(Assay) PBA: LMid_D4_LD-BPA_75-12
type: Assay
identifier: PBA: LMid_D4_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: Ctrl_A2_LD-Gen_75-33
type: Assay
identifier: PBA: Ctrl_A2_LD-Gen_75-33
has participant: A-AFFY-18

(Assay) PBA: 40r_EE_LDResp_M9_1576-171
type: Assay
identifier: PBA: 40r_EE_LDResp_M9_1576-171
has participant: A-AFFY-25

1387174_a_at
type: EFO_0005072
part of: A-AFFY-25

(Assay) PBA: LMid_D7_LD-BPA_75-12
type: Assay
identifier: PBA: LMid_D7_LD-BPA_75-12
has participant: A-AFFY-18

Cpa1
type: EnsemblDatabaseReference

(Assay) PBA: Mid_E10_LD-Gen_75-33
type: Assay
identifier: PBA: Mid_E10_LD-Gen_75-33
has participant: A-AFFY-18

Analysis of '100 milligram per kilogram per day; genestein' vs 'none' on 'Affymetrix RG_U34A Array'
type: MicroarrayDifferentialExpressionAnalysis

(Assay) PBA: EE_Y6t_Ctrl-165
type: Assay
identifier: PBA: EE_Y6t_Ctrl-165
has participant: A-AFFY-18

(Sample) developmental stage/fetus
type: EFO_0001323
property type: developmental stage
property value: fetus

(Assay) PBA: Low_C6_LD-BPA_75-12
type: Assay
identifier: PBA: Low_C6_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: Low_C8_LD-BPA_75-12
type: Assay
identifier: PBA: Low_C8_LD-BPA_75-12
has participant: A-AFFY-18

Star DOWN in '400 milligram per kilogram per day; bisphenol A' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.42140540790868
p value: 0.0260050426531606
refers to: AB001349_at
refers to: Star
t statistic: -6.86957330943403

(Factor value) COMPOUND/bisphenol A 0.5
type: CHEBI_33216
property type: COMPOUND
property value: bisphenol A 0.5

Hao2 UP in '100 milligram per kilogram per day; genestein' vs 'none' on 'Affymetrix RG_U34A Array'
type: IncreasedDifferentialExpressionRatio
fold change: 1.12345257442539
p value: 0.00203116411804412
refers to: rc_AI232087_at
refers to: Hao2
t statistic: 8.80993167305309

(Assay) PBA: Mid_E3_LD-Gen_75-33
type: Assay
identifier: PBA: Mid_E3_LD-Gen_75-33
has participant: A-AFFY-18

Cpa1 DOWN in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: DecreasedDifferentialExpressionRatio
fold change: -1.78807243640171
p value: 1.10649909045922E-4
refers to: 1369657_at
refers to: Cpa1
t statistic: -9.71320427977333

(Assay) PBA: 13_EE_LDResp_C3_1576-171
type: Assay
identifier: PBA: 13_EE_LDResp_C3_1576-171
has participant: A-AFFY-25

(Assay) PBA: EE_B2t_Ctrl-165
type: Assay
identifier: PBA: EE_B2t_Ctrl-165
has participant: A-AFFY-18

1367855_at
type: EFO_0005072
part of: A-AFFY-25

(Assay) PBA: MH_F6_LD-Gen_75-33
type: Assay
identifier: PBA: MH_F6_LD-Gen_75-33
has participant: A-AFFY-18

(Assay) PBA: 31_EE_LDResp_C6_1576-171
type: Assay
identifier: PBA: 31_EE_LDResp_C6_1576-171
has participant: A-AFFY-25

1386956_at
type: EFO_0005072
part of: A-AFFY-25

(Assay) PBA: EE_Y4t_Ctrl-165
type: Assay
identifier: PBA: EE_Y4t_Ctrl-165
has participant: A-AFFY-18

(Assay) PBA: 36_EE_LDResp_HH12_1576-171
type: Assay
identifier: PBA: 36_EE_LDResp_HH12_1576-171
has participant: A-AFFY-25

Analysis of '400 milligram per kilogram per day; bisphenol A' vs 'none' on 'Affymetrix RG_U34A Array'
type: MicroarrayDifferentialExpressionAnalysis

(Assay) PBA: 28_EE_LDResp_M7_1576-171
type: Assay
identifier: PBA: 28_EE_LDResp_M7_1576-171
has participant: A-AFFY-25

(Assay) PBA: MH_F5_LD-Gen_75-33
type: Assay
identifier: PBA: MH_F5_LD-Gen_75-33
has participant: A-AFFY-18

