Zbtb16 UP in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Gm6483 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Mpp7 UP in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Zbtb16 UP in 'repeated morphine injection' vs 'saline injection' in 'SWR/J'
Per2 UP in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Zbtb16 UP in 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
Cdkn1a UP in 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
Atp8a1 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Gsk3b DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Zbtb16 UP in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Hspa1b UP in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Ogt DOWN in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Rorb DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Smim3 UP in 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
Sgk1 UP in 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
Matn2 UP in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Akap9 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Zbtb16 UP in 'single morphine injection' vs 'saline injection' in '129P3/J'
Analysis of 'repeated morphine injection' vs 'saline injection' in '129P3/J'
Analysis of 'repeated morphine injection' vs 'saline injection' in 'SWR/J'
(Factor value) CLINICAL_INFORMATION/repeated morphine injection
Kcnab2 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Prss23 UP in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Arhgap32 DOWN in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Kcnab2 DOWN in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Analysis of 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
A330076H08Rik DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Herc2 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Sema7a DOWN in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Tmem158 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Arrdc2 UP in 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
Cpsf6 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Ctla2a UP in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Dfna5 DOWN in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Analysis of 'single morphine injection' vs 'saline injection' in 'SWR/J'
(Factor value) CLINICAL_INFORMATION/single morphine injection
Tmem158 DOWN in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Plin4 UP in 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
Chronic opiate use produces molecular and cellular adaptations in the nervous system, leading to tolerance, physical dependence and addiction. Genome-wide comparison of morphine-induced changes in brain transcription of mouse strains with different opioid-related phenotypes provides an opportunity to discover the relationship between gene expression and behavioral response to the drug. Experiment Overall Design: Microarray experiment was designed to determine the impact of genetic background on the transcriptional effects of morphine in the striatum. The effects of single (20 mg/kg, s.c.) and repeated morphine administration (10-40 mg/kg, 3 times daily for 5 days) were analyzed in four inbred mouse strains (129P3/J. DBA/2J, C57BL/6J, SWR/J). Twelve experimental groups were compared. Control animals received injections of saline. Three independent biological replicates of the microarray were prepared for each experimental group. For each array, independent pools of total RNA from three animals were prepared.
Spp1 UP in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
C130071C03Rik DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Plin4 UP in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Luc7l2 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
(Factor value) CLINICAL_INFORMATION/saline injection
Tsc22d3 UP in 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
Vapb DOWN in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Taok1 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Analysis of 'single morphine injection' vs 'saline injection' in '129P3/J'
Pmaip1 UP in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Dfna5 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Chic1 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Pdk4 UP in 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
Tm6sf1 UP in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Xdh UP in 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
Plin4 UP in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Zfp871 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Hspa1a UP in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Kcnma1 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Sfpq DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Vapb DOWN in 'repeated morphine injection' vs 'saline injection' in '129P3/J'
Tma16 UP in 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
Rab6b DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Fut9 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Analysis of 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Arl15 DOWN in 'single morphine injection' vs 'saline injection' in 'SWR/J'
Slc2a1 UP in 'single morphine injection' vs 'saline injection' in 'C57BL/6J'
Rhpn2 UP in 'single morphine injection' vs 'saline injection' in 'DBA/2J'
Arhgap32 DOWN in 'single morphine injection' vs 'saline injection' in 'DBA/2J'