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is version of: CHEBI:24875
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529995
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time units: 506005
reaction: 196804
reaction: 196616
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reaction: 196491
curated: true
species: 196251
species: 196395
compartment: 196141
reaction: 196867
creator:
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    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
name: Tiago2010_FeMetabolism_FeDeficient
species: 196359
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is described by: http://identifiers.org/pubmed/20704761
reaction: 196742
is: MODEL4152801381
reaction: 196930
type: SBMLModel
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reaction: 196846
reaction: 196637
area units: metaid_0000005
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notes: This a model from the article: Systems analysis of iron metabolism: the network of iron pools and fluxes Tiago JS Lopes, Tatyana Luganskaja, Maja Vujic-Spasic, Matthias W Hentze, Martina U Muckenthaler, K laus Schumann and Jens G Reich BMC Systems Biology 2010, Aug 13;4(1):112. 20704761 , Abstract: Background Every cell of the mammalian organism needs iron in numerous oxido-reductive processes as well as fo r transport and storage of oxygen. The versatility of ionic iron makes it a toxic entity which can catalyze the production of radicals that damage vital membranous and macromolecular assemblies in t he cell. The mammalian organism maintains therefore a complex regulatory network of iron uptake, ex cretion and intra-body distribution. Intracellular regulation in different cell types is intertwine d with a global hormonal signaling structure. Iron deficiency as well as excess of iron are frequen t and serious human disorders. They can affect every cell, but also the organism as a whole. Results Here, we present a kinematic model of the dynamic system of iron pools and fluxes. It is based on f errokinetic data and chemical measurements in C57BL6 wild-type mice maintained on iron-deficient, i ron-adequate, or iron-loaded diet. The tracer iron levels in major tissues and organs (16 compartme nt) were followed for 28 days. The evaluation resulted in a whole-body model of fractional clearanc e rates. The analysis permits calculation of absolute flux rates in the steady-state, of iron distr ibution into different organs, of tracer-accessible pool sizes and of residence times of iron in th e different compartments in response to three states of iron-repletion induced by the dietary regim e. Conclusions This mathematical model presents a comprehensive physiological picture of mice under three differen t diets with varying iron contents. The quantitative results reflect systemic properties of iron me tabolism: dynamic closedness, hierarchy of time scales, switch-over respon…
reaction: 196532
modified:
  W3 CDTF: Tue May 15 22:57:46 BST 2012
reaction: 196888
reaction: 197056
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length unit: length
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creator:
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  n:
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    family: da Silva Lopes
reaction: 196469
species: 196323
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compartment: 196140
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species: 196341
created:
  W3 CDTF: Thu Aug 19 11:30:00 BST 2010
reaction: 196658
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196341
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197078
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529587
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529887
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529455
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529815
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530175
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529911
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529695
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529947
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529407
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529563
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197115
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196469
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529779
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530031
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530235
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529443
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529491
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