Cyp11a1 DOWN in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: DecreasedDifferentialExpressionRatio
fold change: -1.25335757931735
p value: 4.652893627256E-5
refers to: Cyp11a1
refers to: 1368468_at
t statistic: -10.7272177940508

1387125_at
type: EFO_0005072
part of: A-AFFY-25

(Assay) PBA: LL_B5_LD-BPA_75-12
type: Assay
identifier: PBA: LL_B5_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: 17_EE_LDResp_H4_1576-171
type: Assay
identifier: PBA: 17_EE_LDResp_H4_1576-171
has participant: A-AFFY-25

(Assay) PBA: EE_P2t_Ctrl-165
type: Assay
identifier: PBA: EE_P2t_Ctrl-165
has participant: A-AFFY-18

(Sample) age/20
type: EFO_0000001
property type: age
property value: 20

(Assay) PBA: High_G6_LD-Gen_75-33
type: Assay
identifier: PBA: High_G6_LD-Gen_75-33
has participant: A-AFFY-18

A-AFFY-25
type: EFO_0000269

(Assay) PBA: 9r_EE_LDResp_L3_1576-171
type: Assay
identifier: PBA: 9r_EE_LDResp_L3_1576-171
has participant: A-AFFY-25

(Assay) PBA: 7r_EE_LDResp_C2_1576-171
type: Assay
identifier: PBA: 7r_EE_LDResp_C2_1576-171
has participant: A-AFFY-25

(Factor value) COMPOUND/17a-ethynylestradiol 0.000001
type: CHEBI 4903
property type: COMPOUND
property value: 17a-ethynylestradiol 0.000001

(Assay) PBA: EE_Y5t_Ctrl-165
type: Assay
identifier: PBA: EE_Y5t_Ctrl-165
has participant: A-AFFY-18

1374104_at
type: EFO_0005072
part of: A-AFFY-25

Hbe1
type: EnsemblDatabaseReference

J05156_s_at
type: EFO_0005072
part of: A-AFFY-18

(Factor value) COMPOUND/none
type: EFO_0001461
property type: COMPOUND
property value: none

(Assay) PBA: High_G7_LD-BPA_75-12
type: Assay
identifier: PBA: High_G7_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: Ctrl_A7_LD-BPA_75-12
type: Assay
identifier: PBA: Ctrl_A7_LD-BPA_75-12
has participant: A-AFFY-18

S100a9 UP in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: IncreasedDifferentialExpressionRatio
fold change: 1.4045316405198
p value: 0.0025966768610107
refers to: S100a9
refers to: 1387125_at
t statistic: 7.0080449568463

(Assay) PBA: LMid_D2_LD-BPA_75-12
type: Assay
identifier: PBA: LMid_D2_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: EE_B3t_Ctrl-165
type: Assay
identifier: PBA: EE_B3t_Ctrl-165
has participant: A-AFFY-18

(Assay) PBA: 38_EE_LDResp_LL10_1576-171
type: Assay
identifier: PBA: 38_EE_LDResp_LL10_1576-171
has participant: A-AFFY-25

Scarb1 DOWN in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: DecreasedDifferentialExpressionRatio
fold change: -1.08795582070792
p value: 8.64394223276046E-4
refers to: Scarb1
refers to: 1367855_at
t statistic: -7.97160770466515

(Assay) PBA: Mid_F6_LD-BPA_75-12
type: Assay
identifier: PBA: Mid_F6_LD-BPA_75-12
has participant: A-AFFY-18

Svs5 DOWN in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: DecreasedDifferentialExpressionRatio
fold change: -2.57200186074133
p value: 2.59325276155535E-5
refers to: Svs5
refers to: 1367615_at
t statistic: -11.7229691549764

1367774_at
type: EFO_0005072
part of: A-AFFY-25

Scarb1
type: EnsemblDatabaseReference

(Assay) PBA: High_G2_LD-Gen_75-33
type: Assay
identifier: PBA: High_G2_LD-Gen_75-33
has participant: A-AFFY-18

S100a9
type: EnsemblDatabaseReference

AB001349_at
type: EFO_0005072
part of: A-AFFY-18

(Assay) PBA: EE_P1t_Ctrl-165
type: Assay
identifier: PBA: EE_P1t_Ctrl-165
has participant: A-AFFY-18

(Assay) PBA: MH_F8_LD-Gen_75-33
type: Assay
identifier: PBA: MH_F8_LD-Gen_75-33
has participant: A-AFFY-18

(Assay) PBA: MH_F2_LD-Gen_75-33
type: Assay
identifier: PBA: MH_F2_LD-Gen_75-33
has participant: A-AFFY-18

