323034
is: SBO:0000336
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000044
constant: true
units: dimensionless
value: 0.0
type: Parameter

metaid_0000007
notes: u = 1 : kinetochore unattached u = 0 : kinetochore attached
constant: false
units: dimensionless
value: 1.0
type: Parameter

metaid_0000003
is: SBO:0000338
constant: true
units: metaid_0000042
value: 0.01
type: Parameter

322961
is: SBO:0000011
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

322877
is: SBO:0000336
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

323010
is: SBO:0000011
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000017
initial concentration: 0.0
is: SBO:0000297
has part: Q9Y6D9
type: Species
boundary condition: false
constant: false
substance units: mole
has part: Q13257
initial amount: NaN
name: Mad1:C-Mad2:O-Mad2*
has only substance units: false
in compartment: metaid_0000014

323107
is: SBO:0000011
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000027
type: Reaction
kinetic law: 323119
is version of: GO:0043241
product: 323107
reversible: true
fast: false
is: SBO:0000177
reactant: 323095
is version of: GO:0006461
reactant: 323083

323143
is: SBO:0000336
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

323095
is: SBO:0000336
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

metaid_0000023
fast: false
reversible: true
kinetic law: 322913
product: 322901
is version of: GO:0006461
type: Reaction
reactant: 322877
reactant: 322889
is: SBO:0000177
is version of: GO:0032092
is version of: GO:0043241

322937
is: SBO:0000336
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

metaid_0000008
is: SBO:0000339
constant: true
units: metaid_0000043
value: 1.0E7
type: Parameter

metaid_0000043
unit: 322865
unit: 322853
unit: 322841
name: liter per mole per second
type: SBMLUnitsDef

metaid_0000004
is: SBO:0000339
constant: true
units: metaid_0000043
value: 1000.0
type: Parameter

323083
is: SBO:0000336
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

322841
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

323059
is: SBO:0000011
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

metaid_0000014
is: GO:0005737
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cytoplasm
type: Compartment

metaid_0000020
has part: O43684
initial concentration: 1.3E-7
initial amount: NaN
substance units: mole
boundary condition: false
has part: O60566
constant: false
name: Bub3:BubR1
has only substance units: false
in compartment: metaid_0000014
type: Species
is: SBO:0000297

metaid_0000018
constant: false
initial concentration: 2.2E-7
is version of: Q12834
boundary condition: false
has only substance units: false
in compartment: metaid_0000014
substance units: mole
initial amount: NaN
type: Species
name: Cdc20

metaid_0000010
is: SBO:0000338
constant: true
units: metaid_0000042
value: 0.2
type: Parameter

metaid_0000028
reactant: 323143
reversible: false
is version of: GO:0006461
is: SBO:0000177
product: 323155
reactant: 323131
type: Reaction
kinetic law: 323167
fast: false

metaid_0000024
kinetic law: 322974
product: 322949
is version of: GO:0032092
type: Reaction
reversible: false
fast: false
product: 322961
is version of: GO:0006461
reactant: 322925
is: SBO:0000176
reactant: 322937

metaid_0000009
is: SBO:0000339
constant: true
units: metaid_0000043
value: 200000.0
type: Parameter

323155
is: SBO:0000011
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

322865
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

322901
is: SBO:0000011
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000025
is: SBO:0000180
kinetic law: 323022
reversible: false
is version of: GO:0043241
fast: false
product: 322998
product: 323010
reactant: 322986
type: Reaction

323179
persistant: true
initial value: true
type: Trigger

metaid_0000005
is: SBO:0000339
constant: true
units: metaid_0000043
value: 10000.0
type: Parameter

322998
is: SBO:0000011
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

323131
is: SBO:0000336
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000021
name: MCC
has part: Q12834
initial amount: NaN
is version of: GO:0033597
type: Species
substance units: mole
has only substance units: false
in compartment: metaid_0000014
boundary condition: false
has part: Q13257
has part: O60566
initial concentration: 0.0
has part: O43684
constant: false
is: SBO:0000297

metaid_0000015
has part: Q9Y6D9
boundary condition: false
type: Species
substance units: mole
is: SBO:0000297
has part: Q13257
constant: false
name: Mad1:C-Mad2
has only substance units: false
in compartment: metaid_0000014
initial concentration: 5.0E-8
initial amount: NaN

metaid_0000011
is: SBO:0000339
constant: true
units: metaid_0000043
value: 1.0E7
type: Parameter

