PSG4
type: EnsemblDatabaseReference

TM4SF18
type: EnsemblDatabaseReference

VEPH1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: VEPH1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.3
p value: 0.00456190431469736
refers to: VEPH1
refers to: 8091678
t statistic: -8.54251032444361

SESN3
type: EnsemblDatabaseReference

HIST1H4H UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: IncreasedDifferentialExpressionRatio
label: HIST1H4H UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: 1.1
p value: 0.0190710191867562
refers to: HIST1H4H
refers to: 8124448
t statistic: 5.37268250315106

CDK15
type: EnsemblDatabaseReference

CD274
type: EnsemblDatabaseReference

FAM90A27P
type: EnsemblDatabaseReference

8073062
type: EFO_0005072
part of: A-AFFY-141

8112342
type: EFO_0005072
part of: A-AFFY-141

PRDM1
type: EnsemblDatabaseReference

SERPINB2
type: EnsemblDatabaseReference

8056285
type: EFO_0005072
part of: A-AFFY-141

RP11-665E10.5 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: RP11-665E10.5 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.0
p value: 6.27352599659583E-4
refers to: RP11-665E10.5
refers to: 8055494
t statistic: -17.2897786683498

7895105
type: EFO_0005072
part of: A-AFFY-141

E-GEOD-62500
type: microarray 1colour mrna differential
RO_0002162: Homo sapiens
description: The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types1. However, loss-of-function mutations in PRC2 components occur in a subset of haematopoietic malignancies, sug- gesting that this complex plays a dichotomous and poorly understood role in cancer2,3. Here we provide genomic, cellular, and mouse mod- elling data demonstrating that the polycomb group gene SUZ12 func- tions as tumour suppressor in PNS tumours, high-grade gliomas and melanomas by cooperating with mutations in NF1. NF1 encodes a Ras GTPase-activating protein (RasGAP) and its loss drives cancer by activating Ras4. We show that SUZ12 loss potentiates the effects of NF1 mutations by amplifying Ras-driven transcription through effects on chromatin. Importantly, however, SUZ12 inactivation also triggers an epigenetic switch that sensitizes these cancers to bromodomain inhib- itors. Collectively, these studies not only reveal an unexpected con- nection between the PRC2 complex, NF1 and Ras, but also identify a promising epigenetic-based therapeutic strategy that may be exploited for a variety of cancers. 9 samples in triplicates, 3x LacZ control, 3x SUZ12 over expression, 3x JQ1 treatment
uses data from: http://identifiers.org/pubmed/25119042

OAS1
type: EnsemblDatabaseReference

8095303
type: EFO_0005072
part of: A-AFFY-141

C15orf54 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: C15orf54 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -2.4
p value: 3.89731256132715E-4
refers to: C15orf54
refers to: 7982593
t statistic: -20.6828196250417

8091678
type: EFO_0005072
part of: A-AFFY-141

FST DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: FST DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.4
p value: 0.00243226717182424
refers to: FST
refers to: 8105302
t statistic: -10.6108388413162

GCH1
type: EnsemblDatabaseReference

8121257
type: EFO_0005072
part of: A-AFFY-141

ANGPT2
type: EnsemblDatabaseReference

TNC
type: EnsemblDatabaseReference

RP11-1002K11.1
type: EnsemblDatabaseReference

SLC34A2 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: IncreasedDifferentialExpressionRatio
label: SLC34A2 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: 1.1
p value: 0.00788795741169946
refers to: SLC34A2
refers to: 8094441
t statistic: 7.24832795520615

PSG4
type: EnsemblDatabaseReference

8054712
type: EFO_0005072
part of: A-AFFY-141

PSTPIP2
type: EnsemblDatabaseReference

RFPL4AL1
type: EnsemblDatabaseReference

8023043
type: EFO_0005072
part of: A-AFFY-141

8094441
type: EFO_0005072
part of: A-AFFY-141

CD274
type: EnsemblDatabaseReference

CCDC80 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: CCDC80 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.2
p value: 0.00444219118080638
refers to: 8089544
refers to: CCDC80
t statistic: -8.62211864218546

SCG5 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: SCG5 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.1
p value: 0.0160380607501764
refers to: SCG5
refers to: 7982366
t statistic: -5.6498400733514

VEPH1
type: EnsemblDatabaseReference

8109752
type: EFO_0005072
part of: A-AFFY-141

HECW2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: HECW2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.0
p value: 0.00162908094798189
refers to: HECW2
refers to: 8057898
t statistic: -12.0675194618168

LY6K
type: EnsemblDatabaseReference

BAMBI
type: EnsemblDatabaseReference

ANGPT1
type: EnsemblDatabaseReference

XAF1
type: EnsemblDatabaseReference

KCNK2
type: EnsemblDatabaseReference

ELOVL6 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: ELOVL6 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.1
p value: 0.0137486180435754
refers to: 8102342
refers to: ELOVL6
t statistic: -5.99832064868307