(Assay) PBA: EE_G7t_Ctrl-165
type: Assay
identifier: PBA: EE_G7t_Ctrl-165
has participant: A-AFFY-18

(Sample) organism part/epididymis
type: UBERON_0001301
property type: organism part
property value: epididymis

Myom2
type: EnsemblDatabaseReference

(Assay) PBA: Mid_F5_LD-BPA_75-12
type: Assay
identifier: PBA: Mid_F5_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: EE_B1t_Ctrl-165
type: Assay
identifier: PBA: EE_B1t_Ctrl-165
has participant: A-AFFY-18

(Factor value) COMPOUND/bisphenol A 0.02
type: CHEBI_33216
property type: COMPOUND
property value: bisphenol A 0.02

(Factor value) COMPOUND/bisphenol A 400
type: CHEBI_33216
property type: COMPOUND
property value: bisphenol A 400

Creg1 UP in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: IncreasedDifferentialExpressionRatio
fold change: 1.52092290958092
p value: 9.73755375630634E-6
refers to: Creg1
refers to: 1375428_at
t statistic: 12.9713602769903

(Assay) PBA: Ctrl_A9_LD-Gen_75-33
type: Assay
identifier: PBA: Ctrl_A9_LD-Gen_75-33
has participant: A-AFFY-18

(Factor value) COMPOUND/genestein 1
type: EFO_0000001
property type: COMPOUND
property value: genestein 1

(Assay) PBA: 33_EE_LDResp_L7_1576-171
type: Assay
identifier: PBA: 33_EE_LDResp_L7_1576-171
has participant: A-AFFY-25

(Assay) PBA: LMid_D3_LD-BPA_75-12
type: Assay
identifier: PBA: LMid_D3_LD-BPA_75-12
has participant: A-AFFY-18

AB006007_s_at
type: EFO_0005072
part of: A-AFFY-18

(Assay) PBA: Ctrl_A5_LD-BPA_75-12
type: Assay
identifier: PBA: Ctrl_A5_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: 6_EE_LDResp_HH2_1576-171
type: Assay
identifier: PBA: 6_EE_LDResp_HH2_1576-171
has participant: A-AFFY-25

Calb2
type: EnsemblDatabaseReference

(Assay) PBA: 34_EE_LDResp_M8_1576-171
type: Assay
identifier: PBA: 34_EE_LDResp_M8_1576-171
has participant: A-AFFY-25

1369657_at
type: EFO_0005072
part of: A-AFFY-25

1375428_at
type: EFO_0005072
part of: A-AFFY-25

rc_AI232087_at
type: EFO_0005072
part of: A-AFFY-18

(Factor value) COMPOUND/genestein 10
type: EFO_0000001
property type: COMPOUND
property value: genestein 10

Cpa1 DOWN in '400 milligram per kilogram per day; bisphenol A' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.95856209217133
p value: 0.00216814846843952
refers to: J00713mRNA_at
refers to: Cpa1
t statistic: -10.5334996302667

(Factor value) COMPOUND/bisphenol A 50
type: CHEBI_33216
property type: COMPOUND
property value: bisphenol A 50

(Factor value) COMPOUND/17a-ethynylestradiol 10
type: CHEBI 4903
property type: COMPOUND
property value: 17a-ethynylestradiol 10

Cyp17a1
type: EnsemblDatabaseReference

Gsta1
type: EnsemblDatabaseReference

Cyp17a1
type: EnsemblDatabaseReference

(Factor value) COMPOUND/genestein 0.1
type: EFO_0000001
property type: COMPOUND
property value: genestein 0.1

(Assay) PBA: EE_P5t_Ctrl-165
type: Assay
identifier: PBA: EE_P5t_Ctrl-165
has participant: A-AFFY-18

M21208mRNA_s_at
type: EFO_0005072
part of: A-AFFY-18

1381968_at
type: EFO_0005072
part of: A-AFFY-25

Creg1
type: EnsemblDatabaseReference

(Assay) PBA: LM_D1_LD-Gen_75-33
type: Assay
identifier: PBA: LM_D1_LD-Gen_75-33
has participant: A-AFFY-18

Star
type: EnsemblDatabaseReference

(Assay) PBA: LMid_D5_LD-BPA_75-12
type: Assay
identifier: PBA: LMid_D5_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: 12_EE_LDResp_HH6_1576-171
type: Assay
identifier: PBA: 12_EE_LDResp_HH6_1576-171
has participant: A-AFFY-25

