SMARCA2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MTMR1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TRIQK DOWN in 'aldosterone-producing adenoma' vs 'normal'
RP11-247L20.4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PLEKHA2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLMAP DOWN in 'aldosterone-producing adenoma' vs 'normal'
SOCS3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AVPR1A DOWN in 'aldosterone-producing adenoma' vs 'normal'
NXPH1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FAIM2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
JAZF1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PPP2CA DOWN in 'aldosterone-producing adenoma' vs 'normal'
CPPED1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NFYB DOWN in 'aldosterone-producing adenoma' vs 'normal'
RPRD1A DOWN in 'aldosterone-producing adenoma' vs 'normal'
NR3C2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SCG2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KCND3 UP in 'aldosterone-producing adenoma' vs 'normal'
HS3ST3B1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NMRK2 UP in 'aldosterone-producing adenoma' vs 'normal'
GPR155 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ELOVL6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TUBGCP3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GRK5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KBTBD2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HMOX1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MAN1A1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
STK17A DOWN in 'aldosterone-producing adenoma' vs 'normal'
URI1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HIPK3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AOX1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FCN2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NET1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FGD4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FBXL4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ICAM1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FAM198B DOWN in 'aldosterone-producing adenoma' vs 'normal'
ME2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DDX42 DOWN in 'aldosterone-producing adenoma' vs 'normal'
APLP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC2A3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FGF12 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IRF6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HSDL2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ACKR3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PDGFD DOWN in 'aldosterone-producing adenoma' vs 'normal'
STAM2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
EMP2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
APPL1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CLIP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SWAP70 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SDPR DOWN in 'aldosterone-producing adenoma' vs 'normal'
BCL2L11 DOWN in 'aldosterone-producing adenoma' vs 'normal'
BMPR2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZNF431 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ANGPTL1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CDC37L1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ATP2A3 UP in 'aldosterone-producing adenoma' vs 'normal'
CDKN1C DOWN in 'aldosterone-producing adenoma' vs 'normal'
TSFM DOWN in 'aldosterone-producing adenoma' vs 'normal'
GCLM DOWN in 'aldosterone-producing adenoma' vs 'normal'
MEX3D DOWN in 'aldosterone-producing adenoma' vs 'normal'
GCH1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ATP2B2 UP in 'aldosterone-producing adenoma' vs 'normal'
NAALAD2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CADM1 UP in 'aldosterone-producing adenoma' vs 'normal'
CCL8 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LINC01314 UP in 'aldosterone-producing adenoma' vs 'normal'
STAT5B DOWN in 'aldosterone-producing adenoma' vs 'normal'
C15orf27 UP in 'aldosterone-producing adenoma' vs 'normal'
NRK DOWN in 'aldosterone-producing adenoma' vs 'normal'
CNOT8 DOWN in 'aldosterone-producing adenoma' vs 'normal'
EPB41L3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GALNT10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CEP104 DOWN in 'aldosterone-producing adenoma' vs 'normal'
BACH1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CEP44 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DSTYK DOWN in 'aldosterone-producing adenoma' vs 'normal'
KLF6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TCF7L2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NAB1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SPTLC1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC8B1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FMO3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SNTB2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HBP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GXYLT2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
REPIN1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TUSC3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
STXBP5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZNF277 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TOR1AIP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KCNJ5 UP in 'aldosterone-producing adenoma' vs 'normal'
MTFR1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MYOF DOWN in 'aldosterone-producing adenoma' vs 'normal'
C5orf24 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IREB2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TCF21 DOWN in 'aldosterone-producing adenoma' vs 'normal'
JAG1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TIA1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PCP4 UP in 'aldosterone-producing adenoma' vs 'normal'
