Mtmr7
type: EnsemblDatabaseReference

Gm21967
type: EnsemblDatabaseReference

Myef2 UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.03669284502875
p value: 0.0127555888908942
refers to: 1425349_a_at
refers to: Myef2
t statistic: 6.5826891968489

(Sample) specimen with known storage state/frozen specimen
type: EFO_0000001
property type: specimen with known storage state
property value: frozen specimen

(Sample) genotype/wild type genotype
type: EFO_0000001
property type: genotype
property value: wild type genotype

Pttg1 UP in 'TBP105Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.96715599739517
p value: 0.0189451102603134
refers to: Pttg1
refers to: 1424105_a_at
t statistic: 5.60668988746227

(Assay) TBP-105Qb
type: Assay
has participant: A-AFFY-45

Analysis of 'TBP105Q' vs 'wild type'
type: MicroarrayDifferentialExpressionAnalysis

1452318_a_at
type: EFO_0005072
part of: A-AFFY-45

1426607_at
type: EFO_0005072
part of: A-AFFY-45

Hp1bp3 DOWN in 'TBP13Q' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.17411712037702
p value: 0.0027763201309237
refers to: Hp1bp3
refers to: 1439845_at
t statistic: -9.69645812943251

Cap1 UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.84074678386133
p value: 0.046753461763818
refers to: 1417461_at
refers to: Cap1
t statistic: 4.27944920944764

(Factor value) GENOTYPE/wild type genotype
type: EFO_0000001
property type: GENOTYPE
property value: wild type genotype

Pttg1
type: EnsemblDatabaseReference

Soga3 DOWN in 'TBP105Q' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -2.1948963300343
p value: 3.18355029180623E-4
refers to: Soga3
refers to: 1429628_at
t statistic: -14.2633501293223

Cap1
type: EnsemblDatabaseReference

Gnb1
type: EnsemblDatabaseReference

1447831_s_at
type: EFO_0005072
part of: A-AFFY-45

Car8 UP in 'TBP105Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 2.03482516785094
p value: 9.23529576751025E-4
refers to: 1457904_at
refers to: Car8
t statistic: 11.459323993858

(Sample) disease/spinocerebellar ataxia type 17
type: EFO_0000001
property type: disease
property value: spinocerebellar ataxia type 17

Cap1
type: EnsemblDatabaseReference

1429628_at
type: EFO_0005072
part of: A-AFFY-45

Gnb1
type: EnsemblDatabaseReference

1418701_at
type: EFO_0005072
part of: A-AFFY-45

F2r UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.12167001846834
p value: 0.0027107195478829
refers to: F2r
refers to: 1437308_s_at
t statistic: 9.81492796413223

1423150_at
type: EFO_0005072
part of: A-AFFY-45

1425349_a_at
type: EFO_0005072
part of: A-AFFY-45

Pdk4
type: EnsemblDatabaseReference

1425336_x_at
type: EFO_0005072
part of: A-AFFY-45

Hspa1b UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.23099775673877
p value: 0.0495258553328525
refers to: Hspa1b
refers to: 1452318_a_at
t statistic: 4.1773587725346

Tcte1 DOWN in 'TBP13Q' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.20266020160427
p value: 0.0193335698916908
refers to: Tcte1
refers to: 1419344_at
t statistic: -5.72920813107647

Slc1a2 UP in 'TBP105Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.26800513574892
p value: 0.0060611244380703
refers to: Slc1a2
refers to: 1439940_at
t statistic: 7.7112667153282

F2r
type: EnsemblDatabaseReference

(Assay) WTa
type: Assay
has participant: A-AFFY-45

Gm21967 UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.02441734364204
p value: 0.0234975562774723
refers to: Gm21967
refers to: 1426607_at
t statistic: 5.36973996419287

