SLC25A36 UP in 'male' vs 'female' in 'Parkinson's disease'
REEP1 UP in 'male' vs 'female' in 'Parkinson's disease'
TMEM255A UP in 'male' vs 'female' in 'Parkinson's disease'
VWA5A UP in 'male' vs 'female' in 'Parkinson's disease'
(Sample) clinical history/cells derived from a 81-year-old donor
(Sample) clinical history/cells derived from a 63-year-old donor
KCNJ6 UP in 'male' vs 'female' in 'Parkinson's disease'
Analysis of 'male' vs 'female' in 'normal'
PGM2L1 UP in 'male' vs 'female' in 'Parkinson's disease'
SLC18A2 UP in 'male' vs 'female' in 'Parkinson's disease'
PCDH8 UP in 'male' vs 'female' in 'Parkinson's disease'
COL11A1 UP in 'male' vs 'female' in 'Parkinson's disease'
KLHL1 UP in 'male' vs 'female' in 'Parkinson's disease'
(Sample) clinical history/cells derived from a 78-year-old donor
FASTKD1 UP in 'male' vs 'female' in 'Parkinson's disease'
(Sample) clinical history/cells derived from a 94-year-old donor
TMEFF2 UP in 'male' vs 'female' in 'Parkinson's disease'
TXLNGY UP in 'male' vs 'female' in 'normal'
(Sample) cell type/melanized domamine neuron
FAM120A UP in 'male' vs 'female' in 'normal'
(Sample) clinical history/cells derived from a 89-year-old donor
CELF2 UP in 'male' vs 'female' in 'normal'
TCF4 DOWN in 'male' vs 'female' in 'Parkinson's disease'
(Sample) clinical history/cells derived from a 69-year-old donor
RPS4Y1 UP in 'male' vs 'female' in 'normal'
XIST DOWN in 'male' vs 'female' in 'Parkinson's disease'
DDX3Y UP in 'male' vs 'female' in 'normal'
STMN2 UP in 'male' vs 'female' in 'Parkinson's disease'
VAV3 UP in 'male' vs 'female' in 'Parkinson's disease'
(Sample) clinical history/cells derived from a 84-year-old donor
RGS2 UP in 'male' vs 'female' in 'Parkinson's disease'
ZNF385D UP in 'male' vs 'female' in 'Parkinson's disease'
EIF1AY UP in 'male' vs 'female' in 'normal'
KDM5D UP in 'male' vs 'female' in 'normal'
(Sample) clinical history/cells derived from a 62-year-old donor
RPS4Y1 UP in 'male' vs 'female' in 'Parkinson's disease'
(Sample) clinical history/cells derived from a 61-year-old donor
PEG10 UP in 'male' vs 'female' in 'Parkinson's disease'
NOV UP in 'male' vs 'female' in 'Parkinson's disease'
(Sample) specimen with known storage state/frozen specimen
XIST DOWN in 'male' vs 'female' in 'normal'
(Sample) clinical history/cells derived from a 68-year-old donor
(Sample) clinical history/cells derived from a 74-year-old donor
TOX3 UP in 'male' vs 'female' in 'Parkinson's disease'
EBF3 UP in 'male' vs 'female' in 'Parkinson's disease'
We used 500 melanized dopamine neurons isolated from post-mortem human substantia nigra pars compacta of each sample with laser capture microdissection. Total RNA was extracted with Arcturus PicoPure RNA extraction kit and amplified two times with Arcturus RiboAmp RNA amplification kit. the samples were then sent to the Partners Center for Genetics and Genomics (HPCGG.org) for labeling, hybridization and scanning according to standard Affymetrix protocols. Samples from a total of 16 human brains, 8 PDs (4 male and 4 female) and 8 controls (4 male and 4 female) were studied. These were selected from available material after screening total RNA extracted from a small region of the SN for integrity of 18S and 28S species using an Agilent bioanalyzer. We also matched the cases for age and post mortem interval (PMI) (PD Female age, 75 ÃÂ± 4.4, PMI, 20.5 ÃÂ± 2.5; PD Male age 77 ÃÂ± 6.3, PMI 13.85 ÃÂ± 1.7; Con Female age 68 ÃÂ± 3.3, PMI 21.8 ÃÂ± 0.8; Con Male age 70.2 ÃÂ± 6.3, PMI 18.11 ÃÂ± 3.6). Vital Statistics of the cases used in this study. PD= Parkinson disease, C= Control, F=Female, M=Male: Case Age Sex PMI Cel file Pdf1 81 F 17 459F cf1 61 f <24 515H Pdf2 84 F 24.08 515K cf2 n/a f >48 515I Pdf3 69 F <24 515J cf3 74 f 23.00 459D Pdf4 66 F <24 515F cf4 69 f 20.70 459A pdm1 68 m 17.16 515E Cm1 67 m 22.33 459C pdm2 67 m 14.5 515D Cm2 63 m 21.50 459B pdm3 94 m 9.25 515G Cm3 62 m 21.20 515L pdm4 78 m 14.50 515B Cm4 89 m 7.42 515C
Analysis of 'male' vs 'female' in 'Parkinson's disease'
NLK UP in 'male' vs 'female' in 'Parkinson's disease'
(Sample) clinical history/cells derived from a 66-year-old donor
DDX3Y UP in 'male' vs 'female' in 'Parkinson's disease'
GPRC5C DOWN in 'male' vs 'female' in 'normal'
SV2C UP in 'male' vs 'female' in 'Parkinson's disease'
(Sample) clinical history/cells derived from a donor of unknown age
cells derived from a donor of unknown age
IL13RA2 UP in 'male' vs 'female' in 'Parkinson's disease'
ERC2 UP in 'male' vs 'female' in 'Parkinson's disease'
TMEM178B UP in 'male' vs 'female' in 'Parkinson's disease'
PAPPA UP in 'male' vs 'female' in 'Parkinson's disease'
LINC00261 UP in 'male' vs 'female' in 'Parkinson's disease'
(Factor value) DISEASE/Parkinson's disease
LPGAT1 UP in 'male' vs 'female' in 'Parkinson's disease'
(Sample) clinical history/cells derived from a 67-year-old donor
SDC2 UP in 'male' vs 'female' in 'Parkinson's disease'
RP11-731J8.2 UP in 'male' vs 'female' in 'Parkinson's disease'