CYP20A1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC1A4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NEAT1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZNF385B DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZNF107 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FAM129A DOWN in 'aldosterone-producing adenoma' vs 'normal'
HIP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RP2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MAP4K5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RP11-283I3.6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IMPACT DOWN in 'aldosterone-producing adenoma' vs 'normal'
BIVM DOWN in 'aldosterone-producing adenoma' vs 'normal'
VCAN DOWN in 'aldosterone-producing adenoma' vs 'normal'
PPP1R12A DOWN in 'aldosterone-producing adenoma' vs 'normal'
THBD DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC24A3 UP in 'aldosterone-producing adenoma' vs 'normal'
WSCD1 UP in 'aldosterone-producing adenoma' vs 'normal'
ACOX1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
C11orf54 DOWN in 'aldosterone-producing adenoma' vs 'normal'
COL15A1 UP in 'aldosterone-producing adenoma' vs 'normal'
ZC3H7A DOWN in 'aldosterone-producing adenoma' vs 'normal'
BRMS1L DOWN in 'aldosterone-producing adenoma' vs 'normal'
DEPTOR DOWN in 'aldosterone-producing adenoma' vs 'normal'
CLMP DOWN in 'aldosterone-producing adenoma' vs 'normal'
KMT2E DOWN in 'aldosterone-producing adenoma' vs 'normal'
ADD3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DAK DOWN in 'aldosterone-producing adenoma' vs 'normal'
PHOX2B DOWN in 'aldosterone-producing adenoma' vs 'normal'
SAMHD1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NRIP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DCAF16 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AGA DOWN in 'aldosterone-producing adenoma' vs 'normal'
MS4A7 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NEBL DOWN in 'aldosterone-producing adenoma' vs 'normal'
FZD6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PTPRK DOWN in 'aldosterone-producing adenoma' vs 'normal'
KLHL8 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HOXB8 UP in 'aldosterone-producing adenoma' vs 'normal'
KDSR DOWN in 'aldosterone-producing adenoma' vs 'normal'
MLIP DOWN in 'aldosterone-producing adenoma' vs 'normal'
HS3ST3A1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FAM117B DOWN in 'aldosterone-producing adenoma' vs 'normal'
CCBE1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ASPH DOWN in 'aldosterone-producing adenoma' vs 'normal'
CD69 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HCN2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CDC14B DOWN in 'aldosterone-producing adenoma' vs 'normal'
KCTD18 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CYYR1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LACTB2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RP11-364B14.3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FGG DOWN in 'aldosterone-producing adenoma' vs 'normal'
TMED5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TIE1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CEBPZOS DOWN in 'aldosterone-producing adenoma' vs 'normal'
TLR3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PLAGL1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RBP4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TMEM150C DOWN in 'aldosterone-producing adenoma' vs 'normal'
AMIGO2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CAT DOWN in 'aldosterone-producing adenoma' vs 'normal'
JADE1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PSD3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CD36 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NDUFS1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AZIN1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
OTUD1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
THOC2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HNRNPH1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SCNN1A DOWN in 'aldosterone-producing adenoma' vs 'normal'
HOXB9 UP in 'aldosterone-producing adenoma' vs 'normal'
DAGLB DOWN in 'aldosterone-producing adenoma' vs 'normal'
NDRG3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CH25H DOWN in 'aldosterone-producing adenoma' vs 'normal'
TMEM33 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KLF7 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FOSB DOWN in 'aldosterone-producing adenoma' vs 'normal'
PERP DOWN in 'aldosterone-producing adenoma' vs 'normal'
ESYT2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DBT DOWN in 'aldosterone-producing adenoma' vs 'normal'
DCN DOWN in 'aldosterone-producing adenoma' vs 'normal'
CALB2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NRBF2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLITRK4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PTGER3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GNAS DOWN in 'aldosterone-producing adenoma' vs 'normal'
PTPRG DOWN in 'aldosterone-producing adenoma' vs 'normal'
TMOD3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RP3-428L16.2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CPSF2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RET DOWN in 'aldosterone-producing adenoma' vs 'normal'
TMEM108 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FAM13A DOWN in 'aldosterone-producing adenoma' vs 'normal'
ADAMTSL2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LIN7C DOWN in 'aldosterone-producing adenoma' vs 'normal'
S100A10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CTSC DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC41A2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GBP2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
EFEMP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GJA1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
JUN DOWN in 'aldosterone-producing adenoma' vs 'normal'