OAS1
type: EnsemblDatabaseReference

A-AFFY-141
type: EFO_0000269

PAPPA-AS1
type: EnsemblDatabaseReference

HAS2
type: EnsemblDatabaseReference

8024111
type: EFO_0005072
part of: A-AFFY-141

MPP4
type: EnsemblDatabaseReference

8054344
type: EFO_0005072
part of: A-AFFY-141

SLC34A2
type: EnsemblDatabaseReference

TM6SF1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: TM6SF1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.1
p value: 0.00219601965262888
refers to: TM6SF1
refers to: 7985493
t statistic: -11.0063666795319

7909789
type: EFO_0005072
part of: A-AFFY-141

FGF1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: FGF1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -2.1
p value: 0.00140811717343555
refers to: 8114805
refers to: FGF1
t statistic: -12.815353173335

DHRS2
type: EnsemblDatabaseReference

PDE1C
type: EnsemblDatabaseReference

7988414
type: EFO_0005072
part of: A-AFFY-141

FGF5 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: FGF5 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.6
p value: 0.00444219118080638
refers to: FGF5
refers to: 8096050
t statistic: -8.65894153273535

RHOJ
type: EnsemblDatabaseReference

PRRX1
type: EnsemblDatabaseReference

7905067
type: EFO_0005072
part of: A-AFFY-141

8096050
type: EFO_0005072
part of: A-AFFY-141

PSG9
type: EnsemblDatabaseReference

SERPINB7 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: SERPINB7 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.9
p value: 0.00290450252111459
refers to: 8021623
refers to: SERPINB7
t statistic: -9.97345154100655

RFPL4AL1
type: EnsemblDatabaseReference

8091402
type: EFO_0005072
part of: A-AFFY-141

ATP8A1 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: ATP8A1 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 1.1
p value: 6.27352599659583E-4
refers to: 8100026
refers to: ATP8A1
t statistic: 17.2913026393137

7902452
type: EFO_0005072
part of: A-AFFY-141

LIFR
type: EnsemblDatabaseReference

8047763
type: EFO_0005072
part of: A-AFFY-141

SESN3
type: EnsemblDatabaseReference

7909730
type: EFO_0005072
part of: A-AFFY-141

8047467
type: EFO_0005072
part of: A-AFFY-141

8124448
type: EFO_0005072
part of: A-AFFY-141

8145361
type: EFO_0005072
part of: A-AFFY-141

ATP8B1
type: EnsemblDatabaseReference

AK5
type: EnsemblDatabaseReference

SERPINB2
type: EnsemblDatabaseReference

ANO1
type: EnsemblDatabaseReference

MAMDC2
type: EnsemblDatabaseReference

CCDC84
type: EnsemblDatabaseReference

SLC14A1
type: EnsemblDatabaseReference

8100026
type: EFO_0005072
part of: A-AFFY-141

IFI44 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: IFI44 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.0
p value: 0.00816810462128711
refers to: 7902553
refers to: IFI44
t statistic: -7.17146753243336

8105302
type: EFO_0005072
part of: A-AFFY-141

RFPL4AL1 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: RFPL4AL1 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 3.5
p value: 7.74094924610348E-4
refers to: 8031573
refers to: RFPL4AL1
t statistic: 15.6433473207765

KIAA1324L UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: KIAA1324L UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 1.0
p value: 0.00668056833323
refers to: KIAA1324L
refers to: 8140709
t statistic: 7.6518282477066

IFI44L DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: IFI44L DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.7
p value: 3.40382114833491E-4
refers to: IFI44L
refers to: 7902541
t statistic: -21.6830995972543

IL6
type: EnsemblDatabaseReference

(Assay) GSM1275853
type: Assay
has participant: A-AFFY-141

S100A2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: S100A2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.3
p value: 0.00180455762562737
refers to: S100A2
refers to: 7920285
t statistic: -11.7361279105395

Analysis of 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: MicroarrayDifferentialExpressionAnalysis
label: Analysis of 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'

8120468
type: EFO_0005072
part of: A-AFFY-141

GCH1 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: GCH1 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 1.0
p value: 0.0215904935764366
refers to: GCH1
refers to: 7979269
t statistic: 5.18911901419395

8146863
type: EFO_0005072
part of: A-AFFY-141

PSTPIP2
type: EnsemblDatabaseReference

RASGRP3 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: RASGRP3 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -2.6
p value: 4.8640498262433E-5
refers to: 8041422
refers to: RASGRP3
t statistic: -40.0783264789565

SYNE1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: SYNE1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.3
p value: 7.74094924610348E-4
refers to: SYNE1
refers to: 8130211
t statistic: -15.5603055698335

CD274 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: CD274 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.9
p value: 0.00103465696195947
refers to: CD274
refers to: 8154233
t statistic: -14.1150480160079

PARP9 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: PARP9 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.0
p value: 9.17085380594106E-4
refers to: 8090018
refers to: PARP9
t statistic: -14.5363508527517

