Gch1 DOWN in 'whey diet' vs 'casein control diet'
Gcg DOWN in 'soy diet' vs 'casein control diet'
Cyp4f4 DOWN in 'whey diet' vs 'casein control diet'
Sdc1 DOWN in 'whey diet' vs 'casein control diet'
Thrsp DOWN in 'soy diet' vs 'casein control diet'
Ddah1 UP in 'whey diet' vs 'casein control diet'
Rn50_7_1164.1 DOWN in 'soy diet' vs 'casein control diet'
Cd3g UP in 'soy diet' vs 'casein control diet'
Klf4 DOWN in 'whey diet' vs 'casein control diet'
Gstm1 DOWN in 'whey diet' vs 'casein control diet'
Dbi DOWN in 'whey diet' vs 'casein control diet'
Tspan8 DOWN in 'whey diet' vs 'casein control diet'
Crabp1 UP in 'whey diet' vs 'casein control diet'
Muc13 DOWN in 'whey diet' vs 'casein control diet'
Wfdc6a DOWN in 'soy diet' vs 'casein control diet'
Ptgds DOWN in 'whey diet' vs 'casein control diet'
Reg1a UP in 'soy diet' vs 'casein control diet'
Postn UP in 'soy diet' vs 'casein control diet'
Ezr DOWN in 'whey diet' vs 'casein control diet'
Akr1c13 DOWN in 'whey diet' vs 'casein control diet'
AABR06023961.1 DOWN in 'whey diet' vs 'casein control diet'
Fez1 UP in 'whey diet' vs 'casein control diet'
Hspa5 DOWN in 'whey diet' vs 'casein control diet'
Myo1a DOWN in 'whey diet' vs 'casein control diet'
Ap1s3 DOWN in 'soy diet' vs 'casein control diet'
Hmox1 UP in 'soy diet' vs 'casein control diet'
Si UP in 'soy diet' vs 'casein control diet'
Serpina1 UP in 'whey diet' vs 'casein control diet'
Slc9a2 DOWN in 'whey diet' vs 'casein control diet'
Syn2 UP in 'whey diet' vs 'casein control diet'
LOC688090 UP in 'soy diet' vs 'casein control diet'
Cfd UP in 'whey diet' vs 'casein control diet'
Cldn3 DOWN in 'soy diet' vs 'casein control diet'
Ocln DOWN in 'whey diet' vs 'casein control diet'
Epcam DOWN in 'whey diet' vs 'casein control diet'
Id1 DOWN in 'soy diet' vs 'casein control diet'
Klf4 DOWN in 'soy diet' vs 'casein control diet'
Gucy2c DOWN in 'whey diet' vs 'casein control diet'
Kcnk1 DOWN in 'soy diet' vs 'casein control diet'
Car4 DOWN in 'soy diet' vs 'casein control diet'
Ppap2c DOWN in 'whey diet' vs 'casein control diet'
Ly6al DOWN in 'whey diet' vs 'casein control diet'
Krt18 DOWN in 'whey diet' vs 'casein control diet'
Aqp3 DOWN in 'soy diet' vs 'casein control diet'
Lpl UP in 'whey diet' vs 'casein control diet'
Mapt UP in 'whey diet' vs 'casein control diet'
Guca2a DOWN in 'whey diet' vs 'casein control diet'
Ehhadh DOWN in 'whey diet' vs 'casein control diet'
Cth DOWN in 'soy diet' vs 'casein control diet'
Gne DOWN in 'whey diet' vs 'casein control diet'
Prickle2 UP in 'whey diet' vs 'casein control diet'
Atp12a DOWN in 'soy diet' vs 'casein control diet'
Col1a1 UP in 'soy diet' vs 'casein control diet'
Igkc UP in 'soy diet' vs 'casein control diet'
Gsta3 DOWN in 'whey diet' vs 'casein control diet'
Arg2 DOWN in 'whey diet' vs 'casein control diet'
LOC100912469 DOWN in 'whey diet' vs 'casein control diet'
Man2b1 DOWN in 'soy diet' vs 'casein control diet'
Pebp1 DOWN in 'whey diet' vs 'casein control diet'
Krt19 DOWN in 'whey diet' vs 'casein control diet'
