207801
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

metaid_0000052
has part: Q60778
has part: O88522
has part: O88351
has part: P25799
has part: Q60680
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000040

208771
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

208375
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000042
is version of: P25799
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: metaid_0000040
type: Species

metaid_0000012
constant: true
value: 0.00135
type: Parameter

208303
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

metaid_0000081
kinetic law: 207914
product: 207901
reactant: 207888
is version of: GO:0044257
fast: false
reversible: false
name: IkBalpha degradation
type: Reaction

208090
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

metaid_0000095
kinetic law: 208291
product: 208279
is version of: GO:0006351
fast: false
reversible: false
name: IkBbeta transcription
type: Reaction

metaid_0000053
constant: false
has part: O88522
type: Species
has only substance units: false
initial amount: NaN
has part: Q60680
in compartment: metaid_0000040
has part: O54910
has part: O88351
boundary condition: false
initial concentration: 0.0

metaid_0000117
is version of: GO:0005515
fast: false
product: 208831
reversible: true
kinetic law: 208843
name: IKK-binary IkBalpha NFkB complex formation
reactant: 208819
type: Reaction
reactant: 208807
is version of: GO:0043623

207814
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

207752
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

207716
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000043
has part: Q9Z1E3
has part: P25799
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000040
type: Species

metaid_0000080
fast: false
has part: http://identifiers.org/ec-code/2.7.11.10
is version of: GO:0044257
name: IkBeps degradation
kinetic law: 207875
reversible: false
reactant: 207838
product: 207862
product: 207850
type: Reaction

metaid_0000013
constant: true
value: 5.4
type: Parameter

metaid_0000094
kinetic law: 208267
reactant: 208255
is version of: GO:0006402
fast: false
reversible: false
name: IkBalpha transcript degradation
type: Reaction

metaid_0000003
constant: true
value: 30.0
type: Parameter

209001
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

208387
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

208783
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

metaid_0000040
is: GO:0005737
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

207692
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000054
has part: O88522
has part: O88351
has part: O54910
constant: false
has part: P25799
has part: Q60680
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 0.0
has only substance units: false
in compartment: metaid_0000040

208687
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

metaid_0000083
kinetic law: 207989
product: 207977
reactant: 207964
is version of: GO:0044257
fast: false
reversible: false
name: IkBeps degradation
type: Reaction

metaid_0000014
constant: true
value: 0.0048
type: Parameter

metaid_0000068
kinetic law: 207535
product: 207522
reactant: 207510
reactant: 207498
is version of: GO:0005515
fast: false
reversible: true
name: NFkB-IkBbeta complex formation
type: Reaction

metaid_0000028
constant: true
value: 0.54
type: Parameter

metaid_0000093
kinetic law: 208243
modifier: 208231
product: 208219
is version of: GO:0006351
fast: false
reversible: false
name: IkBalpha inducible transcription
type: Reaction

metaid_0000119
kinetic law: 208879
product: 208867
reactant: 208855
is version of: GO:0006611
fast: false
reversible: false
name: IkBalpha_NFkB translocation
type: Reaction

207595
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

207764
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000055
is version of: P25799
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.001
initial amount: NaN
in compartment: metaid_0000124
type: Species

metaid_0000041
is version of: Q9Z1E3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: metaid_0000040
type: Species

metaid_0000129
kinetic law: 209193
reactant: 209181
fast: false
reversible: false
name: IKK consumption
type: Reaction

207667
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

207862
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000082
kinetic law: 207952
product: 207939
reactant: 207926
is version of: GO:0044257
fast: false
reversible: false
name: IkBbeta degradation
type: Reaction

metaid_0000109
kinetic law: 208651
product: 208639
reactant: 208627
is version of: GO:0000060
fast: false
reversible: true
name: IkBbeta translocation
type: Reaction

metaid_0000015
constant: true
value: 9.25E-5
type: Parameter

metaid_0000029
constant: true
value: 0.105
type: Parameter

metaid_0000092
kinetic law: 208207
product: 208194
is version of: GO:0006351
fast: false
reversible: false
name: IkBalpha transcription
type: Reaction

