1435290_x_at
type: EFO_0005072
part of: A-AFFY-45

H2-DMb1
type: EnsemblDatabaseReference

Gzma
type: EnsemblDatabaseReference

Ccl5 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.34076388138214
p value: 0.00338815170879341
refers to: Ccl5
refers to: 1418126_at
t statistic: -9.11625635344391

1417898_a_at
type: EFO_0005072
part of: A-AFFY-45

Ubd
type: EnsemblDatabaseReference

Psmb8 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.40025312771076
p value: 0.0108908621267476
refers to: Psmb8
refers to: 1422962_a_at
t statistic: -6.61928928476938

Mal
type: EnsemblDatabaseReference

Igkc
type: EnsemblDatabaseReference

Psmb9 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.11495236048211
p value: 0.00619397427936382
refers to: Psmb9
refers to: 1450696_at
t statistic: -7.91274808932303

Mptx1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.08801757081289
p value: 0.00793197258564841
refers to: Mptx1
refers to: 1417735_at
t statistic: -7.32700639149355

Tap1
type: EnsemblDatabaseReference

H2-DMa DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.79928955844015
p value: 0.00403447841687853
refers to: H2-DMa
refers to: 1422527_at
t statistic: -8.78205698713287

(Sample) age/8
type: EFO_0000001
property type: age
property value: 8

1448573_a_at
type: EFO_0005072
part of: A-AFFY-45

Saa2 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -2.01532958424678
p value: 0.0489325246393059
refers to: 1449326_x_at
refers to: Saa2
t statistic: -3.95965270696708

Rdh7
type: EnsemblDatabaseReference

Igkv6-15
type: EnsemblDatabaseReference

1416016_at
type: EFO_0005072
part of: A-AFFY-45

1419762_at
type: EFO_0005072
part of: A-AFFY-45

Gbp6
type: EnsemblDatabaseReference

Mptx1
type: EnsemblDatabaseReference

Ceacam10 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -3.15357541372098
p value: 0.00147442147727138
refers to: 1417074_at
refers to: Ceacam10
t statistic: -12.7339864120561

B3galt5 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.20018795770896
p value: 0.0272675146376721
refers to: B3galt5
refers to: 1428397_at
t statistic: -4.67968384532351

H2-Ab1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.37070373969257
p value: 0.00462530819362796
refers to: H2-Ab1
refers to: 1450648_s_at
t statistic: -8.4897210086865

Cd3g DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.28956720167293
p value: 0.0142937847034053
refers to: Cd3g
refers to: 1419178_at
t statistic: -6.14888215682867

Igtp
type: EnsemblDatabaseReference

Pfkfb3
type: EnsemblDatabaseReference

1447927_at
type: EFO_0005072
part of: A-AFFY-45

Rdh7 UP in '6.7 milligram per liter penicillin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.67875504322729
p value: 0.0392633302183852
refers to: 1448723_at
refers to: Rdh7
t statistic: 4.2808812366868

BC089597
type: EnsemblDatabaseReference

H2-Ab1
type: EnsemblDatabaseReference

Defb1
type: EnsemblDatabaseReference

H2-Ab1
type: EnsemblDatabaseReference

Defb1
type: EnsemblDatabaseReference

Nlrc5
type: EnsemblDatabaseReference

1424305_at
type: EFO_0005072
part of: A-AFFY-45

Ceacam10
type: EnsemblDatabaseReference

H2-DMb1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -2.19410234116592
p value: 0.00141067637034146
refers to: H2-DMb1
refers to: 1418638_at
t statistic: -13.4929739115427

(Sample) strain/C57BL/6J
type: EFO_0000606
property type: strain
property value: C57BL/6J

1419043_a_at
type: EFO_0005072
part of: A-AFFY-45

Cd177
type: EnsemblDatabaseReference

1449326_x_at
type: EFO_0005072
part of: A-AFFY-45

1419060_at
type: EFO_0005072
part of: A-AFFY-45

Igj
type: EnsemblDatabaseReference

Iigp1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.24113581423882
p value: 0.0257448957771636
refers to: Iigp1
refers to: 1419043_a_at
t statistic: -4.77435314767121

H2-Aa
type: EnsemblDatabaseReference

Tap1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01859491914188
p value: 0.0226914164894908
refers to: Tap1
refers to: 1416016_at
t statistic: -5.01381635431412

Ccl5
type: EnsemblDatabaseReference

1450696_at
type: EFO_0005072
part of: A-AFFY-45

H2-Eb1
type: EnsemblDatabaseReference

1418638_at
type: EFO_0005072
part of: A-AFFY-45

Gzmb DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.65121655988554
p value: 0.0226914164894908
refers to: Gzmb
refers to: 1419060_at
t statistic: -5.10387421370221

Defb1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.18133856159952
p value: 0.0186277742733466
refers to: 1419491_at
refers to: Defb1
t statistic: -5.53167782117917

