Ccl5 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Psmb8 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Psmb9 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Mptx1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
H2-DMa DOWN in '6.7 milligram per liter penicillin' vs 'none'
Saa2 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Ceacam10 DOWN in '6.7 milligram per liter penicillin' vs 'none'
B3galt5 DOWN in '6.7 milligram per liter penicillin' vs 'none'
H2-Ab1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Cd3g DOWN in '6.7 milligram per liter penicillin' vs 'none'
Rdh7 UP in '6.7 milligram per liter penicillin' vs 'none'
H2-DMb1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Iigp1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Tap1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Gzmb DOWN in '6.7 milligram per liter penicillin' vs 'none'
Defb1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Gbp6 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Nkg7 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Mal DOWN in '6.7 milligram per liter penicillin' vs 'none'
H2-Eb1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Retnlb DOWN in '6.7 milligram per liter penicillin' vs 'none'
Igj DOWN in '6.7 milligram per liter penicillin' vs 'none'
Igtp DOWN in '6.7 milligram per liter penicillin' vs 'none'
Cd177 DOWN in '6.7 milligram per liter penicillin' vs 'none'
H2-Aa DOWN in '6.7 milligram per liter penicillin' vs 'none'
Igkc DOWN in '6.7 milligram per liter penicillin' vs 'none'
Pfkfb3 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Ubd DOWN in '6.7 milligram per liter penicillin' vs 'none'
Gzma DOWN in '6.7 milligram per liter penicillin' vs 'none'
BC089597 UP in '6.7 milligram per liter penicillin' vs 'none'
Zbp1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. Male mice were exposed to low-dose penicillin (6.7 mg/L), from birth. Ileums were collected at 8 weeks of age, RNA was extracted, and transcriptional differences were measured by microarray analysis.
Igkv6-15 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Nlrc5 DOWN in '6.7 milligram per liter penicillin' vs 'none'
Cyp2d26 UP in '6.7 milligram per liter penicillin' vs 'none'
Analysis of '6.7 milligram per liter penicillin' vs 'none'