071700
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type: SpeciesReference

072784
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species: 8
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91
kinetic law: 070794
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reactant: 070770
reactant: 070758
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070578
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070254
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072615
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species: 35
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110
kinetic law: 071616
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7
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071604
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type: SpeciesReference

072422
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species: 14
type: SpeciesReference

070819
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species: 11
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071894
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species: 12
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90
kinetic law: 070746
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072374
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species: 4
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070050
is: SBO:0000010
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species: 24
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072062
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species: 50
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6
is version of: P00740
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072446
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species: 28
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070566
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species: 31
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072712
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species: 41
type: SpeciesReference

071797
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species: 10
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10
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initial concentration: 10.0
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209
constant: true
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161
kinetic law: 072893
product: 072881
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reversible: false
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071109
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30
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5
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070242
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978595
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072627
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069482
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11
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069809
is: SBO:0000010
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species: 18
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208
is: SBO:0000035
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160
kinetic law: 072869
product: 072857
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reversible: false
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31
name: VII_TF
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070758
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069299
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species: 11
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4
type: Species
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initial concentration: 0.0
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boundary condition: false
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070230
is: SBO:0000010
stoichiometry: 1.0
species: 6
type: SpeciesReference

207
is: SBO:0000035
constant: true
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name: d_TFPI
type: Parameter

071688
is: SBO:0000010
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species: 1
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069568
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species: 17
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978617
is: SBO:0000371
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name: k
type: LocalParameter

071242
is: SBO:0000010
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species: 42
type: SpeciesReference

071628
is: SBO:0000010
stoichiometry: 1.0
species: 22
type: SpeciesReference

22
type: Species
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has only substance units: false
has part: P02675
boundary condition: false
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constant: false

978597
is: SBO:0000025
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name: v
type: LocalParameter

072760
is: SBO:0000010
stoichiometry: 1.0
species: 51
type: SpeciesReference

069616
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stoichiometry: 1.0
species: 17
type: SpeciesReference

32
type: Species
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has part: P00742
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initial amount: NaN
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069287
is: SBO:0000010
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species: 10
type: SpeciesReference

206
is: SBO:0000035
constant: true
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name: d_Tmod
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978657
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

071918
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

070856
is: SBO:0000010
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species: 10
type: SpeciesReference

978618
is: SBO:0000025
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name: v
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070110
is: SBO:0000011
stoichiometry: 1.0
species: 21
type: SpeciesReference

978596
is: SBO:0000371
value: 1.0E-6
name: k
type: LocalParameter

23
boundary condition: false
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initial amount: NaN
initial concentration: 70.3
has only substance units: false
has part: P05160
in compartment: 226
name: XIII
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type: Species

978699
is: SBO:0000371
value: 1.0
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type: LocalParameter

070952
is: SBO:0000010
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species: 38
type: SpeciesReference

071870
is: SBO:0000010
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species: 3
type: SpeciesReference

072350
is: SBO:0000010
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species: 31
type: SpeciesReference

33
is: P10646
constant: false
boundary condition: false
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initial concentration: 2.5
initial amount: NaN
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name: TFPI
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49
has only substance units: false
initial concentration: 0.0
initial amount: NaN
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has part: P00742
boundary condition: false
has part: P08709
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978629
is: SBO:0000371
value: 0.5
name: k
type: LocalParameter

071254
is: SBO:0000011
stoichiometry: 1.0
species: 35
type: SpeciesReference

069006
unit: 069018
name: time
type: SBMLUnitsDef

205
is: SBO:0000035
constant: true
value: 0.05
name: d_Pg
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978619
is: SBO:0000371
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type: LocalParameter

072736
is: SBO:0000010
stoichiometry: 1.0
species: 53
type: SpeciesReference

20
constant: false
boundary condition: true
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initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: DP
type: Species

978698
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

071773
is: SBO:0000010
stoichiometry: 1.0
species: 16
type: SpeciesReference

070806
is: SBO:0000010
stoichiometry: 1.0
species: 10
type: SpeciesReference

978599
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

34
is: P07225
constant: false
boundary condition: false
has only substance units: false
initial concentration: 300.0
initial amount: NaN
in compartment: 226
name: PS
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9
is version of: P00748
constant: false
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has only substance units: false
initial concentration: 0.0
initial amount: NaN
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name: XIIa
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070062
is: SBO:0000011
stoichiometry: 1.0
species: 21
type: SpeciesReference

48
has only substance units: false
boundary condition: false
has part: P01008
initial amount: NaN
constant: false
type: Species
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name: TAT
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initial concentration: 0.0

978659
is: SBO:0000371
value: 1.0
name: k
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35
is version of: CHEBI:28384
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
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name: VKH2
type: Species

073001
is: SBO:0000011
stoichiometry: 1.0
species: 33
type: SpeciesReference

204
is: SBO:0000035
constant: true
value: 0.0036
name: d_XIII
type: Parameter

978669
is: SBO:0000036
value: 0.1
name: c
type: LocalParameter

070868
is: SBO:0000011
stoichiometry: 1.0
species: 11
type: SpeciesReference

978697
is: SBO:0000371
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name: k
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21
is version of: P00747
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
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name: P
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978598
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

8
is: P03951
constant: false
boundary condition: false
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initial concentration: 10.3734
initial amount: NaN
in compartment: 226
name: XI
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16
is version of: P12259
constant: false
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has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: Va
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070470
is: SBO:0000010
stoichiometry: 1.0
species: 30
type: SpeciesReference

