Rasgrp2
type: EnsemblDatabaseReference

Adora2a
type: EnsemblDatabaseReference

(Assay) GSM1522553
type: Assay
has participant: A-AFFY-130

Lgals3bp
type: EnsemblDatabaseReference

10496373
type: EFO_0005072
part of: A-AFFY-130

(Assay) GSM1522552
type: Assay
has participant: A-AFFY-130

Cd4
type: EnsemblDatabaseReference

(Sample) genotype/mutant hungtingtin; p62 +/+
type: EFO_0000001
property type: genotype
property value: mutant hungtingtin; p62 +/+

Scn4b
type: EnsemblDatabaseReference

(Assay) GSM1522557
type: Assay
has participant: A-AFFY-130

Copa
type: EnsemblDatabaseReference

Ddit4l DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.00296411269434707
refers to: Ddit4l
refers to: 10496373
t statistic: -16.3632111998956

10395659
type: EFO_0005072
part of: A-AFFY-130

10393573
type: EFO_0005072
part of: A-AFFY-130

Arfgef1 UP in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0216036642710259
refers to: Arfgef1
refers to: 10340339
t statistic: 5.07975327829738

Rab14
type: EnsemblDatabaseReference

Ddit4l
type: EnsemblDatabaseReference

Kl
type: EnsemblDatabaseReference

Anapc1 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0345009053132389
refers to: 10338973
refers to: Anapc1
t statistic: 3.9064507377856

Lrrc10b
type: EnsemblDatabaseReference

Kl
type: EnsemblDatabaseReference

Cnr1 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.3
p value: 0.00296411269434707
refers to: 10503902
refers to: Cnr1
t statistic: -16.7379869778518

Slc17a7 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1
p value: 0.0406372035815836
refers to: Slc17a7
refers to: 10552857
t statistic: -3.89891490450277

Hp1bp3
type: EnsemblDatabaseReference

Cpne9
type: EnsemblDatabaseReference

Ryr1
type: EnsemblDatabaseReference

Gpr139 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.0044122960166615
refers to: 10567361
refers to: Gpr139
t statistic: -14.0414355374968

Hp1bp3
type: EnsemblDatabaseReference

Trdn DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1
p value: 0.0102777402646871
refers to: Trdn
refers to: 10362442
t statistic: -7.30636966752449

E-GEOD-62210
type: microarray 1colour mrna differential
RO_0002162: Mus musculus
description: Huntington's disease (HD) is a dominantly inherited genetic disease caused by mutant huntingtin (htt) protein with expanded polyglutamine tracts. A neuropathological hallmark of HD is the presence of neuronal inclusions of mutant htt. p62 is an important regulatory protein in selective autophagy, a process by which aggregated proteins are degraded, and it is associated with several neurodegenerative disorders including HD. Here we investigated the effect of p62 depletion in three HD model mice: R6/2, HD190QG and HD120QG mice. We found that loss of p62 in these models led to longer lifespans and reduced nuclear inclusions, although cytoplasmic inclusions increased with polyglutamine length. In mouse embryonic fibroblasts (MEFs) with or without p62, mutant htt with a nuclear localization signal (NLS) showed no difference in nuclear inclusion between the two MEF types. In the case of mutant htt without NLS, however, p62 depletion increased cytoplasmic inclusions. Furthermore, to examine the effect of impaired autophagy in HD model mice, we crossed R6/2 mice with Atg5 conditional knockout mice. These mice also showed decreased nuclear inclusions and increased cytoplasmic inclusions, similar to HD mice lacking p62. These data suggest that the genetic ablation of p62 in HD model mice enhances cytoplasmic inclusion formation by interrupting autophagic clearance of polyQ inclusions. This reduces polyQ nuclear influx and paradoxically ameliorates disease phenotypes by decreasing toxic nuclear inclusions. Gene expression profiles were analyzed to examine the effects of p62 depletion in mouse with or without mutant huntingtin exon 1 To examine the effect of p62 depletion on the transcriptome of Huntington's disease model mice, we crossed p62 knockout mice with HD model mice. We extracted total RNA from the striatum of these mice at 8 weeks and used for a microaaray analysis. The samples are HD transgenic mice with p62 knockout (HD_p62KO), HD mice with normal p62 (HD_p62WT), no…

Arfgef1
type: EnsemblDatabaseReference

10607499
type: EFO_0005072
part of: A-AFFY-130

Adora2a DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.00556809920802712
refers to: Adora2a
refers to: 10364030
t statistic: -11.9957386453714

Kcnj13 UP in 'wild type huntingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 2.3
p value: 0.00471537288951949
refers to: 10356403
refers to: Kcnj13
t statistic: 12.3505606766411

