Slc25a4 UP in 'Ercc1 knock-out' vs 'wild type'
Dexi DOWN in 'Ercc1 knock-out' vs 'wild type'
Gm15889 DOWN in 'Ercc1 knock-out' vs 'wild type'
Meg3 UP in 'Ercc1 knock-out' vs 'wild type'
B3galt1 DOWN in 'Ercc1 knock-out' vs 'wild type'
Lpin1 DOWN in 'Ercc1 knock-out' vs 'wild type'
Pctp UP in 'Ercc1 knock-out' vs 'wild type'
Gpr56 UP in 'Ercc1 knock-out' vs 'wild type'
Ubd UP in 'Ercc1 knock-out' vs 'wild type'
Pex11a DOWN in 'Ercc1 knock-out' vs 'wild type'
Hamp UP in 'Ercc1 knock-out' vs 'wild type'
Evl UP in 'Ercc1 knock-out' vs 'wild type'
Ephx1 UP in 'Ercc1 knock-out' vs 'wild type'
Cml2 DOWN in 'Ercc1 knock-out' vs 'wild type'
Hopx DOWN in 'Ercc1 knock-out' vs 'wild type'
Cela3b UP in 'Ercc1 knock-out' vs 'wild type'
Hamp2 UP in 'Ercc1 knock-out' vs 'wild type'
Bex2 UP in 'Ercc1 knock-out' vs 'wild type'
Ankrd33b DOWN in 'Ercc1 knock-out' vs 'wild type'
Sycn UP in 'Ercc1 knock-out' vs 'wild type'
Gpt2 DOWN in 'Ercc1 knock-out' vs 'wild type'
Cyp2c44 UP in 'Ercc1 knock-out' vs 'wild type'
Slc20a1 UP in 'Ercc1 knock-out' vs 'wild type'
Cyp2j5 DOWN in 'Ercc1 knock-out' vs 'wild type'
Gpc3 UP in 'Ercc1 knock-out' vs 'wild type'
Usp2 DOWN in 'Ercc1 knock-out' vs 'wild type'
Nipal1 UP in 'Ercc1 knock-out' vs 'wild type'
Cirbp UP in 'Ercc1 knock-out' vs 'wild type'
Ltf DOWN in 'Ercc1 knock-out' vs 'wild type'
Nln UP in 'Ercc1 knock-out' vs 'wild type'
Lepr UP in 'Ercc1 knock-out' vs 'wild type'
Unc119 UP in 'Ercc1 knock-out' vs 'wild type'
Igf2 UP in 'Ercc1 knock-out' vs 'wild type'
Ppp1r3b DOWN in 'Ercc1 knock-out' vs 'wild type'
Cpb1 UP in 'Ercc1 knock-out' vs 'wild type'
Slco2b1 DOWN in 'Ercc1 knock-out' vs 'wild type'
Fmo3 DOWN in 'Ercc1 knock-out' vs 'wild type'
Apoa4 UP in 'Ercc1 knock-out' vs 'wild type'
Col4a3 DOWN in 'Ercc1 knock-out' vs 'wild type'
Aqp4 UP in 'Ercc1 knock-out' vs 'wild type'
Ctrb1 UP in 'Ercc1 knock-out' vs 'wild type'
Gck DOWN in 'Ercc1 knock-out' vs 'wild type'
Serpina3k DOWN in 'Ercc1 knock-out' vs 'wild type'
Ppbp DOWN in 'Ercc1 knock-out' vs 'wild type'
Rdh16 UP in 'Ercc1 knock-out' vs 'wild type'
Bex1 UP in 'Ercc1 knock-out' vs 'wild type'
Olig1 UP in 'Ercc1 knock-out' vs 'wild type'
Nfe2l2 UP in 'Ercc1 knock-out' vs 'wild type'
Cpa2 UP in 'Ercc1 knock-out' vs 'wild type'
Fabp7 UP in 'Ercc1 knock-out' vs 'wild type'
Pnliprp1 UP in 'Ercc1 knock-out' vs 'wild type'
Id4 UP in 'Ercc1 knock-out' vs 'wild type'
Tnfaip2 UP in 'Ercc1 knock-out' vs 'wild type'
Pnliprp2 UP in 'Ercc1 knock-out' vs 'wild type'
Enpp3 UP in 'Ercc1 knock-out' vs 'wild type'