978627
is: SBO:0000025
value: 20000.0
name: v
type: LocalParameter

072833
is: SBO:0000011
stoichiometry: 1.0
species: 2
type: SpeciesReference

118
kinetic law: 071834
reactant: 071821
fast: false
reversible: false
name: dVIIa
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072905
is: SBO:0000011
stoichiometry: 1.0
species: 19
type: SpeciesReference

978696
is: SBO:0000025
value: 70.0
name: v
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104
kinetic law: 071399
modifier: 071387
product: 071375
fast: false
reversible: false
name: pVII_VKH2
type: Reaction

071170
is: SBO:0000011
stoichiometry: 1.0
species: 41
type: SpeciesReference

072302
is: SBO:0000010
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species: 33
type: SpeciesReference

978613
is: SBO:0000371
value: 0.1
name: k
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216
constant: true
value: 50.0
name: Tmod(0)
type: Parameter

57
kinetic law: 069179
modifier: 069166
product: 069153
reactant: 069141
fast: false
reversible: false
name: r3
type: Reaction

978633
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

26
initial concentration: 0.0
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constant: false
type: Species
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initial amount: NaN
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name: IIa_Tmod
has part: P07204
boundary condition: false

77
kinetic law: 070134
modifier: 070122
product: 070110
reactant: 070098
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85
kinetic law: 070506
product: 070494
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reactant: 070470
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069677
is: SBO:0000011
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species: 18
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978647
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67
kinetic law: 069653
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reversible: false
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36
has only substance units: false
has part: P12259
has part: P00742
name: Va_Xa
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type: Species
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boundary condition: false

99
kinetic law: 071182
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reactant: 071158
reactant: 071145
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reversible: false
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196
constant: true
value: 0.2
name: Warfarin_CL
type: Parameter

070098
is: SBO:0000010
stoichiometry: 1.0
species: 24
type: SpeciesReference

47
constant: false
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has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: D
type: Species

198
constant: false
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name: Integral_Fibrin
type: Parameter

070530
is: SBO:0000010
stoichiometry: 1.0
species: 33
type: SpeciesReference

072808
is: SBO:0000011
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species: 38
type: SpeciesReference

103
kinetic law: 071363
modifier: 071351
product: 071339
fast: false
reversible: false
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type: Reaction

978695
is: SBO:0000371
value: 1.0
name: k
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17
is: P00734
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boundary condition: false
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initial concentration: 1394.4
initial amount: NaN
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name: II
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978752
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name: k1
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117
kinetic law: 071809
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56
kinetic law: 069129
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reversible: false
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978614
is: SBO:0000025
value: 1.0E-9
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76
kinetic law: 070086
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84
kinetic law: 070458
product: 070446
reactant: 070434
reactant: 070422
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27
is: P04070
constant: false
boundary condition: false
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initial concentration: 60.0
initial amount: NaN
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name: PC
type: Species

978648
is: SBO:0000025
value: 7.0
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37
constant: false
boundary condition: false
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initial concentration: 0.0
initial amount: NaN
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name: CA
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66
kinetic law: 069604
modifier: 069592
product: 069580
reactant: 069568
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46
has only substance units: false
initial amount: NaN
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type: Species
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boundary condition: false
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initial concentration: 0.0
has part: P02671
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217
constant: true
value: 2.5
name: TFPI(0)
type: Parameter

98
kinetic law: 071133
product: 071121
reactant: 071109
reactant: 071097
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reversible: false
name: r44
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197
constant: true
value: 0.02
name: Warfarin_ke
type: Parameter

069018
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

069203
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stoichiometry: 1.0
species: 7
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978694
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name: v
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106
kinetic law: 071472
modifier: 071460
product: 071448
fast: false
reversible: false
name: pX_VKH2
type: Reaction

18
type: Species
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boundary condition: false
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45
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boundary condition: false
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initial concentration: 450.0
initial amount: NaN
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name: Pk
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978625
is: SBO:0000371
value: 500.0
name: k
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978615
is: SBO:0000371
value: 10.0
name: k
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180
is: SBO:0000035
constant: true
value: 0.12
name: d_VII
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072254
is: SBO:0000010
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species: 46
type: SpeciesReference

116
kinetic law: 071785
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071411
is: SBO:0000011
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species: 5
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79
kinetic law: 070218
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978635
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070710
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species: 31
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24
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initial concentration: 2154.3
initial amount: NaN
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name: Pg
type: Species

59
kinetic law: 069275
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87
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070146
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stoichiometry: 1.0
species: 27
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978645
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97
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modifier: 071073
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218
constant: true
value: 450.0
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type: Parameter

194
constant: true
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name: Warfarin_ka
type: Parameter

069251
is: SBO:0000011
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species: 7
type: SpeciesReference

38
is: P00748
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initial concentration: 375.0
initial amount: NaN
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name: XII
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071592
is: SBO:0000010
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species: 18
type: SpeciesReference

65
kinetic law: 069555
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978750
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105
kinetic law: 071436
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product: 071411
fast: false
reversible: false
name: pIX_VKH2
type: Reaction

19
initial amount: NaN
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069628
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species: 1
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071846
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species: 2
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44
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initial concentration: 0.1
initial amount: NaN
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name: VKO
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978616
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181
is: SBO:0000035
constant: true
value: 0.029
name: d_IX
type: Parameter