Mmp13 UP in 'soy diet' vs 'casein control diet'
Cldn7 DOWN in 'whey diet' vs 'casein control diet'
Acsl5 DOWN in 'whey diet' vs 'casein control diet'
Pebp1 DOWN in 'soy diet' vs 'casein control diet'
Lgals1 UP in 'whey diet' vs 'casein control diet'
Rsad2 DOWN in 'soy diet' vs 'casein control diet'
Chgb DOWN in 'whey diet' vs 'casein control diet'
Arg2 DOWN in 'soy diet' vs 'casein control diet'
Gstm1 DOWN in 'soy diet' vs 'casein control diet'
Man2b1 DOWN in 'whey diet' vs 'casein control diet'
Ctss DOWN in 'whey diet' vs 'casein control diet'
Pla2g2a DOWN in 'whey diet' vs 'casein control diet'
LOC688459 DOWN in 'whey diet' vs 'casein control diet'
Rbp2 UP in 'soy diet' vs 'casein control diet'
Ckmt1b DOWN in 'whey diet' vs 'casein control diet'
Fabp5 UP in 'soy diet' vs 'casein control diet'
Emp1 DOWN in 'soy diet' vs 'casein control diet'
RGD1305347 DOWN in 'whey diet' vs 'casein control diet'
Gfra2 UP in 'whey diet' vs 'casein control diet'
LOC100909901 DOWN in 'whey diet' vs 'casein control diet'
Ldb3 UP in 'whey diet' vs 'casein control diet'
Cyp4f1 DOWN in 'whey diet' vs 'casein control diet'
Papss2 UP in 'soy diet' vs 'casein control diet'
Fut1 DOWN in 'whey diet' vs 'casein control diet'
Slc11a2 UP in 'soy diet' vs 'casein control diet'
Slc25a10 DOWN in 'whey diet' vs 'casein control diet'
Hook1 DOWN in 'whey diet' vs 'casein control diet'
Cdh17 DOWN in 'whey diet' vs 'casein control diet'
Aqp3 DOWN in 'whey diet' vs 'casein control diet'
Il1a UP in 'soy diet' vs 'casein control diet'
Prap1 UP in 'soy diet' vs 'casein control diet'
Cd52 DOWN in 'whey diet' vs 'casein control diet'
Ampd3 DOWN in 'whey diet' vs 'casein control diet'
Cyp51 DOWN in 'whey diet' vs 'casein control diet'
Pdlim3 UP in 'whey diet' vs 'casein control diet'
Sgk1 DOWN in 'soy diet' vs 'casein control diet'
Hsd11b2 DOWN in 'soy diet' vs 'casein control diet'
Ptn UP in 'whey diet' vs 'casein control diet'
Adam7 DOWN in 'whey diet' vs 'casein control diet'
Bcl2l15 DOWN in 'whey diet' vs 'casein control diet'
Scg3 UP in 'whey diet' vs 'casein control diet'
Scg2 UP in 'whey diet' vs 'casein control diet'
Prdx6 DOWN in 'whey diet' vs 'casein control diet'
Analysis of 'whey diet' vs 'casein control diet'
Fabp1 DOWN in 'soy diet' vs 'casein control diet'
Ptpn3 DOWN in 'whey diet' vs 'casein control diet'
Prph UP in 'whey diet' vs 'casein control diet'
Mep1b DOWN in 'whey diet' vs 'casein control diet'
Chgb DOWN in 'soy diet' vs 'casein control diet'
Slc22a5 DOWN in 'soy diet' vs 'casein control diet'
Cx3cl1 DOWN in 'whey diet' vs 'casein control diet'
Ina UP in 'whey diet' vs 'casein control diet'
Pgap2 DOWN in 'soy diet' vs 'casein control diet'
Slc12a2 DOWN in 'whey diet' vs 'casein control diet'
Muc2 DOWN in 'whey diet' vs 'casein control diet'
Dpep1 DOWN in 'whey diet' vs 'casein control diet'
Resp18 UP in 'whey diet' vs 'casein control diet'
B3galt5 DOWN in 'whey diet' vs 'casein control diet'
Ctsk UP in 'soy diet' vs 'casein control diet'
Ass1 UP in 'whey diet' vs 'casein control diet'
