Gstm3 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Cd36 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Vldlr UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Ppp1r3g UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Enho DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Analysis of '6.7 milligram per liter penicillin' vs 'none' in 'normal diet'
Orm2 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Gas6 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Gsta2 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Tubb2a UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Osbpl3 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Jun UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Lgals1 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Cela1 DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
2610305D13Rik UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. C57BL6J mice received low-dose penicillin through their drinking water (6.7 mg/L), control mice did not receive antibiotics. All mice were started on normal chow (13.5% fat kcal). At 17 weeks of age, half of the mice were switched to high fat diet (45% fat kcal). Livers were collected at age 30 weeks, RNA was extracted, and transcriptional differences were measured by microarray analysis.
Cidea UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Anxa2 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Grem2 DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Cidec UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Acyp2 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Tfrc UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Tceal8 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Ly6d UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Neat1 DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'normal diet'
Mogat1 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Spc25 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Ugt2b38 DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Slc22a29 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Unc119 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Gprc5b UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Lifr DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Mcm6 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
9130409I23Rik UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Apoa4 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Lcn2 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Tff3 DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Hsd3b5 DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Analysis of '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Cyp2c54 DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
C8b DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Sntg2 DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Bhlhb9 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Rcan2 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Wfdc2 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Gpx6 DOWN in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Slc22a27 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Thbs1 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Ubd UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'
Hao2 UP in '6.7 milligram per liter penicillin' vs 'none' in 'high fat diet'