PTPRC DOWN in 'aldosterone-producing adenoma' vs 'normal'
ABCD3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GSTA1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ELMOD1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SRR DOWN in 'aldosterone-producing adenoma' vs 'normal'
TRIB1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MNDA DOWN in 'aldosterone-producing adenoma' vs 'normal'
EPB41L4B DOWN in 'aldosterone-producing adenoma' vs 'normal'
DPP6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IPO11 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SCD5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KCTD3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ACYP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CLRN1 UP in 'aldosterone-producing adenoma' vs 'normal'
ANKRD29 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PPP6R3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CYP11B2 UP in 'aldosterone-producing adenoma' vs 'normal'
PAPOLA DOWN in 'aldosterone-producing adenoma' vs 'normal'
AC010524.4 UP in 'aldosterone-producing adenoma' vs 'normal'
RDH10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
VTA1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PCDH7 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RP11-485G4.2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PABPC5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IL1B DOWN in 'aldosterone-producing adenoma' vs 'normal'
CDC40 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SYT1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ABCC3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DPY19L4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TFPI DOWN in 'aldosterone-producing adenoma' vs 'normal'
ABI1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SGMS1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MCM9 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC29A1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LEPROT DOWN in 'aldosterone-producing adenoma' vs 'normal'
DDC DOWN in 'aldosterone-producing adenoma' vs 'normal'
ALAD DOWN in 'aldosterone-producing adenoma' vs 'normal'
BEX5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AQP11 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ETNK1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FCGBP DOWN in 'aldosterone-producing adenoma' vs 'normal'
HPGD DOWN in 'aldosterone-producing adenoma' vs 'normal'
ATF3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
EFNB2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NAA40 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CLCN3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
C4orf32 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RIOK3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZFP36L2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DLG2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RAB8B DOWN in 'aldosterone-producing adenoma' vs 'normal'
LRRN4CL DOWN in 'aldosterone-producing adenoma' vs 'normal'
SOX17 DOWN in 'aldosterone-producing adenoma' vs 'normal'
VEGFC DOWN in 'aldosterone-producing adenoma' vs 'normal'
CCDC6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CITED2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GPM6B DOWN in 'aldosterone-producing adenoma' vs 'normal'
PRKACB DOWN in 'aldosterone-producing adenoma' vs 'normal'
LPHN3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MLXIP DOWN in 'aldosterone-producing adenoma' vs 'normal'
FAM19A4 UP in 'aldosterone-producing adenoma' vs 'normal'
CSRNP3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NR1H4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RHOBTB3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PSEN1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MAP3K5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZEB1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RAB31 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DOCK10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AQP2 UP in 'aldosterone-producing adenoma' vs 'normal'
IL33 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PPP3CA DOWN in 'aldosterone-producing adenoma' vs 'normal'
ABHD10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NADK2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PCDH10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GSPT1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
L1CAM DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC9A7 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SERPINI1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HERPUD2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SFXN4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AKIRIN2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FGF14-AS2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PPP1R15A DOWN in 'aldosterone-producing adenoma' vs 'normal'
PRKD1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TOPORS DOWN in 'aldosterone-producing adenoma' vs 'normal'
MLLT10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PCSK1N DOWN in 'aldosterone-producing adenoma' vs 'normal'
SS18 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MAML2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ANKRD28 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PXMP4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ETFDH DOWN in 'aldosterone-producing adenoma' vs 'normal'
CHRDL1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AOC3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
UCHL1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
VAMP4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC16A9 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IDS DOWN in 'aldosterone-producing adenoma' vs 'normal'
PIGA DOWN in 'aldosterone-producing adenoma' vs 'normal'
SNAP23 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NFATC2IP DOWN in 'aldosterone-producing adenoma' vs 'normal'
