic law: 189572
reactant: 189560
fast: false
reversible: false
name: dVIIIa
type: Reaction

057875
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

220
constant: true
value: 1.0
name: R2
type: Parameter

057861
is: SBO:0000025
value: 20000.0
name: v
type: LocalParameter

057830
is: SBO:0000371
value: 1.0E-6
name: k
type: LocalParameter

85
kinetic law: 188197
product: 188185
reactant: 188173
reactant: 188161
fast: false
reversible: false
name: r31
type: Reaction

186971
is: SBO:0000010
stoichiometry: 1.0
species: 10
type: SpeciesReference

187361
is: SBO:0000011
stoichiometry: 1.0
species: 18
type: SpeciesReference

90
kinetic law: 188439
modifier: 188427
product: 188415
reactant: 188403
fast: false
reversible: false
name: r36
type: Reaction

188257
is: SBO:0000010
stoichiometry: 1.0
species: 31
type: SpeciesReference

141
kinetic law: 190077
reactant: 190065
fast: false
reversible: false
name: dAPC_PS
type: Reaction

057909
is: SBO:0000025
value: 1.0
name: v
type: LocalParameter

155
kinetic law: 190438
reactant: 190426
fast: false
reversible: false
name: eHeparinIXa
type: Reaction

135
kinetic law: 189933
reactant: 189921
fast: false
reversible: false
name: dPS
type: Reaction

190089
is: SBO:0000010
stoichiometry: 1.0
species: 36
type: SpeciesReference

70
kinetic law: 187483
modifier: 187471
product: 187458
reactant: 187446
fast: false
reversible: false
name: r16
type: Reaction

121
kinetic law: 189596
reactant: 189584
fast: false
reversible: false
name: dX
type: Reaction

057862
is: SBO:0000371
value: 0.5
name: k
type: LocalParameter

057876
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

188787
is: SBO:0000010
stoichiometry: 1.0
species: 1
type: SpeciesReference

190378
is: SBO:0000010
stoichiometry: 1.0
species: 40
type: SpeciesReference

1
is version of: P00734
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: IIa
type: Species

190546
is: SBO:0000011
stoichiometry: 1.0
species: 8
type: SpeciesReference

188451
is: SBO:0000010
stoichiometry: 1.0
species: 25
type: SpeciesReference

057888
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

057898
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

057829
is: SBO:0000025
value: 50000.0
name: v
type: LocalParameter

190318
is: SBO:0000011
stoichiometry: 1.0
species: 44
type: SpeciesReference

189378
is: SBO:0000010
stoichiometry: 1.0
species: 1
type: SpeciesReference

13
is version of: P00742
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: Xa
type: Species

188111
is: SBO:0000010
stoichiometry: 1.0
species: 10
type: SpeciesReference

187312
is: SBO:0000011
stoichiometry: 1.0
species: 1
type: SpeciesReference

187397
is: SBO:0000010
stoichiometry: 1.0
species: 19
type: SpeciesReference

186983
is: SBO:0000011
stoichiometry: 1.0
species: 11
type: SpeciesReference

2
is: P00451
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.7
initial amount: NaN
in compartment: 229
name: VIII
type: Species

187988
is: SBO:0000011
stoichiometry: 1.0
species: 36
type: SpeciesReference

057887
is: SBO:0000025
value: 2.0
name: v
type: LocalParameter

189463
is: SBO:0000010
stoichiometry: 1.0
species: 16
type: SpeciesReference

188859
is: SBO:0000011
stoichiometry: 1.0
species: 41
type: SpeciesReference

189318
is: SBO:0000010
stoichiometry: 1.0
species: 22
type: SpeciesReference

188355
is: SBO:0000010
stoichiometry: 1.0
species: 5
type: SpeciesReference

12
is: P00742
constant: false
boundary condition: false
has only substance units: false
initial concentration: 174.3
initial amount: NaN
in compartment: 229
name: X
type: Species

186704
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

187940
is: SBO:0000011
stoichiometry: 1.0
species: 14
type: SpeciesReference

189657
is: SBO:0000010
stoichiometry: 1.0
species: 6
type: SpeciesReference

187299
is: SBO:0000010
stoichiometry: 1.0
species: 17
type: SpeciesReference

057886
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

111
kinetic law: 189342
product: 189330
reactant: 189318
fast: false
reversible: false
name: dXF
type: Reaction

188463
is: SBO:0000010
stoichiometry: 1.0
species: 34
type: SpeciesReference

60
kinetic law: 187007
modifier: 186995
product: 186983
reactant: 186971
fast: false
reversible: false
name: r6
type: Reaction

61
kinetic law: 187056
modifier: 187043
product: 187031
reactant: 187019
fast: false
reversible: false
name: r7
type: Reaction

11
is version of: P08709
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: VIIa
type: Species

150
kinetic law: 190294
reactant: 190282
fast: false
reversible: false
name: dXIa
type: Reaction

