(Assay) GSM1394565
type: Assay
has participant: A-AFFY-45

Foxq1
type: EnsemblDatabaseReference

Tmem30a
type: EnsemblDatabaseReference

1429549_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM1394568
type: Assay
has participant: A-AFFY-45

Dnajc12
type: EnsemblDatabaseReference

(Factor value) COMPOUND/biomineralized insulin
type: EFO_0000001
property type: COMPOUND
property value: biomineralized insulin

Analysis of 'biomineralized insulin' vs 'none'
type: MicroarrayDifferentialExpressionAnalysis

Phlda1 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.90843984060698
p value: 0.00170174391681132
refers to: Phlda1
refers to: 1418835_at
t statistic: -12.1676701257789

Wsb1
type: EnsemblDatabaseReference

1420835_at
type: EFO_0005072
part of: A-AFFY-45

Gm6484
type: EnsemblDatabaseReference

1420655_at
type: EFO_0005072
part of: A-AFFY-45

Slc25a30 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.39350361512209
p value: 0.00170174391681132
refers to: Slc25a30
refers to: 1420836_at
t statistic: -12.0287578642993

Col27a1
type: EnsemblDatabaseReference

Serpine2
type: EnsemblDatabaseReference

A4gnt UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.14110384289524
p value: 0.0212421117841031
refers to: 1458930_at
refers to: A4gnt
t statistic: 6.52324040707625

1450611_at
type: EFO_0005072
part of: A-AFFY-45

Lbp
type: EnsemblDatabaseReference

E-GEOD-57817
type: microarray 1colour mrna differential
RO_0002162: Mus musculus
description: There is evidence indicating the involvement of DNA methylation memory in maintaining gene expression patterns associated with insulin resistance. Although the exact mechanism remains unknown, it has been proved that insulin resistance is correlated to low heat shock protein (HSP) expression. We reveal that intranuclear insulin can reduce HSP DNA methylation level to up-regulate HSP protein expression and result in long term cure of hyperglycemia. Type 2 diabetes KKAy mouse were selected in our experiments.Three conditions were compared with three replicates each. These are:(1) Untreated KKAy mouse (2) Insulin treated KKAy mouse(Insulin); (3) Biomineralized insulin treated KKAy mouse(BI).

(Sample) age/8
type: EFO_0000001
property type: age
property value: 8

(Sample) organism/Mus musculus
type: Mus musculus
property type: organism
property value: Mus musculus

Lyve1 UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.74822173737415
p value: 0.0328514565435411
refers to: Lyve1
refers to: 1429379_at
t statistic: 5.32560112293017

Socs3 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.56334972139419
p value: 0.00421100654656402
refers to: Socs3
refers to: 1456212_x_at
t statistic: -9.72422098387944

1451190_a_at
type: EFO_0005072
part of: A-AFFY-45

Socs3
type: EnsemblDatabaseReference

Lbp
type: EnsemblDatabaseReference

(Assay) GSM1394569
type: Assay
has participant: A-AFFY-45

Gadd45g DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -2.95321966122967
p value: 0.00170174391681132
refers to: Gadd45g
refers to: 1453851_a_at
t statistic: -12.4359687248002

Gadd45g
type: EnsemblDatabaseReference

(Factor value) COMPOUND/none
type: EFO_0001461
property type: COMPOUND
property value: none

Lyve1
type: EnsemblDatabaseReference

Sema3c UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.00555217049934
p value: 0.0285288320090189
refers to: Sema3c
refers to: 1429348_at
t statistic: 5.69683795958068

1420836_at
type: EFO_0005072
part of: A-AFFY-45

G0s2
type: EnsemblDatabaseReference

(Sample) organism part/liver
type: UBERON_0002107
property type: organism part
property value: liver

(Assay) GSM1394564
type: Assay
has participant: A-AFFY-45

Foxq1
type: EnsemblDatabaseReference

Phlda1
type: EnsemblDatabaseReference

Sbk1
type: EnsemblDatabaseReference

Pnpla3
type: EnsemblDatabaseReference

Orm3 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.07413911409889
p value: 0.0328514565435411
refers to: Orm3
refers to: 1450611_at
t statistic: -5.32905441743831

Dnajc12
type: EnsemblDatabaseReference

1425241_a_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM1394567
type: Assay
has participant: A-AFFY-45

1450018_s_at
type: EFO_0005072
part of: A-AFFY-45

1443619_at
type: EFO_0005072
part of: A-AFFY-45

1438558_x_at
type: EFO_0005072
part of: A-AFFY-45

Elovl6
type: EnsemblDatabaseReference

Wsb1
type: EnsemblDatabaseReference

Mus musculus
type: OBI_0100026

Sbk1
type: EnsemblDatabaseReference

Pnpla3
type: EnsemblDatabaseReference

Foxq1 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.64356593896227
p value: 0.0328514565435411
refers to: Foxq1
refers to: 1422735_at
t statistic: -5.30951979323948

Cish
type: EnsemblDatabaseReference

1417404_at
type: EFO_0005072
part of: A-AFFY-45

Gpm6a
type: EnsemblDatabaseReference

Elovl6
type: EnsemblDatabaseReference

Serpine2 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.15546142274287
p value: 0.0328514565435411
refers to: Serpine2
refers to: 1416666_at
t statistic: -5.31907528426049

Gm6484
type: EnsemblDatabaseReference

Fbln5
type: EnsemblDatabaseReference

Serpine2
type: EnsemblDatabaseReference

Col27a1
type: EnsemblDatabaseReference

A4gnt
type: EnsemblDatabaseReference

1456741_s_at
type: EFO_0005072
part of: A-AFFY-45

Wsb1 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.6073114609869
p value: 0.00357605838435202
refers to: 1425241_a_at
refers to: Wsb1
t statistic: -10.5161677717492