HIST1H4H
type: EnsemblDatabaseReference

8138888
type: EFO_0005072
part of: A-AFFY-141

(Factor value) GENOTYPE/heterozygous loss and Tyr430 mutation in SUZ12
type: EFO_0000001
property type: GENOTYPE
property value: heterozygous loss and Tyr430 mutation in SUZ12

VEPH1
type: EnsemblDatabaseReference

NEFM
type: EnsemblDatabaseReference

MAMDC2
type: EnsemblDatabaseReference

XAF1
type: EnsemblDatabaseReference

8082100
type: EFO_0005072
part of: A-AFFY-141

HAS2
type: EnsemblDatabaseReference

HIST2H4A
type: EnsemblDatabaseReference

PRDM1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: PRDM1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.8
p value: 0.00402988461276093
refers to: PRDM1
refers to: 8121257
t statistic: -8.97805491342216

IL6
type: EnsemblDatabaseReference

7950933
type: EFO_0005072
part of: A-AFFY-141

TRIM51BP UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: IncreasedDifferentialExpressionRatio
label: TRIM51BP UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: 1.5
p value: 5.15126184730905E-4
refers to: 7943019
refers to: TRIM51BP
t statistic: 19.1443235598199

RBBP6
type: EnsemblDatabaseReference

FST
type: EnsemblDatabaseReference

8131803
type: EFO_0005072
part of: A-AFFY-141

LPXN
type: EnsemblDatabaseReference

DHRS2
type: EnsemblDatabaseReference

PDE1C
type: EnsemblDatabaseReference

PARP14 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: PARP14 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.2
p value: 0.00154891023862121
refers to: 8082100
refers to: PARP14
t statistic: -12.2891978831632

RHOJ
type: EnsemblDatabaseReference

8021623
type: EFO_0005072
part of: A-AFFY-141

7964872
type: EFO_0005072
part of: A-AFFY-141

CCDC84 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: CCDC84 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.2
p value: 0.0207760342317818
refers to: CCDC84
refers to: 7895105
t statistic: -5.25776986994043

FGF5
type: EnsemblDatabaseReference

7951077
type: EFO_0005072
part of: A-AFFY-141

PSTPIP2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: PSTPIP2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.0
p value: 0.026035804472294
refers to: 8023043
refers to: PSTPIP2
t statistic: -4.89589066629237

7926875
type: EFO_0005072
part of: A-AFFY-141

PARP14
type: EnsemblDatabaseReference

7971461
type: EFO_0005072
part of: A-AFFY-141

LIFR
type: EnsemblDatabaseReference

8047300
type: EFO_0005072
part of: A-AFFY-141

7973433
type: EFO_0005072
part of: A-AFFY-141

8130211
type: EFO_0005072
part of: A-AFFY-141

7982366
type: EFO_0005072
part of: A-AFFY-141

SULF1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: SULF1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.4
p value: 0.00132677922576725
refers to: 8146863
refers to: SULF1
t statistic: -13.0089259497443

8095986
type: EFO_0005072
part of: A-AFFY-141

ELOVL6
type: EnsemblDatabaseReference

8021635
type: EFO_0005072
part of: A-AFFY-141

LIFR UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: LIFR UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 1.3
p value: 0.00145784568062672
refers to: LIFR
refers to: 8111677
t statistic: 12.653959488489

RASGRP3
type: EnsemblDatabaseReference

ANXA3
type: EnsemblDatabaseReference

7948332
type: EFO_0005072
part of: A-AFFY-141

ATP8B1
type: EnsemblDatabaseReference

ANO1
type: EnsemblDatabaseReference

AK5
type: EnsemblDatabaseReference

HIST2H4A
type: EnsemblDatabaseReference

LPHN3
type: EnsemblDatabaseReference

GLT8D2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: GLT8D2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.1
p value: 0.00372722355780813
refers to: 7965941
refers to: GLT8D2
t statistic: -9.24463942602353

7907222
type: EFO_0005072
part of: A-AFFY-141

CCDC84
type: EnsemblDatabaseReference

SLC14A1
type: EnsemblDatabaseReference

RBBP6
type: EnsemblDatabaseReference

FST
type: EnsemblDatabaseReference

RNVU1-15
type: EnsemblDatabaseReference

HERC6 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: HERC6 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.0
p value: 0.00221518335153358
refers to: HERC6
refers to: 8096335
t statistic: -10.9739802149653

IL7R
type: EnsemblDatabaseReference

8149071
type: EFO_0005072
part of: A-AFFY-141

8145766
type: EFO_0005072
part of: A-AFFY-141

TRIM51BP
type: EnsemblDatabaseReference

CXCL12
type: EnsemblDatabaseReference

(Assay) GSM1275861
type: Assay
has participant: A-AFFY-141

8056257
type: EFO_0005072
part of: A-AFFY-141

FGF5
type: EnsemblDatabaseReference

8102342
type: EFO_0005072
part of: A-AFFY-141

IL1B
type: EnsemblDatabaseReference

PDCD1LG2
type: EnsemblDatabaseReference

TNC DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: TNC DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.1
p value: 0.00263794167443091
refers to: TNC
refers to: 8163637
t statistic: -10.365650200616