1429947_a_at
type: EFO_0005072
part of: A-AFFY-45

Zbp1
type: EnsemblDatabaseReference

Iigp1
type: EnsemblDatabaseReference

(Sample) organism/Mus musculus
type: Mus musculus
property type: organism
property value: Mus musculus

1424509_at
type: EFO_0005072
part of: A-AFFY-45

Nkg7
type: EnsemblDatabaseReference

Cd3g
type: EnsemblDatabaseReference

Retnlb
type: EnsemblDatabaseReference

Psmb9
type: EnsemblDatabaseReference

H2-DMa
type: EnsemblDatabaseReference

1416432_at
type: EFO_0005072
part of: A-AFFY-45

Cyp2d26
type: EnsemblDatabaseReference

B3galt5
type: EnsemblDatabaseReference

Gbp6 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.19900884440601
p value: 0.0193669841643071
refers to: Gbp6
refers to: 1438676_at
t statistic: -5.45442925435089

Nkg7 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0002732075083
p value: 0.0108908621267476
refers to: Nkg7
refers to: 1450753_at
t statistic: -6.7499522879746

Psmb8
type: EnsemblDatabaseReference

Mal DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.31673090286584
p value: 0.0226914164894908
refers to: 1432558_a_at
refers to: Mal
t statistic: -5.10153079706595

1422962_a_at
type: EFO_0005072
part of: A-AFFY-45

H2-Eb1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.21071903653222
p value: 0.00233736075779707
refers to: H2-Eb1
refers to: 1417025_at
t statistic: -10.0042593625969

H2-DMb1
type: EnsemblDatabaseReference

Gzma
type: EnsemblDatabaseReference

Ubd
type: EnsemblDatabaseReference

1437176_at
type: EFO_0005072
part of: A-AFFY-45

Mal
type: EnsemblDatabaseReference

Retnlb DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -2.65870091382737
p value: 0.0486031349008117
refers to: 1418368_at
refers to: Retnlb
t statistic: -3.97870505531039

H2-Ab1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.54556358311627
p value: 0.00338815170879341
refers to: 1451721_a_at
refers to: H2-Ab1
t statistic: -9.18409699399167

1452463_x_at
type: EFO_0005072
part of: A-AFFY-45

1452431_s_at
type: EFO_0005072
part of: A-AFFY-45

1417074_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM1400507
type: Assay
has participant: A-AFFY-45

Ceacam10 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -3.22547860504802
p value: 1.46347183472721E-4
refers to: Ceacam10
refers to: 1448573_a_at
t statistic: -19.6471771954975

(Factor value) COMPOUND/none
type: EFO_0001461
property type: COMPOUND
property value: none

Igj DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00352978159886
p value: 0.0108557574908685
refers to: Igj
refers to: 1424305_at
t statistic: -6.78575795008839

Igtp DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.23845177636924
p value: 0.0426060271889977
refers to: Igtp
refers to: 1417141_at
t statistic: -4.13628617005371

1451721_a_at
type: EFO_0005072
part of: A-AFFY-45

Cd177 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.45340830679651
p value: 0.00233736075779707
refers to: 1424509_at
refers to: Cd177
t statistic: -10.098810622825

Gzmb
type: EnsemblDatabaseReference

Gzmb
type: EnsemblDatabaseReference

1451681_at
type: EFO_0005072
part of: A-AFFY-45

1450648_s_at
type: EFO_0005072
part of: A-AFFY-45

H2-Aa DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.34058510047364
p value: 0.00338815170879341
refers to: H2-Aa
refers to: 1452431_s_at
t statistic: -9.14985728518766

1417141_at
type: EFO_0005072
part of: A-AFFY-45

Igkc
type: EnsemblDatabaseReference

1417735_at
type: EFO_0005072
part of: A-AFFY-45

1427860_at
type: EFO_0005072
part of: A-AFFY-45

Nlrc5
type: EnsemblDatabaseReference

Tap1
type: EnsemblDatabaseReference

Igkc DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00415069689399
p value: 0.0144004806579331
refers to: 1427455_x_at
refers to: Igkc
t statistic: -6.1251478422327

1419178_at
type: EFO_0005072
part of: A-AFFY-45

1450753_at
type: EFO_0005072
part of: A-AFFY-45

Rdh7
type: EnsemblDatabaseReference

1427455_x_at
type: EFO_0005072
part of: A-AFFY-45

Igkv6-15
type: EnsemblDatabaseReference

Pfkfb3 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.21901432815369
p value: 0.0206300492458876
refers to: Pfkfb3
refers to: 1416432_at
t statistic: -5.32662153321277

Mptx1
type: EnsemblDatabaseReference

Igj
type: EnsemblDatabaseReference

(Assay) GSM1400508
type: Assay
has participant: A-AFFY-45

Gbp6
type: EnsemblDatabaseReference

Ubd DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.61178742296524
p value: 0.0206300492458876
refers to: Ubd
refers to: 1419762_at
t statistic: -5.29276004863327