978740
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value: 3.5
name: k1
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115
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reversible: false
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069821
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stoichiometry: 1.0
species: 46
type: SpeciesReference

25
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initial concentration: 0.0
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name: APC
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978636
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78
kinetic law: 070182
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86
kinetic law: 070554
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reactant: 070518
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58
kinetic law: 069227
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39
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initial concentration: 0.0
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name: K
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195
constant: true
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name: Warfarin_Vd
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219
constant: true
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name: R1
type: Parameter

64
kinetic law: 069519
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reactant: 069482
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96
kinetic law: 071037
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3
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initial concentration: 0.0
initial amount: NaN
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name: VIIIa
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070158
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species: 25
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114
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071375
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stoichiometry: 1.0
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182
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constant: true
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name: d_X
type: Parameter

53
has part: CHEBI:28304
type: Species
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name: IXa_ATIII_Heparin
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 0.0
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boundary condition: false
has part: P00740

071206
is: SBO:0000010
stoichiometry: 1.0
species: 40
type: SpeciesReference

978692
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

100
kinetic law: 071230
product: 071218
reactant: 071206
reactant: 071194
fast: false
reversible: false
name: r46
type: Reaction

43
is: CHEBI:10033
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: C_warf
type: Species

069153
is: SBO:0000011
stoichiometry: 1.0
species: 6
type: SpeciesReference

070722
is: SBO:0000011
stoichiometry: 1.0
species: 30
type: SpeciesReference

978623
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

172
constant: true
value: 1394.4
name: II(0)
type: Parameter

81
kinetic law: 070314
product: 070302
reactant: 070290
reactant: 070278
fast: false
reversible: false
name: r27
type: Reaction

192
is: SBO:0000035
constant: true
value: 0.0587
name: VitaminK_k12
type: Parameter

95
kinetic law: 070988
modifier: 070976
product: 070964
reactant: 070952
fast: false
reversible: false
name: r41
type: Reaction

072857
is: SBO:0000011
stoichiometry: 1.0
species: 8
type: SpeciesReference

12
is: P00742
constant: false
boundary condition: false
has only substance units: false
initial concentration: 174.3
initial amount: NaN
in compartment: 226
name: X
type: Species

978637
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

183
is: SBO:0000035
constant: true
value: 0.05
name: d_PC
type: Parameter

978610
is: SBO:0000025
value: 0.02
name: v
type: LocalParameter

2
is: P00451
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.7
initial amount: NaN
in compartment: 226
name: VIII
type: Species

52
is: CHEBI:10033
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: A_warf
type: Species

071568
is: SBO:0000011
stoichiometry: 1.0
species: 46
type: SpeciesReference

113
kinetic law: 071712
product: 071700
reactant: 071688
fast: false
reversible: false
name: dIIa
type: Reaction

13
is version of: P00742
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: Xa
type: Species

42
is: CHEBI:28384
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 226
name: VK
type: Species

978691
is: SBO:0000025
value: 0.2
name: v
type: LocalParameter

978624
is: SBO:0000025
value: 9.0
name: v
type: LocalParameter

173
constant: true
value: 10.0
name: VII(0)
type: Parameter

070278
is: SBO:0000010
stoichiometry: 1.0
species: 16
type: SpeciesReference

94
kinetic law: 070940
modifier: 070928
product: 070916
reactant: 070904
fast: false
reversible: false
name: r40
type: Reaction

069773
is: SBO:0000011
stoichiometry: 1.0
species: 22
type: SpeciesReference

193
is: SBO:0000035
constant: true
value: 0.693
name: Heparin_ke
type: Parameter

80
kinetic law: 070266
product: 070254
reactant: 070242
reactant: 070230
fast: false
reversible: false
name: r26
type: Reaction

55
kinetic law: 069093
modifier: 069080
product: 069068
reactant: 069055
fast: false
reversible: false
name: r1
type: Reaction

112
kinetic law: 071676
reactant: 071664
fast: false
reversible: false
name: dII
type: Reaction

978639
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

072518
is: SBO:0000010
stoichiometry: 1.0
species: 49
type: SpeciesReference

1
is version of: P00734
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: IIa
type: Species

184
is: SBO:0000035
constant: true
value: 0.0165
name: d_PS
type: Parameter

978611
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

069141
is: SBO:0000010
stoichiometry: 1.0
species: 5
type: SpeciesReference

978621
is: SBO:0000025
value: 100.0
name: v
type: LocalParameter

41
has part: P00742
has part: P01008
initial concentration: 0.0
initial amount: NaN
has only substance units: false
name: Xa_ATIII_Heparin
boundary condition: false
type: Species
constant: false
in compartment: 226
has part: CHEBI:28304

072182
is: SBO:0000010
stoichiometry: 1.0
species: 27
type: SpeciesReference

69
kinetic law: 069749
modifier: 069737
product: 069725
reactant: 069713
fast: false
reversible: false
name: r15
type: Reaction

070194
is: SBO:0000010
stoichiometry: 1.0
species: 36
type: SpeciesReference

102
kinetic law: 071327
modifier: 071315
product: 071303
reactant: 071290
fast: false
reversible: false
name: r48
type: Reaction

