metaid_0000209
kinetic law: 049825
product: 049813
reactant: 049801
reactant: 049789
is version of: GO:0005515
fast: false
reversible: true
name: PP2-STAT3N complex formation
type: Reaction

metaid_0000053
constant: true
value: 0.01
type: Parameter

048695
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

050113
stoichiometry: 1.0
species: metaid_0000121
type: SpeciesReference

048481
stoichiometry: 1.0
species: metaid_0000112
type: SpeciesReference

050389
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

050497
stoichiometry: 1.0
species: metaid_0000143
type: SpeciesReference

metaid_0000067
constant: true
value: 0.023
type: Parameter

051364
stoichiometry: 1.0
species: metaid_0000156
type: SpeciesReference

050197
stoichiometry: 1.0
species: metaid_0000142
type: SpeciesReference

050401
stoichiometry: 1.0
species: metaid_0000128
type: SpeciesReference

metaid_0000040
constant: true
value: 6.0
type: Parameter

metaid_0000054
constant: true
value: 5.0E-4
type: Parameter

049176
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

049645
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000068
constant: true
value: 2.2E-4
type: Parameter

051015
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

050582
stoichiometry: 1.0
species: metaid_0000145
type: SpeciesReference

metaid_0000051
constant: true
value: 0.001
type: Parameter

051412
stoichiometry: 1.0
species: metaid_0000156
type: SpeciesReference

050859
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

048683
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

metaid_0000041
constant: true
value: 0.06
type: Parameter

049020
stoichiometry: 1.0
species: metaid_0000125
type: SpeciesReference

049837
stoichiometry: 1.0
species: metaid_0000139
type: SpeciesReference

metaid_0000079
constant: true
value: 1.0
type: Parameter

051532
stoichiometry: 1.0
species: metaid_0000177
type: SpeciesReference

metaid_0000069
constant: true
value: 0.5
type: Parameter

metaid_0000042
constant: true
value: 0.5
type: Parameter

050305
stoichiometry: 1.0
species: metaid_0000125
type: SpeciesReference

049164
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

metaid_0000052
constant: true
value: 5.0E-4
type: Parameter

051027
stoichiometry: 1.0
species: metaid_0000165
type: SpeciesReference

050594
stoichiometry: 1.0
species: metaid_0000147
type: SpeciesReference

metaid_0000250
is: GO:0005634
constant: true
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

048610
stoichiometry: 1.0
species: metaid_0000113
type: SpeciesReference

metaid_0000057
constant: true
value: 0.0015
type: Parameter

050473
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

049068
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000240
type: Reaction
name: MEK-P-Raf complex dissociation
is: http://identifiers.org/ec-code/2.7.11.1
product: 051207
product: 051219
reactant: 051195
reversible: false
fast: false
is: GO:0004672
kinetic law: 051231

metaid_0000043
constant: true
value: 0.005
type: Parameter

049032
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000063
constant: true
value: 0.03
type: Parameter

metaid_0000077
constant: true
value: 0.0079
type: Parameter

049717
stoichiometry: 2.0
species: metaid_0000136
type: SpeciesReference

051448
stoichiometry: 1.0
species: metaid_0000160
type: SpeciesReference

049801
stoichiometry: 1.0
species: metaid_0000136
type: SpeciesReference

metaid_0000058
constant: true
value: 0.0045
type: Parameter

049981
stoichiometry: 1.0
species: metaid_0000141
type: SpeciesReference

metaid_0000044
constant: true
value: 0.001
type: Parameter

051388
stoichiometry: 1.0
species: metaid_0000173
type: SpeciesReference

metaid_0000064
constant: true
value: 0.064
type: Parameter

050425
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000078
constant: true
value: 0.4
type: Parameter

051292
stoichiometry: 1.0
species: metaid_0000157
type: SpeciesReference

050485
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000055
constant: true
value: 0.01
type: Parameter

048493
stoichiometry: 1.0
species: metaid_0000110
type: SpeciesReference

metaid_0000045
constant: true
value: 0.2
type: Parameter

metaid_0000065
constant: true
value: 0.015
type: Parameter

051436
stoichiometry: 1.0
species: metaid_0000173
type: SpeciesReference

049260
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

050835
stoichiometry: 1.0
species: metaid_0000171
type: SpeciesReference

049813
stoichiometry: 1.0
species: metaid_0000163
type: SpeciesReference

049044
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

048532
stoichiometry: 1.0
species: metaid_0000112
type: SpeciesReference

metaid_0000075
constant: true
value: 0.3
type: Parameter

049633
stoichiometry: 1.0
species: metaid_0000124
type: SpeciesReference

metaid_0000056
constant: true
value: 0.55
type: Parameter

051592
stoichiometry: 1.0
species: metaid_0000159
type: SpeciesReference

049092
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

metaid_0000251
unit: 048388
name: nano mole
type: SBMLUnitsDef

050570
stoichiometry: 1.0
species: metaid_0000146
type: SpeciesReference

metaid_0000046
constant: true
value: 0.2
type: Parameter

050329
stoichiometry: 1.0
species: metaid_0000125
type: SpeciesReference

049560
stoichiometry: 1.0
species: metaid_0000131
type: SpeciesReference

metaid_0000066
constant: true
value: 1.3
type: Parameter

049140
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

050185
stoichiometry: 1.0
species: metaid_0000124
type: SpeciesReference

metaid_0000076
constant: true
value: 0.021
type: Parameter

049308
stoichiometry: 1.0
species: metaid_0000121
type: SpeciesReference

metaid_0000147
has part: Q61411
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: Raf-Ras-GTP
type: Species