Nptx1 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.039701103448891
refers to: 10393662
refers to: Nptx1
t statistic: -3.94407237947126

(Factor value) GENOTYPE/wild type huntingtin; p62 +/+
type: EFO_0000001
property type: GENOTYPE
property value: wild type huntingtin; p62 +/+

Hp1bp3 UP in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.3
p value: 0.0256203219993899
refers to: Hp1bp3
refers to: 10344363
t statistic: 4.72879748192042

Lrrc10b DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.00776956616844387
refers to: 10465963
refers to: Lrrc10b
t statistic: -8.76704668666316

Npas4
type: EnsemblDatabaseReference

(Sample) organism part/striatum
type: UBERON_0000369
property type: organism part
property value: striatum

Rgs4
type: EnsemblDatabaseReference

10359908
type: EFO_0005072
part of: A-AFFY-130

A-AFFY-130
type: EFO_0000269

Rab14 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2
p value: 0.023024606497655
refers to: Rab14
refers to: 10341568
t statistic: 4.66613192615082

Coch
type: EnsemblDatabaseReference

10454192
type: EFO_0005072
part of: A-AFFY-130

Nrn1
type: EnsemblDatabaseReference

Ube2g1
type: EnsemblDatabaseReference

10356403
type: EFO_0005072
part of: A-AFFY-130

10343895
type: EFO_0005072
part of: A-AFFY-130

Anapc1 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.1
p value: 0.0238588456164697
refers to: 10342040
refers to: Anapc1
t statistic: 4.58501241295256

Derl1 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.3
p value: 0.0195752785052102
refers to: 10343030
refers to: Derl1
t statistic: 5.03976846920853

Kcnj13
type: EnsemblDatabaseReference

10540599
type: EFO_0005072
part of: A-AFFY-130

Anapc1 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2
p value: 0.0198302331435833
refers to: 10340852
refers to: Anapc1
t statistic: 5.00699179237697

Psma1 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.3
p value: 0.00668590025335931
refers to: Psma1
refers to: 10338968
t statistic: 9.84948158121518

10364030
type: EFO_0005072
part of: A-AFFY-130

Rgs4 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.00804506406702883
refers to: 10359908
refers to: Rgs4
t statistic: -8.62751004000914

Gm10754
type: EnsemblDatabaseReference

Itch
type: EnsemblDatabaseReference

Rab14 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2
p value: 0.0188924596774975
refers to: Rab14
refers to: 10340583
t statistic: 5.11224237902939

Akr1e1
type: EnsemblDatabaseReference

Cpne9 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1
p value: 0.0044122960166615
refers to: Cpne9
refers to: 10540599
t statistic: -12.9487341321605

Ttr
type: EnsemblDatabaseReference

Rasgrp2 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1
p value: 0.00435407786911338
refers to: Rasgrp2
refers to: 10460968
t statistic: -14.3658333016966

Itch
type: EnsemblDatabaseReference

Gm22805 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.5
p value: 0.00435407786911338
refers to: 10593191
refers to: Gm22805
t statistic: -14.0178827628464

Cnr1
type: EnsemblDatabaseReference

Gpx6
type: EnsemblDatabaseReference

Gpr139
type: EnsemblDatabaseReference

Npas4 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1
p value: 0.0219526360900491
refers to: 10464905
refers to: Npas4
t statistic: -4.76619452827788

Sqstm1 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -2.7
p value: 3.28408597134094E-5
refers to: Sqstm1
refers to: 10385572
t statistic: -43.2480914083275

Cnr1
type: EnsemblDatabaseReference

(Assay) GSM1522562
type: Assay
has participant: A-AFFY-130

Trdn
type: EnsemblDatabaseReference

Akr1e1 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0263006098016654
refers to: Akr1e1
refers to: 10407467
t statistic: 4.39545780867527

10343030
type: EFO_0005072
part of: A-AFFY-130

Gpx6 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.7
p value: 0.00986625662219999
refers to: Gpx6
refers to: 10403911
t statistic: -7.51747049582784

(Assay) GSM1522558
type: Assay
has participant: A-AFFY-130

10460968
type: EFO_0005072
part of: A-AFFY-130

Abi3bp DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.2
p value: 0.00556809920802712
refers to: Abi3bp
refers to: 10436304
t statistic: -10.9860943215832

10593191
type: EFO_0005072
part of: A-AFFY-130

Sar1a
type: EnsemblDatabaseReference

(Sample) genotype/mutant hungtingtin; p62 -/-
type: EFO_0000001
property type: genotype
property value: mutant hungtingtin; p62 -/-