978690
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

170
constant: true
value: 1.0
name: I_max
type: Parameter

071218
is: SBO:0000011
stoichiometry: 1.0
species: 53
type: SpeciesReference

14
name: IXa_VIIIa
in compartment: 226
initial amount: NaN
initial concentration: 0.0
constant: false
boundary condition: false
has only substance units: false
has part: P00740
has part: P00451
type: Species

071821
is: SBO:0000010
stoichiometry: 1.0
species: 11
type: SpeciesReference

978765
is: SBO:0000035
value: 0.1
name: k1
type: LocalParameter

073121
persistant: true
initial value: true
type: Trigger

190
constant: true
value: 0.1
name: VKO(0)
type: Parameter

072881
is: SBO:0000011
stoichiometry: 1.0
species: 15
type: SpeciesReference

93
kinetic law: 070892
modifier: 070880
product: 070868
reactant: 070856
fast: false
reversible: false
name: r39
type: Reaction

978649
is: SBO:0000371
value: 5000.0
name: k
type: LocalParameter

83
kinetic law: 070410
product: 070398
reactant: 070386
reactant: 070374
fast: false
reversible: false
name: r29
type: Reaction

072230
is: SBO:0000010
stoichiometry: 1.0
species: 34
type: SpeciesReference

28
is: P07204
constant: false
boundary condition: false
has only substance units: false
initial concentration: 50.0
initial amount: NaN
in compartment: 226
name: Tmod
type: Species

111
kinetic law: 071652
product: 071640
reactant: 071628
fast: false
reversible: false
name: dXF
type: Reaction

072110
is: SBO:0000010
stoichiometry: 1.0
species: 39
type: SpeciesReference

54
is: CHEBI:28384
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: VK_p
type: Species

978612
is: SBO:0000025
value: 2.0
name: v
type: LocalParameter

185
constant: true
value: 24.0
name: VitaminK_Vc
type: Parameter

68
kinetic law: 069701
modifier: 069689
product: 069677
reactant: 069665
fast: false
reversible: false
name: r14
type: Reaction

40
boundary condition: false
has part: CHEBI:28304
initial amount: NaN
has only substance units: false
name: ATIII_Heparin
has part: P01008
type: Species
initial concentration: 0.0
constant: false
in compartment: 226

071556
is: SBO:0000010
stoichiometry: 1.0
species: 19
type: SpeciesReference

171
constant: true
value: 0.34
name: IC50
type: Parameter

15
is: P12259
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.7
initial amount: NaN
in compartment: 226
name: V
type: Species

101
kinetic law: 071278
modifier: 071266
product: 071254
reactant: 071242
fast: false
reversible: false
name: r47
type: Reaction

191
is: SBO:0000038
constant: true
value: 5.08333333333333E-4
name: VitaminK_k21/Vc
type: Parameter

070542
is: SBO:0000011
stoichiometry: 1.0
species: 32
type: SpeciesReference

82
kinetic law: 070362
product: 070350
reactant: 070338
reactant: 070326
fast: false
reversible: false
name: r28
type: Reaction

92
kinetic law: 070843
modifier: 070831
product: 070819
reactant: 070806
fast: false
reversible: false
name: r38
type: Reaction

069761
is: SBO:0000010
stoichiometry: 1.0
species: 18
type: SpeciesReference

29
is: P13726
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: TF
type: Species

176
constant: true
value: 60.0
name: PC(0)
type: Parameter

069869
is: SBO:0000011
stoichiometry: 1.0
species: 47
type: SpeciesReference

069030
unit: 069042
name: substance
type: SBMLUnitsDef

070770
is: SBO:0000010
stoichiometry: 1.0
species: 34
type: SpeciesReference

223
is: SBO:0000036
constant: true
value: 0.85
name: c46
type: Parameter

166
kinetic law: 073013
product: 073001
fast: false
reversible: false
name: pTFPI
type: Reaction

070302
is: SBO:0000011
stoichiometry: 1.0
species: 36
type: SpeciesReference

135
kinetic law: 072242
reactant: 072230
fast: false
reversible: false
name: dPS
type: Reaction

072134
is: SBO:0000010
stoichiometry: 1.0
species: 24
type: SpeciesReference

071966
is: SBO:0000010
stoichiometry: 1.0
species: 6
type: SpeciesReference

125
kinetic law: 072002
reactant: 071990
fast: false
reversible: false
name: dXII
type: Reaction

070904
is: SBO:0000010
stoichiometry: 1.0
species: 10
type: SpeciesReference

072687
is: SBO:0000010
stoichiometry: 1.0
species: 40
type: SpeciesReference

069965
is: SBO:0000011
stoichiometry: 1.0
species: 50
type: SpeciesReference

175
constant: true
value: 174.3
name: X(0)
type: Parameter

071012
is: SBO:0000011
stoichiometry: 1.0
species: 9
type: SpeciesReference

070002
is: SBO:0000010
stoichiometry: 1.0
species: 24
type: SpeciesReference

069665
is: SBO:0000010
stoichiometry: 1.0
species: 19
type: SpeciesReference

165
kinetic law: 072989
product: 072977
fast: false
reversible: false
name: pTmod
type: Reaction

222
is: SBO:0000036
constant: true
value: 0.85
name: c45
type: Parameter

978660
is: SBO:0000025
value: 2.0
name: v
type: LocalParameter

978680
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

071158
is: SBO:0000010
stoichiometry: 1.0
species: 40
type: SpeciesReference

164
kinetic law: 072965
product: 072953
fast: false
reversible: false
name: pPg
type: Reaction