048840
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

metaid_0000133
has part: P42227
has part: P52332
initial amount: NaN
has only substance units: false
has part: P22272
in compartment: metaid_0000108
name: (IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3-SHP2
type: Species
constant: false
has part: P08505
initial concentration: 0.0
has part: O35718
has part: P35235
has part: Q6PDI9
boundary condition: false

metaid_0000073
constant: true
value: 0.03
type: Parameter

049116
stoichiometry: 1.0
species: metaid_0000129
type: SpeciesReference

metaid_0000034
constant: true
value: 0.1
type: Parameter

051147
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

051219
stoichiometry: 1.0
species: metaid_0000156
type: SpeciesReference

049789
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

metaid_0000020
constant: true
value: 0.2
type: Parameter

050534
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000146
is version of: Q99N57
constant: false
boundary condition: false
has only substance units: false
initial concentration: 67.0
initial amount: NaN
in compartment: metaid_0000108
name: Raf
type: Species

metaid_0000074
constant: true
value: 0.0429
type: Parameter

metaid_0000060
constant: true
value: 0.55
type: Parameter

metaid_0000132
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: STAT3N
type: Species

050823
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

metaid_0000033
constant: true
value: 0.02
type: Parameter

050257
stoichiometry: 1.0
species: metaid_0000142
type: SpeciesReference

metaid_0000145
has part: Q61411
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: Ras-GTP
type: Species

metaid_0000061
constant: true
value: 0.01
type: Parameter

048852
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

050161
stoichiometry: 1.0
species: metaid_0000121
type: SpeciesReference

metaid_0000071
constant: true
value: 0.001
type: Parameter

metaid_0000135
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: STAT3Nast-STAT3Nast
type: Species

050077
stoichiometry: 1.0
species: metaid_0000121
type: SpeciesReference

metaid_0000032
constant: true
value: 0.05
type: Parameter

051159
stoichiometry: 1.0
species: metaid_0000153
type: SpeciesReference

metaid_0000022
constant: true
value: 0.1
type: Parameter

049128
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

049705
stoichiometry: 1.0
species: metaid_0000135
type: SpeciesReference

051243
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

050811
stoichiometry: 1.0
species: metaid_0000147
type: SpeciesReference

metaid_0000062
constant: true
value: 0.0214
type: Parameter

metaid_0000144
has part: Q62245
initial concentration: 0.0
has part: P35235
has part: P08505
has part: P22272
has part: Q6PDI9
initial amount: NaN
has part: Q60631
in compartment: metaid_0000108
has only substance units: false
name: (IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GDP
type: Species
boundary condition: false
has part: Q61411
constant: false
has part: P52332

metaid_0000072
constant: true
value: 0.0053
type: Parameter

050522
stoichiometry: 1.0
species: metaid_0000144
type: SpeciesReference

metaid_0000134
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: STAT3Cast-STAT3Cast
type: Species

048924
stoichiometry: 1.0
species: metaid_0000121
type: SpeciesReference

metaid_0000031
constant: true
value: 0.2
type: Parameter

050919
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

050715
stoichiometry: 1.0
species: metaid_0000171
type: SpeciesReference

metaid_0000021
constant: true
value: 0.02
type: Parameter

metaid_0000010
constant: true
value: 0.04
type: Parameter

049669
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

049765
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

050209
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000030
constant: true
value: 2.0E-7
type: Parameter

metaid_0000137
constant: false
boundary condition: false
has only substance units: false
initial concentration: 60.0
initial amount: NaN
in compartment: metaid_0000250
name: PP2
type: Species

049452
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

051340
stoichiometry: 1.0
species: metaid_0000158
type: SpeciesReference

metaid_0000157
is version of: P63085
constant: false
boundary condition: false
has only substance units: false
initial concentration: 35000.0
initial amount: NaN
in compartment: metaid_0000108
name: ERK
type: Species

metaid_0000136
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: STAT3Nast
type: Species

metaid_0000090
constant: true
value: 0.058
type: Parameter

050727
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000070
constant: true
value: 1.0E-4
type: Parameter

051544
stoichiometry: 1.0
species: metaid_0000176
type: SpeciesReference

049849
stoichiometry: 1.0
species: metaid_0000132
type: SpeciesReference

048936
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

051255
stoichiometry: 1.0
species: metaid_0000156
type: SpeciesReference

metaid_0000050
constant: true
value: 400.0
type: Parameter

metaid_0000156
is version of: Q3TMJ8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: MEK-PP
type: Species

051400
stoichiometry: 1.0
species: metaid_0000159
type: SpeciesReference

051207
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

049753
stoichiometry: 1.0
species: metaid_0000135
type: SpeciesReference

metaid_0000159
is version of: P63085
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: ERK-P
type: Species

048996
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

049909
stoichiometry: 1.0
species: metaid_0000132
type: SpeciesReference

metaid_0000149
is version of: Q99N57
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: Rafast
type: Species

050053
stoichiometry: 1.0
species: metaid_0000170
type: SpeciesReference

051352
stoichiometry: 1.0
species: metaid_0000159
type: SpeciesReference

metaid_0000169
is version of: P52332
constant: false
boundary condition: false
has only substance units: false
initial concentration: 12.0
initial amount: NaN
in compartment: metaid_0000108
name: JAK
type: Species

049188
stoichiometry: 1.0
species: metaid_0000131
type: SpeciesReference

metaid_0000139
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: STAT3N-STAT3Nast
type: Species

W3 CDTF: Thu Jul 05 17:44:32 BST 2012

051556
stoichiometry: 1.0
species: metaid_0000159
type: SpeciesReference

050739
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

051267
stoichiometry: 1.0
species: metaid_0000168
type: SpeciesReference

049380
stoichiometry: 0.5
species: metaid_0000134
type: SpeciesReference

metaid_0000148
has part: Q99N57
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: Rafast-Phosp1
type: Species

metaid_0000168
has part: Q3TMJ8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: MEK-PP-Phosp2
type: Species

048948
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

050546
stoichiometry: 1.0
species: metaid_0000145
type: SpeciesReference

metaid_0000158
in compartment: metaid_0000108
constant: false
initial amount: NaN
has part: Q3TMJ8
name: ERK-MEK-PP
boundary condition: false
initial concentration: 0.0
has only substance units: false
type: Species
has part: P63085

metaid_0000138
has part: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: PP2-STAT3Nast-STAT3Nast
type: Species

metaid_0000152
boundary condition: false
initial concentration: 0.0
type: Species
has part: Q3TMJ8
in compartment: metaid_0000108
initial amount: NaN
has part: Q99N57
has only substance units: false
name: MEK-Rafast
constant: false