Nrn1 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1
p value: 0.0290235417036122
refers to: 10408689
refers to: Nrn1
t statistic: -4.48366359144105

Abi3bp DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.3
p value: 0.0044122960166615
refers to: 10436304
refers to: Abi3bp
t statistic: -13.2808352611106

Kl UP in 'wild type huntingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0107427906932695
refers to: Kl
refers to: 10527870
t statistic: 10.1554548519393

Cntnap3
type: EnsemblDatabaseReference

Abi3bp
type: EnsemblDatabaseReference

Dlg1
type: EnsemblDatabaseReference

Anapc1 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0277309702353182
refers to: Anapc1
refers to: 10341613
t statistic: 4.28708512835815

Mtif2
type: EnsemblDatabaseReference

Derl1
type: EnsemblDatabaseReference

Dlg1 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.4
p value: 0.0200350502864121
refers to: 10340631
refers to: Dlg1
t statistic: 4.97397951292879

(Factor value) GENOTYPE/mutant hungtingtin; p62 -/-
type: EFO_0000001
property type: GENOTYPE
property value: mutant hungtingtin; p62 -/-

10547894
type: EFO_0005072
part of: A-AFFY-130

Rab14 UP in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0075057498594336
refers to: Rab14
refers to: 10341879
t statistic: 9.54769175897118

Rgs4 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.00997702172799836
refers to: Rgs4
refers to: 10359908
t statistic: -7.70367195221509

(Sample) age/8
type: EFO_0000001
property type: age
property value: 8

Nptx1
type: EnsemblDatabaseReference

10338973
type: EFO_0005072
part of: A-AFFY-130

Rasgrp2
type: EnsemblDatabaseReference

10407467
type: EFO_0005072
part of: A-AFFY-130

Trdn DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.0245252210824099
refers to: Trdn
refers to: 10362426
t statistic: -4.81705307033714

Ifit3
type: EnsemblDatabaseReference

Analysis of 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: MicroarrayDifferentialExpressionAnalysis

Cd4
type: EnsemblDatabaseReference

10342040
type: EFO_0005072
part of: A-AFFY-130

10410150
type: EFO_0005072
part of: A-AFFY-130

Copa
type: EnsemblDatabaseReference

10472649
type: EFO_0005072
part of: A-AFFY-130

(Factor value) GENOTYPE/wild type huntingtin; p62 -/-
type: EFO_0000001
property type: GENOTYPE
property value: wild type huntingtin; p62 -/-

Cntnap3 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.00435407786911338
refers to: Cntnap3
refers to: 10410150
t statistic: -15.2900248842676

Cpne9 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1
p value: 0.00804506406702883
refers to: Cpne9
refers to: 10540599
t statistic: -8.55394448652949

Anapc1 UP in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0171860941219951
refers to: Anapc1
refers to: 10338973
t statistic: 5.66231217195835

10338384
type: EFO_0005072
part of: A-AFFY-130

10362426
type: EFO_0005072
part of: A-AFFY-130

Gm22805
type: EnsemblDatabaseReference

Cd4 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.00435407786911338
refers to: Cd4
refers to: 10547894
t statistic: -13.5480797804928

10408689
type: EFO_0005072
part of: A-AFFY-130

(Assay) GSM1522559
type: Assay
has participant: A-AFFY-130

Phex DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1
p value: 0.00631429748995922
refers to: Phex
refers to: 10607499
t statistic: -10.2108424232013

Ddit4l
type: EnsemblDatabaseReference

Gm22805 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.0435951537649435
refers to: Gm22805
refers to: 10593191
t statistic: -3.78269113212565

10372106
type: EFO_0005072
part of: A-AFFY-130

10338968
type: EFO_0005072
part of: A-AFFY-130

(Assay) GSM1522561
type: Assay
has participant: A-AFFY-130

10462618
type: EFO_0005072
part of: A-AFFY-130

Scn4b DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.9
p value: 0.0012028142634206
refers to: Scn4b
refers to: 10584862
t statistic: -21.4313605932396

(Sample) genotype/wild type huntingtin; p62 +/+
type: EFO_0000001
property type: genotype
property value: wild type huntingtin; p62 +/+

Anapc1 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0160325907842096
refers to: 10339767
refers to: Anapc1
t statistic: 5.54408887997104

Ifit3 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.1
p value: 0.0115517834152702
refers to: 10462618
refers to: Ifit3
t statistic: 6.72905716291797

Psma1
type: EnsemblDatabaseReference

Gm10754 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -2.0
p value: 0.00458861130862081
refers to: Gm10754
refers to: 10372106
t statistic: -12.0307941473929

