Ccng1 UP in '6.5 Gray Co60 radiation' vs 'untreated'
To further investigate the potential molecular basis of the protective effects of HSC on irradiation (6.5Gy) damage, gene expression analysis was conducted on rats liver tissues using microarrays.Pre-treatment with HSC prevented differential expression of 66% (1,398 genes) of 2,126 genes differentially expressed in response to radiation. Pathway enrichment analysis indicated that these genes were mainly involved in a total of 32 pathways, such as olfactory transduction, uroactive ligand-receptor interaction, pathways in cancer, calcium signaling pathway, vascular smooth muscle contraction, cytokine-cytokine receptor interaction, mitogen-activated protein kinase (MAPK) signaling pathway, peroxisomal proliferator-activated receptor (PPARÃ¯¼Âsignaling pathway, gonadotropin-releasing hormone (GnRH) signaling pathway, Wnt signaling pathway, janus kinase-signal transducers and activators of transcription (Jak-STAT) signaling pathway, Notch signaling pathway.Our analysis indicated that the pretreatment of rats with HSC attenuated radiation-induced these pathways, such as multiple MAPK pathways, suggesting that the protective effect of HSC acts mainly through the attenuation of these pathways. The rats were randomly assigned to one of the three following treatment groups (10-12 animals per group): normal control, radiation and HSC dose (10g/kg body weight/day) + radiation. HSC dissolved in double distilled water were administered intragastrically to the male animals for 3 consecutive days before irradiation. Radiation induced gene expression in rat liver was measured at 24 hours after 6.5 Gy exposure.
Lsp1 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Rhobtb1 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Cdh17 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Rgs3 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Rsad2 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Stat1 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
RGD1561849 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Hsd17b2 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
(Factor value) COMPOUND/Hong Shan Capsule 6.5
Cryl1 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Spc24 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
MGC108823 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Ifi44 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Orm1 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Slc37a4 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Rnf213 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Nrg1 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Ppp1r15a UP in '6.5 Gray Co60 radiation' vs 'untreated'
Mx2 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Chac1 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Analysis of '6.5 Gray Co60 radiation' vs 'untreated'
Upp2 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Plk1 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Rtp4 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Ankrd46 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Ugp2 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Aen UP in '6.5 Gray Co60 radiation' vs 'untreated'
Usp18 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Phlda3 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Lbp UP in '6.5 Gray Co60 radiation' vs 'untreated'
Tubb4b UP in '6.5 Gray Co60 radiation' vs 'untreated'
Gdf15 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Cdkn1a UP in '6.5 Gray Co60 radiation' vs 'untreated'
Wfdc21 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Acsm3 UP in '6.5 Gray Co60 radiation' vs 'untreated'
(Factor value) IRRADIATE/Cobalt-60 radiation
Spats2l DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
RGD1559960 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Tfrc UP in '6.5 Gray Co60 radiation' vs 'untreated'
Usp2 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Cdk1 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Slc38a2 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Nr4a2 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Adcy9 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Kng1l1 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Pttg1 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Cdkn3 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Nfe2l2 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Ccrn4l UP in '6.5 Gray Co60 radiation' vs 'untreated'
Nr4a1 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Isg15 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Btg2 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Mgmt UP in '6.5 Gray Co60 radiation' vs 'untreated'
Zfp354a DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Rusc2 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
RGD1562658 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Znfx1 DOWN in '6.5 Gray Co60 radiation' vs 'untreated'
Sgk1 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Adh7 UP in '6.5 Gray Co60 radiation' vs 'untreated'
Dbp DOWN in '6.5 Gray Co60 radiation' vs 'untreated'