Prkcd DOWN in 'whey diet' vs 'casein control diet'
Semg1 UP in 'soy diet' vs 'casein control diet'
Prss8 DOWN in 'whey diet' vs 'casein control diet'
Serpinb5 DOWN in 'whey diet' vs 'casein control diet'
Hk2 DOWN in 'whey diet' vs 'casein control diet'
Emb DOWN in 'whey diet' vs 'casein control diet'
Clrn3 DOWN in 'soy diet' vs 'casein control diet'
Reg3g UP in 'soy diet' vs 'casein control diet'
Apoe UP in 'soy diet' vs 'casein control diet'
Tvp23b DOWN in 'whey diet' vs 'casein control diet'
Thrsp DOWN in 'whey diet' vs 'casein control diet'
Agtr1a UP in 'whey diet' vs 'casein control diet'
Hist1h4b DOWN in 'whey diet' vs 'casein control diet'
Cd82 DOWN in 'whey diet' vs 'casein control diet'
Dpep1 DOWN in 'soy diet' vs 'casein control diet'
Gsta1 DOWN in 'soy diet' vs 'casein control diet'
Rgs1 UP in 'whey diet' vs 'casein control diet'
Mapk6 DOWN in 'whey diet' vs 'casein control diet'
Aqp9 DOWN in 'whey diet' vs 'casein control diet'
Cth DOWN in 'whey diet' vs 'casein control diet'
Atp1a2 UP in 'whey diet' vs 'casein control diet'
Gsta3 DOWN in 'soy diet' vs 'casein control diet'
Aldob UP in 'soy diet' vs 'casein control diet'
Gsta1 DOWN in 'whey diet' vs 'casein control diet'
Pcp4 UP in 'whey diet' vs 'casein control diet'
Mmp12 UP in 'soy diet' vs 'casein control diet'
Slc4a2 DOWN in 'whey diet' vs 'casein control diet'
Cyp4f1 DOWN in 'soy diet' vs 'casein control diet'
Mep1a DOWN in 'soy diet' vs 'casein control diet'
Enpp3 UP in 'soy diet' vs 'casein control diet'
Pgap2 DOWN in 'whey diet' vs 'casein control diet'
Pc DOWN in 'whey diet' vs 'casein control diet'
Prkg2 DOWN in 'soy diet' vs 'casein control diet'
Prkg2 DOWN in 'whey diet' vs 'casein control diet'
Mep1b DOWN in 'soy diet' vs 'casein control diet'
Mep1a DOWN in 'whey diet' vs 'casein control diet'
Emb DOWN in 'soy diet' vs 'casein control diet'
Cd24 DOWN in 'whey diet' vs 'casein control diet'
Degs2 DOWN in 'whey diet' vs 'casein control diet'
Top2a DOWN in 'whey diet' vs 'casein control diet'
Aldh1a1 DOWN in 'whey diet' vs 'casein control diet'
Adam7 DOWN in 'soy diet' vs 'casein control diet'
Car2 DOWN in 'soy diet' vs 'casein control diet'
Cds1 DOWN in 'whey diet' vs 'casein control diet'
Nexn UP in 'whey diet' vs 'casein control diet'
Tgoln2 DOWN in 'whey diet' vs 'casein control diet'
Ugt1a3 DOWN in 'whey diet' vs 'casein control diet'
Sncg UP in 'whey diet' vs 'casein control diet'
S100a9 UP in 'soy diet' vs 'casein control diet'
Postn UP in 'whey diet' vs 'casein control diet'
Prlr DOWN in 'whey diet' vs 'casein control diet'
Mgst1 UP in 'soy diet' vs 'casein control diet'
Ptprf DOWN in 'whey diet' vs 'casein control diet'
Abcc3 DOWN in 'whey diet' vs 'casein control diet'
Myo5b DOWN in 'whey diet' vs 'casein control diet'
Pld1 DOWN in 'whey diet' vs 'casein control diet'
Fut2 DOWN in 'whey diet' vs 'casein control diet'
Mettl7b DOWN in 'whey diet' vs 'casein control diet'
Fst UP in 'whey diet' vs 'casein control diet'
Bcl2l15 DOWN in 'soy diet' vs 'casein control diet'
