Eln DOWN in '18 month' vs '2 month' in 'DBA/2J'
Ikzf3 UP in '18 month' vs '2 month' in 'C57BL/6J'
Myrip UP in '18 month' vs '2 month' in 'DBA/2J'
Fam101a DOWN in '18 month' vs '2 month' in 'DBA/2J'
Fbn1 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Loxl1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Phex DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Scn3a DOWN in '18 month' vs '2 month' in 'DBA/2J'
Ccl8 UP in '18 month' vs '2 month' in 'DBA/2J'
Gsta3 UP in '18 month' vs '2 month' in 'DBA/2J'
Pisd-ps1 UP in '18 month' vs '2 month' in 'C57BL/6J'
Slc6a20a UP in '18 month' vs '2 month' in 'C57BL/6J'
Col3a1 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Anxa8 UP in '18 month' vs '2 month' in 'DBA/2J'
Cd22 UP in '18 month' vs '2 month' in 'C57BL/6J'
Gp1bb UP in '18 month' vs '2 month' in 'C57BL/6J'
Ddc DOWN in '18 month' vs '2 month' in 'DBA/2J'
Mrap2 UP in '18 month' vs '2 month' in 'DBA/2J'
Ighg2b UP in '18 month' vs '2 month' in 'C57BL/6J'
Hhip DOWN in '18 month' vs '2 month' in 'DBA/2J'
Plat UP in '18 month' vs '2 month' in 'DBA/2J'
Col5a2 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Dmxl2 UP in '18 month' vs '2 month' in 'DBA/2J'
Ckm UP in '18 month' vs '2 month' in 'DBA/2J'
Igkc UP in '18 month' vs '2 month' in 'C57BL/6J'
Mzb1 UP in '18 month' vs '2 month' in 'C57BL/6J'
Pla2g7 UP in '18 month' vs '2 month' in 'DBA/2J'
Ighg1 UP in '18 month' vs '2 month' in 'C57BL/6J'
Col5a1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Zfp711 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Iglc2 UP in '18 month' vs '2 month' in 'C57BL/6J'
Egr1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Klhl41 UP in '18 month' vs '2 month' in 'DBA/2J'
Igfbp3 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Igf1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Wisp1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Fetub UP in '18 month' vs '2 month' in 'DBA/2J'
Pcdh18 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Mmp9 UP in '18 month' vs '2 month' in 'DBA/2J'
Rdh12 UP in '18 month' vs '2 month' in 'DBA/2J'
Fam107a UP in '18 month' vs '2 month' in 'DBA/2J'
Eno3 UP in '18 month' vs '2 month' in 'DBA/2J'
Tlr13 UP in '18 month' vs '2 month' in 'DBA/2J'
Slc6a20a UP in '18 month' vs '2 month' in 'DBA/2J'
H2-Ob UP in '18 month' vs '2 month' in 'C57BL/6J'
Cxcr6 UP in '18 month' vs '2 month' in 'C57BL/6J'
Bst1 UP in '18 month' vs '2 month' in 'DBA/2J'
Prdm8 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Dnajb1 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Tet1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Ccr6 UP in '18 month' vs '2 month' in 'C57BL/6J'
Egln3 UP in '18 month' vs '2 month' in 'DBA/2J'
Col1a1 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Klhl29 UP in '18 month' vs '2 month' in 'DBA/2J'
Evl DOWN in '18 month' vs '2 month' in 'DBA/2J'
Cd79b UP in '18 month' vs '2 month' in 'C57BL/6J'
Mmp8 UP in '18 month' vs '2 month' in 'DBA/2J'
Mfap4 DOWN in '18 month' vs '2 month' in 'DBA/2J'
F13a1 UP in '18 month' vs '2 month' in 'DBA/2J'
Scn3b DOWN in '18 month' vs '2 month' in 'DBA/2J'
Col1a1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Gcnt2 UP in '18 month' vs '2 month' in 'DBA/2J'
Col5a2 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Mcm6 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Serpina3n UP in '18 month' vs '2 month' in 'DBA/2J'
Efhd1 UP in '18 month' vs '2 month' in 'DBA/2J'
Cd300lb UP in '18 month' vs '2 month' in 'DBA/2J'
Ltf UP in '18 month' vs '2 month' in 'DBA/2J'
Igha UP in '18 month' vs '2 month' in 'C57BL/6J'
Il1b UP in '18 month' vs '2 month' in 'DBA/2J'
Fscn1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Thy1 UP in '18 month' vs '2 month' in 'C57BL/6J'