050245
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

metaid_0000100
constant: true
value: 1.1E-4
type: Parameter

metaid_0000166
has only substance units: false
name: (IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GTP
has part: Q61411
boundary condition: false
has part: P35235
has part: Q60631
has part: P22272
in compartment: metaid_0000108
constant: false
initial amount: NaN
initial concentration: 0.0
has part: P52332
type: Species
has part: P08505
has part: Q62245
has part: Q6PDI9

049344
stoichiometry: 1.0
species: metaid_0000113
type: SpeciesReference

metaid_0000092
constant: true
value: 0.5
type: Parameter

metaid_0000027
constant: true
value: 0.1
type: Parameter

metaid_0000120
has only substance units: false
name: (IL6-gp80-gp130-JAK)ast2-STAT3Cast
in compartment: metaid_0000108
type: Species
initial concentration: 0.0
constant: false
initial amount: NaN
has part: P42227
has part: Q6PDI9
has part: P08505
has part: P22272
has part: P52332
boundary condition: false

050955
stoichiometry: 1.0
species: metaid_0000152
type: SpeciesReference

metaid_0000013
constant: true
value: 0.003
type: Parameter

metaid_0000193
is: GO:0043624
kinetic law: 049104
fast: false
name: IL6-gp80-gp130-JAK-SHP2-Grb2-SOS dissociation
is: http://identifiers.org/ec-code/2.7.10.2
product: 049080
product: 049092
type: Reaction
is: GO:0004713
reversible: true
reactant: 049068

metaid_0000110
initial concentration: 0.0
has part: P08505
name: IL6-gp80
boundary condition: false
has part: P22272
has only substance units: false
in compartment: metaid_0000108
constant: false
initial amount: NaN
type: Species

048900
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

metaid_0000082
constant: true
value: 0.0717
type: Parameter

050281
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

metaid_0000153
is version of: Q3TMJ8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: MEK-P
type: Species

metaid_0000101
constant: true
value: 6.7
type: Parameter

metaid_0000167
is version of: Q6PDI9
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.8
initial amount: NaN
in compartment: metaid_0000108
name: gp130
type: Species

metaid_0000028
constant: true
value: 2.45E-4
type: Parameter

048972
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

metaid_0000091
constant: true
value: 2.5E-4
type: Parameter

metaid_0000121
is version of: O35718
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: SOCS3
type: Species

050666
stoichiometry: 1.0
species: metaid_0000128
type: SpeciesReference

metaid_0000014
constant: true
value: 0.008
type: Parameter

metaid_0000192
kinetic law: 049056
product: 049044
product: 049032
reactant: 049020
is version of: GO:0043624
fast: false
reversible: true
name: IL6-gp80-gp130-JAK SHP2 Grb2 dissociation
type: Reaction

048647
stoichiometry: 1.0
species: metaid_0000113
type: SpeciesReference

metaid_0000111
has part: P08505
initial amount: NaN
has part: P22272
constant: false
has only substance units: false
type: Species
has part: Q6PDI9
has part: P52332
boundary condition: false
in compartment: metaid_0000108
name: IL6-gp80-gp130-JAK
initial concentration: 0.0

metaid_0000081
constant: true
value: 7.0E-4
type: Parameter

051111
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

051051
stoichiometry: 1.0
species: metaid_0000154
type: SpeciesReference

metaid_0000229
kinetic law: 050703
product: 050691
product: 050679
reactant: 050666
is version of: GO:0043623
fast: false
reversible: true
name: SHP2-Grb2-SOS dissociation
type: Reaction

metaid_0000154
has part: Q3TMJ8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: MEK-P-Phosp2
type: Species

049332
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

049248
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

metaid_0000164
has part: P22272
has part: P52332
name: (IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3
has part: Q6PDI9
has only substance units: false
constant: false
type: Species
initial concentration: 0.0
has part: O35718
boundary condition: false
has part: P08505
initial amount: NaN
in compartment: metaid_0000108

050233
stoichiometry: 1.0
species: metaid_0000175
type: SpeciesReference

metaid_0000102
constant: true
value: 0.3
type: Parameter

050293
stoichiometry: 1.0
species: metaid_0000142
type: SpeciesReference

metaid_0000195
kinetic law: 049200
product: 049188
reactant: 049176
reactant: 049164
is version of: GO:0046983
fast: false
reversible: true
name: STAT3C dimerization
type: Reaction

metaid_0000122
name: (IL6-gp80-gp130-JAK)ast2-SOCS3
has part: Q6PDI9
initial amount: NaN
has part: P22272
has part: O35718
has part: P52332
initial concentration: 0.0
boundary condition: false
type: Species
constant: false
has part: P08505
has only substance units: false
in compartment: metaid_0000108

metaid_0000094
constant: true
value: 0.0143
type: Parameter

metaid_0000029
constant: true
value: 0.003
type: Parameter

metaid_0000039
constant: true
value: 340.0
type: Parameter

metaid_0000011
constant: true
value: 0.2
type: Parameter

metaid_0000249
kinetic law: 051665
product: 051653
reactant: 051641
reactant: 051629
is version of: GO:0005515
fast: false
reversible: true
name: ERK-PP-Phosp3 formation
type: Reaction

049464
stoichiometry: 1.0
species: metaid_0000134
type: SpeciesReference

metaid_0000080
constant: true
value: 1.0
type: Parameter

metaid_0000155
constant: false
boundary condition: false
has only substance units: false
initial concentration: 67.0
initial amount: NaN
in compartment: metaid_0000108
name: Phosp2
type: Species

metaid_0000103
constant: true
value: 0.27
type: Parameter

metaid_0000165
has part: Q99N57
boundary condition: false
has only substance units: false
constant: false
has part: Q3TMJ8
type: Species
initial amount: NaN
in compartment: metaid_0000108
name: MEK-P-Rafast
initial concentration: 0.0

