VEPH1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
VEPH1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
HIST1H4H UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
HIST1H4H UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
RP11-665E10.5 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
RP11-665E10.5 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types1. However, loss-of-function mutations in PRC2 components occur in a subset of haematopoietic malignancies, sug- gesting that this complex plays a dichotomous and poorly understood role in cancer2,3. Here we provide genomic, cellular, and mouse mod- elling data demonstrating that the polycomb group gene SUZ12 func- tions as tumour suppressor in PNS tumours, high-grade gliomas and melanomas by cooperating with mutations in NF1. NF1 encodes a Ras GTPase-activating protein (RasGAP) and its loss drives cancer by activating Ras4. We show that SUZ12 loss potentiates the effects of NF1 mutations by amplifying Ras-driven transcription through effects on chromatin. Importantly, however, SUZ12 inactivation also triggers an epigenetic switch that sensitizes these cancers to bromodomain inhib- itors. Collectively, these studies not only reveal an unexpected con- nection between the PRC2 complex, NF1 and Ras, but also identify a promising epigenetic-based therapeutic strategy that may be exploited for a variety of cancers. 9 samples in triplicates, 3x LacZ control, 3x SUZ12 over expression, 3x JQ1 treatment
C15orf54 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
C15orf54 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
FST DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
FST DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
SLC34A2 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
SLC34A2 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
CCDC80 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
CCDC80 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
SCG5 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
SCG5 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
HECW2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
HECW2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ELOVL6 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
ELOVL6 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
TM6SF1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
TM6SF1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
FGF1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
FGF1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
FGF5 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
FGF5 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
SERPINB7 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
SERPINB7 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
ATP8A1 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ATP8A1 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
IFI44 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
IFI44 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
RFPL4AL1 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
RFPL4AL1 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
KIAA1324L UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
KIAA1324L UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
IFI44L DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
IFI44L DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
S100A2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
S100A2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
Analysis of 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
Analysis of 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
GCH1 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
GCH1 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
RASGRP3 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
RASGRP3 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
SYNE1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
SYNE1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
CD274 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
CD274 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PARP9 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PARP9 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
(Factor value) GENOTYPE/heterozygous loss and Tyr430 mutation in SUZ12
heterozygous loss and Tyr430 mutation in SUZ12
PRDM1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PRDM1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
TRIM51BP UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
TRIM51BP UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PARP14 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PARP14 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
CCDC84 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
CCDC84 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PSTPIP2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PSTPIP2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
SULF1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
SULF1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
LIFR UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
LIFR UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
GLT8D2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
GLT8D2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
HERC6 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
HERC6 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
TNC DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
TNC DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PAPPA-AS1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PAPPA-AS1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ANGPT2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ANGPT2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
(Sample) cell type/malignant peripheral nerve sheath tumour cell
malignant peripheral nerve sheath tumour cell
DHRS2 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
DHRS2 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
APOBEC3B DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
APOBEC3B DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ZSCAN4 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
ZSCAN4 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
IFIH1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
IFIH1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
AK5 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
AK5 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PTPRB DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PTPRB DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
(Sample) genotype/NF1 region (incl. SUZ12) heterozygous microdeletion and Tyr430 mutation in SUZ12
NF1 region (incl. SUZ12) heterozygous microdeletion and Tyr430 mutation in SUZ12
ADAMTS6 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ADAMTS6 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
RP11-432M8.8 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
RP11-432M8.8 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
TM4SF18 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
TM4SF18 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
KLHL24 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
KLHL24 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PDE1C DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PDE1C DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PDCD1LG2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PDCD1LG2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
XAF1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
XAF1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
AOX1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
AOX1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
LY6K DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
LY6K DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
TMEM47 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
TMEM47 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
BAI3 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
BAI3 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
SAMD9L DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
SAMD9L DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
SERPINB2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
SERPINB2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
HAS2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
HAS2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
MPP4 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
MPP4 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
OAS1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
OAS1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
LCP1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
LCP1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
FAP DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
FAP DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
SLC14A1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
SLC14A1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
CXCL12 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
CXCL12 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
RNVU1-15 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
RNVU1-15 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PSG4 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PSG4 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
(Factor value) COMPOUND/JQ1 bromodomain inhibitor
TENM2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
TENM2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PNP UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PNP UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
RFX8 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
RFX8 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
ANGPT1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ANGPT1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
IL1A DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
IL1A DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
(Sample) genotype/NF1 region (incl. SUZ12) heterozygous microdeletion and Tyr430 mutation in SUZ12 with re-expressed SUZ12
NF1 region (incl. SUZ12) heterozygous microdeletion and Tyr430 mutation in SUZ12 with re-expressed SUZ12
(Factor value) GENOTYPE/heterozygous loss and Tyr430 mutation in SUZ12 with re-expressed SUZ12
heterozygous loss and Tyr430 mutation in SUZ12 with re-expressed SUZ12
TRERF1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
TRERF1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
IL1B DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
IL1B DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
GATM UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
GATM UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PSG9 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PSG9 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
FAM90A27P UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
FAM90A27P UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
NEFM UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
NEFM UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
TGFB2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
TGFB2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
RHOJ DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
RHOJ DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
BAMBI UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
BAMBI UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PRRX1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PRRX1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
TMEM244 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
TMEM244 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
CCL2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
CCL2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
IL7R DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
IL7R DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
RBBP6 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
RBBP6 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
KCNK2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
KCNK2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
IGFBP5 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
IGFBP5 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
MAMDC2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
MAMDC2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
RP11-1002K11.1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
RP11-1002K11.1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
HIST2H4A UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
HIST2H4A UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
GPR126 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
GPR126 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
SESN3 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
SESN3 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
ANXA3 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
ANXA3 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
NOX4 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
NOX4 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
PRAMEF1 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
PRAMEF1 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
LPHN3 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
LPHN3 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
NRP2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
NRP2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ATP8B1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ATP8B1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
IL6 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
IL6 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
CNN2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
CNN2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
LPXN DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
LPXN DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
CDK15 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
CDK15 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ALDH1A1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
ALDH1A1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ANO1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
ANO1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'