Ighm UP in '18 month' vs '2 month' in 'DBA/2J'
Mmp12 UP in '18 month' vs '2 month' in 'C57BL/6J'
Igkv6-15 UP in '18 month' vs '2 month' in 'C57BL/6J'
Cd163 UP in '18 month' vs '2 month' in 'DBA/2J'
Igha UP in '18 month' vs '2 month' in 'DBA/2J'
Cttnbp2 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Esm1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Fkbp5 UP in '18 month' vs '2 month' in 'DBA/2J'
Hspa1b DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Stfa2l1 UP in '18 month' vs '2 month' in 'DBA/2J'
Igkv14-111 UP in '18 month' vs '2 month' in 'C57BL/6J'
Asb5 UP in '18 month' vs '2 month' in 'DBA/2J'
Slc6a2 UP in '18 month' vs '2 month' in 'DBA/2J'
Rad51ap1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Pcdh17 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Gem DOWN in '18 month' vs '2 month' in 'DBA/2J'
Cyp1a1 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Npr3 UP in '18 month' vs '2 month' in 'DBA/2J'
Dsc2 UP in '18 month' vs '2 month' in 'DBA/2J'
Col3a1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Adamts2 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Slfn1 UP in '18 month' vs '2 month' in 'DBA/2J'
Bex2 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Tmem132c DOWN in '18 month' vs '2 month' in 'DBA/2J'
BC048546 UP in '18 month' vs '2 month' in 'C57BL/6J'
Tdo2 UP in '18 month' vs '2 month' in 'DBA/2J'
Fbn1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Ms4a6d UP in '18 month' vs '2 month' in 'DBA/2J'
Prtn3 UP in '18 month' vs '2 month' in 'DBA/2J'
Nrep DOWN in '18 month' vs '2 month' in 'DBA/2J'
Csf3r UP in '18 month' vs '2 month' in 'DBA/2J'
Ptprd DOWN in '18 month' vs '2 month' in 'DBA/2J'
We hypothesize that gene expression in the aging lungs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes.re specifically, (1) Aging DBA/2J mice compared to aging C57BL/6 mice are known to be accelerated in their lung physiology andrphometry; (2) C57BL/6J are known to have longer natural longevity than DBA/2J mice. In order to test these hypotheses at the gene expression level, we utilized microarray analysis to examine transcriptional differences between aging lungs of both strains of mice. Experiment Overall Design: This study utilizes microarray analysis to test these hypotheses. Three sets of lungs were harvested from both strains at each time point (C57BL/6J: 2, 18, AND 26s; DBA/2J: 2 and 18s). RNA was isolated and used for global gene expression profiling (Affymetrixuse 430 2.0 array). Statistically significant gene expression was determined as a minimum 6 counts of 9 pairwise comparisons, minimum 1.5-fold change, and p < 0.05. Further, Absolute | FC - FC SEM | >= 1.5.
Emilin2 UP in '18 month' vs '2 month' in 'DBA/2J'
Analysis of '18 month' vs '2 month' in 'C57BL/6J'
Alox5ap UP in '18 month' vs '2 month' in 'DBA/2J'
Cyp4f18 UP in '18 month' vs '2 month' in 'DBA/2J'
Serpinb2 UP in '18 month' vs '2 month' in 'DBA/2J'
Il7r UP in '18 month' vs '2 month' in 'C57BL/6J'
Ighg2c UP in '18 month' vs '2 month' in 'C57BL/6J'
Col1a2 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Prmt8 UP in '18 month' vs '2 month' in 'DBA/2J'
Il1f9 UP in '18 month' vs '2 month' in 'DBA/2J'
Ighm UP in '18 month' vs '2 month' in 'C57BL/6J'
RP23-76P9.1 UP in '18 month' vs '2 month' in 'C57BL/6J'
Mmp2 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Fmo3 UP in '18 month' vs '2 month' in 'DBA/2J'
Slc2a3 UP in '18 month' vs '2 month' in 'DBA/2J'
Igj UP in '18 month' vs '2 month' in 'C57BL/6J'
Hspa1a DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Bex1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Cd300lf UP in '18 month' vs '2 month' in 'DBA/2J'
