CCNE2 DOWN in 'Streptococcus gordonii' vs 'uninfected'
(Assay) HIGK cells infected with Fusobacterium nucleatum, biological rep2
HIGK cells infected with Fusobacterium nucleatum, biological rep2
SOWAHC DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
LRRFIP1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
HSPH1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
NFIL3 UP in 'Fusobacterium nucleatum' vs 'uninfected'
CALD1 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
DUSP4 DOWN in 'Streptococcus gordonii' vs 'uninfected'
RCOR1 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
(Assay) HIGK cells infected with Fusobacterium nucleatum, biological rep1
HIGK cells infected with Fusobacterium nucleatum, biological rep1
HNRNPA3 DOWN in 'Streptococcus gordonii' vs 'uninfected'
MYC DOWN in 'Streptococcus gordonii' vs 'uninfected'
PFKFB3 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
SCAF8 DOWN in 'Streptococcus gordonii' vs 'uninfected'
GADD45B UP in 'Streptococcus gordonii' vs 'uninfected'
SS18L1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
FN1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
NET1 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
DUSP4 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
AKAP12 DOWN in 'Streptococcus gordonii' vs 'uninfected'
DICER1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
FOS UP in 'Streptococcus gordonii' vs 'uninfected'
SLC30A1 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
HIC2 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
IL6ST DOWN in 'Streptococcus gordonii' vs 'uninfected'
OSBPL8 DOWN in 'Streptococcus gordonii' vs 'uninfected'
GCH1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
Transcriptional profiling was utilized to define the biological pathways of gingival epithelial cells modulated by co-culture with the oral commensal S. gordonii and the opportunistic commensal F. nucleatum. We used microarrays to detail the global programme of gene expression underlying infection and identified distinct classes of up- and down-regulated genes during this process. Experiment Overall Design: Gingival epithelial HIGK cells were sham infected (CTRL) and infected with either the oral commensal S. gordonii (Sg) or the opportunistic commensal F. nucleatum (Fn). These samples were hybridized to Affymetrix microarrays. Understanding how host cells have adapted to commensals, and how barrier cells respond to limit their impact, provides a mechanistic biological basis of health in the mixed bacterial-human ecosystem of the oral cavity.
(Assay) HIGK cells infected with Streptococcus gordonii, biological rep4
HIGK cells infected with Streptococcus gordonii, biological rep4
(Assay) Sham infected HIGK cells, biological rep3
Sham infected HIGK cells, biological rep3
EGR1 UP in 'Fusobacterium nucleatum' vs 'uninfected'
DKK1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
MAT2A DOWN in 'Streptococcus gordonii' vs 'uninfected'
HSPH1 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
CD44 DOWN in 'Streptococcus gordonii' vs 'uninfected'
SLC30A1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
Analysis of 'Fusobacterium nucleatum' vs 'uninfected'
RGS2 UP in 'Fusobacterium nucleatum' vs 'uninfected'
ID1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
RHOB DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
KLF10 DOWN in 'Streptococcus gordonii' vs 'uninfected'
KDM2A DOWN in 'Streptococcus gordonii' vs 'uninfected'
TDG DOWN in 'Streptococcus gordonii' vs 'uninfected'
(Factor value) INFECT/Streptococcus gordonii
ERBB2IP DOWN in 'Streptococcus gordonii' vs 'uninfected'
VEGFA DOWN in 'Streptococcus gordonii' vs 'uninfected'
FST DOWN in 'Streptococcus gordonii' vs 'uninfected'
TIPARP DOWN in 'Streptococcus gordonii' vs 'uninfected'
(Assay) Sham infected HIGK cells, biological rep2
Sham infected HIGK cells, biological rep2
ZNF12 DOWN in 'Streptococcus gordonii' vs 'uninfected'
FST DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
DUSP7 DOWN in 'Streptococcus gordonii' vs 'uninfected'
SNAI2 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
GADD45B UP in 'Fusobacterium nucleatum' vs 'uninfected'
DNAJA1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
SNAI2 DOWN in 'Streptococcus gordonii' vs 'uninfected'
MIR22HG DOWN in 'Streptococcus gordonii' vs 'uninfected'
LIF DOWN in 'Streptococcus gordonii' vs 'uninfected'
(Assay) HIGK cells infected with Fusobacterium nucleatum, biological rep3
HIGK cells infected with Fusobacterium nucleatum, biological rep3
NET1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
EGR1 UP in 'Streptococcus gordonii' vs 'uninfected'
SERPINB2 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
ZC3HAV1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
PFKFB3 DOWN in 'Streptococcus gordonii' vs 'uninfected'
PMAIP1 UP in 'Fusobacterium nucleatum' vs 'uninfected'
YTHDF3 DOWN in 'Streptococcus gordonii' vs 'uninfected'
RCOR1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
LIF DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
CD44 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
Analysis of 'Streptococcus gordonii' vs 'uninfected'
CHAC1 UP in 'Streptococcus gordonii' vs 'uninfected'
PIK3C2A DOWN in 'Streptococcus gordonii' vs 'uninfected'
ACSL3 DOWN in 'Streptococcus gordonii' vs 'uninfected'
CALD1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
FOS UP in 'Fusobacterium nucleatum' vs 'uninfected'
(Assay) HIGK cells infected with Streptococcus gordonii, biological rep2
HIGK cells infected with Streptococcus gordonii, biological rep2
(Assay) Sham infected HIGK cells, biological rep4
Sham infected HIGK cells, biological rep4
(Factor value) INFECT/Fusobacterium nucleatum
RBM15 DOWN in 'Streptococcus gordonii' vs 'uninfected'
FERMT2 DOWN in 'Streptococcus gordonii' vs 'uninfected'
(Assay) HIGK cells infected with Streptococcus gordonii, biological rep1
HIGK cells infected with Streptococcus gordonii, biological rep1
SLC7A11 DOWN in 'Streptococcus gordonii' vs 'uninfected'
RHOB DOWN in 'Streptococcus gordonii' vs 'uninfected'
SERPINB2 DOWN in 'Streptococcus gordonii' vs 'uninfected'
PNN DOWN in 'Streptococcus gordonii' vs 'uninfected'
CHSY1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
NRIP1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
BCAR3 DOWN in 'Streptococcus gordonii' vs 'uninfected'
LRRFIP1 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
(Assay) HIGK cells infected with Fusobacterium nucleatum, biological rep4
HIGK cells infected with Fusobacterium nucleatum, biological rep4
SS18L1 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
PTHLH DOWN in 'Streptococcus gordonii' vs 'uninfected'
SLC20A1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
COPA DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
(Assay) HIGK cells infected with Streptococcus gordonii, biological rep3
HIGK cells infected with Streptococcus gordonii, biological rep3
FN1 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
PLOD2 DOWN in 'Streptococcus gordonii' vs 'uninfected'
TUFT1 DOWN in 'Streptococcus gordonii' vs 'uninfected'
(Assay) Sham infected HIGK cells, biological rep1
Sham infected HIGK cells, biological rep1
SLC20A1 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
PALLD DOWN in 'Streptococcus gordonii' vs 'uninfected'
AKAP12 DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
PTHLH DOWN in 'Fusobacterium nucleatum' vs 'uninfected'
SLC5A3 DOWN in 'Streptococcus gordonii' vs 'uninfected'
SLC25A32 DOWN in 'Streptococcus gordonii' vs 'uninfected'
CREBBP DOWN in 'Streptococcus gordonii' vs 'uninfected'
MARCH6 DOWN in 'Streptococcus gordonii' vs 'uninfected'
NUP98 DOWN in 'Streptococcus gordonii' vs 'uninfected'