048888
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

048659
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

metaid_0000123
has part: P08505
initial amount: NaN
has part: P22272
type: Species
constant: false
has only substance units: false
has part: Q6PDI9
in compartment: metaid_0000108
has part: P52332
name: (IL6-gp80-gp130-JAK)ast2-SHP2ast
initial concentration: 0.0
boundary condition: false
has part: P35235

metaid_0000093
constant: true
value: 2.9
type: Parameter

048707
stoichiometry: 1.0
species: metaid_0000113
type: SpeciesReference

metaid_0000194
kinetic law: 049152
product: 049140
product: 049128
reactant: 049116
is version of: GO:0032516
fast: false
reversible: false
name: PP1-STAT3Cast dissociation
type: Reaction

048984
stoichiometry: 1.0
species: metaid_0000124
type: SpeciesReference

051460
stoichiometry: 1.0
species: metaid_0000156
type: SpeciesReference

metaid_0000012
constant: true
value: 0.005
type: Parameter

metaid_0000162
is version of: Q62245
constant: false
boundary condition: false
has only substance units: false
initial concentration: 34.0
initial amount: NaN
in compartment: metaid_0000108
name: SOS
type: Species

050775
stoichiometry: 1.0
species: metaid_0000146
type: SpeciesReference

metaid_0000023
constant: true
value: 0.3
type: Parameter

metaid_0000237
kinetic law: 051087
product: 051075
product: 051063
reactant: 051051
is version of: GO:0032516
fast: false
reversible: false
name: MEK-P-Phosp2 dissociation
type: Reaction

metaid_0000183
kinetic law: 048635
product: 048623
reactant: 048610
is version of: GO:0043624
fast: false
reversible: false
name: IL6-gp80-gp130-JAK dimer dissociation
type: Reaction

049476
stoichiometry: 1.0
species: metaid_0000174
type: SpeciesReference

metaid_0000227
kinetic law: 050606
product: 050594
reactant: 050582
reactant: 050570
is version of: GO:0005515
fast: false
reversible: true
name: Ras-GTP-Raf complex formation
type: Reaction

metaid_0000037
constant: true
value: 0.005
type: Parameter

048804
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

metaid_0000017
constant: true
value: 0.005
type: Parameter

050017
stoichiometry: 1.0
species: metaid_0000141
type: SpeciesReference

metaid_0000210
kinetic law: 049873
product: 049861
product: 049849
reactant: 049837
is version of: GO:0043624
fast: false
reversible: true
name: STAT3N dimer dissociation
type: Reaction

051195
stoichiometry: 1.0
species: metaid_0000165
type: SpeciesReference

metaid_0000096
constant: true
value: 1.1E-4
type: Parameter

metaid_0000114
type: Species
has part: Q6PDI9
has part: P52332
boundary condition: false
has part: P22272
initial concentration: 0.0
name: (IL6-gp80-gp130-JAK)_ast2
has part: P08505
has only substance units: false
initial amount: NaN
in compartment: metaid_0000108
constant: false

049861
stoichiometry: 1.0
species: metaid_0000136
type: SpeciesReference

metaid_0000086
constant: true
value: 3.5
type: Parameter

050931
stoichiometry: 1.0
species: metaid_0000152
type: SpeciesReference

metaid_0000142
is version of: Q60631
constant: false
boundary condition: false
has only substance units: false
initial concentration: 85.0
initial amount: NaN
in compartment: metaid_0000108
name: Grb2
type: Species

metaid_0000124
is version of: P35235
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: SHP2ast
type: Species

050871
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

metaid_0000200
kinetic law: 049440
product: 049428
reactant: 049416
reactant: 049404
is version of: GO:0005515
fast: false
reversible: true
name: IL6-gp80-gp130-JAK STAT3Cast complex formation
type: Reaction

metaid_0000003
constant: true
value: 0.38
type: Parameter

049320
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000163
has part: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: PP2-STAT3Nast
type: Species

metaid_0000182
kinetic law: 048597
product: 048585
reactant: 048571
is version of: GO:0042803
fast: false
reversible: false
name: IL6-gp80-gp130-JAK dimerization
type: Reaction

metaid_0000024
constant: true
value: 9.0E-4
type: Parameter

metaid_0000238
kinetic law: 051135
product: 051123
product: 051111
reactant: 051099
is version of: GO:0032516
fast: false
reversible: false
name: MEK-PP-Phosp2 dissociation
type: Reaction

metaid_0000115
has only substance units: false
has part: P22272
boundary condition: false
constant: false
has part: P35235
has part: Q6PDI9
has part: P08505
initial concentration: 0.0
name: (IL6-gp80-gp130-JAK)ast2-JAK
type: Species
has part: P52332
in compartment: metaid_0000108
initial amount: NaN

metaid_0000228
kinetic law: 050654
product: 050642
reactant: 050630
reactant: 050618
is version of: GO:0043623
fast: false
reversible: true
name: Complex formation
type: Reaction

metaid_0000018
constant: true
value: 0.5
type: Parameter

049897
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

048876
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000038
constant: true
value: 1.7
type: Parameter

metaid_0000095
constant: true
value: 0.8
type: Parameter

metaid_0000125
has part: P52332
initial concentration: 0.0
has part: Q60631
boundary condition: false
type: Species
has part: P35235
constant: false
has part: P08505
has part: P22272
name: (IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2
has only substance units: false
in compartment: metaid_0000108
has part: Q6PDI9
initial amount: NaN

metaid_0000143
has part: Q61411
constant: false
boundary condition: false
has only substance units: false
initial concentration: 19000.0
initial amount: NaN
in compartment: metaid_0000108
name: Ras-GDP
type: Species

metaid_0000085
constant: true
value: 0.001833
type: Parameter

metaid_0000004
constant: true
value: 0.1
type: Parameter

049548
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

metaid_0000239
kinetic law: 051183
product: 051171
reactant: 051159
reactant: 051147
is version of: GO:0005515
fast: false
reversible: true
name: MEK-P-Phosp2 complex formation
type: Reaction

metaid_0000181
kinetic law: 048558
modifier: 048546
product: 048532
reactant: 048519
is version of: GO:0005515
fast: false
reversible: false
name: gp130-JAK complex formation
type: Reaction

metaid_0000126
name: SHP2ast-Grb2
has part: P35235
initial concentration: 0.0
boundary condition: false
initial amount: NaN
has part: Q60631
has only substance units: false
constant: false
type: Species
in compartment: metaid_0000108

metaid_0000025
constant: true
value: 0.3
type: Parameter

050907
stoichiometry: 1.0
species: metaid_0000151
type: SpeciesReference

metaid_0000005
constant: true
value: 0.05
type: Parameter

050029
stoichiometry: 1.0
species: metaid_0000170
type: SpeciesReference

metaid_0000150
constant: false
boundary condition: false
has only substance units: false
initial concentration: 67.0
initial amount: NaN
in compartment: metaid_0000108
name: Phosp1
type: Species