136
kinetic law: 072266
reactant: 072254
fast: false
reversible: false
name: dFDP
type: Reaction

978747
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

978609
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

126
kinetic law: 072026
reactant: 072014
fast: false
reversible: false
name: dXIIa
type: Reaction

069191
is: SBO:0000010
stoichiometry: 1.0
species: 8
type: SpeciesReference

072470
is: SBO:0000010
stoichiometry: 1.0
species: 26
type: SpeciesReference

069905
is: SBO:0000010
stoichiometry: 1.0
species: 22
type: SpeciesReference

174
constant: true
value: 89.6
name: IX(0)
type: Parameter

978724
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

071448
is: SBO:0000011
stoichiometry: 1.0
species: 12
type: SpeciesReference

070782
is: SBO:0000011
stoichiometry: 1.0
species: 4
type: SpeciesReference

069042
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

211
constant: true
value: 30.6
name: XI(0)
type: Parameter

069055
is: SBO:0000010
stoichiometry: 1.0
species: 2
type: SpeciesReference

178
constant: true
value: 0.1
name: VKH2(0)
type: Parameter

221
is: SBO:0000036
constant: true
value: 0.119718309859155
name: c44
type: Parameter

70
kinetic law: 069797
modifier: 069785
product: 069773
reactant: 069761
fast: false
reversible: false
name: r16
type: Reaction

070916
is: SBO:0000011
stoichiometry: 1.0
species: 11
type: SpeciesReference

978748
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

137
kinetic law: 072290
reactant: 072278
fast: false
reversible: false
name: dD
type: Reaction

069953
is: SBO:0000010
stoichiometry: 1.0
species: 23
type: SpeciesReference

163
kinetic law: 072941
product: 072929
fast: false
reversible: false
name: pXIII
type: Reaction

123
kinetic law: 071954
reactant: 071942
fast: false
reversible: false
name: dIX
type: Reaction

50
has version: P00488
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: XIIIa
type: Species

978758
is: SBO:0000035
value: 0.05
name: k1
type: LocalParameter

71
kinetic law: 069845
modifier: 069833
product: 069821
reactant: 069809
fast: false
reversible: false
name: r17
type: Reaction

070014
is: SBO:0000011
stoichiometry: 1.0
species: 21
type: SpeciesReference

177
constant: true
value: 300.0
name: PS(0)
type: Parameter

210
constant: true
value: 0.7
name: VIII(0)
type: Parameter

069239
is: SBO:0000010
stoichiometry: 1.0
species: 8
type: SpeciesReference

220
constant: true
value: 1.0
name: R2
type: Parameter

071000
is: SBO:0000010
stoichiometry: 1.0
species: 38
type: SpeciesReference

069068
is: SBO:0000011
stoichiometry: 1.0
species: 3
type: SpeciesReference

069348
is: SBO:0000011
stoichiometry: 1.0
species: 13
type: SpeciesReference

072929
is: SBO:0000011
stoichiometry: 1.0
species: 23
type: SpeciesReference

138
kinetic law: 072314
reactant: 072302
fast: false
reversible: false
name: dTFPI
type: Reaction

978736
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

162
kinetic law: 072917
product: 072905
fast: false
reversible: false
name: pFg
type: Reaction

51
initial amount: NaN
name: IIa_ATIII_Heparin
boundary condition: false
initial concentration: 0.0
has part: P01008
has part: P00734
has part: CHEBI:28304
type: Species
has only substance units: false
constant: false
in compartment: 226

124
kinetic law: 071978
reactant: 071966
fast: false
reversible: false
name: dIXa
type: Reaction

978759
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

62
kinetic law: 069421
modifier: 069408
product: 069396
reactant: 069384
fast: false
reversible: false
name: r8
type: Reaction

071942
is: SBO:0000010
stoichiometry: 1.0
species: 5
type: SpeciesReference

072663
is: SBO:0000011
stoichiometry: 1.0
species: 54
type: SpeciesReference

978630
is: SBO:0000025
value: 500.0
name: v
type: LocalParameter

070422
is: SBO:0000010
stoichiometry: 1.0
species: 10
type: SpeciesReference

072158
is: SBO:0000010
stoichiometry: 1.0
species: 21
type: SpeciesReference

978711
is: SBO:0000035
value: 0.05
name: k1
type: LocalParameter

159
kinetic law: 072845
product: 072833
fast: false
reversible: false
name: pVIII
type: Reaction

070326
is: SBO:0000010
stoichiometry: 1.0
species: 1
type: SpeciesReference

072206
is: SBO:0000010
stoichiometry: 1.0
species: 25
type: SpeciesReference

149
kinetic law: 072578
reactant: 072566
fast: false
reversible: false
name: dCA
type: Reaction

88
kinetic law: 070650
modifier: 070638
product: 070626
reactant: 070614
fast: false
reversible: false
name: r34
type: Reaction

72
kinetic law: 069893
modifier: 069881
product: 069869
reactant: 069857
fast: false
reversible: false
name: r18
type: Reaction

213
constant: true
value: 8945.5
name: Fg(0)
type: Parameter

233
event assignment: 073133
trigger: 073121
use values from trigger time: true
name: dilution event
type: Event

978756
is: SBO:0000035
value: 0.2
name: k1
type: LocalParameter

978721
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

070290
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

107
kinetic law: 071508
modifier: 071496
product: 071484
fast: false
reversible: false
name: pPC_VKH2
type: Reaction