FGFR1OP2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KBTBD6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IFI16 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IKZF4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RAB22A DOWN in 'aldosterone-producing adenoma' vs 'normal'
HAND2-AS1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
BLOC1S6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
UBE4B DOWN in 'aldosterone-producing adenoma' vs 'normal'
BIN1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZHX1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HSPA12A DOWN in 'aldosterone-producing adenoma' vs 'normal'
LINC01420 DOWN in 'aldosterone-producing adenoma' vs 'normal'
EHD1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SERBP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ACSS3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZFP36 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LRIF1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FGFR2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RP11-172H24.4 UP in 'aldosterone-producing adenoma' vs 'normal'
GPRC5C UP in 'aldosterone-producing adenoma' vs 'normal'
KRCC1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
OMA1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ARL6IP5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PER3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TMEM56 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ADIPOQ DOWN in 'aldosterone-producing adenoma' vs 'normal'
SCD DOWN in 'aldosterone-producing adenoma' vs 'normal'
PLCL1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TSPAN8 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GATA5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PAPSS2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PPP1R13L DOWN in 'aldosterone-producing adenoma' vs 'normal'
GLS DOWN in 'aldosterone-producing adenoma' vs 'normal'
GMFB DOWN in 'aldosterone-producing adenoma' vs 'normal'
SRPK2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RTN1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MAFK DOWN in 'aldosterone-producing adenoma' vs 'normal'
EPS8 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZBED6CL DOWN in 'aldosterone-producing adenoma' vs 'normal'
C10orf32 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CD14 DOWN in 'aldosterone-producing adenoma' vs 'normal'
WISP2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SPIRE1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ACTR3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
WNK3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PDLIM5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SPATA13 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CCNG2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PTGR1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SNTB1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DDX59 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TIFA DOWN in 'aldosterone-producing adenoma' vs 'normal'
MTUS1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CD164 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TNFSF10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
APOOL DOWN in 'aldosterone-producing adenoma' vs 'normal'
SMIM14 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PSD4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PENK DOWN in 'aldosterone-producing adenoma' vs 'normal'
TMEM165 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GTF2I DOWN in 'aldosterone-producing adenoma' vs 'normal'
AKR1C3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KLHL24 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CEP76 DOWN in 'aldosterone-producing adenoma' vs 'normal'
BAMBI DOWN in 'aldosterone-producing adenoma' vs 'normal'
H2AFY DOWN in 'aldosterone-producing adenoma' vs 'normal'
NAP1L3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AHR DOWN in 'aldosterone-producing adenoma' vs 'normal'
ABCB4 UP in 'aldosterone-producing adenoma' vs 'normal'
FAM126B DOWN in 'aldosterone-producing adenoma' vs 'normal'
TMEM5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CHIC2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MCL1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CLIC4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
C7orf31 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CYB5A DOWN in 'aldosterone-producing adenoma' vs 'normal'
MCM3AP DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZMYND11 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SPAST DOWN in 'aldosterone-producing adenoma' vs 'normal'
(Sample) disease/aldosterone-producing adenoma
MORC4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HTR4 UP in 'aldosterone-producing adenoma' vs 'normal'
ETS2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NCOA2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SGCB DOWN in 'aldosterone-producing adenoma' vs 'normal'
KDM1B DOWN in 'aldosterone-producing adenoma' vs 'normal'
ARFGEF1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MARCO DOWN in 'aldosterone-producing adenoma' vs 'normal'
TCEAL7 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GADD45B DOWN in 'aldosterone-producing adenoma' vs 'normal'
RGS5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HES1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
EFNA1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FAM20B DOWN in 'aldosterone-producing adenoma' vs 'normal'
TH DOWN in 'aldosterone-producing adenoma' vs 'normal'
ACSL4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SYNPO2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FAM73A DOWN in 'aldosterone-producing adenoma' vs 'normal'
RHOJ DOWN in 'aldosterone-producing adenoma' vs 'normal'
PANX1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RAB5A DOWN in 'aldosterone-producing adenoma' vs 'normal'