057885
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

110
kinetic law: 189306
product: 189294
reactant: 189282
fast: false
reversible: false
name: dF
type: Reaction

188944
is: SBO:0000011
stoichiometry: 1.0
species: 35
type: SpeciesReference

190426
is: SBO:0000010
stoichiometry: 1.0
species: 52
type: SpeciesReference

057899
is: SBO:0000025
value: 70.0
name: v
type: LocalParameter

10
is: P08709
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 229
name: VII
type: Species

190282
is: SBO:0000010
stoichiometry: 1.0
species: 7
type: SpeciesReference

187591
is: SBO:0000010
stoichiometry: 1.0
species: 22
type: SpeciesReference

151
kinetic law: 190330
product: 190318
reactant: 190306
fast: false
reversible: false
name: dVKH2
type: Reaction

189921
is: SBO:0000010
stoichiometry: 1.0
species: 34
type: SpeciesReference

190210
is: SBO:0000010
stoichiometry: 1.0
species: 49
type: SpeciesReference

057884
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

188135
is: SBO:0000011
stoichiometry: 1.0
species: 31
type: SpeciesReference

190570
is: SBO:0000011
stoichiometry: 1.0
species: 15
type: SpeciesReference

190
constant: true
value: 1.0
name: VK(0)
type: Parameter

5
is: P00740
constant: false
boundary condition: false
has only substance units: false
initial concentration: 89.6
initial amount: NaN
in compartment: 229
name: IX
type: Species

189609
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

188475
is: SBO:0000011
stoichiometry: 1.0
species: 4
type: SpeciesReference

188559
is: SBO:0000011
stoichiometry: 1.0
species: 11
type: SpeciesReference

17
is: P00734
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1394.4
initial amount: NaN
in compartment: 229
name: II
type: Species

190522
is: SBO:0000011
stoichiometry: 1.0
species: 2
type: SpeciesReference

188751
is: SBO:0000011
stoichiometry: 1.0
species: 39
type: SpeciesReference

187019
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

190258
is: SBO:0000010
stoichiometry: 1.0
species: 37
type: SpeciesReference

189354
is: SBO:0000010
stoichiometry: 1.0
species: 17
type: SpeciesReference

187215
is: SBO:0000010
stoichiometry: 1.0
species: 16
type: SpeciesReference

189138
is: SBO:0000011
stoichiometry: 1.0
species: 12
type: SpeciesReference

186790
is: SBO:0000010
stoichiometry: 1.0
species: 3
type: SpeciesReference

057893
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

6
is version of: P00740
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: IXa
type: Species

191
constant: true
value: 0.1
name: VKO(0)
type: Parameter

187964
is: SBO:0000010
stoichiometry: 1.0
species: 16
type: SpeciesReference

16
is version of: P12259
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: Va
type: Species

189294
is: SBO:0000011
stoichiometry: 1.0
species: 46
type: SpeciesReference

188403
is: SBO:0000010
stoichiometry: 1.0
species: 31
type: SpeciesReference

057882
is: SBO:0000025
value: 2.0
name: v
type: LocalParameter

187495
is: SBO:0000010
stoichiometry: 1.0
species: 18
type: SpeciesReference

057896
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

3
is version of: P00451
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 229
name: VIIIa
type: Species

189282
is: SBO:0000010
stoichiometry: 1.0
species: 18
type: SpeciesReference

188123
is: SBO:0000010
stoichiometry: 1.0
species: 29
type: SpeciesReference

15
is: P12259
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.7
initial amount: NaN
in compartment: 229
name: V
type: Species

190306
is: SBO:0000010
stoichiometry: 1.0
species: 35
type: SpeciesReference

187081
is: SBO:0000011
stoichiometry: 1.0
species: 13
type: SpeciesReference

W3 CDTF: Tue Jul 05 18:07:40 BST 2011

188547
is: SBO:0000010
stoichiometry: 1.0
species: 10
type: SpeciesReference

057838
is: SBO:0000025
value: 10.0
name: v
type: LocalParameter

057895
is: SBO:0000036
value: 0.1
name: c
type: LocalParameter

189511
is: SBO:0000010
stoichiometry: 1.0
species: 11
type: SpeciesReference

4
has part: P07225
in compartment: 229
has part: P04070
constant: false
name: APC_PS
type: Species
initial amount: NaN
initial concentration: 0.0
boundary condition: false
has only substance units: false

189945
is: SBO:0000010
stoichiometry: 1.0
species: 46
type: SpeciesReference

14
initial amount: NaN
name: IXa_VIIIa
in compartment: 229
initial concentration: 0.0
has part: P00740
has only substance units: false
boundary condition: false
type: Species
constant: false
has part: P00451

190234
is: SBO:0000010
stoichiometry: 1.0
species: 48
type: SpeciesReference

W3 CDTF: Fri Apr 20 22:45:50 BST 2012

187976
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

188209
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

given: Michael
family: Schubert

ORG:
  orgname: EBI