Lum UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
2310061I04Rik DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Mlf1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
(Assay) Heart, MAT1 control, 2 wk, sample 3
Alad DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Efnb3 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Nfil3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Reln UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Eln UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Txnrd2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Egr2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
R74862 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Nr1d2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Adam19 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Fgl2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Fhl1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Mthfr UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Gja1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Fhl2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Hbegf UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tuba1a UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Atp13a3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Actn4 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tuba4a DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col6a1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
(Assay) Heart, MAT1 control, 4 wk, sample 1
Ank1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ppap2a UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Car14 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Msrb1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Lpl DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Acaa2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Naalad2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tnfaip8 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Acta1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '2 week'
(Assay) Heart, MAT1 control, 2 wk, sample 2
Uck2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Fkbp4 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Frzb UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Slc25a20 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Adcy7 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Csrp1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Cd24a UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Mfap5 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Mfge8 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tmem45a UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Myl1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Thrsp DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Plagl1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Eci1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Nppa UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Analysis of 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Entpd5 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Coq7 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Atf3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ndufa6 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Pmp22 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Cdkn1a UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
S100a13 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Fn1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Abcc9 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Anxa1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Gdf15 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Wls UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Wbp5 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
(Assay) Heart, MAT1 control, 4 wk, sample 2
Lpin1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Iigp1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Gsta4 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Dap UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Itih5 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Bckdhb DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Prkab1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Dio2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
(Sample) genotype/alphaMHC-Cre+/0;MAT1F/F
Serpine2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Rbp1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ech1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col4a1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Mid1ip1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Kif1c DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Wwtr1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Phkg1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Cpxm2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tnni3 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Lamc2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Pfkp UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Bckdha DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Xirp1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Bgn UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Bax UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Psmd8 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Dbt DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Rtn4 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ivd DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Rgs2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Plbd1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Snrpa1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ces1d DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Fndc1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
(Assay) Heart, MAT1 control, 4 wk, sample 3
Itgav UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Serpinf1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Vcan UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Analysis of 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '2 week'
Idh2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tcea3 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tmem167 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Lox UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Pdlim3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tspo UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Clip4 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col1a2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tspan9 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
(Assay) Heart, MAT1 control, 2 wk, sample 1
Trim47 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Postn UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Actn1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
(Sample) genotype/alphaMHC-Cre+/0;MAT1F/+
Cnn1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Pdlim7 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Adam9 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col3a1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Litaf UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tnc UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Nnt DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col1a1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Myom2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Hrc DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Rcan1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Kdelr3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Nid2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Penk DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
(Factor value) GENOTYPE/alphaMHC-Cre+/0;MAT1F/+
Hopx DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Nppb UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Hspa1a UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ank1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ddb1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ndufs1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
H2-Ea-ps DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Hccs DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ift81 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col5a1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Enpp1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Cmbl DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ptgds DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Crip2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
S100a10 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Gsto1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Cyth3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ndufb10 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Large UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ext1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col5a2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Acta2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Msn UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Pfkm DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ell2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Etfdh DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
The Cdk7/cyclin H/menage-a-trois 1 (MAT1) heterotrimer has proposed functions in transcription as the kinase component of basal transcription factor TFIIH and is activated in adult hearts by hypertrophic pathways. Using cardiac-specific Cre, we ablated MAT1 in myocardium. Despite reduced Cdk7 activity, MAT1-deficient hearts grew normally. However, fatal heart failure ensued at 6-8 weeks. By microarray profiling, quantitative RT-PCR, and Western blotting at 4 weeks, genes for energy metabolism were found to be suppressed selectively, including targets of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1). Cardiac metabolic defects were substantiated in isolated perfused hearts and isolated mitochondria. In culture, deleting MAT1 with Cre disrupted PGC-1 function: PGC-1ÃÂÃÂ± failed to activate PGC-1-responsive promoters and nuclear receptors, GAL4-PGC-1ÃÂÃÂ± was functionally defective, and PGC-1ÃÂÃÂ² likewise was deficient. PGC-1 was shown to interact with MAT1 and Cdk7, in co-precipitation assays. Thus, we demonstrate an unforeseen essential role for MAT1 in operation of the PGC-1 family of co-activators. Experiment Overall Design: MAT1F/F mice (Korsisaari et al., 2002) were bred with mice expressing Cre recombinase under the control of the cardiomyocyte-specific ÃÂÃÂ±-myosin heavy chain (ÃÂÃÂ±MHC) promoter (Gaussin et al., 2002a) and back-bred to MAT1F/F mice to generate the cardiac-specific knockout (ÃÂÃÂ±MHC-Cre+/0; MAT1F/F; CKO; Fig. 1A, B). Control mice were ÃÂÃÂ±MHC-Cre+/0; MAT1F/+ littermates, differing by the presence of one wild-type MAT1 allele, and excluding Cre-mediated toxicity as a basis for phenotypic disparity. Cardiac RNA samples were analyze at 2 or 4 weeks of age (N = 3-5 for each condition tested.
Echs1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Meox1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Enah UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Slc25a11 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Lmna UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Uchl1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Pcolce UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Gpx3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Gmnn DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Gyg UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Rab31 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Pfn2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Dkk3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col14a1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col15a1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ppic UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ryr2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tgfbi UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Synpo UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Kctd12 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Cx3cl1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Acsl1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Aldh9a1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Lrp1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Art1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Fstl1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Npc1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Il15 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
2610002J02Rik UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tubb6 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ctsz UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Atp6v1h UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Mgp UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ggct DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Fbn1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Anxa2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Rhoc UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Pah DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Cav3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Atp2a2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Fzd2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tpm2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Hsdl2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Lgals4 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Spag7 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tgfb2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Phyh DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Coq9 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Sparc UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Phlda3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
D10Jhu81e DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col8a1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Slc27a1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Peg3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Aqp4 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ugdh UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ivns1abp DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Gstk1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Psme1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col6a3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Tgfb3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Prss23 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Etfa DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Serpinb6a UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ptgis UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Adssl1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ctgf UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Ltbp2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
(Factor value) GENOTYPE/alphaMHC-Cre+/0;MAT1F/F
Mfap2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Etfb DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Emp1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Thbs1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Atp1a2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Hspa1b UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Cpt2 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Slc4a3 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Dpysl3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Sgca DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col4a2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Crlf1 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Pqlc3 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Herpud1 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Sdha DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Gdap10 DOWN in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Itm2a UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Col6a2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'
Fbln2 UP in 'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'