Asns UP in 'Ercc1 knock-out' vs 'wild type'
Zg16 UP in 'Ercc1 knock-out' vs 'wild type'
Ehhadh UP in 'Ercc1 knock-out' vs 'wild type'
Apon DOWN in 'Ercc1 knock-out' vs 'wild type'
Osgin1 UP in 'Ercc1 knock-out' vs 'wild type'
Mt1 DOWN in 'Ercc1 knock-out' vs 'wild type'
Spink3 UP in 'Ercc1 knock-out' vs 'wild type'
Mgst2 UP in 'Ercc1 knock-out' vs 'wild type'
Slc22a7 DOWN in 'Ercc1 knock-out' vs 'wild type'
Gstt2 UP in 'Ercc1 knock-out' vs 'wild type'
Id1 UP in 'Ercc1 knock-out' vs 'wild type'
Afp UP in 'Ercc1 knock-out' vs 'wild type'
Marco UP in 'Ercc1 knock-out' vs 'wild type'
Gsta2 UP in 'Ercc1 knock-out' vs 'wild type'
Inhbb UP in 'Ercc1 knock-out' vs 'wild type'
Reg1 UP in 'Ercc1 knock-out' vs 'wild type'
Cel UP in 'Ercc1 knock-out' vs 'wild type'
Hsd17b11 UP in 'Ercc1 knock-out' vs 'wild type'
Trpm4 UP in 'Ercc1 knock-out' vs 'wild type'
Ngfrap1 UP in 'Ercc1 knock-out' vs 'wild type'
Grb10 UP in 'Ercc1 knock-out' vs 'wild type'
Ngp DOWN in 'Ercc1 knock-out' vs 'wild type'
Mug1 DOWN in 'Ercc1 knock-out' vs 'wild type'
Ctrl UP in 'Ercc1 knock-out' vs 'wild type'
Prodh DOWN in 'Ercc1 knock-out' vs 'wild type'
2210010C04Rik UP in 'Ercc1 knock-out' vs 'wild type'
Chic1 DOWN in 'Ercc1 knock-out' vs 'wild type'
Dleu2 DOWN in 'Ercc1 knock-out' vs 'wild type'
Scd1 UP in 'Ercc1 knock-out' vs 'wild type'
Mt2 DOWN in 'Ercc1 knock-out' vs 'wild type'
Prss2 UP in 'Ercc1 knock-out' vs 'wild type'
Vldlr UP in 'Ercc1 knock-out' vs 'wild type'
8430408G22Rik UP in 'Ercc1 knock-out' vs 'wild type'
Arhgef26 DOWN in 'Ercc1 knock-out' vs 'wild type'
Arrdc4 UP in 'Ercc1 knock-out' vs 'wild type'
Ccng1 UP in 'Ercc1 knock-out' vs 'wild type'
Sesn3 UP in 'Ercc1 knock-out' vs 'wild type'
Ank2 UP in 'Ercc1 knock-out' vs 'wild type'
Uap1 DOWN in 'Ercc1 knock-out' vs 'wild type'
RP23-52N17.1 UP in 'Ercc1 knock-out' vs 'wild type'
Chil3 DOWN in 'Ercc1 knock-out' vs 'wild type'
Btg2 UP in 'Ercc1 knock-out' vs 'wild type'
Cacna1b UP in 'Ercc1 knock-out' vs 'wild type'
(Factor value) GENOTYPE/wild type genotype
Sntg2 DOWN in 'Ercc1 knock-out' vs 'wild type'
S100a8 DOWN in 'Ercc1 knock-out' vs 'wild type'
Vnn1 UP in 'Ercc1 knock-out' vs 'wild type'
Ccrn4l DOWN in 'Ercc1 knock-out' vs 'wild type'
Saa4 DOWN in 'Ercc1 knock-out' vs 'wild type'
Klk1 UP in 'Ercc1 knock-out' vs 'wild type'
Ldhb UP in 'Ercc1 knock-out' vs 'wild type'
Gria3 UP in 'Ercc1 knock-out' vs 'wild type'
Psrc1 UP in 'Ercc1 knock-out' vs 'wild type'
Rnase1 UP in 'Ercc1 knock-out' vs 'wild type'
Abcb1a UP in 'Ercc1 knock-out' vs 'wild type'