Tcte1
type: EnsemblDatabaseReference

1424105_a_at
type: EFO_0005072
part of: A-AFFY-45

Kif5c
type: EnsemblDatabaseReference

Myef2
type: EnsemblDatabaseReference

Gnb1 UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.94488010034303
p value: 0.0444817393936496
refers to: Gnb1
refers to: 1417432_a_at
t statistic: 4.35648701217292

(Sample) age/8
type: EFO_0000001
property type: age
property value: 8

Car8 UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 2.08294873533033
p value: 0.00145865378599358
refers to: 1457904_at
refers to: Car8
t statistic: 12.2290577331755

(Sample) organism/Mus musculus
type: Mus musculus
property type: organism
property value: Mus musculus

Zfp871
type: EnsemblDatabaseReference

Mir1931
type: EnsemblDatabaseReference

Mtmr7 DOWN in 'TBP13Q' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.46897156549788
p value: 0.00227673008302949
refers to: Mtmr7
refers to: 1447831_s_at
t statistic: -10.6159314142953

1439940_at
type: EFO_0005072
part of: A-AFFY-45

Mir1931 DOWN in 'TBP13Q' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01277106082958
p value: 0.00145865378599358
refers to: 1446130_at
refers to: Mir1931
t statistic: -11.7732885518911

Comt
type: EnsemblDatabaseReference

1422945_a_at
type: EFO_0005072
part of: A-AFFY-45

Zfp871 UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.94792818304312
p value: 0.00145865378599358
refers to: Zfp871
refers to: 1435163_at
t statistic: 11.632119906161

(Assay) WTb
type: Assay
has participant: A-AFFY-45

Comt
type: EnsemblDatabaseReference

Car8
type: EnsemblDatabaseReference

(Assay) TBP-13Qc
type: Assay
has participant: A-AFFY-45

(Assay) TBP-105Qc
type: Assay
has participant: A-AFFY-45

Mus musculus
type: OBI_0100026

Efhd2
type: EnsemblDatabaseReference

1417273_at
type: EFO_0005072
part of: A-AFFY-45

(Sample) genotype/TBP13Q
type: EFO_0000001
property type: genotype
property value: TBP13Q

Car8
type: EnsemblDatabaseReference

(Assay) TBP-13Qb
type: Assay
has participant: A-AFFY-45

Efhd2
type: EnsemblDatabaseReference

H2-K1
type: EnsemblDatabaseReference

Scg5
type: EnsemblDatabaseReference

(Factor value) GENOTYPE/TBP13Q
type: EFO_0000001
property type: GENOTYPE
property value: TBP13Q

(Sample) organism part/cerebellum
type: UBERON_0002037
property type: organism part
property value: cerebellum

Pvrl3
type: EnsemblDatabaseReference

F2r
type: EnsemblDatabaseReference

Scg5 UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.08487756274847
p value: 0.00656898726924039
refers to: 1423150_at
refers to: Scg5
t statistic: 8.03903074838473

Tcte1
type: EnsemblDatabaseReference

Hp1bp3
type: EnsemblDatabaseReference

(Assay) TBP-13Qa
type: Assay
has participant: A-AFFY-45

(Sample) developmental stage/adult
type: EFO_0001272
property type: developmental stage
property value: adult

Myef2
type: EnsemblDatabaseReference

1437478_s_at
type: EFO_0005072
part of: A-AFFY-45

Zfp871
type: EnsemblDatabaseReference

Mir1931
type: EnsemblDatabaseReference

(Assay) WTc
type: Assay
has participant: A-AFFY-45

Hp1bp3
type: EnsemblDatabaseReference

H2-K1 UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.02100073354311
p value: 0.0137072084330737
refers to: H2-K1
refers to: 1425336_x_at
t statistic: 6.33749327464013

Slc1a2
type: EnsemblDatabaseReference

Soga3
type: EnsemblDatabaseReference

(Sample) disease/normal
type: EFO_0000761
property type: disease
property value: normal

Hspa1b
type: EnsemblDatabaseReference

1437308_s_at
type: EFO_0005072
part of: A-AFFY-45

Mtmr7
type: EnsemblDatabaseReference

Comt UP in 'TBP105Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.23629696459788
p value: 0.0244473358336118
refers to: Comt
refers to: 1418701_at
t statistic: 5.2108228317985