(Assay) PBA: LL_B4_LD-BPA_75-12
type: Assay
identifier: PBA: LL_B4_LD-BPA_75-12
has participant: A-AFFY-18

(Sample) sex/male
type: EFO_0001266
property type: sex
property value: male

Svs5
type: EnsemblDatabaseReference

1367615_at
type: EFO_0005072
part of: A-AFFY-25

Insl3
type: EnsemblDatabaseReference

(Assay) PBA: LL_B2_LD-Gen_75-33
type: Assay
identifier: PBA: LL_B2_LD-Gen_75-33
has participant: A-AFFY-18

Star DOWN in '10 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.11780176290937
p value: 4.76286079595844E-6
refers to: Star
refers to: AB001349_at
t statistic: -12.3867050525291

(Assay) PBA: LL_B8_LD-Gen_75-33
type: Assay
identifier: PBA: LL_B8_LD-Gen_75-33
has participant: A-AFFY-18

X01115_at
type: EFO_0005072
part of: A-AFFY-18

(Assay) PBA: Mid_E5_LD-Gen_75-33
type: Assay
identifier: PBA: Mid_E5_LD-Gen_75-33
has participant: A-AFFY-18

Cyp17a1 DOWN in '10 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -2.71011711751185
p value: 7.09644980481099E-6
refers to: Cyp17a1
refers to: M21208mRNA_s_at
t statistic: -11.6061156084807

(Assay) PBA: 23_EE_LDResp_H5_1576-171
type: Assay
identifier: PBA: 23_EE_LDResp_H5_1576-171
has participant: A-AFFY-25

(Assay) PBA: High_G4_LD-BPA_75-12
type: Assay
identifier: PBA: High_G4_LD-BPA_75-12
has participant: A-AFFY-18

(Factor value) COMPOUND/bisphenol A 0.002
type: CHEBI_33216
property type: COMPOUND
property value: bisphenol A 0.002

X56326cds_at
type: EFO_0005072
part of: A-AFFY-18

A-AFFY-18
type: EFO_0000269

(Assay) PBA: EE_Y2t_Ctrl-165
type: Assay
identifier: PBA: EE_Y2t_Ctrl-165
has participant: A-AFFY-18

(Assay) PBA: 37r_EE_LDResp_C7_1576-171
type: Assay
identifier: PBA: 37r_EE_LDResp_C7_1576-171
has participant: A-AFFY-25

Cpa1 DOWN in '10 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.39853122111594
p value: 4.76286079595844E-6
refers to: Cpa1
refers to: J00713mRNA_at
t statistic: -12.3798700167861

(Assay) PBA: Low_C4_LD-BPA_75-12
type: Assay
identifier: PBA: Low_C4_LD-BPA_75-12
has participant: A-AFFY-18

Insl3 DOWN in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: DecreasedDifferentialExpressionRatio
fold change: -1.74501540207955
p value: 3.61432939746732E-5
refers to: Insl3
refers to: 1388241_at
t statistic: -11.1753508873535

(Assay) PBA: 2r_EE_LDResp_LL1_1576-171
type: Assay
identifier: PBA: 2r_EE_LDResp_LL1_1576-171
has participant: A-AFFY-25

(Assay) PBA: Ctrl_A8_LD-BPA_75-12
type: Assay
identifier: PBA: Ctrl_A8_LD-BPA_75-12
has participant: A-AFFY-18

Hao2
type: EnsemblDatabaseReference

1387133_at
type: EFO_0005072
part of: A-AFFY-25

Cldn5
type: EnsemblDatabaseReference

(Assay) PBA: EE_G6t_Ctrl-165
type: Assay
identifier: PBA: EE_G6t_Ctrl-165
has participant: A-AFFY-18

(Assay) PBA: Mid_F2_LD-BPA_75-12
type: Assay
identifier: PBA: Mid_F2_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: Low_C5_LD-BPA_75-12
type: Assay
identifier: PBA: Low_C5_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: 35r_EE_LDResp_H7_1576-171
type: Assay
identifier: PBA: 35r_EE_LDResp_H7_1576-171
has participant: A-AFFY-25

(Assay) PBA: High_G7_LD-Gen_75-33
type: Assay
identifier: PBA: High_G7_LD-Gen_75-33
has participant: A-AFFY-18

(Assay) PBA: EE_Y1t_Ctrl-165
type: Assay
identifier: PBA: EE_Y1t_Ctrl-165
has participant: A-AFFY-18

(Assay) PBA: High_G1_LD-BPA_75-12
type: Assay
identifier: PBA: High_G1_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: 4_EE_LDResp_M2_1576-171
type: Assay
identifier: PBA: 4_EE_LDResp_M2_1576-171
has participant: A-AFFY-25

