Tbx20 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Sox11 UP in 'Setd2 knock out' vs 'wild type genotype'
Nxt2 UP in 'Setd2 knock out' vs 'wild type genotype'
Analysis of 'Setd2 knock out' vs 'wild type genotype'
Hemk1 UP in 'Setd2 knock out' vs 'wild type genotype'
4930444M15Rik DOWN in 'Setd2 knock out' vs 'wild type genotype'
Mep1b UP in 'Setd2 knock out' vs 'wild type genotype'
B830012L14Rik DOWN in 'Setd2 knock out' vs 'wild type genotype'
Aste1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Esrp1 UP in 'Setd2 knock out' vs 'wild type genotype'
Lztfl1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Piwil2 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Mt2 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Slc7a6 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Ccnb1ip1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Trim12a DOWN in 'Setd2 knock out' vs 'wild type genotype'
T UP in 'Setd2 knock out' vs 'wild type genotype'
Grik3 UP in 'Setd2 knock out' vs 'wild type genotype'
Nlrx1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Ciapin1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Efcab11 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Ttk UP in 'Setd2 knock out' vs 'wild type genotype'
Ttc39c DOWN in 'Setd2 knock out' vs 'wild type genotype'
Cubn DOWN in 'Setd2 knock out' vs 'wild type genotype'
Uty UP in 'Setd2 knock out' vs 'wild type genotype'
Dock5 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Gata6 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Pdlim5 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Triml1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Supt7l UP in 'Setd2 knock out' vs 'wild type genotype'
Gm19427 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Nefm UP in 'Setd2 knock out' vs 'wild type genotype'
Usp14 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Coro2b DOWN in 'Setd2 knock out' vs 'wild type genotype'
Fbp2 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Cyyr1 UP in 'Setd2 knock out' vs 'wild type genotype'
Serpina3m DOWN in 'Setd2 knock out' vs 'wild type genotype'
Ppcdc DOWN in 'Setd2 knock out' vs 'wild type genotype'
Mettl7a1 UP in 'Setd2 knock out' vs 'wild type genotype'
Prickle1 UP in 'Setd2 knock out' vs 'wild type genotype'
Gbp2 UP in 'Setd2 knock out' vs 'wild type genotype'
Zfp386 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Eif2s3y UP in 'Setd2 knock out' vs 'wild type genotype'
Cthrc1 UP in 'Setd2 knock out' vs 'wild type genotype'
Med1 UP in 'Setd2 knock out' vs 'wild type genotype'
Fam25c DOWN in 'Setd2 knock out' vs 'wild type genotype'
Rpl39l UP in 'Setd2 knock out' vs 'wild type genotype'
Tsix DOWN in 'Setd2 knock out' vs 'wild type genotype'
Esco1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Hmgb2 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Myo1f DOWN in 'Setd2 knock out' vs 'wild type genotype'
Mid1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Mtus1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Nupr1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Aass DOWN in 'Setd2 knock out' vs 'wild type genotype'
Zfp946 UP in 'Setd2 knock out' vs 'wild type genotype'
Bcl11a UP in 'Setd2 knock out' vs 'wild type genotype'
4930427A07Rik DOWN in 'Setd2 knock out' vs 'wild type genotype'
Ap1m2 UP in 'Setd2 knock out' vs 'wild type genotype'
Scn3a DOWN in 'Setd2 knock out' vs 'wild type genotype'
Imp4 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Mt1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Dnmt3b UP in 'Setd2 knock out' vs 'wild type genotype'
Galc DOWN in 'Setd2 knock out' vs 'wild type genotype'
Cep162 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Car6 DOWN in 'Setd2 knock out' vs 'wild type genotype'
RP24-540G19.3 UP in 'Setd2 knock out' vs 'wild type genotype'
Meg3 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Fut10 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Cdc23 UP in 'Setd2 knock out' vs 'wild type genotype'
Tex40 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Sult6b1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Parp3 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Rpl3l DOWN in 'Setd2 knock out' vs 'wild type genotype'
Ddx3y UP in 'Setd2 knock out' vs 'wild type genotype'
Dkk1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Tmeff2 UP in 'Setd2 knock out' vs 'wild type genotype'
Zcchc3 UP in 'Setd2 knock out' vs 'wild type genotype'
Rlbp1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Frmd4b UP in 'Setd2 knock out' vs 'wild type genotype'
Kif5b DOWN in 'Setd2 knock out' vs 'wild type genotype'
Pts DOWN in 'Setd2 knock out' vs 'wild type genotype'
Zeb1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Atp7a DOWN in 'Setd2 knock out' vs 'wild type genotype'
Zfp42 DOWN in 'Setd2 knock out' vs 'wild type genotype'
AI662270 UP in 'Setd2 knock out' vs 'wild type genotype'
SETD2/HYPB has been known as a histone H3K36 specific methyltransferase. However, its roles in physiology such as development and cellular function remain unclear. In this study, using mESCs as cellular model, we show that Setd2 mainly regulates differentiation of murine embryonic stem cells (mESCs) towards primitive endoderm. This study aimed at exploring how did Setd2 regulate primitive endoderm. differentiation. We used microarrays to detail the global programme of gene expression controled by setd2, which is required for endoderm differentiation. Wild type and Setd2 knockout mESCs were selected for RNA extraction and hybridization on Affymetrix GeneChipÃÂ® mouse genome 430 2.0 arrays. We sought to obtain some deregulated genes, which were required for primitive endoderm differentiation. For comparison, three biological repeats of each were performed.