1417275_at
type: EFO_0005072
part of: A-AFFY-45

Saa2
type: EnsemblDatabaseReference

Saa2
type: EnsemblDatabaseReference

Ccl5
type: EnsemblDatabaseReference

1419042_at
type: EFO_0005072
part of: A-AFFY-45

Igtp
type: EnsemblDatabaseReference

Pfkfb3
type: EnsemblDatabaseReference

1448683_at
type: EFO_0005072
part of: A-AFFY-45

1418368_at
type: EFO_0005072
part of: A-AFFY-45

BC089597
type: EnsemblDatabaseReference

1438676_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM1400505
type: Assay
has participant: A-AFFY-45

Gzma DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -2.29211389577179
p value: 0.0106320359709385
refers to: Gzma
refers to: 1417898_a_at
t statistic: -6.92448146268726

Ceacam10
type: EnsemblDatabaseReference

Retnlb
type: EnsemblDatabaseReference

Nkg7
type: EnsemblDatabaseReference

Cd177
type: EnsemblDatabaseReference

Psmb9
type: EnsemblDatabaseReference

1418126_at
type: EFO_0005072
part of: A-AFFY-45

Igkc DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.28762239803854
p value: 0.0108908621267476
refers to: Igkc
refers to: 1452463_x_at
t statistic: -6.50273661272707

1448723_at
type: EFO_0005072
part of: A-AFFY-45

A-AFFY-45
type: EFO_0000269

(Assay) GSM1400509
type: Assay
has participant: A-AFFY-45

(Sample) sex/male
type: EFO_0001266
property type: sex
property value: male

(Assay) GSM1400511
type: Assay
has participant: A-AFFY-45

BC089597 UP in '6.7 milligram per liter penicillin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.59345095951175
p value: 0.0144715556407848
refers to: BC089597
refers to: 1451681_at
t statistic: 5.93582009113206

H2-DMa
type: EnsemblDatabaseReference

H2-Aa
type: EnsemblDatabaseReference

Mus musculus
type: OBI_0100026

Cyp2d26
type: EnsemblDatabaseReference

1422527_at
type: EFO_0005072
part of: A-AFFY-45

Iigp1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.18511741692462
p value: 0.0193669841643071
refers to: Iigp1
refers to: 1419042_at
t statistic: -5.44064914934067

H2-Eb1
type: EnsemblDatabaseReference

Zbp1 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.11127159360666
p value: 0.0210267056740799
refers to: 1429947_a_at
refers to: Zbp1
t statistic: -5.26825329736929

1428397_at
type: EFO_0005072
part of: A-AFFY-45

Zbp1
type: EnsemblDatabaseReference

Iigp1
type: EnsemblDatabaseReference

E-GEOD-58085
type: microarray 1colour mrna differential
RO_0002162: Mus musculus
description: Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. Male mice were exposed to low-dose penicillin (6.7 mg/L), from birth. Ileums were collected at 8 weeks of age, RNA was extracted, and transcriptional differences were measured by microarray analysis.

Cd3g
type: EnsemblDatabaseReference

1417025_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM1400506
type: Assay
has participant: A-AFFY-45

H2-Aa DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.14081086242774
p value: 0.00233736075779707
refers to: H2-Aa
refers to: 1435290_x_at
t statistic: -10.1660300812602

(Assay) GSM1400510
type: Assay
has participant: A-AFFY-45

1419491_at
type: EFO_0005072
part of: A-AFFY-45

1432558_a_at
type: EFO_0005072
part of: A-AFFY-45

Igkv6-15 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.72891500454338
p value: 0.0481761188086059
refers to: Igkv6-15
refers to: 1427860_at
t statistic: -3.98737598965804

B3galt5
type: EnsemblDatabaseReference

Nlrc5 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.17028718547434
p value: 0.0164923637102873
refers to: Nlrc5
refers to: 1437176_at
t statistic: -5.73793482141909

Mal DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.66680312284797
p value: 0.0164923637102873
refers to: 1417275_at
refers to: Mal
t statistic: -5.75030079933182

Cyp2d26 UP in '6.7 milligram per liter penicillin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.1360867019804
p value: 0.0296143919466254
refers to: Cyp2d26
refers to: 1448683_at
t statistic: 4.58340964941656

Gbp6 DOWN in '6.7 milligram per liter penicillin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.10504600113415
p value: 0.0260427555918005
refers to: Gbp6
refers to: 1447927_at
t statistic: -4.7571913723327

Psmb8
type: EnsemblDatabaseReference

Analysis of '6.7 milligram per liter penicillin' vs 'none'
type: MicroarrayDifferentialExpressionAnalysis

(Factor value) COMPOUND/penicillin 6.7
type: CHEBI_18208
property type: COMPOUND
property value: penicillin 6.7