LDLR DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CRK DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
MAT2A DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
Transcriptional profiling was utilized to define the biological pathways of gingival epithelial cells modulated by co-culture with the oral pathogenic Porphyromonas gingivalis and Aggregatibacter (formerly actinobacillus) actinomycetemcomitans. We used microarrays to detail the global programme of gene expression underlying infection and identified distinct classes of up- and down-regulated genes during this process. Experiment Overall Design: Gingival epithelial HIGK cells were sham infected (CTRL) and infected with either the oral pathogenic P. gingivalis (Pg) or A. actinomycetemcomitans (Aa). These samples were hybridized to Affymetrix microarrays. Understanding how host cells have adapted to pathogens, and how barrier cells respond to limit their impact, provides a mechanistic biological basis of microbial disease in the mixed bacterial-human ecosystem of the oral cavity.
MGC16275 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SLC52A2 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CCNE2 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
TPM1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
RFC3 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
YIPF5 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
ATP6V1A DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CSF3 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
HAS2 UP in 'Porphyromonas gingivalis' vs 'uninfected'
CDV3 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
EIF5 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
FN1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
(Assay) HIGK cells infected with Aggregatibacter actinomycetemcomitans, biological rep2
HIGK cells infected with Aggregatibacter actinomycetemcomitans, biological rep2
HSPA4 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
KRT17 UP in 'Porphyromonas gingivalis' vs 'uninfected'
RAB2A UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
TOP2A DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
HAS2 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
RAD21 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CTGF UP in 'Porphyromonas gingivalis' vs 'uninfected'
EIF5A UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
Analysis of 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SCYL2 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
G3BP2 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CXCL1 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
DUSP10 UP in 'Porphyromonas gingivalis' vs 'uninfected'
SPC25 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PTGS2 UP in 'Porphyromonas gingivalis' vs 'uninfected'
RRM1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PTPRE DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
FLRT2 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
HES1 UP in 'Porphyromonas gingivalis' vs 'uninfected'
LAMP3 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
MIR22HG DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
HES1 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
WAC DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
EHF DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CD46 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
ZNF205 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CCNG2 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PTGER4 UP in 'Porphyromonas gingivalis' vs 'uninfected'
(Assay) Sham infected HIGK cells, biological rep2 (1778)
Sham infected HIGK cells, biological rep2 (1778)
CXCL8 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
LUC7L3 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PSEN1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CXCL2 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
DDX3X DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
(Factor value) INFECT/Porphyromonas gingivalis
ADM UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
JAG1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
DEGS1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SGPP1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
(Assay) Sham infected HIGK cells, biological rep1 (1777)
Sham infected HIGK cells, biological rep1 (1777)
PDLIM5 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CYP24A1 UP in 'Porphyromonas gingivalis' vs 'uninfected'
HK2 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SEC63 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
NAA35 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
TMPO DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
ITGB6 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CDK1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
HS3ST2 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
NUSAP1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CALD1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
TNFAIP3 UP in 'Porphyromonas gingivalis' vs 'uninfected'
NFIL3 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PICALM DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
TRA2B DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
DNAJB6 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SCG5 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
BHLHE40 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CALD1 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
(Assay) HIGK cells infected with Aggregatibacter actinomycetemcomitans, biological rep4
HIGK cells infected with Aggregatibacter actinomycetemcomitans, biological rep4
MCOLN3 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SLC39A6 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
ZNF281 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
IFI44L UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
IL6ST DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
RP11-661A12.7 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SON DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CYP1B1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
THBS1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
Analysis of 'Porphyromonas gingivalis' vs 'uninfected'
DUSP1 UP in 'Porphyromonas gingivalis' vs 'uninfected'
CALD1 UP in 'Porphyromonas gingivalis' vs 'uninfected'
RAB1A DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
ZNF654 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PPP1R3C UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
EFNA1 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
ZC3H12A UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
EIF4G1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
TMX1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
TRIM22 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
APP DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
ETS1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
LPIN1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
IGFBP3 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SRSF10 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
GNA13 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PLK2 UP in 'Porphyromonas gingivalis' vs 'uninfected'
MTMR1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PTRF DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
NFKBIA UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
NUAK2 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
DUSP4 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SERPINB2 UP in 'Porphyromonas gingivalis' vs 'uninfected'
CALM1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
GADD45A UP in 'Porphyromonas gingivalis' vs 'uninfected'
C1orf116 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
DUSP5 UP in 'Porphyromonas gingivalis' vs 'uninfected'
(Factor value) INFECT/Aggregatibacter actinomycetemcomitans
(Assay) HIGK cells infected with Aggregatibacter actinomycetemcomitans, biological rep3
HIGK cells infected with Aggregatibacter actinomycetemcomitans, biological rep3
PAPOLA DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CDH1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
B3GNT2 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PRPF4B DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
IL6 UP in 'Porphyromonas gingivalis' vs 'uninfected'
EID1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
C10orf10 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
HIST1H4C DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
NFYB DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CLIC4 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
DDIT4 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
TNFAIP3 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CSF2 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
VAMP3 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
(Assay) Sham infected HIGK cells, biological rep3 (1779)
Sham infected HIGK cells, biological rep3 (1779)
(Assay) HIGK cells infected with Porphyromonas gingivalis, biological rep1
HIGK cells infected with Porphyromonas gingivalis, biological rep1
ADRB2 UP in 'Porphyromonas gingivalis' vs 'uninfected'
FEM1B UP in 'Porphyromonas gingivalis' vs 'uninfected'
RDX DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SPAG8 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PDLIM5 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
EZR DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
(Assay) HIGK cells infected with Porphyromonas gingivalis, biological rep4
HIGK cells infected with Porphyromonas gingivalis, biological rep4
IFI6 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
ITGA6 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
(Assay) Sham infected HIGK cells, biological rep4 (1780)
Sham infected HIGK cells, biological rep4 (1780)
HIPK3 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PEG10 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
(Assay) HIGK cells infected with Porphyromonas gingivalis, biological rep2
HIGK cells infected with Porphyromonas gingivalis, biological rep2
RND3 UP in 'Porphyromonas gingivalis' vs 'uninfected'
CALU DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
ID3 UP in 'Porphyromonas gingivalis' vs 'uninfected'
FBXW11 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
HILPDA UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
(Assay) HIGK cells infected with Aggregatibacter actinomycetemcomitans, biological rep1
HIGK cells infected with Aggregatibacter actinomycetemcomitans, biological rep1
MCL1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
NEK2 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
PTPN12 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
B4GALT1 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
OAS1 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SLC2A3 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
TXNIP DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SOD2 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
(Assay) HIGK cells infected with Porphyromonas gingivalis, biological rep3
HIGK cells infected with Porphyromonas gingivalis, biological rep3
EDN1 UP in 'Porphyromonas gingivalis' vs 'uninfected'
ARF4 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
SRSF3 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
TOR1AIP1 DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
FST DOWN in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'
CXCL3 UP in 'Aggregatibacter actinomycetemcomitans' vs 'uninfected'