Star DOWN in '100 milligram per kilogram per day; genestein' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.20943718489475
p value: 0.00203116411804412
refers to: Star
refers to: AB001349_at
t statistic: -8.97263932854388

(Assay) PBA: Low_C3_LD-BPA_75-12
type: Assay
identifier: PBA: Low_C3_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: High_G5_LD-BPA_75-12
type: Assay
identifier: PBA: High_G5_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: Ctrl_A5_LD-Gen_75-33
type: Assay
identifier: PBA: Ctrl_A5_LD-Gen_75-33
has participant: A-AFFY-18

(Assay) PBA: LL_B1_LD-Gen_75-33
type: Assay
identifier: PBA: LL_B1_LD-Gen_75-33
has participant: A-AFFY-18

Star DOWN in '10 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.12622229738554
p value: 9.31992993385718E-4
refers to: Star
refers to: AB006007_s_at
t statistic: -7.03463560318882

Cpa1
type: EnsemblDatabaseReference

1388241_at
type: EFO_0005072
part of: A-AFFY-25

J00713mRNA_at
type: EFO_0005072
part of: A-AFFY-18

(Assay) PBA: Mid_E6_LD-Gen_75-33
type: Assay
identifier: PBA: Mid_E6_LD-Gen_75-33
has participant: A-AFFY-18

Cyp17a1 DOWN in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: DecreasedDifferentialExpressionRatio
fold change: -3.10084529409608
p value: 3.61432939746732E-5
refers to: Cyp17a1
refers to: 1387123_at
t statistic: -11.1507990966029

Analysis of '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: MicroarrayDifferentialExpressionAnalysis

Cyp11a1
type: EnsemblDatabaseReference

Creg1 UP in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: IncreasedDifferentialExpressionRatio
fold change: 1.45338722508121
p value: 3.15799441068866E-6
refers to: Creg1
refers to: 1381968_at
t statistic: 15.6400031586883

1368406_at
type: EFO_0005072
part of: A-AFFY-25

Cyp11a1
type: EnsemblDatabaseReference

(Assay) PBA: 20_EE_LDResp_LL5_1576-171
type: Assay
identifier: PBA: 20_EE_LDResp_LL5_1576-171
has participant: A-AFFY-25

Star DOWN in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: DecreasedDifferentialExpressionRatio
fold change: -2.18511997332492
p value: 3.15799441068866E-6
refers to: 1387174_a_at
refers to: Star
t statistic: -14.7458549252156

Rattus norvegicus
type: OBI_0100026

(Factor value) COMPOUND/genestein 100
type: EFO_0000001
property type: COMPOUND
property value: genestein 100

(Assay) PBA: LL_B1_LD-BPA_75-12
type: Assay
identifier: PBA: LL_B1_LD-BPA_75-12
has participant: A-AFFY-18

Gsta1 DOWN in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: DecreasedDifferentialExpressionRatio
fold change: -1.0107915261831
p value: 5.84661702156523E-5
refers to: Gsta1
refers to: 1367774_at
t statistic: -10.3039130574851

Star DOWN in '400 milligram per kilogram per day; bisphenol A' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.52074817274573
p value: 0.0393415886663138
refers to: Star
refers to: AB006007_s_at
t statistic: -6.42572647154343

(Assay) PBA: 27_EE_LDResp_L6_1576-171
type: Assay
identifier: PBA: 27_EE_LDResp_L6_1576-171
has participant: A-AFFY-25

(Assay) PBA: 39_EE_LDResp_L8_1576-171
type: Assay
identifier: PBA: 39_EE_LDResp_L8_1576-171
has participant: A-AFFY-25

(Assay) PBA: 25_EE_LDResp_C5_1576-171
type: Assay
identifier: PBA: 25_EE_LDResp_C5_1576-171
has participant: A-AFFY-25

Cyp17a1 DOWN in '400 milligram per kilogram per day; bisphenol A' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -3.53048513485879
p value: 7.14815123774252E-4
refers to: Cyp17a1
refers to: M21208mRNA_s_at
t statistic: -12.8056519381045

(Assay) PBA: 3r_EE_LDResp_L2_1576-171
type: Assay
identifier: PBA: 3r_EE_LDResp_L2_1576-171
has participant: A-AFFY-25

S100a9
type: EnsemblDatabaseReference

(Assay) PBA: 29_EE_LDResp_H6_1576-171
type: Assay
identifier: PBA: 29_EE_LDResp_H6_1576-171
has participant: A-AFFY-25

