Analysis of 'type 2 diabetes probands' vs 'healthy unrelated individuals'
RARA UP in 'type 2 diabetes probands' vs 'healthy first degree relatives'
(Factor value) FAMILY_RELATIONSHIP/proband
C1orf168 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
RGS5 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
NEAT1 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
Analysis of 'type 2 diabetes probands' vs 'healthy first degree relatives'
TTN DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
(Sample) family relationship/first degree relative
HES1 DOWN in 'type 2 diabetes probands' vs 'healthy unrelated individuals'
(Factor value) FAMILY_RELATIONSHIP/first degree relative
NEB DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
TTN DOWN in 'type 2 diabetes probands' vs 'healthy unrelated individuals'
PFKFB3 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
HES1 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
CTNNA3 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
(Sample) disease/type II diabetes mellitus
KIF1B DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
HK2 DOWN in 'type 2 diabetes probands' vs 'healthy first degree relatives'
(Factor value) FAMILY_RELATIONSHIP/unrelated
(Factor value) DISEASE/type II diabetes mellitus
We determined the expression profiles in skeletal muscle from people with type 2 diabetes, first degree relatives, and healthy control individuals by microarray experiments. All subjects were Caucasian males and biopsies were taken after a controlled metabolic period of a two hour hyperinsulinemic euglycemic clamp. Our results show for the first time that insulin signaling is significantly downregulated in people with type 2 diabetes, whereas it is significantly upregulated in first degree relatives. Furthermore, we identify several new genes in skeletal muscle from first degree relatives that have an altered gene expression compared to healthy controls.