metaid_0000017
constant: false
value: NaN
name: Tsum
type: Parameter

metaid_0000012
is version of: CHEBI:15422
initial amount: NaN
is version of: C00002
type: Species
boundary condition: false
has only substance units: false
constant: false
initial concentration: 0.41
is: SBO:0000247
in compartment: metaid_0000008
name: ATP_2

metaid_0000004
notes: k1 represents the phosphofructo kinase activity
constant: true
value: 0.02
type: Parameter

metaid_0000008
is: GO:0005623
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

metaid_0000006
constant: true
value: 13.0
type: Parameter

metaid_0000010
type: Species
constant: false
name: ATP_1
is: SBO:0000247
initial amount: NaN
in compartment: metaid_0000008
initial concentration: 7.6
is version of: CHEBI:15422
boundary condition: false
is version of: C00002
has only substance units: false

metaid_0000018
constant: false
value: NaN
name: Tdiff
type: Parameter

BIOMD0000000254
is described by: http://identifiers.org/pubmed/10692299
is version of: GO:0006096
created:
  W3 CDTF: Mon Jul 26 13:19:53 BST 2010
species: metaid_0000010
rule: metaid_0000015
species: metaid_0000011
curated: true
is: MODEL1007260000
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
time units: 048429
name: Bier2000_GlycolyticOscillation
species: metaid_0000009
type: SBMLModel
occurs in: http://identifiers.org/taxonomy/4932
rule: metaid_0000020
modified:
  W3 CDTF: Wed Sep 15 14:18:14 BST 2010
parameter: metaid_0000004
parameter: metaid_0000017
rule: metaid_0000016
rule: metaid_0000013
parameter: metaid_0000006
notes: This a model from the article: How yeast cells synchronize their glycolytic oscillations: a perturbation analytic treatment Bier M, Bakker BM, Westerhoff HV. Biophys. J 2000 Mar;78(3):1087-93. 10692299 , Abstract: Of all the lifeforms that obtain their energy from glycolysis, yeast cells are among the most basic. Under certain conditions the concentrations of the glycolytic intermediates in yeast cells can oscillate. Individual yeast cells in a suspension can synchronize their oscillations to get in phase with each other. Although the glycolytic oscillations originate in the upper part of the glycolytic chain, the signaling agent in this synchronization appears to be acetaldehyde, a membrane-permeating metabolite at the bottom of the anaerobic part of the glycolytic chain. Here we address the issue of how a metabolite remote from the pacemaking origin of the oscillation may nevertheless control the synchronization. We present a quantitative model for glycolytic oscillations and their synchronization in terms of chemical kinetics. We show that, in essence, the common acetaldehyde concentration can be modeled as a small perturbation on the "pacemaker" whose effect on the period of the oscillations of cells in the same suspension is indeed such that a synchronization develops.
rule: metaid_0000019
length unit: length
substance units: 048404
parameter: metaid_0000003
volume units: metaid_0000003
rule: metaid_0000014
parameter: metaid_0000005
species: metaid_0000012
creator:
  ORG:
    orgname: Department of Surgery, Section of Plastic and Reconstructive Surgery, University of Chicago.
  n:
    given: Martin
    family: Bier
compartment: metaid_0000008
area units: metaid_0000005
parameter: metaid_0000018
parameter: metaid_0000007

metaid_0000003
notes: V_in represents the constant glucose inflow
constant: true
value: 0.36
type: Parameter

metaid_0000011
name: Glucose_2
is: SBO:0000247
is version of: C00293
initial amount: NaN
is version of: CHEBI:17234
initial concentration: 10.3
has only substance units: false
in compartment: metaid_0000008
type: Species
constant: false
boundary condition: false

metaid_0000009
is version of: CHEBI:17234
initial concentration: 6.6
name: Glucose_1
is version of: C00293
type: Species
in compartment: metaid_0000008
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

metaid_0000007
constant: true
value: 0.01
type: Parameter

metaid_0000005
constant: true
value: 6.0
type: Parameter