PTPRB
type: EnsemblDatabaseReference

PAPPA-AS1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: PAPPA-AS1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.0
p value: 0.00514974315778461
refers to: PAPPA-AS1
refers to: 8163672
t statistic: -8.32580396533808

8114805
type: EFO_0005072
part of: A-AFFY-141

ANGPT2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: ANGPT2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.4
p value: 7.74094924610348E-4
refers to: ANGPT2
refers to: 8149071
t statistic: -15.5967643081346

RP11-665E10.5
type: EnsemblDatabaseReference

(Sample) cell type/malignant peripheral nerve sheath tumour cell
type: EFO_0000001
property type: cell type
property value: malignant peripheral nerve sheath tumour cell

DHRS2 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: DHRS2 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 1.3
p value: 0.00277139996894985
refers to: DHRS2
refers to: 7973433
t statistic: 10.0870979625076

HIST1H4H
type: EnsemblDatabaseReference

ANXA3
type: EnsemblDatabaseReference

NRP2
type: EnsemblDatabaseReference

APOBEC3B DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: APOBEC3B DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.0
p value: 0.00931110425403281
refers to: 8073062
refers to: APOBEC3B
t statistic: -6.7881940491608

8023497
type: EFO_0005072
part of: A-AFFY-141

ZSCAN4 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: IncreasedDifferentialExpressionRatio
label: ZSCAN4 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: 3.4
p value: 3.79491904546913E-4
refers to: 8031799
refers to: ZSCAN4
t statistic: 21.0256040708375

IFIH1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: IFIH1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.2
p value: 0.00444219118080638
refers to: IFIH1
refers to: 8056285
t statistic: -8.67401118036159

7979269
type: EFO_0005072
part of: A-AFFY-141

AK5 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: AK5 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.7
p value: 0.00112653332625726
refers to: AK5
refers to: 7902452
t statistic: -13.7147720499523

NEFM
type: EnsemblDatabaseReference

LPHN3
type: EnsemblDatabaseReference

TENM2
type: EnsemblDatabaseReference

PTPRB DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: PTPRB DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.0
p value: 0.00132677922576725
refers to: PTPRB
refers to: 7964872
t statistic: -13.1664244403614

(Assay) GSM1275856
type: Assay
has participant: A-AFFY-141

BAI3
type: EnsemblDatabaseReference

SAMD9L
type: EnsemblDatabaseReference

(Sample) genotype/NF1 region (incl. SUZ12) heterozygous microdeletion and Tyr430 mutation in SUZ12
type: EFO_0000001
property type: genotype
property value: NF1 region (incl. SUZ12) heterozygous microdeletion and Tyr430 mutation in SUZ12

RP11-432M8.8
type: EnsemblDatabaseReference

7897978
type: EFO_0005072
part of: A-AFFY-141

AOX1
type: EnsemblDatabaseReference

8006433
type: EFO_0005072
part of: A-AFFY-141

8096335
type: EFO_0005072
part of: A-AFFY-141

HECW2
type: EnsemblDatabaseReference

ADAMTS6 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: ADAMTS6 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.1
p value: 0.00263794167443091
refers to: ADAMTS6
refers to: 8112342
t statistic: -10.3102733000923

GPR126
type: EnsemblDatabaseReference

S100A2
type: EnsemblDatabaseReference

CXCL12
type: EnsemblDatabaseReference

RP11-432M8.8 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: IncreasedDifferentialExpressionRatio
label: RP11-432M8.8 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: 2.8
p value: 0.00196164078631387
refers to: 8104617
refers to: RP11-432M8.8
t statistic: 11.3933470342047

TM4SF18 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: TM4SF18 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -3.0
p value: 5.66781785690306E-4
refers to: 8091402
refers to: TM4SF18
t statistic: -18.5073449001793

LPXN
type: EnsemblDatabaseReference

8058857
type: EFO_0005072
part of: A-AFFY-141

8148553
type: EFO_0005072
part of: A-AFFY-141

(Assay) GSM1275860
type: Assay
has participant: A-AFFY-141

TMEM244
type: EnsemblDatabaseReference

8126428
type: EFO_0005072
part of: A-AFFY-141

8021081
type: EFO_0005072
part of: A-AFFY-141

7943019
type: EFO_0005072
part of: A-AFFY-141

8031799
type: EFO_0005072
part of: A-AFFY-141

KLHL24 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: KLHL24 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 1.1
p value: 0.00263794167443091
refers to: KLHL24
refers to: 8084219
t statistic: 10.3451018557075