050763
stoichiometry: 1.0
species: metaid_0000148
type: SpeciesReference

metaid_0000160
is version of: P63085
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: ERK-PP
type: Species

metaid_0000035
constant: true
value: 0.001
type: Parameter

metaid_0000225
kinetic law: 050509
product: 050497
product: 050485
reactant: 050473
is version of: GO:0043624
fast: false
reversible: true
name: Complex dissociation
type: Reaction

metaid_0000171
has part: Q61411
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: Ras-GTPast
type: Species

050618
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

metaid_0000112
has part: Q6PDI9
has part: P52332
constant: false
type: Species
boundary condition: false
initial concentration: 0.0
has only substance units: false
in compartment: metaid_0000108
name: gp130-JAK
initial amount: NaN

metaid_0000130
constant: false
boundary condition: false
has only substance units: false
initial concentration: 50.0
initial amount: NaN
in compartment: metaid_0000108
name: PP1
type: Species

metaid_0000084
constant: true
value: 0.011
type: Parameter

metaid_0000098
constant: true
value: 16.0
type: Parameter

050883
stoichiometry: 1.0
species: metaid_0000148
type: SpeciesReference

metaid_0000191
kinetic law: 049008
product: 048996
product: 048984
reactant: 048972
is version of: GO:0043624
fast: false
reversible: true
name: IL6-gp80-gp130-JAK -SHP2 dimer dissociation
type: Reaction

metaid_0000212
product: 049945
reactant: 049933
type: Reaction
kinetic law: 049969
product: 049957
is version of: GO:0043624
reversible: false
fast: false
name: PP2-STAT3N dimer dissociation
is version of: GO:0032516

BIOMD0000000151
species: metaid_0000151
reaction: metaid_0000241
reaction: metaid_0000195
species: metaid_0000142
species: metaid_0000115
parameter: metaid_0000021
parameter: metaid_0000062
reaction: metaid_0000213
reaction: metaid_0000233
parameter: metaid_0000055
species: metaid_0000163
parameter: metaid_0000026
species: metaid_0000127
parameter: metaid_0000019
species: metaid_0000112
parameter: metaid_0000050
reaction: metaid_0000201
reaction: metaid_0000221
parameter: metaid_0000043
reaction: metaid_0000209
parameter: metaid_0000084
species: metaid_0000160
parameter: metaid_0000014
parameter: metaid_0000077
parameter: metaid_0000042
parameter: metaid_0000007
name: Singh2006_IL6_Signal_Transduction
parameter: metaid_0000048
species: metaid_0000124
parameter: metaid_0000006
reaction: metaid_0000194
reaction: metaid_0000243
parameter: metaid_0000065
species: metaid_0000144
reaction: metaid_0000185
reaction: metaid_0000224
parameter: metaid_0000099
species: metaid_0000120
reaction: metaid_0000215
parameter: metaid_0000031
parameter: metaid_0000029
parameter: metaid_0000057
occurs in: BTO:0000759
substance units: metaid_0000251
parameter: metaid_0000100
reaction: metaid_0000182
parameter: metaid_0000094
reaction: metaid_0000212
parameter: metaid_0000087
reaction: metaid_0000238
reaction: metaid_0000203
parameter: metaid_0000045
occurs in: BTO:0000575
parameter: metaid_0000060
species: metaid_0000158
parameter: metaid_0000086
parameter: metaid_0000009
parameter: metaid_0000024
parameter: metaid_0000103
is described by: http://identifiers.org/pubmed/16752369
reaction: metaid_0000188
volume units: metaid_0000084
reaction: metaid_0000242
species: metaid_0000154
reaction: metaid_0000218
species: metaid_0000118
parameter: metaid_0000022
parameter: metaid_0000012
parameter: metaid_0000075
species: metaid_0000122
length unit: length
species: metaid_0000175
reaction: metaid_0000230
parameter: metaid_0000039
parameter: metaid_0000090
curated: true
species: metaid_0000138
reaction: metaid_0000192
parameter: metaid_0000070
parameter: metaid_0000010

metaid_0000015
constant: true
value: 0.8
type: Parameter

050679
stoichiometry: 1.0
species: metaid_0000124
type: SpeciesReference

049224
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

metaid_0000026
constant: true
value: 9.0E-4
type: Parameter

048441
stoichiometry: 1.0
species: metaid_0000110
type: SpeciesReference

metaid_0000180
kinetic law: 048506
product: 048493
product: 048481
reactant: 048467
is version of: GO:0043624
fast: false
reversible: false
name: IL6-gp80-gp130-JAK dissociation
type: Reaction

metaid_0000127
has part: P22272
has only substance units: false
has part: P35235
has part: Q6PDI9
initial concentration: 0.0
constant: false
boundary condition: false
name: (IL6-gp80-gp130-JAK)ast2-SHP2-Grb2
type: Species
has part: P08505
has part: Q60631
in compartment: metaid_0000108
has part: P52332
initial amount: NaN

051123
stoichiometry: 1.0
species: metaid_0000153
type: SpeciesReference

metaid_0000006
constant: true
value: 0.1
type: Parameter

metaid_0000161
is version of: P63085
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: ERK-P-Phosp3
type: Species

metaid_0000016
constant: true
value: 0.4
type: Parameter

metaid_0000151
is version of: Q3TMJ8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 41667.0
initial amount: NaN
in compartment: metaid_0000108
name: MEK
type: Species

metaid_0000036
constant: true
value: 0.2
type: Parameter

metaid_0000226
kinetic law: 050558
product: 050546
product: 050534
reactant: 050522
is version of: GO:0032856
fast: false
reversible: true
name: Complex dissociation
type: Reaction

metaid_0000170
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: Mrna-SOCS3C
type: Species

