840213
value: 1000000.0
type: LocalParameter

712502
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species: 000008
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000002
is: GO:0005623
constant: true
size: 1.0
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712394
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840217
value: 200.0
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stoichiometry: 1.0
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712369
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840227
value: 180.0
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000016
kinetic law: 712634
product: 712622
reactant: 712610
is version of: GO:0008054
fast: false
reversible: false
name: default degradation of cyclin
type: Reaction

712550
stoichiometry: 1.0
species: 000007
type: SpeciesReference

000012
kinetic law: 712478
product: 712466
reactant: 712454
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: cdc2k dephosphorylation
type: Reaction

000006
constant: false
type: Species
has part: IPR006670
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in compartment: 000002
name: p-cyclin_cdc2
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initial amount: 0.0
boundary condition: false
initial concentration: NaN

712646
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712574
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metaid_0000020
is version of: IPR006670
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initial concentration: NaN
initial amount: NaN
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name: total_cyclin
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712694
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712538
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712622
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species: 000003
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000017
kinetic law: 712670
product: 712658
reactant: 712646
is version of: GO:0008054
fast: false
reversible: false
name: cdc2 kinase triggered degration of cyclin
type: Reaction

840221
value: 0.015
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000013
kinetic law: 712526
reversible: false
type: Reaction
has version: REACT 6216
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name: cyclin cdc2k-p association
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boundary condition: false
initial concentration: NaN
name: p-cyclin_cdc2-p
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initial amount: 0.25

000014
has version: REACT 3178
fast: false
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has version: REACT 6327
is version of: http://identifiers.org/ec-code/2.7.10.2
reversible: false
reactant: 712538
type: Reaction
kinetic law: 712562
product: 712550
name: deactivation of cdc2 kinase
is version of: GO:0006468

712490
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species: 000005
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840215
value: 1000.0
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712454
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species: 000005
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name: cdc2k
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BIOMD0000000005
species: metaid_0000020
reaction: 000017
rule: metaid_0000023
volume units: volume
created:
  W3 CDTF: Tue Feb 08 18:28:27 GMT 2005
compartment: 000002
time units: time
reaction: 000013
reaction: 000010
reaction: 000014
modified:
  W3 CDTF: Thu May 16 15:40:43 BST 2013
species: 000004
is described by: http://identifiers.org/pubmed/1831270
species: 000005
is: MODEL6614644188
curated: true
is version of: sce04111
reaction: 000018
rule: metaid_0000021
species: 000008
species: 000009
occurs in: http://identifiers.org/taxonomy/33154
creator:
  ORG:
    orgname: NASA Jet Propulsion Laboratory
  n:
    given: Bruce
    family: Shapiro
name: Tyson1991 - Cell Cycle 6 var
species: metaid_0000022
length unit: length
type: SBMLModel
reaction: 000011
reaction: 000015
reaction: 000016
species: 000003
has version: REACT 152
notes: Tyson1991 - Cell Cycle 6 var Mathematical model of the interactions of cdc2 and cyclin. This model is described in the article: Modeling the cell division cycle: cdc2 and cyclin interactions. Tyson JJ. Proc. Natl. Acad. Sci. U.S.A. 1991; 88(16); 7328-32 Abstract: The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells. This model is hosted on BioModels Database and identified by: BIOMD0000000005 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
area units: area
reaction: 000012
is version of: GO:0000278
species: 000006
species: 000007
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
substance units: substance

712610
stoichiometry: 1.0
species: 000008
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712418
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species: 000004
type: SpeciesReference

000018
has version: REACT 6257
product: 712694
has version: REACT 6294
modifier: 712706
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.16
is version of: GO:0006470
reactant: 712682
kinetic law: 712718
fast: false
name: activation of cdc2 kinase
has version: REACT 6175
reversible: false
is version of: GO:0045737

840219
value: 0.0
type: LocalParameter

000008
is version of: IPR006670
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 000002
name: cyclin
type: Species

712514
stoichiometry: 1.0
species: 000007
type: SpeciesReference

000010
has version: REACT 6308
kinetic law: 712406
is version of: GO:0000079
product: 712394
reversible: false
name: cyclin_cdc2k dissociation
reactant: 712369
product: 712382
type: Reaction
fast: false

840225
value: 0.6
type: LocalParameter

712586
stoichiometry: 1.0
species: 000008
type: SpeciesReference

712682
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000015
kinetic law: 712598
product: 712586
reactant: 712574
is version of: GO:0006412
fast: false
reversible: false
name: cyclin biosynthesis
type: Reaction

metaid_0000022
is version of: P04551
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: total_cdc2
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712658
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species: 000003
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000005
is version of: P04551
constant: false
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initial concentration: NaN
initial amount: 0.75
in compartment: 000002
name: cdc2k-P
type: Species

712382
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840223
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initial concentration: NaN
initial amount: 0.0
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name: p-cyclin
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000011
kinetic law: 712442
product: 712430
reactant: 712418
is version of: GO:0006468
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
name: cdc2k phosphorylation
type: Reaction