PARP14
type: EnsemblDatabaseReference

PDE1C DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: PDE1C DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.3
p value: 6.27352599659583E-4
refers to: 8138888
refers to: PDE1C
t statistic: -17.9626814543959

KLHL24
type: EnsemblDatabaseReference

8057898
type: EFO_0005072
part of: A-AFFY-141

ELOVL6
type: EnsemblDatabaseReference

LCP1
type: EnsemblDatabaseReference

PDCD1LG2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: PDCD1LG2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.9
p value: 2.64015191958909E-4
refers to: 8154245
refers to: PDCD1LG2
t statistic: -23.2806241484629

RASGRP3
type: EnsemblDatabaseReference

BAI3
type: EnsemblDatabaseReference

ALDH1A1
type: EnsemblDatabaseReference

XAF1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: XAF1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.8
p value: 7.95398902278677E-4
refers to: XAF1
refers to: 8004184
t statistic: -15.4135533851543

AOX1
type: EnsemblDatabaseReference

HECW2
type: EnsemblDatabaseReference

7965941
type: EFO_0005072
part of: A-AFFY-141

SYNE1
type: EnsemblDatabaseReference

PNP
type: EnsemblDatabaseReference

AOX1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: AOX1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.3
p value: 7.48068721556565E-4
refers to: AOX1
refers to: 8047300
t statistic: -16.3946910639642

Homo sapiens
type: OBI_0100026

RNVU1-15
type: EnsemblDatabaseReference

IL7R
type: EnsemblDatabaseReference

LY6K DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: LY6K DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.9
p value: 7.48068721556565E-4
refers to: LY6K
refers to: 8148553
t statistic: -16.5155091654812

IFI44
type: EnsemblDatabaseReference

SULF1
type: EnsemblDatabaseReference

TMEM47 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: TMEM47 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 1.5
p value: 0.00132677922576725
refers to: TMEM47
refers to: 8172022
t statistic: 13.0171526341101

BAI3 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: BAI3 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.1
p value: 0.00689523281986391
refers to: 8120468
refers to: BAI3
t statistic: -7.55952127590043

TRIM51BP
type: EnsemblDatabaseReference

SAMD9L DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: SAMD9L DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.1
p value: 0.00937377188652747
refers to: 8140971
refers to: SAMD9L
t statistic: -6.76881235352848

FGF1
type: EnsemblDatabaseReference

CCDC80
type: EnsemblDatabaseReference

PRAMEF1
type: EnsemblDatabaseReference

IL1B
type: EnsemblDatabaseReference

8163672
type: EFO_0005072
part of: A-AFFY-141

8030974
type: EFO_0005072
part of: A-AFFY-141

PTPRB
type: EnsemblDatabaseReference

PDCD1LG2
type: EnsemblDatabaseReference

RP11-665E10.5
type: EnsemblDatabaseReference

LCP1
type: EnsemblDatabaseReference

(Assay) GSM1275855
type: Assay
has participant: A-AFFY-141

SERPINB2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: SERPINB2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.4
p value: 7.48068721556565E-4
refers to: 8021635
refers to: SERPINB2
t statistic: -16.3187076856964

8004184
type: EFO_0005072
part of: A-AFFY-141

ALDH1A1
type: EnsemblDatabaseReference

NRP2
type: EnsemblDatabaseReference

CCL2
type: EnsemblDatabaseReference

8172022
type: EFO_0005072
part of: A-AFFY-141

HAS2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: HAS2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -2.2
p value: 2.16814046569084E-4
refers to: HAS2
refers to: 8152617
t statistic: -24.9273025363943

TGFB2
type: EnsemblDatabaseReference

TENM2
type: EnsemblDatabaseReference

MPP4 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: MPP4 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.0
p value: 0.00159351838670553
refers to: 8058273
refers to: MPP4
t statistic: -12.1738829600277

SAMD9L
type: EnsemblDatabaseReference

8140709
type: EFO_0005072
part of: A-AFFY-141

OAS1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: OAS1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.1
p value: 0.0119717936394919
refers to: OAS1
refers to: 7958884
t statistic: -6.24992992855447

7919560
type: EFO_0005072
part of: A-AFFY-141

RP11-432M8.8
type: EnsemblDatabaseReference

LCP1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: LCP1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.1
p value: 0.00266435204403714
refers to: LCP1
refers to: 7971461
t statistic: -10.2047144241249

8058273
type: EFO_0005072
part of: A-AFFY-141

(Factor value) COMPOUND/DMSO control
type: EFO_0000001
property type: COMPOUND
property value: DMSO control

TRERF1
type: EnsemblDatabaseReference

IFI44L
type: EnsemblDatabaseReference

7920285
type: EFO_0005072
part of: A-AFFY-141

IFIH1
type: EnsemblDatabaseReference

GPR126
type: EnsemblDatabaseReference

C15orf54
type: EnsemblDatabaseReference

SULF1
type: EnsemblDatabaseReference

S100A2
type: EnsemblDatabaseReference

IFI44
type: EnsemblDatabaseReference

FAP DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: FAP DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.2
p value: 0.00429478715849115
refers to: FAP
refers to: 8056257
t statistic: -8.80869040959437