322889
is: SBO:0000336
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

322925
is: SBO:0000336
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

322829
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

metaid_0000019
has part: Q12834
boundary condition: false
is: SBO:0000297
has part: Q13257
in compartment: metaid_0000014
type: Species
initial concentration: 0.0
initial amount: NaN
has only substance units: false
name: Cdc20:C-Mad2
constant: false
substance units: mole

322949
is: SBO:0000011
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

BIOMD0000000193
parameter: metaid_0000008
area units: metaid_0000005
is version of: REACT 2137.2
species: metaid_0000021
parameter: metaid_0000010
parameter: metaid_0000006
species: metaid_0000017
is: MODEL1667758030
reaction: metaid_0000026
creator:
  ORG:
    orgname: German Cancer Research Center, Heidelberg
  n:
    given: Bashar
    family: Ibrahim
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
species: metaid_0000019
parameter: metaid_0000045
modified:
  W3 CDTF: Wed Sep 23 18:12:59 BST 2009
parameter: metaid_0000044
type: SBMLModel
curated: true
units def: metaid_0000042
compartment: metaid_0000014
parameter: metaid_0000011
time units: metaid_0000008
reaction: metaid_0000023
creator:
  ORG:
    orgname: Fritz Lipmann Institute, Jena, Germany
  n:
    given: Eberhard
    family: Schmitt
parameter: metaid_0000012
substance units: metaid_0000040
created:
  W3 CDTF: Thu Nov 27 10:56:41 GMT 2008
creator:
  ORG:
    orgname: Fritz Lipmann Institute, Jena, Germany
  n:
    given: Stephan
    family: Diekmann
volume units: metaid_0000004
species: metaid_0000018
parameter: metaid_0000003
reaction: metaid_0000027
occurs in: http://identifiers.org/taxonomy/9606
species: metaid_0000016
creator:
  ORG:
    orgname: Friedrich-Schiller-University Jena, Germany
  n:
    given: Peter
    family: Dittrich
name: Ibrahim2008_MCC_assembly_model_KDM
parameter: metaid_0000007
reaction: metaid_0000024
units def: metaid_0000043
length unit: length
is described by: http://identifiers.org/pubmed/18675311
parameter: metaid_0000005
species: metaid_0000022
event: metaid_0000031
reaction: metaid_0000025
parameter: metaid_0000004
species: metaid_0000015
reaction: metaid_0000028
species: metaid_0000020
notes: BioSystems (2007), doi:10.1016/j.biosystems.2008.06.007 In-silico study of kinetochore control, amplification, and inhibition effects in MCC assembly Bashar Ibrahim, Eberhard Schmitt, Peter Dittrich, Stephan Diekmann This is the kinetochore dependent MCC model (KDM) from the article. For the kinetochore independent MCC model (KIM) replaceu*k4f inR4 byk4f andu*k5f inR5 byk5f . This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
is part of: hsa04110
parameter: metaid_0000009
is version of: GO:0007094

metaid_0000045
constant: true
units: dimensionless
value: 1.0
type: Parameter

322853
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000026
reactant: 323034
is version of: GO:0006461
reversible: true
is version of: GO:0043241
type: Reaction
reactant: 323046
kinetic law: 323071
product: 323059
is version of: REACT 36.2
fast: false
is: SBO:0000177

metaid_0000031
event assignment: 323191
trigger: 323179
is: GO:0008608
use values from trigger time: true
name: Microtubule attachment
type: Event

metaid_0000006
is: SBO:0000038
constant: true
units: metaid_0000042
value: 0.2
type: Parameter

metaid_0000016
initial amount: NaN
has only substance units: false
in compartment: metaid_0000014
boundary condition: false
name: O-Mad2
type: Species
is version of: Q13257
constant: false
substance units: mole
initial concentration: 1.3E-7
notes: Open conformation of Mad2

metaid_0000022
initial amount: NaN
initial concentration: 0.0
has part: O43684
type: Species
substance units: mole
has only substance units: false
in compartment: metaid_0000014
has part: Q12834
has part: O60566
name: Bub3:BubR1:Cdc20
constant: false
is: SBO:0000297
boundary condition: false

metaid_0000012
is: SBO:0000338
constant: true
units: metaid_0000042
value: 0.02
type: Parameter

323046
is: SBO:0000336
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000042
unit: 322829
name: per second
type: SBMLUnitsDef

322986
is: SBO:0000010
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference