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083442
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value: 2.2
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083494
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value: 8.0
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083510
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constant: true
value: 2.0
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083470
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name: KIP
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083520
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constant: true
value: 4.0
name: n
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value: 0.2
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083488
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083464
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initial amount: NaN

083450
is: SBO:0000186
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value: 1.0
name: vsT
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value: 0.8
name: k1
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083480
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constant: true
value: 0.2
name: k2
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083426
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constant: true
value: 1.1
name: vsP
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083446
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constant: false
value: NaN
name: Pt
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083484
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value: 0.6
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083500
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083401
constant: true
size: 1.0
spatial dimensions: 3.0
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083518
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value: 2.0
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083504
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constant: true
value: 2.0
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BIOMD0000000298
parameter: 083510
parameter: 083480
species: 083462
parameter: 083454
parameter: 083516
rule: 083415
compartment: 083401
species: 083434
modified:
  W3 CDTF: Tue Jan 18 15:52:44 GMT 2011
curated: true
parameter: 083436
species: 083470
rule: 083403
species: 083474
parameter: 083508
parameter: 083444
type: SBMLModel
species: 083440
substance units: metaid_0000170
rule: 083419
parameter: 083498
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
is version of: GO:0007623
rule: 083413
parameter: 083502
parameter: 083486
parameter: 083430
parameter: 083452
parameter: 083472
parameter: 083488
length unit: length
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
area units: area
parameter: 083460
is: MODEL0478965170
parameter: 083432
parameter: 083490
is derived from: BIOMD0000000171
parameter: 083506
is described by: http://identifiers.org/pubmed/10643740
species: 083438
parameter: 083476
parameter: 083496
parameter: 083514
parameter: 083442
rule: 083407
parameter: 083500
parameter: 083484
occurs in: http://identifiers.org/taxonomy/7227
species: 083458
parameter: 083494
species: 083424
parameter: 083456
rule: 083411
rule: 083421
rule: 083417
parameter: 083520
name: Leloup1999_CircadianRhythms_Drosophila
parameter: 083482
species: 083464
rule: 083423
rule: 083405
parameter: 083478
parameter: 083518
time units: metaid_0000168
created:
  W3 CDTF: Tue Apr 28 16:31:24 BST 2009
notes: This a model from the article: Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora. Leloup JC, Gonze D, Goldbeter A. J Biol Rhythms. 1999 Dec;14(6):433-48. 10643740 , Abstract: We examine theoretical models for circadian oscillations based on transcriptional regulation in Drosophila and Neurospora. For Drosophila, the molecular model is based on the negative feedback exerted on the expression of the per and tim genes by the complex formed between the PER and TIM proteins. For Neurospora, similarly, the model relies on the feedback exerted on the expression of the frq gene by its protein product FRQ. In both models, sustained rhythmic variations in protein and mRNA levels occur in continuous darkness, in the form of limit cycle oscillations. The effect of light on circadian rhythms is taken into account in the models by considering that it triggers degradation of the TIM protein in Drosophila, and frq transcription in Neurospora. When incorporating the control exerted by light at the molecular level, we show that the models can account for the entrainment of circadian rhythms by light-dark cycles and for the damping of the oscillations in constant light, though such damping occurs more readily in the Drosophila model. The models account for the phase shifts induced by light pulses and allow the construction of phase response curves. These compare well with experimental results obtained in Drosophila. The model for Drosophila shows that when applied at the appropriate phase, light pulses of appropriate duration and magnitude can permanently or transiently suppress circadian rhythmicity. We investigate the effects of the magnitude of light-induced changes on oscillatory behavior. Finally, we discuss the common and distinctive features of circadian oscillations in the two organisms. This particular version of the model has been translated from equations 1a-1j (Drosophila). This model was taken from the CellML reposit…
parameter: 083428
parameter: 083504
parameter: 083450
parameter: 083466
volume units: volume
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parameter: 083492

083514
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083474
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type: Species
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boundary condition: false
constant: false
name: CN
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083508
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constant: true
value: 2.0
name: K2P
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083456
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value: 1.0
name: KIT
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083496
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value: 8.0
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083440
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083492
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083430
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constant: true
value: 0.2
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083452
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constant: true
value: 0.7
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083462
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name: T1
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083482
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083424
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name: MP
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083502
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083444
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083438
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has only substance units: false
initial amount: NaN
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083434
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083448
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type: Species
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has only substance units: false
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083472
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value: 0.01
name: kdC
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083506
is: SBO:0000027
constant: true
value: 2.0
name: K1T
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083512
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constant: true
value: 2.0
name: K3P
type: Parameter