208543
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

metaid_0000036
constant: true
value: 0.2442
type: Parameter

metaid_0000046
is version of: O54910
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000040
type: Species

metaid_0000016
constant: true
value: 0.99
type: Parameter

208819
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

207437
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000006
constant: true
value: 0.03
type: Parameter

metaid_0000056
is version of: Q9Z1E3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000124
type: Species

metaid_0000132
constant: false
value: 1.0
type: Parameter

metaid_0000026
constant: true
value: 0.36
type: Parameter

208831
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

208904
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

208891
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000108
kinetic law: 208615
reactant: 208603
is version of: GO:0044257
fast: false
reversible: false
name: IkBbeta degradation
type: Reaction

metaid_0000066
kinetic law: 207485
product: 207473
reactant: 207461
reactant: 207449
is version of: GO:0005515
fast: false
reversible: true
name: NFkB-IkBalpha complex formation
type: Reaction

208399
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

metaid_0000099
reversible: true
reactant: 208387
fast: false
product: 208399
kinetic law: 208411
is version of: GO:0005515
reactant: 208375
is version of: GO:0043623
type: Reaction
name: IKK-IkBalpha complex formation

209157
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

207498
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000037
constant: true
value: 0.09
type: Parameter

209181
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000141
constant: false
value: NaN
type: Parameter

metaid_0000047
has part: P25799
has part: O54910
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000040
type: Species

208747
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000017
constant: true
value: 0.0168
type: Parameter

metaid_0000007
constant: true
value: 30.0
type: Parameter

207850
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

207510
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

metaid_0000057
has part: P25799
has part: Q9Z1E3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000124
type: Species

metaid_0000131
constant: false
value: 0.0
type: Parameter

metaid_0000077
is version of: GO:0044257
kinetic law: 207776
type: Reaction
product: 207752
has part: http://identifiers.org/ec-code/2.7.11.10
fast: false
name: IkBbeta degradation
reversible: false
reactant: 207740
product: 207764

metaid_0000027
constant: true
value: 0.105
type: Parameter

207838
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

metaid_0000120
reactant: 208891
name: IKK binary IkBbeta NFkB complex formation
type: Reaction
reversible: true
reactant: 208904
is version of: GO:0043623
is version of: GO:0005515
product: 208916
fast: false
kinetic law: 208928

BIOMD0000000140
reaction: metaid_0000080
reaction: metaid_0000082
reaction: metaid_0000125
species: metaid_0000052
reaction: metaid_0000083
parameter: metaid_0000132
units def: metaid_0000133
reaction: metaid_0000099
reaction: metaid_0000107
species: metaid_0000051
reaction: metaid_0000095
parameter: metaid_0000030
species: metaid_0000055
species: metaid_0000057
parameter: metaid_0000012
rule: metaid_0000137
reaction: metaid_0000078
species: metaid_0000043
time units: metaid_0000134
parameter: metaid_0000038
reaction: metaid_0000072
species: metaid_0000045
parameter: metaid_0000024
notes: This model corresponds to the IkB-NFkB signaling in wild type cells and reproduces the dynamics of the species as depicted in Figure 2 F of the paper. The authors mention that the simulation is carried out in three phases, where the steady state values of the species in one phase are fed to the succeding phase. This model captures the simulation dynamics of two phases and makes use of the event section to introduce the stimulus and thereby transition to the next phase. Accordingly, a few terms have been introduced that make this transition possible, this in no way compromises the original model. Also, the simulation plots are not an exact reproduction of the figures in the paper, they do however match the simulation results that the authors shared with us. Model was successfully tested on MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
rule: metaid_0000142
reaction: metaid_0000088
reaction: metaid_0000084
parameter: metaid_0000025
reaction: metaid_0000115
species: metaid_0000062
parameter: metaid_0000006
reaction: metaid_0000101
area units: metaid_0000005
parameter: metaid_0000037
parameter: metaid_0000011
reaction: metaid_0000127
parameter: metaid_0000007
reaction: metaid_0000102
reaction: metaid_0000075
parameter: metaid_0000032
reaction: metaid_0000128
reaction: metaid_0000090
parameter: metaid_0000135
parameter: metaid_0000034
parameter: metaid_0000019
reaction: metaid_0000114
reaction: metaid_0000096
is: MODEL7158174175
reaction: metaid_0000092
parameter: metaid_0000141
units def: metaid_0000134
curated: true
species: metaid_0000050
species: metaid_0000054
parameter: metaid_0000144
reaction: metaid_0000117
species: metaid_0000056
reaction: metaid_0000119
name: Hoffmann2002_WT_IkBNFkB_Signaling
parameter: metaid_0000031
species: metaid_0000042
parameter: metaid_0000027
reaction: metaid_0000129
reaction: metaid_0000122
parameter: metaid_0000013
parameter: metaid_0000009
reaction: metaid_0000077
species: metaid_0000049
parameter: metaid_0000039
species: metaid_0000059
parameter: metaid_0000014
species: metaid_0000063
species: metaid_0000065
species: metaid_0000047
parameter: metaid_0000026
parameter: metaid_0000020
parameter: metaid_0000016
compartment: metaid_0000040
substance units: metaid_0000133
parameter: metaid_0000021

