Afp UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Junb UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Cml2 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Krt18 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Soat1 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Vapb DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Ghr DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Asns UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Marco UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Snca DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Hsph1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Lgals2 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Ugt2a3 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
S100a9 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Preb UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Igdcc4 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Trpm4 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Lepr UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Ceacam1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Ngfrap1 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Ldhb UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Fst UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Slc44a2 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Fmo2 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Cmah DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Thrsp DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Eif4g1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Cyp2b10 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Ctla2b UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Pnkd DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Supt16 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Usp2 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Cirbp UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Arid5b DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Nudt7 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Cacna1b UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Peg3 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Prodh DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Ier3 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Slco1b2 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Mmd2 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Calml4 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Gck DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Atp11c DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Dio1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Tiparp UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Cyp2c54 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Ube3a DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Tff3 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Cd5l UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Errfi1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Meg3 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Ocstamp UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Clec2h DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Stfa3 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Gpt DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Upp2 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Tnfaip2 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Ubd UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Apoa4 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Cyp7a1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Malat1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Serpina3k DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Cxcl1 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Car3 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Spink3 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Treml4 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Igf2 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Zfp800 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
N4bp2l1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Cyp2f2 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Dnajc12 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Cockayne syndrome (CS) is a photosensitive, DNA repair disorder associated with progeria caused by a defect in the transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER). Here, complete inactivation of NER in Csbm/m/Xpa-/- mutants causes a phenotype that reliably mimics the human progeroid CS syndrome. Newborn Csbm/m/Xpa-/- mice display attenuated growth, progressive neurological dysfunction, retinal degeneration, cachexia, kyphosis and die before weaning. To investigate whether a disturbance in growth and metabolism could explain the pronounced accelerated organismal deterioration seen in Csbm/m/Xpa-/- mice, we evaluated the liver transcriptome of 15-day old wt, single and double mutant mice (n=4). At this age, the Csbm/m/Xpa-/- pups have not yet become cachectic. Mouse liver transcriptome analysis and several physiological endpoints revealed systemic suppression of the GH/IGF1 somatotroph axis and oxidative metabolism, increased antioxidant responses, hypoglycemia together with hepatic glycogen and fat accumulation. Broad genome-wide parallels between Csbm/m/Xpa-/- and naturally aged mouse liver transcriptomes suggested that these changes are intrinsic to natural aging and the DNA repair-deficient mice. Importantly, wild type (wt) mice exposed to a low dose of chronic genotoxic stress and adult Csbm/m mutant mice recapitulated this response, thereby pointing to a novel link between genome instability and the age-related decline of the somatotroph axis.
Hamp UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Tsc22d3 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Gsta2 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Krt20 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Akr1c18 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Megf9 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Nr3c1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Csad UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Slco2b1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Bex2 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Saa4 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Gprin3 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Keg1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
(Sample) genetic modification/gene knock out
Igf1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Cyp2j5 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Gbp2 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Prpf40a DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Sds DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Esr1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
S100a8 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Pcmtd1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Serpina7 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Cul5 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Serpina6 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Akr1b7 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Car5a DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Fmo3 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Apob DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Cyp4f14 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Mug1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Wif1 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Cyp2c70 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Lin7a DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Hopx DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Analysis of 'Csbm/m/Xpa-/-' vs 'wild type'
Smc6 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Alas1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Rapgef4 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Ppp2r5e DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Slc25a32 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Rock1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Ms4a4b UP in 'Csbm/m/Xpa-/-' vs 'wild type'
(Factor value) GENOTYPE/wild type genotype
Vnn1 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Sucnr1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Gstt2 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Igfals DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Clec4n UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Sdc4 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Hmox1 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
RP23-52N17.1 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Bex1 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Slc22a7 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Mgst2 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Necab1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Ppp1r3b DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Hal DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Slc26a1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Igf2bp2 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
(Sample) specimen with known storage state/frozen specimen
Osbpl3 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Lgals3 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Gpc3 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Inhbb UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Stfa2l1 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Cml1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Xpa DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Coro1a UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Rb1cc1 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Cxcl10 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Slc15a3 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Tfrc DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
Ildr2 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
H2-Aa UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Map2 UP in 'Csbm/m/Xpa-/-' vs 'wild type'
AI314180 DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'
S100g UP in 'Csbm/m/Xpa-/-' vs 'wild type'
2010003K11Rik UP in 'Csbm/m/Xpa-/-' vs 'wild type'
Fn3k DOWN in 'Csbm/m/Xpa-/-' vs 'wild type'