CALN1 UP in 'aldosterone-producing adenoma' vs 'normal'
SLC40A1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ADAM9 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GINM1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LGR4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ECEL1 UP in 'aldosterone-producing adenoma' vs 'normal'
TTC7A DOWN in 'aldosterone-producing adenoma' vs 'normal'
RAB27A DOWN in 'aldosterone-producing adenoma' vs 'normal'
BCL6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HMGB2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
EFCAB7 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LURAP1L DOWN in 'aldosterone-producing adenoma' vs 'normal'
BAG2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NEGR1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LRRN3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IGF1R DOWN in 'aldosterone-producing adenoma' vs 'normal'
MST4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CHGA DOWN in 'aldosterone-producing adenoma' vs 'normal'
PBRM1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PNMA2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KIAA1217 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SUPT16H DOWN in 'aldosterone-producing adenoma' vs 'normal'
HIRA DOWN in 'aldosterone-producing adenoma' vs 'normal'
(Factor value) DISEASE/aldosterone-producing adenoma
DUSP6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CAPS UP in 'aldosterone-producing adenoma' vs 'normal'
DPYD DOWN in 'aldosterone-producing adenoma' vs 'normal'
ALDH1A3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KCTD12 DOWN in 'aldosterone-producing adenoma' vs 'normal'
USP2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
B4GALT6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GMCL1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
BCAT1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NUP160 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CXCL12 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CYP26B1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LIX1L DOWN in 'aldosterone-producing adenoma' vs 'normal'
ADH1B DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC7A1 UP in 'aldosterone-producing adenoma' vs 'normal'
PSPH DOWN in 'aldosterone-producing adenoma' vs 'normal'
TMEM64 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SMC1A DOWN in 'aldosterone-producing adenoma' vs 'normal'
RP4-639F20.1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
BCO2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MAPK4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CDH12 DOWN in 'aldosterone-producing adenoma' vs 'normal'
INSM1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RSF1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GTF2H3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SAMSN1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DNASE1L3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
Analysis of 'aldosterone-producing adenoma' vs 'normal'
GLIPR1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC44A3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CNN3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FOSL2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
UBE2D1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IRX3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NDUFAF7 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZNF738 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SEMA3C DOWN in 'aldosterone-producing adenoma' vs 'normal'
LRRC58 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TIPRL DOWN in 'aldosterone-producing adenoma' vs 'normal'
ACO1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TRIM8 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KPNA5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IL17D UP in 'aldosterone-producing adenoma' vs 'normal'
ZNF765 DOWN in 'aldosterone-producing adenoma' vs 'normal'
The source of aldosterone in 30 to 40 % of patients with primary hyperaldosteronism (PA) is unilateral aldosterone-producing adenoma (APA). The mechanisms causing elevated aldosterone production in APA are unknown. Herein, we examined expression of G-protein coupled receptors (GPCR) in APA and demonstrate that compared to normal adrenals there is a general elevation of certain GPCR in many APA and/or ectopic expression of GPCR in others. RNA samples from normal adrenals (n = 5), APAs (n = 10), and cortisol-producing adenomas (CPAs) (n=13) were used on 15 genomic expression arrays, each of which included 223 GPCR transcripts presented in at least one out of 15 of the independent microarrays. The array results were confirmed using real-time RT-PCR (qPCR). Four GPCR transcripts exhibited a statistically significant increase that was greater than 3-fold compared to normal adrenals, suggesting a general increase in expression compared to normal adrenal glands. Four GPCR transcripts exhibited a greater than 15-fold increase of expression in one or more of the APA samples compared to normal adrenals. qPCR analysis confirmed array data and found the receptors with the highest fold increase in APA expression to be luteinizing hormone receptor (LH-R), serotonin receptor 4 (HTR4), gonadotropin-releasing hormone receptor (GnRHR), glutamate receptor metabotropic 3 (GRM3), endothelin receptor type B-like protein (GPR37), and ACTH receptor (MC2R). There are also sporadic increased expressions of these genes in the CPAs. Together, these findings suggest a potential role of altered GPCR expression in many cases of PA and provide candidate GPCR for further study. Keywords: disease state analysis Normal human adult adrenals were obtained through the Cooperative Human Tissue Network (Philadelphia, PA) and Clontech (Palo Alto, CA). All the normal adrenal samples came from patients that underwent adrenalectomy along with a renalectomy due