metaid_0000084
kinetic law: 208027
product: 208014
reactant: 208001
is version of: GO:0000060
fast: false
reversible: true
name: NFkB translocation
type: Reaction

metaid_0000098
kinetic law: 208363
reactant: 208351
is version of: GO:0006402
fast: false
reversible: false
name: IkBeps transcript degradation
type: Reaction

208327
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

metaid_0000107
kinetic law: 208591
modifier: 208579
product: 208567
is version of: GO:0006412
fast: false
reversible: false
name: IkBbeta synthesis
type: Reaction

metaid_0000044
is version of: Q60778
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000040
type: Species

metaid_0000144
constant: false
value: 0.5
type: Parameter

metaid_0000018
constant: true
value: 1.068E-5
type: Parameter

207926
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000058
is version of: Q60778
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000124
type: Species

metaid_0000130
event assignment: 209241
event assignment: 209229
event assignment: 209217
trigger: 209205
notes: The events section is used to set the IKK signal, the system is allowed to equilibrate for 2000 minutes and IKK is increased to 0.1 uM. trigger value is a parameter that is zero until equilibration and then is set to 1, this in turn is used in the rate rule section for "fr_after_trigger". The latter term corresponds to fr in the paper.
use values from trigger time: true
type: Event

metaid_0000024
constant: true
value: 0.018
type: Parameter

208531
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

208807
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

207425
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000004
constant: true
value: 0.03
type: Parameter

metaid_0000078
product: 207814
reactant: 207789
name: NFkB binary IKK IkBeps complex formation
type: Reaction
fast: false
reactant: 207801
kinetic law: 207826
is version of: GO:0043623
is version of: GO:0005515
reversible: true

209145
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

metaid_0000097
kinetic law: 208339
product: 208327
is version of: GO:0006351
fast: false
reversible: false
name: IkBeps transcription
type: Reaction

metaid_0000038
constant: true
value: 0.132
type: Parameter

metaid_0000064
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000124
type: Species

208940
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000019
constant: true
value: 7.62E-6
type: Parameter

metaid_0000045
has part: P25799
has part: Q60778
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000040
type: Species

metaid_0000143
constant: false
value: 0.5
type: Parameter

207522
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

207939
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

207789
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000025
constant: true
value: 0.012
type: Parameter

metaid_0000059
has part: P25799
has part: Q60778
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000124
type: Species

metaid_0000005
constant: true
value: 30.0
type: Parameter

208855
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

207964
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

207571
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

metaid_0000086
reactant: 208052
type: Reaction
kinetic law: 208077
name: NFkB-IkBalpha complex formation
is version of: GO:0043623
reversible: true
fast: false
is version of: GO:0005515
reactant: 208040
product: 208065