(Factor value) COMPOUND/17a-ethynylestradiol 0.0001
type: CHEBI 4903
property type: COMPOUND
property value: 17a-ethynylestradiol 0.0001

Svs5 DOWN in '10 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.76959981206876
p value: 1.60666937552718E-5
refers to: X01115_at
refers to: Svs5
t statistic: -10.6086994436556

(Assay) PBA: 19_EE_LDResp_C4_1576-171
type: Assay
identifier: PBA: 19_EE_LDResp_C4_1576-171
has participant: A-AFFY-25

(Assay) PBA: Ctrl_A8_LD-Gen_75-33
type: Assay
identifier: PBA: Ctrl_A8_LD-Gen_75-33
has participant: A-AFFY-18

Myom2
type: EnsemblDatabaseReference

Star DOWN in '100 milligram per kilogram per day; genestein' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.07797303296011
p value: 0.0114971512348786
refers to: Star
refers to: AB006007_s_at
t statistic: -7.14686264777719

Hbe1
type: EnsemblDatabaseReference

(Assay) PBA: EE_G1t_Ctrl-165
type: Assay
identifier: PBA: EE_G1t_Ctrl-165
has participant: A-AFFY-18

(Factor value) COMPOUND/17a-ethynylestradiol 0.00001
type: CHEBI 4903
property type: COMPOUND
property value: 17a-ethynylestradiol 0.00001

(Assay) PBA: LL_B7_LD-BPA_75-12
type: Assay
identifier: PBA: LL_B7_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: LL_B6_LD-Gen_75-33
type: Assay
identifier: PBA: LL_B6_LD-Gen_75-33
has participant: A-AFFY-18

(Factor value) COMPOUND/17a-ethynylestradiol 1
type: CHEBI 4903
property type: COMPOUND
property value: 17a-ethynylestradiol 1

(Sample) organism/Rattus norvegicus
type: Rattus norvegicus
property type: organism
property value: Rattus norvegicus

(Assay) PBA: LL_B3_LD-BPA_75-12
type: Assay
identifier: PBA: LL_B3_LD-BPA_75-12
has participant: A-AFFY-18

Star DOWN in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: DecreasedDifferentialExpressionRatio
fold change: -2.35809244029342
p value: 3.15799441068866E-6
refers to: 1368406_at
refers to: Star
t statistic: -14.6279110248386

(Assay) PBA: 26r_EE_LDResp_LL6_1576-171
type: Assay
identifier: PBA: 26r_EE_LDResp_LL6_1576-171
has participant: A-AFFY-25

(Assay) PBA: 32_EE_LDResp_LL9_1576-171
type: Assay
identifier: PBA: 32_EE_LDResp_LL9_1576-171
has participant: A-AFFY-25

E-TABM-12
type: microarray 1colour mrna differential
RO_0002162: Rattus norvegicus
description: The purpose of this study was to determine 1) the transcriptional program elicited by exposure to three estrogen receptor (ER) agonists: 17 a-ethynyl estradiol (EE), genistein (Ges) and bisphenol A (BPA) during fetal development of the rat testis and epididymis; and 2) whether very low dosages of estrogens (evaluated over five orders of magnitude of dosage) produce unexpected changes in gene expression (i.e., a non-monotonic dose-response curve). In three independently conducted experiments, Sprague-Dawley rats were dosed (s.c.) with 0.001-10mg EE/kg/day, 0.001-100 mg Ges/kg/day or 0.002-400mg BPA/kg/day. While morphological changes in the developing reproductive system were not observed, the gene expression profile of target tissues were modified in a dose-responsive manner. Independent dose-response analyses of the three studies identified 56 genes that are significantly modified by EE, 28 genes by Ges and 15 genes by BPA (out of 8740). Even more genes were observed to be significantly changed when only the high dose is compared with all lower doses: 141, 46 and 67 genes, respectively. Global analyses aimed at detecting genes consistently modified by all of the chemicals identified 52 genes whose expression changed in the same direction across the three chemicals. The dose-response curve for gene expression changes was monotonic for each chemical, with both the number of genes significantly changed and the magnitude of change, for each gene, decreasing with decreasing dose. Using the available annotation of the gene expression changes induced by ER-agonist, our data suggest that a variety of cellular pathways are affected by estrogen exposure. These results indicate that gene expression data are diagnostic of mode of action and, if they are evaluated in the context of traditional toxicological end-points, can be used to elucidate dose-response characteristics.
uses data from: http://identifiers.org/pubmed/15901920