to renal carcinoma. The adrenal samples acquired from autopsies were obtained no more than six hours after death, and it was confirmed that the causes of death were unrelated to adrenal function. Real-time quantitative RT-PCR was used to check the legitimacy of the normal control adrenal samples. Examination of tissue sections from each adrenal gland also suggested normal histology. The APA samples were obtained from the Departments of Medicine at UT Southwestern and Division of Endocrinology at the University of Padua. All APA samples were from ConnâÂÂs Syndrome patients with significantly elevated circulating aldosterone that was lowered to the normal range after surgical removal of the tumor. Thirty-two adenomas were collected from patients with primary hyperaldosteronism. Twenty-eight of these adenomas had levels of CYP11B2 that were two standard deviations (SD) greater than seen in normal adrenal glands and these samples were used for analyses. It is currently not clear if the adenomas with low CYP11B2 expression are the source of aldosterone in these patients. Other studies suggest that subcapsular micronodules have varying expression of steroidogenic enzymes-some with aldosterone synthase and some without (Shigematsu et al., 2006). Future studies are required to determine if some tumor-bearing adrenals from primary hyperaldosteronsim patients also have small CYP11B2 positive micronodules as the source of aldosterone production. The cortisol-producing adenoma (CPA) tissues were obtained from Division of Endocrinology at the University of Padua from patients with CushingâÂÂs syndrome. Each of the patients was cured following surgical removal of the adenoma. The use of these tissues was approved by the Institutional Review Boards of the University of Texas Southwestern Medical Center (Dallas, TX), the Medical College of Georgia (Augusta, GA), and University of Padua (Italy). In addition, this study was approved by the ethical committee at the University of Padua, and informed consent was obtained from every patient. Microarray Analysis Total RNA isolated from normal adult adrenal glands (n = 5) and APA (n = 10) were used on 15 genomic expression arrays. In brief, RNA was hybridized to an Affymetrix human HG-U133+2 oligonucleotide microarray set containing 54,675 probe sets representing approximately 40,500 independent human genes. The arrays were scanned at high resolution using an Affymetrix GeneChip Scanner 3000 located at Medical College of Georgia Microarray Core Facility (Augusta, GA). Results were analyzed using GeneSpring GX 7.3.1 software (Silicon Genetics, Redwood City, CA) to identify differences in expression of GPCR between normal adult adrenal and APA. RNA Extraction The tissue was pulverized in liquid nitrogen to a powder. Total RNA was extracted using TRIzol Reagent (Invitrogen, Carlsbad, CA). The purity and integrity of the RNA were assessed by the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, CA) and its quantity was determined by NanoDrop spectrophotometer (NanoDrop Technologies, Wilmington, DE). cDNA Synthesis 2 ÃÂµg of total RNA was reverse transcribed using the High Capacity cDNA Archive Kit (Applied Biosystems, Foster City, CA) following manufacturer recommendations and incubated at 25 ÃÂºC for 10 min, and 37 ÃÂºC for 2 h. The synthesized cDNA was subjected to 1:10 dilution and stored at -20ÃÂºC. Real-Time Quantitative PCR Primers and probes for the amplification of the selected GPCR sequences were performed using the TaqMan Gene Expression Assays (Applied Biosystems, Foster City, CA) based on published sequences for genes encoding the respective human GPCR. The gene symbols and AB assay numbers are listed in Table 1. The primer and probe set for human CYP11B2 was designed using Primer Express 3.0 (Applied Biosystems, Foster City, CA) and purchased from IDT (Integrated DNA Technologies, Inc, IA) as published previously (Saner-Amigh et al., 2006). In brief: Forward: 5âÂÂ-GGCAGAGGCAGAGATGCTG-3âÂÂ, Reverse: 5âÂÂ- CTTGAGTTAGTGTCTCCACCAGGA-3âÂÂ, Probe: 5âÂÂ-CTGCACCACGTGCTGAAGCACT-3âÂÂ. PCR reactions were performed using the ABI 7500 Fast Real-Time PCR System (Applied Biosystems, Foster City, CA) with a total volume of 20 ÃÂ¼l per reaction following the reaction parameters recommended by the manufacturer, which includes denaturation at 95ÃÂºC for 20 s followed by amplification for 40 cycles (95ÃÂºC at 3 s, 60ÃÂºC at 30 s, fluorescence measurement). For each GPCR the 20 ÃÂ¼l total volume consisted of 10 ÃÂµl TaqMan Fast Universal PCR Master Mix (2X) (Applied Biosystems, Foster City, CA), 900 nM of each primer, 400 nM of the probe and 5 ÃÂ¼l of each first-strand cDNA sample. CYP11B2 reaction mix consisted of 10ÃÂµl TaqMan PCR Master Mix (2X) (Applied Biosystems, Foster City, CA), 100 nM of primer/probe mix and 5 ÃÂ¼l of each first-strand cDNA sample. 18s rRNA was detected and quantified using the TaqMan Ribosomal RNA Control Reagents (Vic Probe) (Applied Biosystems, Foster City, CA). Each reaction included 10 ÃÂµl of TaqMan PCR Master Mix (2X) (Applied Biosystems, Foster City, CA), 100 nM probe and 50 nM primers. Negative controls contained water instead of first-strand cDNA. Quantitative normalization of cDNA in each tissue-derived sample was performed using expression of 18s rRNA as an internal control. The generated Ct value of each gene was normalized by its respected Ct value of 18s rRNA (âÂÂCt). Then each gene was further normalized using the average âÂÂCt value of the normal adult adrenal (âÂÂÃ¢ÂÂCt). The final fold-expression changes were calculated using the equation 2-âÂÂÃ¢ÂÂCt (Livak & Schmittgen, 2001). Statistical Analysis Data were analyzed and compared to control values (mean of normal adrenal samples) using the Mann-Whitney Rank Sum test with the SigmaStat 3.0 software package (SPSS, Chicago, IL). Results were considered significantly different when p value was ïÂÂ£ 0.05.