051484
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

metaid_0000131
has part: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: STAT3C-STAT3Cast
type: Species

metaid_0000083
constant: true
value: 0.2
type: Parameter

metaid_0000113
boundary condition: false
initial concentration: 0.0
type: Species
constant: false
has part: P08505
has part: P22272
name: (IL6-gp80-gp130-JAK)2
has only substance units: false
initial amount: NaN
in compartment: metaid_0000108
has part: Q6PDI9
has part: P52332

metaid_0000190
kinetic law: 048960
product: 048948
reactant: 048936
reactant: 048924
is version of: GO:0005515
fast: false
reversible: true
name: IL6-gp80-gp130-JAK -SOCS3 complex formation
type: Reaction

metaid_0000097
constant: true
value: 0.033
type: Parameter

049536
stoichiometry: 1.0
species: metaid_0000174
type: SpeciesReference

metaid_0000211
type: Reaction
fast: false
reactant: 049885
is version of: GO:0032516
product: 049897
name: PP2-STAT3N dissociation
is version of: GO:0043624
product: 049909
reversible: false
kinetic law: 049921

049885
stoichiometry: 1.0
species: metaid_0000163
type: SpeciesReference

metaid_0000141
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: Mrna-SOCS3N
type: Species

metaid_0000233
kinetic law: 050895
product: 050883
reactant: 050871
reactant: 050859
is version of: GO:0005515
fast: false
reversible: true
name: Raf-Phosp1 complex formation
type: Reaction

049584
stoichiometry: 1.0
species: metaid_0000164
type: SpeciesReference

metaid_0000108
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytosol
type: Compartment

048792
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

metaid_0000223
kinetic law: 050413
product: 050401
reactant: 050389
reactant: 050377
is version of: GO:0005515
fast: false
reversible: true
name: SHP2Grb2-SOS complex formation
type: Reaction

metaid_0000118
has only substance units: false
has part: P22272
in compartment: metaid_0000108
boundary condition: false
name: (IL6-gp80-gp130-JAK)ast2-STAT3C
constant: false
type: Species
has part: P42227
has part: P52332
initial amount: NaN
has part: Q6PDI9
has part: P08505
initial concentration: 0.0

048467
stoichiometry: 1.0
species: metaid_0000111
type: SpeciesReference

metaid_0000187
reversible: false
product: 048792
is: http://identifiers.org/ec-code/2.7.10.2
product: 048804
reactant: 048780
kinetic law: 048816
name: IL6-gp80-gp130-JAK -STAT3C dissociation
is: GO:0043624
type: Reaction
is: GO:0004713
fast: false

metaid_0000048
constant: true
value: 0.005
type: Parameter

metaid_0000243
is: GO:0004708
type: Reaction
product: 051364
reactant: 051340
is: http://identifiers.org/ec-code/2.7.12.2
reversible: false
fast: false
name: ERK-MEK-PP complex dissociation
product: 051352
kinetic law: 051376

metaid_0000214
kinetic law: 050041
product: 050029
reactant: 050017
is version of: GO:0006611
fast: false
reversible: false
name: SOCS3 mRNA translocation
type: Reaction

049609
stoichiometry: 1.0
species: metaid_0000133
type: SpeciesReference

metaid_0000204
kinetic law: 049621
product: 049609
reactant: 049597
reactant: 049584
is version of: GO:0005515
fast: false
reversible: false
name: Complex formation
type: Reaction

metaid_0000007
constant: true
value: 0.05
type: Parameter

051496
stoichiometry: 1.0
species: metaid_0000176
type: SpeciesReference

050437
stoichiometry: 1.0
species: metaid_0000143
type: SpeciesReference

metaid_0000128
boundary condition: false
constant: false
has part: P35235
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
has only substance units: false
has part: Q60631
name: SHP2ast-Grb2-SOS
type: Species

metaid_0000173
boundary condition: false
in compartment: metaid_0000108
name: ERK-P-MEK-PP
has part: P63085
constant: false
initial amount: NaN
has part: Q3TMJ8
initial concentration: 0.0
type: Species
has only substance units: false

051508
stoichiometry: 1.0
species: metaid_0000157
type: SpeciesReference

metaid_0000234
kinetic law: 050943
product: 050931
reactant: 050919
reactant: 050907
is version of: GO:0005515
fast: false
reversible: true
name: MEK-Raf complex formation
type: Reaction

metaid_0000109
is version of: P22272
constant: true
boundary condition: true
has only substance units: false
initial concentration: 8.0
initial amount: NaN
in compartment: metaid_0000108
name: gp80
type: Species

051171
stoichiometry: 1.0
species: metaid_0000154
type: SpeciesReference

metaid_0000089
constant: true
value: 0.058
type: Parameter

049212
stoichiometry: 1.0
species: metaid_0000132
type: SpeciesReference

metaid_0000213
kinetic law: 050005
modifier: 049993
product: 049981
is: GO:0006351
fast: false
reversible: false
name: SOCS3N transcription
type: Reaction

048402
stoichiometry: 1.0
species: metaid_0000110
type: SpeciesReference

metaid_0000224
kinetic law: 050461
product: 050449
reactant: 050437
reactant: 050425
is version of: GO:0005515
fast: false
reversible: true
name: Complex formation
type: Reaction

050377
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000099
constant: true
value: 0.033
type: Parameter