207977
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000105
type: Reaction
reactant: 208519
reactant: 208531
product: 208543
fast: false
is version of: GO:0043623
is version of: GO:0005515
reversible: true
kinetic law: 208555
name: IKK-IkBbeta complex formation

metaid_0000039
constant: true
value: 0.0072
type: Parameter

metaid_0000096
kinetic law: 208315
reactant: 208303
is version of: GO:0006402
fast: false
reversible: false
name: IkBbeta transcript degradation
type: Reaction

metaid_0000065
has part: P25799
has part: O54910
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000124
type: Species

208040
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

metaid_0000124
is: GO:0005634
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

metaid_0000072
is version of: GO:0043623
product: 207619
reactant: 207607
name: NFkB-binary IKK IkBalpha complex formation
kinetic law: 207631
reversible: true
type: Reaction
fast: false
reactant: 207595
is version of: GO:0005515

208639
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

208867
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000062
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000124
type: Species

207740
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000023
constant: true
value: 0.00678
type: Parameter

209085
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

207901
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

208168
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

metaid_0000135
constant: false
value: NaN
type: Parameter

metaid_0000033
constant: true
value: 0.624
type: Parameter

metaid_0000123
type: Reaction
reactant: 209001
kinetic law: 209025
is version of: GO:0005515
name: IKK binary IkBeps NFkB complex formation
product: 209013
fast: false
reversible: true
is version of: GO:0043623
reactant: 208988

metaid_0000063
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000124
type: Species

209109
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

208103
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

metaid_0000088
name: NFkB-IkBbeta complex formation
reactant: 208090
is version of: GO:0043623
is version of: GO:0005515
kinetic law: 208129
type: Reaction
product: 208116
fast: false
reactant: 208103
reversible: true

208255
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

209037
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

208116
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

208567
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

metaid_0000022
constant: true
value: 0.2448
type: Parameter

207473
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000136
constant: false
value: NaN
type: Parameter

208495
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

metaid_0000032
constant: true
value: 2.88
type: Parameter

metaid_0000103
kinetic law: 208507
product: 208495
reactant: 208483
is version of: GO:0000060
fast: false
reversible: true
name: IkBalpha translocation
type: Reaction

208155
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

207449
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

208627
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

metaid_0000122
kinetic law: 208964
product: 208952
reactant: 208940
is version of: GO:0006611
fast: false
reversible: false
name: IkBbeta_NFkB translocation
type: Reaction

metaid_0000049
has only substance units: false
has part: O88351
type: Species
initial amount: NaN
has part: O88522
has part: Q9Z1E3
constant: false
has part: P25799
boundary condition: false
has part: Q60680
in compartment: metaid_0000040
initial concentration: 0.0

207547
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000074
product: 207655
reversible: false
fast: false
type: Reaction
kinetic law: 207679
name: IkBalpha degradation
product: 207667
is version of: GO:0044257
has part: http://identifiers.org/ec-code/2.7.11.10
reactant: 207643

metaid_0000060
is version of: O54910
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000124
type: Species

metaid_0000133
unit: 207425
name: micro mole
type: SBMLUnitsDef

208142
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

metaid_0000021
constant: true
value: 0.075
type: Parameter

metaid_0000008
constant: true
value: 0.03
type: Parameter

metaid_0000035
constant: true
value: 0.624
type: Parameter

208459
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

208964
local parameters: 208976
notes: The sum of "flag_for_after_signal" and "fr_after_trigger" insures that the value of the fraction of "IkBbeta_nuc_ NFkB_nuc" capable of nuclear export is equal to one before the signal is introduced and then follows the rate rule for "fr_after_trigger" after the signal is introduced.
type: KineticLaw

209073
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

208711
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000102
kinetic law: 208471
reactant: 208459
is version of: GO:0044257
fast: false
reversible: false
name: IkBalpha degradation
type: Reaction

209121
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

208194
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

209049
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

208916
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000111
is version of: GO:0005515
reactant: 208663
product: 208687
name: IKK-IkBeps complex formation
is version of: GO:0043623
fast: false
kinetic law: 208699
reversible: true
reactant: 208675
type: Reaction

metaid_0000075
is version of: GO:0043623
reactant: 207704
product: 207716
kinetic law: 207728
type: Reaction
reactant: 207692
fast: false
name: NFkB binary IKK IkBbeta complex formation
is version of: GO:0005515
reversible: true