ANKS1B DOWN in 'aldosterone-producing adenoma' vs 'normal'
TRA2B DOWN in 'aldosterone-producing adenoma' vs 'normal'
JAM3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HADHA DOWN in 'aldosterone-producing adenoma' vs 'normal'
GSE1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZBTB10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NEFH DOWN in 'aldosterone-producing adenoma' vs 'normal'
MFN2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FBN1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RBM48 DOWN in 'aldosterone-producing adenoma' vs 'normal'
VPREB3 UP in 'aldosterone-producing adenoma' vs 'normal'
ZEB2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SDHC DOWN in 'aldosterone-producing adenoma' vs 'normal'
PCMTD2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ANO4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PDE4B DOWN in 'aldosterone-producing adenoma' vs 'normal'
IL6ST DOWN in 'aldosterone-producing adenoma' vs 'normal'
PPIL4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LRRFIP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PPFIBP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PPID DOWN in 'aldosterone-producing adenoma' vs 'normal'
SETD9 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SFRP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ELF1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
STAG1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GIMAP2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MRPL19 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NDUFA10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NAV3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CAST DOWN in 'aldosterone-producing adenoma' vs 'normal'
TRIM6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PNRC2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZMYM5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RETSAT DOWN in 'aldosterone-producing adenoma' vs 'normal'
ITSN1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CYB561A3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SGPP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CHPT1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HELQ DOWN in 'aldosterone-producing adenoma' vs 'normal'
NGEF DOWN in 'aldosterone-producing adenoma' vs 'normal'
CBX3 UP in 'aldosterone-producing adenoma' vs 'normal'
LMTK2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GMPS DOWN in 'aldosterone-producing adenoma' vs 'normal'
ARHGEF40 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KLF13 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PCGF5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC35F5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DPY19L1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RMDN1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PER2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
COG3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
WFS1 UP in 'aldosterone-producing adenoma' vs 'normal'
CFLAR DOWN in 'aldosterone-producing adenoma' vs 'normal'
TFE3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TTC39C DOWN in 'aldosterone-producing adenoma' vs 'normal'
OPN3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TOX2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
C1RL DOWN in 'aldosterone-producing adenoma' vs 'normal'
GPC3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MATR3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PHYHIPL DOWN in 'aldosterone-producing adenoma' vs 'normal'
INPP5F DOWN in 'aldosterone-producing adenoma' vs 'normal'
TRRAP DOWN in 'aldosterone-producing adenoma' vs 'normal'
AADAC DOWN in 'aldosterone-producing adenoma' vs 'normal'
C14orf142 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DBH DOWN in 'aldosterone-producing adenoma' vs 'normal'
CCDC50 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ITPRIPL2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
VDR UP in 'aldosterone-producing adenoma' vs 'normal'
CELF1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
IL20RA DOWN in 'aldosterone-producing adenoma' vs 'normal'
SNRK DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZFP36L1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CLDN1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SUPT6H DOWN in 'aldosterone-producing adenoma' vs 'normal'
PDZRN3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CHGB DOWN in 'aldosterone-producing adenoma' vs 'normal'
GLRB DOWN in 'aldosterone-producing adenoma' vs 'normal'
PALMD DOWN in 'aldosterone-producing adenoma' vs 'normal'
MEIS1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SRSF10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AC096772.6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DENND4A DOWN in 'aldosterone-producing adenoma' vs 'normal'
FAM115A DOWN in 'aldosterone-producing adenoma' vs 'normal'
LINC01128 DOWN in 'aldosterone-producing adenoma' vs 'normal'
QKI DOWN in 'aldosterone-producing adenoma' vs 'normal'
G0S2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TPM4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PIGK DOWN in 'aldosterone-producing adenoma' vs 'normal'
SLC39A6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ASF1A DOWN in 'aldosterone-producing adenoma' vs 'normal'
LUM DOWN in 'aldosterone-producing adenoma' vs 'normal'
ARHGAP5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GSTA3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KLHL4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
C15orf40 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MCF2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MDFIC DOWN in 'aldosterone-producing adenoma' vs 'normal'
TCEAL2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MFSD6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PPP1R3B DOWN in 'aldosterone-producing adenoma' vs 'normal'
YTHDF3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CSDC2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
OSMR DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZNF260 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KIAA1715 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GPAM DOWN in 'aldosterone-producing adenoma' vs 'normal'
