metaid_0000018
constant: true
value: 0.6
name: qE
type: Parameter

metaid_0000043
kinetic law: 510861
reactant: 510813
name: pRB/E2F complex dissociation via cyclin E
fast: false
is version of: GO:0043241
modifier: 510849
modifier: 510837
reversible: false
type: Reaction
product: 510825

metaid_0000033
is version of: Q61501
constant: false
boundary condition: false
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initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000029
name: RS
type: Species

metaid_0000023
constant: true
value: 0.08
name: aX
type: Parameter

metaid_0000008
constant: true
value: 0.16
name: aE
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metaid_0000028
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metaid_0000038
kinetic law: 510582
modifier: 510570
product: 510558
is version of: GO:0006412
fast: false
reversible: false
name: cyclinE synthesis
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metaid_0000013
constant: true
value: 0.8
name: qX
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510909
stoichiometry: 1.0
species: metaid_0000034
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metaid_0000042
name: pRB/E2F complex dissociation via cyclin D
modifier: 510789
modifier: 510777
type: Reaction
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reversible: false
product: 510765
reactant: 510753
is version of: GO:0043241
kinetic law: 510801

metaid_0000032
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metaid_0000009
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metaid_0000022
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metaid_0000029
is version of: GO:0005623
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modifier: 510607
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is version of: GO:0008054
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metaid_0000019
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metaid_0000012
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metaid_0000006
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metaid_0000045
kinetic law: 510945
modifier: 510933
modifier: 510921
reactant: 510909
is version of: GO:0030163
fast: false
reversible: false
name: E2F degradation via cell cycle progression
type: Reaction

510825
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species: metaid_0000034
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metaid_0000026
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510765
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species: metaid_0000034
type: SpeciesReference

metaid_0000025
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510594
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species: metaid_0000031
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510705
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species: metaid_0000032
type: SpeciesReference

metaid_0000007
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has part: P25322
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initial concentration: NaN
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in compartment: metaid_0000029
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metaid_0000044
kinetic law: 510897
modifier: 510885
product: 510873
is version of: GO:0006412
fast: false
reversible: false
name: E2F synthesis
type: Reaction

metaid_0000027
constant: true
value: 0.2
name: dE
type: Parameter

metaid_0000024
constant: true
value: 0.35
name: f
type: Parameter

metaid_0000010
constant: true
value: 0.9
name: aF
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510957
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

510643
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

metaid_0000047
kinetic law: 511041
modifier: 511029
reactant: 511017
is version of: GO:0051726
fast: false
reversible: false
name: cell cycle progression slow
type: Reaction

metaid_0000004
constant: true
value: 6.3
name: GF
type: Parameter

510729
stoichiometry: 1.0
species: metaid_0000033
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510813
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

metaid_0000037
kinetic law: 510546
modifier: 510533
modifier: 510521
reactant: 510509
is version of: GO:0008054
fast: false
reversible: false
name: cyclinD degradation
type: Reaction

metaid_0000014
constant: true
value: 0.6
name: pS
type: Parameter

510873
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

510509
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000046
type: Reaction
reversible: false
name: cell cycle progression go
kinetic law: 511005
is version of: GO:0051726
modifier: 510993
fast: false
modifier: 510981
product: 510957
modifier: 510969

510753
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

metaid_0000005
constant: true
value: 0.05
name: k1
type: Parameter

metaid_0000015
constant: true
value: 0.48
name: pD
type: Parameter

metaid_0000036
kinetic law: 510497
product: 510485
is version of: GO:0006412
fast: false
reversible: false
name: cyclinD synthesis
type: Reaction

510485
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000035
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000029
name: X
type: Species

metaid_0000016
constant: true
value: 0.6
name: qD
type: Parameter

metaid_0000021
constant: true
value: 0.12
name: dtheta
type: Parameter

metaid_0000041
kinetic law: 510741
product: 510729
reactant: 510717
reactant: 510705
is version of: GO:0035189
fast: false
reversible: false
name: pRB/E2F complex association
type: Reaction