Id1 DOWN in 'whey diet' vs 'casein control diet'
Ppa2 DOWN in 'whey diet' vs 'casein control diet'
Schip1 UP in 'whey diet' vs 'casein control diet'
Rbp4 UP in 'whey diet' vs 'casein control diet'
Cacna2d1 UP in 'whey diet' vs 'casein control diet'
Tmbim6 DOWN in 'whey diet' vs 'casein control diet'
Wfdc6a DOWN in 'whey diet' vs 'casein control diet'
Spint2 DOWN in 'whey diet' vs 'casein control diet'
Hnmt UP in 'soy diet' vs 'casein control diet'
Eif2ak3 DOWN in 'whey diet' vs 'casein control diet'
Dcn UP in 'whey diet' vs 'casein control diet'
Gucy1a3 UP in 'whey diet' vs 'casein control diet'
Reg3b UP in 'soy diet' vs 'casein control diet'
Hsd11b2 DOWN in 'whey diet' vs 'casein control diet'
IGG-2A UP in 'soy diet' vs 'casein control diet'
Cyp4f4 DOWN in 'soy diet' vs 'casein control diet'
AABR06023961.1 DOWN in 'soy diet' vs 'casein control diet'
Ugcg DOWN in 'whey diet' vs 'casein control diet'
Dao DOWN in 'whey diet' vs 'casein control diet'
(Sample) disease/azoxymethane induced colon tumor model
Krt20 DOWN in 'whey diet' vs 'casein control diet'
Lum UP in 'soy diet' vs 'casein control diet'
Prdx6 DOWN in 'soy diet' vs 'casein control diet'
Atp12a DOWN in 'whey diet' vs 'casein control diet'
Ebp DOWN in 'whey diet' vs 'casein control diet'
Zg16 DOWN in 'whey diet' vs 'casein control diet'
Defb1 DOWN in 'soy diet' vs 'casein control diet'
Calml4 DOWN in 'whey diet' vs 'casein control diet'
Car4 DOWN in 'whey diet' vs 'casein control diet'
Slc44a4 DOWN in 'whey diet' vs 'casein control diet'
Aldh1a1 DOWN in 'soy diet' vs 'casein control diet'
Slc22a5 DOWN in 'whey diet' vs 'casein control diet'
Clrn3 DOWN in 'whey diet' vs 'casein control diet'
Ms4a8 DOWN in 'whey diet' vs 'casein control diet'
Sult1b1 DOWN in 'whey diet' vs 'casein control diet'
Ptprh DOWN in 'whey diet' vs 'casein control diet'
Ret UP in 'whey diet' vs 'casein control diet'
RGD1559960 DOWN in 'whey diet' vs 'casein control diet'
Cuzd1 DOWN in 'soy diet' vs 'casein control diet'
Nefl UP in 'whey diet' vs 'casein control diet'
S100g DOWN in 'whey diet' vs 'casein control diet'
Tmem171 DOWN in 'whey diet' vs 'casein control diet'
Aqp1 UP in 'whey diet' vs 'casein control diet'
Thy1 UP in 'whey diet' vs 'casein control diet'
Lpl UP in 'soy diet' vs 'casein control diet'
Tac1 UP in 'whey diet' vs 'casein control diet'
Pex11a DOWN in 'soy diet' vs 'casein control diet'
Car2 DOWN in 'whey diet' vs 'casein control diet'
Emp1 DOWN in 'whey diet' vs 'casein control diet'
Sgk1 DOWN in 'whey diet' vs 'casein control diet'
Analysis of 'soy diet' vs 'casein control diet'
Plekho1 UP in 'whey diet' vs 'casein control diet'
Rn50_7_1164.1 DOWN in 'whey diet' vs 'casein control diet'
Ebp DOWN in 'soy diet' vs 'casein control diet'
Akr7a3 DOWN in 'whey diet' vs 'casein control diet'
Muc2 DOWN in 'soy diet' vs 'casein control diet'
RGD1559960 DOWN in 'soy diet' vs 'casein control diet'
Ccl11 UP in 'whey diet' vs 'casein control diet'
Pah DOWN in 'soy diet' vs 'casein control diet'
Ccl2 UP in 'soy diet' vs 'casein control diet'