FRMD6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TBC1D32 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DPT DOWN in 'aldosterone-producing adenoma' vs 'normal'
GATM DOWN in 'aldosterone-producing adenoma' vs 'normal'
C1orf85 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FH DOWN in 'aldosterone-producing adenoma' vs 'normal'
PRKCA DOWN in 'aldosterone-producing adenoma' vs 'normal'
MED6 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DSEL DOWN in 'aldosterone-producing adenoma' vs 'normal'
TRIB2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
COPA DOWN in 'aldosterone-producing adenoma' vs 'normal'
DRAM1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NUDT4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CYCS DOWN in 'aldosterone-producing adenoma' vs 'normal'
FRYL DOWN in 'aldosterone-producing adenoma' vs 'normal'
C3orf33 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RBMS3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GBP1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PSPC1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ECHDC3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PLEK2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PCSK2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ELK3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
UNC5A DOWN in 'aldosterone-producing adenoma' vs 'normal'
REEP3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CCL21 DOWN in 'aldosterone-producing adenoma' vs 'normal'
FOS DOWN in 'aldosterone-producing adenoma' vs 'normal'
CNR1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LSM5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
EML4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SCN7A DOWN in 'aldosterone-producing adenoma' vs 'normal'
NID1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MIS18A DOWN in 'aldosterone-producing adenoma' vs 'normal'
IL1R1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PTGS2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
C3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
APOC1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HK2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
COLEC11 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ARHGAP36 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RTN3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ITGA1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GPM6A DOWN in 'aldosterone-producing adenoma' vs 'normal'
RNF149 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GUF1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HS6ST3 UP in 'aldosterone-producing adenoma' vs 'normal'
C8orf4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
EBP DOWN in 'aldosterone-producing adenoma' vs 'normal'
RP11-489E7.4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ABCB10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AREG DOWN in 'aldosterone-producing adenoma' vs 'normal'
TMOD1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RPS20 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AFF4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NIPSNAP3A DOWN in 'aldosterone-producing adenoma' vs 'normal'
KLHL2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SCARB2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MITD1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
AZI2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
C16orf72 DOWN in 'aldosterone-producing adenoma' vs 'normal'
EZR DOWN in 'aldosterone-producing adenoma' vs 'normal'
SSTR5-AS1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ZNF608 DOWN in 'aldosterone-producing adenoma' vs 'normal'
LYRM7 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DIDO1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CNKSR3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
GLIPR2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PDGFC DOWN in 'aldosterone-producing adenoma' vs 'normal'
IMPA2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
N4BP2L1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PLEKHA5 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PTGER4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PRDX3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ARFGEF2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RNF14 DOWN in 'aldosterone-producing adenoma' vs 'normal'
DERA DOWN in 'aldosterone-producing adenoma' vs 'normal'
GSTA4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MPHOSPH8 DOWN in 'aldosterone-producing adenoma' vs 'normal'
SPRED1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PNMT DOWN in 'aldosterone-producing adenoma' vs 'normal'
BHLHE40 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PRUNE2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CSGALNACT1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KIAA1024 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CAMKK2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PCDHB14 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MBNL1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
KLF10 DOWN in 'aldosterone-producing adenoma' vs 'normal'
REPS2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
COL14A1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CFI DOWN in 'aldosterone-producing adenoma' vs 'normal'
ADNP DOWN in 'aldosterone-producing adenoma' vs 'normal'
PROX1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
HRSP12 DOWN in 'aldosterone-producing adenoma' vs 'normal'
ST8SIA1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
USP48 DOWN in 'aldosterone-producing adenoma' vs 'normal'
MTMR4 UP in 'aldosterone-producing adenoma' vs 'normal'
FAM149B1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
EIF4G1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
TMX1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RIN3 DOWN in 'aldosterone-producing adenoma' vs 'normal'
RFPL1S DOWN in 'aldosterone-producing adenoma' vs 'normal'
NRP2 DOWN in 'aldosterone-producing adenoma' vs 'normal'
PTPLAD1 DOWN in 'aldosterone-producing adenoma' vs 'normal'
CCL4 DOWN in 'aldosterone-producing adenoma' vs 'normal'
NCOA1 DOWN in 'aldosterone-producing adenoma' vs 'normal'