(Assay) PBA: LL_B8x_LD-Gen_75-33
type: Assay
identifier: PBA: LL_B8x_LD-Gen_75-33
has participant: A-AFFY-18

Calb2
type: EnsemblDatabaseReference

(Assay) PBA: EE_B4t_Ctrl-165
type: Assay
identifier: PBA: EE_B4t_Ctrl-165
has participant: A-AFFY-18

Cyp17a1 DOWN in '100 milligram per kilogram per day; genestein' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.48417605762662
p value: 3.48940593298582E-5
refers to: Cyp17a1
refers to: M21208mRNA_s_at
t statistic: -14.991708290128

1373130_at
type: EFO_0005072
part of: A-AFFY-25

(Assay) PBA: 16r_EE_LDResp_M5_1576-171
type: Assay
identifier: PBA: 16r_EE_LDResp_M5_1576-171
has participant: A-AFFY-25

Scarb1
type: EnsemblDatabaseReference

(Factor value) COMPOUND/17a-ethynylestradiol 0.001
type: CHEBI 4903
property type: COMPOUND
property value: 17a-ethynylestradiol 0.001

Analysis of '10 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on 'Affymetrix RG_U34A Array'
type: MicroarrayDifferentialExpressionAnalysis

(Assay) PBA: LM_D6_LD-Gen_75-33
type: Assay
identifier: PBA: LM_D6_LD-Gen_75-33
has participant: A-AFFY-18

(Factor value) COMPOUND/genestein 0.001
type: EFO_0000001
property type: COMPOUND
property value: genestein 0.001

(Assay) PBA: High_G3_LD-Gen_75-33
type: Assay
identifier: PBA: High_G3_LD-Gen_75-33
has participant: A-AFFY-18

1387123_at
type: EFO_0005072
part of: A-AFFY-25

(Assay) PBA: EE_P4t_Ctrl-165
type: Assay
identifier: PBA: EE_P4t_Ctrl-165
has participant: A-AFFY-18

Calb2 DOWN in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: DecreasedDifferentialExpressionRatio
fold change: -1.25760471298728
p value: 0.0456556432921369
refers to: Calb2
refers to: 1387133_at
t statistic: -4.57583623027282

(Assay) PBA: 41_EE_LDResp_H8_1576-171
type: Assay
identifier: PBA: 41_EE_LDResp_H8_1576-171
has participant: A-AFFY-25

(Assay) PBA: Ctrl_A2_LD-BPA_75-12
type: Assay
identifier: PBA: Ctrl_A2_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: Mid_F9_LD-BPA_75-12
type: Assay
identifier: PBA: Mid_F9_LD-BPA_75-12
has participant: A-AFFY-18

Creg1
type: EnsemblDatabaseReference

(Assay) PBA: Ctrl_A3_LD-Gen_75-33
type: Assay
identifier: PBA: Ctrl_A3_LD-Gen_75-33
has participant: A-AFFY-18

(Assay) PBA: 42_EE_LDResp_HH14_1576-171
type: Assay
identifier: PBA: 42_EE_LDResp_HH14_1576-171
has participant: A-AFFY-25

Cyp11a1 DOWN in '10 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.08568141784461
p value: 0.00167174206239866
refers to: Cyp11a1
refers to: J05156_s_at
t statistic: -6.46212291259992

(Assay) PBA: Ctrl_A4_LD-BPA_75-12
type: Assay
identifier: PBA: Ctrl_A4_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: EE_G8t_Ctrl-165
type: Assay
identifier: PBA: EE_G8t_Ctrl-165
has participant: A-AFFY-18

(Assay) PBA: LM_D4_LD-Gen_75-33
type: Assay
identifier: PBA: LM_D4_LD-Gen_75-33
has participant: A-AFFY-18

(Assay) PBA: 10_EE_LDResp_M4_1576-171
type: Assay
identifier: PBA: 10_EE_LDResp_M4_1576-171
has participant: A-AFFY-25

(Assay) PBA: Mid_E9_LD-Gen_75-33
type: Assay
identifier: PBA: Mid_E9_LD-Gen_75-33
has participant: A-AFFY-18

(Assay) PBA: EE_P3t_Ctrl-165
type: Assay
identifier: PBA: EE_P3t_Ctrl-165
has participant: A-AFFY-18

1368468_at
type: EFO_0005072
part of: A-AFFY-25

(Assay) PBA: LL_B4_LD-Gen_75-33
type: Assay
identifier: PBA: LL_B4_LD-Gen_75-33
has participant: A-AFFY-18

(Factor value) COMPOUND/17a-ethynylestradiol 0.5
type: CHEBI 4903
property type: COMPOUND
property value: 17a-ethynylestradiol 0.5

