metaid_0000024
kinetic law: 038064
reactant: 038052
is version of: GO:0044257
fast: false
reversible: true
name: Mdm2 degradation
type: Reaction

metaid_0000008
constant: true
value: 0.1
type: Parameter

037980
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

037871
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

metaid_0000004
constant: true
value: 1.0
type: Parameter

metaid_0000018
kinetic law: 038040
product: 038028
reactant: 038016
is version of: GO:0006412
fast: false
reversible: false
name: Mdm2 synthesis from precursor
type: Reaction

metaid_0000014
kinetic law: 037932
reactant: 037919
is version of: GO:0042176
fast: false
reversible: false
name: Mdm2 independent p53 degradation
type: Reaction

metaid_0000023
constant: true
value: 0.1
type: Parameter

037883
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

037944
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

metaid_0000007
constant: true
value: 0.4
type: Parameter

metaid_0000003
constant: true
value: 0.3
type: Parameter

metaid_0000020
unit: 037883
name: hours
type: SBMLUnitsDef

metaid_0000013
kinetic law: 037907
product: 037895
is version of: GO:0006412
fast: false
reversible: false
name: p53 production
type: Reaction

metaid_0000006
constant: true
value: 3.2
type: Parameter

BIOMD0000000159
occurs in: http://identifiers.org/taxonomy/9606
created:
  W3 CDTF: Thu Jan 10 17:38:04 GMT 2008
parameter: metaid_0000003
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
species: metaid_0000011
compartment: metaid_0000009
reaction: metaid_0000024
reaction: metaid_0000013
type: SBMLModel
parameter: metaid_0000005
reaction: metaid_0000015
volume units: metaid_0000084
parameter: metaid_0000007
parameter: metaid_0000004
time units: metaid_0000020
species: metaid_0000022
parameter: metaid_0000023
reaction: metaid_0000014
modified:
  W3 CDTF: Thu Jul 05 15:47:24 BST 2012
notes: The model reproduces the time profile of p53 and Mdm2 as depicted in Fig 6B of the plot for model 1. Results obtained on MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
is part of: GO:0042771
parameter: metaid_0000006
is part of: hsa04115
area units: metaid_0000005
units def: metaid_0000019
reaction: metaid_0000016
is: MODEL0076281110
length unit: length
parameter: metaid_0000008
substance units: metaid_0000019
name: Zatorsky2006_p53_Model1
units def: metaid_0000020
curated: true
reaction: metaid_0000018
species: metaid_0000012
is described by: http://identifiers.org/pubmed/16773083

metaid_0000012
is version of: Q00987
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000009
name: Mdm2
type: Species

037919
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

metaid_0000016
kinetic law: 038004
modifier: 037992
product: 037980
is version of: GO:0006351
fast: false
reversible: false
name: p53 dependent Mdm2 precursor production
type: Reaction

038028
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

038016
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000019
unit: 037871
name: dimensionless
type: SBMLUnitsDef

037895
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

metaid_0000009
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

metaid_0000015
kinetic law: 037968
modifier: 037956
reactant: 037944
is version of: GO:0042176
fast: false
reversible: false
name: Mdm2 dependent p53 degradation
type: Reaction

metaid_0000005
constant: true
value: 0.0
type: Parameter

metaid_0000022
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000009
name: precursor Mdm2
type: Species

038052
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

metaid_0000011
is version of: P04637
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000009
name: p53
type: Species