Ryr1
type: EnsemblDatabaseReference

Adora2a
type: EnsemblDatabaseReference

Hp1bp3 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2
p value: 0.0200436005817382
refers to: Hp1bp3
refers to: 10344363
t statistic: 4.96562427505308

10339059
type: EFO_0005072
part of: A-AFFY-130

Arfgef1
type: EnsemblDatabaseReference

Lgals3bp
type: EnsemblDatabaseReference

10341568
type: EFO_0005072
part of: A-AFFY-130

Rab14 UP in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0367163156462906
refers to: Rab14
refers to: 10341568
t statistic: 4.06332331460683

10344363
type: EFO_0005072
part of: A-AFFY-130

10567361
type: EFO_0005072
part of: A-AFFY-130

Scn4b
type: EnsemblDatabaseReference

10362442
type: EFO_0005072
part of: A-AFFY-130

10403911
type: EFO_0005072
part of: A-AFFY-130

Myo3b DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.00986625662219999
refers to: Myo3b
refers to: 10472649
t statistic: -7.52763229675378

Rab14
type: EnsemblDatabaseReference

Phex
type: EnsemblDatabaseReference

10340583
type: EFO_0005072
part of: A-AFFY-130

Phex
type: EnsemblDatabaseReference

Gpr139 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.2
p value: 0.0021050535674085
refers to: 10567361
refers to: Gpr139
t statistic: -18.8643779052925

(Factor value) GENOTYPE/mutant hungtingtin; p62 +/+
type: EFO_0000001
property type: GENOTYPE
property value: mutant hungtingtin; p62 +/+

Ddit4l DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1
p value: 0.00435407786911338
refers to: 10496373
refers to: Ddit4l
t statistic: -13.1305467209964

Coch
type: EnsemblDatabaseReference

10341613
type: EFO_0005072
part of: A-AFFY-130

Lrrc10b
type: EnsemblDatabaseReference

Nrn1
type: EnsemblDatabaseReference

(Sample) organism/Mus musculus
type: Mus musculus
property type: organism
property value: Mus musculus

Sqstm1
type: EnsemblDatabaseReference

10503902
type: EFO_0005072
part of: A-AFFY-130

Sqstm1
type: EnsemblDatabaseReference

Lgals3bp UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0109124372585147
refers to: Lgals3bp
refers to: 10393573
t statistic: 6.97581871275991

Gpx6 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.6
p value: 0.00961059413731564
refers to: Gpx6
refers to: 10403911
t statistic: -7.99989794537506

Coch DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.0183795250271979
refers to: Coch
refers to: 10395659
t statistic: -5.49654852103159

Cpne9
type: EnsemblDatabaseReference

Analysis of 'wild type huntingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: MicroarrayDifferentialExpressionAnalysis

10465963
type: EFO_0005072
part of: A-AFFY-130

Ttr UP in 'wild type huntingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 2.2
p value: 0.0438340856155445
refers to: Ttr
refers to: 10454192
t statistic: 6.01973730446851

(Assay) GSM1522551
type: Assay
has participant: A-AFFY-130

(Assay) GSM1522560
type: Assay
has participant: A-AFFY-130

10561561
type: EFO_0005072
part of: A-AFFY-130

(Assay) GSM1522554
type: Assay
has participant: A-AFFY-130

10343273
type: EFO_0005072
part of: A-AFFY-130

Gpx6
type: EnsemblDatabaseReference

Sqstm1 DOWN in 'wild type huntingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -3.1
p value: 5.76939969790001E-7
refers to: Sqstm1
refers to: 10385572
t statistic: -52.422351086376

Itch UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.5
p value: 0.0151082057780286
refers to: 10338693
refers to: Itch
t statistic: 5.74463233119147

Akr1e1
type: EnsemblDatabaseReference

Npas4 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.2
p value: 0.0100622234387956
refers to: 10464905
refers to: Npas4
t statistic: -7.68354937077499

Npas4
type: EnsemblDatabaseReference

Trdn
type: EnsemblDatabaseReference

10338745
type: EFO_0005072
part of: A-AFFY-130

Mtif2 UP in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0107814141011169
refers to: Mtif2
refers to: 10343895
t statistic: 7.38353817003771

Rgs4
type: EnsemblDatabaseReference

Trdn DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.8
p value: 0.0163286735874236
refers to: Trdn
refers to: 10362440
t statistic: -5.50375573916805