Hbe1 UP in '400 milligram per kilogram per day; bisphenol A' vs 'none' on 'Affymetrix RG_U34A Array'
type: IncreasedDifferentialExpressionRatio
fold change: 1.6657771251432
p value: 0.00423698977534187
refers to: X56326cds_at
refers to: Hbe1
t statistic: 9.05294294062713

(Factor value) COMPOUND/17a-ethynylestradiol 0.01
type: CHEBI 4903
property type: COMPOUND
property value: 17a-ethynylestradiol 0.01

(Assay) PBA: 21_EE_LDResp_L5_1576-171
type: Assay
identifier: PBA: 21_EE_LDResp_L5_1576-171
has participant: A-AFFY-25

Gsta1
type: EnsemblDatabaseReference

(Assay) PBA: 15_EE_LDResp_L4_1576-171
type: Assay
identifier: PBA: 15_EE_LDResp_L4_1576-171
has participant: A-AFFY-25

(Assay) PBA: LM_D2_LD-Gen_75-33
type: Assay
identifier: PBA: LM_D2_LD-Gen_75-33
has participant: A-AFFY-18

Myom2 UP in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: IncreasedDifferentialExpressionRatio
fold change: 1.59587196315737
p value: 1.25648185367566E-4
refers to: 1373130_at
refers to: Myom2
t statistic: 9.50363013106466

Cldn5 UP in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: IncreasedDifferentialExpressionRatio
fold change: 1.17713992050868
p value: 9.73755375630634E-6
refers to: Cldn5
refers to: 1374104_at
t statistic: 12.8620255322085

(Assay) PBA: 30_EE_LDResp_HH10_1576-171
type: Assay
identifier: PBA: 30_EE_LDResp_HH10_1576-171
has participant: A-AFFY-25

(Assay) PBA: High_G1_LD-Gen_75-33
type: Assay
identifier: PBA: High_G1_LD-Gen_75-33
has participant: A-AFFY-18

(Assay) PBA: MH_F1_LD-Gen_75-33
type: Assay
identifier: PBA: MH_F1_LD-Gen_75-33
has participant: A-AFFY-18

Hao2
type: EnsemblDatabaseReference

Scarb1 DOWN in '0.01 milligram per kilogram per day; 17a-ethynylestradiol' vs 'none' on Affymetrix RAE230A Array
type: DecreasedDifferentialExpressionRatio
fold change: -1.14279089428771
p value: 5.09667269471682E-5
refers to: 1386956_at
refers to: Scarb1
t statistic: -10.5648226062502

(Assay) PBA: 14r_EE_LDResp_LL4_1576-171
type: Assay
identifier: PBA: 14r_EE_LDResp_LL4_1576-171
has participant: A-AFFY-25

Cldn5
type: EnsemblDatabaseReference

Svs5 DOWN in '400 milligram per kilogram per day; bisphenol A' vs 'none' on 'Affymetrix RG_U34A Array'
type: DecreasedDifferentialExpressionRatio
fold change: -1.544555954586
p value: 0.0188076524985061
refers to: Svs5
refers to: X01115_at
t statistic: -7.43259304268954

(Assay) PBA: 8_EE_LDResp_LL2_1576-171
type: Assay
identifier: PBA: 8_EE_LDResp_LL2_1576-171
has participant: A-AFFY-25

(Assay) PBA: 11r_EE_LDResp_H3_1576-171
type: Assay
identifier: PBA: 11r_EE_LDResp_H3_1576-171
has participant: A-AFFY-25

(Assay) PBA: EE_G4t_Ctrl-165
type: Assay
identifier: PBA: EE_G4t_Ctrl-165
has participant: A-AFFY-18

(Assay) PBA: Mid_F8_LD-BPA_75-12
type: Assay
identifier: PBA: Mid_F8_LD-BPA_75-12
has participant: A-AFFY-18

(Assay) PBA: High_G2_LD-BPA_75-12
type: Assay
identifier: PBA: High_G2_LD-BPA_75-12
has participant: A-AFFY-18

Star
type: EnsemblDatabaseReference

Svs5
type: EnsemblDatabaseReference

Insl3
type: EnsemblDatabaseReference

(Assay) PBA: 24_EE_LDResp_HH9_1576-171
type: Assay
identifier: PBA: 24_EE_LDResp_HH9_1576-171
has participant: A-AFFY-25

(Assay) PBA: EE_B6t_Ctrl-165
type: Assay
identifier: PBA: EE_B6t_Ctrl-165
has participant: A-AFFY-18