Defb1 DOWN in 'whey diet' vs 'casein control diet'
LOC680097 DOWN in 'whey diet' vs 'casein control diet'
Vim UP in 'soy diet' vs 'casein control diet'
Pigr DOWN in 'whey diet' vs 'casein control diet'
Slc9a3 DOWN in 'whey diet' vs 'casein control diet'
Pdzk1ip1 DOWN in 'whey diet' vs 'casein control diet'
Slc37a1 DOWN in 'whey diet' vs 'casein control diet'
Pllp DOWN in 'whey diet' vs 'casein control diet'
Anxa2 UP in 'soy diet' vs 'casein control diet'
Cps1 UP in 'soy diet' vs 'casein control diet'
Uchl1 UP in 'whey diet' vs 'casein control diet'
Sst UP in 'whey diet' vs 'casein control diet'
Prune2 UP in 'whey diet' vs 'casein control diet'
IGH-1A UP in 'soy diet' vs 'casein control diet'
AABR06008998.1 DOWN in 'whey diet' vs 'casein control diet'
Lox UP in 'soy diet' vs 'casein control diet'
Cd52 DOWN in 'soy diet' vs 'casein control diet'
Cldn3 DOWN in 'whey diet' vs 'casein control diet'
LOC680097 DOWN in 'soy diet' vs 'casein control diet'
We previously reported that lifetime consumption of soy proteins or whey proteins reduced the incidence of azoxymethane (AOM)-induced colon tumors in rats. To obtain insights into these effects, global gene expression profiles of colons from rats with lifetime ingestion of casein (CAS, control diet), soy protein isolate (SPI), and whey protein hydrolysate (WPH) diets were determined. We identified 31 induced and 49 repressed genes in the proximal colons of the SPI-fed group and 44 induced and 119 repressed genes in the proximal colons of the WPH-fed group, relative to CAS. Hierarchical clustering identified the co-induction or co-repression of multiple genes by SPI and WPH. The differential expression of I-FABP (2.92-, 3.97-fold down-regulated in SPI and WPH fed rats; P = 0.023, P = 0.01, respectively), cyclin D1 (1.61-, 2.42-fold down-regulated in SPI and WPH fed rats; P = 0.033, P = 0.001, respectively), and the c-neu proto-oncogene (2.46-, 4.10-fold down-regulated in SPI and WPH fed rats; P < 0.001, P < 0.001, respectively) mRNAs were confirmed by real-time quantitative RT-PCR. SPI and WPH affected colonic neuro-endocrine gene expression: peptide YY (PYY) and glucagon mRNAs were down-regulated in WPH fed rats, whereas somatostatin mRNA and corresponding circulating protein levels, were enhanced by SPI and WPH. The identification of transcripts co- or differentially-regulated by SPI and WPH diets suggests common as well as unique anti-tumorigenesis mechanisms of action which may involve growth factor, neuroendocrine and immune system genes. SPI and WPH induction of somatostatin, a known anti-proliferative agent for colon cancer cells, would inhibit tumorigenesis Experiment Overall Design: Male Sprague Dawley rats, fed one of the three purified diets, were studied at 40 weeks after AOM injection and when tumors had developed in some animals of each group. Total RNA, purified from non-tumor tissue within the proximal half of each colon, was used to prepare biotinylated probes, which were hybridized to Affymetrix RG_U34A rat microarrays.