Cish DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -2.42453099321026
p value: 0.0167605240615043
refers to: 1448724_at
refers to: Cish
t statistic: -7.36479795458712

1417403_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM1394566
type: Assay
has participant: A-AFFY-45

1431406_at
type: EFO_0005072
part of: A-AFFY-45

1417441_at
type: EFO_0005072
part of: A-AFFY-45

Slc25a30
type: EnsemblDatabaseReference

Fbln5 UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.03718921588787
p value: 0.0285288320090189
refers to: Fbln5
refers to: 1416164_at
t statistic: 5.53441560161161

Gadd45g
type: EnsemblDatabaseReference

Slc25a30 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.66908616696848
p value: 1.94416424258101E-4
refers to: Slc25a30
refers to: 1450018_s_at
t statistic: -21.595471033331

1458930_at
type: EFO_0005072
part of: A-AFFY-45

Lyve1
type: EnsemblDatabaseReference

G0s2
type: EnsemblDatabaseReference

1447520_at
type: EFO_0005072
part of: A-AFFY-45

Slc25a30 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.4313631401332
p value: 8.7620433800534E-4
refers to: Slc25a30
refers to: 1420835_at
t statistic: -15.988212777441

Gm6484 UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.75669637899508
p value: 0.00444418443948128
refers to: 1427422_at
refers to: Gm6484
t statistic: 9.5130143760605

Elovl6 UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.50094395367918
p value: 0.0478876291624776
refers to: Elovl6
refers to: 1417403_at
t statistic: 4.55513371963209

Phlda1
type: EnsemblDatabaseReference

Elovl6 UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.44296467692774
p value: 0.0276581760759871
refers to: 1417404_at
refers to: Elovl6
t statistic: 5.81154488618312

1416164_at
type: EFO_0005072
part of: A-AFFY-45

Dnajc12 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.45376694680412
p value: 0.0406932185053505
refers to: Dnajc12
refers to: 1417441_at
t statistic: -4.86099403216029

1448724_at
type: EFO_0005072
part of: A-AFFY-45

Sbk1 UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.16703445164238
p value: 0.0478876291624776
refers to: Sbk1
refers to: 1451190_a_at
t statistic: 4.53443094178686

Lbp DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.09800078824106
p value: 0.0328514565435411
refers to: Lbp
refers to: 1447520_at
t statistic: -5.34362416678343

Etnppl
type: EnsemblDatabaseReference

Orm3
type: EnsemblDatabaseReference

Cish
type: EnsemblDatabaseReference

Gpm6a
type: EnsemblDatabaseReference

(Sample) disease/type II diabetes mellitus
type: EFO_0000001
property type: disease
property value: type II diabetes mellitus

1429348_at
type: EFO_0005072
part of: A-AFFY-45

Tmem30a
type: EnsemblDatabaseReference

1427422_at
type: EFO_0005072
part of: A-AFFY-45

Orm3
type: EnsemblDatabaseReference

1456212_x_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM1394570
type: Assay
has participant: A-AFFY-45

Fbln5
type: EnsemblDatabaseReference

Sema3c
type: EnsemblDatabaseReference

A4gnt
type: EnsemblDatabaseReference

Gpm6a UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.50608368467364
p value: 0.0285288320090189
refers to: Gpm6a
refers to: 1456741_s_at
t statistic: 5.6097406329842

Tmem30a DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.15278461014506
p value: 0.0412748037019464
refers to: 1443619_at
refers to: Tmem30a
t statistic: -4.83662048167222

(Assay) GSM1394571
type: Assay
has participant: A-AFFY-45

Sema3c
type: EnsemblDatabaseReference

Slc25a30
type: EnsemblDatabaseReference

1429379_at
type: EFO_0005072
part of: A-AFFY-45

1422735_at
type: EFO_0005072
part of: A-AFFY-45

G0s2 UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 2.11076699007441
p value: 0.00170174391681132
refers to: G0s2
refers to: 1448700_at
t statistic: 12.794759793301

(Assay) GSM1394572
type: Assay
has participant: A-AFFY-45

Pnpla3 UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.16937731084279
p value: 0.0204023071521861
refers to: Pnpla3
refers to: 1420655_at
t statistic: 6.64868740887813

1453851_a_at
type: EFO_0005072
part of: A-AFFY-45

Etnppl UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.83752093251174
p value: 0.0212421117841031
refers to: Etnppl
refers to: 1431406_at
t statistic: 6.5084791286714

Socs3
type: EnsemblDatabaseReference

1418835_at
type: EFO_0005072
part of: A-AFFY-45

1448700_at
type: EFO_0005072
part of: A-AFFY-45

Col27a1 UP in 'biomineralized insulin' vs 'none'
type: IncreasedDifferentialExpressionRatio
fold change: 1.21360901549074
p value: 0.0285288320090189
refers to: Col27a1
refers to: 1429549_at
t statistic: 5.73746548886497

1416666_at
type: EFO_0005072
part of: A-AFFY-45

1455899_x_at
type: EFO_0005072
part of: A-AFFY-45

Socs3 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -1.5203683169013
p value: 0.00398323357184679
refers to: 1455899_x_at
refers to: Socs3
t statistic: -10.1963731176439

(Factor value) COMPOUND/insulin
type: CHEBI 5931
property type: COMPOUND
property value: insulin

A-AFFY-45
type: EFO_0000269

Etnppl
type: EnsemblDatabaseReference

Foxq1 DOWN in 'biomineralized insulin' vs 'none'
type: DecreasedDifferentialExpressionRatio
fold change: -2.82947801584135
p value: 0.00421100654656402
refers to: 1438558_x_at
refers to: Foxq1
t statistic: -9.67636238543855