227062_at
type: EFO_0005072
part of: A-AFFY-44

Analysis of 'type 2 diabetes probands' vs 'healthy unrelated individuals'
type: MicroarrayDifferentialExpressionAnalysis

NEAT1
type: EnsemblDatabaseReference

RARA UP in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: IncreasedDifferentialExpressionRatio
fold change: 1.3356933109153
p value: 0.00783670557893357
refers to: RARA
refers to: 1565358_at
t statistic: 5.19947590215684

(Sample) family relationship/unrelated
type: EFO_0000001
property type: family relationship
property value: unrelated

(Factor value) FAMILY_RELATIONSHIP/proband
type: EFO_0000001
property type: FAMILY_RELATIONSHIP
property value: proband

C1orf168 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1820103749583
p value: 0.0213167395071637
refers to: C1orf168
refers to: 238625_at
t statistic: -4.146596055113

RGS5 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.05461429438903
p value: 0.0066311817638501
refers to: 1555725_a_at
refers to: RGS5
t statistic: -5.40702402599132

KIF1B
type: EnsemblDatabaseReference

C1orf168
type: EnsemblDatabaseReference

C1orf168
type: EnsemblDatabaseReference

(Assay) exp 3-16
type: Assay
identifier: exp 3-16
has participant: A-AFFY-44

203395_s_at
type: EFO_0005072
part of: A-AFFY-44

(Sample) organism part/skeletal muscle
type: CL_0000188
property type: organism part
property value: skeletal muscle

(Assay) exp 1-3
type: Assay
identifier: exp 1-3
has participant: A-AFFY-44

KIF1B
type: EnsemblDatabaseReference

NEAT1 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.09084526423995
p value: 0.0156805630750183
refers to: NEAT1
refers to: 238320_at
t statistic: -4.46378991711896

TTN
type: EnsemblDatabaseReference

TTN
type: EnsemblDatabaseReference

(Assay) exp 1-4
type: Assay
identifier: exp 1-4
has participant: A-AFFY-44

(Assay) exp 3-1
type: Assay
identifier: exp 3-1
has participant: A-AFFY-44

238320_at
type: EFO_0005072
part of: A-AFFY-44

203394_s_at
type: EFO_0005072
part of: A-AFFY-44

Analysis of 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: MicroarrayDifferentialExpressionAnalysis

(Sample) family relationship/proband
type: EFO_0000001
property type: family relationship
property value: proband

TTN DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.52225442888158
p value: 0.00124923516949184
refers to: TTN
refers to: 1557994_at
t statistic: -7.5498950773446

(Assay) exp 2-3
type: Assay
identifier: exp 2-3
has participant: A-AFFY-44

A-AFFY-44
type: EFO_0000269

(Assay) exp 3-14
type: Assay
identifier: exp 3-14
has participant: A-AFFY-44

(Sample) family relationship/first degree relative
type: EFO_0000001
property type: family relationship
property value: first degree relative

(Assay) exp 2-2
type: Assay
identifier: exp 2-2
has participant: A-AFFY-44

(Assay) exp 2-7
type: Assay
identifier: exp 2-7
has participant: A-AFFY-44

NEAT1 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.13226270056411
p value: 0.00891533655565947
refers to: NEAT1
refers to: 227062_at
t statistic: -5.02880617893952

HES1 DOWN in 'type 2 diabetes probands' vs 'healthy unrelated individuals'
type: DecreasedDifferentialExpressionRatio
fold change: -1.23988950354657
p value: 0.00214932680652967
refers to: HES1
refers to: 203395_s_at
t statistic: -7.01363714741849

209234_at
type: EFO_0005072
part of: A-AFFY-44

202934_at
type: EFO_0005072
part of: A-AFFY-44

1557994_at
type: EFO_0005072
part of: A-AFFY-44

(Factor value) FAMILY_RELATIONSHIP/first degree relative
type: EFO_0000001
property type: FAMILY_RELATIONSHIP
property value: first degree relative

