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BIOMD0000000272
species: 688632
species: 688628
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reaction: 688636
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volume units: 773761
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creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
type: SBMLModel
creator:
  ORG:
    orgname: German Cancer Research Center
  n:
    given: Marcel
    family: Schilling
reaction: 688639
is part of: ko04640
compartment: 698626
notes: This is the auxiliary model described in the article: Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor Verena Becker, Marcel Schilling, Julie Bachmann, Ute Baumann, Andreas Raue, Thomas Maiwald, Jens Timmer and Ursula Klingmüller; Science Published Online May 20, 2010; DOI: 10.1126/science.1184913 PMID: 20488988 Abstract: Cell surface receptors convert extracellular cues into receptor activation, thereby triggering intracellular signaling networks and controlling cellular decisions. A major unresolved issue is the identification of receptor properties that critically determine processing of ligand-encoded information. We show by mathematical modeling of quantitative data and experimental validation that rapid ligand depletion and replenishment of cell surface receptor are characteristic features of the erythropoietin (Epo) receptor (EpoR). The amount of Epo-EpoR complexes and EpoR activation integrated over time corresponds linearly to ligand input, covering a broad range of ligand concentrations. This relation solely depends on EpoR turnover independent of ligand binding, suggesting an essential role of large intracellular receptor pools. These receptor properties enable the system to cope with basal and acute demand in the hematopoietic system. SBML model exported from PottersWheel. % PottersWheel model definition file function m = BeckerSchilling2010_EpoR_AuxiliaryMode() m = pwGetEmptyModel(); %% Meta information m.ID = 'BeckerSchilling2010_EpoR_AuxiliaryMode'; m.name = 'BeckerSchilling2010_EpoR_AuxiliaryModel'; m.description = 'BeckerSchilling2010_EpoR_AuxiliaryModel'; m.authors = {'Verena Becker',' Marcel Schilling'}; m.dates = {'2010'}; m.type = 'PW-2-0-42'; %% X: Dynamic variables % m = pwAddX(m, ID, startValue, type, minValue, maxValue, unit, compartment, name, description, typeOfStartValue) m = pwAddX(m, 'EpoR' , 76, 'fix' , 0, 10000, [], 'cell', [] , [] , [] , [] , 'protein.generic'); m = pwAddX(m, 'SAv' , 999.293, 'glo…
species: 688627
created:
  W3 CDTF: Wed May 26 17:11:31 BST 2010
parameter: 688656
reaction: 688643
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modified:
  W3 CDTF: Tue Jan 31 13:51:44 GMT 2012
area units: metaid_0000005
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creator:
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    orgname: Department of Systems Biology, Harvard Medical School, Boston, USA
  n:
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    family: Becker
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units def: 816003
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is described by: http://identifiers.org/pubmed/20488988
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units def: 815943
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reaction: 688634
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name: Becker2010_EpoR_AuxiliaryModel
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parameter: 688658
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length unit: length
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occurs in: http://identifiers.org/taxonomy/39107
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curated: true

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