049945
stoichiometry: 1.0
species: metaid_0000139
type: SpeciesReference

metaid_0000186
kinetic law: 048767
product: 048755
reactant: 048743
reactant: 048731
is version of: GO:0046983
fast: false
reversible: false
name: IL6-gp80-gp130-JAK -STAT3C complex formation
type: Reaction

metaid_0000172
type: Species
has part: P22272
has part: P42227
in compartment: metaid_0000108
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 0.0
has part: P08505
has part: P35235
has part: Q6PDI9
has part: P52332
has only substance units: false
name: (IL6-gp80-gp130-JAK)ast2-STAT3C-SHP2

metaid_0000119
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: STAT3Cast
type: Species

metaid_0000047
constant: true
value: 2.0E-7
type: Parameter

metaid_0000244
kinetic law: 051424
product: 051412
product: 051400
reactant: 051388
is version of: GO:0043624
fast: false
reversible: true
name: ERK-P-MEK-PP complex dissociation
type: Reaction

metaid_0000203
kinetic law: 049572
product: 049560
product: 049548
reactant: 049536
is version of: GO:0032516
fast: false
reversible: false
name: PP1-STAT3C dimer dissociation
type: Reaction

metaid_0000008
constant: true
value: 0.02
type: Parameter

048828
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

048571
stoichiometry: 2.0
species: metaid_0000111
type: SpeciesReference

051641
stoichiometry: 1.0
species: metaid_0000160
type: SpeciesReference

metaid_0000129
has part: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: PP1-STAT3Cast
type: Species

049428
stoichiometry: 1.0
species: metaid_0000129
type: SpeciesReference

metaid_0000202
kinetic law: 049524
product: 049512
reactant: 049500
is version of: GO:0000060
fast: false
reversible: false
name: STAT3C dimer phosphorylation
type: Reaction

metaid_0000088
constant: true
value: 0.001833
type: Parameter

metaid_0000235
is: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
product: 050979
reactant: 050955
kinetic law: 050991
name: MEK-Raf complex dissociation
type: Reaction
is: GO:0004672
product: 050967

049512
stoichiometry: 1.0
species: metaid_0000135
type: SpeciesReference

metaid_0000221
kinetic law: 050317
product: 050305
reactant: 050293
reactant: 050281
is version of: GO:0005515
fast: false
reversible: true
name: Complex formation
type: Reaction

048585
stoichiometry: 1.0
species: metaid_0000113
type: SpeciesReference

metaid_0000019
constant: true
value: 0.001
type: Parameter

metaid_0000216
kinetic law: 050101
modifier: 050089
product: 050077
is version of: GO:0006412
fast: false
reversible: false
name: SOCS3 translation
type: Reaction

050449
stoichiometry: 1.0
species: metaid_0000144
type: SpeciesReference

049681
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

metaid_0000241
kinetic law: 051280
product: 051267
reactant: 051255
reactant: 051243
is version of: GO:0005515
fast: false
reversible: true
name: MEK-PP-Phosp2 complex formation
type: Reaction

metaid_0000116
is version of: P35235
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000108
name: SHP2
type: Species

metaid_0000185
fast: false
type: Reaction
product: 048707
is version of: GO:0043624
name: IL6-gp80-gp130-JAK dimer-SHP2 dissociation
reactant: 048683
is: http://identifiers.org/ec-code/3.1.3.48
reversible: false
kinetic law: 048719
product: 048695

049597
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000175
boundary condition: false
constant: false
initial amount: NaN
name: Grb2-SOS
in compartment: metaid_0000108
has part: Q60631
type: Species
initial concentration: 0.0
has part: Q62245
has only substance units: false

metaid_0000009
constant: true
value: 0.02
type: Parameter

049080
stoichiometry: 1.0
species: metaid_0000128
type: SpeciesReference

metaid_0000201
kinetic law: 049488
product: 049476
reactant: 049464
reactant: 049452
is version of: GO:0005515
fast: false
reversible: true
name: PP1-STAT3C dimer complex formation
type: Reaction

051099
stoichiometry: 1.0
species: metaid_0000168
type: SpeciesReference

048755
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

metaid_0000087
constant: true
value: 0.011
type: Parameter

049933
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000222
kinetic law: 050365
product: 050353
reactant: 050341
reactant: 050329
is version of: GO:0005515
fast: false
reversible: true
name: Complex formation
type: Reaction

metaid_0000049
constant: true
value: 0.01
type: Parameter

051629
stoichiometry: 1.0
species: metaid_0000176
type: SpeciesReference

metaid_0000215
kinetic law: 050065
reactant: 050053
is version of: GO:0006402
fast: false
reversible: false
name: SOCS3 mRNA degradation
type: Reaction

metaid_0000184
kinetic law: 048671
product: 048659
reactant: 048647
is: GO:0004713
is: http://identifiers.org/ec-code/2.7.10.2
fast: false
reversible: false
name: IL6-gp80-gp130-JAK dimer phosphorylation
type: Reaction

metaid_0000242
kinetic law: 051328
product: 051316
reactant: 051304
reactant: 051292
is version of: GO:0005515
fast: false
reversible: true
name: ERK-MEK-PP complex formation
type: Reaction

metaid_0000117
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1000.0
initial amount: NaN
in compartment: metaid_0000108
name: STAT3C
type: Species

050787
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

metaid_0000174
has part: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: PP1-STAT3Cast-STAT3Cast
type: Species

metaid_0000236
kinetic law: 051039
product: 051027
reactant: 051015
reactant: 051003
is version of: GO:0005515
fast: false
reversible: true
name: MEK-P-Raf complex formation
type: Reaction

050137
stoichiometry: 1.0
species: metaid_0000133
type: SpeciesReference

049296
stoichiometry: 1.0
species: metaid_0000133
type: SpeciesReference

metaid_0000059
constant: true
value: 0.01
type: Parameter

metaid_0000247
reversible: false
product: 051544
reactant: 051532
fast: false
name: ERK-PP-Phosp3 dissociation
kinetic law: 051568
is version of: GO:0043624
product: 051556
type: Reaction
is version of: GO:0032516

048623
stoichiometry: 2.0
species: metaid_0000111
type: SpeciesReference

051003
stoichiometry: 1.0
species: metaid_0000153
type: SpeciesReference

050642
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000197
kinetic law: 049284
product: 049272
reactant: 049260
reactant: 049248
is version of: GO:0005515
fast: false
reversible: true
name: IL6-gp80-gp130-JAK-SOCS2-STAT3C complex formation
type: Reaction

metaid_0000104
constant: true
value: 0.005
type: Parameter

metaid_0000177
has part: P63085
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: ERK-PP-Phosp3
type: Species

metaid_0000208
kinetic law: 049777
product: 049765
reactant: 049753
reactant: 049741
is version of: GO:0005515
fast: false
reversible: true
name: PP2-STAT3N dimer complex formation
type: Reaction