(Sample) organism/Homo sapiens
type: Homo sapiens
property type: organism
property value: Homo sapiens

8104901
type: EFO_0005072
part of: A-AFFY-141

APOBEC3B
type: EnsemblDatabaseReference

SLC14A1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: SLC14A1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.3
p value: 2.41985179291034E-4
refers to: SLC14A1
refers to: 8021081
t statistic: -24.0214222709755

CNN2
type: EnsemblDatabaseReference

TMEM244
type: EnsemblDatabaseReference

ATP8A1
type: EnsemblDatabaseReference

ADAMTS6
type: EnsemblDatabaseReference

(Assay) GSM1275857
type: Assay
has participant: A-AFFY-141

CXCL12 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: CXCL12 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -2.1
p value: 4.8640498262433E-5
refers to: CXCL12
refers to: 7933194
t statistic: -38.7571975811197

KLHL24
type: EnsemblDatabaseReference

RNVU1-15 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: IncreasedDifferentialExpressionRatio
label: RNVU1-15 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: 1.5
p value: 0.016684259329671
refers to: RNVU1-15
refers to: 7919560
t statistic: 5.58807159195804

CCL2
type: EnsemblDatabaseReference

RFX8
type: EnsemblDatabaseReference

PSG4 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: PSG4 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.3
p value: 0.00264231170730401
refers to: 8037283
refers to: PSG4
t statistic: -10.276291842631

PARP9
type: EnsemblDatabaseReference

IL1A
type: EnsemblDatabaseReference

8089544
type: EFO_0005072
part of: A-AFFY-141

8104617
type: EFO_0005072
part of: A-AFFY-141

IGFBP5
type: EnsemblDatabaseReference

FAP
type: EnsemblDatabaseReference

(Factor value) COMPOUND/JQ1 bromodomain inhibitor
type: EFO_0000001
property type: COMPOUND
property value: JQ1 bromodomain inhibitor

GATM
type: EnsemblDatabaseReference

8041422
type: EFO_0005072
part of: A-AFFY-141

TENM2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: TENM2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.0
p value: 0.00851062228923317
refers to: TENM2
refers to: 8109752
t statistic: -7.07589828135838

PNP UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: IncreasedDifferentialExpressionRatio
label: PNP UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: 1.5
p value: 0.00385335979333832
refers to: PNP
refers to: 7973067
t statistic: 9.17520049432745

TM6SF1
type: EnsemblDatabaseReference

IFI44L
type: EnsemblDatabaseReference

SYNE1
type: EnsemblDatabaseReference

PNP
type: EnsemblDatabaseReference

RFX8 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: RFX8 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.1
p value: 0.0136217581379728
refers to: 8054344
refers to: RFX8
t statistic: -6.02058098322148

NOX4
type: EnsemblDatabaseReference

APOBEC3B
type: EnsemblDatabaseReference

8054722
type: EFO_0005072
part of: A-AFFY-141

ANGPT1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: ANGPT1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.6
p value: 7.74094924610348E-4
refers to: ANGPT1
refers to: 8152297
t statistic: -16.0264644186901

IL1A DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: IL1A DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.9
p value: 2.02899996173573E-4
refers to: IL1A
refers to: 8054712
t statistic: -26.4033109018734

(Assay) GSM1275854
type: Assay
has participant: A-AFFY-141

(Sample) genotype/NF1 region (incl. SUZ12) heterozygous microdeletion and Tyr430 mutation in SUZ12 with re-expressed SUZ12
type: EFO_0000001
property type: genotype
property value: NF1 region (incl. SUZ12) heterozygous microdeletion and Tyr430 mutation in SUZ12 with re-expressed SUZ12

(Factor value) GENOTYPE/heterozygous loss and Tyr430 mutation in SUZ12 with re-expressed SUZ12
type: EFO_0000001
property type: GENOTYPE
property value: heterozygous loss and Tyr430 mutation in SUZ12 with re-expressed SUZ12

8161755
type: EFO_0005072
part of: A-AFFY-141

FGF1
type: EnsemblDatabaseReference

CCDC80
type: EnsemblDatabaseReference

8122365
type: EFO_0005072
part of: A-AFFY-141

TRERF1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: TRERF1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.2
p value: 0.00442376612122745
refers to: TRERF1
refers to: 8126428
t statistic: -8.7139356101969

PRAMEF1
type: EnsemblDatabaseReference

PARP9
type: EnsemblDatabaseReference

IL1B DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: IL1B DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -2.6
p value: 2.13647880643278E-4
refers to: IL1B
refers to: 8054722
t statistic: -25.5352377405974

7973067
type: EFO_0005072
part of: A-AFFY-141

8037283
type: EFO_0005072
part of: A-AFFY-141

GATM UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: GATM UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 1.1
p value: 0.00394675762506947
refers to: 7988414
refers to: GATM
t statistic: 9.10461835580443