Myl3 UP in '18 month' vs '2 month' in 'DBA/2J'
Wfdc17 UP in '18 month' vs '2 month' in 'DBA/2J'
Cxcl13 UP in '18 month' vs '2 month' in 'C57BL/6J'
AB124611 UP in '18 month' vs '2 month' in 'DBA/2J'
Trem1 UP in '18 month' vs '2 month' in 'DBA/2J'
Nr4a1 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Pcdh12 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Cd79a UP in '18 month' vs '2 month' in 'C57BL/6J'
S100a9 UP in '18 month' vs '2 month' in 'DBA/2J'
Adamts2 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Adh7 UP in '18 month' vs '2 month' in 'DBA/2J'
Zbtb16 UP in '18 month' vs '2 month' in 'DBA/2J'
Tril DOWN in '18 month' vs '2 month' in 'DBA/2J'
Pirb UP in '18 month' vs '2 month' in 'DBA/2J'
Ccr1 UP in '18 month' vs '2 month' in 'DBA/2J'
Clec4d UP in '18 month' vs '2 month' in 'DBA/2J'
Arg2 UP in '18 month' vs '2 month' in 'DBA/2J'
Prune2 UP in '18 month' vs '2 month' in 'DBA/2J'
Nrcam DOWN in '18 month' vs '2 month' in 'DBA/2J'
Igsf6 UP in '18 month' vs '2 month' in 'DBA/2J'
Phex DOWN in '18 month' vs '2 month' in 'DBA/2J'
Gm8369 UP in '18 month' vs '2 month' in 'C57BL/6J'
Col6a3 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Map3k6 UP in '18 month' vs '2 month' in 'DBA/2J'
Pou2af1 UP in '18 month' vs '2 month' in 'C57BL/6J'
Trac UP in '18 month' vs '2 month' in 'C57BL/6J'
Il1r2 UP in '18 month' vs '2 month' in 'DBA/2J'
Clca1 UP in '18 month' vs '2 month' in 'DBA/2J'
Klra17 UP in '18 month' vs '2 month' in 'DBA/2J'
Nfe2 UP in '18 month' vs '2 month' in 'DBA/2J'
Ms4a1 UP in '18 month' vs '2 month' in 'C57BL/6J'
Gda UP in '18 month' vs '2 month' in 'DBA/2J'
Aplnr DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Mxd1 UP in '18 month' vs '2 month' in 'DBA/2J'
Tnc DOWN in '18 month' vs '2 month' in 'DBA/2J'
Igkv3-12 UP in '18 month' vs '2 month' in 'C57BL/6J'
Npnt DOWN in '18 month' vs '2 month' in 'DBA/2J'
Lrg1 UP in '18 month' vs '2 month' in 'DBA/2J'
Slfn4 UP in '18 month' vs '2 month' in 'DBA/2J'
Itgam UP in '18 month' vs '2 month' in 'DBA/2J'
Pcdh12 DOWN in '18 month' vs '2 month' in 'DBA/2J'
S100a8 UP in '18 month' vs '2 month' in 'DBA/2J'
Stk33 UP in '18 month' vs '2 month' in 'DBA/2J'
Heph DOWN in '18 month' vs '2 month' in 'DBA/2J'
Cd177 UP in '18 month' vs '2 month' in 'DBA/2J'
Zfand4 UP in '18 month' vs '2 month' in 'DBA/2J'
Penk UP in '18 month' vs '2 month' in 'DBA/2J'
Iglv1 UP in '18 month' vs '2 month' in 'C57BL/6J'
Afp UP in '18 month' vs '2 month' in 'DBA/2J'
Analysis of '18 month' vs '2 month' in 'DBA/2J'
Slc22a3 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Sult1d1 UP in '18 month' vs '2 month' in 'DBA/2J'
Cd3g UP in '18 month' vs '2 month' in 'C57BL/6J'
Chst2 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Clec4e UP in '18 month' vs '2 month' in 'DBA/2J'
RP23-76P9.1 UP in '18 month' vs '2 month' in 'DBA/2J'
Spon2 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Fcgr3 UP in '18 month' vs '2 month' in 'DBA/2J'
Fam101a DOWN in '18 month' vs '2 month' in 'C57BL/6J'
C5ar1 UP in '18 month' vs '2 month' in 'DBA/2J'
Serpina3m UP in '18 month' vs '2 month' in 'DBA/2J'
Selp UP in '18 month' vs '2 month' in 'DBA/2J'
Col1a2 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Peg3 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Apobec2 UP in '18 month' vs '2 month' in 'DBA/2J'
Olfm4 UP in '18 month' vs '2 month' in 'DBA/2J'
Gfra2 DOWN in '18 month' vs '2 month' in 'DBA/2J'
Cd177 UP in '18 month' vs '2 month' in 'C57BL/6J'
Rab3c UP in '18 month' vs '2 month' in 'DBA/2J'
Ccr2 UP in '18 month' vs '2 month' in 'C57BL/6J'
Ecm2 DOWN in '18 month' vs '2 month' in 'C57BL/6J'
Iigp1 DOWN in '18 month' vs '2 month' in 'DBA/2J'