Epb41l4b DOWN in 'whey diet' vs 'casein control diet'
Cd55 DOWN in 'whey diet' vs 'casein control diet'
Apoa1 UP in 'soy diet' vs 'casein control diet'
Il18 DOWN in 'whey diet' vs 'casein control diet'
Apob UP in 'soy diet' vs 'casein control diet'
Slc25a10 DOWN in 'soy diet' vs 'casein control diet'
Gcg DOWN in 'whey diet' vs 'casein control diet'
Tor1aip2 DOWN in 'whey diet' vs 'casein control diet'
Alb UP in 'whey diet' vs 'casein control diet'
Insig1 DOWN in 'whey diet' vs 'casein control diet'
Pah DOWN in 'whey diet' vs 'casein control diet'
Cuzd1 DOWN in 'whey diet' vs 'casein control diet'
Atp1b1 DOWN in 'whey diet' vs 'casein control diet'
Ppp1r1a UP in 'whey diet' vs 'casein control diet'
Kcnk1 DOWN in 'whey diet' vs 'casein control diet'
Lum UP in 'whey diet' vs 'casein control diet'
Spink8 DOWN in 'soy diet' vs 'casein control diet'
Rtn1 UP in 'whey diet' vs 'casein control diet'
Aldh1a7 DOWN in 'whey diet' vs 'casein control diet'
S100b UP in 'whey diet' vs 'casein control diet'
Fabp5 UP in 'whey diet' vs 'casein control diet'
Adh1 DOWN in 'whey diet' vs 'casein control diet'
Fn1 UP in 'whey diet' vs 'casein control diet'
Pdzk1ip1 DOWN in 'soy diet' vs 'casein control diet'
Slc35a1 DOWN in 'whey diet' vs 'casein control diet'
Fabp1 DOWN in 'whey diet' vs 'casein control diet'
Ptpn3 DOWN in 'soy diet' vs 'casein control diet'
Scg5 UP in 'whey diet' vs 'casein control diet'
Frk DOWN in 'whey diet' vs 'casein control diet'
Nefm UP in 'whey diet' vs 'casein control diet'
Lgals3 DOWN in 'whey diet' vs 'casein control diet'
Spp1 UP in 'soy diet' vs 'casein control diet'
Tmigd1 DOWN in 'whey diet' vs 'casein control diet'
Foxa3 DOWN in 'whey diet' vs 'casein control diet'
Gclm DOWN in 'whey diet' vs 'casein control diet'
Ptgds DOWN in 'soy diet' vs 'casein control diet'
Myl1 UP in 'whey diet' vs 'casein control diet'
Tmigd1 DOWN in 'soy diet' vs 'casein control diet'
Sri DOWN in 'whey diet' vs 'casein control diet'
Mgst2 DOWN in 'whey diet' vs 'casein control diet'
Ap1s3 DOWN in 'whey diet' vs 'casein control diet'
Slc16a1 DOWN in 'whey diet' vs 'casein control diet'
Efna1 DOWN in 'whey diet' vs 'casein control diet'
Guca2a DOWN in 'soy diet' vs 'casein control diet'
LOC290595 DOWN in 'whey diet' vs 'casein control diet'
Ugdh DOWN in 'whey diet' vs 'casein control diet'
Mgp UP in 'soy diet' vs 'casein control diet'
Dpyd DOWN in 'whey diet' vs 'casein control diet'