7958884
type: EFO_0005072
part of: A-AFFY-141

PSG9 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: PSG9 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.0
p value: 0.00429478715849115
refers to: PSG9
refers to: 8037290
t statistic: -8.78618506002996

8154233
type: EFO_0005072
part of: A-AFFY-141

7994161
type: EFO_0005072
part of: A-AFFY-141

FAM90A27P UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: IncreasedDifferentialExpressionRatio
label: FAM90A27P UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: 1.4
p value: 0.00652687335267567
refers to: FAM90A27P
refers to: 8030974
t statistic: 7.69446948125739

KIAA1324L
type: EnsemblDatabaseReference

TGFB2
type: EnsemblDatabaseReference

HERC6
type: EnsemblDatabaseReference

NEFM UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: NEFM UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 1.7
p value: 0.00150575302423914
refers to: NEFM
refers to: 8145361
t statistic: 12.4759653706997

TM6SF1
type: EnsemblDatabaseReference

ZSCAN4
type: EnsemblDatabaseReference

TMEM47
type: EnsemblDatabaseReference

8084219
type: EFO_0005072
part of: A-AFFY-141

SERPINB7
type: EnsemblDatabaseReference

8090018
type: EFO_0005072
part of: A-AFFY-141

8154245
type: EFO_0005072
part of: A-AFFY-141

TRERF1
type: EnsemblDatabaseReference

NOX4
type: EnsemblDatabaseReference

IFIH1
type: EnsemblDatabaseReference

TGFB2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: TGFB2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.4
p value: 8.71309158753917E-4
refers to: TGFB2
refers to: 7909789
t statistic: -14.998274430298

C15orf54
type: EnsemblDatabaseReference

7985493
type: EFO_0005072
part of: A-AFFY-141

RHOJ DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: RHOJ DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.6
p value: 1.93239527857318E-4
refers to: RHOJ
refers to: 7974902
t statistic: -27.4129458959054

8111677
type: EFO_0005072
part of: A-AFFY-141

CNN2
type: EnsemblDatabaseReference

BAMBI UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: BAMBI UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 1.2
p value: 0.00415449506016554
refers to: 7926875
refers to: BAMBI
t statistic: 8.90872879889747

ATP8A1
type: EnsemblDatabaseReference

8055494
type: EFO_0005072
part of: A-AFFY-141

PRRX1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: PRRX1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.3
p value: 3.2027153790906E-4
refers to: PRRX1
refers to: 7907222
t statistic: -22.2121730371065

8163637
type: EFO_0005072
part of: A-AFFY-141

8152617
type: EFO_0005072
part of: A-AFFY-141

FAM90A27P
type: EnsemblDatabaseReference

TMEM244 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: TMEM244 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.9
p value: 0.00166738231317258
refers to: TMEM244
refers to: 8129476
t statistic: -11.9980307526084

ADAMTS6
type: EnsemblDatabaseReference

GLT8D2
type: EnsemblDatabaseReference

7942135
type: EFO_0005072
part of: A-AFFY-141

CCL2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: CCL2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.5
p value: 8.71309158753917E-4
refers to: CCL2
refers to: 8006433
t statistic: -14.9595194114036

IL7R DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: IL7R DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -2.8
p value: 9.51442896036113E-5
refers to: IL7R
refers to: 8104901
t statistic: -31.8841083934721

8152297
type: EFO_0005072
part of: A-AFFY-141

7933194
type: EFO_0005072
part of: A-AFFY-141

RFX8
type: EnsemblDatabaseReference

KIAA1324L
type: EnsemblDatabaseReference

RBBP6 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: IncreasedDifferentialExpressionRatio
label: RBBP6 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: 1.4
p value: 0.00132677922576725
refers to: RBBP6
refers to: 7994161
t statistic: 13.054197931678

KCNK2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: KCNK2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.7
p value: 8.13052792696372E-4
refers to: KCNK2
refers to: 7909730
t statistic: -15.2519304219643

IGFBP5
type: EnsemblDatabaseReference

7974902
type: EFO_0005072
part of: A-AFFY-141

IL1A
type: EnsemblDatabaseReference

IGFBP5 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: IGFBP5 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.5
p value: 0.0021385655115267
refers to: IGFBP5
refers to: 8058857
t statistic: -11.1057716936808

MAMDC2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: MAMDC2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.1
p value: 0.0052986168730269
refers to: MAMDC2
refers to: 8155754
t statistic: -8.2460100343468

HERC6
type: EnsemblDatabaseReference

ZSCAN4
type: EnsemblDatabaseReference

FAP
type: EnsemblDatabaseReference

RP11-1002K11.1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: RP11-1002K11.1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -2.2
p value: 4.8640498262433E-5
refers to: 8145766
refers to: RP11-1002K11.1
t statistic: -37.2374320523506