Atm DOWN in 'Setd2 knock out' vs 'wild type genotype'
Rian DOWN in 'Setd2 knock out' vs 'wild type genotype'
Paip1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Adcy7 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Srgn DOWN in 'Setd2 knock out' vs 'wild type genotype'
Ints10 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Tfpi DOWN in 'Setd2 knock out' vs 'wild type genotype'
Chic1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Jakmip2 UP in 'Setd2 knock out' vs 'wild type genotype'
Aoah UP in 'Setd2 knock out' vs 'wild type genotype'
Tmem40 UP in 'Setd2 knock out' vs 'wild type genotype'
Robo4 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Pdgfra DOWN in 'Setd2 knock out' vs 'wild type genotype'
(Sample) cell type/mouse embryonic stem cell
Gm15698 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Riok3 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Mpi DOWN in 'Setd2 knock out' vs 'wild type genotype'
Dab2 DOWN in 'Setd2 knock out' vs 'wild type genotype'
B3galt6 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Kifc3 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Fam131b UP in 'Setd2 knock out' vs 'wild type genotype'
Ccdc113 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Gipc2 UP in 'Setd2 knock out' vs 'wild type genotype'
Fundc2 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Prkar2a DOWN in 'Setd2 knock out' vs 'wild type genotype'
Ubd UP in 'Setd2 knock out' vs 'wild type genotype'
Farsa DOWN in 'Setd2 knock out' vs 'wild type genotype'
Sox17 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Stard4 UP in 'Setd2 knock out' vs 'wild type genotype'
Bbs2 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Mmrn2 DOWN in 'Setd2 knock out' vs 'wild type genotype'
(Factor value) GENOTYPE/wild type genotype
Mapk8 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Tceanc2 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Adam23 UP in 'Setd2 knock out' vs 'wild type genotype'
Yars DOWN in 'Setd2 knock out' vs 'wild type genotype'
2810417H13Rik DOWN in 'Setd2 knock out' vs 'wild type genotype'
Rapgef5 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Galnt3 UP in 'Setd2 knock out' vs 'wild type genotype'
Tex13 UP in 'Setd2 knock out' vs 'wild type genotype'
Rnf170 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Col4a1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Mal2 UP in 'Setd2 knock out' vs 'wild type genotype'
Mras DOWN in 'Setd2 knock out' vs 'wild type genotype'
Kcnj3 UP in 'Setd2 knock out' vs 'wild type genotype'
Timmdc1 UP in 'Setd2 knock out' vs 'wild type genotype'
1700042O10Rik DOWN in 'Setd2 knock out' vs 'wild type genotype'
Rhox5 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Lama3 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Trim34a DOWN in 'Setd2 knock out' vs 'wild type genotype'
Elavl1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Nedd4 UP in 'Setd2 knock out' vs 'wild type genotype'
1700019A02Rik DOWN in 'Setd2 knock out' vs 'wild type genotype'
Crisp1 UP in 'Setd2 knock out' vs 'wild type genotype'
Fgfbp1 DOWN in 'Setd2 knock out' vs 'wild type genotype'
Myo7a DOWN in 'Setd2 knock out' vs 'wild type genotype'
Zfp874a UP in 'Setd2 knock out' vs 'wild type genotype'