050691
stoichiometry: 1.0
species: metaid_0000175
type: SpeciesReference

049416
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

049500
stoichiometry: 1.0
species: metaid_0000134
type: SpeciesReference

metaid_0000218
kinetic law: 050173
product: 050161
product: 050149
reactant: 050137
is version of: GO:0043624
fast: false
reversible: false
name: Complex dissociation
type: Reaction

048519
stoichiometry: 1.0
species: metaid_0000169
type: SpeciesReference

051316
stoichiometry: 1.0
species: metaid_0000158
type: SpeciesReference

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri

metaid_0000220
kinetic law: 050269
product: 050257
product: 050245
reactant: 050233
is version of: GO:0043624
fast: false
reversible: true
name: Grb2-SOS dissociation
type: Reaction

metaid_0000248
kinetic law: 051616
product: 051604
reactant: 051592
reactant: 051580
is version of: GO:0005515
fast: false
reversible: true
name: ERK-P-Phosp3 formation
type: Reaction

050979
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

050149
stoichiometry: 1.0
species: metaid_0000172
type: SpeciesReference

metaid_0000230
kinetic law: 050751
product: 050739
reactant: 050727
reactant: 050715
is version of: GO:0043623
fast: false
reversible: true
name: Complex formation
type: Reaction

metaid_0000105
constant: true
value: 0.5
type: Parameter

metaid_0000196
kinetic law: 049236
product: 049224
reactant: 049212
is version of: GO:0006611
fast: false
reversible: false
name: STAT3N transport
type: Reaction

metaid_0000176
constant: false
boundary condition: false
has only substance units: false
initial concentration: 16667.0
initial amount: NaN
in compartment: metaid_0000108
name: Phosp3
type: Species

metaid_0000207
kinetic law: 049729
product: 049717
reactant: 049705
is version of: GO:0043624
fast: false
reversible: true
name: STAT3N dimer dissociation
type: Reaction

metaid_0000217
kinetic law: 050125
reactant: 050113
is version of: GO:0030163
fast: false
reversible: false
name: SOCS3 degradation
type: Reaction

049368
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

048743
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

051063
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

050353
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

050630
stoichiometry: 1.0
species: metaid_0000175
type: SpeciesReference

metaid_0000106
constant: true
value: 0.014
type: Parameter

metaid_0000231
kinetic law: 050799
product: 050787
product: 050775
reactant: 050763
is version of: GO:0032516
fast: false
reversible: false
name: Raf-Phosp1 dissociation
type: Reaction

metaid_0000199
kinetic law: 049392
product: 049380
reactant: 049368
is version of: GO:0046983
fast: false
reversible: true
name: STAT3C dimerization
type: Reaction

048780
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

metaid_0000179
kinetic law: 048454
reactant: 048441
is version of: GO:0043624
fast: false
reversible: false
name: IL6-gp80 complex dissociation
type: Reaction

metaid_0000206
kinetic law: 049693
product: 049681
reactant: 049669
is: GO:0004713
is: http://identifiers.org/ec-code/2.7.10.2
fast: false
reversible: true
name: IL6-gp80-gp130-JAK-SHP2 phosphorylation
type: Reaction

051604
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

051580
stoichiometry: 1.0
species: metaid_0000176
type: SpeciesReference

metaid_0000189
kinetic law: 048912
product: 048900
reactant: 048888
reactant: 048876
is version of: GO:0005515
fast: false
reversible: true
name: IL6-gp80-gp130-JAK -SHP2 complex formation
type: Reaction

metaid_0000245
name: ERK-PP formation
product: 051460
is: GO:0004708
is: http://identifiers.org/ec-code/2.7.12.2
type: Reaction
kinetic law: 051472
reversible: false
product: 051448
reactant: 051436
fast: false

049404
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

051653
stoichiometry: 1.0
species: metaid_0000177
type: SpeciesReference

048388
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

051304
stoichiometry: 1.0
species: metaid_0000156
type: SpeciesReference

metaid_0000107
constant: true
value: 0.6
type: Parameter

metaid_0000198
reactant: 049296
type: Reaction
product: 049308
product: 049320
name: IL6-gp80-gp130-JAK-STAT3C-SOCS3-SHP2 dissociation
product: 049344
kinetic law: 049356
reversible: false
is: http://identifiers.org/ec-code/3.1.3.48
is: GO:0043624
fast: false
product: 049332

049272
stoichiometry: 1.0
species: metaid_0000164
type: SpeciesReference

050967
stoichiometry: 1.0
species: metaid_0000153
type: SpeciesReference

metaid_0000232
kinetic law: 050847
product: 050835
product: 050823
reactant: 050811
is version of: GO:0005515
fast: false
reversible: true
name: Raf-Ras-GTP dissociation
type: Reaction

metaid_0000178
kinetic law: 048428
modifier: 048415
product: 048402
is version of: GO:0005515
fast: false
reversible: false
name: IL6-gp80 complex formation
type: Reaction

048731
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

metaid_0000205
kinetic law: 049657
product: 049645
reactant: 049633
is version of: GO:0016311
fast: false
reversible: false
name: SHP2 dephosphorylation
type: Reaction

049957
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

051075
stoichiometry: 1.0
species: metaid_0000151
type: SpeciesReference

050341
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

049741
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

metaid_0000246
fast: false
type: Reaction
kinetic law: 051520
reactant: 051484
is version of: GO:0043624
reversible: false
product: 051496
is version of: GO:0032516
name: ERK-P-Phosp3 complex dissociation
product: 051508

metaid_0000188
kinetic law: 048864
product: 048852
reactant: 048840
reactant: 048828
is version of: GO:0043623
fast: false
reversible: true
name: IL6-gp80-gp130-JAK-STAT3Cast complex formation
type: Reaction

metaid_0000219
kinetic law: 050221
product: 050209
reactant: 050197
reactant: 050185
is version of: GO:0005515
fast: false
reversible: true
name: SHP2-Grb2 complex formation
type: Reaction

W3 CDTF: Fri Aug 31 16:36:58 BST 2007