(Assay) exp 3-12
type: Assay
identifier: exp 3-12
has participant: A-AFFY-44

NEB DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.03364587632755
p value: 0.00466910321019509
refers to: 215368_at
refers to: NEB
t statistic: -5.78323916585365

(Sample) organism/Homo sapiens
type: Homo sapiens
property type: organism
property value: Homo sapiens

PFKFB3
type: EnsemblDatabaseReference

PFKFB3
type: EnsemblDatabaseReference

(Assay) exp 1-5
type: Assay
identifier: exp 1-5
has participant: A-AFFY-44

(Assay) exp 2-13
type: Assay
identifier: exp 2-13
has participant: A-AFFY-44

TTN DOWN in 'type 2 diabetes probands' vs 'healthy unrelated individuals'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01283189438703
p value: 0.0314572246183581
refers to: TTN
refers to: 241791_at
t statistic: -4.88353770245918

HES1
type: EnsemblDatabaseReference

(Assay) exp 2-9
type: Assay
identifier: exp 2-9
has participant: A-AFFY-44

HES1
type: EnsemblDatabaseReference

(Assay) exp 3-8
type: Assay
identifier: exp 3-8
has participant: A-AFFY-44

(Assay) exp 1-2
type: Assay
identifier: exp 1-2
has participant: A-AFFY-44

1555725_a_at
type: EFO_0005072
part of: A-AFFY-44

PFKFB3 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.20760891118014
p value: 0.0426335326180878
refers to: 202464_s_at
refers to: PFKFB3
t statistic: -3.46872504964329

(Assay) exp 2-12
type: Assay
identifier: exp 2-12
has participant: A-AFFY-44

NEAT1 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.14741183541487
p value: 0.0102457670297236
refers to: 224566_at
refers to: NEAT1
t statistic: -4.93409308312966

(Assay) exp 3-5
type: Assay
identifier: exp 3-5
has participant: A-AFFY-44

TTN DOWN in 'type 2 diabetes probands' vs 'healthy unrelated individuals'
type: DecreasedDifferentialExpressionRatio
fold change: -1.16938713782032
p value: 0.0157781024962535
refers to: TTN
refers to: 1557994_at
t statistic: -5.58225516218035

Homo sapiens
type: OBI_0100026

(Assay) exp 2-11
type: Assay
identifier: exp 2-11
has participant: A-AFFY-44

(Sample) disease/normal
type: EFO_0000761
property type: disease
property value: normal

202464_s_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) exp 3-9
type: Assay
identifier: exp 3-9
has participant: A-AFFY-44

(Assay) exp 3-15
type: Assay
identifier: exp 3-15
has participant: A-AFFY-44

HES1 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1509817677844
p value: 0.0050155868656718
refers to: HES1
refers to: 203395_s_at
t statistic: -5.66250090854975

(Assay) exp 3-10
type: Assay
identifier: exp 3-10
has participant: A-AFFY-44

TTN DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.33660796250578
p value: 0.00586568868312907
refers to: 241791_at
refers to: TTN
t statistic: -5.52853862235158

215368_at
type: EFO_0005072
part of: A-AFFY-44

CTNNA3
type: EnsemblDatabaseReference

CTNNA3
type: EnsemblDatabaseReference

(Assay) exp 3-3
type: Assay
identifier: exp 3-3
has participant: A-AFFY-44

CTNNA3 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00161620548757
p value: 0.00669350922467766
refers to: CTNNA3
refers to: 236576_at
t statistic: -5.37094654082287

HK2
type: EnsemblDatabaseReference

HK2
type: EnsemblDatabaseReference

(Assay) exp 3-11
type: Assay
identifier: exp 3-11
has participant: A-AFFY-44

(Sample) disease/type II diabetes mellitus
type: EFO_0000001
property type: disease
property value: type II diabetes mellitus