978742
is: SBO:0000035
value: 0.1
name: k1
type: LocalParameter

139
kinetic law: 072338
reactant: 072326
fast: false
reversible: false
name: dVIIa_TF
type: Reaction

978731
is: SBO:0000035
value: 0.69
name: k1
type: LocalParameter

978606
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

129
kinetic law: 072098
reactant: 072086
fast: false
reversible: false
name: dPk
type: Reaction

169
kinetic law: 073085
reactant: 073073
fast: false
reversible: false
name: dVK
type: Reaction

63
kinetic law: 069470
modifier: 069458
product: 069446
reactant: 069434
fast: false
reversible: false
name: r9
type: Reaction

978643
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

226
constant: false
size: 1.0
spatial dimensions: 3.0
name: compartment_1
type: Compartment

978605
is: SBO:0000025
value: 10.0
name: v
type: LocalParameter

069384
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

212
constant: true
value: 26.7
name: V(0)
type: Parameter

179
is: SBO:0000035
constant: true
value: 0.01
name: d_II
type: Parameter

89
kinetic law: 070698
modifier: 070686
product: 070674
reactant: 070662
fast: false
reversible: false
name: r35
type: Reaction

73
kinetic law: 069941
modifier: 069929
product: 069917
reactant: 069905
fast: false
reversible: false
name: r19
type: Reaction

199
is: SBO:0000035
constant: true
value: 0.012
name: d_XII
type: Parameter

232
event assignment: 073109
trigger: 073097
use values from trigger time: true
name: clottingTime event
type: Event

070626
is: SBO:0000011
stoichiometry: 1.0
species: 13
type: SpeciesReference

978670
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

108
kinetic law: 071544
modifier: 071532
product: 071520
fast: false
reversible: false
name: pPS_VKH2
type: Reaction

069336
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

070482
is: SBO:0000010
stoichiometry: 1.0
species: 32
type: SpeciesReference

072977
is: SBO:0000011
stoichiometry: 1.0
species: 28
type: SpeciesReference

978684
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

072278
is: SBO:0000010
stoichiometry: 1.0
species: 47
type: SpeciesReference

189
constant: true
value: 1.0
name: VK(0)
type: Parameter

168
kinetic law: 073061
product: 073049
fast: false
reversible: false
name: pVK
type: Reaction

978713
is: SBO:0000035
value: 67.4
name: k1
type: LocalParameter

978642
is: SBO:0000025
value: 1.0
name: v
type: LocalParameter

225
is: SBO:0000035
constant: true
value: 0.2052
name: d_VK
type: Parameter

60
kinetic law: 069324
modifier: 069312
product: 069299
reactant: 069287
fast: false
reversible: false
name: r6
type: Reaction

74
kinetic law: 069989
modifier: 069977
product: 069965
reactant: 069953
fast: false
reversible: false
name: r20
type: Reaction

215
constant: true
value: 2154.3
name: Pg(0)
type: Parameter

071520
is: SBO:0000011
stoichiometry: 1.0
species: 34
type: SpeciesReference

070338
is: SBO:0000010
stoichiometry: 1.0
species: 28
type: SpeciesReference

147
kinetic law: 072530
reactant: 072518
fast: false
reversible: false
name: dVIIa_TF_Xa_TFPI
type: Reaction

109
kinetic law: 071580
product: 071568
reactant: 071556
fast: false
reversible: false
name: dFg
type: Reaction

978754
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

069857
is: SBO:0000010
stoichiometry: 1.0
species: 22
type: SpeciesReference

127
kinetic law: 072050
reactant: 072038
fast: false
reversible: false
name: dXIII
type: Reaction

978608
is: SBO:0000025
value: 0.1
name: v
type: LocalParameter

188
constant: true
value: 0.228
name: d_VKO
type: Parameter

978733
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

978681
is: SBO:0000025
value: 1000.0
name: v
type: LocalParameter

119
kinetic law: 071858
reactant: 071846
fast: false
reversible: false
name: dVIII
type: Reaction

978744
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

069396
is: SBO:0000011
stoichiometry: 1.0
species: 13
type: SpeciesReference

167
kinetic law: 073037
product: 073025
fast: false
reversible: false
name: pPk
type: Reaction

071194
is: SBO:0000010
stoichiometry: 1.0
species: 6
type: SpeciesReference

61
kinetic law: 069372
modifier: 069360
product: 069348
reactant: 069336
fast: false
reversible: false
name: r7
type: Reaction

224
constant: false
value: NaN
name: clottingTime [s]
type: Parameter

069917
is: SBO:0000011
stoichiometry: 1.0
species: 47
type: SpeciesReference

186
constant: true
value: 0.0228
name: d_VK2
type: Parameter

214
constant: true
value: 70.3
name: XIII(0)
type: Parameter

978641
is: SBO:0000371
value: 100.0
name: k
type: LocalParameter

978631
is: SBO:0000371
value: 500.0
name: k
type: LocalParameter

75
kinetic law: 070038
modifier: 070026
product: 070014
reactant: 070002
fast: false
reversible: false
name: r21
type: Reaction

148
kinetic law: 072554
reactant: 072542
fast: false
reversible: false
name: dTAT
type: Reaction