1417461_at
type: EFO_0005072
part of: A-AFFY-45

Gm21967
type: EnsemblDatabaseReference

1448673_at
type: EFO_0005072
part of: A-AFFY-45

Pvrl3 UP in 'TBP105Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.28172694430292
p value: 0.00318201606287344
refers to: 1448673_at
refers to: Pvrl3
t statistic: 8.99085254676377

Soga3 DOWN in 'TBP13Q' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -2.0480583575264
p value: 0.00104739475691184
refers to: 1429628_at
refers to: Soga3
t statistic: -13.5600129957914

1446130_at
type: EFO_0005072
part of: A-AFFY-45

H2-K1
type: EnsemblDatabaseReference

Scg5
type: EnsemblDatabaseReference

1457904_at
type: EFO_0005072
part of: A-AFFY-45

1439845_at
type: EFO_0005072
part of: A-AFFY-45

Kif5c UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0442395131037
p value: 0.0268873941253854
refers to: 1422945_a_at
refers to: Kif5c
t statistic: 5.0983323017998

Pttg1
type: EnsemblDatabaseReference

Pdk4 DOWN in 'TBP105Q' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.04017252912824
p value: 0.0113080367333593
refers to: Pdk4
refers to: 1417273_at
t statistic: -6.49647255132224

Pvrl3
type: EnsemblDatabaseReference

1435163_at
type: EFO_0005072
part of: A-AFFY-45

E-MEXP-1314
type: microarray 1colour mrna differential
RO_0002162: Mus musculus
description: Transcription profiles were obtained for 2-month old mice. Three lines (WT, TBP-13Q12, and TBP105Q) were used in these experiments. Wild-type and 13Q mice are normal. The 13Q mice overexpress the normal protein on the RNA but not protein level and do not show a phenotype. The 105Q mice express a mutant version of the protein TBP and faithfully model the disease SCA17 (spinocerebellar ataxia-17, huntington disease-like 4, HDL4). The constructs containing mixed CAG/CAA trinucleotide repeats (and encoding polyglutamine tracts) of variable length were made using a previously described method (Michalik A et al., Biotechniques, 2001). Briefly, synthetic CAG/CAA oligonucleotides were subcloned into a cDNA construct of the normal mouse (13 CAG/CAA) TBP gene. Because of the mixed nature of the repeat, its length is stable in mitotic and meiotic transmission.
uses data from: http://identifiers.org/pubmed/17994014

(Sample) sex/female
type: EFO_0001265
property type: sex
property value: female

Slc1a2 UP in 'TBP13Q' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.58533240853986
p value: 0.00405578427724471
refers to: Slc1a2
refers to: 1439940_at
t statistic: 9.02731592023343

Pdk4
type: EnsemblDatabaseReference

(Sample) genotype/TBP105Q
type: EFO_0000001
property type: genotype
property value: TBP105Q

Analysis of 'TBP13Q' vs 'wild type'
type: MicroarrayDifferentialExpressionAnalysis

Slc1a2
type: EnsemblDatabaseReference

(Assay) TBP-105Qa
type: Assay
has participant: A-AFFY-45

Efhd2 DOWN in 'TBP105Q' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.04772724413822
p value: 0.0251727457161477
refers to: Efhd2
refers to: 1437478_s_at
t statistic: -5.15971246344682

1419344_at
type: EFO_0005072
part of: A-AFFY-45

Kif5c
type: EnsemblDatabaseReference

Soga3
type: EnsemblDatabaseReference

Hspa1b
type: EnsemblDatabaseReference

1417432_a_at
type: EFO_0005072
part of: A-AFFY-45

(Factor value) GENOTYPE/TBP105Q
type: EFO_0000001
property type: GENOTYPE
property value: TBP105Q

A-AFFY-45
type: EFO_0000269