SCG5
type: EnsemblDatabaseReference

HIST2H4A UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: HIST2H4A UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 2.0
p value: 8.71309158753917E-4
refers to: HIST2H4A
refers to: 7905067
t statistic: 14.8254440357248

GATM
type: EnsemblDatabaseReference

SERPINB7
type: EnsemblDatabaseReference

GPR126 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: GPR126 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.5
p value: 0.00125074668264366
refers to: GPR126
refers to: 8122365
t statistic: -13.3683104814603

8037290
type: EFO_0005072
part of: A-AFFY-141

SESN3 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: SESN3 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 2.3
p value: 7.74094924610348E-4
refers to: 7951077
refers to: SESN3
t statistic: 15.9179889759726

GCH1
type: EnsemblDatabaseReference

ANGPT2
type: EnsemblDatabaseReference

8129476
type: EFO_0005072
part of: A-AFFY-141

ANXA3 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: ANXA3 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -2.0
p value: 0.00263794167443091
refers to: ANXA3
refers to: 8095986
t statistic: -10.2997949916119

7902541
type: EFO_0005072
part of: A-AFFY-141

8031573
type: EFO_0005072
part of: A-AFFY-141

GLT8D2
type: EnsemblDatabaseReference

NOX4 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: NOX4 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.3
p value: 0.00243226717182424
refers to: NOX4
refers to: 7950933
t statistic: -10.5793493787406

(Assay) GSM1275859
type: Assay
has participant: A-AFFY-141

TM4SF18
type: EnsemblDatabaseReference

PRAMEF1 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: IncreasedDifferentialExpressionRatio
label: PRAMEF1 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: 1.0
p value: 0.021418685792246
refers to: PRAMEF1
refers to: 7897978
t statistic: 5.19965772014229

LY6K
type: EnsemblDatabaseReference

BAMBI
type: EnsemblDatabaseReference

7902553
type: EFO_0005072
part of: A-AFFY-141

CDK15
type: EnsemblDatabaseReference

ANGPT1
type: EnsemblDatabaseReference

KCNK2
type: EnsemblDatabaseReference

LPHN3 UP in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: IncreasedDifferentialExpressionRatio
label: LPHN3 UP in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: 1.1
p value: 0.00184302006102857
refers to: 8095303
refers to: LPHN3
t statistic: 11.5417831432405

7982593
type: EFO_0005072
part of: A-AFFY-141

NRP2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: NRP2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.0
p value: 0.00110416281645431
refers to: NRP2
refers to: 8047763
t statistic: -13.7995077738745

PAPPA-AS1
type: EnsemblDatabaseReference

(Assay) GSM1275858
type: Assay
has participant: A-AFFY-141

SCG5
type: EnsemblDatabaseReference

PRDM1
type: EnsemblDatabaseReference

ATP8B1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: ATP8B1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.3
p value: 7.48068721556565E-4
refers to: 8023497
refers to: ATP8B1
t statistic: -16.3348801352322

IL6 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: IL6 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.1
p value: 0.0144561161140231
refers to: 8131803
refers to: IL6
t statistic: -5.84673957500293

8140971
type: EFO_0005072
part of: A-AFFY-141

MPP4
type: EnsemblDatabaseReference

CNN2 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: CNN2 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.0
p value: 0.00322539499620787
refers to: CNN2
refers to: 8024111
t statistic: -9.60372306201434

SLC34A2
type: EnsemblDatabaseReference

TMEM47
type: EnsemblDatabaseReference

8155754
type: EFO_0005072
part of: A-AFFY-141

(Sample) cell line/90-8TL
type: EFO_0000001
property type: cell line
property value: 90-8TL

PRRX1
type: EnsemblDatabaseReference

LPXN DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: LPXN DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.2
p value: 0.00540960290001584
refers to: LPXN
refers to: 7948332
t statistic: -8.19794660907849

TNC
type: EnsemblDatabaseReference

PSG9
type: EnsemblDatabaseReference

CDK15 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: CDK15 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.1
p value: 8.71309158753917E-4
refers to: 8047467
refers to: CDK15
t statistic: -14.7560124495873

ALDH1A1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
type: DecreasedDifferentialExpressionRatio
label: ALDH1A1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
fold change: -1.5
p value: 0.00180455762562737
refers to: ALDH1A1
refers to: 8161755
t statistic: -11.7025549537883

RP11-1002K11.1
type: EnsemblDatabaseReference

ANO1 DOWN in 'mutated SUZ12 with re-expressed SUZ12' vs 'mutated SUZ12 without re-expressed SUZ12' in 'DMSO control'
type: DecreasedDifferentialExpressionRatio
label: ANO1 DOWN in 'JQ1 bromodomain inhibitor' vs 'DMSO control' in 'mutated SUZ12 without re-expressed SUZ12'
fold change: -1.0
p value: 0.00110366182604217
refers to: ANO1
refers to: 7942135
t statistic: -13.8403851960146