208423
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000009
constant: true
value: 1.224
type: Parameter

metaid_0000020
constant: true
value: 1.35
type: Parameter

metaid_0000134
unit: 207437
name: minutes
type: SBMLUnitsDef

metaid_0000048
initial amount: NaN
constant: false
has only substance units: false
has part: Q9Z1E3
has part: Q60680
in compartment: metaid_0000040
type: Species
has part: O88522
boundary condition: false
has part: O88351
initial concentration: 0.0

metaid_0000034
constant: true
value: 4.2
type: Parameter

208483
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

207461
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000101
kinetic law: 208447
modifier: 208435
product: 208423
is version of: GO:0006412
fast: false
reversible: false
name: IkBalpha synthesis
type: Reaction

metaid_0000139
constant: false
value: NaN
type: Parameter

208976
value: 0.0069
type: LocalParameter

metaid_0000114
kinetic law: 208759
reactant: 208747
is version of: GO:0044257
fast: false
reversible: false
name: IkBeps degradation
type: Reaction

208014
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

207559
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

207655
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

209205
persistant: true
initial value: true
type: Trigger

metaid_0000128
kinetic law: 209169
product: 209157
reactant: 209145
is version of: GO:0044257
has part: http://identifiers.org/ec-code/2.7.11.10
fast: false
reversible: false
name: IkBeps degradation
type: Reaction

metaid_0000113
kinetic law: 208735
modifier: 208723
product: 208711
is version of: GO:0006412
fast: false
reversible: false
name: IkBeps synthesis
type: Reaction

207643
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

207607
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

208675
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000127
kinetic law: 209133
product: 209121
reactant: 209109
is version of: GO:0044257
has part: http://identifiers.org/ec-code/2.7.11.10
fast: false
reversible: false
name: IkBbeta degradation
type: Reaction

209013
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

208351
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

208279
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

208988
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000070
kinetic law: 207583
product: 207571
reactant: 207559
reactant: 207547
is version of: GO:0005515
fast: false
reversible: true
name: NFkB-IkBeps complex formation
type: Reaction

metaid_0000090
reversible: true
type: Reaction
name: NFkB-IkBeps complex formation
reactant: 208155
fast: false
reactant: 208142
product: 208168
is version of: GO:0043623
is version of: GO:0005515
kinetic law: 208181

metaid_0000011
constant: true
value: 0.66
type: Parameter

metaid_0000126
kinetic law: 209097
product: 209085
reactant: 209073
is version of: GO:0044257
has part: http://identifiers.org/ec-code/2.7.11.10
fast: false
reversible: false
name: IkBalpha degradation
type: Reaction

metaid_0000050
type: Species
has only substance units: false
boundary condition: false
has part: O88351
initial concentration: 0.0
constant: false
initial amount: NaN
has part: O88522
has part: Q60680
in compartment: metaid_0000040

207704
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

metaid_0000031
constant: true
value: 0.828
type: Parameter

208603
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

208052
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

208519
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

207619
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

208952
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

208663
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

208001
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

208219
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

metaid_0000125
kinetic law: 209061
product: 209049
reactant: 209037
is version of: GO:0006611
fast: false
reversible: false
name: IkBeps_NFkB translocation
type: Reaction

metaid_0000010
constant: true
value: 0.45
type: Parameter

metaid_0000051
is version of: O88522
constant: false
initial amount: NaN
boundary condition: false
is version of: Q60778
in compartment: metaid_0000040
initial concentration: 0.0
is version of: Q60680
is version of: O88351
type: Species
has only substance units: false

207888
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000030
constant: true
value: 11.1
type: Parameter

208065
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

metaid_0000115
kinetic law: 208795
product: 208783
reactant: 208771
is version of: GO:0000060
fast: false
reversible: true
name: IkBeps translocation
type: Reaction

W3 CDTF: Wed May 16 14:37:19 BST 2007

W3 CDTF: Thu Jul 05 15:50:23 BST 2012

orgname: California Institute of Technology

n:
  given: Harish
  family: Dharuri