CKAP4 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
LTBP4 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MMP9 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SLCO3A1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CALB1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SVIL DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ABCG1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ARG2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
Constitutive activation of EGFR- and NF-kB-dependent pathways is a hallmark of cancer, yet signaling proteins that connect both oncogenic cascades are poorly characterized. Here we define KIAA1199 as a BCL-3- and p65-dependent gene in transformed keratinocytes. KIAA1199 expression is enhanced upon human papillomavirus (HPV) infection and is aberrantly expressed in clinical cases of cervical (pre)neoplastic lesions. Mechanistically, KIAA1199 binds Plexin A2 and protects from Semaphorin 3A-mediated cell death by promoting EGFR stability and signaling. Moreover, KIAA1199 is an EGFR-binding protein and KIAA1199 deficiency impairs EGF-dependent Src, MEK1 and ERK1/2 phosphorylations. Therefore, EGFR stability and signaling to downstream kinases requires KIAA1199. As such, KIAA1199 promotes EGF-mediated epithelial-mesenchymal transition (EMT). Taken together, our data define KIAA1199 as an oncogenic protein induced by HPV infection and constitutive NF-kB activity that transmits pro-survival and invasive signals through EGFR signaling. We used microarrays to detail the global programme of gene expression upon BCL-3 overexpression We used two experimental conditions, namely HaCat cells infected with a control lentivirus as well as HaCat cells infected with a BCL-3 expressing construct. Both experimental conditions were in triplicates.
L1CAM UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MMD DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SLC1A3 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SPRR3 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
GABARAPL1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
F2RL1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
LINC00342 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
NEDD9 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ABCA1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SLC2A3 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
IRS1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CXCL8 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
GDF15 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
(Factor value) GENOTYPE/BCL-3-expressing lentiviral construct
NLRP1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MAOA UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MUC1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
PTPRH UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
PKP1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
BDNF DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
RAB29 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MT1X DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CAPRIN2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
NGFR UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TUBA1A UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TIMP3 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
DLX2 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ATP8A2 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
FTH1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ARL4C DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ITGB5 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TGFB2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
HS3ST1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CYP26B1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
HLA-DQB1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CD55 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CITED2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
PALLD UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TAGLN UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
S100P UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
STEAP4 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
LGALS1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
HSD17B2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
PXDN DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
P4HA1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
COL5A3 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
UPK2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
DUSP4 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TM4SF1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TBC1D9 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CRISPLD2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
VTCN1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
Analysis of 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
DUSP5 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SLC6A2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
GSN DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ZFP36L1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TGFB1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
EXTL2 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
PSD3 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CYP24A1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
PANX1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
HEY1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
GLI2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SCEL UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
BCAT1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
KLF12 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
KRT1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
(Factor value) GENOTYPE/empty vector control
PTPRZ1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
IGFBP2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
FGF13 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
LUM UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
LGR4 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
PLAT UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MARCKS DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MMP13 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
DNAJC6 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
KRT10 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TBL1X UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SPRR1A UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CXCL1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MICAL1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
AGR2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
(Sample) genotype/BCL-3-expressing lentiviral construct
PLAUR DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MXRA5 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
STYK1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
RAPGEF3 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TNFRSF11B UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
FZD10 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
LRP4 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
IL1RL1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SERPINB1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SGCE DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
NPL UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
FOXO1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
IER3 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
IL7 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CLDN8 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
PMAIP1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
BCL6 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
GALNT6 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CEMIP UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
PPFIBP2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TSPAN8 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SLC1A1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TMPRSS11E DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
AKR1B10 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SPON2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
D4S234E UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
BHLHE41 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
REEP1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CRLF1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SCNN1A DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MAL UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
NMRK1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SYNGR3 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ADAMTS1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MTUS2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
GPR125 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
FA2H UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
FOS UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
AP1S2 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
DHRS9 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ALDH3A1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ARL14 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
BIK DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
B4GALT5 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MGLL UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
SFRP1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
PSMB9 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CXCL14 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
CYP4B1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MTSS1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
KMO DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
FOXD1 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
HDAC9 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
FLRT2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
HSPB8 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
HILPDA DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ALOX5 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
LBH UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MAF UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
RHOBTB1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
S100A8 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
QKI UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
OLR1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
DUSP1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
NRG2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ELOVL4 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
STAP2 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
ANXA10 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
UCP2 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
TNFRSF1A DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
NFKBIA DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
BCL3 DOWN in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'
MANSC1 UP in 'BCL-3-expressing lentiviral construct' vs 'empty vector control'