978755
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

071484
is: SBO:0000011
stoichiometry: 1.0
species: 27
type: SpeciesReference

070398
is: SBO:0000011
stoichiometry: 1.0
species: 30
type: SpeciesReference

128
kinetic law: 072074
reactant: 072062
fast: false
reversible: false
name: dXIIIa
type: Reaction

978672
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

070494
is: SBO:0000011
stoichiometry: 1.0
species: 49
type: SpeciesReference

071339
is: SBO:0000011
stoichiometry: 1.0
species: 17
type: SpeciesReference

187
is: SBO:0000035
constant: true
value: 0.228
name: d_VKH2
type: Parameter

978745
is: SBO:0000035
value: 0.7
name: k1
type: LocalParameter

070614
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

978682
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

978673
is: SBO:0000025
value: 70.0
name: v
type: LocalParameter

073049
is: SBO:0000011
stoichiometry: 1.0
species: 42
type: SpeciesReference

072953
is: SBO:0000011
stoichiometry: 1.0
species: 24
type: SpeciesReference

070386
is: SBO:0000010
stoichiometry: 1.0
species: 29
type: SpeciesReference

070964
is: SBO:0000011
stoichiometry: 1.0
species: 9
type: SpeciesReference

978667
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

202
is: SBO:0000035
constant: true
value: 0.043
name: d_V
type: Parameter

069531
is: SBO:0000010
stoichiometry: 1.0
species: 16
type: SpeciesReference

145
kinetic law: 072482
reactant: 072470
fast: false
reversible: false
name: dIIa_Tmod
type: Reaction

W3 CDTF: Fri Apr 20 22:46:09 BST 2012

155
kinetic law: 072748
reactant: 072736
fast: false
reversible: false
name: eHeparinIXa
type: Reaction

978715
is: SBO:0000035
value: 0.05
name: k1
type: LocalParameter

978602
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

978653
is: SBO:0000371
value: 10000.0
name: k
type: LocalParameter

071145
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

978688
is: SBO:0000025
value: 1.0
name: v
type: LocalParameter

978674
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

BIOMD0000000338
reaction: 158
reaction: 80
parameter: 171
reaction: 100
reaction: 71
substance units: 069030
reaction: 160
parameter: 192
reaction: 92
units def: 069030
parameter: 183
compartment: 226
reaction: 112
name: Factor production
species: 52
curated: true
species: 16
reaction: 67
reaction: 69
reaction: 85
parameter: 200
reaction: 105
parameter: 210
species: 40
reaction: 88
reaction: 108
species: 21
parameter: 197
reaction: 126
reaction: 97
parameter: 175
parameter: 177
species: 38
reaction: 142
parameter: 206
reaction: 117
reaction: 144
parameter: 216
parameter: 222
is described by: http://identifiers.org/pubmed/19516255
species: 44
reaction: 147
species: 8
reaction: 165
reaction: 163
reaction: 138
volume units: 058815
species: 26
reaction: 156
species: 43
encodes: GO:0072378
parameter: 215
reaction: 159
species: 31
function def: 228
parameter: 190
parameter: 181
reaction: 62
type: SBMLModel
rule: 235
reaction: 65
reaction: 56
reaction: 83
reaction: 58
reaction: 103
reaction: 74
name: Warfarin inhibited first order kinetics
reaction: 121
event: 233
reaction: 77
reaction: 79
parameter: 195
rule: 234
reaction: 124
reaction: 95
species: 36
reaction: 140
parameter: 204
reaction: 115
species: 2

203
is: SBO:0000035
constant: true
value: 0.032
name: d_Fg
type: Parameter

070518
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

146
kinetic law: 072506
reactant: 072494
fast: false
reversible: false
name: dXa_TFPI
type: Reaction

069725
is: SBO:0000011
stoichiometry: 1.0
species: 46
type: SpeciesReference

071097
is: SBO:0000010
stoichiometry: 1.0
species: 1
type: SpeciesReference

070446
is: SBO:0000011
stoichiometry: 1.0
species: 31
type: SpeciesReference

156
kinetic law: 072772
reactant: 072760
fast: false
reversible: false
name: eHeparinIIa
type: Reaction

W3 CDTF: Tue Jul 05 18:06:28 BST 2011

978654
is: SBO:0000025
value: 2.0
name: v
type: LocalParameter

072590
is: SBO:0000010
stoichiometry: 1.0
species: 7
type: SpeciesReference

070374
is: SBO:0000010
stoichiometry: 1.0
species: 11
type: SpeciesReference

069105
is: SBO:0000010
stoichiometry: 1.0
species: 3
type: SpeciesReference

978685
is: SBO:0000025
value: 1.0
name: v
type: LocalParameter

978675
is: SBO:0000025
value: 900.0
name: v
type: LocalParameter

978717
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

142
kinetic law: 072410
reactant: 072398
fast: false
reversible: false
name: dVa_Xa
type: Reaction

071290
is: SBO:0000010
stoichiometry: 1.0
species: 44
type: SpeciesReference

072086
is: SBO:0000010
stoichiometry: 1.0
species: 45
type: SpeciesReference

143
kinetic law: 072434
reactant: 072422
fast: false
reversible: false
name: dIXa_VIIIa
type: Reaction

200
is: SBO:0000035
constant: true
value: 0.058
name: d_VIII
type: Parameter

978655
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

072566
is: SBO:0000010
stoichiometry: 1.0
species: 37
type: SpeciesReference

157
kinetic law: 072796
reactant: 072784
fast: false
reversible: false
name: dXI
type: Reaction