(Assay) exp 2-8
type: Assay
identifier: exp 2-8
has participant: A-AFFY-44

RGS5
type: EnsemblDatabaseReference

RGS5
type: EnsemblDatabaseReference

238625_at
type: EFO_0005072
part of: A-AFFY-44

HES1 DOWN in 'type 2 diabetes probands' vs 'healthy unrelated individuals'
type: DecreasedDifferentialExpressionRatio
fold change: -1.14608202377201
p value: 0.0122340457752838
refers to: HES1
refers to: 203394_s_at
t statistic: -5.84966145836455

KIF1B DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0324040323352
p value: 0.0174245601195328
refers to: KIF1B
refers to: 209234_at
t statistic: -4.34285979762392

(Assay) exp 3-13
type: Assay
identifier: exp 3-13
has participant: A-AFFY-44

(Assay) exp 2-1
type: Assay
identifier: exp 2-1
has participant: A-AFFY-44

(Assay) exp 2-5
type: Assay
identifier: exp 2-5
has participant: A-AFFY-44

(Sample) ethnic group/Danish Caucasian
type: EFO_0000001
property type: ethnic group
property value: Danish Caucasian

(Assay) exp 2-4
type: Assay
identifier: exp 2-4
has participant: A-AFFY-44

NEB
type: EnsemblDatabaseReference

(Assay) exp 1-1
type: Assay
identifier: exp 1-1
has participant: A-AFFY-44

NEB
type: EnsemblDatabaseReference

NEAT1
type: EnsemblDatabaseReference

(Assay) exp 2-10
type: Assay
identifier: exp 2-10
has participant: A-AFFY-44

1565358_at
type: EFO_0005072
part of: A-AFFY-44

236576_at
type: EFO_0005072
part of: A-AFFY-44

224566_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) exp 2-6
type: Assay
identifier: exp 2-6
has participant: A-AFFY-44

(Assay) exp 3-2
type: Assay
identifier: exp 3-2
has participant: A-AFFY-44

(Factor value) DISEASE/normal
type: EFO_0000761
property type: DISEASE
property value: normal

HK2 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
type: DecreasedDifferentialExpressionRatio
fold change: -1.11950880091441
p value: 0.0277681411218445
refers to: 202934_at
refers to: HK2
t statistic: -3.86374448874873

(Sample) sex/male
type: EFO_0001266
property type: sex
property value: male

(Factor value) FAMILY_RELATIONSHIP/unrelated
type: EFO_0000001
property type: FAMILY_RELATIONSHIP
property value: unrelated

241791_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) exp 2-15
type: Assay
identifier: exp 2-15
has participant: A-AFFY-44

(Assay) exp 3-4
type: Assay
identifier: exp 3-4
has participant: A-AFFY-44

(Assay) exp 3-6
type: Assay
identifier: exp 3-6
has participant: A-AFFY-44

(Assay) exp 2-14
type: Assay
identifier: exp 2-14
has participant: A-AFFY-44

RARA
type: EnsemblDatabaseReference

(Factor value) DISEASE/type II diabetes mellitus
type: EFO_0000001
property type: DISEASE
property value: type II diabetes mellitus

RARA
type: EnsemblDatabaseReference

E-MEXP-2559
type: microarray 1colour mrna differential
RO_0002162: Homo sapiens
description: We determined the expression profiles in skeletal muscle from people with type 2 diabetes, first degree relatives, and healthy control individuals by microarray experiments. All subjects were Caucasian males and biopsies were taken after a controlled metabolic period of a two hour hyperinsulinemic euglycemic clamp. Our results show for the first time that insulin signaling is significantly downregulated in people with type 2 diabetes, whereas it is significantly upregulated in first degree relatives. Furthermore, we identify several new genes in skeletal muscle from first degree relatives that have an altered gene expression compared to healthy controls.
uses data from: http://identifiers.org/pubmed/19668377