metaid_0000013
constant: true
value: 0.6
name: pS
type: Parameter

metaid_0000017
constant: true
value: 0.6
name: qE
type: Parameter

metaid_0000007
constant: true
value: 0.16
name: aE
type: Parameter

077690
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000027
is version of: P06400
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.5
in compartment: metaid_0000023
name: R
type: Species

metaid_0000041
reversible: false
modifier: 077798
product: 077762
modifier: 077786
modifier: 077774
kinetic law: 077823
fast: false
name: cycle progression
is version of: GO:0051726
type: Reaction

metaid_0000023
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

077835
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000034
kinetic law: 077378
modifier: 077366
modifier: 077354
reactant: 077342
is version of: GO:0008054
fast: false
reversible: false
name: cycD/CDK4 degradation
type: Reaction

metaid_0000038
is version of: GO:0006461
kinetic law: 077606
reactant: 077546
modifier: 077594
modifier: 077570
product: 077558
modifier: 077582
type: Reaction
reversible: false
fast: false
name: pRB/E2F complex association

metaid_0000003
constant: true
value: 0.4
name: aD
type: Parameter

metaid_0000006
constant: true
value: 0.4
name: dD
type: Parameter

metaid_0000012
constant: true
value: 2.5
name: RT
type: Parameter

metaid_0000016
constant: true
value: 0.096
name: pE
type: Parameter

metaid_0000026
initial concentration: NaN
name: RS
has part: P06400
boundary condition: false
has only substance units: false
constant: false
type: Species
has part: Q01094
in compartment: metaid_0000023
initial amount: 1.0

metaid_0000030
is version of: P06400
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid_0000023
name: RP
type: Species

metaid_0000022
constant: true
value: 0.8
name: qX
type: Parameter

metaid_0000040
kinetic law: 077750
modifier: 077714
modifier: 077702
reactant: 077690
is version of: GO:0043624
fast: false
reversible: false
name: pRB/E2F complex deassociation via cycE/CDK2
type: Reaction

BIOMD0000000168
is part of: hsa04110
parameter: metaid_0000003
is: MODEL3896909694
compartment: metaid_0000023
parameter: metaid_0000007
parameter: metaid_0000013
reaction: metaid_0000037
rule: metaid_0000044
parameter: metaid_0000010
occurs in: http://identifiers.org/taxonomy/2759
species: metaid_0000025
parameter: metaid_0000017
species: metaid_0000024
parameter: metaid_0000043
parameter: metaid_0000004
parameter: metaid_0000014
parameter: metaid_0000008
parameter: metaid_0000018
parameter: metaid_0000020
reaction: metaid_0000042
is described by: http://identifiers.org/pubmed/17886749
length unit: length
reaction: metaid_0000034
species: metaid_0000030
species: metaid_0000029
name: Obeyesekere1999_CellCycle
time units: metaid_0000027
species: metaid_0000028
parameter: metaid_0000011
is version of: GO:0000278
type: SBMLModel
curated: true
reaction: metaid_0000038
area units: metaid_0000005
reaction: metaid_0000040
substance units: metaid_0000003
volume units: metaid_0000004
parameter: metaid_0000015
parameter: metaid_0000005
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
parameter: metaid_0000009
parameter: metaid_0000019
parameter: metaid_0000021
reaction: metaid_0000033
rule: metaid_0000031
rule: metaid_0000032
reaction: metaid_0000035
parameter: metaid_0000006
notes: The model reproduces the time profiles of the different species depicted in Fig 3a of the paper. Model successfully reproduced using MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
parameter: metaid_0000012
parameter: metaid_0000022
reaction: metaid_0000036
created:
  W3 CDTF: Sun Mar 16 19:31:22 GMT 2008
species: metaid_0000027
species: metaid_0000026
reaction: metaid_0000039
reaction: metaid_0000041
parameter: metaid_0000016
modified:
  W3 CDTF: Thu Aug 09 17:26:41 BST 2012

metaid_0000035
kinetic law: 077414
modifier: 077402
product: 077390
is version of: GO:0006412
fast: false
reversible: false
name: cycE/CDK2 synthesis
type: Reaction

metaid_0000039
kinetic law: 077678
modifier: 077642
modifier: 077630
reactant: 077618
is version of: GO:0043624
fast: false
reversible: false
name: pRB/E2F complex deassociation via cycD/CDK4
type: Reaction

077390
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

077546
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000015
constant: true
value: 0.6
name: qD
type: Parameter

metaid_0000009
constant: true
value: 1.5
name: theta
type: Parameter

metaid_0000011
constant: true
value: 0.48
name: pX
type: Parameter

metaid_0000043
constant: false
value: 0.0
type: Parameter

metaid_0000025
is version of: P24864
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.6
in compartment: metaid_0000023
name: E
type: Species

metaid_0000029
is version of: Q01094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid_0000023
name: E2F
type: Species

metaid_0000033
kinetic law: 077330
product: 077317
is version of: GO:0006412
fast: false
reversible: false
name: cycD/CDK4 synthesis
type: Reaction

metaid_0000020
constant: true
value: 0.528
name: g
type: Parameter

077317
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000036
kinetic law: 077462
modifier: 077450
modifier: 077438
reactant: 077426
is version of: GO:0008054
fast: false
reversible: false
name: cycE/CDK2 degradation
type: Reaction

metaid_0000019
constant: true
value: 0.2
name: f
type: Parameter

metaid_0000005
constant: true
value: 6.3
name: GF
type: Parameter

077762
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

077426
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

metaid_0000014
constant: true
value: 0.48
name: pD
type: Parameter

metaid_0000008
constant: true
value: 0.9
name: af
type: Parameter

metaid_0000042
kinetic law: 077859
modifier: 077847
reactant: 077835
is version of: GO:0051726
fast: false
reversible: false
name: cycle break
type: Reaction

metaid_0000010
constant: true
value: 0.2
name: dE
type: Parameter

077474
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

077618
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000024
is version of: P24385
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.1
in compartment: metaid_0000023
name: D
type: Species

metaid_0000028
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.7
in compartment: metaid_0000023
name: X
type: Species

077558
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000021
constant: true
value: 1.04
name: dX
type: Parameter

metaid_0000037
kinetic law: 077534
modifier: 077498
modifier: 077486
product: 077474
is version of: GO:0016311
fast: false
reversible: false
name: pRB-p dephosphorilation
type: Reaction

077342
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000004
constant: true
value: 0.05
name: k
type: Parameter

metaid_0000018
constant: true
value: 0.08
name: aX
type: Parameter