799509
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000006
constant: true
units: metaid_0000077
value: 4.037081673984E-4
name: kphos (phosphorylation rate)
type: Parameter

metaid_0000059
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.16
reactant: 799352
is version of: GO:0004722
reactant: 799340
type: Reaction
product: 799364
name: Reaction 10A Dephos pS2 Nuc
fast: false
kinetic law: 799388
product: 799376

799763
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

metaid_0000031
initial amount: NaN
has only substance units: false
in compartment: metaid_0000019
has part: Q15796
type: Species
name: pSmad2/pSmad2_c
initial concentration: 0.0
has version: C00562
is version of: GO:0043234
boundary condition: false
constant: false

metaid_0000045
has version: GO:0030291
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000019
name: SB-431542
type: Species

metaid_0000072
kinetic law: 799981
product: 799969
reactant: 799957
is version of: GO:0006913
fast: false
reversible: false
name: Reaction 9C Import GG
type: Reaction

799689
stoichiometry: 2.0
species: metaid_0000037
type: SpeciesReference

799400
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

799811
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000005
constant: true
units: metaid_0000078
value: 1.26E-14
name: kex (export rate for monomeric Smads)
type: Parameter

799352
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000032
initial amount: NaN
has part: Q13485
has version: C00562
has only substance units: false
in compartment: metaid_0000019
initial concentration: 0.0
type: Species
is version of: GO:0043234
boundary condition: false
has part: Q15796
name: pSmad2/Smad4_c
constant: false

metaid_0000019
is: GO:0005737
constant: true
size: 2.27E-12
spatial dimensions: 3.0
name: Cyt
type: Compartment

798998
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

799629
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

metaid_0000071
kinetic law: 799945
product: 799933
reactant: 799921
reactant: 799909
is version of: GO:0006461
fast: false
reversible: true
name: Reaction 3D Formation G4_N
type: Reaction

metaid_0000057
kinetic law: 799292
product: 799279
reactant: 799267
is version of: GO:0006461
fast: false
reversible: true
name: Reaction 4A Formation S22_C
type: Reaction

metaid_0000008
constant: true
units: metaid_0000078
value: 3.36347821E-14
name: kin*CIF (Complex import rate)
type: Parameter

798974
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

metaid_0000018
is: GO:0005634
constant: true
size: 1.0E-12
spatial dimensions: 3.0
name: Nuc
type: Compartment

799267
stoichiometry: 2.0
species: metaid_0000035
type: SpeciesReference

metaid_0000070
kinetic law: 799897
product: 799885
reactant: 799872
reactant: 799860
is version of: GO:0006461
fast: false
reversible: true
name: Reaction 3C Formation G4_C
type: Reaction

799412
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000060
kinetic law: 799436
product: 799424
reactant: 799412
reactant: 799400
is version of: GO:0005160
fast: false
reversible: false
name: Reaction 1 TGFb Binding
type: Reaction

metaid_0000020
constant: true
is version of: GO:0004721
type: Species
boundary condition: true
is version of: P35813
initial amount: NaN
initial concentration: 1.0
has only substance units: false
in compartment: metaid_0000018
name: PPase

799957
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000007
constant: true
units: metaid_0000077
value: 0.00656639
name: kdephos (dephosphorylation rate)
type: Parameter

metaid_0000058
kinetic law: 799328
product: 799316
reactant: 799304
is version of: GO:0006461
fast: false
reversible: true
name: Reaction 4B Formation S22_N
type: Reaction

800041
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

metaid_0000017
constant: true
units: dimensionless
value: 6.0221415E14
name: quantity to number factor
type: Parameter

metaid_0000030
constant: false
in compartment: metaid_0000018
has version: IPR000786
name: pGFP-Smad2/pGFP_Smad2_n
has only substance units: false
initial amount: NaN
has version: C00562
initial concentration: 0.0
is version of: GO:0043234
boundary condition: false
type: Species
has part: Q15796

799364
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

799279
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

799665
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

799424
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

799120
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

799836
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

798962
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

799860
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

metaid_0000049
kinetic law: 798950
product: 798937
reactant: 798925
is version of: GO:0006913
fast: false
reversible: true
name: Reaction 7 Shuttling S4
type: Reaction

799787
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

metaid_0000069
kinetic law: 799848
product: 799836
reactant: 799823
reactant: 799811
is version of: GO:0006461
fast: false
reversible: true
name: Reaction 4D Formation G2_N
type: Reaction

metaid_0000009
constant: true
units: metaid_0000077
value: 0.00183925592901392
name: kon (Smad complex on-rate)
type: Parameter

metaid_0000029
in compartment: metaid_0000018
has version: Q13485
initial amount: NaN
has version: C00562
type: Species
boundary condition: false
name: pGFP-Smad2/Smad4_n
constant: false
has version: Q15796
has version: IPR000786
is version of: GO:0043234
has only substance units: false
initial concentration: 0.0

799059
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

799376
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

799921
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

799316
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

799473
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

799775
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

799872
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

799193
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

799046
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

800005
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

799460
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

799521
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

799933
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

799823
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000150
constant: true
units: metaid_0000075
value: 0.0
name: SB conc at start
type: Parameter

metaid_0000012
constant: false
units: metaid_0000075
value: 8.69917
name: Kdiss (dissociation constant of Smad complexes)
type: Parameter

799230
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

metaid_0000066
kinetic law: 799714
product: 799701
reactant: 799689
is version of: GO:0006461
fast: false
reversible: true
name: Reaction 4E Formation GG_C
type: Reaction

metaid_0000052
fast: false
reactant: 799046
kinetic law: 799084
product: 799071
product: 799059
name: Reaction 2A Phosphorylation S2
is version of: GO:0004675
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.30
reactant: 799034

metaid_0000026
has part: Q13485
in compartment: metaid_0000018
has part: Q15796
initial concentration: 0.0
type: Species
boundary condition: false
initial amount: NaN
name: pSmad2/Smad4_n
has version: C00562
is version of: GO:0043234
has only substance units: false
constant: false

799727
stoichiometry: 2.0
species: metaid_0000024
type: SpeciesReference

799533
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

798853
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

799034
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000065
kinetic law: 799677
product: 799665
reactant: 799653
is version of: GO:0006913
fast: false
reversible: true
name: Reaction 6B Shuttling pG
type: Reaction

metaid_0000039
initial amount: NaN
type: Species
constant: false
has part: Q13485
initial concentration: 0.0
in compartment: metaid_0000019
has version: C00562
name: pGFP-Smad2/Smad4_c
is version of: GO:0043234
boundary condition: false
has version: IPR000786
has only substance units: false
has part: Q15796

metaid_0000011
constant: false
units: dimensionless
value: 5.67197
name: CIF (complex import factor)
type: Parameter

798829
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000151
constant: true
units: metaid_0000075
value: 10000.0
name: SB conc after addition
type: Parameter

799071
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

798913
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

metaid_0000025
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 0.0
boundary condition: false
has version: C00562
is version of: GO:0043234
in compartment: metaid_0000018
name: pSmad2/pSmad2_n
has part: Q15796
type: Species

798865
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000051
kinetic law: 799022
product: 799010
reactant: 798998
is version of: GO:0006913
fast: false
reversible: true
name: Reaction 6A Shuttling pS2
type: Reaction

799581
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

metaid_0000010
constant: true
units: metaid_0000076
value: 0.016
name: koff (Smad complex off-rate)
type: Parameter

metaid_0000038
has version: IPR000786
has only substance units: false
has part: Q15796
initial amount: NaN
has version: C00562
type: Species
initial concentration: 0.0
is version of: GO:0043234
boundary condition: false
constant: false
name: pGFP-Smad2/pSmad2_c
in compartment: metaid_0000019

metaid_0000068
kinetic law: 799799
product: 799787
reactant: 799775
reactant: 799763
is version of: GO:0006461
fast: false
reversible: true
name: Reaction 4C Formation G2_C
type: Reaction

metaid_0000078
unit: 798913
unit: 798901
name: litrepersecond
type: SBMLUnitsDef

metaid_0000152
constant: true
units: metaid_0000049
value: 2700.0
name: time of SB addition
type: Parameter

metaid_0000028
boundary condition: false
has version: C00562
type: Species
constant: false
is version of: GO:0043234
has version: IPR000786
has only substance units: false
name: pGFP-Smad2/pSmad2_n
initial amount: NaN
in compartment: metaid_0000018
has part: Q15796
initial concentration: 0.0

799108
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

798841
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

799909
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000040
name: pGFP-Smad2/pGFP-Smad2_c
has version: C00562
type: Species
has only substance units: false
constant: false
has version: IPR000786
is version of: GO:0043234
in compartment: metaid_0000019
boundary condition: false
initial concentration: 0.0
has part: Q15796
initial amount: NaN

800029
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000050
kinetic law: 798986
product: 798974
reactant: 798962
is version of: GO:0006913
fast: false
reversible: true
name: Reaction 5A Shuttling S2
type: Reaction

799739
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

798817
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000067
kinetic law: 799751
product: 799739
reactant: 799727
is version of: GO:0006461
fast: false
reversible: true
name: Reaction 4F Formation GG_N
type: Reaction

metaid_0000027
is version of: Q13485
constant: false
boundary condition: false
has only substance units: false
initial concentration: 50.78093897
initial amount: NaN
in compartment: metaid_0000018
name: Smad4_n
type: Species

metaid_0000077
unit: 798889
unit: 798877
unit: 798865
name: pernMpersecond
type: SBMLUnitsDef

798877
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

798901
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

799497
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

799885
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

799144
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000037
is version of: C00562
initial amount: NaN
initial concentration: 0.0
has only substance units: false
constant: false
has version: IPR000786
boundary condition: false
is version of: Q15796
in compartment: metaid_0000019
name: pGFP-Smad2_c
type: Species

799096
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

799653
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

metaid_0000062
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.30
name: Reaction 2B Phosphorylation GS2
product: 799521
reactant: 799509
product: 799533
is version of: GO:0004675
reactant: 799497
kinetic law: 799545

metaid_0000076
unit: 798853
name: persecond
type: SBMLUnitsDef

799557
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

799701
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

799010
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

799617
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

metaid_0000036
boundary condition: false
is version of: Q15796
type: Species
initial concentration: 60.5899176013587
initial amount: NaN
has only substance units: false
has version: IPR000786
constant: false
name: GFP-Smad2_c
in compartment: metaid_0000019

799205
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000042
name: R_act
has version: P36897
has version: Q5T7S2
type: Species
boundary condition: false
initial amount: NaN
constant: false
in compartment: metaid_0000019
has only substance units: false
initial concentration: 0.0
has version: P37173
has version: Q8NER5

metaid_0000016
constant: false
units: metaid_0000075
value: 682.956
name: Kdiss SB (dissociation constant of the SB/receptor interaction)
type: Parameter

799969
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000022
is version of: Q15796
has only substance units: false
initial amount: NaN
initial concentration: 0.0
is version of: C00562
type: Species
in compartment: metaid_0000018
name: pSmad2_n
boundary condition: false
constant: false

metaid_0000056
kinetic law: 799255
product: 799243
reactant: 799230
is version of: GO:0006913
fast: false
reversible: false
name: Reaction 9A Import S22
type: Reaction

799993
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

799156
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000061
kinetic law: 799485
product: 799473
reactant: 799460
reactant: 799448
is version of: GO:0030512
fast: false
reversible: true
name: Reaction 11 Receptor Inhibition
type: Reaction

metaid_0000075
unit: 798841
unit: 798829
name: nM
type: SBMLUnitsDef

798937
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000015
constant: true
units: metaid_0000077
value: 0.07423555020288
name: k_TGFb (rate of TGFb binding to receptors)
type: Parameter

798889
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000035
initial concentration: 0.0
has only substance units: false
type: Species
boundary condition: false
is version of: Q15796
initial amount: NaN
constant: false
in compartment: metaid_0000019
is version of: C00562
name: pSmad2_c

metaid_0000041
boundary condition: true
name: TGFb_c
type: Species
initial concentration: 0.0659999824780232
has version: P01137
initial amount: NaN
constant: true
has version: P10600
in compartment: metaid_0000019
has version: P61812
has only substance units: false

metaid_0000055
kinetic law: 799218
product: 799205
reactant: 799193
is version of: GO:0006913
fast: false
reversible: false
name: Reaction 8A Import S24
type: Reaction

metaid_0000021
is version of: Q15796
constant: false
boundary condition: false
has only substance units: false
initial concentration: 28.514773357617
initial amount: NaN
in compartment: metaid_0000018
name: Smad2_n
type: Species

799243
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

metaid_0000004
constant: true
units: metaid_0000078
value: 5.93E-15
name: kin (import rate for monomeric Smads)
type: Parameter

metaid_0000074
kinetic law: 800053
product: 800041
reactant: 800029
is version of: GO:0006913
fast: false
reversible: false
name: Reaction 8B Import G4
type: Reaction

metaid_0000064
kinetic law: 799641
product: 799629
reactant: 799617
is version of: GO:0006913
fast: false
reversible: true
name: Reaction 5B Shuttling G
type: Reaction

799569
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000014
constant: true
units: metaid_0000076
value: 100.0
name: koff_SB (off-rate of the SB/receptor interaction)
type: Parameter

metaid_0000044
has version: P36897
has version: Q5T7S2
type: Species
initial amount: NaN
name: R_inact
constant: false
boundary condition: false
has version: P37173
in compartment: metaid_0000019
has version: Q8NER5
initial concentration: 0.0
has only substance units: false

metaid_0000034
is version of: Q15796
constant: false
boundary condition: false
has only substance units: false
initial concentration: 60.5899176013587
initial amount: NaN
in compartment: metaid_0000019
name: Smad2_c
type: Species

799340
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000024
has version: IPR000786
constant: false
initial concentration: 0.0
is version of: C00562
boundary condition: false
in compartment: metaid_0000018
is version of: Q15796
has only substance units: false
name: pGFP-Smad2_n
initial amount: NaN
type: Species

metaid_0000054
kinetic law: 799181
product: 799169
reactant: 799156
reactant: 799144
is version of: GO:0006461
fast: false
reversible: true
name: Reaction 3B Formation S24_N
type: Reaction

799593
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000073
kinetic law: 800017
product: 800005
reactant: 799993
is version of: GO:0006913
fast: false
reversible: false
name: Reaction 9B Import G2
type: Reaction

BIOMD0000000173
species: metaid_0000045
parameter: metaid_0000010
parameter: metaid_0000012
species: metaid_0000042
species: metaid_0000038
species: metaid_0000028
reaction: metaid_0000049
parameter: metaid_0000008
name: Schmierer_2008_Smad_Tgfb
reaction: metaid_0000054
reaction: metaid_0000053
reaction: metaid_0000056
length unit: length
species: metaid_0000033
units def: metaid_0000075
species: metaid_0000035
species: metaid_0000025
species: metaid_0000032
volume units: metaid_0000004
is version of: GO:0007179
reaction: metaid_0000061
reaction: metaid_0000072
reaction: metaid_0000063
reaction: metaid_0000071
parameter: metaid_0000014
reaction: metaid_0000069
parameter: metaid_0000013
compartment: metaid_0000019
species: metaid_0000040
reaction: metaid_0000051
is: MODEL0451870146
parameter: metaid_0000004
reaction: metaid_0000059
parameter: metaid_0000005
is described by: http://identifiers.org/pubmed/18443295
rule: metaid_0000046
species: metaid_0000041
species: metaid_0000022
species: metaid_0000034
species: metaid_0000027
species: metaid_0000024
reaction: metaid_0000065
substance units: metaid_0000003
parameter: metaid_0000011
reaction: metaid_0000074
reaction: metaid_0000067
species: metaid_0000044
rule: metaid_0000080
units def: metaid_0000076
reaction: metaid_0000062
reaction: metaid_0000055
reaction: metaid_0000064
species: metaid_0000031
species: metaid_0000037
parameter: metaid_0000151
parameter: metaid_0000009
notes: This sbml file describes the RECI model from: "Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system" by Bernhard Schmierer, Alexander L. Tournier, Paul A. Bates and Caroline S. Hill, Proc Natl Acad Sci U S A. 2008 May 6;105(18):6608-13. All parameter and species names are as in Figure S3 of the original publication. The original model was done in copasi. SB-431542 addition to a concentration of 10000 nM is set at 2700 sec. The initial concentration of SB, the time point of addition and the final concentration can be set by altering the parameters SB_0 , t_SB and SB_end . This model file has been used to reproduce Figures 2D and 5A from the research paper using SBMLodesolver. To get the results for the figures, sum the corresponding concentrations: fig 2D: nuclear EGFP-Smad2 = G_n + pG_n + G2_n + G4_n + 2* GG_n fig 5A (either n or c for nucleus or cytosol): monomeric Smad2 = S2_n/c + G_n/c monomeric P-Smad2 = pS2_n/c + pG_n/c Smad2/Smad4 complexes = S24_n/c + G4_n/c Smad2/Smad2 complexes = S22_n/c + G2_n/c + GG_n/c This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
is version of: hsa04350
parameter: metaid_0000015
parameter: metaid_0000006
units def: metaid_0000078
rule: metaid_0000048
reaction: metaid_0000066
reaction: metaid_0000068
species: metaid_0000021
species: metaid_0000023
parameter: metaid_0000007
parameter: metaid_0000016
species: metaid_0000043
species: metaid_0000030
species: metaid_0000020
species: metaid_0000039
species: metaid_0000036
species: metaid_0000029
type: SBMLModel
curated: true
species: metaid_0000026
reaction: metaid_0000073
units def: metaid_0000003
reaction: metaid_0000070

metaid_0000063
is version of: http://identifiers.org/ec-code/3.1.3.16
name: Reaction 10B Dephos pG Nuc
type: Reaction
fast: false
product: 799581
reversible: false
product: 799593
is version of: GO:0004722
reactant: 799569
reactant: 799557
kinetic law: 799605

metaid_0000013
constant: true
units: metaid_0000077
value: 0.146422317103884
name: kon_SB (on-rate of the SB/receptor interaction)
type: Parameter

798925
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

metaid_0000043
in compartment: metaid_0000019
has version: Q8NER5
has only substance units: false
boundary condition: false
initial concentration: 1.0
has version: P37173
type: Species
initial amount: NaN
constant: false
name: R
has version: P36897
has version: Q5T7S2

metaid_0000033
is version of: Q13485
constant: false
boundary condition: false
has only substance units: false
initial concentration: 50.78103407
initial amount: NaN
in compartment: metaid_0000019
name: Smad4_c
type: Species

799169
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000023
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
has version: IPR000786
is version of: Q15796
constant: false
name: GFP-Smad2_n
in compartment: metaid_0000018
initial concentration: 28.514773357617

799448
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

799304
stoichiometry: 2.0
species: metaid_0000022
type: SpeciesReference

metaid_0000053
kinetic law: 799132
product: 799120
reactant: 799108
reactant: 799096
is version of: GO:0006461
fast: false
reversible: true
name: Reaction 3A Formation S24_C
type: Reaction

ORG:
  orgname: Developmental Signalling Lab, Cancer Research UK London Research Institute
n:
  given: Bernhard
  family: Schmierer

orgname: EMBL-EBI

W3 CDTF: Wed May 16 11:03:54 BST 2012

given: Lukas
family: Endler

W3 CDTF: Wed Jul 30 11:47:57 BST 2008