10362424
type: EFO_0005072
part of: A-AFFY-130

Anapc1
type: EnsemblDatabaseReference

Scn4b DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.8
p value: 0.00157809514230417
refers to: Scn4b
refers to: 10584862
t statistic: -21.1636764311928

10552857
type: EFO_0005072
part of: A-AFFY-130

Anapc1
type: EnsemblDatabaseReference

10339767
type: EFO_0005072
part of: A-AFFY-130

Ryr1 DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.4
p value: 8.97865506804894E-4
refers to: 10561561
refers to: Ryr1
t statistic: -25.5505699660149

10436304
type: EFO_0005072
part of: A-AFFY-130

Gm10754 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -2.0
p value: 0.00435407786911338
refers to: Gm10754
refers to: 10372106
t statistic: -14.2050547812848

Ube2g1
type: EnsemblDatabaseReference

Ryr1 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.4
p value: 9.44061645290652E-4
refers to: Ryr1
refers to: 10561561
t statistic: -23.6198228267696

(Assay) GSM1522555
type: Assay
has participant: A-AFFY-130

Ube2g1 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.3
p value: 0.0153459786834512
refers to: Ube2g1
refers to: 10338384
t statistic: 5.65615825873407

Sar1a
type: EnsemblDatabaseReference

Kcnj13
type: EnsemblDatabaseReference

(Assay) GSM1522556
type: Assay
has participant: A-AFFY-130

Trdn DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.2
p value: 0.0295093243907911
refers to: 10362424
refers to: Trdn
t statistic: -4.18114702409741

Myo3b
type: EnsemblDatabaseReference

Mus musculus
type: OBI_0100026

Myo3b
type: EnsemblDatabaseReference

Gm10754
type: EnsemblDatabaseReference

Rab14 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.4
p value: 0.0116290793191819
refers to: Rab14
refers to: 10343513
t statistic: 6.70257568751262

Abi3bp
type: EnsemblDatabaseReference

10341879
type: EFO_0005072
part of: A-AFFY-130

Mtif2
type: EnsemblDatabaseReference

10362440
type: EFO_0005072
part of: A-AFFY-130

10340339
type: EFO_0005072
part of: A-AFFY-130

Coch DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.0142454166860468
refers to: Coch
refers to: 10395659
t statistic: -5.97112413296816

10385572
type: EFO_0005072
part of: A-AFFY-130

Ttr
type: EnsemblDatabaseReference

Gpr139
type: EnsemblDatabaseReference

Copa UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2
p value: 0.0255931298570862
refers to: Copa
refers to: 10339059
t statistic: 4.44761185587754

10340631
type: EFO_0005072
part of: A-AFFY-130

Slc17a7
type: EnsemblDatabaseReference

Nptx1
type: EnsemblDatabaseReference

(Sample) genotype/wild type huntingtin; p62 -/-
type: EFO_0000001
property type: genotype
property value: wild type huntingtin; p62 -/-

Slc17a7
type: EnsemblDatabaseReference

Analysis of 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: MicroarrayDifferentialExpressionAnalysis

Ifit3
type: EnsemblDatabaseReference

10340852
type: EFO_0005072
part of: A-AFFY-130

10393662
type: EFO_0005072
part of: A-AFFY-130

Arfgef1 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.1
p value: 0.012184240434304
refers to: Arfgef1
refers to: 10340339
t statistic: 6.54740434870412

Phex DOWN in 'mutant hungtingtin; p62 +/+' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.00818162831824287
refers to: Phex
refers to: 10607499
t statistic: -9.30940344429289

Sar1a UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0
p value: 0.0159007601987944
refers to: Sar1a
refers to: 10343273
t statistic: 5.56389513603393

Cntnap3
type: EnsemblDatabaseReference

Cnr1 DOWN in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: DecreasedDifferentialExpressionRatio
fold change: -1.3
p value: 0.00308172438752939
refers to: Cnr1
refers to: 10503902
t statistic: -17.0454229579491

10343513
type: EFO_0005072
part of: A-AFFY-130

Dlg1
type: EnsemblDatabaseReference

Gm22805
type: EnsemblDatabaseReference

10464905
type: EFO_0005072
part of: A-AFFY-130

Derl1
type: EnsemblDatabaseReference

10584862
type: EFO_0005072
part of: A-AFFY-130

10338693
type: EFO_0005072
part of: A-AFFY-130

10527870
type: EFO_0005072
part of: A-AFFY-130

Psma1
type: EnsemblDatabaseReference

Rab14 UP in 'mutant hungtingtin; p62 -/-' vs 'wild type huntingtin; p62 +/+'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2
p value: 0.0125078656375909
refers to: 10338745
refers to: Rab14
t statistic: 6.41760405554013