510717
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

metaid_0000048
constant: false
value: NaN
name: Rb_phosphorylated
type: Parameter

BIOMD0000000242
species: metaid_0000031
parameter: metaid_0000026
parameter: metaid_0000023
reaction: metaid_0000040
parameter: metaid_0000048
reaction: metaid_0000044
parameter: metaid_0000009
creator:
  ORG:
    orgname: Department of Biomathematics, University of Texas
  n:
    given: Mandri
    family: Obeyeseker
compartment: metaid_0000029
name: Mass_Action_2
modified:
  W3 CDTF: Thu Aug 09 17:35:50 BST 2012
reaction: metaid_0000043
reaction: metaid_0000039
parameter: metaid_0000005
parameter: metaid_0000019
reaction: metaid_0000038
parameter: metaid_0000021
type: SBMLModel
parameter: metaid_0000013
parameter: metaid_0000015
is described by: http://identifiers.org/pubmed/12695688
parameter: metaid_0000012
species: metaid_0000032
curated: true
parameter: metaid_0000014
parameter: metaid_0000006
species: metaid_0000033
created:
  W3 CDTF: Fri Mar 05 16:22:00 GMT 2010
parameter: metaid_0000022
parameter: metaid_0000008
reaction: metaid_0000042
is version of: GO:0000114
function def: metaid_0000003
parameter: metaid_0000004
reaction: metaid_0000047
length unit: length
parameter: metaid_0000020
parameter: metaid_0000028
parameter: metaid_0000025
parameter: metaid_0000011
time units: metaid_0000040
parameter: metaid_0000027
species: metaid_0000034
occurs in: http://identifiers.org/taxonomy/39107
parameter: metaid_0000010
species: metaid_0000030
parameter: metaid_0000018
reaction: metaid_0000041
reaction: metaid_0000045
reaction: metaid_0000037
notes: This a model from the article: Theoretical and experimental evidence for hysteresis in cell proliferation. Bai S, Goodrich D, Thron CD, Tecarro E, Obeyesekere M. Cell Cycle. 2003 Jan-Feb;2(1):46-52. 12695688 , Abstract: We propose a mathematical model for the regulation of the G1-phase of the mammalian cell cycle taking into account interactions of cyclin D/cdk4, cyclin E/cdk2, Rb and E2F. Mathematical analysis of this model predicts that a change in the proliferative status in response to a change in concentrations of serum growth factors will exhibit the property of hysteresis: the concentration of growth factors required to induce proliferation is higher than the concentration required to maintain proliferation. We experimentally confirmed this prediction in mouse embryonic fibroblasts in vitro. In agreement with the mathematical model, this indicates that changes in proliferative mode caused by small changes in concentrations of growth factors are not easily reversible. Based on this study, we discuss the importance of proliferation hysteresis for cell cycle regulation. The original model was taken from the Cell Cycle DataBase (CCDB). Variable added: assignment rule for denoting phosphorylated Rb (Rb_phosphorylated i.e(RT-RS-R)) created. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative …
reaction: metaid_0000036
rule: metaid_0000049
substance units: metaid_0000039
name: Bai2003_G1phaseRegulation
is: MODEL1003050000
parameter: metaid_0000017
reaction: metaid_0000046
volume units: metaid_0000003
parameter: metaid_0000016
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
is version of: REACT 1590
area units: metaid_0000005
species: metaid_0000035
parameter: metaid_0000007
parameter: metaid_0000024

510558
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

metaid_0000034
is version of: Q61501
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000029
name: theta
type: Species

metaid_0000017
constant: true
value: 0.096
name: pE
type: Parameter

metaid_0000020
constant: true
value: 1.5
name: k3
type: Parameter

metaid_0000040
is version of: GO:0006412
type: Reaction
modifier: 510681
reversible: false
modifier: 510669
fast: false
name: pRB synthesis
modifier: 510656
kinetic law: 510693
product: 510643

511017
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference