348904
stoichiometry: 1.0
species: 986182
type: SpeciesReference

metaid_0000046
constant: true
value: 0.54
type: Parameter

348844
stoichiometry: 1.0
species: 986142
type: SpeciesReference

349097
stoichiometry: 1.0
species: 986162
type: SpeciesReference

metaid_0000052
constant: true
value: 1.5E8
type: Parameter

348772
stoichiometry: 1.0
species: 986222
type: SpeciesReference

metaid_0000066
constant: true
value: 0.05
type: Parameter

349375
notes: kf_14 * I - kr_14 * D
type: KineticLaw

348976
stoichiometry: 1.0
species: 986242
type: SpeciesReference

986683
kinetic law: 349375
product: 349363
reactant: 349351
notes: unlig interm <=> unlig desen
fast: false
reversible: true
name: React14
type: Reaction

349060
stoichiometry: 1.0
species: 986382
type: SpeciesReference

metaid_0000047
constant: true
value: 10800.0
type: Parameter

986663
kinetic law: 349339
reactant: 349303
fast: false
type: Reaction
notes: second ligand on desensitised
reversible: true
reactant: 349315
is: GO:0042166
name: React13
product: 349327

349423
stoichiometry: 1.0
species: 986302
type: SpeciesReference

metaid_0000067
constant: true
value: 0.0012
type: Parameter

349194
stoichiometry: 1.0
species: 986162
type: SpeciesReference

349207
notes: kf_10 * AL - kr_10 * IL
type: KineticLaw

metaid_0000053
constant: true
value: 8.0
type: Parameter

349231
stoichiometry: 1.0
species: 986302
type: SpeciesReference

349036
notes: kf_6 * BL - kr_6 * AL
type: KineticLaw

348916
notes: kf_3 * A * L - kr_3 * AL
type: KineticLaw

348856
stoichiometry: 1.0
species: 986362
type: SpeciesReference

metaid_0000048
constant: true
value: 130.0
type: Parameter

metaid_0000060
constant: true
value: 3.0E8
type: Parameter

986602
kinetic law: 349207
product: 349194
reactant: 349182
notes: monolig act <=> monolig interm
is: GO:0004889
fast: false
reversible: true
name: React10
type: Reaction

metaid_0000058
constant: true
value: 20.0
type: Parameter

metaid_0000050
constant: true
value: 3.0E8
type: Parameter

metaid_0000040
constant: true
value: 30000.0
type: Parameter

348988
stoichiometry: 1.0
species: 986202
type: SpeciesReference

metaid_0000068
constant: true
value: 0.05
type: Parameter

349363
stoichiometry: 1.0
species: 986282
type: SpeciesReference

986402
reactant: 348746
kinetic law: 348784
fast: false
name: React0
reversible: true
product: 348772
reactant: 348760
notes: first ligand on basal
is: GO:0042166
type: Reaction

349339
notes: kf_13 * DL * L - kr_13 * DLL
type: KineticLaw

986443
kinetic law: 348868
product: 348856
reactant: 348844
notes: opening of biliganded
is: GO:0004889
fast: false
reversible: true
name: React2
type: Reaction

348784
notes: kf_0 * B * L - kr_0 * BL
type: KineticLaw

metaid_0000061
constant: true
value: 4.0
type: Parameter

349435
stoichiometry: 1.0
species: 986262
type: SpeciesReference

metaid_0000049
constant: true
value: 2740.0
type: Parameter

986282
notes: fully desensitised state
type: Species
constant: false
is version of: IPR002394
is version of: GO:0005892
boundary condition: false
initial amount: 0.0
has only substance units: false
initial concentration: NaN
in compartment: 986127
name: Desensitised

348928
stoichiometry: 1.0
species: 986182
type: SpeciesReference

metaid_0000059
constant: true
value: 0.81
type: Parameter

986485
fast: false
reactant: 348928
name: React4
product: 348952
kinetic law: 348964
reversible: true
notes: second ligand on active
type: Reaction
is: GO:0042166
reactant: 348940

348940
stoichiometry: 1.0
species: 986382
type: SpeciesReference

metaid_0000051
constant: true
value: 4.0
type: Parameter

349048
stoichiometry: 1.0
species: 986342
type: SpeciesReference

349219
stoichiometry: 1.0
species: 986362
type: SpeciesReference

349303
stoichiometry: 1.0
species: 986322
type: SpeciesReference

metaid_0000069
constant: true
value: 0.0012
type: Parameter

metaid_0000041
constant: true
value: 700.0
type: Parameter

349243
notes: kf_11 * ALL - kr_11 * ILL
type: KineticLaw

349182
stoichiometry: 1.0
species: 986182
type: SpeciesReference

349399
stoichiometry: 1.0
species: 986322
type: SpeciesReference

metaid_0000042
constant: true
value: 3.0E8
type: Parameter

986702
kinetic law: 349411
product: 349399
reactant: 349387
notes: monolig interm <=> monolig desen
fast: false
reversible: true
name: React15
type: Reaction

349327
stoichiometry: 1.0
species: 986262
type: SpeciesReference

349170
notes: kf_9 * A - kr_9 * I
type: KineticLaw

349158
stoichiometry: 1.0
species: 986342
type: SpeciesReference

348796
stoichiometry: 1.0
species: 986222
type: SpeciesReference

986142
initial concentration: NaN
is version of: IPR002394
in compartment: 986127
name: BasalACh2
has only substance units: false
constant: false
initial amount: 0.0
boundary condition: false
notes: biliganded basal state
type: Species
is version of: GO:0005892

348892
stoichiometry: 1.0
species: 986382
type: SpeciesReference

metaid_0000062
constant: true
value: 1.5E8
type: Parameter

348952
stoichiometry: 1.0
species: 986362
type: SpeciesReference

986583
kinetic law: 349170
product: 349158
reactant: 349146
notes: unlig act <=> unlig interm
is: GO:0004889
fast: false
reversible: true
name: React9
type: Reaction

metaid_0000056
constant: true
value: 19.85
type: Parameter

348820
stoichiometry: 1.0
species: 986142
type: SpeciesReference

986162
boundary condition: false
name: IntermediateACh
type: Species
in compartment: 986127
is version of: GO:0005892
is version of: IPR002394
initial concentration: NaN
constant: false
has only substance units: false
notes: monoliganded intermediate
initial amount: 0.0

348746
stoichiometry: 1.0
species: 986242
type: SpeciesReference

349000
notes: kf_5 * B - kr_5 * A
type: KineticLaw

metaid_0000039
constant: true
value: 16000.0
type: Parameter

986522
kinetic law: 349036
product: 349024
reactant: 349012
notes: opening of monoliganded
is: GO:0004889
fast: false
reversible: true
name: React6
type: Reaction

metaid_0000043
constant: true
value: 8.64
type: Parameter

metaid_0000057
constant: true
value: 1.74
type: Parameter

349012
stoichiometry: 1.0
species: 986222
type: SpeciesReference

349255
stoichiometry: 1.0
species: 986282
type: SpeciesReference

349085
notes: kf_7 * I * L - kr_7 * IL
type: KineticLaw

348808
stoichiometry: 1.0
species: 986382
type: SpeciesReference

BIOMD0000000002
reaction: 986503
parameter: metaid_0000041
parameter: metaid_0000039
reaction: 986722
parameter: metaid_0000037
reaction: 986462
parameter: metaid_0000053
reaction: 986423
parameter: metaid_0000044
created:
  W3 CDTF: Wed Feb 02 14:41:42 GMT 2005
parameter: metaid_0000050
parameter: metaid_0000065
reaction: 986643
parameter: metaid_0000056
area units: area
name: Edelstein1996 - EPSP ACh species
parameter: metaid_0000062
parameter: metaid_0000068
substance units: substance
reaction: 986542
length unit: length
parameter: metaid_0000047
reaction: 986563
species: 986142
parameter: metaid_0000059
species: 986302
species: 986242
volume units: volume
reaction: 986522
parameter: metaid_0000060
reaction: 986702
species: 986262
species: 986222
parameter: metaid_0000045
reaction: 986623
curated: true
parameter: metaid_0000051
parameter: metaid_0000042
parameter: metaid_0000057
parameter: metaid_0000048
time units: time
species: 986182
parameter: metaid_0000063
parameter: metaid_0000054
parameter: metaid_0000069
is described by: http://identifiers.org/pubmed/8983160
species: 986202
parameter: metaid_0000066
reaction: 986602
species: 986162
species: 986362
reaction: 986683
parameter: metaid_0000040
parameter: metaid_0000038
occurs in: http://identifiers.org/taxonomy/7787
parameter: metaid_0000036
type: SBMLModel
parameter: metaid_0000061
parameter: metaid_0000052
parameter: metaid_0000064
species: 986342
compartment: 986127
is version of: GO:0007274
reaction: 986485
species: 986382
is: MODEL6614086398
parameter: metaid_0000043
reaction: 986583
is version of: GO:0007166
parameter: metaid_0000049
parameter: metaid_0000055
parameter: metaid_0000046
species: 986322
notes: Edelstein1996 - EPSP ACh species Model of a nicotinic Excitatory Post-Synaptic Potential in a Torpedo electric organ. Acetylcholine is represented explicitely as a molecular species. This model has initially been encoded using StochSim. This model is described in the article: A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions. Edelstein SJ, Schaad O, Henry E, Bertrand D, Changeux JP. Biol. Cybern. 1996 Nov; 75(5):361-79 Abstract: Nicotinic acetylcholine receptors are transmembrane oligomeric proteins that mediate interconversions between open and closed channel states under the control of neurotransmitters. Fast in vitro chemical kinetics and in vivo electrophysiological recordings are consistent with the following multi-step scheme. Upon binding of agonists, receptor molecules in the closed but activatable resting state (the Basal state, B) undergo rapid transitions to states of higher affinities with either open channels (the Active state, A) or closed channels (the initial Inactivatable and fully Desensitized states, I and D). In order to represent the functional properties of such receptors, we have developed a kinetic model that links conformational interconversion rates to agonist binding and extends the general principles of the Monod-Wyman-Changeux model of allosteric transitions. The crucial assumption is that the linkage is controlled by the position of the interconversion transition states on a hypothetical linear reaction coordinate. Application of the model to the peripheral nicotine acetylcholine receptor (nAChR) accounts for the main properties of ligand-gating, including single-channel events, and several new relationships are predicted. Kinetic simulations reveal errors inherent in using the dose-response analysis, but justify its application under defined conditions. The model predicts that (in order to overcome the intrinsic stability of the B state and to produce the appropriate cooperativity) chann…
parameter: metaid_0000067
parameter: metaid_0000058
reaction: 986443
reaction: 986402
reaction: 986663
species: 986282

986503
kinetic law: 349000
product: 348988
reactant: 348976
notes: opening of unliganded
is: GO:0004889
fast: false
reversible: true
name: React5
type: Reaction

986423
reversible: true
notes: second ligand on basal
fast: false
kinetic law: 348832
reactant: 348808
is: GO:0042166
product: 348820
name: React1
type: Reaction
reactant: 348796

986262
has only substance units: false
boundary condition: false
name: DesensitisedACh2
initial concentration: NaN
type: Species
constant: false
in compartment: 986127
notes: biliganded desensitised state
is version of: GO:0005892
initial amount: 0.0

986182
constant: false
is version of: IPR002394
boundary condition: false
initial concentration: NaN
in compartment: 986127
notes: monoliganded active state
name: ActiveACh
is version of: GO:0005892
type: Species
has only substance units: false
initial amount: 0.0

metaid_0000063
constant: true
value: 8.0
type: Parameter

349109
stoichiometry: 1.0
species: 986382
type: SpeciesReference

metaid_0000038
constant: true
value: 1.5E8
type: Parameter

986722
kinetic law: 349447
product: 349435
reactant: 349423
notes: bilig interm <=> bilig desen
fast: false
reversible: true
name: React16
type: Reaction

349315
stoichiometry: 1.0
species: 986382
type: SpeciesReference

349072
stoichiometry: 1.0
species: 986162
type: SpeciesReference

986127
is: GO:0031594
constant: true
size: 1.0E-16
spatial dimensions: 3.0
name: compartment1
type: Compartment

metaid_0000044
constant: true
value: 1.5E8
type: Parameter

metaid_0000054
constant: true
value: 19.7
type: Parameter

986623
kinetic law: 349243
product: 349231
reactant: 349219
notes: bilig act <=> bilig interm
is: GO:0004889
fast: false
reversible: true
name: React11
type: Reaction

349387
stoichiometry: 1.0
species: 986162
type: SpeciesReference

349146
stoichiometry: 1.0
species: 986202
type: SpeciesReference

348964
notes: kf_4 * AL * L - kr_4 * ALL
type: KineticLaw

348880
stoichiometry: 1.0
species: 986202
type: SpeciesReference

986242
notes: unliganded basal state
is version of: GO:0005892
initial amount: 1.0E-22
name: Basal
type: Species
boundary condition: false
has only substance units: false
is version of: IPR002394
constant: false
initial concentration: NaN
in compartment: 986127

metaid_0000064
constant: true
value: 0.05
type: Parameter

348832
notes: kf_1 * BL * L - kr_1 * BLL
type: KineticLaw

349291
notes: kf_12 * D * L - kr_12 * DL
type: KineticLaw

349279
stoichiometry: 1.0
species: 986322
type: SpeciesReference

349447
notes: kf_16 * ILL - kr_16 * DLL
type: KineticLaw

986362
initial amount: 0.0
notes: biliganted active state
has only substance units: false
is version of: IPR002394
initial concentration: NaN
is version of: GO:0005892
boundary condition: false
constant: false
name: ActiveACh2
in compartment: 986127
type: Species

349121
stoichiometry: 1.0
species: 986302
type: SpeciesReference

metaid_0000037
constant: true
value: 8000.0
type: Parameter

349351
stoichiometry: 1.0
species: 986342
type: SpeciesReference

986542
type: Reaction
notes: first ligand on intermediate
product: 349072
kinetic law: 349085
reactant: 349060
reactant: 349048
is: GO:0042166
reversible: true
fast: false
name: React7

986462
product: 348904
notes: first ligand on active
reactant: 348892
is: GO:0042166
type: Reaction
fast: false
reversible: true
kinetic law: 348916
reactant: 348880
name: React3

986643
name: React12
is: GO:0042166
type: Reaction
reactant: 349255
fast: false
product: 349279
reactant: 349267
notes: first ligand on desensitised
reversible: true
kinetic law: 349291

metaid_0000045
constant: true
value: 17.28
type: Parameter

986222
is version of: GO:0005892
initial concentration: NaN
is version of: IPR002394
in compartment: 986127
initial amount: 0.0
type: Species
has only substance units: false
name: BasalACh
notes: monoliganded basal state
boundary condition: false
constant: false

986563
reversible: true
fast: false
reactant: 349109
product: 349121
type: Reaction
kinetic law: 349134
is: GO:0042166
notes: second ligand on intermediate
reactant: 349097
name: React8

348760
stoichiometry: 1.0
species: 986382
type: SpeciesReference

metaid_0000055
constant: true
value: 3.74
type: Parameter

986302
initial concentration: NaN
is version of: GO:0005892
constant: false
in compartment: 986127
name: IntermediateACh2
is version of: IPR002394
notes: biliganded intermediate
initial amount: 0.0
type: Species
has only substance units: false
boundary condition: false

metaid_0000065
constant: true
value: 0.0012
type: Parameter

986322
is version of: IPR002394
notes: monoliganded desensitised state
initial concentration: NaN
boundary condition: false
has only substance units: false
in compartment: 986127
is version of: GO:0005892
initial amount: 0.0
type: Species
name: DesensitisedACh
constant: false

349024
stoichiometry: 1.0
species: 986182
type: SpeciesReference

349267
stoichiometry: 1.0
species: 986382
type: SpeciesReference

986342
boundary condition: false
is version of: IPR002394
type: Species
in compartment: 986127
is version of: GO:0005892
has only substance units: false
notes: unliganted intermediate
initial amount: 0.0
name: Intermediate
initial concentration: NaN
constant: false

349411
notes: kf_15 * IL - kr_15 * DL
type: KineticLaw

349134
notes: kf_8 * IL * L - kr_8 * ILL
type: KineticLaw

986202
name: Active
notes: unkiganded active state
type: Species
is version of: GO:0005892
boundary condition: false
initial amount: 0.0
in compartment: 986127
constant: false
initial concentration: NaN
has only substance units: false

metaid_0000036
constant: true
value: 3.0E8
type: Parameter

348868
notes: kf_2 * BLL - kr_2 * ALL
type: KineticLaw

986382
is: C01996
initial concentration: NaN
is: CHEBI:15355
in compartment: 986127
boundary condition: false
constant: false
notes: ligand
has only substance units: false
name: ACh
initial amount: 1.0E-21
type: Species

W3 CDTF: Tue Dec 11 15:25:56 GMT 2012

orgname: EMBL-EBI

n:
  given: Nicolas
  family: Le Novère