metaid_0000029
kinetic law: 655465
modifier: 655453
product: 655441
is version of: GO:0006412
fast: false
reversible: false
type: Reaction

metaid_0000030
kinetic law: 655489
reactant: 655477
is version of: GO:0019941
fast: false
reversible: false
type: Reaction

metaid_0000007
constant: true
value: 0.1
type: Parameter

metaid_0000020
constant: true
value: 0.1
type: Parameter

655501
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000039
kinetic law: 655791
reactant: 655779
fast: false
reversible: false
type: Reaction

655707
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000040
kinetic law: 655815
reactant: 655803
is version of: GO:0019941
fast: false
reversible: false
type: Reaction

metaid_0000006
constant: true
value: 10.0
type: Parameter

metaid_0000028
is version of: P05412
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000021
name: AP-1
type: Species

metaid_0000038
kinetic law: 655767
product: 655755
reactant: 655743
fast: false
reversible: false
type: Reaction

metaid_0000010
constant: true
value: 0.01
type: Parameter

655549
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

655634
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

655803
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000027
constant: false
has part: P24941
name: active cycE_cdk2
type: Species
has only substance units: false
boundary condition: false
has part: P24864
initial concentration: 1.0E-4
initial amount: NaN
in compartment: metaid_0000021

metaid_0000032
kinetic law: 655573
modifier: 655561
product: 655549
reactant: 655537
is version of: GO:0004693
fast: false
reversible: false
type: Reaction

metaid_0000009
constant: true
value: 0.4
type: Parameter

metaid_0000011
constant: true
value: 0.1
type: Parameter

metaid_0000031
kinetic law: 655525
modifier: 655513
product: 655501
is version of: GO:0045727
is version of: GO:0003700
fast: false
reversible: false
type: Reaction

metaid_0000026
initial amount: NaN
boundary condition: false
has part: P24864
constant: false
type: Species
has only substance units: false
in compartment: metaid_0000021
has part: P24941
name: inactive cycE_cdk2
initial concentration: 0.0

655887
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000008
constant: true
value: 1.0
type: Parameter

metaid_0000012
constant: true
value: 0.09
type: Parameter

655441
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

655779
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000013
constant: true
value: 0.1
type: Parameter

655585
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000035
kinetic law: 655658
modifier: 655646
product: 655634
is version of: GO:0045727
is version of: GO:0003700
fast: false
reversible: false
type: Reaction

655755
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

655671
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000025
is version of: P06400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000021
name: Phosphorylated pRB
type: Species

metaid_0000004
constant: true
value: 1.0
type: Parameter

655609
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

metaid_0000014
constant: true
value: 1.0
type: Parameter

metaid_0000034
kinetic law: 655621
reactant: 655609
is version of: GO:0019941
fast: false
reversible: false
type: Reaction

655827
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000024
is version of: P06400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.006
initial amount: NaN
in compartment: metaid_0000021
name: pRB
type: Species

metaid_0000023
is version of: Q01094
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.014
initial amount: NaN
in compartment: metaid_0000021
name: E2F
type: Species

metaid_0000005
constant: true
value: 1.0
type: Parameter

metaid_0000043
kinetic law: 655899
reactant: 655887
is version of: GO:0019941
fast: false
reversible: false
type: Reaction

metaid_0000015
constant: true
value: 2.0
type: Parameter

metaid_0000033
kinetic law: 655597
reactant: 655585
is version of: GO:0019941
fast: false
reversible: false
type: Reaction

BIOMD0000000208
occurs in: http://identifiers.org/taxonomy/40674
created:
  W3 CDTF: Sat Sep 13 06:21:44 BST 2008
length unit: length
parameter: metaid_0000011
parameter: metaid_0000010
volume units: metaid_0000059
parameter: metaid_0000006
time units: metaid_0000062
is version of: hsa04110
substance units: metaid_0000044
species: metaid_0000023
reaction: metaid_0000035
area units: metaid_0000005
reaction: metaid_0000040
parameter: metaid_0000017
parameter: metaid_0000016
notes: The model reproduces Fig 3 of the paper corresponding to the transition to S phase. Units have not been defined for this model because the paper mentions the use of arbitrary units for the various species and parameters. Model reproduced using MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
species: metaid_0000026
reaction: metaid_0000031
is version of: GO:0000278
reaction: metaid_0000030
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
parameter: metaid_0000012
rule: metaid_0000044
parameter: metaid_0000008
parameter: metaid_0000007
species: metaid_0000025
is: MODEL1475866846
reaction: metaid_0000037
reaction: metaid_0000042
reaction: metaid_0000036
reaction: metaid_0000041
type: SBMLModel
species: metaid_0000028
reaction: metaid_0000033
reaction: metaid_0000032
parameter: metaid_0000004
parameter: metaid_0000003
parameter: metaid_0000013
curated: true
modified:
  W3 CDTF: Thu Jul 05 15:41:04 BST 2012
parameter: metaid_0000009
compartment: metaid_0000021
name: Deineko2003_CellCycle
reaction: metaid_0000039
reaction: metaid_0000029
reaction: metaid_0000038
is described by: http://identifiers.org/pubmed/14582399
parameter: metaid_0000020
reaction: metaid_0000043
species: metaid_0000024
parameter: metaid_0000019
parameter: metaid_0000018
reaction: metaid_0000034
parameter: metaid_0000005
parameter: metaid_0000015
parameter: metaid_0000014
species: metaid_0000027

655477
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

metaid_0000037
kinetic law: 655731
product: 655719
reactant: 655707
is version of: GO:0000082
fast: false
reversible: false
type: Reaction

655743
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

655537
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000018
constant: true
value: 0.0
type: Parameter

metaid_0000016
constant: true
value: 0.01
type: Parameter

metaid_0000042
kinetic law: 655875
product: 655863
is version of: GO:0006412
fast: false
reversible: false
type: Reaction

metaid_0000036
kinetic law: 655695
modifier: 655683
product: 655671
is version of: GO:0045727
is version of: GO:0003700
fast: false
reversible: false
type: Reaction

655863
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

655719
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000003
constant: true
value: 2.0
type: Parameter

metaid_0000021
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

metaid_0000019
constant: false
value: 0.044
type: Parameter

metaid_0000017
constant: true
value: 0.01
type: Parameter

metaid_0000041
kinetic law: 655851
modifier: 655839
product: 655827
is version of: GO:0003700
is version of: GO:0045727
fast: false
reversible: false
type: Reaction