978604
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

978676
is: SBO:0000371
value: 200.0
name: k
type: LocalParameter

978686
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

201
constant: true
value: 0.1
name: d_XI
type: Parameter

073073
is: SBO:0000010
stoichiometry: 1.0
species: 42
type: SpeciesReference

071724
is: SBO:0000010
stoichiometry: 1.0
species: 29
type: SpeciesReference

071664
is: SBO:0000010
stoichiometry: 1.0
species: 17
type: SpeciesReference

144
kinetic law: 072458
reactant: 072446
fast: false
reversible: false
name: dTmod
type: Reaction

072326
is: SBO:0000010
stoichiometry: 1.0
species: 30
type: SpeciesReference

072014
is: SBO:0000010
stoichiometry: 1.0
species: 9
type: SpeciesReference

978666
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

072651
is: SBO:0000010
stoichiometry: 1.0
species: 42
type: SpeciesReference

158
kinetic law: 072821
product: 072808
fast: false
reversible: false
name: pXII
type: Reaction

069713
is: SBO:0000010
stoichiometry: 1.0
species: 19
type: SpeciesReference

070434
is: SBO:0000010
stoichiometry: 1.0
species: 29
type: SpeciesReference

140
kinetic law: 072362
reactant: 072350
fast: false
reversible: false
name: dVII_TF
type: Reaction

069580
is: SBO:0000011
stoichiometry: 1.0
species: 1
type: SpeciesReference

121
kinetic law: 071906
reactant: 071894
fast: false
reversible: false
name: dX
type: Reaction

978709
is: SBO:0000035
value: 0.05
name: k1
type: LocalParameter

150
kinetic law: 072603
reactant: 072590
fast: false
reversible: false
name: dXIa
type: Reaction

978719
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

072494
is: SBO:0000010
stoichiometry: 1.0
species: 32
type: SpeciesReference

978663
is: SBO:0000036
value: 0.01
name: c
type: LocalParameter

071303
is: SBO:0000011
stoichiometry: 1.0
species: 42
type: SpeciesReference

130
kinetic law: 072122
reactant: 072110
fast: false
reversible: false
name: dK
type: Reaction

073025
is: SBO:0000011
stoichiometry: 1.0
species: 45
type: SpeciesReference

120
kinetic law: 071882
reactant: 071870
fast: false
reversible: false
name: dVIIIa
type: Reaction

141
kinetic law: 072386
reactant: 072374
fast: false
reversible: false
name: dAPC_PS
type: Reaction

122
kinetic law: 071930
reactant: 071918
fast: false
reversible: false
name: dXa
type: Reaction

071049
is: SBO:0000010
stoichiometry: 1.0
species: 45
type: SpeciesReference

132
kinetic law: 072170
reactant: 072158
fast: false
reversible: false
name: dP
type: Reaction

978678
is: SBO:0000025
value: 70.0
name: v
type: LocalParameter

151
kinetic law: 072639
product: 072627
reactant: 072615
fast: false
reversible: false
name: dVKH2
type: Reaction

978738
is: SBO:0000035
value: 20.4
name: k1
type: LocalParameter

131
kinetic law: 072146
reactant: 072134
fast: false
reversible: false
name: dPg
type: Reaction

978728
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

978664
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

070662
is: SBO:0000010
stoichiometry: 1.0
species: 5
type: SpeciesReference

069434
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

071121
is: SBO:0000011
stoichiometry: 1.0
species: 51
type: SpeciesReference

072542
is: SBO:0000010
stoichiometry: 1.0
species: 48
type: SpeciesReference

071990
is: SBO:0000010
stoichiometry: 1.0
species: 38
type: SpeciesReference

152
kinetic law: 072675
product: 072663
reactant: 072651
fast: false
reversible: true
name: VK_transport
type: Reaction

133
kinetic law: 072194
reactant: 072182
fast: false
reversible: false
name: dPC
type: Reaction

978600
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

978661
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

070350
is: SBO:0000011
stoichiometry: 1.0
species: 26
type: SpeciesReference

072398
is: SBO:0000010
stoichiometry: 1.0
species: 36
type: SpeciesReference

978651
is: SBO:0000025
value: 5.0
name: v
type: LocalParameter

069494
is: SBO:0000011
stoichiometry: 1.0
species: 16
type: SpeciesReference

978726
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

153
kinetic law: 072700
reactant: 072687
fast: false
reversible: false
name: eHeparin
type: Reaction

072038
is: SBO:0000010
stoichiometry: 1.0
species: 23
type: SpeciesReference

071640
is: SBO:0000011
stoichiometry: 1.0
species: 47
type: SpeciesReference

134
kinetic law: 072218
reactant: 072206
fast: false
reversible: false
name: dAPC
type: Reaction

071061
is: SBO:0000011
stoichiometry: 1.0
species: 39
type: SpeciesReference

069446
is: SBO:0000011
stoichiometry: 1.0
species: 13
type: SpeciesReference

154
kinetic law: 072724
reactant: 072712
fast: false
reversible: false
name: eHeparinXa
type: Reaction

073097
persistant: true
initial value: true
type: Trigger

071749
is: SBO:0000010
stoichiometry: 1.0
species: 15
type: SpeciesReference

070674
is: SBO:0000011
stoichiometry: 1.0
species: 6
type: SpeciesReference