Cela2a UP in 'Ercc1 knock-out' vs 'wild type'
Peg3 UP in 'Ercc1 knock-out' vs 'wild type'
Ces2e UP in 'Ercc1 knock-out' vs 'wild type'
(Sample) specimen with known storage state/frozen specimen
Enc1 UP in 'Ercc1 knock-out' vs 'wild type'
Orm1 DOWN in 'Ercc1 knock-out' vs 'wild type'
Neat1 UP in 'Ercc1 knock-out' vs 'wild type'
Adck4 UP in 'Ercc1 knock-out' vs 'wild type'
Elovl3 DOWN in 'Ercc1 knock-out' vs 'wild type'
Lgals1 UP in 'Ercc1 knock-out' vs 'wild type'
Cyp1a2 DOWN in 'Ercc1 knock-out' vs 'wild type'
Fkrp UP in 'Ercc1 knock-out' vs 'wild type'
Thrsp DOWN in 'Ercc1 knock-out' vs 'wild type'
Gpcpd1 UP in 'Ercc1 knock-out' vs 'wild type'
Zbtb16 DOWN in 'Ercc1 knock-out' vs 'wild type'
Cyp2c54 UP in 'Ercc1 knock-out' vs 'wild type'
S100a9 DOWN in 'Ercc1 knock-out' vs 'wild type'
Cyp4f14 DOWN in 'Ercc1 knock-out' vs 'wild type'
Igdcc4 UP in 'Ercc1 knock-out' vs 'wild type'
Camp DOWN in 'Ercc1 knock-out' vs 'wild type'
Tmem86a UP in 'Ercc1 knock-out' vs 'wild type'
Krt23 UP in 'Ercc1 knock-out' vs 'wild type'
Wif1 UP in 'Ercc1 knock-out' vs 'wild type'
Clps UP in 'Ercc1 knock-out' vs 'wild type'
Cyp2c70 DOWN in 'Ercc1 knock-out' vs 'wild type'
To investigate the cause of the premature aging features in the Ercc1-/- mouse, we compared the entire transcriptome of the Ercc1-/- mouse liver to that of wildtype littermates at the age of 15 days, when the Ercc1-/- mice reached their maximal weight and had symptoms of progeria, yet overall pathology was still limited. The liver was selected because the tissue showed several well-defined histological changes associated with aging (polyploidy and intranuclear inclusions) as well as evidence that it is responding to endogenous genotoxic stress (stabilized p53).
Akr1c18 UP in 'Ercc1 knock-out' vs 'wild type'
Tsc22d3 DOWN in 'Ercc1 knock-out' vs 'wild type'
Ildr2 DOWN in 'Ercc1 knock-out' vs 'wild type'
Calml4 UP in 'Ercc1 knock-out' vs 'wild type'
Arxes2 UP in 'Ercc1 knock-out' vs 'wild type'
Cpa1 UP in 'Ercc1 knock-out' vs 'wild type'
Akr1b7 UP in 'Ercc1 knock-out' vs 'wild type'
(Sample) genetic modification/gene knock out
Abcc3 UP in 'Ercc1 knock-out' vs 'wild type'
Dio1 DOWN in 'Ercc1 knock-out' vs 'wild type'
Ppp1r3g UP in 'Ercc1 knock-out' vs 'wild type'
Analysis of 'Ercc1 knock-out' vs 'wild type'
1100001G20Rik DOWN in 'Ercc1 knock-out' vs 'wild type'
Fam107a DOWN in 'Ercc1 knock-out' vs 'wild type'
Txnip UP in 'Ercc1 knock-out' vs 'wild type'
Krt18 UP in 'Ercc1 knock-out' vs 'wild type'
Itih5 UP in 'Ercc1 knock-out' vs 'wild type'